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OPRM1 Gene

protein-coding   GIFtS: 68
GCID: GC06P154391

Opioid Receptor, Mu 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opioid Receptor, Mu 11 2     OPRM2
Mu Opiate Receptor2 3     Mu Opioid Receptor HMOR-1a2
M-OR-12 3     Mu-Type Opioid Receptor2
MOP2 3     MOR-13
MOR12 3     hMOP3
LMOR2     Mu Opioid Receptor3
MOR2     

External Ids:    HGNC: 81561   Entrez Gene: 49882   Ensembl: ENSG000001120387   OMIM: 6000185   UniProtKB: P353723   

Export aliases for OPRM1 gene to outside databases

Previous GC identifers: GC06P153921 GC06P154255 GC06P154452 GC06P151895


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPRM1 Gene:
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the
principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and
enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine,
and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated
with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is
conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the
canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of
this gene have only 6 transmembrane domains. (provided by RefSeq, Oct 2013)

GeneCards Summary for OPRM1 Gene:
OPRM1 (opioid receptor, mu 1) is a protein-coding gene. Diseases associated with OPRM1 include opioid abuse, and histrionic personality disorder. GO annotations related to this gene include G-protein alpha-subunit binding and G-protein coupled receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372
Function: Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and
synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist
binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent
exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the
free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The
agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G
alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis
toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses,
including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of
inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC),
phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also
couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and
subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members
of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term
receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the
G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis
via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a
G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor
phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or
near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the
agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid
desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis.
Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties.
Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects.
Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1
isoforms and reduce their ligand binding activity

summary for OPRM1 Gene:
The mu opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled
receptors that also includes kappa, delta and NOP receptors. Three variants of the receptor designated mu1,
mu2 and mu3 have been characterized, arising from the alternative splicing of the this gene. mu Opioid
receptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus,
amygdala) and in the peripheral nervous system (myenteric neurons and vas deferens). mu Opioid receptors
have been implicated in respiration, cardiovascular functions, feeding, learning and memory, intestinal
transit, locomotor activity, thermoregulation, hormone secretion and immune functions. The human gene
encoding the mu opioid receptor has been localized to chromosome 6 (6q24-q25).

Gene Wiki entry for OPRM1 (Mu Opioid receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPRM1 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRM1 promoter sequence
   Search Chromatin IP Primers for OPRM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPRM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24-q25   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q24-q25

OPRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P154391:  view genomic region     (about GC identifiers)

Start:
154,331,631 bp from pter      End:
154,568,001 bp from pter
Size:
236,371 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 (See protein sequence)
Recommended Name: Mu-type opioid receptor  
Size: 400 amino acids; 44779 Da
Subunit: Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A,
SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with PPL; the interaction disrupts agonist-mediated
G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the
interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated
G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS. Interacts with GPM6A, RTP4, SYP, GNAS, RGS9,
RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity)
Miscellaneous: OPRM1 is the main physiological target for most clinically important opioid analgesics.
OPRM1-mediated inhibition of voltage-gated calcium channels on central presynaptic terminals of primary afferent
nociceptors is thought to be one of the primary mechanisms mediating analgesia at the spinal level.
Opioid-induced hyperalgesic responses are observed following both acute and chronic dosing associated with
cellular excitation
Sequence caution: Sequence=CAI20458.1; Type=Erroneous initiation; Sequence=EAW47705.1; Type=Erroneous initiation;
Secondary accessions: B0FXJ1 B2R9S7 B8Q1L7 B8Q1L8 B8Q1L9 E7EWZ3 G8XRH6 G8XRH8 Q12930 Q4VWM1
Q4VWM2 Q4VWM3 Q4VWM4 Q4VWM6 Q4VWX6 Q5TDA1 Q6UPP1 Q6UQ80 Q7Z2D8 Q86V80 Q8IWW3 Q8IWW4 Q9UCZ4
Q9UN57
Alternative splicing: 18 isoforms:  P35372-1   P35372-2   P35372-3   P35372-4   P35372-5   P35372-6   P35372-7   P35372-8   
P35372-9   P35372-10   P35372-11   P35372-12   P35372-13   P35372-14   P35372-15   P35372-16   
P35372-17   P35372-18   (Ref.5 (AAQ77392) sequence differs from that shown due to a polymorphism leading to premature termination of translation (position: 411:Q->Stop))

