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OR10G9 Gene

protein-coding   GIFtS: 42
GCID: GC11P123893

Olfactory Receptor, Family 10, Subfamily G, Member 9


(Previous symbol: OR10G10P)
  Search for OR10G9
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily G, Member 91 2
OR10G10P1 2 3
Olfactory Receptor 10G102 3
Olfactory Receptor 10G92
Olfactory Receptor OR11-2722

External Ids:    HGNC: 151291   Entrez Gene: 2198702   Ensembl: ENSG000002369817   UniProtKB: Q8NGN43   

Export aliases for OR10G9 gene to outside databases

Previous GC identifers: GC11U990584 GC11P123398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10G9 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10G9 Gene:
OR10G9 (olfactory receptor, family 10, subfamily G, member 9) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G2.

UniProtKB/Swiss-Prot: O10G9_HUMAN, Q8NGN4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10G9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10G9 gene promoter:
         AREB6   AhR   PPAR-alpha   AML1a   CP2   LCR-F1   GATA-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10G9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

OR10G9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10G9 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P123893:  view genomic region     (about GC identifiers)

Start:
123,893,720 bp from pter      End:
123,894,652 bp from pter
Size:
933 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: O10G9_HUMAN, Q8NGN4 (See protein sequence)
Recommended Name: Olfactory receptor 10G9  
Size: 311 amino acids; 34574 Da

Explore the universe of human proteins at neXtProt for OR10G9: NX_Q8NGN4

Explore proteomics data for OR10G9 at MOPED

HORDE protein sequence for OR10G9

See OR10G9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001953.1  
ENSEMBL proteins: 
 ENSP00000364164  
Reactome Protein details: Q8NGN4

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR10: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGN4

ProtoNet protein and cluster: Q8NGN4

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10G9_HUMAN, Q8NGN4
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR10G9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O10G9_HUMAN, Q8NGN4
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR10G9           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O10G9_HUMAN, Q8NGN4: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with OR10G9           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR10G9 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with OR10G9           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR10G9
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR10G9):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR10G9

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR10G9 (ENSP000003641644) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
GNALENSP000003340514STRING: ENSP00000334051
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OR10G9 (O10G9)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR10G9 gene: 
NM_001001953.1  

Unigene Cluster for OR10G9:

Olfactory receptor, family 10, subfamily G, member 9
Hs.553636
Unigene Representative Sequence: NM_001001953
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000375024(uc010sad.2)
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1 AceView cDNA sequence:

NM_001001953 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR10G9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGAGTGGGA
OR10G9 Expression
About this image

OR10G9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR10G9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553636
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR10G9 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr9791 , 5 olfactory receptor 9791, 5 85.1(n)1
86.5(a)1
  9 (21.28 cM)5
2591121  NM_147108.21  NP_667319.11 
 400002065 


ENSEMBL Gene Tree for OR10G9 (if available)
TreeFam Gene Tree for OR10G9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR10G9 gene
OR10G22  OR10S12  OR10G62  OR10G32  OR10D32  OR10G72  OR10G42  OR10G82  
Selected SIMAP similar genes for OR10G9 using alignment to 1 protein entry:     O10G9_HUMAN(see all similar genes):
OR10G4    OR10G7    OR10G8    OR10G2    OR10G3    OR4Q2
OR10S1    OR10D4P    OR4D1    OR10D3    OR10G6    OR2J4P
OR4B1    OR4D11    OR4D5    OR4D9    OR5AP2    OR5B21

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR10G9 (see all 167)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs756743251,2
C--123891799(+) CGTAGC/ATTAAG 1 -- us2k13Minor allele frequency- A:0.13CSA WA EA 240
rs1383111241,2
--123891815(+) TTCCCC/TGGAGG 1 -- us2k10--------
rs1895944331,2
--123892019(+) CATAGA/GCCTCT 1 -- us2k10--------
rs1120686021,2
C,F--123892040(+) TGGTCC/TCATTT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
rs1469056381,2
--123892074(+) CTTAAC/TTGAGA 1 -- us2k10--------
rs1807801901,2
--123892075(+) TTAATC/TGAGAG 1 -- us2k10--------
rs1851995451,2
C--123892464(+) TAAAAA/GCAGGC 1 -- us2k10--------
rs13187501,2
C,F,A,H--123892491(-) GATACT/AGTTAC 1 -- us2k116Minor allele frequency- A:0.31NS EA WA NA CSA 1203
rs112194111,2
C,F,H--123892506(+) ATACAA/GTAGTA 1 -- us2k118Minor allele frequency- G:0.33NS EA NA CSA WA 2337
rs1907974971,2
--123892546(+) TCTCTA/GAAAAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR10G9 ( 123893720 - 123894652 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR10G9:    About this table    
Variant IDTypeSubtypePubMed ID
esv2582148CNV Deletion19546169
nsv898435CNV Gain21882294
dgv82n21CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for OR10G9 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR10G9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 219870 HGNC: 15129 AceView: OR10G9 Ensembl:ENSG00000236981 euGenes: HUgn219870
ECgene: OR10G9 Kegg: 219870 H-InvDB: OR10G9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR10G9 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR10G9 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR10G9 gene:
Search GeneIP for patents involving OR10G9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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