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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR10AD1 Gene

protein-coding   GIFtS: 45
GCID: GC12M048596

Olfactory Receptor, Family 10, Subfamily AD, Member 1

(Previous names: olfactory receptor, family 10, subfamily AD, member 1 pseudogene)
(Previous symbol: OR10AD1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 10, Subfamily AD, Member 11 2
OR10AD1P1 2 3
Olfactory Receptor, Family 10, Subfamily AD, Member 1 Pseudogene1 2
Olfactory Receptor OR12-12 3
OR12-12
Olfactory Receptor 10AD12

External Ids:    HGNC: 148191   Entrez Gene: 1212752   Ensembl: ENSG000001726407   UniProtKB: Q8NGE03   

Export aliases for OR10AD1 gene to outside databases

Previous GC identifers: GC12U900019 GC12M046883 GC12M046884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR10AD1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10AD1 Gene: 
OR10AD1 (olfactory receptor, family 10, subfamily AD, member 1) is a protein-coding gene. Diseases associated with OR10AD1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot: O10AD_HUMAN, Q8NGE0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10AD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR10AD1 gene promoter:
         Nkx3-1   HOXA9   HOXA9B   NF-1   C/EBPbeta   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10AD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR10AD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR10AD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

OR10AD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10AD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048596:  view genomic region     (about GC identifiers)

Start:
48,596,125 bp from pter      End:
48,597,075 bp from pter
Size:
951 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O10AD_HUMAN, Q8NGE0 (See protein sequence)
Recommended Name: Olfactory receptor 10AD1  
Size: 317 amino acids; 35698 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B9EGT9 Q6IFA8

Explore the universe of human proteins at neXtProt for OR10AD1: NX_Q8NGE0

Explore proteomics data for OR10AD1 at MOPED 

HORDE protein sequence for OR10AD1
OR10AD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR10AD1 Protein Expression

REFSEQ proteins: NP_001004134.1  
ENSEMBL proteins: 
 ENSP00000308689  
Reactome Protein details: Q8NGE0
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR10AD1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR10: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGE0

ProtoNet protein and cluster: Q8NGE0

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10AD_HUMAN, Q8NGE0
Similarity: Belongs to the G-protein coupled receptor 1 family


OR10AD1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O10AD_HUMAN, Q8NGE0
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR10AD1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR10AD1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR10AD1
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR10AD1):
    Olfactory transduction


OR10AD1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR10AD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR10AD1 (ENSP000003086894) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10P1ENSP000003080824STRING: ENSP00000308082
OR10W1ENSP000003785164STRING: ENSP00000378516
OR11G2ENSP000003499304STRING: ENSP00000349930
OR2A12ENSP000003861744STRING: ENSP00000386174
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR10AD1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for OR10AD1 (O10AD)

Search CenterWatch for drugs/clinical trials and news about OR10AD1 / O10AD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR10AD1 gene: 
NM_001004134.1  

Unigene Cluster for OR10AD1:

Olfactory receptor, family 10, subfamily AD, member 1
Hs.446790  [show with all ESTs]
Unigene Representative Sequence: BC136758
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000310248(uc001rrl.1)
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Additional mRNA sequence: 

BC136757.1 BC136758.1 

1 DOTS entry:

DT.95105650 

1 AceView cDNA sequence:

NM_001004134 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR10AD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR10AD1 Expression
About this image


See OR10AD1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.446790
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR10AD1 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr2861 , 5 olfactory receptor 2861, 5 84.35(n)1
80.51(a)1
  15 (54.23 cM)5
6295241  NM_001011779.11  NP_001011779.11 
 982266755 


ENSEMBL Gene Tree for OR10AD1 (if available)
TreeFam Gene Tree for OR10AD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR10AD1 gene
18/436 SIMAP similar genes for OR10AD1 using alignment to 1 protein entry:     O10AD_HUMAN(see all similar genes):
OR7A10    OR4K17    OR5A2    OR5V1    OR7A2P    OR10A5
OR1F12    OR2A12    OR2AK2    OR2T1    OR6P1    OR8S1
OR7D4    6M1-16    OLFR 42A    OR10A2    OR10A3    OR10A6

OR10AD1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/117 SNPs in OR10AD1 are shown (see all 117)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1174136361,2
C,F--48595710(+) AGTAAA/GATGAA 1 -- ds50011Minor allele frequency- G:0.01NA 120
rs750382851,2
C,F--48595716(+) ATGAAG/AAGCTG 1 -- ds50013Minor allele frequency- A:0.14NA CSA 124
rs1406540911,2
C--48595858(+) AAAAG-/AAACT 
GAGGAAAA
AAACT
1 -- ds50010--------
rs2018445601,2
C--48595863(-) TTCCTC/TANNNN 1 -- ds50010--------
rs1920305921,2
--48595897(+) TCTCCC/TGAGGA 1 -- ds50010--------
rs781379381,2
C,F--48596118(+) GCCTTC/TCTGCT 1 -- ds50013Minor allele frequency- T:0.08CSA NA EU 715
rs2007758351,2
--48596161(+) CCAAGC/TGCCCT 2 A syn10--------
rs111684591,2,4
C,F,H--48596241(+) GGTGTA/GCAGGA 2 H Y mis1 ese329Minor allele frequency- G:0.23EA NA NS WA CSA EU 8771
rs118303781,2,4
C,F,H--48596254(+) GAGAAA/CGGTTT 2 P syn1 ese3 trp327Minor allele frequency- C:0.07NA NS EA CSA EU 8356
rs2016113401,2
--48596327(+) GAAAGA/GTGACC 2 T I mis10--------

HapMap Linkage Disequilibrium report for OR10AD1 ( 48596125 - 48597075 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for OR10AD1:    About this table     
Variant IDTypeSubtypePubMed ID
esv33956CNV Loss17666407
esv34439CNV Gain17911159
nsv8971CNV Gain+Loss18304495
dgv509e1CNV Complex17122850
dgv510e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR10AD1:    About MalaCards
neuronitis    


OR10AD1 for disorders           About GeneDecksing


Export disorders for OR10AD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR10AD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR10AD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (2002)
  5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 121275 HGNC: 14819 AceView: OR10AD1 Ensembl:ENSG00000172640 euGenes: HUgn121275
ECgene: OR10AD1 Kegg: 121275 H-InvDB: OR10AD1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR10AD1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR10AD1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR10AD1 gene:
Search GeneIP for patents involving OR10AD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for OR10AD1
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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