Explore the universe of human proteins at neXtProt for OPRM1: NX_P35372

Explore proteomics data for OPRM1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated
    phosphorylation modulates receptor internalization. Phosphorylated by ADRBK1 in a agonist-dependent manner.
    Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src
    and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on
    tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor
    down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent
    activation of the ERK pathway (By similarity)1
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon
    formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4
    (By similarity)1
  • Glycosylation2 at Asn9, Asn12, Asn33, Asn40, Asn48
  • Modification sites at PhosphoSitePlus

  • See OPRM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (19 alternative transcripts): 
    NP_000905.3  NP_001008503.2  NP_001008504.2  NP_001008505.2  NP_001138751.1  NP_001138752.1  NP_001138753.1  NP_001138754.1  
    NP_001138755.1  NP_001138756.1  NP_001138757.1  NP_001138758.1  NP_001138759.1  NP_001272451.1  NP_001272452.1  NP_001272453.1  
    NP_001272455.1  NP_001272456.1  NP_001272457.1  

    ENSEMBL proteins: 
     ENSP00000430247   ENSP00000394624   ENSP00000430876   ENSP00000430260   ENSP00000328264  
     ENSP00000411903   ENSP00000410497   ENSP00000428018   ENSP00000430575   ENSP00000229768  
     ENSP00000403549   ENSP00000430097   ENSP00000431048   ENSP00000399359   ENSP00000413752  
     ENSP00000338381   ENSP00000429719   ENSP00000429373   ENSP00000353598  
    Reactome Protein details: P35372

    OPRM1 Human Recombinant Protein Products:

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    OPRM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OPRM1
    R&D Systems Antibodies for OPRM1 (mu Opioid R/OPMR1)
    Cell Signaling Technology (CST) Antibodies for OPRM1  (MOR-1)
    OriGene Antibodies for OPRM1
    OriGene Custom Antibody Services for OPRM1
    Novus Biologicals OPRM1 Antibodies
    Abcam antibodies for OPRM1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for OPRM1
    LSBio Antibodies in human, mouse, rat for OPRM1

    OPRM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OPRM1
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    GenScript OPRM1-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPR: GPCR / Class A : Opioid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: mu receptor
    Opioid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001418 Opioid_rcpt
     IPR000105 Mu_opioid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P35372

    ProtoNet protein and cluster: P35372

    2 Blocks protein domains:
    IPB000105 Mu opioid receptor signature
    IPB001418 Opioid receptor signature


    UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OPRM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRM_HUMAN, P35372
    Function: Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and
    synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist
    binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent
    exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the
    free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The
    agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G
    alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis
    toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses,
    including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of
    inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC),
    phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also
    couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and
    subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members
    of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term
    receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the
    G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis
    via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a
    G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor
    phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or
    near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the
    agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid
    desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis.
    Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties.
    Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects.
    Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1
    isoforms and reduce their ligand binding activity

         Genatlas biochemistry entry for OPRM1:
    opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced
    isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid peptides,also
    major target for opioid analgesic agents and heroin and a third splice varient acting as a morphine-6
    beta-glucuronide receptor,depressing cAMP levels,opening a G protein-modulated K+ channel

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IDA--
    GO:0004930G-protein coupled receptor activity ISS--
    GO:0004979beta-endorphin receptor activity IMP9689128
    GO:0004985opioid receptor activity ----
    GO:0005245voltage-gated calcium channel activity ISS--
         
    OPRM1 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 14 alleles(MGI details for Oprm1):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  no phenotypic analysis  normal  reproductive system 

    OPRM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OPRM1: Oprm1tm1Yxp Oprm1tm1Loh Oprm1tm1Lyu Oprm1tm1Kff Oprm1tm1Jep Oprm1tm1Uhl
                                                         Oprm1tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPRM1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPRM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPRM1

    miRNA
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    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidOPRM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OPRM1

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    GenScript: all cDNA clones in your preferred vector (see all 13): OPRM1 (NM_001008503)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPRM_HUMAN, P35372: Cell membrane; Multi-pass membrane protein
    OPRM_HUMAN, P35372: Isoform 12: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    golgi apparatus4
    nucleus3
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9242668
    GO:0005794Golgi apparatus TAS9242668
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7905839
    GO:0016020membrane ----

