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Aliases for OR10A3 Gene

Aliases for OR10A3 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 3 2 3 5
  • Olfactory Receptor OR11-97 3 4
  • HTPCRX12 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 3 2
  • Olfactory Receptor 10A3 3
  • HSHTPCRX12 3

External Ids for OR10A3 Gene

Previous GeneCards Identifiers for OR10A3 Gene

  • GC11M008760
  • GC11U900024
  • GC11M007919
  • GC11M007924
  • GC11M007916
  • GC11M007960
  • GC11M007942
  • GC11M007943
  • GC11M007944
  • GC11M007946
  • GC11M007947

Summaries for OR10A3 Gene

Entrez Gene Summary for OR10A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A3 Gene

OR10A3 (Olfactory Receptor Family 10 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A6.

UniProtKB/Swiss-Prot for OR10A3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A3 Gene

Genomics for OR10A3 Gene

Regulatory Elements for OR10A3 Gene

Enhancers for OR10A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G007962 1.6 Ensembl ENCODE dbSUPER 11 -27.1 -27139 8.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 EIF3F TUB TMEM9B-AS1 NLRP10 OR10A3 AKIP1 CASC23 GC11M007966
GH11G007890 1.3 FANTOM5 Ensembl ENCODE 9.5 +46.5 46498 5.8 ELF3 TBP CTCF PKNOX1 RAD21 RFX5 ZNF143 SMC3 IKZF2 ZNF654 OR10A3 NLRP14 OR10A6 PIR41542 PIR32361
GH11G007904 0.9 Ensembl ENCODE 11.1 +33.0 33010 4.4 CTCF ZNF680 CEBPB KLF4 RAD21 ATF2 POLR2A ATF3 GLIS1 SCRT2 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F LOC283299
GH11G007898 0.6 ENCODE 11 +40.1 40116 1.5 PKNOX1 CEBPB JUNB EP300 GATA3 STAT3 RCOR1 TCF7L2 OR10A3 NLRP10 PIR32361 PIR41542
GH11G007900 0.6 ENCODE 11 +38.0 38014 2.4 CTBP1 GATA3 CEBPB FOS HNF4A DPF2 NLRP10 OR10A6 OR10A3 CASC23 TUB OVCH2 PIR32361 PIR62490
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10A3 Gene

Chromosome:
11
Start:
7,938,534 bp from pter
End:
7,939,594 bp from pter
Size:
1,061 bases
Orientation:
Minus strand

Genomic View for OR10A3 Gene

Genes around OR10A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A3 Gene

Proteins for OR10A3 Gene

  • Protein details for OR10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58181-O10A3_HUMAN
    Recommended name:
    Olfactory receptor 10A3
    Protein Accession:
    P58181
    Secondary Accessions:
    • B9EH39
    • Q6IF58
    • Q96R11

    Protein attributes for OR10A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    35535 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A3 Gene

Post-translational modifications for OR10A3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A3 Gene

Domains & Families for OR10A3 Gene

Gene Families for OR10A3 Gene

Protein Domains for OR10A3 Gene

Suggested Antigen Peptide Sequences for OR10A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58181

UniProtKB/Swiss-Prot:

O10A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A3: view

Function for OR10A3 Gene

Molecular function for OR10A3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR10A3: view
genes like me logo Genes that share phenotypes with OR10A3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A3 Gene

Localization for OR10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A3: view

Pathways & Interactions for OR10A3 Gene

genes like me logo Genes that share pathways with OR10A3: view

Pathways by source for OR10A3 Gene

Interacting Proteins for OR10A3 Gene

Gene Ontology (GO) - Biological Process for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,NAS 1370859
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A3: view

No data available for SIGNOR curated interactions for OR10A3 Gene

Transcripts for OR10A3 Gene

mRNA/cDNA for OR10A3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10A3 Gene

Olfactory receptor, family 10, subfamily A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A3 Gene

No ASD Table

Relevant External Links for OR10A3 Gene

GeneLoc Exon Structure for
OR10A3
ECgene alternative splicing isoforms for
OR10A3

Expression for OR10A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.5), Skin - Not Sun Exposed (Suprapubic) (x11.5), and Bladder (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of OR10A3 Gene:

OR10A3

SOURCE GeneReport for Unigene cluster for OR10A3 Gene:

Hs.381322
genes like me logo Genes that share expression patterns with OR10A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A3 Gene

Orthologs for OR10A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466434 34
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
OR10A6 34
  • 86.2 (n)
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr282 34
  • 82.8 (n)
mouse
(Mus musculus)
Mammalia Or10a3 55 Olfr518 34 16 35
  • 82.42 (n)
Or10a3b 55 Olfr516 35
  • 80 (a)
ManyToMany
Olfr517 35
  • 77 (a)
ManyToMany
Or10a47 55 Olfr512 35
  • 76 (a)
ManyToMany
Or10a50 55 Olfr519 35
  • 76 (a)
ManyToMany
Or10a48 55 Olfr514 35
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
OneToMany
Species where no ortholog for OR10A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A3 Gene

ENSEMBL:
Gene Tree for OR10A3 (if available)
TreeFam:
Gene Tree for OR10A3 (if available)

Paralogs for OR10A3 Gene

Paralogs for OR10A3 Gene

(449) SIMAP similar genes for OR10A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10A3 Gene

genes like me logo Genes that share paralogs with OR10A3: view

Variants for OR10A3 Gene

Sequence variations from dbSNP and Humsavar for OR10A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000050091 -- 7,938,725(+) TGAGT(A/G)GCCAG reference, missense
rs1000153609 -- 7,941,496(+) TAAGA(A/T)TTGAT upstream-variant-2KB
rs1001567605 -- 7,938,754(+) TCATA(C/T)TGGCT reference, missense
rs1002014211 -- 7,939,838(+) TTCCC(A/C/G)TTTAA upstream-variant-2KB
rs1003255613 -- 7,939,984(+) TGGAA(C/T)TTGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10A3 Gene

Variant ID Type Subtype PubMed ID
esv3625306 CNV gain 21293372
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OR10A3 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A3 Gene

Disorders for OR10A3 Gene

Relevant External Links for OR10A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10A3

No disorders were found for OR10A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A3 Gene

Publications for OR10A3 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  5. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (PMID: 23042114) Hirota T. … Tamari M. (Nat. Genet. 2012) 3 64

Products for OR10A3 Gene

Sources for OR10A3 Gene

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