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Aliases for OPRM1 Gene

Aliases for OPRM1 Gene

  • Opioid Receptor Mu 1 2 3 5
  • Mu Opiate Receptor 3 4
  • M-OR-1 3 4
  • MOR1 3 4
  • MOP 3 4
  • Mu Opioid Receptor HMOR-1a 3
  • Mu-Type Opioid Receptor 3
  • Opioid Receptor, Mu 1 2
  • Mu Opioid Receptor 4
  • MOR-1 4
  • LMOR 3
  • OPRM 3
  • HMOP 4
  • MOR 3

External Ids for OPRM1 Gene

Previous GeneCards Identifiers for OPRM1 Gene

  • GC06P154255
  • GC06P154391
  • GC06P154452
  • GC06P151895

Summaries for OPRM1 Gene

Entrez Gene Summary for OPRM1 Gene

  • This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

GeneCards Summary for OPRM1 Gene

OPRM1 (Opioid Receptor Mu 1) is a Protein Coding gene. Diseases associated with OPRM1 include Oprm1-Related Altered Drug Metabolism and Substance Dependence. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and voltage-gated calcium channel activity. An important paralog of this gene is OPRD1.

UniProtKB/Swiss-Prot for OPRM1 Gene

  • Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.

Tocris Summary for OPRM1 Gene

  • The mu opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and NOP receptors. Three splice variants of the receptor (designated mu1, mu2 and mu3) have been characterized.

Gene Wiki entry for OPRM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRM1 Gene

Genomics for OPRM1 Gene

Regulatory Elements for OPRM1 Gene

Enhancers for OPRM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F154039 0.9 ENCODE 11.9 +29.0 29045 0.2 ELF3 ARID4B ZNF48 ZSCAN9 RARA ZNF143 MIXL1 THAP11 ZNF263 KLF11 OPRM1 GC06P154143
GH06F154080 0.7 FANTOM5 10.9 +70.5 70510 0.1 ZNF316 ATF1 ZNF133 MAFG MAFK EMSY ATF2 OPRM1 GC06P154143
GH06F153947 0.6 ENCODE 11 -62.5 -62486 0.1 CTCF TEAD4 ZNF143 TRIM22 RAD21 TEAD3 OPRM1 HMGB3P19
GH06F154125 0.2 Ensembl 5.2 +115.1 115105 0.4 OPRM1 GC06P154143
GH06F154120 0.4 FANTOM5 2.2 +110.2 110154 0.1 YY1 OPRM1 GC06P154143
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OPRM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPRM1 Gene

Chromosome:
6
Start:
154,010,496 bp from pter
End:
154,246,867 bp from pter
Size:
236,372 bases
Orientation:
Plus strand

Genomic View for OPRM1 Gene

Genes around OPRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRM1 Gene

Proteins for OPRM1 Gene

  • Protein details for OPRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35372-OPRM_HUMAN
    Recommended name:
    Mu-type opioid receptor
    Protein Accession:
    P35372
    Secondary Accessions:
    • B0FXJ1
    • B2R9S7
    • B8Q1L7
    • B8Q1L8
    • B8Q1L9
    • E7EWZ3
    • G8XRH6
    • G8XRH8
    • Q12930
    • Q4VWM1
    • Q4VWM2
    • Q4VWM3
    • Q4VWM4
    • Q4VWM6
    • Q4VWX6
    • Q5TDA1
    • Q6UPP1
    • Q6UQ80
    • Q7Z2D8
    • Q86V80
    • Q8IWW3
    • Q8IWW4
    • Q9UCZ4
    • Q9UN57

    Protein attributes for OPRM1 Gene

    Size:
    400 amino acids
    Molecular mass:
    44779 Da
    Quaternary structure:
    • Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).
    Miscellaneous:
    • OPRM1 is the main physiological target for most clinically important opioid analgesics. OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level. Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with cellular excitation.
    SequenceCaution:
    • Sequence=CAI20458.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW47705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OPRM1 Gene

