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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPRL1 Gene

protein-coding   GIFtS: 65
GCID: GC20P062711

Opiate Receptor-Like 1

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Opiate Receptor-Like 11 2     OOR2 3
Orphanin FQ Receptor1 2 3     ORL12 3
Kappa3-Related Opioid Receptor1 2     LC132 Receptor-Like1
Kappa-Type 3 Opioid Receptor2 3     NOCIR2
KOR-32 3     Nociceptin Receptor2

External Ids:    HGNC: 81551   Entrez Gene: 49872   Ensembl: ENSG000001255107   OMIM: 6025485   UniProtKB: P411463   

Export aliases for OPRL1 gene to outside databases

Previous GC identifers: GC20P062600 GC20P063390 GC20P063437 GC20P062181 GC20P059457


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OPRL1 Gene:
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by
phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide
nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly
instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene,
regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for OPRL1 Gene: 
OPRL1 (opiate receptor-like 1) is a protein-coding gene. Diseases associated with OPRL1 include drug dependence, and neurogenic bladder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include nociceptin receptor activity and G-protein coupled receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146
Function: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of
brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G
proteins which inhibits adenylyl cyclase

summary for OPRL1 Gene:
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of
G-protein-coupled receptors that also includes kappa, delta and mu receptors. NOP receptor mRNA is found in
high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala,
central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and
spinal cord. The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor
and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression
and autonomic control of physiological processes. The human gene encoding the NOP receptor has been
localized to chromosome 20 (20q13.33).

Gene Wiki entry for OPRL1 (Nociceptin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPRL1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OPRL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

OPRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062711:  view genomic region     (about GC identifiers)

Start:
62,711,471 bp from pter      End:
62,731,996 bp from pter
Size:
20,526 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146 (See protein sequence)
Recommended Name: Nociceptin receptor  
Size: 370 amino acids; 40693 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for OPRL1:
4EA3 (3D)    
Secondary accessions: Q8TD34 Q8WYH9 Q9H4K4
Alternative splicing: 2 isoforms:  P41146-1   P41146-2   

Explore the universe of human proteins at neXtProt for OPRL1: NX_P41146

Explore proteomics data for OPRL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41146

  • OPRL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OPRL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000904.1  NP_001186948.1  NP_872588.1  

    ENSEMBL proteins: 
     ENSP00000336843   ENSP00000347848   ENSP00000336764  
    Reactome Protein details: P41146
    Human Recombinant Protein Products for OPRL1: 
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    Novus Biologicals OPRL1 Proteins
    Novus Biologicals OPRL1 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8137918
    GO:0016021integral to membrane ----

    OPRL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OPR: GPCR / Class A : Opioid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NOP receptor 
    Opioid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001418 Opioid_rcpt
     IPR001420 X_opioid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41146

    ProtoNet protein and cluster: P41146

    2 Blocks protein domains:
    IPB001418 Opioid receptor signature
    IPB001420 X opioid receptor signature


    UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OPRL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRX_HUMAN, P41146
    Function: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of
    brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G
    proteins which inhibits adenylyl cyclase
    Induction: By phytohemagglutinin (PHA)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001626nociceptin receptor activity IEA--
    GO:0004930G-protein coupled receptor activity IGI10571060
    GO:0005515protein binding IPI--
         
    OPRL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OPRL1:
     Decreased viability with cispl 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oprl1):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  integument  nervous system 
     normal 

    OPRL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Oprl1tm1Dgen for OPRL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OPRL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OPRL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPRL1 
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    SwitchGear 3'UTR luciferase reporter plasmidOPRL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OPRL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for OPRL1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for OPRL1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    5/7        Reactome Pathways for OPRL1 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for OPRL1):
        Neuroactive ligand-receptor interaction


    OPRL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/145 Interacting proteins for OPRL1 (P411463 ENSP000003367644) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNOCQ135193, ENSP000003019084I2D: score=3 STRING: ENSP00000301908
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GNA14O958373, ENSP000003658074I2D: score=1 STRING: ENSP00000365807
    RGS19P497953, ENSP000003331944I2D: score=2 STRING: ENSP00000333194
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS10965058
    GO:0007204elevation of cytosolic calcium ion concentration IGI10571060
    GO:0007600sensory perception TAS7566152

    OPRL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OPRL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for OPRL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+-)-J 113397Potent and selective NOP antagonist[217461-40-0]
    JTC 801Selective NOP antagonist[244218-51-7]
    BAN ORL 24Potent and selective NOP antagonist[475150-69-7]
    UFP-101 Potent, selective silent antagonist for NOP [849024-68-6]
    NociceptinEndogenous NOP agonist[170713-75-4]

