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OR10C1 Gene

protein-coding   GIFtS: 50
GCID: GC06P029407

Olfactory Receptor, Family 10, Subfamily C, Member 1 (Gene/Pseudogene)

(Previous names: olfactory receptor, family 10, subfamily C, member 2, olfactory...)
(Previous symbol: OR10C2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily C, Member 1
(Gene/Pseudogene)1
     OR6-312
OR10C21 2 3     hs6M1-172
Olfactory Receptor, Family 10, Subfamily C, Member 11 2     Olfactory Receptor 10C12
Olfactory Receptor, Family 10, Subfamily C, Member 21 2     Olfactory Receptor OR6-312
Olfactory Receptor 10C22 3     Seven Transmembrane Helix Receptor2
OR10C1P2     Hs6M1-173

External Ids:    HGNC: 81651   Entrez Gene: 4421942   Ensembl: ENSG000002064747   UniProtKB: Q96KK43   

Export aliases for OR10C1 gene to outside databases

Previous GC identifers: GC06P029465 GC06U900299 GC06P029493 GC06P029517 GC06Po29337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10C1 Gene:
OR10C1 (olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10P1.

UniProtKB/Swiss-Prot: O10C1_HUMAN, Q96KK4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10C1 gene promoter:
         Nkx3-1   Nkx3-1 v4   SREBP-1c   Nkx3-1 v1   SREBP-1b   AREB6   Nkx3-1 v2   SREBP-1a   Nkx3-1 v3   SEF-1 (1)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR10C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.2-p21.31

OR10C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10C1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029407:  view genomic region     (about GC identifiers)

Start:
29,407,793 bp from pter      End:
29,408,728 bp from pter
Size:
936 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167247 710,893-711,931      Chr6+,NT_167246 710,694-711,732      Chr6+,NT_167245 711,046-712,084     
Chr6+,NT_167248 711,004-712,042      Chr6+,NT_167249 748,248-749,286      Chr6+,NT_113891.2 926,494-927,532     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O10C1_HUMAN, Q96KK4 (See protein sequence)
Recommended Name: Olfactory receptor 10C1  
Size: 312 amino acids; 34384 Da
Sequence caution: Sequence=CAB44507.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5SUN7 Q96R18

Explore the universe of human proteins at neXtProt for OR10C1: NX_Q96KK4

Explore proteomics data for OR10C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • HORDE protein sequence for OR10C1

    See OR10C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_039229.3  
    ENSEMBL proteins: 
     ENSP00000419119  
    Reactome Protein details: Q96KK4

    OR10C1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR10C1

     
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    Search eBioscience for ELISAs for OR10C1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96KK4

    ProtoNet protein and cluster: Q96KK4

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10C1_HUMAN, Q96KK4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10C1_HUMAN, Q96KK4
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR10C1:
    olfactory receptor,family 10,subfamily C,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR10C1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR10C1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10C1_HUMAN, Q96KK4: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR10C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR10C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR10C1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10C1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10C1
    Interactions:

        Search GeneGlobe Interaction Network for OR10C1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR10C1 (ENSP000004191194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR10C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10C1 (O10C1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10C1 gene: 
    NM_013941.3  

    Unigene Cluster for OR10C1:

    Olfactory receptor, family 10, subfamily C, member 1
    Hs.631997
    Unigene Representative Sequence: NM_013941
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000444197(uc011dlp.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR10C1
      QuantiFast Probe-based Assays in human, mouse, rat OR10C1

    Additional mRNA sequence: 

    AJ459860.1 BC136996.1 BC136997.1 

    1 AceView cDNA sequence:

    AJ459860 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTATGACC
    OR10C1 Expression
    About this image

    OR10C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631997
        Custom PCR Arrays for OR10C1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR10C1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr951 , 5 olfactory receptor 951, 5 82.05(n)1
    85.9(a)1
      17 (19.16 cM)5
    2585061  NM_146513.11  NP_666724.11 
     372108945 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    42(a)
    many ↔ many
    10(318629-319594)
    lizard
    (Anolis carolinensis)
    Reptilia OR10C16
    olfactory receptor, family 10, subfamily C, member...
    48(a)
    1 ↔ 1
    GL343253.1(565120-566049)


    ENSEMBL Gene Tree for OR10C1 (if available)
    TreeFam Gene Tree for OR10C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10C1 gene
    OR10P12  OR10A32  OR10AG12  OR10A72  OR10A22  OR10A42  OR10A62  OR10A52  
    Selected SIMAP similar genes for OR10C1 using alignment to 2 protein entries:     O10C1_HUMAN (see all proteins) (see all similar genes):
    OR10A4    OR10A7    OR10A2    OR10A3    OR10A5    OR10R3P
    OR8U8    OR2T11    OR5A2    OR5AR1    OR8U9    6M1-16
    OR10A6    OR10AG1    OR10P1    OR13C8    OR1M1    OR2AJ1

    Find genes that share paralogs with OR10C1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    O10C1_HUMAN, Q96KK4: A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional
    diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans


    Selected SNPs for OR10C1 (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557405521,2
    C,F--29405888(+) TAAATT/GTATTA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1837018221,2
    C--29405903(+) AACCCA/GTTGGA 1 -- us2k10--------
    rs733989461,2
    C,F--29406029(+) ACCAAT/CGATAA 1 -- us2k13Minor allele frequency- C:0.16WA CSA 122
    rs1178584021,2
    C,F--29406242(+) TTATAT/ACAATA 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1462319121,2
    C--29406325(+) ATGAG-/AAAAAA 1 -- us2k10--------
    rs1882000161,2
    --29406404(+) ATTCTC/TTGAAA 1 -- us2k10--------
    rs1392943941,2
    --29406515(+) AGAATC/GCTTGG 1 -- us2k10--------
    rs733989471,2
    C,F--29406520(+) GCTTGG/CAGACT 1 -- us2k13Minor allele frequency- C:0.18WA CSA 122
    rs559699311,2
    C--29406542(+) AGAGCG/TTAAAG 1 -- us2k10--------
    rs1167861631,2
    C,F--29406555(+) AGACAA/TCAAAC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for OR10C1 ( 29407793 - 29408728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR10C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830624CNV Loss17160897

    Human Gene Mutation Database (HGMD): OR10C1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR10C1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR10C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR10C1           About GenesLikeMe

    Genetic Association Database (GAD): OR10C1
    Human Genome Epidemiology (HuGE) Navigator: OR10C1 (1 document)

    Export disorders for OR10C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PubMed id 19833159)1, 4 Thompson E.E....Ober C. (Hum. Immunol. 2010)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1 Volz A.... Ziegler A. (J. Biol. Chem. 2003)
    7. Different noses for different people. (PubMed id 12730696)2 Menashe I.... Gilad Y. (Nat. Genet. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 442194 HGNC: 8165 AceView: OR10C1 Ensembl:ENSG00000206474 euGenes: HUgn442194
    ECgene: OR10C1 Kegg: 442194 H-InvDB: OR10C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10C1 gene:
    Search GeneIP for patents involving OR10C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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