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Aliases for OPRM1 Gene

Aliases for OPRM1 Gene

  • Opioid Receptor Mu 1 2 3
  • Opioid Receptor, Mu 1 2 3 5
  • Mu Opiate Receptor 3 4
  • M-OR-1 3 4
  • MOR1 3 4
  • MOP 3 4
  • Mu Opioid Receptor HMOR-1a 3
  • Mu Opioid Receptor 4
  • MOR-1 4
  • LMOR 3
  • OPRM 3
  • HMOP 4
  • MOR 3

External Ids for OPRM1 Gene

Previous GeneCards Identifiers for OPRM1 Gene

  • GC06P154255
  • GC06P154391
  • GC06P154452
  • GC06P151895

Summaries for OPRM1 Gene

Entrez Gene Summary for OPRM1 Gene

  • This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

GeneCards Summary for OPRM1 Gene

OPRM1 (Opioid Receptor Mu 1) is a Protein Coding gene. Diseases associated with OPRM1 include oprm1-related altered drug metabolism and substance dependence. Among its related pathways are Development Endothelin-1/EDNRA signaling and Circadian entrainment. GO annotations related to this gene include G-protein coupled receptor activity and voltage-gated calcium channel activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRM1 Gene

  • Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.

Tocris Summary for OPRM1 Gene

  • The mu opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and NOP receptors. Three splice variants of the receptor (designated mu1, mu2 and mu3) have been characterized.

Gene Wiki entry for OPRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRM1 Gene

Genomics for OPRM1 Gene

Regulatory Elements for OPRM1 Gene

Enhancers for OPRM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPRM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPRM1 Gene

Chromosome:
6
Start:
154,010,496 bp from pter
End:
154,246,867 bp from pter
Size:
236,372 bases
Orientation:
Plus strand

Genomic View for OPRM1 Gene

Genes around OPRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRM1 Gene

Proteins for OPRM1 Gene

  • Protein details for OPRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35372-OPRM_HUMAN
    Recommended name:
    Mu-type opioid receptor
    Protein Accession:
    P35372
    Secondary Accessions:
    • B0FXJ1
    • B2R9S7
    • B8Q1L7
    • B8Q1L8
    • B8Q1L9
    • E7EWZ3
    • G8XRH6
    • G8XRH8
    • Q12930
    • Q4VWM1
    • Q4VWM2
    • Q4VWM3
    • Q4VWM4
    • Q4VWM6
    • Q4VWX6
    • Q5TDA1
    • Q6UPP1
    • Q6UQ80
    • Q7Z2D8
    • Q86V80
    • Q8IWW3
    • Q8IWW4
    • Q9UCZ4
    • Q9UN57

    Protein attributes for OPRM1 Gene

    Size:
    400 amino acids
    Molecular mass:
    44779 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).
    Miscellaneous:
    • OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation.
    SequenceCaution:
    • Sequence=CAI20458.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW47705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OPRM1 Gene

Proteomics data for OPRM1 Gene at MOPED

Post-translational modifications for OPRM1 Gene

  • Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by ADRBK1 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4 (By similarity).
  • Glycosylation at Asn 9, Asn 12, Asn 33, Asn 40, and Asn 48
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for OPRM1 (mu Opioid R/OPRM1)
  • Cell Signaling Technology (CST) Antibodies for OPRM1 (MOR-1)

No data available for DME Specific Peptides for OPRM1 Gene

Domains & Families for OPRM1 Gene

Gene Families for OPRM1 Gene

Graphical View of Domain Structure for InterPro Entry

P35372

UniProtKB/Swiss-Prot:

OPRM_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRM1: view

Function for OPRM1 Gene

Molecular function for OPRM1 Gene

GENATLAS Biochemistry:
opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid peptides,also major target for opioid analgesic agents and heroin and a third splice varient acting as a morphine-6 beta-glucuronide receptor,depressing cAMP levels,opening a G protein-modulated K+ channel
UniProtKB/Swiss-Prot Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.

