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Aliases for OR10H3 Gene

Aliases for OR10H3 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 3 2 3 5
  • Olfactory Receptor, Family 10, Subfamily H, Member 3 2
  • Olfactory Receptor OR19-24 4

External Ids for OR10H3 Gene

Previous GeneCards Identifiers for OR10H3 Gene

  • GC19M016317
  • GC19P016245
  • GC19P015697
  • GC19P015713
  • GC19P015852

Summaries for OR10H3 Gene

Entrez Gene Summary for OR10H3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H3 Gene

OR10H3 (Olfactory Receptor Family 10 Subfamily H Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot for OR10H3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H3 Gene

Genomics for OR10H3 Gene

Regulatory Elements for OR10H3 Gene

Enhancers for OR10H3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F016168 0.8 FANTOM5 Ensembl ENCODE 10.1 +427.6 427568 1.6 SIN3A FOS DEK NFYC TSHZ1 MAFF GLIS1 KDM1A WT1 SP7 SIN3B ENSG00000268743 OR10H3 ENSG00000269044 OR10H2 AP1M1 OR10H4 CIB3 ENSG00000269243
GH19F015826 1 FANTOM5 ENCODE 9.4 +91.4 91372 12.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000269578 AKAP8 ENSG00000268087 CYP4F24P UCA1 OR10H4 ENSG00000269044 OR10H5 CYP4F12 CYP4F11
GH19F015820 0.6 FANTOM5 7.7 +79.6 79572 0.1 OR10H4 OR10H5 CYP4F11 OR10H3 OR10H2 AKAP8 RASAL3 ZNF861P OR10H1
GH19F016063 1 FANTOM5 ENCODE 2.3 +331.5 331521 18.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 MCM3 SP3 ENSG00000269578 ENSG00000268087 AKAP8 C19orf44 ENSG00000267904 SIN3B OR10H5 ENSG00000268743 LINC01855 ENSG00000269044
GH19F015864 0.7 FANTOM5 1.9 +123.1 123062 0.1 OR10H3 OR10H2 LINC01835 LOC105369202
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR10H3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10H3 Gene

15,741,393 bp from pter
15,742,343 bp from pter
951 bases
Plus strand

Genomic View for OR10H3 Gene

Genes around OR10H3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H3 Gene

Proteins for OR10H3 Gene

  • Protein details for OR10H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10H3
    Protein Accession:
    Secondary Accessions:
    • Q2HIZ3
    • Q6IFQ0

    Protein attributes for OR10H3 Gene

    316 amino acids
    Molecular mass:
    35721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H3 Gene

Post-translational modifications for OR10H3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10H3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H3 Gene

Domains & Families for OR10H3 Gene

Gene Families for OR10H3 Gene

Protein Domains for OR10H3 Gene

Suggested Antigen Peptide Sequences for OR10H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H3: view

Function for OR10H3 Gene

Molecular function for OR10H3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H3: view
genes like me logo Genes that share phenotypes with OR10H3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H3 Gene

Localization for OR10H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR10H3 Gene COMPARTMENTS Subcellular localization image for OR10H3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with OR10H3: view

Pathways & Interactions for OR10H3 Gene

genes like me logo Genes that share pathways with OR10H3: view

Pathways by source for OR10H3 Gene

1 BioSystems pathway for OR10H3 Gene
1 KEGG pathway for OR10H3 Gene

Interacting Proteins for OR10H3 Gene

Gene Ontology (GO) - Biological Process for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H3: view

No data available for SIGNOR curated interactions for OR10H3 Gene

Transcripts for OR10H3 Gene

mRNA/cDNA for OR10H3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H3 Gene

No ASD Table

Relevant External Links for OR10H3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10H3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10H3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H3 Gene:


SOURCE GeneReport for Unigene cluster for OR10H3 Gene:

genes like me logo Genes that share expression patterns with OR10H3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR10H3 Gene

Orthologs for OR10H3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468756 34
  • 98.42 (n)
OR10H3 35
  • 96 (a)
(Canis familiaris)
Mammalia cOR10H10 34
  • 84.5 (n)
-- 35
  • 41 (a)
(Bos Taurus)
Mammalia -- 35
  • 81 (a)
-- 35
  • 80 (a)
-- 35
  • 79 (a)
-- 35
  • 79 (a)
-- 35
  • 78 (a)
-- 35
  • 71 (a)
-- 35
  • 68 (a)
(Rattus norvegicus)
Mammalia LOC100909683 34
  • 80.85 (n)
(Mus musculus)
Mammalia Or10h28 55 Olfr63 34 16 35
  • 79.89 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
-- 35
  • 66 (a)
-- 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
Species where no ortholog for OR10H3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H3 Gene

Gene Tree for OR10H3 (if available)
Gene Tree for OR10H3 (if available)

Paralogs for OR10H3 Gene

(439) SIMAP similar genes for OR10H3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H3: view

Variants for OR10H3 Gene

Sequence variations from dbSNP and Humsavar for OR10H3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10518249 -- 15,740,333(+) CTGTA(A/G)TCAAA upstream-variant-2KB
rs10518250 -- 15,740,419(+) AGTTA(C/T)TATGT upstream-variant-2KB
rs10518251 -- 15,740,451(+) TCAAT(A/G)TACCT upstream-variant-2KB
rs113450964 -- 15,740,091(+) TCTAC(-/A)AAAAA upstream-variant-2KB
rs11375276 -- 15,740,092(+) CTACA(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H3 Gene

Variant ID Type Subtype PubMed ID
dgv3454n100 CNV gain 25217958
esv3260 OTHER inversion 18987735
esv3334671 CNV duplication 20981092
nsv1059468 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1079032 OTHER inversion 25765185
nsv1133007 OTHER inversion 24896259
nsv1141884 OTHER inversion 24896259
nsv1153107 OTHER inversion 26484159
nsv526168 CNV gain 19592680

Variation tolerance for OR10H3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.06; 96.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H3 Gene

Disorders for OR10H3 Gene

Relevant External Links for OR10H3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR10H3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H3 Gene

Publications for OR10H3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64

Products for OR10H3 Gene

Sources for OR10H3 Gene

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