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Aliases for OPRM1 Gene

Aliases for OPRM1 Gene

  • Opioid Receptor, Mu 1 2 3
  • Mu Opiate Receptor 3 4
  • M-OR-1 3 4
  • MOR1 3 4
  • MOP 3 4
  • Mu Opioid Receptor HMOR-1a 3
  • Mu-Type Opioid Receptor 3
  • Mu Opioid Receptor 4
  • MOR-1 4
  • LMOR 3
  • OPRM 3
  • HMOP 4
  • MOR 3

External Ids for OPRM1 Gene

Summaries for OPRM1 Gene

Entrez Gene Summary for OPRM1 Gene

  • This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

GeneCards Summary for OPRM1 Gene

OPRM1 (Opioid Receptor, Mu 1) is a Protein Coding gene. Diseases associated with OPRM1 include opioid abuse and complex partial epilepsy. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein alpha-subunit binding. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRM1 Gene

  • Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity

Tocris Summary for OPRM1 Gene

  • The mu opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and NOP receptors. Three variants of the receptor designated mu1, mu2 and mu3 have been characterized, arising from the alternative splicing of the this gene. mu Opioid receptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus, amygdala) and in the peripheral nervous system (myenteric neurons and vas deferens). mu Opioid receptors have been implicated in respiration, cardiovascular functions, feeding, learning and memory, intestinal transit, locomotor activity, thermoregulation, hormone secretion and immune functions. The human gene encoding the mu opioid receptor has been localized to chromosome 6 (6q24-q25).

Gene Wiki entry for OPRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRM1 Gene

Genomics for OPRM1 Gene

Genomic Location for OPRM1 Gene

Start:
154,010,496 bp from pter
End:
154,246,867 bp from pter
Size:
236,372 bases
Orientation:
Plus strand

Genomic View for OPRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRM1 Gene

Regulatory Elements for OPRM1 Gene

Proteins for OPRM1 Gene

  • Protein details for OPRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35372-OPRM_HUMAN
    Recommended name:
    Mu-type opioid receptor
    Protein Accession:
    P35372
    Secondary Accessions:
    • B0FXJ1
    • B2R9S7
    • B8Q1L7
    • B8Q1L8
    • B8Q1L9
    • E7EWZ3
    • G8XRH6
    • G8XRH8
    • Q12930
    • Q4VWM1
    • Q4VWM2
    • Q4VWM3
    • Q4VWM4
    • Q4VWM6
    • Q4VWX6
    • Q5TDA1
    • Q6UPP1
    • Q6UQ80
    • Q7Z2D8
    • Q86V80
    • Q8IWW3
    • Q8IWW4
    • Q9UCZ4
    • Q9UN57

    Protein attributes for OPRM1 Gene

    Size:
    400 amino acids
    Molecular mass:
    44779 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).
    Miscellaneous:
    • OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation
    SequenceCaution:
    • Sequence=CAI20458.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW47705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OPRM1 Gene

Proteomics data for OPRM1 Gene at MOPED

Post-translational modifications for OPRM1 Gene

  • Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by ADRBK1 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn9, Asn12, Asn33, Asn40, and Asn48

No data available for DME Specific Peptides for OPRM1 Gene

Domains for OPRM1 Gene

Gene Families for OPRM1 Gene

HGNC:
  • OPR :GPCR / Class A : Opioid receptors
IUPHAR :

UniProtKB/Swiss-Prot:

OPRM_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P35372
genes like me logo Genes that share domains with OPRM1: view

Function for OPRM1 Gene

Molecular function for OPRM1 Gene

GENATLAS Biochemistry: opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid peptides,also major target for opioid analgesic agents and heroin and a third splice varient acting as a morphine-6 beta-glucuronide receptor,depressing cAMP levels,opening a G protein-modulated K+ channel
UniProtKB/Swiss-Prot Function: Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity

Gene Ontology (GO) - Molecular Function for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 20214800
GO:0004930 G-protein coupled receptor activity ISS --
GO:0004979 beta-endorphin receptor activity IMP 9689128
GO:0004985 opioid receptor activity --
GO:0005245 voltage-gated calcium channel activity ISS --
genes like me logo Genes that share ontologies with OPRM1: view
genes like me logo Genes that share phenotypes with OPRM1: view

Animal Models for OPRM1 Gene

MGI Knock Outs for OPRM1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OPRM1 Gene

Localization for OPRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRM1 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 12: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRM1 Gene COMPARTMENTS Subcellular localization image for OPRM1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 3
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum TAS 9242668
GO:0005794 Golgi apparatus TAS 9242668
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7905839
genes like me logo Genes that share ontologies with OPRM1: view