Gene Ontology (GO) - Molecular Function for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004979 beta-endorphin receptor activity IEA,IMP 9689128
GO:0008022 protein C-terminus binding IEA --
GO:0031005 filamin binding IEA --
GO:0031681 G-protein beta-subunit binding IBA --
GO:0038047 morphine receptor activity ISS --
genes like me logo Genes that share ontologies with OPRM1: view
genes like me logo Genes that share phenotypes with OPRM1: view

Animal Models for OPRM1 Gene

MGI Knock Outs for OPRM1:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRM1 Gene

Localization for OPRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRM1 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 12: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRM1 Gene COMPARTMENTS Subcellular localization image for OPRM1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 2
chloroplast 1
cytoskeleton 1
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IDA 20214800
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7905839
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with OPRM1: view

Pathways & Interactions for OPRM1 Gene

genes like me logo Genes that share pathways with OPRM1: view

SIGNOR curated interactions for OPRM1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS --
GO:0007268 synaptic transmission IBA --
GO:0007600 sensory perception NAS 9689128
genes like me logo Genes that share ontologies with OPRM1: view

Drugs & Compounds for OPRM1 Gene

(187) Drugs for OPRM1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naltrexone Approved, Investigational Pharma Antagonist, antagonist, Target 367
Methadone Approved Pharma agonist, Target 307
Morphine Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 889
Naloxone Approved Pharma Antagonist, antagonist, Target 233
Fentanyl Approved, Illicit, Investigational Pharma Full agonist, Agonist, agonist, Target 721

(57) Additional Compounds for OPRM1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-EKC
Full agonist, Agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]DAMGO
Full agonist, Agonist
[<sup>3</sup>H]PL017
Full agonist, Agonist
beta-FNA
Antagonist

(5) Tocris Compounds for OPRM1 Gene

Compound Action Cas Number
DAMGO Selective mu agonist 78123-71-4
Endomorphin-1 Potent and selective mu agonist 189388-22-5
Endomorphin-2 Potent and selective mu agonist 141801-26-5
Loperamide hydrochloride Peripherally acting mu agonist; Ca2+ channel blocker 34552-83-5
PL 017 Selective mu agonist 83397-56-2

(8) ApexBio Compounds for OPRM1 Gene

Compound Action Cas Number
Adrenorphin Endogenous μ/κ opioid agonist,potent and selective 88377-68-8
Beta-Lipotropin (1-10), porcine Morphine-like substance 77875-68-4
Endomorphin-1 Agonist of μopioid receptors,highly potent and selective 189388-22-5
Loperamide HCl 34552-83-5
Meptazinol HCl 59263-76-2
Naloxone HCl 357-08-4
Naltrexone HCl 16676-29-2
Trimebutine Antimuscarinic 39133-31-8
genes like me logo Genes that share compounds with OPRM1: view

Drug Products

Transcripts for OPRM1 Gene

mRNA/cDNA for OPRM1 Gene

Unigene Clusters for OPRM1 Gene

Opioid receptor, mu 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - -
SP12: -
SP13:
SP14:

Relevant External Links for OPRM1 Gene

GeneLoc Exon Structure for
OPRM1
ECgene alternative splicing isoforms for
OPRM1

Expression for OPRM1 Gene

mRNA expression in normal human tissues for OPRM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRM1 Gene

This gene is overexpressed in Testis (x16.4), Brain - Cerebellum (x13.1), and Brain - Cerebellar Hemisphere (x8.3).

Protein differential expression in normal tissues from HIPED for OPRM1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPRM1 Gene



SOURCE GeneReport for Unigene cluster for OPRM1 Gene Hs.2353

mRNA Expression by UniProt/SwissProt for OPRM1 Gene

P35372-OPRM_HUMAN
Tissue specificity: Expressed in brain. Isoform 16 and isoform 17 are detected in brain.
genes like me logo Genes that share expression patterns with OPRM1: view

