OPRM1 Gene
protein-coding GIFtS : 67 GCID: GC06 P154391
opioid receptor, mu 1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor OPRM1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Opioid Receptor, Mu 1 1 2 OPRM2 MOR11 2 3 Mu Opioid Receptor HMOR-1a2 Mu Opiate Receptor2 3 Mu-Type Opioid Receptor2 M-OR-12 3 MOR-13 MOP2 3 HMOP1 LMOR2 Mu Opioid Receptor3 MOR2
Export aliases for OPRM1 gene to outside databases Previous GC identifers: GC06P153921 GC06P154255 GC06P154452 GC06P151895
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor OPRM1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for OPRM1 : This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2012) UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 Function : Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and syntheticopioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity summary
for OPRM1 : The mu opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupledreceptors that also includes kappa, delta and NOP receptors. Three variants of the receptor designated mu1,mu2 and mu3 have been characterized, arising from the alternative splicing of the this gene. mu Opioidreceptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus,amygdala) and in the peripheral nervous system (myenteric neurons and vas deferens). mu Opioid receptorshave been implicated in respiration, cardiovascular functions, feeding, learning and memory, intestinaltransit, locomotor activity, thermoregulation, hormone secretion and immune functions. The human geneencoding the mu opioid receptor has been localized to chromosome 6 (6q24-q25). Gene Wiki entry for OPRM1 (Mu Opioid receptor)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor OPRM1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OPRM1 gene promoter:NRSF form 1 NRSF form 2 Other transcription factors Search SABiosciences Chromatin IP Primers for OPRM1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q24-q25 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q24-q25 OPRM1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P154391: view genomic region
(about GC identifiers )
Start: 154,331,631 bp from pter End:
154,568,001 bp from pter
Size: 236,371 bases Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor OPRM1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 See
protein sequence )Recommended Name: Size : 400 amino acids; 44779 DaSubunit : Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2,CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity)
Subcellular location : Cell membrane; Multi-pass membrane proteinSubcellular location : Isoform 12: CytoplasmMiscellaneous : OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediatedinhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation
Sequence caution : Sequence=CAI20458.1; Type=Erroneous initiation; Sequence=EAW47705.1; Type=Erroneous initiation;Secondary accessions : B0FXJ1 B2R9S7 B8Q1L7 B8Q1L8 B8Q1L9 G8XRH6 G8XRH8 Q12930 Q4VWM1 Q4VWM2 Q4VWM3Q4VWM4 Q4VWM6 Q4VWX6 Q5TDA1 Q6UPP1 Q6UQ80 Q7Z2D8 Q86V80 Q8IWW3 Q8IWW4 Q9UCZ4 Q9UN57 Alternative splicing : 17 isoforms : P35372-1 P35372-2 P35372-3 P35372-4 P35372-5 P35372-6 P35372-7 P35372-8 P35372-9 P35372-10 P35372-11 P35372-12 P35372-13 P35372-14 P35372-15 P35372-16 P35372-17 (Ref.5 (AAQ77392) sequence differs from that shown due to a polymorphism leading to premature termination of translation (position: 411:Q->Stop))Explore the universe of human proteins at neXtProt for OPRM1: NX_P35372 Post-translational modifications:
Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by ADRBK1 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agoinist-induced G-protein-indepenedent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity)1
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4 (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P35372 OPRM1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (13 alternative transcripts): NP_000905.3 NP_001008503.2 NP_001008504.2 NP_001008505.2 NP_001138751.1 NP_001138752.1 NP_001138753.1 NP_001138754.1 NP_001138755.1 NP_001138756.1 NP_001138757.1 NP_001138758.1 NP_001138759.1 ENSEMBL proteins: ENSP00000430247 ENSP00000394624 ENSP00000430876 ENSP00000430260 ENSP00000328264 ENSP00000411903 ENSP00000410497 ENSP00000428018 ENSP00000430575 ENSP00000229768 ENSP00000403549 ENSP00000430097 ENSP00000431048 ENSP00000399359 ENSP00000413752 ENSP00000338381 ENSP00000429719 ENSP00000429373 ENSP00000353598 Reactome Protein details: P35372 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing OPRM1 Antibody Products: Assay Products for OPRM1:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for OPRM1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P35372 ProtoNet protein and cluster: P35372
