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Aliases for OR10H3 Gene

Aliases for OR10H3 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 3 2 3 5
  • Olfactory Receptor, Family 10, Subfamily H, Member 3 2
  • Olfactory Receptor OR19-24 4

External Ids for OR10H3 Gene

Previous GeneCards Identifiers for OR10H3 Gene

  • GC19M016317
  • GC19P016245
  • GC19P015697
  • GC19P015713
  • GC19P015852

Summaries for OR10H3 Gene

Entrez Gene Summary for OR10H3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H3 Gene

OR10H3 (Olfactory Receptor Family 10 Subfamily H Member 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot for OR10H3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H3 Gene

Genomics for OR10H3 Gene

Regulatory Elements for OR10H3 Gene

Enhancers for OR10H3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G015826 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +91.4 91372 12.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000269578 AKAP8 CYP4F24P UCA1 OR10H4 OR10H5 ENSG00000268087 CYP4F12 CYP4F11 ENSG00000267904
GH19G016168 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +427.6 427568 1.6 FOXA2 SIN3A FOS DEK NFYC TSHZ1 MAFF GLIS1 KDM1A WT1 SIN3B ENSG00000268743 OR10H3 ENSG00000269044 OR10H2 AP1M1 OR10H4 CIB3 ENSG00000269243
GH19G016063 1.9 FANTOM5 ENCODE dbSUPER 2.3 +331.5 331521 18.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 MCM3 AKAP8 ENSG00000269578 SMIM7 ENSG00000267904 ENSG00000268087 C19orf44 CYP4F24P ENSG00000268743 SIN3B ENSG00000269427
GH19G015820 0.3 FANTOM5 7.7 +79.6 79572 0.1 OR10H4 OR10H5 CYP4F11 OR10H3 OR10H2 AKAP8 RASAL3 ZNF861P OR10H1
GH19G015865 0.3 FANTOM5 1.9 +123.1 123062 0.1 OR10H3 OR10H2 LINC01835 LOC105369202
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10H3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10H3 Gene

Chromosome:
19
Start:
15,741,393 bp from pter
End:
15,742,343 bp from pter
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10H3 Gene

Genes around OR10H3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H3 Gene

Proteins for OR10H3 Gene

  • Protein details for OR10H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60404-O10H3_HUMAN
    Recommended name:
    Olfactory receptor 10H3
    Protein Accession:
    O60404
    Secondary Accessions:
    • Q2HIZ3
    • Q6IFQ0

    Protein attributes for OR10H3 Gene

    Size:
    316 amino acids
    Molecular mass:
    35721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H3 Gene

Post-translational modifications for OR10H3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10H3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H3 Gene

Domains & Families for OR10H3 Gene

Gene Families for OR10H3 Gene

Protein Domains for OR10H3 Gene

Suggested Antigen Peptide Sequences for OR10H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60404

UniProtKB/Swiss-Prot:

O10H3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H3: view

Function for OR10H3 Gene

Molecular function for OR10H3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H3: view
genes like me logo Genes that share phenotypes with OR10H3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H3 Gene

Localization for OR10H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H3: view

Pathways & Interactions for OR10H3 Gene

genes like me logo Genes that share pathways with OR10H3: view

Pathways by source for OR10H3 Gene

1 BioSystems pathway for OR10H3 Gene
1 KEGG pathway for OR10H3 Gene

Gene Ontology (GO) - Biological Process for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H3: view

No data available for SIGNOR curated interactions for OR10H3 Gene

Drugs & Compounds for OR10H3 Gene

No Compound Related Data Available

Transcripts for OR10H3 Gene

mRNA/cDNA for OR10H3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H3 Gene

No ASD Table

Relevant External Links for OR10H3 Gene

GeneLoc Exon Structure for
OR10H3
ECgene alternative splicing isoforms for
OR10H3

Expression for OR10H3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H3 Gene:

OR10H3

SOURCE GeneReport for Unigene cluster for OR10H3 Gene:

Hs.553524
genes like me logo Genes that share expression patterns with OR10H3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H3 Gene

Orthologs for OR10H3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468756 34
  • 98.42 (n)
OR10H3 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR10H10 34
  • 84.5 (n)
-- 35
  • 41 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 81 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
-- 35
  • 78 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100909683 34
  • 80.85 (n)
mouse
(Mus musculus)
Mammalia Or10h28 55 Olfr63 34 16 35
  • 79.89 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToMany
Species where no ortholog for OR10H3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H3 Gene

ENSEMBL:
Gene Tree for OR10H3 (if available)
TreeFam:
Gene Tree for OR10H3 (if available)

Paralogs for OR10H3 Gene

(439) SIMAP similar genes for OR10H3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H3: view

Variants for OR10H3 Gene

Sequence variations from dbSNP and Humsavar for OR10H3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000236121 -- 15,741,976(+) GACAT(C/G)ATCTG reference, stop-gained
rs1001514495 -- 15,742,575(+) TCTGT(A/G)GATAG downstream-variant-500B
rs1002622740 -- 15,739,686(+) ACTCC(A/G)TCTCA upstream-variant-2KB
rs1002965783 -- 15,740,864(+) TTTTT(C/G)AATTT upstream-variant-2KB
rs1004489279 -- 15,741,198(+) GTTTG(A/C)TCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H3 Gene

Variant ID Type Subtype PubMed ID
dgv3454n100 CNV gain 25217958
esv3260 OTHER inversion 18987735
esv3334671 CNV duplication 20981092
nsv1059468 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1079032 OTHER inversion 25765185
nsv1133007 OTHER inversion 24896259
nsv1141884 OTHER inversion 24896259
nsv1153107 OTHER inversion 26484159
nsv526168 CNV gain 19592680

Variation tolerance for OR10H3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.06; 96.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H3 Gene

Disorders for OR10H3 Gene

Relevant External Links for OR10H3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10H3

No disorders were found for OR10H3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H3 Gene

Publications for OR10H3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64

Products for OR10H3 Gene

Sources for OR10H3 Gene

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