OR10A5 Gene
protein-coding GIFtS: 48
GCID: GC11P006866
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|
olfactory receptor, family 10, subfamily A, member 5
(Previous symbol: OR10A1)
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Aliases
for OR10A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 10, Subfamily A, Member 51 2 | | Olfactory Receptor-Like Protein JCG62 3 | | OR10A11 2 3 | | HP32 3 | | OR11-4031 2 3 | | Olfactory Receptor 10A52 | | JCG61 2 | | Olfactory Receptor OR11-852 | | Olfactory Receptor 10A12 3 | | Olfactory Receptor, Family 10, Subfamily A, Member 12 | | Olfactory Receptor 11-4032 3 | | |
Export aliases for OR10A5 gene to outside databasesPrevious GC identifers: GC11U990582 GC11P006833 GC11P006823 |
Summaries
for OR10A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR10A5:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207Function: Odorant receptor (Potential). May be involved in taste perception
Gene Wiki entry for OR10A5
|
Genomic Views
for OR10A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR10A5 gene promoter:
HOXA9B HOXA9 AML1a Pax-6 LCR-F1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR10A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR10A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4OR10A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P006866: view genomic region
(about GC identifiers)
Start:
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6,866,914 bp from pter |
End:
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6,867,864 bp from pter |
Size:
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951 bases |
Orientation:
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plus strand |
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Proteins
for OR10A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207 (See
protein sequence)Recommended Name: Olfactory receptor 10A5 Size: 317 amino acids; 35519 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O95223 Q52M66 Q96R21 Q96R22Explore the universe of human proteins at neXtProt for OR10A5: NX_Q9H207
HORDE protein sequence for OR10A5
OR10A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_835462.1
ENSEMBL proteins: ENSP00000299454 ENSP00000369159 Reactome Protein details: Q9H207
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
OR10A5 for ontologies About GeneDecksing
OR10A5 Antibody Products:
Assay Products for OR10A5: |
Protein
Domains /
Families
for OR10A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR10A5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H207ProtoNet protein and cluster: Q9H207 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR10A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207Function: Odorant receptor (Potential). May be involved in taste perception
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OR10A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR10A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10A5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | 9787077 |
OR10A5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR10A5:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Olfr713):
OR10A5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OR10A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | GPCRs, Other | | | 4 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for OR10A5
4 
Reactome Pathways for OR10A5
1 
Kegg Pathway (Kegg details for OR10A5):
OR10A5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR10A5
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for OR10A5 (ENSP000002994544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007608 | sensory perception of smell |
NAS | 9787077 | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
NAS | 9787077 |
OR10A5 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR10A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR10A5
Search CenterWatch for drugs/clinical trials and news about OR10A5 / O10A5
|
Transcripts
for OR10A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR10A5 gene: NM_178168.1 Unigene Cluster for OR10A5: Olfactory receptor, family 10, subfamily A, member 5 Hs.447478 Unigene Representative Sequence: BC0936532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000299454 ENST00000379831(uc001met.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR10A5 (NM_178168) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR10A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR10A5 |
Additional cDNA sequence: AF324499.1 BC093651.1 BC093653.1 1 DOTS entry: DT.95087054 2 AceView cDNA sequences: NM_178168 AF324499
GeneLoc Exon Structure
|
Expression
for OR10A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR10A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR10A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR10A5
SOURCE GeneReport for Unigene cluster: Hs.447478
UniProtKB/Swiss-Prot: O10A5_HUMAN, Q9H207Tissue specificity: Expressed in the tongue
SABiosciences Custom PCR Arrays for OR10A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR10A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR10A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR10A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR10A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10A5 |
Orthologs
for OR10A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR10A5 gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for OR10A5 (if available)
TreeFam Gene Tree for OR10A5 (if available) |
Paralogs
for OR10A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR10A5 gene
- OR10C12 OR10P12 OR10A32 OR10AG12 OR10A22 OR10A62 OR10A42 OR10A72
18/459 SIMAP similar genes for OR10A5 using alignment to 2 protein entries: O10A5_HUMAN (see all proteins)
(see all similar genes):OR10A2 OR10A4 OR10A3 OR10A7 OR10A6 OR10J4
OR10C1 OR10R3P OR10J1 OR10P1 OR2D2 OR6C6
OR10H2 OR10J5 OR2B8P OR5B21 OR6C65 OR6C75
OR10A5 for paralogs About GeneDecksing
|
Genomic Variants
for OR10A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR10A5 ( 6866914 - 6867864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR10A5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR10A5 |
|
Disorders
/ Diseases
for OR10A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR10A5 for disorders About GeneDecksing
OMIM gene information: 608493
OMIM disorders: --
1  disease for OR10A5: About MalaCardsneuronitis
Export disorders for OR10A5 gene to outside databases
|
Publications
for OR10A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR10A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR10A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Genomic analysis of orthologous mouse and human olfactory receptor loci. (PubMed id 11416212)1, 2 Lane R.P.... Trask B.J. (2001)
- New GPCRs from a human lingual cDNA library. (PubMed id 11705801)1, 2 Gaudin J.-C.... Haertle T. (2001)
- Organization and evolution of olfactory receptor genes on human chromosome 11. (PubMed id 9787077)1, 2 Buettner J.A....Evans G.A. (1998)
- The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR10A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR10A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR10A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR10A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR10A5 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR10A5 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR10A5 gene:
Search GeneIP for patents involving OR10A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR10A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR10A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR10A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR10A5 | | | OriGene Protein Over-expression Lysate for OR10A5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR10A5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR10A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR10A5 | | OriGene Custom Protein Services for OR10A5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR10A5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR10A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR10A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR10A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR10A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR10A5 |
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 |  |  |  | |
| | | | Search Tocris compounds for OR10A5 |
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 | | | OR10A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10A5 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR10A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR10A5 |
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