2 Blocks protein families : IPB000105 IPB001418 UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 Similarity : Belongs to the G-protein coupled receptor 1 family
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor OPRM1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 Function : Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and syntheticopioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity
Genatlas biochemistry entry for OPRM1 opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid peptides,also major target for opioid analgesic agents and heroin and a third splice varient acting as a morphine-6 beta-glucuronide receptor,depressing cAMP levels,opening a G protein-modulated K+ channel Clone EMD Millipore Clones for the Expression of OPRM1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 19 )human mouse rat see all 13 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 13 ): OPRM1 (NM_001008503 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPRM1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OPRM1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRM1
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001965 G-protein alpha-subunit binding
IDA -- GO:0004930 G-protein coupled receptor activity
ISS -- GO:0004979 beta-endorphin receptor activity
IMP 9689128 GO:0004985 opioid receptor activity
-- -- GO:0005245 voltage-gated calcium channel activity
ISS --
About GeneDecksing Animal Models: Oprm1 tm1Yxp Oprm1 tm1Loh Oprm1 tm1Lyu Oprm1 tm1Kff Oprm1 tm1Jep Oprm1 tm1Uhl Oprm1 tm1Lex 15 MGI mutant phenotypes (inferred from 14 alleles(MGI details for Oprm1) :About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor OPRM1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Class A/1 (Rhodopsin-like receptors) 2 Signaling by GPCR 3 Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q 4 Neuroscience 5 Opioid Signalling
Pathway sources See GeneCards unified pathways Show all pathways 1 1 4 5/9 (see all 9 )1 (Kegg details for OPRM1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPRM1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/164 Interacting proteins for OPRM1 (P35372 1 , 3 ENSP00000394624 4 via UniProtKB, MINT, STRING , and/or I2D (see all 164 )About this table Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
TAS 7905839 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
IEA -- GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
IEA -- GO:0007194 negative regulation of adenylate cyclase activity
ISS -- GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
ISS --
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor OPRM1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for OPRM1
Compounds for OPRM1 available from Tocris Bioscience About this table 3 HMDB Compounds for OPRM1 About this table 10/38 DrugBank Compounds for OPRM1 (see all 38 )About this table 10/130 Novoseek chemical compound relationships for OPRM1 gene (see all 130 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
damgo
93.9
126
16682505 (7), 10617147 (4), 9544801 (4), 14743438 (2) (see all 77 )
morphine
90.5
366
16682505 (7), 15504181 (6), 10688980 (6), 11118335 (5) (see all 99 )
naloxone
88.1
61
9605673 (2), 9415708 (2), 9106259 (1), 9282948 (1) (see all 52 )
alvimopan
87.7
14
17340127 (2), 12431026 (1), 15772912 (1), 17042776 (1) (see all 12 )
etorphine
86.5
6
9852117 (2), 18358497 (1), 8618916 (1), 9350996 (1)
beta funaltrexamine
86.5
58
7805771 (3), 1364844 (2), 9862398 (2), 11500514 (2) (see all 30 )
opiate
85.6
93
9153634 (4), 18181266 (2), 19103668 (2), 10393893 (2) (see all 63 )
[3h]diprenorphine
85.4
9
7805771 (1), 12905615 (1), 15857313 (1), 11076532 (1) (see all 7 )
naltrexone
81.9
62
17768272 (3), 16899031 (2), 18028530 (2), 17374034 (2) (see all 37 )
dpdpe
78.8
10
7925596 (1), 11165441 (1), 8386968 (1), 8947072 (1) (see all 10 )
6 PharmGKB related drug/compound annotations for OPRM1 gene About this table OPRM1 / OPRM
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor OPRM1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OPRM1 gene (13 alternative transcripts): NM_000914.3 NM_001008503.1 NM_001008504.2 NM_001008505.1 NM_001145279.2 NM_001145280.2 NM_001145281.1 NM_001145282.1 NM_001145283.1 NM_001145284.2 NM_001145285.1 NM_001145286.1 NM_001145287.1 Unigene Cluster for OPRM1:
