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Aliases for OR10G4 Gene

Aliases for OR10G4 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 4 2 3 5
  • Olfactory Receptor OR11-278 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 4 2
  • Olfactory Receptor 10G4 3
  • OR11-278 3

External Ids for OR10G4 Gene

Previous GeneCards Identifiers for OR10G4 Gene

  • GC11U990358
  • GC11P123424
  • GC11P123391
  • GC11P123886

Summaries for OR10G4 Gene

Entrez Gene Summary for OR10G4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G4 Gene

OR10G4 (Olfactory Receptor Family 10 Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G9.

UniProtKB/Swiss-Prot for OR10G4 Gene

  • Odorant receptor.

Gene Wiki entry for OR10G4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10G4 Gene

Genomics for OR10G4 Gene

Regulatory Elements for OR10G4 Gene

Enhancers for OR10G4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F123695 0.4 FANTOM5 13.7 -320.2 -320242 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11F124008 0.3 FANTOM5 13.2 -6.9 -6901 0.4 OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2 OR6X1
GH11F123583 0.3 FANTOM5 8.7 -431.7 -431707 0.4 ATF1 SIN3A FEZF1 ETV6 FOS ZEB2 ELF1 MAFF ZSCAN16 IKZF1 OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 GC11M123576 GC11M123593
GH11F123740 0.9 FANTOM5 ENCODE 8.2 -273.5 -273502 3.8 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263 SP3 ZNF202 OR6X1 OR10G7 OR6M1 OR10G4 OR8G2 OR4D5 TMEM225 OR6T1 OR8D4
GH11F124191 0.8 FANTOM5 2.3 +176.5 176515 0.3 DDX20 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2 OR8B12 OR4D5 OR10G4 OR6M1 OR8G1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR10G4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10G4 Gene

Chromosome:
11
Start:
124,015,575 bp from pter
End:
124,016,510 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR10G4 Gene

Genes around OR10G4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G4 Gene

Proteins for OR10G4 Gene

  • Protein details for OR10G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN3-O10G4_HUMAN
    Recommended name:
    Olfactory receptor 10G4
    Protein Accession:
    Q8NGN3
    Secondary Accessions:
    • Q6IEW0

    Protein attributes for OR10G4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G4 Gene

Post-translational modifications for OR10G4 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10G4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G4 Gene

Domains & Families for OR10G4 Gene

Gene Families for OR10G4 Gene

Protein Domains for OR10G4 Gene

Suggested Antigen Peptide Sequences for OR10G4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGN3

UniProtKB/Swiss-Prot:

O10G4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G4: view

Function for OR10G4 Gene

Molecular function for OR10G4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10G4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G4 Gene

Localization for OR10G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10G4 Gene COMPARTMENTS Subcellular localization image for OR10G4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10G4: view

Pathways & Interactions for OR10G4 Gene

genes like me logo Genes that share pathways with OR10G4: view

Pathways by source for OR10G4 Gene

Interacting Proteins for OR10G4 Gene

Gene Ontology (GO) - Biological Process for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G4: view

No data available for SIGNOR curated interactions for OR10G4 Gene

Transcripts for OR10G4 Gene

mRNA/cDNA for OR10G4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G4 Gene

No ASD Table

Relevant External Links for OR10G4 Gene

GeneLoc Exon Structure for
OR10G4
ECgene alternative splicing isoforms for
OR10G4

Expression for OR10G4 Gene

mRNA expression in normal human tissues for OR10G4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10G4 Gene

This gene is overexpressed in Pancreas (x38.6), Testis (x7.5), and Colon - Transverse (x6.9).

Protein differential expression in normal tissues from HIPED for OR10G4 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR10G4 Gene



Protein tissue co-expression partners for OR10G4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10G4 Gene:

OR10G4

SOURCE GeneReport for Unigene cluster for OR10G4 Gene:

Hs.553760
genes like me logo Genes that share expression patterns with OR10G4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR10G4 Gene

Orthologs for OR10G4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 86 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr979 35
  • 86 (a)
ManyToMany
Olfr978 35
  • 85 (a)
ManyToMany
Olfr980 34 16 35
  • 84.95 (n)
rat
(Rattus norvegicus)
Mammalia Olr1335 34
  • 83.76 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
Species where no ortholog for OR10G4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10G4 Gene

ENSEMBL:
Gene Tree for OR10G4 (if available)
TreeFam:
Gene Tree for OR10G4 (if available)

Paralogs for OR10G4 Gene

Paralogs for OR10G4 Gene

(449) SIMAP similar genes for OR10G4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10G4: view

Variants for OR10G4 Gene

Sequence variations from dbSNP and Humsavar for OR10G4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10502277 -- 124,014,274(-) TTGTG(A/G)ACTAT upstream-variant-2KB
rs111274057 -- 124,016,023(+) GCTCA(A/G)TGGCT reference, missense
rs11219407 -- 124,015,601(+) ACAGC(A/G)TTCAT reference, synonymous-codon
rs11219408 -- 124,016,251(+) CCTGC(A/G)GATCC reference, missense
rs112431396 -- 124,016,400(+) TCTAC(A/G)CTGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR10G4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2582148 CNV deletion 19546169
nsv983070 CNV duplication 23825009

Variation tolerance for OR10G4 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.27; 99.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10G4 Gene

Human Gene Mutation Database (HGMD)
OR10G4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10G4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G4 Gene

Disorders for OR10G4 Gene

Relevant External Links for OR10G4

Genetic Association Database (GAD)
OR10G4
Human Genome Epidemiology (HuGE) Navigator
OR10G4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10G4

No disorders were found for OR10G4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G4 Gene

Publications for OR10G4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. The missense of smell: functional variability in the human odorant receptor repertoire. (PMID: 24316890) Mainland J.D. … Matsunami H. (Nat. Neurosci. 2014) 3 64

Products for OR10G4 Gene

Sources for OR10G4 Gene

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