Post-translational modifications for OPRM1 Gene

  • Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4 (By similarity).
  • Glycosylation at Asn 9, Asn 12, Asn 33, Asn 40, and Asn 48
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPRM1 Gene

Domains & Families for OPRM1 Gene

Gene Families for OPRM1 Gene

Graphical View of Domain Structure for InterPro Entry

P35372

UniProtKB/Swiss-Prot:

OPRM_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRM1: view

Function for OPRM1 Gene

Molecular function for OPRM1 Gene

GENATLAS Biochemistry:
opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid peptides,also major target for opioid analgesic agents and heroin and a third splice varient acting as a morphine-6 beta-glucuronide receptor,depressing cAMP levels,opening a G protein-modulated K+ channel
UniProtKB/Swiss-Prot Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.

Gene Ontology (GO) - Molecular Function for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 20214800
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,ISS --
GO:0004979 beta-endorphin receptor activity IEA,IMP 9689128
GO:0004985 opioid receptor activity IEA --
genes like me logo Genes that share ontologies with OPRM1: view
genes like me logo Genes that share phenotypes with OPRM1: view

Animal Models for OPRM1 Gene

MGI Knock Outs for OPRM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for OPRM1

Clone Products

  • Addgene plasmids for OPRM1
  • R&D Systems cDNA Clones for OPRM1 (mu Opioid R/OPRM1)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRM1 Gene

Localization for OPRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRM1 Gene

Cell membrane; Multi-pass membrane protein.
Isoform 12: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPRM1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
endosome 4
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum TAS 9242668
GO:0005794 Golgi apparatus TAS 9242668
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7905839
genes like me logo Genes that share ontologies with OPRM1: view

Pathways & Interactions for OPRM1 Gene

genes like me logo Genes that share pathways with OPRM1: view

SIGNOR curated interactions for OPRM1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for OPRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7905839
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with OPRM1: view

Drugs & Compounds for OPRM1 Gene

(229) Drugs for OPRM1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naltrexone Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target Opioid receptor antagonist 378
Methadone Approved Pharma agonist, Target 319
Morphine Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 960
Naloxone Approved, Vet_approved Pharma Antagonist, antagonist, Target 243
Fentanyl Approved, Illicit, Investigational, Vet_approved Pharma Full agonist, Agonist, agonist, Target 773

(51) Additional Compounds for OPRM1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-Funaltrexamine hydrochloride
72786-10-8
(-)-EKC
Full agonist, Agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]DAMGO
Full agonist, Agonist
[<sup>3</sup>H]PL017
Full agonist, Agonist

(5) Tocris Compounds for OPRM1 Gene

Compound Action Cas Number
beta-Funaltrexamine hydrochloride Irreversible mu-selective antagonist 72786-10-8
CTAP Selective and potent mu antagonist 103429-32-9
CTOP Potent and selective mu antagonist 103429-31-8
Cyprodime hydrochloride Selective mu antagonist 118111-54-9
DAMGO Selective mu agonist 78123-71-4

