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OR10A5 Gene

protein-coding   GIFtS: 50
GCID: GC11P006866

Olfactory Receptor, Family 10, Subfamily A, Member 5


(Previous symbol: OR10A1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily A, Member 51 2     OR11-4032 3
OR10A11 2 3 5     JCG62
Olfactory Receptor 10A12 3     Olfactory Receptor 10A52
Olfactory Receptor 11-4032 3     Olfactory Receptor OR11-852
Olfactory Receptor-Like Protein JCG62 3     Olfactory Receptor, Family 10, Subfamily A, Member 12
HP32 3     

External Ids:    HGNC: 151311   Entrez Gene: 1441242   Ensembl: ENSG000001663637   OMIM: 6084935   UniProtKB: Q9H2073   

Export aliases for OR10A5 gene to outside databases

Previous GC identifers: GC11U990582 GC11P006833 GC11P006823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10A5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10A5 Gene:
OR10A5 (olfactory receptor, family 10, subfamily A, member 5) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10C1.

UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207
Function: Odorant receptor (Potential). May be involved in taste perception

Gene Wiki entry for OR10A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10A5 gene promoter:
         HOXA9B   HOXA9   AML1a   Pax-6   LCR-F1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10A5 promoter sequence
   Search Chromatin IP Primers for OR10A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR10A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10A5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006866:  view genomic region     (about GC identifiers)

Start:
6,866,914 bp from pter      End:
6,867,864 bp from pter
Size:
951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207 (See protein sequence)
Recommended Name: Olfactory receptor 10A5  
Size: 317 amino acids; 35519 Da
Secondary accessions: O95223 Q52M66 Q96R21 Q96R22

Explore the universe of human proteins at neXtProt for OR10A5: NX_Q9H207

Explore proteomics data for OR10A5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR10A5

    See OR10A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_835462.1  
    ENSEMBL proteins: 
     ENSP00000299454   ENSP00000369159  
    Reactome Protein details: Q9H207

    OR10A5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H207

    ProtoNet protein and cluster: Q9H207

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10A5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10A5_HUMAN, Q9H207
    Function: Odorant receptor (Potential). May be involved in taste perception

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS9787077
         
    Find genes that share ontologies with OR10A5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR10A5:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Olfr713):
     nervous system 

    Find genes that share phenotypes with OR10A5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR10A5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10A5_HUMAN, Q9H207: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS9787077

    Find genes that share ontologies with OR10A5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10A5 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43
    4GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with OR10A5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OR10A5
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR10A5
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10A5):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10A5
    Interactions:

        Search GeneGlobe Interaction Network for OR10A5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR10A5 (ENSP000002994544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS9787077
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9787077

    Find genes that share ontologies with OR10A5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10A5 (O10A5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10A5 gene: 
    NM_178168.1  

    Unigene Cluster for OR10A5:

    Olfactory receptor, family 10, subfamily A, member 5
    Hs.447478
    Unigene Representative Sequence: BC093653
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299454 ENST00000379831(uc001met.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR10A5
      QuantiFast Probe-based Assays in human, mouse, rat OR10A5

    Additional mRNA sequence: 

    AF324499.1 BC093651.1 BC093653.1 

    1 DOTS entry:

    DT.95087054 

    2 AceView cDNA sequences:

    AF324499 NM_178168 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    OR10A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447478

    UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207
    Tissue specificity: Expressed in the tongue

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR10A5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7131 , 5 olfactory receptor 7131, 5 89.35(n)1
    92.41(a)1
      7 (56.10 cM)5
    2590361  NM_147034.11  NP_667245.11 
     1070361365 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343253.1(636431-637411)


    ENSEMBL Gene Tree for OR10A5 (if available)
    TreeFam Gene Tree for OR10A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10A5 gene
    OR10C12  OR10P12  OR10A32  OR10AG12  OR10A72  OR10A22  OR10A42  OR10A62  
    Selected SIMAP similar genes for OR10A5 using alignment to 2 protein entries:     O10A5_HUMAN (see all proteins) (see all similar genes):
    OR10A2    OR10A4    OR10A3    OR10A7    OR10A6    OR10J4
    OR10C1    OR10R3P    OR10J1    OR10P1    OR2D2    OR6C6
    OR10H2    OR10J5    OR2B8P    OR5B21    OR6C65    OR6C75

    Find genes that share paralogs with OR10A5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10A5 (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016359141,2
    C--6865029(+) TGTTC-/TTCTTC 1 -- us2k10--------
    rs71038671,2
    C,F,H--6865058(+) AGAGGC/TCACCA 1 -- us2k16Minor allele frequency- T:0.02NS EA CSA WA 540
    rs574616591,2
    C,F--6865138(+) CCATCG/AGATCT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs600581201,2
    C,F--6865231(+) TATAGT/CTCATT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1123782001,2
    F--6865388(+) CCTTTC/TGTATG 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1469633301,2
    --6865413(+) TCTTAA/GGTTTC 1 -- us2k10--------
    rs596458331,2
    C,F--6865421(+) TTCTTG/AGCAAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1434280961,2
    --6865437(+) AATCAC/TAGGTC 1 -- us2k10--------
    rs1475353801,2
    --6865439(+) TCATAC/GGTCTC 1 -- us2k10--------
    rs1394249701,2
    C--6865459(+) GCTTCC/TGTCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR10A5 ( 6866914 - 6867864 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR10A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv467701CNV Loss19166990
    nsv832060CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608493    OMIM disorders: --


    Find genes that share disorders with OR10A5           About GenesLikeMe

    Genetic Association Database (GAD): OR10A5

    Export disorders for OR10A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10A5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PubMed id 11416212)1, 2 Lane R.P.... Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. New GPCRs from a human lingual cDNA library. (PubMed id 11705801)1, 2 Gaudin J.-C.... Haertle T. (Chem. Senses 2001)
    5. Organization and evolution of olfactory receptor genes on human chromosome 11. (PubMed id 9787077)1, 2 Buettner J.A....Evans G.A. (Genomics 1998)
    6. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    7. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144124 HGNC: 15131 AceView: OR10A5 Ensembl:ENSG00000166363 euGenes: HUgn144124
    ECgene: OR10A5 Kegg: 144124 H-InvDB: OR10A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10A5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10A5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10A5 gene:
    Search GeneIP for patents involving OR10A5

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