Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPTC Gene

protein-coding   GIFtS: 54
GCID: GC01P203464

Opticin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
opticin1 2
oculoglycan1 2
OPT2 3
Oculoglycan3

External Ids:    HGNC: 81581   Entrez Gene: 262542   Ensembl: ENSG000001887707   OMIM: 6051275   UniProtKB: Q9UBM43   

Export aliases for OPTC gene to outside databases

Previous GC identifers: GC01M201246 GC01M198990 GC01P9D0052 GC00P9S0052 GC01P200194 GC01P201729 GC01P174628


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OPTC Gene:
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are
typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous
of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver.
Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The
opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related
macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). (provided by RefSeq, Jul
2008)

GeneCards Summary for OPTC Gene: 
OPTC (opticin) is a protein-coding gene. Diseases associated with OPTC include asthenopia, and vitreous detachment. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OGN.

UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
Function: Binds collagen fibrils (By similarity)

Gene Wiki entry for OPTC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPTC gene promoter:
         Oct-B1   GR   oct-B3   oct-B2   MEF-2   MEF-2A   IRF-2   POU2F1   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPTC promoter sequence
   Search SABiosciences Chromatin IP Primers for OPTC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

OPTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPTC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203464:  view genomic region     (about GC identifiers)

Start:
203,463,271 bp from pter      End:
203,478,077 bp from pter
Size:
14,807 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4 (See protein sequence)
Recommended Name: Opticin precursor  
Size: 332 amino acids; 37261 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q5T2G4

Explore the universe of human proteins at neXtProt for OPTC: NX_Q9UBM4

Explore proteomics data for OPTC at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBM4

  • OPTC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OPTC Protein Expression
    REFSEQ proteins: NP_055174.1  
    ENSEMBL proteins: 
     ENSP00000356191   ENSP00000399491  

    Human Recombinant Protein Products for OPTC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OPTC
    OriGene Protein Over-expression Lysate for OPTC
    OriGene MassSpec for OPTC 
    OriGene Custom Protein Services for OPTC
    GenScript Custom Purified and Recombinant Proteins Services for OPTC
    Novus Biologicals OPTC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OPTC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    OPTC for ontologies           About GeneDecksing



    OPTC Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for OPTC (Opticin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OPTC
    GenScript Custom Superior Antibodies Services for OPTC
    Novus Biologicals OPTC Antibodies
    Abcam antibodies for OPTC
    Cloud-Clone Corp. Antibodies for OPTC 
    Search ThermoFisher Antibodies for OPTC
    LSBio Antibodies in human, mouse, rat for OPTC 

    Assay Products for OPTC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OPTC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OPTC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OPTC 
    Cloud-Clone Corp. CLIAs for OPTC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q9UBM4

    ProtoNet protein and cluster: Q9UBM4

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    OPTC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPT_HUMAN, Q9UBM4
    Function: Binds collagen fibrils (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10636917
    GO:0005515protein binding ----
         
    OPTC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OPTC:
     Decreased Hepatitis C virus re 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Optc):
     cardiovascular system  vision/eye 

    OPTC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Optctm1.1Pnb for OPTC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OPTC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OPTC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPTC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPTC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPTC
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OPTC:
    hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidOPTC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OPTC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPTC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OPTC
    Sirion Biotech Customized adenovirus for overexpression of OPTC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OPTC (see all 10)
    OriGene ORF clones in mouse, rat for OPTC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OPTC (NM_014359)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPTC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPTC
    Sirion Biotech Customized lentivirus for stable overexpression of OPTC 
                         Customized lentivirus expression plasmids for stable overexpression of OPTC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OPTC
    Search LifeMap BioReagents cell lines for OPTC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPTC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OPTC

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for OPTC (Q9UBM43 ENSP000003561914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OPTC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OPTC (OPT)

    1 Novoseek inferred chemical compound relationship for OPTC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 16.4 1 11814684 (1)

    Search CenterWatch for drugs/clinical trials and news about OPTC / OPT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OPTC gene: 
    NM_014359.3  

    Unigene Cluster for OPTC:

    Opticin
    Hs.632468  [show with all ESTs]
    Unigene Representative Sequence: NM_014359
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367222(uc001gzu.1) ENST00000448911
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPTC
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate OPTC:
    hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidOPTC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OPTC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPTC
    Clone
    Products:
         
    OriGene clones in human, mouse for OPTC (see all 10)
    OriGene ORF clones in mouse, rat for OPTC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OPTC (NM_014359)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPTC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPTC
    Sirion Biotech Customized lentivirus for stable overexpression of OPTC 
                         Customized lentivirus expression plasmids for stable overexpression of OPTC 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OPTC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPTC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPTC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPTC

    Additional mRNA sequence: 

    AF161702.1 AJ133790.2 AY077681.1 BC074942.2 BC074943.2 

    3 DOTS entries:

    DT.97840595  DT.121443970  DT.97840594 

    24/66 AceView cDNA sequences (see all 66):

    BF725338 BF724806 BM706920 AA296926 BF724488 BM664671 NM_014359 BM703173 
    BU732478 BM709327 CA396741 CA393129 BF725760 BF724362 CA396257 CA390246 
    BF725777 CA396840 BC074943 BF725728 BM686909 CA394867 BF725475 BF724320 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OPTC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                                            
    SP2:                    -                                       


    ECgene alternative splicing isoforms for OPTC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPTC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGGGAGG
    OPTC Expression
    About this image


    See OPTC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPTC

    SOURCE GeneReport for Unigene cluster: Hs.632468

    UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
    Tissue specificity: Retina, iris, ligament, skin and fetal liver

        SABiosciences Custom PCR Arrays for OPTC
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OPTC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPTC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPTC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPTC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPTC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OPTC gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Optc1 , 5 opticin1, 5 77.95(n)1
    73.78(a)1
      1 (58.02 cM)5
    2691201  NM_054076.31  NP_473417.21 
     1338971995 
    chicken
    (Gallus gallus)
    Aves OPTC1 opticin 63.58(n)
    56.79(a)
      395130  NM_204473.1  NP_989804.1 
    lizard
    (Anolis carolinensis)
    Reptilia OPTC6
    opticin
    53(a)
    1 ↔ 1
    4(118566470-118588425)
    zebrafish
    (Danio rerio)
    Actinopterygii optc1 opticin 57.26(n)
    52.99(a)
      445189  NM_001003583.1  NP_001003583.1 


    ENSEMBL Gene Tree for OPTC (if available)
    TreeFam Gene Tree for OPTC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPTC gene
    OGN2  EPYC2  
    3 SIMAP similar genes for OPTC using alignment to 3 protein entries:     OPT_HUMAN (see all proteins):
    OGN    EPYC    RTN4RL2

    OPTC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/433 SNPs in OPTC are shown (see all 433)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28028011,2
    C,F,O--174626324(+) CAGGAG/CCGTAT 1 -- us2k18Minor allele frequency- C:0.28NA WA CSA EA 368
    rs1920642201,2
    --174626367(+) CAGGCA/GGCAGG 1 -- us2k10--------
    rs1828724401,2
    --174626392(+) ACTCGC/TATTTG 1 -- us2k10--------
    rs611408641,2
    C,F--174626399(+) TTTGCA/CTTTCT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs284633601,2
    C,F--174626432(+) GGGAGG/CGGGGA 1 -- us2k17Minor allele frequency- C:0.42WA NA EA 366
    rs28028021,2
    C,F--174626462(+) GGGGGC/TGGAGG 1 -- us2k19Minor allele frequency- T:0.32WA NA CSA EA 367
    rs102178131,2
    C--174626463(+) GGGGTG/AGAGGG 1 -- us2k15Minor allele frequency- A:0.38NA WA EA 362
    rs761780401,2
    F--174626575(+) TTTCCC/TTCCAC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs755305521,2
    F--174626615(+) CAGGTG/TGGGGG 1 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs1883946141,2
    --174626680(+) GGAAGC/TCCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OPTC (203463271 - 203478077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OPTC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1567874CNV Insertion17803354