Protein tissue co-expression partners for OPRM1 Gene

- Elite partner

Primer Products

Orthologs for OPRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OPRM1 35
  • 90 (n)
  • 92.75 (a)
OPRM1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRM1 35
  • 90.44 (n)
  • 91.97 (a)
mouse
(Mus musculus)
Mammalia Oprm1 35
  • 87.22 (n)
  • 94.3 (a)
Oprm1 16
Oprm1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OPRM1 35
  • 99.25 (n)
  • 99.25 (a)
OPRM1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprm1 35
  • 87.27 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia OPRM1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRM1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRM1 35
  • 76.33 (n)
  • 83.78 (a)
OPRM1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRM1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprm1 35
  • 75.52 (n)
  • 85.03 (a)
zebrafish
(Danio rerio)
Actinopterygii oprm1 35
  • 71.07 (n)
  • 78.44 (a)
oprm1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 37
  • 36 (a)
AlstR 37
  • 35 (a)
Species with no ortholog for OPRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRM1 Gene

ENSEMBL:
Gene Tree for OPRM1 (if available)
TreeFam:
Gene Tree for OPRM1 (if available)

Paralogs for OPRM1 Gene

genes like me logo Genes that share paralogs with OPRM1: view

Variants for OPRM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OPRM1 Gene

P35372-OPRM_HUMAN
Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form.

Sequence variations from dbSNP and Humsavar for OPRM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1799971 - 154,039,662(+) ATGGC(A/G)ACCTG intron-variant, nc-transcript-variant, reference, missense
rs1799972 - 154,039,561(+) CGCTG(A/C/T)CCCCA intron-variant, nc-transcript-variant, reference, missense
rs17174794 - 154,089,975(+) GATCT(C/G/T)CATAG intron-variant, nc-transcript-variant, reference, missense
rs1799974 - 154,091,087(+) CTTGC(A/G)CCTCA intron-variant, nc-transcript-variant, reference, missense
rs17174801 - 154,089,989(+) ACTAT(A/G)ACATG intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OPRM1 Gene

Variant ID Type Subtype PubMed ID
esv2516727 CNV Insertion 19546169
nsv516084 CNV Loss 19592680
nsv886783 CNV Loss 21882294
nsv527049 CNV Loss 19592680
nsv520558 CNV Loss 19592680
nsv886784 CNV Loss 21882294
esv259847 OTHER Complex 20981092
nsv524944 CNV Loss 19592680
nsv830847 CNV Gain 17160897
esv2482492 CNV Deletion 19546169
esv2085542 CNV Deletion 18987734
esv2944 CNV Deletion 18987735
esv2732936 CNV Deletion 23290073
esv6786 CNV Loss 19470904
esv2658396 CNV Deletion 23128226
nsv349212 CNV Loss 16902084
esv1000500 CNV Deletion 20482838
esv1146800 CNV Deletion 17803354
esv2732937 CNV Deletion 23290073
esv2360629 CNV Deletion 18987734
esv2429923 CNV Deletion 19546169
esv1070898 CNV Deletion 17803354
esv1212073 CNV Insertion 17803354
nsv5550 CNV Insertion 18451855

Variation tolerance for OPRM1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.89; 87.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRM1 Gene

HapMap Linkage Disequilibrium report
OPRM1
Human Gene Mutation Database (HGMD)
OPRM1

Disorders for OPRM1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for OPRM1 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oprm1-related altered drug metabolism
substance dependence
drug dependence
  • substance dependence
pertussis
  • bordetella infection
opiate dependence
  • opioid type dependence
- elite association - COSMIC cancer census association via MalaCards
Search OPRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRM1

Genetic Association Database (GAD)
OPRM1
Human Genome Epidemiology (HuGE) Navigator
OPRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRM1
genes like me logo Genes that share disorders with OPRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRM1 Gene

Publications for OPRM1 Gene

  1. Mu opioid receptor gene variants: lack of association with alcohol dependence. (PMID: 9399694) Bergen A.W. … Goldman D. (Mol. Psychiatry 1997) 3 4 23 48 67
  2. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. (PMID: 16580639) Choi H.S. … Loh H.H. (Biochem. Biophys. Res. Commun. 2006) 3 23 25 26
  3. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. (PMID: 11933204) Shi J. … Hu G. (Hum. Mutat. 2002) 3 23 25 26
  4. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. (PMID: 17487229) Weerts E.M. … McCaul M.E. (Neuropsychopharmacology 2008) 23 25 26
  5. Oral oxymorphone for pain management. (PMID: 17595308) Chamberlin K.W. … Tan J. (Ann Pharmacother 2007) 23 25 26

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