    OPRM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPRM1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4ADP signalling through P2Y purinoceptor 12
    G-protein activation0.74
    5Ca-dependent events
    Opioid Signalling0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for OPRM1
        Neuroscience

    4 BioSystems Pathways for OPRM1
        TCR Signaling Pathway
    GPCRs, Class A Rhodopsin-like
    IL4-mediated signaling events
    Peptide GPCRs

    4 Reactome Pathways for OPRM1
        Peptide ligand-binding receptors
    G-protein activation
    G alpha (i) signalling events
    Opioid Signalling


    3 Kegg Pathways  (Kegg details for OPRM1):
        Neuroactive ligand-receptor interaction
    Estrogen signaling pathway
    Morphine addiction


    OPRM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRM1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OPRM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OPRM1 (P353721, 3 ENSP000003946244) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    FLNAP213331, 3, ENSP000003588664EBI-2624570,EBI-350432 I2D: score=1 STRING: ENSP00000358866
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7905839
    GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway IEA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity ISS--

    OPRM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Enzo Life Sciences drugs & compounds for OPRM1
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    Compounds for OPRM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CTOP Highly selective, potent mu antagonist [103429-31-8]
    Cyprodime hydrochlorideSelective mu antagonist[118111-54-9]
    DAMGOSelective mu agonist[78123-71-4]
    CTAPSelective and potent mu antagonist[103429-32-9]
    beta-Funaltrexamine hydrochlorideIrreversible mu-selective antagonist[72786-10-8]

    3 HMDB Compounds for OPRM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Codeine(-)-Codeine (see all 9)76-57-3--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    Selected DrugBank Compounds for OPRM1 (see all 40)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nalbuphine-- 20594-83-6targetantagonist16517095 10844102 15602503 18425947 17407276 9084061 18810678 8388112 19403853 9399970
    ButorphanolButorfanol (see all 4)58786-99-5targetpartial antagonist7705457 12127012 12470863 10381785 17909753 8746803 15942128 8968334 9399970
    NaloxoneEN 1530 Base (see all 7)465-65-6targetantagonist18354714 12842269 11752352 12799988 12566163 12887410 12909198 17918759 17367258
    Tramadol-- 27203-92-5targetagonist8955860 15509185 17380034 11752352 1309873 10961373 10991912 16793069
    3-Methylthiofentanyl-- 86052-04-2targetagonist16797997 16376082 15589524 11752352 19403616 16114980 16332149
    FentanylFentanila [INN-Spanish] (see all 3)437-38-7targetagonist16797997 16376082 15589524 11752352 19403616 16114980 16332149
    HydrocodoneDihydrocodeinone (see all 7)125-29-1targetagonist20665209 16291875 18606504 11752352 14600248 2849950 10640321
    Naltrexone-- 16590-41-3targetantagonist18354714 17487229 11752352 9673788 19068776 17661275 17918759
    PropoxypheneD-Propoxyphene (see all 5)469-62-5targetagonist7562497 10690289 19604717 6249436 11752352 10379623 9399970
    Remifentanil-- 132875-61-7targetagonist9103501 11752352 8875131 8694317 16114980 16332149 9066316

    Selected IUPHAR Ligands for OPRM1 (mu receptor) (see all 40)    About this table
    LigandTypeActionAffinityPubmed IDs
    (-)-cyclazocine
    AgonistPartial agonist109686407
    (-)-quadazocine
    AntagonistAntagonist109686407
    CTOP
    AntagonistAntagonist9.78114680
    (-)-bremazocine
    AntagonistAntagonist9.79686407
    naltrexone
    AntagonistAntagonist9.79686407
    etonitazene
    AgonistFull agonist9.79686407
    (-)-EKC
    AgonistFull agonist9.59686407
    etorphine
    AgonistFull agonist9.59686407
    beta-FNA
    AntagonistAntagonist9.59686407
    nalmefene
    AntagonistAntagonist9.59686407

