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Aliases for OR10C1 Gene

Aliases for OR10C1 Gene

  • Olfactory Receptor Family 10 Subfamily C Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 10, Subfamily C, Member 2 2 3
  • Olfactory Receptor, Family 10, Subfamily C, Member 1 2 3
  • Olfactory Receptor 10C2 3 4
  • Hs6M1-17 3 4
  • OR10C2 3 4
  • Olfactory Receptor, Family 10, Subfamily C, Member 1 (Gene/Pseudogene) 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor OR6-31 3
  • Olfactory Receptor 10C1 3
  • OR10C1P 3
  • OR6-31 3

External Ids for OR10C1 Gene

Previous HGNC Symbols for OR10C1 Gene

  • OR10C2

Previous GeneCards Identifiers for OR10C1 Gene

  • GC06P029465
  • GC06U900299
  • GC06P029493
  • GC06P029517
  • GC06P029407
  • GC06Po29337

Summaries for OR10C1 Gene

Entrez Gene Summary for OR10C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR10C1 Gene

OR10C1 (Olfactory Receptor Family 10 Subfamily C Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A4.

UniProtKB/Swiss-Prot for OR10C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10C1 Gene

Genomics for OR10C1 Gene

Regulatory Elements for OR10C1 Gene

Enhancers for OR10C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028586 1.2 ENCODE 16.2 -852.1 -852141 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GPX6 GPX5 ZNF603P ZNF90P2 KRT18P1 OR2W1 OR2AD1P OR2P1P ENSG00000228364 OR2B3
GH06F030065 1.2 ENCODE 16.2 +627.5 627500 3.0 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 HCG4P3 PPP1R10 IFITM4P HLA-A TRIM26 PAIP1P1 RPL7P4 HCG4P7 HLA-P UBQLN1P1
GH06F030194 1.1 ENCODE 16.2 +756.0 756022 1.6 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 MXD4 ZHX2 HCG18 GTF2H4 PPP1R10 ETF1P1 DHX16 PAIP1P1 ZNRD1ASP HCG4P7 TRIM31 GNL1
GH06F029467 0.3 FANTOM5 19.3 +28.4 28394 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06F029509 0.5 FANTOM5 10.6 +70.0 70004 0.1 IKZF1 EBF1 RELA LINC01015 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 PIRC24 LOC105375009
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10C1 Gene

Chromosome:
6
Start:
29,439,306 bp from pter
End:
29,440,977 bp from pter
Size:
1,672 bases
Orientation:
Plus strand

Genomic View for OR10C1 Gene

Genes around OR10C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR10C1 Gene

  • Protein details for OR10C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KK4-O10C1_HUMAN
    Recommended name:
    Olfactory receptor 10C1
    Protein Accession:
    Q96KK4
    Secondary Accessions:
    • Q5SUN7
    • Q96R18

    Protein attributes for OR10C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34384 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB44507.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR10C1 Gene

Post-translational modifications for OR10C1 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10C1 Gene

Domains & Families for OR10C1 Gene

Gene Families for OR10C1 Gene

Protein Domains for OR10C1 Gene

Suggested Antigen Peptide Sequences for OR10C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KK4

UniProtKB/Swiss-Prot:

O10C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10C1: view

Function for OR10C1 Gene

Molecular function for OR10C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily C,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR10C1: view

Phenotypes for OR10C1 Gene

GenomeRNAi human phenotypes for OR10C1:
genes like me logo Genes that share phenotypes with OR10C1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10C1 Gene

Localization for OR10C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR10C1: view

Pathways & Interactions for OR10C1 Gene

genes like me logo Genes that share pathways with OR10C1: view

Pathways by source for OR10C1 Gene

Interacting Proteins for OR10C1 Gene

Gene Ontology (GO) - Biological Process for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10C1: view

No data available for SIGNOR curated interactions for OR10C1 Gene

Transcripts for OR10C1 Gene

mRNA/cDNA for OR10C1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10C1 Gene

No ASD Table

Relevant External Links for OR10C1 Gene

GeneLoc Exon Structure for
OR10C1
ECgene alternative splicing isoforms for
OR10C1

Expression for OR10C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10C1 Gene:

OR10C1

SOURCE GeneReport for Unigene cluster for OR10C1 Gene:

Hs.631997
genes like me logo Genes that share expression patterns with OR10C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR10C1 Gene

Orthologs for OR10C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471942 34
  • 98.82 (n)
OR10C1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10C1 34 35
  • 85.58 (n)
dog
(Canis familiaris)
Mammalia LOC100856344 34
  • 84.24 (n)
OR10C1 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or10c1 55 Olfr95 34 16 35
  • 82.05 (n)
Or10al5 55 Olfr121
  • chr17:37,751,856-37,752,818
Or10am5 55 Olfr1349
  • chr7:6,514,477-6,515,637
rat
(Rattus norvegicus)
Mammalia Olr1744 34
  • 80.88 (n)
oppossum
(Monodelphis domestica)
Mammalia OR10C1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia OR10C1 35
  • 48 (a)
OneToOne
Species where no ortholog for OR10C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10C1 Gene

ENSEMBL:
Gene Tree for OR10C1 (if available)
TreeFam:
Gene Tree for OR10C1 (if available)

Paralogs for OR10C1 Gene

Paralogs for OR10C1 Gene

(447) SIMAP similar genes for OR10C1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR10C1: view

Variants for OR10C1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR10C1 Gene

O10C1_HUMAN-Q96KK4
A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Sequence variations from dbSNP and Humsavar for OR10C1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10946991 -- 29,440,777(+) ACCGC(A/C)CTCTT intron-variant, reference, synonymous-codon
rs112490646 -- 29,439,216(+) TTTGA(C/T)AGTGT intron-variant, upstream-variant-2KB
rs113865688 -- 29,440,921(+) AAGAG(A/G)ACCAT intron-variant, reference, synonymous-codon
rs115259539 -- 29,441,331(+) CATTT(C/G)TTTCT intron-variant, downstream-variant-500B
rs116786163 -- 29,438,778(+) AGACA(A/T)CAAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10C1 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV loss 17160897
nsv1145096 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185

Variation tolerance for OR10C1 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.21; 92.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10C1 Gene

Human Gene Mutation Database (HGMD)
OR10C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10C1

Disorders for OR10C1 Gene

Relevant External Links for OR10C1

Genetic Association Database (GAD)
OR10C1
Human Genome Epidemiology (HuGE) Navigator
OR10C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10C1

No disorders were found for OR10C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10C1 Gene

Publications for OR10C1 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson E.E. … Ober C. (Hum. Immunol. 2010) 3 46 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 64

Products for OR10C1 Gene

Sources for OR10C1 Gene

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