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Aliases for OR10A3 Gene

Aliases for OR10A3 Gene

  • Olfactory Receptor, Family 10, Subfamily A, Member 3 2 3
  • Olfactory Receptor OR11-97 3 4
  • HTPCRX12 3 4
  • Olfactory Receptor 10A3 3
  • HSHTPCRX12 3

External Ids for OR10A3 Gene

Summaries for OR10A3 Gene

Entrez Gene Summary for OR10A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A3 Gene

OR10A3 (Olfactory Receptor, Family 10, Subfamily A, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10AG1.

UniProtKB/Swiss-Prot for OR10A3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A3 Gene

Genomics for OR10A3 Gene

Genomic Location for OR10A3 Gene

Start:
7,938,534 bp from pter
End:
7,939,594 bp from pter
Size:
1,061 bases
Orientation:
Minus strand

Genomic View for OR10A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A3 Gene

Regulatory Elements for OR10A3 Gene

Proteins for OR10A3 Gene

  • Protein details for OR10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58181-O10A3_HUMAN
    Recommended name:
    Olfactory receptor 10A3
    Protein Accession:
    P58181
    Secondary Accessions:
    • B9EH39
    • Q6IF58
    • Q96R11

    Protein attributes for OR10A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    35535 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A3 Gene

Proteomics data for OR10A3 Gene at MOPED

Post-translational modifications for OR10A3 Gene

Other Protein References for OR10A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10A3 Gene

Domains for OR10A3 Gene

Gene Families for OR10A3 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10A3 Gene

UniProtKB/Swiss-Prot:

O10A3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P58181
genes like me logo Genes that share domains with OR10A3: view

Function for OR10A3 Gene

Molecular function for OR10A3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR10A3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10A3 Gene

Localization for OR10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10A3 Gene COMPARTMENTS Subcellular localization image for OR10A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A3: view

Pathways for OR10A3 Gene

genes like me logo Genes that share pathways with OR10A3: view

Pathways by source for OR10A3 Gene

Interacting Proteins for OR10A3 Gene

Gene Ontology (GO) - Biological Process for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 1370859
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 1370859
genes like me logo Genes that share ontologies with OR10A3: view

Transcripts for OR10A3 Gene

mRNA/cDNA for OR10A3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10A3 Gene

Olfactory receptor, family 10, subfamily A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A3 Gene

No ASD Table

Relevant External Links for OR10A3 Gene

GeneLoc Exon Structure for
OR10A3
ECgene alternative splicing isoforms for
OR10A3

Expression for OR10A3 Gene

mRNA expression in normal human tissues for OR10A3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (13.5), Skin - Not Sun Exposed (Suprapubic) (11.5), and Bladder (6.7).

SOURCE GeneReport for Unigene cluster for OR10A3 Gene Hs.381322

genes like me logo Genes that share expressions with OR10A3: view

Orthologs for OR10A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466434 36
  • 99.03 (n)
  • 97.45 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
OR10A6 36
  • 86.2 (n)
  • 85.03 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr512 37
  • 76 (a)
ManyToMany
Olfr514 37
  • 75 (a)
ManyToMany
Olfr516 37
  • 80 (a)
ManyToMany
Olfr517 37
  • 77 (a)
ManyToMany
Olfr518 36
  • 82.42 (n)
  • 83.28 (a)
Olfr518 16
Olfr518 37
  • 78 (a)
ManyToMany
Olfr519 37
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr282 36
  • 82.8 (n)
  • 83.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
OneToMany
Species with no ortholog for OR10A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A3 Gene

ENSEMBL:
Gene Tree for OR10A3 (if available)
TreeFam:
Gene Tree for OR10A3 (if available)

Paralogs for OR10A3 Gene

Paralogs for OR10A3 Gene

Selected SIMAP similar genes for OR10A3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10A3 Gene

genes like me logo Genes that share paralogs with OR10A3: view

Variants for OR10A3 Gene

Sequence variations from dbSNP and Humsavar for OR10A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1397599 -- 7,941,261(+) AAATT(A/T)CTGCC upstream-variant-2KB
rs1397600 -- 7,941,520(+) AAACC(A/G)TCTAT upstream-variant-2KB
rs1511002 -- 7,938,405(+) ATATG(C/T)ATCTA downstream-variant-500B
rs4758259 -- 7,939,583(+) TAATC(C/T)CATAG upstream-variant-2KB
rs4758260 -- 7,939,923(+) ATTCT(G/T)CAAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10A3 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Relevant External Links for OR10A3 Gene

HapMap Linkage Disequilibrium report
OR10A3

Disorders for OR10A3 Gene

No disorders were found for OR10A3 Gene.

No data available for UniProtKB/Swiss-Prot for OR10A3 Gene

Publications for OR10A3 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  5. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (PMID: 23042114) Hirota T. … Tamari M. (Nat. Genet. 2012) 3

Products for OR10A3 Gene

Sources for OR10A3 Gene

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