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Aliases for OR10AD1 Gene

Aliases for OR10AD1 Gene

  • Olfactory Receptor Family 10 Subfamily AD Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-1 3 4
  • OR10AD1P 3 4
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 2
  • Olfactory Receptor 10AD1 3
  • OR12-1 3

External Ids for OR10AD1 Gene

Previous HGNC Symbols for OR10AD1 Gene

  • OR10AD1P

Previous GeneCards Identifiers for OR10AD1 Gene

  • GC12U900019
  • GC12M046883
  • GC12M046884
  • GC12M048596

Summaries for OR10AD1 Gene

Entrez Gene Summary for OR10AD1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AD1 Gene

OR10AD1 (Olfactory Receptor Family 10 Subfamily AD Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR10AD1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10AD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10AD1 Gene

Genomics for OR10AD1 Gene

Regulatory Elements for OR10AD1 Gene

Enhancers for OR10AD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F048022 0.6 FANTOM5 8.5 +184.1 184060 0.0 ZNF362 ZNF384 ZBTB8A TCF7L2 TRIM28 VDR ENSG00000205537 OR10AD1 COL2A1 LOC105369750
GH12F047804 1.5 FANTOM5 ENCODE 3.2 +387.9 387934 25.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC390314 KANSL2 CCNT1 RAPGEF3 ASB8 VDR SENP1 SLC48A1 LOC102725258 RPL37P19
GH12F048186 0.6 FANTOM5 7 +19.3 19304 0.4 CTCF PKNOX1 PBX2 IKZF1 FOS EBF1 ZNF641 LOC102725258 OR10AD1 RPL32P27 OR8S1 CCDC184 ENSG00000279875
GH12F047831 1.2 FANTOM5 ENCODE 2.7 +371.4 371355 5.0 HDGF TBL1XR1 NFXL1 RFX5 EGR1 GATA2 CREM EGR2 MCM3 CEBPB LOC102725258 RPL37P19 LOC390314 ENSG00000268069 OR10AD1 HDAC7 ENSG00000205537
GH12F047899 1.1 FANTOM5 ENCODE 1.1 +304.8 304837 3.1 ARID4B SIN3A ZNF48 RAD21 HSF1 SCRT2 ZNF143 FOS THAP11 CEBPB VDR CCNT1 SENP1 KANSL2 RPAP3 TMEM106C ZNF641 OR10AD1 GC12P047906 ENSG00000205537
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10AD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10AD1 Gene

Chromosome:
12
Start:
48,201,772 bp from pter
End:
48,205,682 bp from pter
Size:
3,911 bases
Orientation:
Minus strand

Genomic View for OR10AD1 Gene

Genes around OR10AD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AD1 Gene

Proteins for OR10AD1 Gene

  • Protein details for OR10AD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE0-O10AD_HUMAN
    Recommended name:
    Olfactory receptor 10AD1
    Protein Accession:
    Q8NGE0
    Secondary Accessions:
    • B9EGT9
    • Q6IFA8

    Protein attributes for OR10AD1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35698 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AD1 Gene

Post-translational modifications for OR10AD1 Gene

Other Protein References for OR10AD1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10AD1 Gene

Domains & Families for OR10AD1 Gene

Gene Families for OR10AD1 Gene

Protein Domains for OR10AD1 Gene

Suggested Antigen Peptide Sequences for OR10AD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGE0

UniProtKB/Swiss-Prot:

O10AD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AD1: view

Function for OR10AD1 Gene

Molecular function for OR10AD1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10AD1: view
genes like me logo Genes that share phenotypes with OR10AD1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AD1 Gene

Localization for OR10AD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10AD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10AD1: view

Pathways & Interactions for OR10AD1 Gene

genes like me logo Genes that share pathways with OR10AD1: view

Pathways by source for OR10AD1 Gene

1 KEGG pathway for OR10AD1 Gene

Gene Ontology (GO) - Biological Process for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for SIGNOR curated interactions for OR10AD1 Gene

Transcripts for OR10AD1 Gene

mRNA/cDNA for OR10AD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10AD1 Gene

Olfactory receptor, family 10, subfamily AD, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AD1 Gene

No ASD Table

Relevant External Links for OR10AD1 Gene

GeneLoc Exon Structure for
OR10AD1
ECgene alternative splicing isoforms for
OR10AD1

Expression for OR10AD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10AD1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10AD1 Gene

This gene is overexpressed in Pituitary (x4.5) and Testis (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR10AD1 Gene:

OR10AD1

SOURCE GeneReport for Unigene cluster for OR10AD1 Gene:

Hs.446790
genes like me logo Genes that share expression patterns with OR10AD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR10AD1 Gene

Orthologs for OR10AD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AD1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC486584 34
  • 88.06 (n)
OR10AD1 35
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10AD1 34
  • 87.2 (n)
-- 35
  • 83 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr287 34 35
  • 84.5 (n)
Or10ad1c 55 Olfr288 16 35
  • 79 (a)
Olfr286 35
  • 79 (a)
OneToMany
Or10ad1b-ps 55 Olfr286-ps1
  • chr15:98,226,677-98,227,628
Or10ad1-ps 55 Olfr287-ps1
  • chr15:98,207,446-98,208,382
Species where no ortholog for OR10AD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AD1 Gene

ENSEMBL:
Gene Tree for OR10AD1 (if available)
TreeFam:
Gene Tree for OR10AD1 (if available)

Paralogs for OR10AD1 Gene

(436) SIMAP similar genes for OR10AD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10AD1: view

No data available for Paralogs for OR10AD1 Gene

Variants for OR10AD1 Gene

Sequence variations from dbSNP and Humsavar for OR10AD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10783235 -- 48,203,724(+) GGAAA(A/G)GGCTG intron-variant, upstream-variant-2KB
rs111674296 -- 48,204,983(+) CCCAG(A/G)AAGGG intron-variant, upstream-variant-2KB
rs11168459 -- 48,202,458(+) GGTGT(A/G)CAGGA intron-variant, reference, missense
rs11168460 -- 48,203,582(+) ATTGC(A/G)TCTGC intron-variant, upstream-variant-2KB
rs112692896 -- 48,205,085(+) AAGTC(A/G)GTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10AD1 Gene

Variant ID Type Subtype PubMed ID
nsv8971 CNV gain+loss 18304495
esv3629429 CNV gain 21293372
esv34439 CNV gain 17911159
esv33956 CNV loss 17666407
esv2759898 CNV gain+loss 17122850

Variation tolerance for OR10AD1 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.27; 95.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10AD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10AD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10AD1 Gene

Disorders for OR10AD1 Gene

Relevant External Links for OR10AD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10AD1

No disorders were found for OR10AD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10AD1 Gene

Publications for OR10AD1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR10AD1 Gene

Sources for OR10AD1 Gene

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