(61) ApexBio Compounds for OPRM1 Gene

Compound Action Cas Number
[Leu5]-Enkephalin 58822-25-6
Adrenorphin Endogenous μ/κ opioid agonist,potent and selective 88377-68-8
Alvimopan Mu-opioid receptors antagonist 156053-89-3
Alvimopan dihydrate μ-opioid receptor antagonist,peripherally acting 170098-38-1
Alvimopan monohydrate PAM-OR antagonist 1383577-62-5
Beta-Lipotropin (1-10), porcine Morphine-like substance 77875-68-4
BNTX maleate 864461-31-4
BRL 52537 hydrochloride κ/μ opioid receptor agonist,potent and selective 112282-24-3
Buprenorphine hydrochloride 53152-21-9
Clocinnamox mesylate 117332-69-1
CTAP 103429-32-9
CTOP 103429-31-8
Cyprodime hydrochloride 118111-54-9
DADLE 63631-40-3
DAMGO 78123-71-4
Deltorphin I 122752-15-2
DIPPA hydrochloride 155512-52-0
Diprenorphine 14357-78-9
DPDPE 88373-73-3
DSLET 75644-90-5
Dynorphin A 80448-90-4
Dynorphin B 83335-41-5
Endomorphin-1 Agonist of μopioid receptors,highly potent and selective 189388-22-5
Endomorphin-2 141801-26-5
Fentanyl citrate 990-73-8
FIT 85951-63-9
GNTI dihydrochloride 351183-88-5
GR 89696 fumarate 126766-32-3
ICI 154,129 83420-94-4
ICI 174,864 89352-67-0
ICI 199,441 hydrochloride 115199-84-3
ICI 204,448 hydrochloride 121264-04-8
JDTic Opioid antagonist 361444-66-8
Loperamide HCl 34552-83-5
Meptazinol HCl 59263-76-2
Methylnaltrexone Bromide Antagonist of peripherally acting μ-opioid 73232-52-7
ML 190 1355244-02-8
Morphine hydrochloride 52-26-6
Nalmefene - d3 55096-26-9
Nalmefene hydrochloride 58895-64-0
Naloxonazine dihydrochloride 880759-65-9
Naloxone benzoylhydrazone 119630-94-3
Naloxone HCl 357-08-4
Naltrexone Opioid receptor antagonist 16590-41-3
Naltrexone HCl 16676-29-2
Naltriben mesylate 122517-78-6
Naltrindole hydrochloride 111469-81-9
N-Benzylnaltrindole hydrochloride 1206487-81-1
N-MPPP Hydrochloride 207452-97-9
nor-Binaltorphimine dihydrochloride 113158-34-2
Oxycodone hydrochloride 124-90-3
Oxymorphone 76-41-5
PL 017 83397-56-2
Salvinorin A 83729-01-5
SB 205607 dihydrobromide 1217628-73-3
SDM25N hydrochloride 342884-71-3
SNC 162 178803-51-5
SNC 80 156727-74-1
Trimebutine Antimuscarinic 39133-31-8
U-54494A hydrochloride 112465-94-8
β-Funaltrexamine hydrochloride 72786-10-8
genes like me logo Genes that share compounds with OPRM1: view

Drug Products

Transcripts for OPRM1 Gene

mRNA/cDNA for OPRM1 Gene

Unigene Clusters for OPRM1 Gene

Opioid receptor, mu 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for OPRM1
  • R&D Systems cDNA Clones for OPRM1 (mu Opioid R/OPRM1)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - -
SP12: -
SP13:
SP14:

Relevant External Links for OPRM1 Gene

GeneLoc Exon Structure for
OPRM1
ECgene alternative splicing isoforms for
OPRM1

Expression for OPRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OPRM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRM1 Gene

This gene is overexpressed in Testis (x16.4), Brain - Cerebellum (x13.1), and Brain - Cerebellar Hemisphere (x8.3).

Protein differential expression in normal tissues from HIPED for OPRM1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPRM1 Gene



Protein tissue co-expression partners for OPRM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OPRM1 Gene:

OPRM1

SOURCE GeneReport for Unigene cluster for OPRM1 Gene:

Hs.2353

mRNA Expression by UniProt/SwissProt for OPRM1 Gene:

P35372-OPRM_HUMAN
Tissue specificity: Expressed in brain. Isoform 16 and isoform 17 are detected in brain.
genes like me logo Genes that share expression patterns with OPRM1: view

Primer Products

Orthologs for OPRM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRM1 34 35
  • 99.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OPRM1 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPRM1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRM1 34
  • 90.44 (n)
cow
(Bos Taurus)
Mammalia OPRM1 34 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Oprm1 34
  • 87.27 (n)
mouse
(Mus musculus)
Mammalia Oprm1 34 16 35
  • 87.22 (n)
chicken
(Gallus gallus)
Aves OPRM1 34 35
  • 76.33 (n)
lizard
(Anolis carolinensis)
Reptilia OPRM1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprm1 34
  • 75.52 (n)
zebrafish
(Danio rerio)
Actinopterygii oprm1 34 35
  • 71.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36
  • 36 (a)
AlstR 36
  • 35 (a)
Species where no ortholog for OPRM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRM1 Gene

ENSEMBL:
Gene Tree for OPRM1 (if available)
TreeFam:
Gene Tree for OPRM1 (if available)

Paralogs for OPRM1 Gene

Variants for OPRM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OPRM1 Gene

OPRM_HUMAN-P35372
Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form.

