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OR10H4 Gene

protein-coding   GIFtS: 46
GCID: GC19P016059

Olfactory Receptor, Family 10, Subfamily H, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily H, Member 41 2
Olfactory Receptor OR19-282 3
OR19-282
Olfactory Receptor 10H42

External Ids:    HGNC: 153881   Entrez Gene: 1265412   Ensembl: ENSG000001762317   UniProtKB: Q8NGA53   

Export aliases for OR10H4 gene to outside databases

Previous GC identifers: GC19U990264 GC19P015921 GC19P015922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10H4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10H4 Gene:
OR10H4 (olfactory receptor, family 10, subfamily H, member 4) is a protein-coding gene. GO annotations related to this gene include serotonin receptor activity and olfactory receptor activity. An important paralog of this gene is OR10K2.

UniProtKB/Swiss-Prot: O10H4_HUMAN, Q8NGA5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10H4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10H4 gene promoter:
         Tal-1   SREBP-1c   Tal-1beta   E47   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   ITF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10H4 promoter sequence
   Search Chromatin IP Primers for OR10H4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10H4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

OR10H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10H4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016059:  view genomic region     (about GC identifiers)

Start:
16,059,818 bp from pter      End:
16,060,765 bp from pter
Size:
948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O10H4_HUMAN, Q8NGA5 (See protein sequence)
Recommended Name: Olfactory receptor 10H4  
Size: 316 amino acids; 35765 Da
Secondary accessions: Q6IFJ2 Q96R57

Explore the universe of human proteins at neXtProt for OR10H4: NX_Q8NGA5

Explore proteomics data for OR10H4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR10H4

    See OR10H4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004465.1  
    ENSEMBL proteins: 
     ENSP00000318834  
    Reactome Protein details: Q8NGA5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGA5

    ProtoNet protein and cluster: Q8NGA5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10H4_HUMAN, Q8NGA5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10H4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10H4_HUMAN, Q8NGA5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR10H4           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10H4_HUMAN, Q8NGA5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR10H4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10H4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR10H4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR10H4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10H4):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10H4
    Interactions:

        Search GeneGlobe Interaction Network for OR10H4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10H4 (ENSP000003188344) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR2V1ENSP000004041024STRING: ENSP00000404102
    OR2V2ENSP000003321854STRING: ENSP00000332185
    OR51I1ENSP000003695594STRING: ENSP00000369559
    OR6A2ENSP000003303844STRING: ENSP00000330384
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with OR10H4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10H4 (O10H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10H4 gene: 
    NM_001004465.1  

    Unigene Cluster for OR10H4:

    Olfactory receptor, family 10, subfamily H, member 4
    Hs.553579
    Unigene Representative Sequence: NM_001004465
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322107(uc010xov.2)
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    1 AceView cDNA sequence:

    NM_001004465 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10H4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTCCCT
    OR10H4 Expression
    About this image

    OR10H4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10H4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553579
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR10H4 (if available)
    TreeFam Gene Tree for OR10H4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10H4 gene
    OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  OR10H12  
    OR10J32  OR10H22  OR10R22  OR10H32  OR10K12  OR10J12  
    Selected SIMAP similar genes for OR10H4 using alignment to 1 protein entry:     O10H4_HUMAN(see all similar genes):
    OR10H3    OR10H2    OR10H1    OR10H5    OR10X1    OR10J4
    OR10J5    OR10K1    OR10R3P    OR10J1    OR10J3    OR10K2
    OR10R2    OR2K2    OR10T2    OR13D1    OR13G1    OR10Z1

    Find genes that share paralogs with OR10H4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10H4 (see all 125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486119351,2
    Cuntested116060623(+) CCATTA/C/TTATGT 2 S F mis11NA 4550
    rs1814466381,2
    --16057988(+) TTTTTA/TATATC 1 -- us2k10--------
    rs116664201,2
    C,F,H--16058163(+) CTTTCT/GAACTA 1 -- us2k112Minor allele frequency- G:0.28NA WA CSA EA 508
    rs735082121,2
    C,F--16058203(+) TATTCC/TAGGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs169809831,2
    C,F--16058289(+) ATGGTA/GTGAAT 1 -- us2k111Minor allele frequency- G:0.27NA WA CSA EA 508
    rs105002111,2
    C,F,H--16058348(+) TCAAGA/TAACAA 1 -- us2k124Minor allele frequency- T:0.15NS NA EA CSA WA 2453
    rs176414831,2
    C,F,H--16058371(+) CAGCCG/AAAATA 1 -- us2k118Minor allele frequency- A:0.03NA NS EA 2230
    rs1418709881,2
    --16058456(+) TGACAC/TAGGAA 1 -- us2k10--------
    rs1506411671,2
    --16058501(+) GGCAAA/GAATGT 1 -- us2k10--------
    rs802191041,2
    C,F--16058530(+) AAAAAA/TTTTTT 1 -- us2k11Minor allele frequency- T:0.08WA 118

    HapMap Linkage Disequilibrium report for OR10H4 ( 16059818 - 16060765 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR10H4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718244CNV Deletion23290073
    nsv833766CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10H4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10H4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126541 HGNC: 15388 AceView: OR10H4 Ensembl:ENSG00000176231 euGenes: HUgn126541
    ECgene: OR10H4 Kegg: 126541 H-InvDB: OR10H4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10H4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10H4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10H4 gene:
    Search GeneIP for patents involving OR10H4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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