Aliases for OPRL1 Gene
External Ids for OPRL1 Gene
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for OPRL1 Gene
OPRL1 (Opiate Receptor-Like 1) is a Protein Coding gene. Diseases associated with OPRL1 include drug dependence and pain agnosia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and nociceptin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for OPRL1 Gene
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord. The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).