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OR10A2 Gene

protein-coding   GIFtS: 46
GCID: GC11P006890

Olfactory Receptor, Family 10, Subfamily A, Member 2


(Previous symbol: OR10A2P)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily A, Member 21 2     HP4 Olfactory Receptor2
OR10A2P1 2 3     Olfactory Receptor 10A22
Olfactory Receptor OR11-862 3     Olfactory Receptor OR11-82 Pseudogene2
OR11-822     Olfactory Receptor, Family 10, Subfamily A, Member 2 Pseudogene2
OR11-862     HP43
OST3632     

External Ids:    HGNC: 81611   Entrez Gene: 3412762   Ensembl: ENSG000001707907   UniProtKB: Q9H2083   

Export aliases for OR10A2 gene to outside databases

Previous GC identifers: GC11P006850 GC11P006841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10A2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10A2 Gene:
OR10A2 (olfactory receptor, family 10, subfamily A, member 2) is a protein-coding gene. Diseases associated with OR10A2 include vasomotor rhinitis, and rhinitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10C1.

UniProtKB/Swiss-Prot: O10A2_HUMAN, Q9H208
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10A2 gene promoter:
         Nkx3-1   Max1   GATA-3   Nkx3-1 v1   GATA-1   GATA-2   FAC1   TGIF   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10A2 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR10A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006890:  view genomic region     (about GC identifiers)

Start:
6,890,986 bp from pter      End:
6,891,894 bp from pter
Size:
909 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O10A2_HUMAN, Q9H208 (See protein sequence)
Recommended Name: Olfactory receptor 10A2  
Size: 303 amino acids; 33817 Da
Sequence caution: Sequence=AAG45207.1; Type=Erroneous initiation;
Secondary accessions: B2RNL9 Q6IFG9

Explore the universe of human proteins at neXtProt for OR10A2: NX_Q9H208

Explore proteomics data for OR10A2 at MOPED

HORDE protein sequence for OR10A2

See OR10A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004460.1  
ENSEMBL proteins: 
 ENSP00000303862  
Reactome Protein details: Q9H208

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR10: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9H208

ProtoNet protein and cluster: Q9H208

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10A2_HUMAN, Q9H208
Similarity: Belongs to the G-protein coupled receptor 1 family


OR10A2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O10A2_HUMAN, Q9H208
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR10A2 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Olfr714):
 nervous system 

OR10A2 for phenotypes           About GeneDecksing

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O10A2_HUMAN, Q9H208: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR10A2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR10A2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3GPCRs, Other
GPCRs, Other

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR10A2
    GPCRs, Other

1 Reactome Pathway for OR10A2
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR10A2):
    Olfactory transduction


OR10A2 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10A2
Interactions:

    Search GeneGlobe Interaction Network for OR10A2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR10A2 (ENSP000003038624) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
GNALENSP000003340514STRING: ENSP00000334051
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR10A2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OR10A2 (O10A2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR10A2 gene: 
NM_001004460.1  

Unigene Cluster for OR10A2:

Olfactory receptor, family 10, subfamily A, member 2
Hs.371762
Unigene Representative Sequence: BC136955
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000307322(uc001meu.1)
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Additional mRNA sequence: BC136955.1 

1 AceView cDNA sequence:

NM_001004460 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR10A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGAACCCCA
OR10A2 Expression
About this image

OR10A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR10A2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.371762
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OR10A2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr7141 , 5 olfactory receptor 7141, 5 88.08(n)1
89.74(a)1
  7 (56.10 cM)5
2590351  NM_147033.21  NP_667244.21 
 1070738305 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
47(a)
many ↔ many
10(332748-334266) ENSGALG00000002547
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
46(a)
1 → many
GL343253.1(636431-637411)


ENSEMBL Gene Tree for OR10A2 (if available)
TreeFam Gene Tree for OR10A2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR10A2 gene
OR10C12  OR10P12  OR10A32  OR10AG12  OR10A72  OR10A42  OR10A62  OR10A52  
Selected SIMAP similar genes for OR10A2 using alignment to 1 protein entry:     O10A2_HUMAN(see all similar genes):
OR10A5    OR10A4    OR10A7    OR10A3    OR10A6    OR10J4
OR10C1    OR6C6    OR10J1    OR10P1    OR10R3P    OR2C3
OR2D2    OR2K2    OR6X1    OR8B3    OR6C74    OR10H2

OR10A2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR10A2 (see all 131)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs594838141,2
C--6889094(+) TCCCAC/TCTCAG 1 -- us2k13Minor allele frequency- T:0.43NA CSA 123
rs1457841851,2
--6889131(+) ATATGC/TCACCA 1 -- us2k10--------
rs1489283981,2
--6889177(+) GGTTTC/TGCCAC 1 -- us2k10--------
rs1132213251,2
C--6889261(+) CAGGCA/GTCAGC 1 -- us2k15Minor allele frequency- G:0.29NA CSA WA EA 361
rs729209991,2
C--6889371(+) GAAACC/TGAGCT 1 -- us2k15Minor allele frequency- T:0.29NA CSA WA EA 361
rs583633181,2
C,F--6889589(+) TGTGCG/ATAAAG 1 -- us2k12Minor allele frequency- A:0.09WA 120
rs729210011,2
C--6889648(+) TACAGC/ATTTTG 1 -- us2k15Minor allele frequency- A:0.29NA CSA WA EA 361
rs1436715811,2
--6889756(+) CTCCTC/TATCTA 1 -- us2k10--------
rs772406381,2
C,F--6889862(+) GTCAGT/CTCTGG 1 -- us2k13Minor allele frequency- C:0.12WA NA EA 358
rs1451936551,2
C--6889909(+) ATTAA-/TTTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR10A2 ( 6890986 - 6891894 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR10A2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2664185CNV Deletion23128226
nsv832061CNV Loss17160897
nsv467701CNV Loss19166990

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for OR10A2:    About MalaCards
vasomotor rhinitis    rhinitis    neuronitis


OR10A2 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR10A2
Human Genome Epidemiology (HuGE) Navigator: OR10A2 (1 document)

Export disorders for OR10A2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR10A2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR10A2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. (PubMed id 18446592)1, 4 Bernstein J.A....Nebert D.W. (J Asthma 2008)
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
  3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
  5. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PubMed id 11416212)1, 2 Lane R.P.... Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
  6. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
  7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 341276 HGNC: 8161 AceView: OR10A2 Ensembl:ENSG00000170790 euGenes: HUgn341276
ECgene: OR10A2 Kegg: 341276 H-InvDB: OR10A2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR10A2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR10A2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR10A2 gene:
Search GeneIP for patents involving OR10A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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