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Aliases for OR10G4 Gene

Aliases for OR10G4 Gene

  • Olfactory Receptor, Family 10, Subfamily G, Member 4 2 3
  • Olfactory Receptor OR11-278 3 4
  • Olfactory Receptor 10G4 3
  • OR11-278 3

External Ids for OR10G4 Gene

Summaries for OR10G4 Gene

Entrez Gene Summary for OR10G4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G4 Gene

OR10G4 (Olfactory Receptor, Family 10, Subfamily G, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10D3.

UniProtKB/Swiss-Prot for OR10G4 Gene

  • Odorant receptor.

Gene Wiki entry for OR10G4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10G4 Gene

Genomics for OR10G4 Gene

Genomic Location for OR10G4 Gene

Start:
124,015,575 bp from pter
End:
124,016,510 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR10G4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G4 Gene

Regulatory Elements for OR10G4 Gene

Proteins for OR10G4 Gene

  • Protein details for OR10G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN3-O10G4_HUMAN
    Recommended name:
    Olfactory receptor 10G4
    Protein Accession:
    Q8NGN3
    Secondary Accessions:
    • Q6IEW0

    Protein attributes for OR10G4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G4 Gene

Proteomics data for OR10G4 Gene at MOPED

Post-translational modifications for OR10G4 Gene

Other Protein References for OR10G4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10G4 Gene

Domains for OR10G4 Gene

Gene Families for OR10G4 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10G4 Gene

UniProtKB/Swiss-Prot:

O10G4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGN3
genes like me logo Genes that share domains with OR10G4: view

Function for OR10G4 Gene

Molecular function for OR10G4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10G4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10G4 Gene

Localization for OR10G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10G4 Gene COMPARTMENTS Subcellular localization image for OR10G4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10G4: view

Pathways for OR10G4 Gene

genes like me logo Genes that share pathways with OR10G4: view

Pathways by source for OR10G4 Gene

Interacting Proteins for OR10G4 Gene

Gene Ontology (GO) - Biological Process for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G4: view

Transcripts for OR10G4 Gene

mRNA/cDNA for OR10G4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G4 Gene

No ASD Table

Relevant External Links for OR10G4 Gene

GeneLoc Exon Structure for
OR10G4
ECgene alternative splicing isoforms for
OR10G4

Expression for OR10G4 Gene

mRNA expression in normal human tissues for OR10G4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10G4 Gene

This gene is overexpressed in Pancreas (38.6), Testis (7.5), and Colon - Transverse (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR10G4 Gene

SOURCE GeneReport for Unigene cluster for OR10G4 Gene Hs.553760

genes like me logo Genes that share expressions with OR10G4: view

Orthologs for OR10G4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 80 (a)
ManyToMany
-- 37
  • 82 (a)
ManyToMany
-- 37
  • 82 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
-- 37
  • 80 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 85 (a)
ManyToMany
-- 37
  • 86 (a)
ManyToMany
-- 37
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr978 37
  • 85 (a)
ManyToMany
Olfr979 37
  • 86 (a)
ManyToMany
Olfr980 36
  • 84.95 (n)
  • 85.48 (a)
Olfr980 16
Olfr980 37
  • 85 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 72 (a)
ManyToMany
-- 37
  • 72 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1335 36
  • 83.76 (n)
  • 84.52 (a)
Species with no ortholog for OR10G4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10G4 Gene

ENSEMBL:
Gene Tree for OR10G4 (if available)
TreeFam:
Gene Tree for OR10G4 (if available)

Paralogs for OR10G4 Gene

Paralogs for OR10G4 Gene

Selected SIMAP similar genes for OR10G4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10G4: view

Variants for OR10G4 Gene

Sequence variations from dbSNP and Humsavar for OR10G4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs503223 -, -, - 124,016,010(+) CCACC(A/G)GCACT missense, reference
rs517598 -- 124,016,607(-) AATAA(A/T)GTTTA downstream-variant-500B
rs547068 - 124,015,645(-) AGAGG(A/G)GGGCG missense, reference
rs547870 -- 124,015,583(-) CTGGC(A/C/G)TTGGA reference, missense, synonymous-codon
rs548703 -- 124,015,518(-) ATTTA(C/G)CACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10G4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV Gain 19592680
nsv898435 CNV Gain 21882294
esv2582148 CNV Deletion 19546169

Relevant External Links for OR10G4 Gene

HapMap Linkage Disequilibrium report
OR10G4
Human Gene Mutation Database (HGMD)
OR10G4

Disorders for OR10G4 Gene

Relevant External Links for OR10G4

Genetic Association Database (GAD)
OR10G4
Human Genome Epidemiology (HuGE) Navigator
OR10G4
genes like me logo Genes that share disorders with OR10G4: view

No data available for UniProtKB/Swiss-Prot for OR10G4 Gene

Publications for OR10G4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. The missense of smell: functional variability in the human odorant receptor repertoire. (PMID: 24316890) Mainland J.D. … Matsunami H. (Nat. Neurosci. 2014) 3

Products for OR10G4 Gene

Sources for OR10G4 Gene

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