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Aliases for OR10H5 Gene

Aliases for OR10H5 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 5 2 3 5
  • Olfactory Receptor OR19-25 3 4
  • Olfactory Receptor OR19-26 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 5 2
  • Olfactory Receptor 10H5 3
  • OR19-25 3
  • OR19-26 3

External Ids for OR10H5 Gene

Previous GeneCards Identifiers for OR10H5 Gene

  • GC19U990263
  • GC19P015766
  • GC19P015904

Summaries for OR10H5 Gene

Entrez Gene Summary for OR10H5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H5 Gene

OR10H5 (Olfactory Receptor Family 10 Subfamily H Member 5) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H1.

UniProtKB/Swiss-Prot for OR10H5 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H5 Gene

Genomics for OR10H5 Gene

Regulatory Elements for OR10H5 Gene

Enhancers for OR10H5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G015826 2 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +38.8 38814 12.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000269578 AKAP8 CYP4F24P UCA1 OR10H4 OR10H5 ENSG00000268087 CYP4F12 CYP4F11 ENSG00000267904
GH19G016063 1.9 FANTOM5 ENCODE dbSUPER 10.5 +279.0 278963 18.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 MCM3 AKAP8 ENSG00000269578 SMIM7 ENSG00000267904 ENSG00000268087 C19orf44 CYP4F24P ENSG00000268743 SIN3B ENSG00000269427
GH19G015222 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -570.2 -570239 2.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ZNF143 SP3 NOTCH3 RNU6-782P BRD4 OR10H5 WIZ SYDE1 SLC1A6 ENSG00000269635 EPHX3
GH19G015639 1.6 FANTOM5 Ensembl ENCODE 11.3 -152.8 -152810 3.3 FOXA2 ARID4B SIN3A ZNF48 YY1 REST MIER2 ZNF579 SSRP1 MYNN CYP4F12 HSH2D CYP4F10P CYP4F3 OR10H5 RAB8A LINC01835 BRD4 AKAP8 GC19M015646
GH19G015584 1.2 Ensembl ENCODE 10.6 -209.2 -209215 0.7 RB1 ARID4B KLF17 DMAP1 ZNF2 ZNF48 ZSCAN9 ZBTB7B RAD21 ZNF155 AKAP8 CYP4F12 ZNF333 CYP4F11 OR10H5 CYP4F10P CYP4F24P CYP4F3 GC19P015580 GC19P015593
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10H5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10H5 Gene

Chromosome:
19
Start:
15,793,951 bp from pter
End:
15,795,082 bp from pter
Size:
1,132 bases
Orientation:
Plus strand

Genomic View for OR10H5 Gene

Genes around OR10H5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H5 Gene

Proteins for OR10H5 Gene

  • Protein details for OR10H5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA6-O10H5_HUMAN
    Recommended name:
    Olfactory receptor 10H5
    Protein Accession:
    Q8NGA6
    Secondary Accessions:
    • Q6IFJ0
    • Q96R60

    Protein attributes for OR10H5 Gene

    Size:
    315 amino acids
    Molecular mass:
    34900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H5 Gene

Post-translational modifications for OR10H5 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H5 Gene

Domains & Families for OR10H5 Gene

Gene Families for OR10H5 Gene

Protein Domains for OR10H5 Gene

Suggested Antigen Peptide Sequences for OR10H5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGA6

UniProtKB/Swiss-Prot:

O10H5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H5: view

Function for OR10H5 Gene

Molecular function for OR10H5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H5: view

Phenotypes for OR10H5 Gene

GenomeRNAi human phenotypes for OR10H5:
genes like me logo Genes that share phenotypes with OR10H5: view

Animal Model Products

CRISPR Products

miRNA for OR10H5 Gene

miRTarBase miRNAs that target OR10H5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H5 Gene

Localization for OR10H5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H5: view

Pathways & Interactions for OR10H5 Gene

genes like me logo Genes that share pathways with OR10H5: view

Pathways by source for OR10H5 Gene

Interacting Proteins for OR10H5 Gene

Gene Ontology (GO) - Biological Process for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H5: view

No data available for SIGNOR curated interactions for OR10H5 Gene

Drugs & Compounds for OR10H5 Gene

No Compound Related Data Available

Transcripts for OR10H5 Gene

mRNA/cDNA for OR10H5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H5 Gene

No ASD Table

Relevant External Links for OR10H5 Gene

GeneLoc Exon Structure for
OR10H5
ECgene alternative splicing isoforms for
OR10H5

Expression for OR10H5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H5 Gene:

OR10H5

SOURCE GeneReport for Unigene cluster for OR10H5 Gene:

Hs.553676
genes like me logo Genes that share expression patterns with OR10H5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H5 Gene

Orthologs for OR10H5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10H1 35
  • 86 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm4461 34 35
  • 84.08 (n)
Olfr239 35
  • 84 (a)
ManyToMany
Olfr55 35
  • 84 (a)
ManyToMany
Olfr1564 16
rat
(Rattus norvegicus)
Mammalia Olr1092 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 38 (a)
ManyToMany
Species where no ortholog for OR10H5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H5 Gene

ENSEMBL:
Gene Tree for OR10H5 (if available)
TreeFam:
Gene Tree for OR10H5 (if available)

Paralogs for OR10H5 Gene

(452) SIMAP similar genes for OR10H5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H5: view

Variants for OR10H5 Gene

Sequence variations from dbSNP and Humsavar for OR10H5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000625131 -- 15,794,126(+) CTGAT(C/G)CTCTT reference, missense
rs1000690213 -- 15,793,110(+) CACAG(-/TTTGTT)TTTGT upstream-variant-2KB
rs1001352764 -- 15,793,878(+) CATCT(-/CAAAAA)CTAAA upstream-variant-2KB
rs1003023898 -- 15,793,003(+) AGGAA(G/T)AATAA upstream-variant-2KB
rs1004206669 -- 15,792,426(+) ACTTT(A/T)GTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H5 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1060711 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv2425 CNV insertion 18451855
nsv833766 CNV loss 17160897

Variation tolerance for OR10H5 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.04; 96.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H5 Gene

Disorders for OR10H5 Gene

Relevant External Links for OR10H5

Genetic Association Database (GAD)
OR10H5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10H5

No disorders were found for OR10H5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H5 Gene

Publications for OR10H5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR10H5 Gene

Sources for OR10H5 Gene

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