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OR10H3 Gene

protein-coding   GIFtS: 50
GCID: GC19P015852

Olfactory Receptor, Family 10, Subfamily H, Member 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily H, Member 31 2
Olfactory Receptor OR19-242 3
Olfactory Receptor 10H32

External Ids:    HGNC: 81741   Entrez Gene: 265322   Ensembl: ENSG000001719367   UniProtKB: O604043   

Export aliases for OR10H3 gene to outside databases

Previous GC identifers: GC19M016317 GC19P016245 GC19P015697 GC19P015713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10H3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10H3 Gene:
OR10H3 (olfactory receptor, family 10, subfamily H, member 3) is a protein-coding gene. Diseases associated with OR10H3 include neuronitis. GO annotations related to this gene include serotonin receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10H3_HUMAN, O60404
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10H3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10H3 gene promoter:
         Max1   AhR   RFX1   RP58   Tal-1beta   E47   CREB   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10H3 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10H3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR10H3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10H3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015852:  view genomic region     (about GC identifiers)

Start:
15,852,203 bp from pter      End:
15,853,150 bp from pter
Size:
948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: O10H3_HUMAN, O60404 (See protein sequence)
Recommended Name: Olfactory receptor 10H3  
Size: 316 amino acids; 35721 Da
Secondary accessions: Q2HIZ3 Q6IFQ0

Explore the universe of human proteins at neXtProt for OR10H3: NX_O60404

HORDE protein sequence for OR10H3

REFSEQ proteins: NP_039226.1  
ENSEMBL proteins: 
 ENSP00000307130  
Reactome Protein details: O60404

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR10: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry O60404

ProtoNet protein and cluster: O60404

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10H3_HUMAN, O60404
Similarity: Belongs to the G-protein coupled receptor 1 family


OR10H3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O10H3_HUMAN, O60404
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR10H3:
olfactory receptor,family 10,subfamily H,member 3,G protein coupled receptor superfamily

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR10H3 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O10H3_HUMAN, O60404: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR10H3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR10H3 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Peptide ligand-binding receptors
GPCRs, Class A Rhodopsin-like0.43

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR10H3
    GPCRs, Class A Rhodopsin-like


1 Reactome Pathway for OR10H3
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR10H3):
    Olfactory transduction


OR10H3 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10H3
Interactions:

    Search GeneGlobe Interaction Network for OR10H3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR10H3 (ENSP000003071304) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR1D2ENSP000003275854STRING: ENSP00000327585
OR2V1ENSP000004041024STRING: ENSP00000404102
OR2V2ENSP000003321854STRING: ENSP00000332185
OR4Q3ENSP000003300494STRING: ENSP00000330049
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR10H3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR10H3 (O10H3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR10H3 gene: 
NM_013938.1  

Unigene Cluster for OR10H3:

Olfactory receptor, family 10, subfamily H, member 3
Hs.553524
Unigene Representative Sequence: NM_013938
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000305892(uc010xoq.2)
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Additional mRNA sequence: 

BC106707.2 BC113844.1 

1 DOTS entry:

DT.91893802 

1 AceView cDNA sequence:

NM_013938 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR10H3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CACTATAGTT
OR10H3 Expression
About this image

OR10H3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.553524
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR10H3 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr631 , 5 olfactory receptor 631, 5 79.89(n)1
76.83(a)1
  17 (17.98 cM)5
2589391  NM_146937.11  NP_667148.11 
 332687265 


ENSEMBL Gene Tree for OR10H3 (if available)
TreeFam Gene Tree for OR10H3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR10H3 gene
OR10H42  OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  
OR10H12  OR10J32  OR10H22  OR10R22  OR10K12  OR10J12  
Selected SIMAP similar genes for OR10H3 using alignment to 1 protein entry:     O10H3_HUMAN(see all similar genes):
OR10H4    OR10H2    OR10H1    OR10H5    OR10X1    OR10J4
OR10J5    OR10K1    OR10R3P    OR2K2    OR10K2    OR10J1
OR10J3    OR10R2    OR10Z1    OR13D1    OR13F1    OR10T2

OR10H3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR10H3 (see all 115)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs283795461,2
C,F--15850293(+) GTCAGG/AAGTTT 1 -- us2k13Minor allele frequency- A:0.33NA WA 6
rs1384757201,2
--15850365(+) GCGTGA/GTGGCA 1 -- us2k10--------
rs1414293221,2
C--15850373(+) GCACGC/TGCCTG 1 -- us2k10--------
rs1859885451,2
C--15850388(+) CCCAGA/CTATTA 1 -- us2k10--------
rs1449456611,2
--15850433(+) GAAGGA/GGAGGT 1 -- us2k10--------
rs1388209391,2
--15850515(+) ATAATA/CAATCT 1 -- us2k10--------
rs1906563491,2
--15850566(+) TATTGA/TTTATT 1 -- us2k10--------
rs1414528091,2
--15850567(+) ATTGAC/TTATTT 1 -- us2k10--------
rs1825371871,2
--15850622(+) TTGATA/GCTGTT 1 -- us2k10--------
rs784194921,2
C,F--15850632(+) TTGCTA/GTGTTC 1 -- us2k11Minor allele frequency- G:0.05NA 120

HapMap Linkage Disequilibrium report for OR10H3 ( 15852203 - 15853150 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR10H3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv911139CNV Gain21882294
nsv526168CNV Gain19592680
esv3260OTHER Inversion18987735

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR10H3:    
About MalaCards
neuronitis


OR10H3 for disorders           About GeneDecksing


Export disorders for OR10H3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR10H3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR10H3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26532 HGNC: 8174 AceView: OR10H3 Ensembl:ENSG00000171936 euGenes: HUgn26532
ECgene: OR10H3 Kegg: 26532 H-InvDB: OR10H3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR10H3 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR10H3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR10H3 gene:
Search GeneIP for patents involving OR10H3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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