Pathways for OPRM1 Gene

genes like me logo Genes that share pathways with OPRM1: view

Pathways by source for OPRM1 Gene

Gene Ontology (GO) - Biological Process for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7905839
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with OPRM1: view

Compounds for OPRM1 Gene

(5) Tocris Compounds for OPRM1 Gene

Compound Action Cas Number
beta-Funaltrexamine hydrochloride Irreversible mu-selective antagonist [72786-10-8]
CTAP Selective and potent mu antagonist [103429-32-9]
CTOP Highly selective, potent mu antagonist [103429-31-8]
Cyprodime hydrochloride Selective mu antagonist [118111-54-9]
DAMGO Selective mu agonist [78123-71-4]

(3) HMDB Compounds for OPRM1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Codeine
  • (-)-Codeine
76-57-3
Loperamide
  • Apo-Loperamide
53179-11-6

(40) Drugbank Compounds for OPRM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Methylfentanyl
  • 3-MF
42045-86-3 target agonist
3-Methylthiofentanyl
86052-04-2 target agonist
Alfentanil
  • Alfentanilum [INN-Latin]
71195-58-9 target agonist
Alvimopan
170098-38-1 target antagonist
Anileridine
  • Anileridina [INN-Spanish]
144-14-9 target agonist

(40) IUPHAR Ligand for OPRM1 Gene

Ligand Type Action Affinity Pubmed IDs
nor-binaltorphimine Antagonist Antagonist 11
dynorphin A Agonist Full agonist 10.8
dynorphin A-(1-13) Agonist Full agonist 10.7
(-)-bremazocine Agonist Partial agonist 10.5
buprenorphine Antagonist Antagonist 10.2
(-)-cyclazocine Agonist Partial agonist 10
(-)-EKC Agonist Full agonist 10
dynorphin B Agonist Partial agonist 9.9
dynorphin A-(1-8) Agonist Full agonist 9.9
(-)-quadazocine Antagonist Antagonist 9.7
CTOP Antagonist Antagonist 9.7
etorphine Agonist Full agonist 9.7
beta-FNA Antagonist Antagonist 9.7
diprenorphine Antagonist Antagonist 9.7
dynorphin-(1-11) Agonist Full agonist 9.7
nalmefene Antagonist Antagonist 9.5
naloxone benzoylhydrazone Agonist Partial agonist 9.5
naltrexone Antagonist Antagonist 9.4
nalorphine Agonist Partial agonist 9.1
DADLE Agonist Full agonist 8.7
naloxone Antagonist Antagonist 8.6
CTAP Antagonist Antagonist 8.6
(-)-pentazocine Agonist Partial agonist 8.6
BNTX Antagonist Antagonist 8.4
naltriben Antagonist Antagonist 8.4
endomorphin-1 Agonist Full agonist 8.3
DSLET Agonist Full agonist 8.2
PL017 Agonist Full agonist 8.2
[Leu]enkephalin Agonist Partial agonist 8.1
naltrindole Antagonist Antagonist 8
normorphine Agonist Full agonist 7.8
morphine Agonist Partial agonist 7.3
fentanyl Agonist Partial agonist 7.1
dihydromorphine Agonist Partial agonist 7.1
etonitazene Agonist Partial agonist 6.9
codeine Agonist Full agonist 6.9
DAMGO Agonist Partial agonist 6.5
(-)-methadone Agonist Partial agonist 6.5
[3H]DAMGO Agonist Full agonist
[3H]PL017 Agonist Full agonist

(130) Novoseek inferred chemical compound relationships for OPRM1 Gene

Compound -log(P) Hits PubMed IDs
damgo 93.9 102
morphine 90.5 177
naloxone 88.1 54
alvimopan 87.7 13
etorphine 86.5 5

(13) PharmGKB related drug/compound annotations for OPRM1 Gene

genes like me logo Genes that share compounds with OPRM1: view

Transcripts for OPRM1 Gene

Unigene Clusters for OPRM1 Gene

Opioid receptor, mu 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - -
SP12: -
SP13:
SP14:

Relevant External Links for OPRM1 Gene

GeneLoc Exon Structure for
OPRM1
ECgene alternative splicing isoforms for
OPRM1

Expression for OPRM1 Gene

mRNA expression in normal human tissues for OPRM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRM1 Gene

This gene is overexpressed in Testis (16.4), Brain - Cerebellum (13.1), and Brain - Cerebellar Hemisphere (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OPRM1 Gene

