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Aliases for OR10A4 Gene

Aliases for OR10A4 Gene

  • Olfactory Receptor, Family 10, Subfamily A, Member 4 2 3
  • Olfactory Receptor, Family 10, Subfamily A, Member 4 Pseudogene 2 3
  • Olfactory Receptor-Like Protein JCG5 3 4
  • OR10A4P 3 4
  • Olfactory Receptor OR11-87 3
  • Olfactory Receptor 10A4 3
  • HP2 Olfactory Receptor 3
  • JCG5 3
  • HP2 4

External Ids for OR10A4 Gene

Previous Symbols for OR10A4 Gene

  • OR10A4P

Summaries for OR10A4 Gene

Entrez Gene Summary for OR10A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A4 Gene

OR10A4 (Olfactory Receptor, Family 10, Subfamily A, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A3.

UniProtKB/Swiss-Prot for OR10A4 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR10A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A4 Gene

Genomics for OR10A4 Gene

Genomic Location for OR10A4 Gene

Start:
6,876,625 bp from pter
End:
6,877,619 bp from pter
Size:
995 bases
Orientation:
Plus strand

Genomic View for OR10A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A4 Gene

Regulatory Elements for OR10A4 Gene

Proteins for OR10A4 Gene

  • Protein details for OR10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H209-O10A4_HUMAN
    Recommended name:
    Olfactory receptor 10A4
    Protein Accession:
    Q9H209
    Secondary Accessions:
    • B2RNP5
    • B9EH36
    • Q96R20

    Protein attributes for OR10A4 Gene

    Size:
    315 amino acids
    Molecular mass:
    35117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A4 Gene

Proteomics data for OR10A4 Gene at MOPED

Post-translational modifications for OR10A4 Gene

Other Protein References for OR10A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10A4 Gene

Domains for OR10A4 Gene

Gene Families for OR10A4 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10A4 Gene

UniProtKB/Swiss-Prot:

O10A4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9H209
genes like me logo Genes that share domains with OR10A4: view

Function for OR10A4 Gene

Molecular function for OR10A4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10A4: view
genes like me logo Genes that share phenotypes with OR10A4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10A4 Gene

Localization for OR10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10A4 Gene COMPARTMENTS Subcellular localization image for OR10A4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A4: view

Pathways for OR10A4 Gene

genes like me logo Genes that share pathways with OR10A4: view

Pathways by source for OR10A4 Gene

1 BioSystems pathway for OR10A4 Gene
1 KEGG pathway for OR10A4 Gene

Interacting Proteins for OR10A4 Gene

Gene Ontology (GO) - Biological Process for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007411 axon guidance IEA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A4: view

Transcripts for OR10A4 Gene

mRNA/cDNA for OR10A4 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A4 Gene

No ASD Table

Relevant External Links for OR10A4 Gene

GeneLoc Exon Structure for
OR10A4
ECgene alternative splicing isoforms for
OR10A4

Expression for OR10A4 Gene

mRNA expression in normal human tissues for OR10A4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A4 Gene

This gene is overexpressed in Testis (14.5) and Brain - Putamen (basal ganglia) (5.0).

SOURCE GeneReport for Unigene cluster for OR10A4 Gene Hs.448685

mRNA Expression by UniProt/SwissProt for OR10A4 Gene

Q9H209-O10A4_HUMAN
Tissue specificity: Expressed in the tongue
genes like me logo Genes that share expressions with OR10A4: view

Orthologs for OR10A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10A4 36
  • 88.47 (n)
  • 89.52 (a)
OR10A4 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 68 (a)
OneToMany
OR10A4 36
  • 88.78 (n)
  • 89.52 (a)
OR28A08 37
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr17 36
  • 86.24 (n)
  • 88.25 (a)
Olfr17 16
Olfr17 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr231 36
  • 85.29 (n)
  • 86.98 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 50 (a)
OneToMany
Species with no ortholog for OR10A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A4 Gene

ENSEMBL:
Gene Tree for OR10A4 (if available)
TreeFam:
Gene Tree for OR10A4 (if available)

Paralogs for OR10A4 Gene

Paralogs for OR10A4 Gene

Selected SIMAP similar genes for OR10A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10A4: view

Variants for OR10A4 Gene

Sequence variations from dbSNP and Humsavar for OR10A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2595453 - 6,877,264(+) TGTCC(C/T)ATTCA missense, reference
rs2741757 -- 6,876,020(-) GTCAG(G/T)GTGGC upstream-variant-2KB
rs2741758 -- 6,874,816(-) CTTCT(C/T)TTATG upstream-variant-2KB
rs7102808 -- 6,877,527(+) GCTCA(A/C)GGAAT reference, synonymous-codon
rs7929584 -- 6,874,665(+) aatgg(A/G)tataa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10A4 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897
nsv825756 CNV Loss 20364138

Relevant External Links for OR10A4 Gene

HapMap Linkage Disequilibrium report
OR10A4

Disorders for OR10A4 Gene

No disorders were found for OR10A4 Gene.

No data available for UniProtKB/Swiss-Prot for OR10A4 Gene

Publications for OR10A4 Gene

  1. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane R.P. … Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin J.-C. … Haertle T. (Chem. Senses 2001) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR10A4 Gene

  • antibodies-online peptides for OR10A4
  • antibodies-online antibodies for OR10A4
  • antibodies-online kits for OR10A4

Sources for OR10A4 Gene

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