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Aliases for OR10H5 Gene

Aliases for OR10H5 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 5 2 3 5
  • Olfactory Receptor, Family 10, Subfamily H, Member 5 2 3
  • Olfactory Receptor OR19-25 3 4
  • Olfactory Receptor OR19-26 3 4
  • OR19-25 3
  • OR19-26 3

External Ids for OR10H5 Gene

Previous GeneCards Identifiers for OR10H5 Gene

  • GC19U990263
  • GC19P015766
  • GC19P015904

Summaries for OR10H5 Gene

Entrez Gene Summary for OR10H5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H5 Gene

OR10H5 (Olfactory Receptor Family 10 Subfamily H Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H1.

UniProtKB/Swiss-Prot for OR10H5 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H5 Gene

Genomics for OR10H5 Gene

Regulatory Elements for OR10H5 Gene

Genomic Location for OR10H5 Gene

Chromosome:
19
Start:
15,793,951 bp from pter
End:
15,795,082 bp from pter
Size:
1,132 bases
Orientation:
Plus strand

Genomic View for OR10H5 Gene

Genes around OR10H5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H5 Gene

Proteins for OR10H5 Gene

  • Protein details for OR10H5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA6-O10H5_HUMAN
    Recommended name:
    Olfactory receptor 10H5
    Protein Accession:
    Q8NGA6
    Secondary Accessions:
    • Q6IFJ0
    • Q96R60

    Protein attributes for OR10H5 Gene

    Size:
    315 amino acids
    Molecular mass:
    34900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H5 Gene

Proteomics data for OR10H5 Gene at MOPED

Post-translational modifications for OR10H5 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H5 Gene

Domains & Families for OR10H5 Gene

Gene Families for OR10H5 Gene

Protein Domains for OR10H5 Gene

Suggested Antigen Peptide Sequences for OR10H5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGA6

UniProtKB/Swiss-Prot:

O10H5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H5: view

Function for OR10H5 Gene

Molecular function for OR10H5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR10H5 Gene

GenomeRNAi human phenotypes for OR10H5:
genes like me logo Genes that share phenotypes with OR10H5: view

Animal Model Products

CRISPR Products

miRNA for OR10H5 Gene

miRTarBase miRNAs that target OR10H5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H5 Gene

Localization for OR10H5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10H5 Gene COMPARTMENTS Subcellular localization image for OR10H5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H5: view

Pathways & Interactions for OR10H5 Gene

genes like me logo Genes that share pathways with OR10H5: view

Pathways by source for OR10H5 Gene

Interacting Proteins for OR10H5 Gene

Gene Ontology (GO) - Biological Process for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H5: view

No data available for SIGNOR curated interactions for OR10H5 Gene

Drugs & Compounds for OR10H5 Gene

No Compound Related Data Available

Transcripts for OR10H5 Gene

mRNA/cDNA for OR10H5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H5 Gene

No ASD Table

Relevant External Links for OR10H5 Gene

GeneLoc Exon Structure for
OR10H5
ECgene alternative splicing isoforms for
OR10H5

Expression for OR10H5 Gene

mRNA expression in normal human tissues for OR10H5 Gene

SOURCE GeneReport for Unigene cluster for OR10H5 Gene Hs.553676

genes like me logo Genes that share expression patterns with OR10H5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR10H5 Gene

Orthologs for OR10H5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm4461 35
  • 84.08 (n)
  • 85.03 (a)
Gm4461 16
Gm4461 36
  • 84 (a)
ManyToMany
Olfr239 36
  • 84 (a)
ManyToMany
Olfr55 36
  • 84 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1092 35
  • 83.33 (n)
  • 84.94 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
OR10H1 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 38 (a)
ManyToMany
Species with no ortholog for OR10H5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H5 Gene

ENSEMBL:
Gene Tree for OR10H5 (if available)
TreeFam:
Gene Tree for OR10H5 (if available)

Paralogs for OR10H5 Gene

(452) SIMAP similar genes for OR10H5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H5: view

Variants for OR10H5 Gene

Sequence variations from dbSNP and Humsavar for OR10H5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3746151 -- 15,794,829(-) CTTCA(A/G)GTAAA reference, synonymous-codon
rs4808379 -- 15,794,192(+) GCCAC(C/T)GTCTG reference, synonymous-codon
rs4808380 -- 15,794,396(+) CTCAC(A/C/T)GTCAT reference, synonymous-codon
rs4808381 -- 15,794,621(+) GGAGA(C/T)GATGT reference, synonymous-codon
rs7246118 -- 15,792,863(+) tttgg(C/G)attat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H5 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
esv2718244 CNV Deletion 23290073
nsv833766 CNV Loss 17160897
nsv2425 CNV Insertion 18451855
esv2671181 CNV Deletion 23128226

Variation tolerance for OR10H5 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.04; 96.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H5 Gene

HapMap Linkage Disequilibrium report
OR10H5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H5 Gene

Disorders for OR10H5 Gene

Relevant External Links for OR10H5

Genetic Association Database (GAD)
OR10H5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10H5

No disorders were found for OR10H5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H5 Gene

Publications for OR10H5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR10H5 Gene

Sources for OR10H5 Gene

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