    Selected Novoseek inferred chemical compound relationships for OPRM1 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    damgo 93.9 126 16682505 (7), 10617147 (4), 9544801 (4), 14743438 (2) (see all 77)
    morphine 90.5 366 16682505 (7), 15504181 (6), 10688980 (6), 11118335 (5) (see all 99)
    naloxone 88.1 61 9605673 (2), 9415708 (2), 9106259 (1), 9282948 (1) (see all 52)
    alvimopan 87.7 14 17340127 (2), 12431026 (1), 15772912 (1), 17042776 (1) (see all 12)
    etorphine 86.5 6 9852117 (2), 18358497 (1), 8618916 (1), 9350996 (1)
    beta funaltrexamine 86.5 58 7805771 (3), 1364844 (2), 9862398 (2), 11500514 (2) (see all 30)
    opiate 85.6 93 9153634 (4), 18181266 (2), 19103668 (2), 10393893 (2) (see all 63)
    [3h]diprenorphine 85.4 9 7805771 (1), 12905615 (1), 15857313 (1), 11076532 (1) (see all 7)
    naltrexone 81.9 62 17768272 (3), 16899031 (2), 18028530 (2), 17374034 (2) (see all 37)
    dpdpe 78.8 10 7925596 (1), 11165441 (1), 8386968 (1), 8947072 (1) (see all 10)

    9 PharmGKB related drug/compound annotations for OPRM1 gene    About this table
    Drug/compound PharmGKB Annotation
    Drugs used in nicotine dependenceCA  
    ethanolCA  
    heroinCA  
    methadoneCA  
    morphineCA  
    naloxoneCA  
    naltrexoneCA  
    nicotineCA  
    opioidsCA  



    OPRM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for OPRM1 gene (19 alternative transcripts): 
    NM_000914.4  NM_001008503.2  NM_001008504.3  NM_001008505.2  NM_001145279.3  NM_001145280.3  NM_001145281.2  NM_001145282.2  
    NM_001145283.2  NM_001145284.3  NM_001145285.2  NM_001145286.2  NM_001145287.2  NM_001285522.1  NM_001285523.1  NM_001285524.1  
    NM_001285526.1  NM_001285527.1  NM_001285528.1  

    Unigene Cluster for OPRM1:

    Opioid receptor, mu 1
    Hs.2353  [show with all ESTs]
    Unigene Representative Sequence: NM_001145287
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000520282 ENST00000434900(uc011efb.2) ENST00000520708 ENST00000518759
    ENST00000330432(uc011efd.2 uc011efe.2 uc011efc.1 uc003qpr.2 uc003qps.2)
    ENST00000428397(uc003qpn.2) ENST00000523520 ENST00000452687 ENST00000522739
    ENST00000524150 ENST00000229768(uc003qpo.1) ENST00000419506(uc011eff.1)
    ENST00000524163 ENST00000519083(uc003qpp.2) ENST00000414028(uc011efi.2)
    ENST00000435918(uc011efh.1) ENST00000337049 ENST00000519613
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OPRM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OPRM1 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b hsa-let-7f
    SwitchGear 3'UTR luciferase reporter plasmidOPRM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OPRM1
    Predesigned siRNA for gene silencing in human, mouse, rat OPRM1
    Clone
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    OriGene clones in human, mouse for OPRM1 (see all 58)
    OriGene ORF clones in mouse, rat for OPRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): OPRM1 (NM_001008503)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRM1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OPRM1
    OriGene qSTAR qPCR primer pairs in human, mouse for OPRM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OPRM1
      QuantiTect SYBR Green Assays in human, mouse, rat OPRM1
      QuantiFast Probe-based Assays in human, mouse, rat OPRM1

    Additional mRNA sequence: 

    AK309655.1 AK313901.1 AY036622.1 AY036623.1 AY195733.2 AY225404.1 AY309001.1 AY309005.1 
    AY309006.1 AY309007.1 AY309008.1 AY364230.1 AY364890.1 AY521028.1 BC074927.2 DQ680044.1 
    EF666090.1 EU340241.1 EU340242.1 EU340243.1 EU360599.2 EU362990.2 FJ041290.1 FJ041291.1 
    FJ041292.1 FJ041293.1 FJ041294.1 GQ258059.1 HQ699462.1 JX914655.1 L25119.1 L29301.1 
    U12569.1 

