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OPTC Gene

protein-coding   GIFtS: 53
GCID: GC01P203464

Opticin

  See OPTC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
opticin1 2
oculoglycan1 2
OPT2 3
Oculoglycan3

External Ids:    HGNC: 81581   Entrez Gene: 262542   Ensembl: ENSG000001887707   OMIM: 6051275   UniProtKB: Q9UBM43   

Export aliases for OPTC gene to outside databases

Previous GC identifers: GC01M201246 GC01M198990 GC01P9D0052 GC00P9S0052 GC01P200194 GC01P201729 GC01P174628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPTC Gene:
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are
typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous
of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver.
Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The
opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related
macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). (provided by RefSeq, Jul
2008)

GeneCards Summary for OPTC Gene:
OPTC (opticin) is a protein-coding gene. Diseases associated with OPTC include posterior column ataxia, and vitreous detachment. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OGN.

UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
Function: Binds collagen fibrils (By similarity)

Gene Wiki entry for OPTC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPTC gene promoter:
         Oct-B1   GR   oct-B3   oct-B2   MEF-2   MEF-2A   IRF-2   POU2F1   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPTC promoter sequence
   Search Chromatin IP Primers for OPTC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPTC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

OPTC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPTC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203464:  view genomic region     (about GC identifiers)

Start:
203,463,271 bp from pter      End:
203,478,077 bp from pter
Size:
14,807 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4 (See protein sequence)
Recommended Name: Opticin precursor  
Size: 332 amino acids; 37261 Da
Secondary accessions: Q5T2G4

Explore the universe of human proteins at neXtProt for OPTC: NX_Q9UBM4

Explore proteomics data for OPTC at MOPED

Post-translational modifications: 

  • O-glycosylated (Probable)1
  • Glycosylation2 at Asn312

  • See OPTC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055174.1  
    ENSEMBL proteins: 
     ENSP00000356191   ENSP00000399491  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q9UBM4

    ProtoNet protein and cluster: Q9UBM4

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with OPTC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPT_HUMAN, Q9UBM4
    Function: Binds collagen fibrils (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS10636917
    GO:0005515protein binding ----
         
    Find genes that share ontologies with OPTC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OPTC:
     Decreased Hepatitis C virus re 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Optc):
     cardiovascular system  vision/eye 

    Find genes that share phenotypes with OPTC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Optctm1.1Pnb for OPTC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPTC
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPTC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPTC

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    2 qRT-PCR Assays for microRNAs that regulate OPTC:
    hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidOPTC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OPTC

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPT_HUMAN, Q9UBM4: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with OPTC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OPTC
    Interactions:

        Search GeneGlobe Interaction Network for OPTC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OPTC (Q9UBM43 ENSP000003561914) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    PDGFRLENSP000002516304STRING: ENSP00000251630
    IGFBP7ENSP000002956664STRING: ENSP00000295666
    MXRA8ENSP000003078874STRING: ENSP00000307887
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016525negative regulation of angiogenesis IEA--

    Find genes that share ontologies with OPTC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OPTC (OPT)

    1 Novoseek inferred chemical compound relationship for OPTC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 16.4 1 11814684 (1)



    Find genes that share compounds with OPTC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OPTC gene: 
    NM_014359.3  

    Unigene Cluster for OPTC:

    Opticin
    Hs.632468  [show with all ESTs]
    Unigene Representative Sequence: NM_014359
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367222(uc001gzu.1) ENST00000448911
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate OPTC:
    hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidOPTC 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OPTC
      QuantiTect SYBR Green Assays in human, mouse, rat OPTC
      QuantiFast Probe-based Assays in human, mouse, rat OPTC

    Additional mRNA sequence: 

    AF161702.1 AJ133790.2 AY077681.1 BC074942.2 BC074943.2 

    3 DOTS entries:

    DT.97840595  DT.121443970  DT.97840594 

    Selected AceView cDNA sequences (see all 66):

    CA393737 CA389205 AJ133790 CA390988 AA317820 BM693661 BF725864 AA318186 
    CA395771 BF725807 BF725338 BF724806 BM706920 AA296926 BF724488 BM664671 
    NM_014359 BM703173 BU732478 BM709327 CA396741 CA393129 BF725760 BF724362 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OPTC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                                            
    SP2:                    -                                       


    ECgene alternative splicing isoforms for OPTC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OPTC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGGGAGG
    OPTC Expression
    About this image

    OPTC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPTC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632468

