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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR10G4 Gene

protein-coding   GIFtS: 45
GCID: GC11P123886

Olfactory Receptor, Family 10, Subfamily G, Member 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 10, Subfamily G, Member 41 2
Olfactory Receptor OR11-2782 3
OR11-2782
Olfactory Receptor 10G42

External Ids:    HGNC: 148091   Entrez Gene: 3902642   Ensembl: ENSG000002547377   UniProtKB: Q8NGN33   

Export aliases for OR10G4 gene to outside databases

Previous GC identifers: GC11U990358 GC11P123424 GC11P123391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR10G4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10G4 Gene: 
OR10G4 (olfactory receptor, family 10, subfamily G, member 4) is a protein-coding gene. Diseases associated with OR10G4 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10S1.

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10G4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR10G4 gene promoter:
         AREB6   AhR   PPAR-alpha   AML1a   FOXO1a   LCR-F1   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR10G4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR10G4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

OR10G4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10G4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P123886:  view genomic region     (about GC identifiers)

Start:
123,886,282 bp from pter      End:
123,887,214 bp from pter
Size:
933 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3 (See protein sequence)
Recommended Name: Olfactory receptor 10G4  
Size: 311 amino acids; 34569 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IEW0

Explore the universe of human proteins at neXtProt for OR10G4: NX_Q8NGN3

Explore proteomics data for OR10G4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NGN3

  • HORDE protein sequence for OR10G4
    OR10G4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR10G4 Protein Expression
    REFSEQ proteins: NP_001004462.1  
    ENSEMBL proteins: 
     ENSP00000325076  
    Reactome Protein details: Q8NGN3
    Human Recombinant Protein Products for OR10G4: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR10G4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGN3

    ProtoNet protein and cluster: Q8NGN3

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR10G4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10G4_HUMAN, Q8NGN3
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR10G4 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR10G4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR10G4
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR10G4):
        Olfactory transduction


    OR10G4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR10G4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR10G4 (ENSP000003250764) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR2AG2ENSP000003426974STRING: ENSP00000342697
    OR2D3ENSP000003205604STRING: ENSP00000320560
    OR5B3ENSP000003082704STRING: ENSP00000308270
    OR5K3ENSP000003731944STRING: ENSP00000373194
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR10G4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR10G4 (O10G4)

    Search CenterWatch for drugs/clinical trials and news about OR10G4 / O10G4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR10G4 gene: 
    NM_001004462.1  

    Unigene Cluster for OR10G4:

    Olfactory receptor, family 10, subfamily G, member 4
    Hs.553760
    Unigene Representative Sequence: NM_001004462
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000320891(uc010sac.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR10G4

    1 AceView cDNA sequence:

    NM_001004462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR10G4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGAGTTG
    OR10G4 Expression
    About this image


    See OR10G4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.553760
        SABiosciences Custom PCR Arrays for OR10G4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10G4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10G4 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr9801 , 5 olfactory receptor 9801, 5 84.95(n)1
    85.48(a)1
      9 (21.29 cM)5
    2591101  NM_147106.21  NP_667317.11 
     400060155 


    ENSEMBL Gene Tree for OR10G4 (if available)
    TreeFam Gene Tree for OR10G4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR10G4 gene
    OR10S12  OR10G22  OR10G92  OR10G32  OR10D32  OR10G72  OR10G82  
    18/450 SIMAP similar genes for OR10G4 using alignment to 1 protein entry:     O10G4_HUMAN(see all similar genes):
    OR10G9    OR10G7    OR10G8    OR10G2    OR10G3    OR4Q2
    OR10S1    OR10D4P    OR4B1    OR4D1    OR5AP2    FKSG35
    OR10D3    OR10G6    OR2J4P    OR4D11    OR4D2    OR4D5

    OR10G4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in OR10G4 are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442616441,2
    Cuntested1123886905(+) TCAGGC/G/TTGCTT 2 G syn11EU 1323
    rs1845319031,2
    --123884336(+) TATCCC/TGGTTT 1 -- us2k10--------
    rs1475992961,2
    --123884411(+) AAGAAA/GACATT 1 -- us2k10--------
    rs65900351,2
    C,F,A,H--123884423(+) TGTATT/GCAGTT 1 -- us2k130Minor allele frequency- G:0.16NA NS EA WA CSA 2906
    rs1903204331,2
    --123884456(+) TACCAA/CTTGTA 1 -- us2k10--------
    rs762662851,2
    C--123884547(+) AGGTAG/TTAAAA 1 -- us2k10--------
    rs1420765911,2
    --123884660(+) CGAAGC/TCAATA 1 -- us2k10--------
    rs1824962451,2
    --123884718(+) CTAGCC/GCCTAT 1 -- us2k10--------
    rs1512180091,2
    --123884720(+) AGCCCC/TTATCT 1 -- us2k10--------
    rs570940861,2
    C--123884856(+) GGTGGG/AAGGTT 1 -- us2k15Minor allele frequency- A:0.12CSA WA NA EA 361

    HapMap Linkage Disequilibrium report for OR10G4 ( 123886282 - 123887214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR10G4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2582148CNV Deletion19546169
    nsv898435CNV Gain21882294
    dgv82n21CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR10G4:    About MalaCards
    neuronitis    


    OR10G4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR10G4
    Human Genome Epidemiology (HuGE) Navigator: OR10G4 (1 document)

    Export disorders for OR10G4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR10G4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR10G4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390264 HGNC: 14809 AceView: OR10G4 Ensembl:ENSG00000254737 euGenes: HUgn390264
    ECgene: OR10G4 Kegg: 390264 H-InvDB: OR10G4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR10G4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10G4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR10G4 gene:
    Search GeneIP for patents involving OR10G4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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