    1 DrugBank Compound for OPRL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist10688973

    10/20 IUPHAR Ligands for OPRL1 (NOP receptor) (see all 20)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [(pF)Phe4]N/OFQ-(1-13)-NH2
    AgonistFull agonist10.812070757
    UFP-102
    AgonistFull agonist10.715509719
    N/OFQ-NH2
    AgonistFull agonist10.412967935
    N/OFQ-(1-13)-NH2
    AgonistFull agonist10.1 - 10.412967935 12070757 10369464 9191955
    nociceptin/orphanin FQ
    AgonistFull agonist9.7 - 10.212967935 12070757 8849681 10369464
    UFP-101
    AntagonistAntagonist10.212010780
    [3H]N/OFQ
    AgonistFull agonist10.28849681 8684262
    Ac-RYYRWK-NH2
    AgonistPartial agonist1012967935
    UFP-112
    AgonistFull agonist8.39 - 9.7117532097 19183962
    Ro64-6198
    AgonistFull agonist9.610758169

    10/18 Novoseek inferred chemical compound relationships for OPRL1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nalbzoh 83.7 5 11165763 (2), 10810242 (2)
    etorphine 73.6 2 10688973 (1), 8137918 (1)
    damgo 63.8 6 12750434 (4), 9721727 (1)
    opiate 56.4 21 20032820 (3), 17461893 (2), 11779034 (2), 9547370 (1) (see all 10)
    bremazocine 54.3 8 9749931 (4), 9547370 (1)
    morphine 44.5 5 17019122 (1), 12270145 (1), 20032820 (1)
    buprenorphine 44.1 1 10998549 (1)
    gtp 25.9 1 9547370 (1)
    naltrexone 25.6 1 9547370 (1)
    tetrapeptide 20.5 1 9930666 (1)

    Search CenterWatch for drugs/clinical trials and news about OPRL1 / OPRX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OPRL1 gene (3 alternative transcripts): 
    NM_000913.4  NM_001200019.1  NM_182647.2  

    Unigene Clusters for OPRL1:

    Opiate receptor-like 1
    Hs.2859  [show with all ESTs], Hs.736944  [show with all ESTs]
    Unigene Representative Sequences: BC038433, BQ212191
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336866(uc002yic.3 uc002yid.3) ENST00000355631(uc002yif.4)
    ENST00000349451(uc021wgs.1)

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPRL1

    Additional mRNA sequence: 

    AF285094.1 AF285095.1 

    4 DOTS entries:

    DT.207492  DT.75139287  DT.101979979  DT.100018930 

    24/38 AceView cDNA sequences (see all 38):

    AF285093 BI754749 L40949 CR542082 AY268428 AF115266 NM_182647 AF126470 
    CR604892 NM_000913 CR542061 AF348323 AW373832 BI596764 AI049744 BI825163 
    AF285094 AF285095 X77130 U30185 BM543468 AL551175 AW451157 BC038433 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for OPRL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c
    SP1:                                                        -                           
    SP2:              -     -     -                             -                           
    SP3:                                                  -     -                           
    SP4:                                                                                    
    SP5:              -     -                                                               


    ECgene alternative splicing isoforms for OPRL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPRL1 expression in normal human tissues (normalized intensities)      OPRL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAGCGT
    OPRL1 Expression
    About this image


    OPRL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 9 entries
             Metencephalon
             spinal cord/lateral wall/marginal layer   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal cord/lateral wall/marginal layer   

    See OPRL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPRL1

    SOURCE GeneReport for Unigene clusters: Hs.2859 Hs.736944
        SABiosciences Expression via Pathway-Focused PCR Array including OPRL1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OPRL1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oprl11 , 5 opioid receptor-like 11, 5 86.1(n)1
    94.55(a)1
      2 (103.74 cM)5
    183891  NM_001252565.11  NP_001239494.11 
     1817150165 
    chicken
    (Gallus gallus)
    Aves OPRL11 opiate receptor-like 1 70.29(n)
    67.12(a)
      419251  XM_417424.2  XP_417424.2 
    lizard
    (Anolis carolinensis)
    Reptilia OPRL16
    opiate receptor-like 1
    66(a)
    1 ↔ 1
    4(154996630-155030763)
    zebrafish
    (Danio rerio)
    Actinopterygii oprl11 opiate receptor-like 1 65.11(n)
    62.39(a)
      402851  NM_205589.1  NP_991152.1 


