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Aliases for OR10A4 Gene

Aliases for OR10A4 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 10, Subfamily A, Member 4 Pseudogene 2 3
  • Olfactory Receptor-Like Protein JCG5 3 4
  • OR10A4P 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 4 2
  • Olfactory Receptor OR11-87 3
  • HP2 Olfactory Receptor 3
  • JCG5 3
  • HP2 4

External Ids for OR10A4 Gene

Previous HGNC Symbols for OR10A4 Gene

  • OR10A4P

Previous GeneCards Identifiers for OR10A4 Gene

  • GC11U990583
  • GC11P006863
  • GC11P006854

Summaries for OR10A4 Gene

Entrez Gene Summary for OR10A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A4 Gene

OR10A4 (Olfactory Receptor Family 10 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A3.

UniProtKB/Swiss-Prot for OR10A4 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR10A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A4 Gene

Genomics for OR10A4 Gene

Regulatory Elements for OR10A4 Gene

Enhancers for OR10A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR10A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10A4 Gene

Chromosome:
11
Start:
6,876,621 bp from pter
End:
6,877,619 bp from pter
Size:
999 bases
Orientation:
Plus strand

Genomic View for OR10A4 Gene

Genes around OR10A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A4 Gene

Proteins for OR10A4 Gene

  • Protein details for OR10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H209-O10A4_HUMAN
    Recommended name:
    Olfactory receptor 10A4
    Protein Accession:
    Q9H209
    Secondary Accessions:
    • B2RNP5
    • B9EH36
    • Q96R20

    Protein attributes for OR10A4 Gene

    Size:
    315 amino acids
    Molecular mass:
    35117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A4 Gene

Proteomics data for OR10A4 Gene at MOPED

Post-translational modifications for OR10A4 Gene

Other Protein References for OR10A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A4 Gene

Domains & Families for OR10A4 Gene

Gene Families for OR10A4 Gene

Protein Domains for OR10A4 Gene

Suggested Antigen Peptide Sequences for OR10A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H209

UniProtKB/Swiss-Prot:

O10A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A4: view

Function for OR10A4 Gene

Molecular function for OR10A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.
genes like me logo Genes that share phenotypes with OR10A4: view

Animal Models for OR10A4 Gene

MGI Knock Outs for OR10A4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A4 Gene

Localization for OR10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10A4 Gene COMPARTMENTS Subcellular localization image for OR10A4 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for OR10A4 Gene

Pathways & Interactions for OR10A4 Gene

genes like me logo Genes that share pathways with OR10A4: view

Pathways by source for OR10A4 Gene

1 BioSystems pathway for OR10A4 Gene
1 KEGG pathway for OR10A4 Gene

Interacting Proteins for OR10A4 Gene

Gene Ontology (GO) - Biological Process for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A4: view

No data available for SIGNOR curated interactions for OR10A4 Gene

Drugs & Compounds for OR10A4 Gene

No Compound Related Data Available

Transcripts for OR10A4 Gene

mRNA/cDNA for OR10A4 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A4 Gene

No ASD Table

Relevant External Links for OR10A4 Gene

GeneLoc Exon Structure for
OR10A4
ECgene alternative splicing isoforms for
OR10A4

Expression for OR10A4 Gene

mRNA expression in normal human tissues for OR10A4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A4 Gene

This gene is overexpressed in Testis (x14.5) and Brain - Putamen (basal ganglia) (x5.0).

SOURCE GeneReport for Unigene cluster for OR10A4 Gene Hs.448685

mRNA Expression by UniProt/SwissProt for OR10A4 Gene

Q9H209-O10A4_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR10A4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OR10A4 Gene

Orthologs for OR10A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10A4 35
  • 88.47 (n)
  • 89.52 (a)
OR10A4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10A4 35
  • 88.78 (n)
  • 89.52 (a)
-- 36
  • 68 (a)
OneToMany
OR28A08 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr17 35
  • 86.24 (n)
  • 88.25 (a)
Olfr17 16
Olfr17 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr231 35
  • 85.29 (n)
  • 86.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
Species with no ortholog for OR10A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A4 Gene

ENSEMBL:
Gene Tree for OR10A4 (if available)
TreeFam:
Gene Tree for OR10A4 (if available)

Paralogs for OR10A4 Gene

Paralogs for OR10A4 Gene

(454) SIMAP similar genes for OR10A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10A4: view

Variants for OR10A4 Gene

Sequence variations from dbSNP and Humsavar for OR10A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_024124 -
VAR_034280 -
VAR_034281 -
VAR_060023 -

Structural Variations from Database of Genomic Variants (DGV) for OR10A4 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897
nsv825756 CNV Loss 20364138

Variation tolerance for OR10A4 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.13; 96.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10A4 Gene

HapMap Linkage Disequilibrium report
OR10A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A4 Gene

Disorders for OR10A4 Gene

Relevant External Links for OR10A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10A4

No disorders were found for OR10A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A4 Gene

Publications for OR10A4 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin J.-C. … Haertle T. (Chem. Senses 2001) 3
  5. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane R.P. … Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3

Products for OR10A4 Gene

Sources for OR10A4 Gene

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