    Human Gene Mutation Database (HGMD): OPTC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OPTC
    DNA2.0 Custom Variant and Variant Library Synthesis for OPTC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605127    OMIM disorders: --

    20 diseases for OPTC:    About MalaCards
    asthenopia    vitreous detachment    choroiditis    posterior column ataxia
    eye disease    macular degeneration    astigmatism    age related macular degeneration
    open-angle glaucoma    primary open angle glaucoma    skeletal dysplasias    glaucoma
    ataxia    myopia    neurofibromatosis    essential hypertension
    osteoarthritis    hypertension    retinitis    hypoxia

    1 disease from the University of Copenhagen DISEASES database for OPTC:
    Vitreous detachment

    OPTC for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for OPTC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    collagen fibril 80.7 2 15090426 (1), 11814684 (1)
    glaucoma open-angle 48.8 3 12019215 (1), 17359525 (1)

    Genetic Association Database (GAD): OPTC
    Human Genome Epidemiology (HuGE) Navigator: OPTC (5 documents)

    Export disorders for OPTC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPTC gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with OPTC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. (PubMed id 10636917)1, 2, 3, 9 Reardon A.J.... Bishop P.N. (2000)
    2. Protein localization in the human eye and genetic screen of opticin. (PubMed id 12019215)1, 2, 9 Friedman J.S.... Walter M.A. (2002)
    3. An evaluation of OPTC and EPYC as candidate genes for high myopia. (PubMed id 19844586)1, 4, 9 Wang P....Zhang Q. (2009)
    4. Cloning, modeling, and chromosomal localization for a small leucine- rich repeat proteoglycan (SLRP) family member expressed in human eye. (PubMed id 10837509)1, 2, 9 Hobby P....Wistow G.J. (2000)
    5. Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. (PubMed id 17359525)1, 4, 9 Acharya M....Ray K. (2007)
    6. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    7. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    8. Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. (PubMed id 17563717)1, 4 Kumar A....Dorairaj S.K. (2007)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26254 HGNC: 8158 AceView: OPTC Ensembl:ENSG00000188770 euGenes: HUgn26254
    ECgene: OPTC H-InvDB: OPTC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPTC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OPTC gene:
    Search GeneIP for patents involving OPTC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for OPTC (Opticin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OPTC  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OPTC  
     OriGene MassSpec something-or-other for OPTC   OriGene clones in human, mouse for OPTC  
     OriGene qSTAR qPCR primer pairs in human, mouse for OPTC   OriGene Purified Protein for OPTC  
     OriGene ORF clones in mouse, rat for OPTC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OPTC   OriGene Custom Protein Services for OPTC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OPTC
     QIAGEN SeqTarget long-range PCR primers for resequencing OPTC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPTC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPTC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPTC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPTC
     GenScript Custom Purified and Recombinant Proteins Services for OPTC GenScript cDNA clones with any tag delivered in your preferred vector for OPTC
     GenScript Custom Assay Services for OPTC GenScript Custom Superior Antibodies Services for OPTC
     GenScript Custom overexpressing Cell Line Services for OPTC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OPTC promoter
     Search Chromatin IP Primers for OPTC
     RT2 qPCR Primer Assay in human, mouse, rat OPTC
     Search GNC Networks for OPTC
     SABiosciences Custom PCR Arrays for OPTC
     Search Tocris compounds for OPTC (OPT)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OPTC antibodies
     OPTC lysates
     Antibodies for OPTC
     See all of Abcam's Antibodies, Kits and Proteins for OPTC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OPTC
     Antibodies for OPTC
     ELISAs for OPTC
     CLIAs for OPTC
     Search LifeMap BioReagents cell lines for OPTC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPTC
     SwitchGear 3'UTR luciferase reporter plasmids for OPTC
     SwitchGear Promoter luciferase reporter plasmids for OPTC
     Search ThermoFisher Antibodies for OPTC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPTC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OPTC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OPTC
    Customized:
     lentivirus for stable overexpression of OPTC
     lentivirus expression plasmids for stable overexpression of OPTC
     adenovirus for overexpression of OPTC
     LSBio Antibodies in human, mouse, rat for OPTC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OPTC gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4