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Aliases for OR10H4 Gene

Aliases for OR10H4 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 4 2 3 5
  • Olfactory Receptor OR19-28 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 4 2
  • Olfactory Receptor 10H4 3
  • OR19-28 3

External Ids for OR10H4 Gene

Previous GeneCards Identifiers for OR10H4 Gene

  • GC19U990264
  • GC19P015921
  • GC19P015922
  • GC19P016059

Summaries for OR10H4 Gene

Entrez Gene Summary for OR10H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H4 Gene

OR10H4 (Olfactory Receptor Family 10 Subfamily H Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H3.

UniProtKB/Swiss-Prot for OR10H4 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H4 Gene

Additional gene information for OR10H4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H4 Gene

Genomics for OR10H4 Gene

Regulatory Elements for OR10H4 Gene

Enhancers for OR10H4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H015826 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -111.5 -111535 12.9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000269578 AKAP8 SIN3B CHERP MED26 C19orf44 BRD4 CYP4F24P UCA1 OR10H4
GH19H016040 1.1 Ensembl ENCODE 10.5 +96.9 96932 1.5 ELF3 TBP RB1 ARID4B BRCA1 RAD21 ZNF121 ZNF143 ZNF654 CEBPB CIB3 FAM32A SNX33P1 AP1M1 OR10H4 OR10H5 LINC00905 PIR51994 OR1AB1P
GH19H016001 0.9 Ensembl ENCODE 10.9 +58.1 58053 1.9 HLF CEBPB MAX CEBPG BATF RAD21 NR2F2 ZNF7 RELA POLR2A LINC00661 CYP4F11 OR10H4 CYP4F9P PIR55720
GH19H015824 0.8 dbSUPER 10.8 -119.3 -119343 1.7 ETV1 BACH1 ZNF175 PYGO2 ZNF644 ZNF507 RELA IRF9 ZNF766 NFE2 C19orf44 CHERP AKAP8 CYP4F24P ENSG00000267904 ENSG00000269578 OR10H5 ENSG00000268087 CYP4F11 OR10H4
GH19H016168 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +224.7 224662 1.6 BCOR ZMYM3 MAX POLR2A NFYB ADNP SMARCC2 SMARCA5 NFYA USF2 OR10H3 OR10H2 AP1M1 OR10H4 CIB3 ENSG00000269243
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10H4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR10H4 Gene

Genomic Locations for OR10H4 Gene
6,052 bases
Plus strand

Genomic View for OR10H4 Gene

Genes around OR10H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H4 Gene

Proteins for OR10H4 Gene

  • Protein details for OR10H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10H4
    Protein Accession:
    Secondary Accessions:
    • Q6IFJ2
    • Q96R57

    Protein attributes for OR10H4 Gene

    316 amino acids
    Molecular mass:
    35765 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H4 Gene

Post-translational modifications for OR10H4 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H4 Gene

Domains & Families for OR10H4 Gene

Gene Families for OR10H4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H4 Gene

Suggested Antigen Peptide Sequences for OR10H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H4: view

Function for OR10H4 Gene

Molecular function for OR10H4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10H4 Gene

Gene Ontology (GO) - Molecular Function for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H4: view

Phenotypes for OR10H4 Gene

genes like me logo Genes that share phenotypes with OR10H4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H4 Gene

Localization for OR10H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H4 Gene

Pathways & Interactions for OR10H4 Gene

genes like me logo Genes that share pathways with OR10H4: view

Pathways by source for OR10H4 Gene

Interacting Proteins for OR10H4 Gene

Gene Ontology (GO) - Biological Process for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR10H4: view

No data available for SIGNOR curated interactions for OR10H4 Gene

Drugs & Compounds for OR10H4 Gene

No Compound Related Data Available

Transcripts for OR10H4 Gene

mRNA/cDNA for OR10H4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H4 Gene

No ASD Table

Relevant External Links for OR10H4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H4 Gene:


SOURCE GeneReport for Unigene cluster for OR10H4 Gene:

genes like me logo Genes that share expression patterns with OR10H4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H4 Gene

Orthologs for OR10H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468757 33
  • 98.63 (n)
OR10H4 34
  • 97 (a)
(Bos Taurus)
Mammalia LOC506323 33
  • 85.45 (n)
-- 34
  • 82 (a)
-- 34
  • 81 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
(Mus musculus)
Mammalia Olfr63 34
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
-- 34
  • 67 (a)
-- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
Species where no ortholog for OR10H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H4 Gene

Gene Tree for OR10H4 (if available)
Gene Tree for OR10H4 (if available)

Paralogs for OR10H4 Gene

(446) SIMAP similar genes for OR10H4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H4: view

Variants for OR10H4 Gene

Sequence variations from dbSNP and Humsavar for OR10H4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000277481 -- 15,949,097(+) TTCCT(G/T)CTGTA reference, synonymous-codon
rs1000496488 -- 15,949,991(+) ATAAT(C/G)TGTAT downstream-variant-500B
rs1000538554 -- 15,947,069(+) TATAG(G/T)TAGCT upstream-variant-2KB
rs1000565641 -- 15,948,882(+) GTGAG(A/G)CCCAG upstream-variant-2KB
rs1001015465 -- 15,950,206(+) TCTGG(A/G)CACTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR10H4 Gene

Variant ID Type Subtype PubMed ID
nsv960803 CNV duplication 23825009
nsv833766 CNV loss 17160897
nsv1064684 CNV gain 25217958
esv2718244 CNV deletion 23290073

Variation tolerance for OR10H4 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H4 Gene

Disorders for OR10H4 Gene

Relevant External Links for OR10H4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR10H4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H4 Gene

Publications for OR10H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60

Products for OR10H4 Gene

Sources for OR10H4 Gene

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