Sequence variations from dbSNP and Humsavar for OPRM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1799971 drug-response 154,039,662(+) ATGGC(A/G)ACCTG intron-variant, nc-transcript-variant, reference, missense
rs17174794 Benign 154,089,975(+) GATCT(C/G)CATAG intron-variant, nc-transcript-variant, reference, missense
rs1012912 -- 154,189,892(+) tgagc(C/T)gagaa intron-variant
rs1016687 -- 154,147,725(+) ccaaa(G/T)gaact intron-variant
rs10223804 -- 154,141,257(+) CACCC(A/G)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRM1 Gene

Variant ID Type Subtype PubMed ID
nsv956517 CNV deletion 24416366
nsv830847 CNV gain 17160897
nsv5550 CNV insertion 18451855
nsv527049 CNV loss 19592680
nsv524944 CNV loss 19592680
nsv520558 CNV loss 19592680
nsv516084 CNV loss 19592680
nsv349212 CNV deletion 16902084
nsv1149344 CNV deletion 26484159
nsv1143164 CNV tandem duplication 24896259
nsv1140715 CNV deletion 24896259
nsv1140714 CNV deletion 24896259
nsv1140196 CNV insertion 24896259
nsv1137164 CNV deletion 24896259
nsv1124133 CNV deletion 24896259
nsv1120159 OTHER inversion 24896259
nsv1074435 CNV deletion 25765185
esv6786 CNV loss 19470904
esv6685 OTHER inversion 19470904
esv3611310 CNV loss 21293372
esv3540682 CNV deletion 23714750
esv3540681 CNV deletion 23714750
esv3540680 CNV deletion 23714750
esv3395425 CNV insertion 20981092
esv3302873 CNV tandem duplication 20981092
esv3282940 CNV deletion 24192839
esv3093456 CNV deletion 24192839
esv2944 CNV loss 18987735
esv2732937 CNV deletion 23290073
esv2732936 CNV deletion 23290073
esv2658396 CNV deletion 23128226
esv2516727 CNV insertion 19546169
esv2482492 CNV deletion 19546169
esv2429923 CNV deletion 19546169
esv2360629 CNV deletion 18987734
esv2085542 CNV deletion 18987734
esv1212073 CNV insertion 17803354
esv1146800 CNV deletion 17803354
esv1070898 CNV deletion 17803354
esv1000500 CNV deletion 20482838
dgv3417n106 CNV deletion 24896259

Variation tolerance for OPRM1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.89; 87.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRM1 Gene

Human Gene Mutation Database (HGMD)
OPRM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPRM1

Disorders for OPRM1 Gene

MalaCards: The human disease database

(27) MalaCards diseases for OPRM1 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search OPRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRM1

Genetic Association Database (GAD)
OPRM1
Human Genome Epidemiology (HuGE) Navigator
OPRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRM1
genes like me logo Genes that share disorders with OPRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRM1 Gene

Publications for OPRM1 Gene

  1. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. (PMID: 16580639) Choi H.S. … Loh H.H. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 25 64
  2. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. (PMID: 11933204) Shi J. … Hu G. (Hum. Mutat. 2002) 3 22 25 46 64
  3. Mu opioid receptor gene variants: lack of association with alcohol dependence. (PMID: 9399694) Bergen A.W. … Goldman D. (Mol. Psychiatry 1997) 3 4 22 46 64
  4. Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. (PMID: 19891732) Deb I. … Das S. (J. Neurochem. 2010) 3 22 46 64
  5. A118G polymorphism of OPRM1 gene is associated with schizophrenia. (PMID: 20112002) SerA1 O. … St'astnA1 F. (J. Mol. Neurosci. 2010) 3 22 46 64

Products for OPRM1 Gene

Sources for OPRM1 Gene

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