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Aliases for OR10A7 Gene

Aliases for OR10A7 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 7 2 3 5
  • Olfactory Receptor, Family 10, Subfamily A, Member 7 2 3
  • Olfactory Receptor OR12-6 3 4
  • OR12-6 3

External Ids for OR10A7 Gene

Previous GeneCards Identifiers for OR10A7 Gene

  • GC12U990195
  • GC12P053902
  • GC12P053903
  • GC12P055614

Summaries for OR10A7 Gene

Entrez Gene Summary for OR10A7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A7 Gene

OR10A7 (Olfactory Receptor Family 10 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A3.

UniProtKB/Swiss-Prot for OR10A7 Gene

  • Odorant receptor.

Gene Wiki entry for OR10A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A7 Gene

Genomics for OR10A7 Gene

Regulatory Elements for OR10A7 Gene

Enhancers for OR10A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR10A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10A7 Gene

Chromosome:
12
Start:
55,221,025 bp from pter
End:
55,221,975 bp from pter
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10A7 Gene

Genes around OR10A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A7 Gene

Proteins for OR10A7 Gene

  • Protein details for OR10A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE5-O10A7_HUMAN
    Recommended name:
    Olfactory receptor 10A7
    Protein Accession:
    Q8NGE5
    Secondary Accessions:
    • Q6IFD5
    • Q96R19

    Protein attributes for OR10A7 Gene

    Size:
    316 amino acids
    Molecular mass:
    35695 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A7 Gene

Proteomics data for OR10A7 Gene at MOPED

Post-translational modifications for OR10A7 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A7 Gene

Domains & Families for OR10A7 Gene

Gene Families for OR10A7 Gene

Protein Domains for OR10A7 Gene

Suggested Antigen Peptide Sequences for OR10A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGE5

UniProtKB/Swiss-Prot:

O10A7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A7: view

Function for OR10A7 Gene

Molecular function for OR10A7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR10A7 Gene

genes like me logo Genes that share phenotypes with OR10A7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A7 Gene

Localization for OR10A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10A7 Gene COMPARTMENTS Subcellular localization image for OR10A7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR10A7: view

Pathways & Interactions for OR10A7 Gene

genes like me logo Genes that share pathways with OR10A7: view

Pathways by source for OR10A7 Gene

Interacting Proteins for OR10A7 Gene

Gene Ontology (GO) - Biological Process for OR10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A7: view

No data available for SIGNOR curated interactions for OR10A7 Gene

Drugs & Compounds for OR10A7 Gene

No Compound Related Data Available

Transcripts for OR10A7 Gene

mRNA/cDNA for OR10A7 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A7 Gene

No ASD Table

Relevant External Links for OR10A7 Gene

GeneLoc Exon Structure for
OR10A7
ECgene alternative splicing isoforms for
OR10A7

Expression for OR10A7 Gene

mRNA expression in normal human tissues for OR10A7 Gene

Protein differential expression in normal tissues from HIPED for OR10A7 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR10A7 Gene



SOURCE GeneReport for Unigene cluster for OR10A7 Gene Hs.554557

genes like me logo Genes that share expression patterns with OR10A7: view

Protein tissue co-expression partners for OR10A7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR10A7 Gene

Orthologs for OR10A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10A7 35
  • 88.78 (n)
  • 90.16 (a)
OR10A7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10A7 35
  • 89.31 (n)
  • 93.02 (a)
OR26G07 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC467020 35
  • 98.73 (n)
  • 97.78 (a)
mouse
(Mus musculus)
Mammalia Olfr1349 36
  • 49 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves OR10A4 35
  • 58.16 (n)
  • 54.61 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485112 35
  • 56.39 (n)
  • 51.3 (a)
Species with no ortholog for OR10A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A7 Gene

ENSEMBL:
Gene Tree for OR10A7 (if available)
TreeFam:
Gene Tree for OR10A7 (if available)

Paralogs for OR10A7 Gene

Paralogs for OR10A7 Gene

(448) SIMAP similar genes for OR10A7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10A7 Gene

genes like me logo Genes that share paralogs with OR10A7: view

Variants for OR10A7 Gene

Sequence variations from dbSNP and Humsavar for OR10A7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12578318 - 55,221,310(+) TTGTG(A/G)GCTGT reference, missense
rs17117146 -- 55,220,427(+) ATAAA(A/G)ATGTC upstream-variant-2KB
rs34372866 -- 55,221,918(+) TGAAA(-/G)GGGGC reference, frameshift-variant
rs111283936 -- 55,221,503(+) ACAGA(C/T)AGCTT reference, missense
rs112331116 -- 55,221,543(+) AATGC(C/T)GTGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR10A7 Gene

Variant ID Type Subtype PubMed ID
nsv899104 CNV Loss 21882294

Variation tolerance for OR10A7 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10A7 Gene

HapMap Linkage Disequilibrium report
OR10A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A7 Gene

Disorders for OR10A7 Gene

Relevant External Links for OR10A7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10A7

No disorders were found for OR10A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A7 Gene

Publications for OR10A7 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3

Products for OR10A7 Gene

Sources for OR10A7 Gene

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