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Aliases for OR10H2 Gene

Aliases for OR10H2 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 2 2 3 5
  • Olfactory Receptor, Family 10, Subfamily H, Member 2 2
  • Olfactory Receptor OR19-23 4

External Ids for OR10H2 Gene

Previous GeneCards Identifiers for OR10H2 Gene

  • GC19M016330
  • GC19P016232
  • GC19P015684
  • GC19P015699
  • GC19P015838

Summaries for OR10H2 Gene

Entrez Gene Summary for OR10H2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H2 Gene

OR10H2 (Olfactory Receptor Family 10 Subfamily H Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H5.

UniProtKB/Swiss-Prot for OR10H2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H2 Gene

Additional gene information for OR10H2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H2 Gene

Genomics for OR10H2 Gene

Regulatory Elements for OR10H2 Gene

Enhancers for OR10H2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H016063 1.9 FANTOM5 ENCODE dbSUPER 15.6 +344.9 344894 18.7 FEZF1 DMAP1 ZNF143 SP3 MCM3 MEF2D SSRP1 GLIS1 RCOR2 NBN AKAP8 CHERP ENSG00000269578 BRD4 C19orf44 ENSG00000267904 ENSG00000268087 TPM4 SMIM7 OR10H5
GH19H016110 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +388.2 388156 11 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 YBX1 ZNF2 YY1 CHERP AKAP8 ENSG00000268743 BRD4 C19orf44 ENSG00000269578 ENSG00000267904 ENSG00000268087 MED26 LINC01855
GH19H015123 1.4 ENCODE dbSUPER 14.6 -602.8 -602769 3.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AKAP8 BRD4 ZNF333 TPM4 AKAP8L OR10H2 OR1AB1P LINC01855 OR10H5 LINC00905
GH19H015416 1.4 ENCODE dbSUPER 14.6 -309.6 -309609 3.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 AKAP8 ZNF333 TPM4 BRD4 OR10H2 OR10H5 LINC00905 LINC01855 OR1AB1P DDX39A
GH19H016626 1.4 ENCODE dbSUPER 14.6 +900.5 900497 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 SMIM7 C19orf44 LINC00905 LINC01855 OR1AB1P OR10H5 OR10H2 SLC35E1 TMEM38A ENSG00000269044
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10H2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR10H2 Gene

Genomic Locations for OR10H2 Gene
1,041 bases
Plus strand

Genomic View for OR10H2 Gene

Genes around OR10H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H2 Gene

Proteins for OR10H2 Gene

  • Protein details for OR10H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10H2
    Protein Accession:
    Secondary Accessions:
    • Q6IFQ1
    • Q96R58

    Protein attributes for OR10H2 Gene

    315 amino acids
    Molecular mass:
    34663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H2 Gene

Post-translational modifications for OR10H2 Gene

No Post-translational modifications

Other Protein References for OR10H2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H2 Gene

Domains & Families for OR10H2 Gene

Gene Families for OR10H2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H2 Gene

Suggested Antigen Peptide Sequences for OR10H2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H2: view

Function for OR10H2 Gene

Molecular function for OR10H2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10H2 Gene

Gene Ontology (GO) - Molecular Function for OR10H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H2: view
genes like me logo Genes that share phenotypes with OR10H2: view

miRNA for OR10H2 Gene

miRTarBase miRNAs that target OR10H2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H2 Gene

Localization for OR10H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10H2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H2 Gene

Pathways & Interactions for OR10H2 Gene

genes like me logo Genes that share pathways with OR10H2: view

Pathways by source for OR10H2 Gene

1 BioSystems pathway for OR10H2 Gene
1 KEGG pathway for OR10H2 Gene

Interacting Proteins for OR10H2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: O60403-O10H2_HUMAN ENSP00000306095 for OR10H2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR10H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H2: view

No data available for SIGNOR curated interactions for OR10H2 Gene

Drugs & Compounds for OR10H2 Gene

No Compound Related Data Available

Transcripts for OR10H2 Gene

mRNA/cDNA for OR10H2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10H2 Gene

Olfactory receptor, family 10, subfamily H, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H2 Gene

No ASD Table

Relevant External Links for OR10H2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10H2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H2 Gene:


SOURCE GeneReport for Unigene cluster for OR10H2 Gene:

genes like me logo Genes that share expression patterns with OR10H2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H2 Gene

Orthologs for OR10H2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468755 33
  • 98.31 (n)
OR10H2 34
  • 97 (a)
(Bos Taurus)
Mammalia LOC532441 33
  • 85.78 (n)
-- 34
  • 83 (a)
-- 34
  • 83 (a)
OR10H1 34
  • 83 (a)
-- 34
  • 81 (a)
-- 34
  • 81 (a)
(Canis familiaris)
Mammalia -- 34
  • 84 (a)
-- 34
  • 83 (a)
-- 34
  • 80 (a)
(Mus musculus)
Mammalia Olfr239 34
  • 84 (a)
Olfr55 34
  • 83 (a)
Gm4461 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Olr1091 33
  • 82.73 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 73 (a)
-- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
Species where no ortholog for OR10H2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H2 Gene

Gene Tree for OR10H2 (if available)
Gene Tree for OR10H2 (if available)

Paralogs for OR10H2 Gene

(448) SIMAP similar genes for OR10H2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10H2: view

Variants for OR10H2 Gene

Sequence variations from dbSNP and Humsavar for OR10H2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1002258663 -- 15,727,717(+) GAACA(A/G)AGGCA upstream-variant-2KB
rs1002311012 -- 15,727,946(+) GGAGG(C/T)GCTCT upstream-variant-2KB
rs1003930335 -- 15,727,026(+) GGTCA(A/G)AGATG upstream-variant-2KB
rs1004157536 -- 15,726,488(+) GTCAC(A/G)TAGTG upstream-variant-2KB
rs1004282360 -- 15,726,746(+) CGGAG(A/G)CAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10H2 Gene

Variant ID Type Subtype PubMed ID
nsv526168 CNV gain 19592680
nsv470128 CNV gain 18288195
nsv1153107 OTHER inversion 26484159
nsv1141884 OTHER inversion 24896259
nsv1133007 OTHER inversion 24896259
nsv1079032 OTHER inversion 25765185
nsv1064684 CNV gain 25217958
nsv1061046 CNV gain 25217958
esv3334671 CNV duplication 20981092
esv3260 OTHER inversion 18987735
esv2758747 CNV gain+loss 17122850
dgv3454n100 CNV gain 25217958
dgv137e55 CNV gain 17911159

Variation tolerance for OR10H2 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.41; 95.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10H2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H2 Gene

Disorders for OR10H2 Gene

Relevant External Links for OR10H2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR10H2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H2 Gene

Publications for OR10H2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  5. Exome sequencing reveals new causal mutations in children with epileptic encephalopathies. (PMID: 23647072) Veeramah KR … Hammer MF (Epilepsia 2013) 4 60

Products for OR10H2 Gene

Sources for OR10H2 Gene

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