    UniProtKB/Swiss-Prot: OPT_HUMAN, Q9UBM4
    Tissue specificity: Retina, iris, ligament, skin and fetal liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPTC gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Optc1 , 5 opticin1, 5 77.18(n)1
    73.57(a)1
      1 (58.02 cM)5
    2691201  NM_054076.31  NP_473417.21 
     1338971995 
    chicken
    (Gallus gallus)
    Aves OPTC1 opticin 64.3(n)
    56.45(a)
      395130  NM_204473.1  NP_989804.1 
    lizard
    (Anolis carolinensis)
    Reptilia OPTC6
    opticin
    52(a)
    1 ↔ 1
    4(118566470-118588425)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia optc1 opticin 56.54(n)
    51.31(a)
      549253  NM_001016499.2  NP_001016499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii optc1 opticin 57.16(n)
    50(a)
      445189  NM_001003583.2  NP_001003583.2 


    ENSEMBL Gene Tree for OPTC (if available)
    TreeFam Gene Tree for OPTC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPTC gene
    OGN2  EPYC2  
    2 SIMAP similar genes for OPTC using alignment to 3 protein entries:     OPT_HUMAN (see all proteins):
    OGN    EPYC

    Find genes that share paralogs with OPTC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPTC (see all 433)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28028011,2
    C,F,O--174626324(+) CAGGAG/CCGTAT 1 -- us2k18Minor allele frequency- C:0.28NA WA CSA EA 368
    rs1920642201,2
    --174626367(+) CAGGCA/GGCAGG 1 -- us2k10--------
    rs1828724401,2
    --174626392(+) ACTCGC/TATTTG 1 -- us2k10--------
    rs611408641,2
    C,F--174626399(+) TTTGCA/CTTTCT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs284633601,2
    C,F--174626432(+) GGGAGG/CGGGGA 1 -- us2k17Minor allele frequency- C:0.42WA NA EA 366
    rs28028021,2
    C,F--174626462(+) GGGGGC/TGGAGG 1 -- us2k19Minor allele frequency- T:0.32WA NA CSA EA 367
    rs102178131,2
    C--174626463(+) GGGGTG/AGAGGG 1 -- us2k15Minor allele frequency- A:0.38NA WA EA 362
    rs761780401,2
    F--174626575(+) TTTCCC/TTCCAC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs755305521,2
    F--174626615(+) CAGGTG/TGGGGG 1 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs1883946141,2
    --174626680(+) GGAAGC/TCCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OPTC (203463271 - 203478077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OPTC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1567874CNV Insertion17803354

    Human Gene Mutation Database (HGMD): OPTC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPTC
    DNA2.0 Custom Variant and Variant Library Synthesis for OPTC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605127    OMIM disorders: --

    3 diseases for OPTC:    
    About MalaCards
    posterior column ataxia    vitreous detachment    skeletal dysplasias

    1 disease from the University of Copenhagen DISEASES database for OPTC:
    Vitreous detachment

    Find genes that share disorders with OPTC           About GenesLikeMe

    2 Novoseek inferred disease relationships for OPTC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    collagen fibril 80.7 2 15090426 (1), 11814684 (1)
    glaucoma open-angle 48.8 3 12019215 (1), 17359525 (1)

    Genetic Association Database (GAD): OPTC
    Human Genome Epidemiology (HuGE) Navigator: OPTC (5 documents)

    Export disorders for OPTC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPTC gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with OPTC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. (PubMed id 10636917)1, 2, 3, 9 Reardon A.J.... Bishop P.N. (J. Biol. Chem. 2000)
    2. Protein localization in the human eye and genetic screen of opticin. (PubMed id 12019215)1, 2, 9 Friedman J.S.... Walter M.A. (Hum. Mol. Genet. 2002)
    3. An evaluation of OPTC and EPYC as candidate genes for high myopia. (PubMed id 19844586)1, 4, 9 Wang P....Zhang Q. (Mol. Vis. 2009)
    4. Cloning, modeling, and chromosomal localization for a small leucine- rich repeat proteoglycan (SLRP) family member expressed in human eye. (PubMed id 10837509)1, 2, 9 Hobby P....Wistow G.J. (Mol. Vis. 2000)
    5. Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. (PubMed id 17359525)1, 4, 9 Acharya M....Ray K. (BMC Mol. Biol. 2007)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    8. Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. (PubMed id 17563717)1, 4 Kumar A....Dorairaj S.K. (Mol. Vis. 2007)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26254 HGNC: 8158 AceView: OPTC Ensembl:ENSG00000188770 euGenes: HUgn26254
    ECgene: OPTC H-InvDB: OPTC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OPTC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPTC gene:
    Search GeneIP for patents involving OPTC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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