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Aliases for OR10AD1 Gene

Aliases for OR10AD1 Gene

  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 2 3
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-1 3 4
  • OR10AD1P 3 4
  • Olfactory Receptor 10AD1 3
  • OR12-1 3

External Ids for OR10AD1 Gene

Previous Symbols for OR10AD1 Gene

  • OR10AD1P

Summaries for OR10AD1 Gene

Entrez Gene Summary for OR10AD1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AD1 Gene

OR10AD1 (Olfactory Receptor, Family 10, Subfamily AD, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR10AD1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10AD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10AD1 Gene

Genomics for OR10AD1 Gene

Genomic Location for OR10AD1 Gene

Start:
48,201,837 bp from pter
End:
48,205,320 bp from pter
Size:
3,484 bases
Orientation:
Minus strand

Genomic View for OR10AD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10AD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AD1 Gene

Regulatory Elements for OR10AD1 Gene

Proteins for OR10AD1 Gene

  • Protein details for OR10AD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE0-O10AD_HUMAN
    Recommended name:
    Olfactory receptor 10AD1
    Protein Accession:
    Q8NGE0
    Secondary Accessions:
    • B9EGT9
    • Q6IFA8

    Protein attributes for OR10AD1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35698 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AD1 Gene

Proteomics data for OR10AD1 Gene at MOPED

Post-translational modifications for OR10AD1 Gene

Other Protein References for OR10AD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10AD1 Gene

Domains for OR10AD1 Gene

Gene Families for OR10AD1 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10AD1 Gene

UniProtKB/Swiss-Prot:

O10AD_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGE0
genes like me logo Genes that share domains with OR10AD1: view

Function for OR10AD1 Gene

Molecular function for OR10AD1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10AD1 Gene

Localization for OR10AD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10AD1 Gene COMPARTMENTS Subcellular localization image for OR10AD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10AD1: view

Pathways for OR10AD1 Gene

genes like me logo Genes that share pathways with OR10AD1: view

Pathways by source for OR10AD1 Gene

1 KEGG pathway for OR10AD1 Gene

Interacting Proteins for OR10AD1 Gene

Gene Ontology (GO) - Biological Process for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AD1: view

Transcripts for OR10AD1 Gene

mRNA/cDNA for OR10AD1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10AD1 Gene

Olfactory receptor, family 10, subfamily AD, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AD1 Gene

No ASD Table

Relevant External Links for OR10AD1 Gene

GeneLoc Exon Structure for
OR10AD1
ECgene alternative splicing isoforms for
OR10AD1

Expression for OR10AD1 Gene

mRNA expression in normal human tissues for OR10AD1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10AD1 Gene

This gene is overexpressed in Pituitary (4.5) and Testis (4.1).

SOURCE GeneReport for Unigene cluster for OR10AD1 Gene Hs.446790

genes like me logo Genes that share expressions with OR10AD1: view

Orthologs for OR10AD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
OR10AD1 36
  • 87.2 (n)
  • 83.49 (a)
dog
(Canis familiaris)
Mammalia LOC486584 36
  • 88.06 (n)
  • 86.13 (a)
OR10AD1 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr286 16
Olfr286 37
  • 79 (a)
OneToMany
Olfr287 36
  • 84.5 (n)
  • 81.21 (a)
Olfr287 37
  • 79 (a)
OneToMany
Olfr288 37
  • 79 (a)
OneToMany
Species with no ortholog for OR10AD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AD1 Gene

ENSEMBL:
Gene Tree for OR10AD1 (if available)
TreeFam:
Gene Tree for OR10AD1 (if available)

Paralogs for OR10AD1 Gene

Selected SIMAP similar genes for OR10AD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10AD1: view

No data available for Paralogs for OR10AD1 Gene

Variants for OR10AD1 Gene

Sequence variations from dbSNP and Humsavar for OR10AD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1387258 -- 48,203,867(-) TGTTT(A/T)TATTT upstream-variant-2KB, intron-variant
rs7297824 -- 48,204,867(+) CTAGA(C/T)TCCCT upstream-variant-2KB, intron-variant
rs7315820 -- 48,205,155(+) TACTT(A/G)GTCCT upstream-variant-2KB, intron-variant
rs10783235 -- 48,203,724(+) GGAAA(A/G)GGCTG upstream-variant-2KB, intron-variant
rs10875767 -- 48,205,474(+) TTGAC(A/C)TCTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10AD1 Gene

Variant ID Type Subtype PubMed ID
dgv509e1 CNV Complex 17122850
nsv8971 CNV Gain+Loss 18304495
esv34439 CNV Gain 17911159
dgv510e1 CNV Complex 17122850
esv33956 CNV Loss 17666407

Relevant External Links for OR10AD1 Gene

HapMap Linkage Disequilibrium report
OR10AD1

Disorders for OR10AD1 Gene

No disorders were found for OR10AD1 Gene.

No data available for UniProtKB/Swiss-Prot for OR10AD1 Gene

Publications for OR10AD1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR10AD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate OR10AD1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for OR10AD1
    • Block miRNA regulation of OR10AD1 using miScript Target Protectors

    Sources for OR10AD1 Gene

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