    4 DOTS entries:

    DT.306401  DT.100690305  DT.92414497  DT.102820783 

    12 AceView cDNA sequences:

    AY036623 BC074927 AY364890 AY364230 AY521028 NM_000914 AY036622 AY195733 
    U12569 L25119 BP346782 L29301 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                      -     -                 -     -     -     -           -     -     -     -     -                     
    SP2:                                      -     -                 -     -     -     -           -     -                                       
    SP3:                                      -     -                 -     -     -     -     -     -     -     -     -     -                     
    SP4:                                      -     -                 -     -     -     -     -     -     -     -     -                           
    SP5:                                      -     -                 -     -     -     -     -     -     -     -     -     -     -     -         


    ECgene alternative splicing isoforms for OPRM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OPRM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCCTAAAA
    OPRM1 Expression
    About this image


    OPRM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Testis (Reproductive System)
    OPRM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPRM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2353

    UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372
    Tissue specificity: Expressed in brain. Isoform 16 and isoform 17 are detected in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRM1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for OPRM1
    OriGene qSTAR qPCR primer pairs in human, mouse for OPRM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OPRM1
    QuantiTect SYBR Green Assays in human, mouse, rat OPRM1
    QuantiFast Probe-based Assays in human, mouse, rat OPRM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPRM1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oprm11 , 5 opioid receptor, mu 11, 5 87.22(n)1
    94.3(a)1
      10 (1.85 cM)5
    183901  NM_001039652.11  NP_001034741.11 
     67585065 
    chicken
    (Gallus gallus)
    Aves OPRM11 opioid receptor, mu 1 76.33(n)
    83.78(a)
      421644  XM_003640960.2  XP_003641008.2 
    lizard
    (Anolis carolinensis)
    Reptilia OPRM16
    opioid receptor, mu 1
    83(a)
    1 ↔ 1
    1(215254058-215276884)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oprm11 opioid receptor, mu 1 75.52(n)
    85.03(a)
      100487937  XM_002933863.2  XP_002933909.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oprm12 opioid receptor, mu 1 76.21(n)   65088  AF132813.1 


    ENSEMBL Gene Tree for OPRM1 (if available)
    TreeFam Gene Tree for OPRM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPRM1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  NPBWR22  
    Selected SIMAP similar genes for OPRM1 using alignment to 17 protein entries:     OPRM_HUMAN (see all proteins) (see all similar genes):
    OPRMI    OPRD1    OPRK1    OPRL1    SSTR4    CX3CR1
    CCR3    CHRM2    SSTR2    NPBWR2    SSTR5    SSTR1
    SSTR3    NPBWR1    GHSR    CXCR2    GPR18    P2RY4

    OPRM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    OPRM_HUMAN, P35372: Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids
    tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3
    times more tightly than the most common allelic form


    Selected SNPs for OPRM1 (see all 5194)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012450811,2
    Cuntested1154410855(+) TTGATC/TGATAC 26 R * stg10--------
    rs17999711,2,,4
    C,F,O,A,Hunknown1154360479(+) ATGGCA/GACCTG 22 N D mis1 int136Minor allele frequency- G:0.24EA MN NS NA EU 6650
    rs341678571,2
    C--151983098(+) TTCCTG/-ACTGT 11 -- int11Minor allele frequency- -:0.50CSA 2
    rs717257071,2
    C--151984159(+) GAGCG-/GAAGAGA 11 -- int10--------
    rs106573501,2
    C--151984850(+) ATGAT-/TGAT  
            
    ATATA
    11 -- int10--------
    rs674478381,2
    C--151984851(+) CATAT-/TGAT  
            
    GATAT
    11 -- int10--------
    rs30708361,2
    C--152011489(+) AAAAA-/AA/AAA
            
    GTGCC
    2 -- int1 cds1 trp30--------
    rs766383171,2
    F--152013773(+) CCTGGC/TGCTGG 1 -- int11Minor allele frequency- T:0.50NA 4
    rs673876511,2
    C--152014453(+) TACTA-/TCTC  
            
    TATCT
    1 -- int10--------
    rs2015115871,2
    C--152014456(+) TATCTA/CTATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for OPRM1 (154331631 - 154568001 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OPRM1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2944CNV Deletion18987735
    esv1146800CNV Deletion17803354
    esv2732937CNV Deletion23290073
    esv2732936CNV Deletion23290073
    esv1070898CNV Deletion17803354
    esv2360629CNV Deletion18987734
    esv2658396CNV Deletion23128226
    esv2429923CNV Deletion19546169
    esv2482492CNV Deletion19546169
    esv1000500CNV Deletion20482838