Opioid receptor, mu 1 Hs.2353 [show with all ESTs ] Unigene Representative Sequence: NM_001145287 18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23 ): ENST00000520282 ENST00000434900 (uc011efb.2 ) ENST00000520708 ENST00000518759 ENST00000330432 (uc011efd.2 uc011efe.2 uc011efc.1 uc003qpr.2 uc003qps.2 )ENST00000428397 (uc003qpn.2 ) ENST00000523520 ENST00000452687 ENST00000522739 ENST00000524150 ENST00000229768 (uc003qpo.1 ) ENST00000419506 (uc011eff.1 )ENST00000524163 ENST00000519083 (uc003qpp.2 ) ENST00000414028 (uc011efi.2 )ENST00000435918 (uc011efh.1 ) ENST00000337049 ENST00000519613 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 19 )human mouse rat see all 13 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 13 ): OPRM1 (NM_001008503 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPRM1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OPRM1
Additional cDNA sequence: AK309655.1 AK313901.1 AY036622.1 AY036623.1 AY195733.2 AY225404.1 AY309001.1 AY309005.1 AY309006.1 AY309007.1 AY309008.1 AY364230.1 AY364890.1 AY521028.1 BC074927.2 DQ680044.1 EF666090.1 EU340241.1 EU340242.1 EU340243.1 EU360599.2 EU362990.2 FJ041290.1 FJ041291.1 FJ041292.1 FJ041293.1 FJ041294.1 GQ258059.1 HQ699462.1 JX914655.1 L25119.1 L29301.1 U12569.1
4 DOTS entries : DT.306401 DT.100690305
DT.92414497 DT.102820783 12 AceView cDNA sequences :
AY036623 AY521028 AY364230 BC074927 AY364890 L29301 U12569 AY195733 AY036622 NM_000914 BP346782 L25119 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 (see all 14 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 SP1 : - - - - - - - - - - - SP2 : - - - - - - - - SP3 : - - - - - - - - - - - - SP4 : - - - - - - - - - - - SP5 : - - - - - - - - - - - - - -
ECgene alternative splicing isoforms for OPRM1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for OPRM1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OPRM1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AACCCTAAAA
About this image See OPRM1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OPRM1 SOURCE GeneReport for Unigene cluster: Hs.2353 UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 Tissue specificity : Expressed in brain. Isoform 16 and isoform 17 are detected in brainSABiosciences Expression via Pathway-Focused PCR Arrays including OPRM1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRM1
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor OPRM1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for OPRM1 gene from 5/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves OPRM11
opioid receptor, mu 1
84.21(n) 95.67(a)
421644 XM_003640960.1 XP_003641008.1
lizard Reptilia OPRM16
--
81(a)
1 ↔ 1
1(215254058-215276401)
zebrafish Actinopterygii oprm12
opioid receptor, mu 1
76.21(n)
65088 AF132813.1
fruit fly Insecta AlCR23
G-protein coupled receptor protein signalingless
36(a)
75D1 --
worm Secernentea Y54E2A.16
--
11(a)
possible ortholog
II(14734335-14739167)
ENSEMBL Gene Tree for OPRM1 (if available)TreeFam Gene Tree for OPRM1 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor OPRM1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OPRM1 gene SSTR3 2 OPRD1 2 SSTR4 2 GALR2 2 MCHR2 2 SSTR1 2 GALR3 2 OPRL1 2 NPBWR1 2 OPRK1 2 KISS1R 2 GALR1 2 SSTR5 2 SSTR2 2 MCHR1 2 NPBWR2 2 18/56 SIMAP similar genes for OPRM1 using alignment to 18 protein entries: OPRM_HUMAN (see all proteins )
(see all similar genes ):OPRMI OPRK1 OPRD1 OPRL1 SSTR4 CCR3 CHRM2 NPBWR2 SSTR2 SSTR5 SSTR3 SSTR1 NPBWR1 P2RY4 CCR-5 CMKLR1 GALR1 CCR5 About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor OPRM1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 Polymorphism : Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested,but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 6 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for OPRM1 (154331631 - 154568001 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for OPRM1 2 CNVs 51827 99763 9 Indels 47024 47023 42606 40933 28126 62590 99762 40932 12870 1 Inversion 59836 Human Gene Mutation Database (HGMD) : OPRM1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor OPRM1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600018
