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Aliases for OR10H3 Gene

Aliases for OR10H3 Gene

  • Olfactory Receptor, Family 10, Subfamily H, Member 3 2 3
  • Olfactory Receptor OR19-24 4

External Ids for OR10H3 Gene

Summaries for OR10H3 Gene

Entrez Gene Summary for OR10H3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H3 Gene

OR10H3 (Olfactory Receptor, Family 10, Subfamily H, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include olfactory receptor activity and serotonin receptor activity. An important paralog of this gene is OR10X1.

UniProtKB/Swiss-Prot for OR10H3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H3 Gene

Genomics for OR10H3 Gene

Genomic Location for OR10H3 Gene

Start:
15,741,393 bp from pter
End:
15,742,343 bp from pter
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10H3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H3 Gene

Regulatory Elements for OR10H3 Gene

Proteins for OR10H3 Gene

  • Protein details for OR10H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60404-O10H3_HUMAN
    Recommended name:
    Olfactory receptor 10H3
    Protein Accession:
    O60404
    Secondary Accessions:
    • Q2HIZ3
    • Q6IFQ0

    Protein attributes for OR10H3 Gene

    Size:
    316 amino acids
    Molecular mass:
    35721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H3 Gene

Proteomics data for OR10H3 Gene at MOPED

Post-translational modifications for OR10H3 Gene

No Post-translational modifications

Other Protein References for OR10H3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10H3 Gene

Domains for OR10H3 Gene

Gene Families for OR10H3 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10H3 Gene

Suggested Antigen Peptide Sequences for OR10H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60404

UniProtKB/Swiss-Prot:

O10H3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O60404
genes like me logo Genes that share domains with OR10H3: view

Function for OR10H3 Gene

Molecular function for OR10H3 Gene

GENATLAS Biochemistry: olfactory receptor,family 10,subfamily H,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10H3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10H3 Gene

Localization for OR10H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10H3 Gene COMPARTMENTS Subcellular localization image for OR10H3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H3: view

Pathways for OR10H3 Gene

genes like me logo Genes that share pathways with OR10H3: view

Pathways by source for OR10H3 Gene

1 BioSystems pathway for OR10H3 Gene
1 KEGG pathway for OR10H3 Gene

Interacting Proteins for OR10H3 Gene

Gene Ontology (GO) - Biological Process for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H3: view

Transcripts for OR10H3 Gene

mRNA/cDNA for OR10H3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H3 Gene

No ASD Table

Relevant External Links for OR10H3 Gene

GeneLoc Exon Structure for
OR10H3
ECgene alternative splicing isoforms for
OR10H3

Expression for OR10H3 Gene

mRNA expression in normal human tissues for OR10H3 Gene

SOURCE GeneReport for Unigene cluster for OR10H3 Gene Hs.553524

genes like me logo Genes that share expressions with OR10H3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR10H3 Gene

Orthologs for OR10H3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468756 35
  • 98.42 (n)
  • 95.57 (a)
OR10H3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
ManyToMany
cOR10H10 35
  • 84.5 (n)
  • 82.17 (a)
mouse
(Mus musculus)
Mammalia Olfr63 35
  • 79.89 (n)
  • 76.83 (a)
Olfr63 16
Olfr63 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100909683 35
  • 80.85 (n)
  • 78.1 (a)
Species with no ortholog for OR10H3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H3 Gene

ENSEMBL:
Gene Tree for OR10H3 (if available)
TreeFam:
Gene Tree for OR10H3 (if available)

Paralogs for OR10H3 Gene

Selected SIMAP similar genes for OR10H3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H3: view

Variants for OR10H3 Gene

Sequence variations from dbSNP and Humsavar for OR10H3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1966357 - 15,741,413(+) TACAG(A/C)ACCAT reference, missense
rs2240227 - 15,741,432(+) TTATC(A/C)TCTCT missense, reference
rs2240228 - 15,742,062(+) TCATT(A/G)TGGCT missense, reference
rs2240229 - 15,742,270(+) TTTCA(A/G)TCTAA missense, reference
rs4808373 -- 15,741,162(+) CCAAC(A/C)TCTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H3 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
nsv526168 CNV Gain 19592680
esv3260 OTHER Inversion 18987735

Relevant External Links for OR10H3 Gene

HapMap Linkage Disequilibrium report
OR10H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H3 Gene

Disorders for OR10H3 Gene

No disorders were found for OR10H3 Gene.

No data available for UniProtKB/Swiss-Prot for OR10H3 Gene

Publications for OR10H3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR10H3 Gene

Sources for OR10H3 Gene

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