SOURCE GeneReport for Unigene cluster for OPRM1 Gene Hs.2353

mRNA Expression by UniProt/SwissProt for OPRM1 Gene

P35372-OPRM_HUMAN
Tissue specificity: Expressed in brain. Isoform 16 and isoform 17 are detected in brain.
genes like me logo Genes that share expressions with OPRM1: view

Orthologs for OPRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRM1 36
  • 99.25 (n)
  • 99.25 (a)
OPRM1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPRM1 36
  • 90 (n)
  • 92.75 (a)
OPRM1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRM1 36
  • 90.44 (n)
  • 91.97 (a)
mouse
(Mus musculus)
Mammalia Oprm1 36
  • 87.22 (n)
  • 94.3 (a)
Oprm1 16
Oprm1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPRM1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRM1 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprm1 36
  • 87.27 (n)
  • 94.47 (a)
chicken
(Gallus gallus)
Aves OPRM1 36
  • 76.33 (n)
  • 83.78 (a)
OPRM1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRM1 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprm1 36
  • 75.52 (n)
  • 85.03 (a)
zebrafish
(Danio rerio)
Actinopterygii oprm1 36
  • 71.07 (n)
  • 78.44 (a)
oprm1 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AlstR 38
  • 35 (a)
AlCR2 38
  • 36 (a)
Species with no ortholog for OPRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRM1 Gene

ENSEMBL:
Gene Tree for OPRM1 (if available)
TreeFam:
Gene Tree for OPRM1 (if available)

Paralogs for OPRM1 Gene

genes like me logo Genes that share paralogs with OPRM1: view

Variants for OPRM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OPRM1 Gene

P35372-OPRM_HUMAN
Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form

Sequence variations from dbSNP and Humsavar for OPRM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs471512 -- 154,110,720(-) tagta(A/G)agatg intron-variant, downstream-variant-500B
rs474043 -- 154,056,354(-) ATGAG(A/G)TCAAG intron-variant
rs474466 -- 154,045,600(+) GTTTC(A/G)TATCC intron-variant
rs476685 -- 154,056,606(+) TCTTA(C/T)GGTGC intron-variant
rs477292 -- 154,042,252(-) CTTCA(A/G)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRM1 Gene

Variant ID Type Subtype PubMed ID
esv2516727 CNV Insertion 19546169
nsv516084 CNV Loss 19592680
nsv886783 CNV Loss 21882294
nsv527049 CNV Loss 19592680
nsv520558 CNV Loss 19592680
nsv886784 CNV Loss 21882294
esv259847 OTHER Complex 20981092
nsv524944 CNV Loss 19592680
nsv830847 CNV Gain 17160897
esv2482492 CNV Deletion 19546169
esv2085542 CNV Deletion 18987734
esv2944 CNV Deletion 18987735
esv2732936 CNV Deletion 23290073
esv6786 CNV Loss 19470904
esv2658396 CNV Deletion 23128226
nsv349212 CNV Loss 16902084
esv1000500 CNV Deletion 20482838
esv1146800 CNV Deletion 17803354
esv2732937 CNV Deletion 23290073
esv2360629 CNV Deletion 18987734
esv2429923 CNV Deletion 19546169
esv1070898 CNV Deletion 17803354
esv1212073 CNV Insertion 17803354
nsv5550 CNV Insertion 18451855

Relevant External Links for OPRM1 Gene

HapMap Linkage Disequilibrium report
OPRM1
Human Gene Mutation Database (HGMD)
OPRM1

Disorders for OPRM1 Gene

(58) Novoseek inferred disease relationships for OPRM1 Gene

Disease -log(P) Hits PubMed IDs
opioid dependence 73.8 24
heroin addiction 70 6
respiratory depression 64.7 7
hyperalgesia 61.2 4
substance dependence 60.5 15

Relevant External Links for OPRM1

Genetic Association Database (GAD)
OPRM1
Human Genome Epidemiology (HuGE) Navigator
OPRM1
genes like me logo Genes that share disorders with OPRM1: view

No data available for UniProtKB/Swiss-Prot for OPRM1 Gene

Publications for OPRM1 Gene

  1. Mu opioid receptor gene variants: lack of association with alcohol dependence. (PMID: 9399694) Bergen A.W. … Goldman D. (Mol. Psychiatry 1997) 3 4 23 49
  2. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. (PMID: 11933204) Shi J. … Hu G. (Hum. Mutat. 2002) 3 23 25 49
  3. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. (PMID: 16580639) Choi H.S. … Loh H.H. (Biochem. Biophys. Res. Commun. 2006) 3 4 23 25
  4. Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. (PMID: 7905839) Wang J.-B. … Uhl G.R. (FEBS Lett. 1994) 3 4 23
  5. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. (PMID: 9689128) Bond C. … Yu L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23

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