    Human Gene Mutation Database (HGMD): OPRM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPRM1
    DNA2.0 Custom Variant and Variant Library Synthesis for OPRM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600018    OMIM disorders: --

    Selected diseases for OPRM1 (see all 86):    
    About MalaCards
    opioid abuse    histrionic personality disorder    complex partial epilepsy    neonatal abstinence syndrome
    heroin dependence    substance dependence    familial hemiplegic migraine    hemiplegic migraine
    cocaine dependence    shipyard eye    drug dependence    morphine dependence
    somatoform disorder    opiate dependence    drug addiction    alcohol abuse
    ileus    back pain    chronic pain    endometriosis

    9 diseases from the University of Copenhagen DISEASES database for OPRM1:
    Pain agnosia     Opiate dependence     Alcohol dependence     Withdrawal disorder
    Ileus     Constipation     Shipyard eye     Substance abuse
    Neuroblastoma

    OPRM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for OPRM1 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    opioid dependence 73.8 26 12960749 (5), 17416470 (5), 15558714 (3), 12648891 (2) (see all 12)
    heroin addiction 70 6 18518925 (1), 10911931 (1), 16682632 (1), 17416470 (1) (see all 6)
    respiratory depression 64.7 8 15731588 (2), 17922561 (1), 19461299 (1), 16029065 (1) (see all 6)
    hyperalgesia 61.2 4 14504663 (1), 20357116 (1), 12750434 (1), 19590003 (1)
    substance dependence 60.5 18 12815747 (4), 16476706 (2), 16451620 (1), 12960749 (1) (see all 11)
    alcoholism 56.5 47 17979515 (4), 15902904 (3), 9884158 (3), 16476706 (2) (see all 28)
    drug dependence 53.7 10 9756053 (2), 16476706 (1), 9399694 (1), 19430912 (1) (see all 7)
    dependence psychological 52.8 1 11316510 (1)
    drug addiction 48.7 4 11067846 (1), 16046395 (1), 11506703 (1), 20196742 (1)
    cocaine addiction 40 1 11458541 (1)

    Genetic Association Database (GAD): OPRM1
    Human Genome Epidemiology (HuGE) Navigator: OPRM1 (158 documents)

    Export disorders for OPRM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPRM1 gene, integrated from 10 sources (see all 1226):
    (articles sorted by number of sources associating them with OPRM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mu opioid receptor gene variants: lack of association with alcohol dependence. (PubMed id 9399694)1, 2, 4, 9 Bergen A.W.... Goldman D. (Mol. Psychiatry 1997)
    2. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. (PubMed id 11933204)1, 4, 7, 9 Shi J....Hu G. (Hum. Mutat. 2002)
    3. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. (PubMed id 16580639)1, 2, 7, 9 Choi H.S.... Loh H.H. (Biochem. Biophys. Res. Commun. 2006)
    4. Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking. (PubMed id 14573758)1, 2, 9 Onoprishvili I.... Simon E.J. (Mol. Pharmacol. 2003)
    5. Polymorphism of mu-opioid receptor gene (OPRM1:c.118A&gt;G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. (PubMed id 15731588)1, 4, 9 Romberg R.R....Dahan A. (Anesthesiology 2005)
    6. Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. (PubMed id 18540916)1, 4, 9 Filbey F.M....Hutchison K.E. (Alcohol. Clin. Exp. Res. 2008)
    7. Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. (PubMed id 17416470)1, 4, 9 Glatt S.J....Tsuang M.T. (Drug Alcohol Depend 2007)
    8. A genetic association study of the mu opioid receptor and severe opioid dependence. (PubMed id 12960749)1, 4, 9 Crowley J.J....Grice D.E. (Psychiatr. Genet. 2003)
    9. A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor. (PubMed id 16542645)1, 2, 9 Ancevska-Taneva N....Simon E.J. (Brain Res. 2006)
    10. Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. (PubMed id 15558714)1, 4, 9 Smith R.J....Berrettini W.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4988 HGNC: 8156 AceView: OPRM1 Ensembl:ENSG00000112038 euGenes: HUgn4988
    ECgene: OPRM1 Kegg: 4988 H-InvDB: OPRM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OPRM1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Mu_opioid_receptor
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oprm1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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