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Aliases for OPRPN Gene

Aliases for OPRPN Gene

  • Opiorphin Prepropeptide 2 3 5
  • Basic Proline-Rich Lacrimal Protein 3 4
  • Proline Rich, Lacrimal 1 2 3
  • Proline-Rich Protein 1 3 4
  • PROL1 3 4
  • BPLP 3 4
  • PRL1 3 4
  • Basic Proline-Rich Protein 3
  • Proline Rich 1 2
  • Proline-Rich 1 3
  • Opiorphin 3

External Ids for OPRPN Gene

Previous HGNC Symbols for OPRPN Gene

  • PROL1

Summaries for OPRPN Gene

Entrez Gene Summary for OPRPN Gene

  • This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for OPRPN Gene

OPRPN (Opiorphin Prepropeptide) is a Protein Coding gene.

UniProtKB/Swiss-Prot for OPRPN Gene

  • Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRPN Gene

Genomics for OPRPN Gene

Regulatory Elements for OPRPN Gene

Enhancers for OPRPN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G070372 0.4 FANTOM5 0.3 -25.6 -25598 0.1 ATF2 CABS1 SMR3B OPRPN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OPRPN on UCSC Golden Path with GeneCards custom track

Genomic Location for OPRPN Gene

Chromosome:
4
Start:
70,397,882 bp from pter
End:
70,410,197 bp from pter
Size:
12,316 bases
Orientation:
Plus strand

Genomic View for OPRPN Gene

Genes around OPRPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRPN Gene

Proteins for OPRPN Gene

  • Protein details for OPRPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99935-PROL1_HUMAN
    Recommended name:
    Opiorphin prepropeptide
    Protein Accession:
    Q99935
    Secondary Accessions:
    • A8MZ07
    • P85047

    Protein attributes for OPRPN Gene

    Size:
    248 amino acids
    Molecular mass:
    27217 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB46823.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305};

neXtProt entry for OPRPN Gene

Post-translational modifications for OPRPN Gene

No Post-translational modifications

Other Protein References for OPRPN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OPRPN Gene

Domains & Families for OPRPN Gene

Protein Domains for OPRPN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OPRPN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99935

UniProtKB/Swiss-Prot:

PROL1_HUMAN :
  • Belongs to the PROL1/PROL3 family.
Family:
  • Belongs to the PROL1/PROL3 family.
genes like me logo Genes that share domains with OPRPN: view

No data available for Gene Families for OPRPN Gene

Function for OPRPN Gene

Molecular function for OPRPN Gene

UniProtKB/Swiss-Prot Function:
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.

Gene Ontology (GO) - Molecular Function for OPRPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IDA 17101991
GO:0030414 peptidase inhibitor activity IEA,IDA 17101991
genes like me logo Genes that share ontologies with OPRPN: view

Phenotypes for OPRPN Gene

genes like me logo Genes that share phenotypes with OPRPN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OPRPN Gene

Localization for OPRPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRPN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPRPN gene
Compartment Confidence
extracellular 5
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OPRPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 17101991
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with OPRPN: view

Pathways & Interactions for OPRPN Gene

SuperPathways for OPRPN Gene

No Data Available

Interacting Proteins for OPRPN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000382485%0d%0a9606.ENSP00000246895%0d%0a
Selected Interacting proteins: Q99935-PROL1_HUMAN ENSP00000382485 for OPRPN Gene via IID STRING

Gene Ontology (GO) - Biological Process for OPRPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0051930 regulation of sensory perception of pain IDA 17101991
genes like me logo Genes that share ontologies with OPRPN: view

No data available for Pathways by source and SIGNOR curated interactions for OPRPN Gene

Drugs & Compounds for OPRPN Gene

No Compound Related Data Available

Transcripts for OPRPN Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRPN Gene

No ASD Table

Relevant External Links for OPRPN Gene

GeneLoc Exon Structure for
OPRPN
ECgene alternative splicing isoforms for
OPRPN

Expression for OPRPN Gene

NURSA nuclear receptor signaling pathways regulating expression of OPRPN Gene:

OPRPN

mRNA Expression by UniProt/SwissProt for OPRPN Gene:

Q99935-PROL1_HUMAN
Tissue specificity: Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.

Evidence on tissue expression from TISSUES for OPRPN Gene

  • Eye(4.9)
  • Saliva(4.4)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPRPN Gene

Orthologs for OPRPN Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for OPRPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROL1 34 35
  • 97.85 (n)
Species where no ortholog for OPRPN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OPRPN Gene

ENSEMBL:
Gene Tree for OPRPN (if available)
TreeFam:
Gene Tree for OPRPN (if available)

Paralogs for OPRPN Gene

No data available for Paralogs for OPRPN Gene

Variants for OPRPN Gene

Sequence variations from dbSNP and Humsavar for OPRPN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000163988 -- 70,400,429(+) TGTAT(-/A)AAAAA intron-variant
rs1000239388 -- 70,397,911(+) GGTAT(A/T)TAAGA nc-transcript-variant, utr-variant-5-prime
rs1000493427 -- 70,406,578(+) TTGCC(A/T)AGTGA intron-variant
rs1000562934 -- 70,403,469(+) TGGCA(C/T)GTAAA intron-variant
rs1000626462 -- 70,404,825(+) TTTAT(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRPN Gene

Variant ID Type Subtype PubMed ID
dgv321n21 CNV loss 19592680
dgv9127n54 CNV loss 21841781
esv2759259 CNV loss 17122850
nsv1006332 CNV loss 25217958
nsv1012495 CNV gain 25217958
nsv461554 CNV loss 19166990
nsv470046 CNV loss 18288195
nsv829964 CNV gain 17160897

Variation tolerance for OPRPN Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRPN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPRPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRPN Gene

Disorders for OPRPN Gene

Relevant External Links for OPRPN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRPN

No disorders were found for OPRPN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPRPN Gene

Publications for OPRPN Gene

  1. cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein. (PMID: 8670737) Dickinson D.P. … Thiesse M. (Curr. Eye Res. 1996) 2 3 4 22 64
  2. Human opiorphin, a natural antinociceptive modulator of opioid- dependent pathways. (PMID: 17101991) Wisner A. … Rougeot C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 64
  3. Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification. (PMID: 25946035) Azkargorta M. … Elortza F. (J. Proteome Res. 2015) 4 64
  4. Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. (PMID: 24803544) Fu S. … Davies K.P. (FASEB J. 2014) 3 64
  5. Peptides in seminal fluid and their role in infertility: a potential role for opiorphin inhibition of neutral endopeptidase activity as a clinically relevant modulator of sperm motility: a review. (PMID: 24855109) Bosler J.S. … Neal-Perry G.S. (Reprod Sci 2014) 3 64

Products for OPRPN Gene

Sources for OPRPN Gene

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