OMIM disorders : --20/76 (see all 76 ): About MalaCards alcoholism heroin dependence temporal lobe epilepsy alcohol dependence ileus spinal cord injury patent ductus arteriosus idiopathic generalized epilepsy opioid abuse hemiplegic migraine back pain familial hemiplegic migraine tardive dyskinesia chronic pain substance dependence somatoform disorder complex partial epilepsy blindness anorexia nervosa fibromyalgia 6 diseases from the University of Copenhagen DISEASES database for OPRM1 :Pain agnosia Alcohol dependence Opiate dependence Withdrawal disorder Histrionic personality disorder Nicotine dependence 10/58 Novoseek disease relationships for OPRM1 gene (see all 58 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
opioid dependence
73.8
26
12960749 (5), 17416470 (5), 15558714 (3), 12648891 (2) (see all 12 )
heroin addiction
70
6
18518925 (1), 10911931 (1), 16682632 (1), 17416470 (1) (see all 6 )
respiratory depression
64.7
8
15731588 (2), 17922561 (1), 19461299 (1), 16029065 (1) (see all 6 )
hyperalgesia
61.2
4
14504663 (1), 20357116 (1), 12750434 (1), 19590003 (1)
substance dependence
60.5
18
12815747 (4), 16476706 (2), 16451620 (1), 12960749 (1) (see all 11 )
alcoholism
56.5
47
17979515 (4), 15902904 (3), 9884158 (3), 16476706 (2) (see all 28 )
drug dependence
53.7
10
9756053 (2), 16476706 (1), 9399694 (1), 19430912 (1) (see all 7 )
dependence psychological
52.8
1
11316510 (1)
drug addiction
48.7
4
11067846 (1), 16046395 (1), 11506703 (1), 20196742 (1)
cocaine addiction
40
1
11458541 (1)
Genetic Association Database (GAD): OPRM1 Human Genome Epidemiology (HuGE) Navigator: OPRM1 (158 documents) Export disorders for OPRM1 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor OPRM1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OPRM1 gene, integrated from 9 sources (see all 1175 ):(articles sorted by number of sources associating them with OPRM1) Utopia : connect your pdf to the dynamic
Mu opioid receptor gene variants: lack of association with alcohol dependence. (PubMed id 9399694) 1 , 2 , 4, 9(1997) Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. (PubMed id 11933204) 1 , 4, 7, 9(2002) The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. (PubMed id 16580639) 1 , 2 , 7, 9(2006) Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking. (PubMed id 14573758) 1 , 2 , 9(2003) Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. (PubMed id 15731588) 1 , 4, 9(2005) A genetic association study of the mu opioid receptor and severe opioid dependence. (PubMed id 12960749) 1 , 4, 9(2003) A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PubMed id 16542645) 1 , 2 , 9(2006) Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. (PubMed id 15558714) 1 , 4, 9(2005) The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. (PubMed id 15772909) 1 , 4, 9(2005) Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. (PubMed id 15542732) 1 , 4, 9(2004)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for OPRM1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing OPRM1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing OPRM1 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing OPRM1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for OPRM1 Pharmacogenomics, SNPs, Pathways Wikipedia http://en.wikipedia.org/wiki/Mu_opioid_receptor NIEHS-SNPs http://egp.gs.washington.edu/data/oprm1/
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for OPRM1 gene: OPRM1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor OPRM1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for OPRM1 OriGene shRNA RFP for OPRM1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for OPRM1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OPRM1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for OPRM1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OPRM1 OriGene Custom Protein Services for OPRM1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OPRM1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for OPRM1 (MOR-1)
Tocris compounds for OPRM1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRM1
ThermoFisher Antibody for OPRM1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OPRM1
Jump to Section...
Aliases for OPRM1
Databases for OPRM1
Disorders / Diseases for OPRM1
Domains / Families for OPRM1
Drugs / Compounds for OPRM1
Expression for OPRM1
Function for OPRM1
Genomic Views for OPRM1
Intellectual Property for OPRM1
Orthologs for OPRM1
Paralogs for OPRM1
Pathways / Interactions for OPRM1
Products for OPRM1
Proteins for OPRM1
Publications for OPRM1
Search Box for OPRM1
Summaries for OPRM1
Transcripts for OPRM1
Variants for OPRM1
TOP
BOTTOM
summary
for 