    ENSEMBL Gene Tree for OPRL1 (if available)
    TreeFam Gene Tree for OPRL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPRL1 gene
    SSTR32  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    18/34 SIMAP similar genes for OPRL1 using alignment to 2 protein entries:     OPRX_HUMAN (see all proteins) (see all similar genes):
    OPRD1    OPRK1    OPRM1    OPRMI    SSTR4    SSTR1
    NPBWR1    NPBWR2    SSTR2    GALR2    GIR    NMBR
    SSTR5    SSTR3    CMKLR1    APLNR    CCR-5    GPR24

    OPRL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in OPRL1 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452870591,2
    Cuntested162729633(+) GAGATC/TGAGTG 6 I syn10--------
    rs1466118211,2
    --62713349(+) GATAAA/GGAAAT 2 -- int10--------
    rs1165322651,2
    F--62713418(+) AGGCAC/TTCAGT 2 -- int11Minor allele frequency- T:0.08WA 118
    rs60900421,2
    C,F,A,H--62713640(+) TCCTGT/CCATCT 2 -- int120Minor allele frequency- C:0.22NS NA WA CSA EA 2014
    rs1849535461,2
    --62713715(+) AAGGGC/TAGCAA 2 -- int10--------
    rs60112861,2
    C,F,A,H--62713740(+) TAAAGC/TGCTCG 2 -- int126Minor allele frequency- T:0.21NS EA NA WA CSA 2448
    rs788399151,2
    F--62713796(+) CACCCC/GCTGGC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs783889201,2
    C,F--62713852(+) TGGACC/ACCAGT 2 -- int12Minor allele frequency- A:0.03WA NA 238
    rs45195911,2
    C,F,A--62713928(+) TCCTGC/TGGTCC 2 -- int17Minor allele frequency- T:0.13NA WA CSA 247
    rs121060281,2
    C,F--62713937(+) CCCGCT/CTCTGT 2 -- int15Minor allele frequency- C:0.13WA NA 244

    HapMap Linkage Disequilibrium report for OPRL1 (62711471 - 62731996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for OPRL1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1344965CNV Insertion17803354
    nsv509785CNV Insertion20534489
    esv2580034CNV Insertion19546169
    esv1182210CNV Insertion17803354
    dgv4663n71CNV Loss21882294
    dgv4661n71CNV Loss21882294
    dgv4659n71CNV Loss21882294
    nsv913313CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4658n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): OPRL1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for OPRL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602548    OMIM disorders: --

    14 diseases for OPRL1:    About MalaCards
    drug dependence    neurogenic bladder    agnosia    substance abuse
    temporal lobe epilepsy    panic disorder    autism spectrum disorder    vitiligo
    pertussis    alcohol dependence    alcoholism    neuroblastoma
    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OPRL1:
    Pain agnosia

    OPRL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for OPRL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 50.3 2 19273128 (1)
    drug dependence 40.6 3 17910740 (2)
    glioma 12.3 2 10501195 (1), 9038367 (1)
    alcoholism 9.76 8 18269382 (4), 17910740 (1), 20201819 (1)

    Genetic Association Database (GAD): OPRL1
    Human Genome Epidemiology (HuGE) Navigator: OPRL1 (9 documents)

    Export disorders for OPRL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPRL1 gene, integrated from 9 sources (see all 195):
    (articles sorted by number of sources associating them with OPRL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. (PubMed id 8137918)1, 2, 3, 9 Mollereau C.... Meunier C. (1994)
    2. Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (PubMed id 17910740)1, 4, 9 Xuei X....Edenberg H.J. (2008)
    3. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. (PubMed id 18269382)1, 4, 9 Huang J....Wahlestedt C. (2008)
    4. Evidence for association of two variants of the nocic eptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addi ction in Caucasians. (PubMed id 20032820)1, 4, 9 Briant J.A....Kreek M.J. (2010)
    5. Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-Epi-lipoxin A4. (PubMed id 11238602)1, 2, 9 Serhan C.N.... Pouliot M. (2001)
    6. No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort. (PubMed id 15276231)1, 4, 9 Pritchard A.... Lendon C. (2004)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    8. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4987 HGNC: 8155 AceView: OPRL1 Ensembl:ENSG00000125510 euGenes: HUgn4987
    ECgene: OPRL1 Kegg: 4987 H-InvDB: OPRL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPRL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OPRL1 gene:
    Search GeneIP for patents involving OPRL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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