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OR10H2 Gene

protein-coding   GIFtS: 50
GCID: GC19P015838

Olfactory Receptor, Family 10, Subfamily H, Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily H, Member 21 2
Olfactory Receptor OR19-232 3
Olfactory Receptor 10H22

External Ids:    HGNC: 81731   Entrez Gene: 265382   Ensembl: ENSG000001719427   UniProtKB: O604033   

Export aliases for OR10H2 gene to outside databases

Previous GC identifers: GC19M016330 GC19P016232 GC19P015684 GC19P015699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10H2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10H2 Gene:
OR10H2 (olfactory receptor, family 10, subfamily H, member 2) is a protein-coding gene. GO annotations related to this gene include serotonin receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10H2_HUMAN, O60403
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10H2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10H2 gene promoter:
         Max1   AhR   RFX1   RP58   NRSF form 1   Tal-1beta   NRSF form 2   CREB   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10H2 promoter sequence
   Search Chromatin IP Primers for OR10H2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR10H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10H2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015838:  view genomic region     (about GC identifiers)

Start:
15,838,854 bp from pter      End:
15,839,798 bp from pter
Size:
945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O10H2_HUMAN, O60403 (See protein sequence)
Recommended Name: Olfactory receptor 10H2  
Size: 315 amino acids; 34663 Da
Secondary accessions: Q6IFQ1 Q96R58

Explore the universe of human proteins at neXtProt for OR10H2: NX_O60403

Explore proteomics data for OR10H2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR10H2

    See OR10H2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_039227.1  
    ENSEMBL proteins: 
     ENSP00000306095  
    Reactome Protein details: O60403

    OR10H2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR019424 7TM_GPCR_olfarory/Srsx
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O60403

    ProtoNet protein and cluster: O60403

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10H2_HUMAN, O60403
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10H2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10H2_HUMAN, O60403
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR10H2:
    olfactory receptor,family 10,subfamily H,member 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR10H2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR10H2

    miRNA
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    miRTarBase miRNAs that target OR10H2:
    hsa-mir-26b-5p (MIRT029003)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10H2_HUMAN, O60403: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR10H2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10H2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR10H2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR10H2
        GPCRs, Class A Rhodopsin-like


    1 Reactome Pathway for OR10H2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10H2):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10H2
    Interactions:

        Search GeneGlobe Interaction Network for OR10H2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10H2 (ENSP000003060954) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    OR1D2ENSP000003275854STRING: ENSP00000327585
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR10H2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10H2 (O10H2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10H2 gene: 
    NM_013939.2  

    Unigene Cluster for OR10H2:

    Olfactory receptor, family 10, subfamily H, member 2
    Hs.247694  [show with all ESTs]
    Unigene Representative Sequence: BC112178
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305899(uc002nbm.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR10H2

    Additional mRNA sequence: 

    BC069085.1 BC069457.1 BC112178.1 BC113647.1 

    1 DOTS entry:

    DT.91749326 

    7 AceView cDNA sequences:

    NM_013939 BC069457 BC069085 BV173409 BG189045 BG197640 BG194244 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR10H2 Expression
    About this image

    OR10H2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10H2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247694
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10H2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm44615 predicted gene 4461   --   17 (17.98 cM) 33215261 


    ENSEMBL Gene Tree for OR10H2 (if available)
    TreeFam Gene Tree for OR10H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10H2 gene
    OR10H42  OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  
    OR10H12  OR10J32  OR10R22  OR10H32  OR10K12  OR10J12  
    Selected SIMAP similar genes for OR10H2 using alignment to 1 protein entry:     O10H2_HUMAN(see all similar genes):
    OR10H1    OR10H5    OR10H3    OR10H4    OR10R3P    OR10J4
    OR10K1    OR10T2    OR10X1    OR10J1    OR10R2    OR10Z1
    OR10J5    OR10A2    OR10A5    OR10K2    OR13D1    OR13G1

    Find genes that share paralogs with OR10H2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10H2 (see all 147)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455812301,2
    --15837004(+) AACTTC/TTGTAT 1 -- us2k10--------
    rs1133315601,2
    F--15837125(+) TCCTAT/CTGGTG 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs1906025561,2
    --15837165(+) TTGGGC/TAGATC 1 -- us2k10--------
    rs124596961,2
    C,F,H--15837175(+) CTGACT/CCTGTG 1 -- us2k111Minor allele frequency- C:0.24NS EA NA 844
    rs1406880241,2
    --15837235(+) TTGCTA/GTTAGG 1 -- us2k10--------
    rs1819027101,2
    --15837285(+) GGAGAA/CCAGCA 1 -- us2k10--------
    rs72515451,2
    C,F,A,H--15837464(+) ccgagC/Aaacat 1 -- us2k18Minor allele frequency- A:0.35NA WA CSA EA 368
    rs72516591,2
    C,F,A,H--15837522(+) tgatgC/Tgggcc 1 -- us2k1 tfbs39Minor allele frequency- T:0.39NA CSA EA 253
    rs1864290421,2
    --15837600(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs72520501,2
    C,A,H--15837820(+) gccagG/Cagtgc 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for OR10H2 ( 15838854 - 15839798 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OR10H2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470128CNV Gain18288195
    nsv911139CNV Gain21882294
    dgv137e55CNV Gain17911159
    nsv526168CNV Gain19592680
    dgv1059e1CNV Complex17122850
    esv3260OTHER Inversion18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10H2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26538 HGNC: 8173 AceView: OR10H2 Ensembl:ENSG00000171942 euGenes: HUgn26538
    ECgene: OR10H2 Kegg: 26538 H-InvDB: OR10H2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10H2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10H2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10H2 gene:
    Search GeneIP for patents involving OR10H2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Antibodies for OR10H2   OriGene RNAi products in human, mouse, rat for OR10H2  
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     OriGene Custom Antibody Services for OR10H2   OriGene Custom Protein Services for OR10H2  

     
     
     Block miRNA regulation of human, mouse, rat OR10H2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR10H2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10H2 Predesigned siRNA for gene silencing in human, mouse, rat OR10H2
     QuantiFast Probe-based Assays in human, mouse, rat OR10H2 QuantiTect SYBR Green Assays in human, mouse, rat OR10H2
     Custom PCR Arrays for OR10H2 Search Chromatin IP Primers for OR10H2
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     Regulatory tfbs in OR10H2 promoter
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     Search Tocris compounds for OR10H2 (O10H2)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR10H2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR10H2
     Browse compounds at ApexBio
     Search Addgene for plasmids for OR10H2
      Search eBioscience for proteins for OR10H2
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OR10H2
     antibodies-online antibodies for OR10H2 (10 products)
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      Search antibodies-online for peptides for OR10H2
     antibodies-online proteins for OR10H2 (3 products)
           
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