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Aliases for OPRL1 Gene

Aliases for OPRL1 Gene

  • Opioid Related Nociceptin Receptor 1 2 3
  • Opiate Receptor-Like 1 2 3 5
  • Orphanin FQ Receptor 2 3 4
  • Nociceptin/Orphanin FQ Receptor 2 3
  • Kappa3-Related Opioid Receptor 2 3
  • Kappa-Type 3 Opioid Receptor 3 4
  • KOR-3 3 4
  • ORL1 3 4
  • OOR 3 4
  • LC132 Receptor-Like 2
  • NOCIR 3
  • NOPr 3
  • NOP 3

External Ids for OPRL1 Gene

Previous GeneCards Identifiers for OPRL1 Gene

  • GC20P062600
  • GC20P063390
  • GC20P063437
  • GC20P062181
  • GC20P062711
  • GC20P059457

Summaries for OPRL1 Gene

Entrez Gene Summary for OPRL1 Gene

  • The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]

GeneCards Summary for OPRL1 Gene

OPRL1 (Opioid Related Nociceptin Receptor 1) is a Protein Coding gene. Diseases associated with OPRL1 include drug dependence and pain agnosia. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and nociceptin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRL1 Gene

  • G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Tocris Summary for OPRL1 Gene

  • The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

Gene Wiki entry for OPRL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRL1 Gene

Genomics for OPRL1 Gene

Regulatory Elements for OPRL1 Gene

Transcription factor binding sites by QIAGEN in the OPRL1 gene promoter:

Genomic Location for OPRL1 Gene

Chromosome:
20
Start:
64,080,118 bp from pter
End:
64,100,643 bp from pter
Size:
20,526 bases
Orientation:
Plus strand

Genomic View for OPRL1 Gene

Genes around OPRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRL1 Gene

Proteins for OPRL1 Gene

  • Protein details for OPRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41146-OPRX_HUMAN
    Recommended name:
    Nociceptin receptor
    Protein Accession:
    P41146
    Secondary Accessions:
    • Q8TD34
    • Q8WYH9
    • Q9H4K4

    Protein attributes for OPRL1 Gene

    Size:
    370 amino acids
    Molecular mass:
    40693 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OPRL1 Gene

    Alternative splice isoforms for OPRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRL1 Gene

Proteomics data for OPRL1 Gene at MOPED

Post-translational modifications for OPRL1 Gene

  • Phosphorylation at Ser-363 requires ADRBK2.
  • Glycosylation at Asn 21, Asn 28, and Asn 39
  • Modification sites at PhosphoSitePlus

Other Protein References for OPRL1 Gene

No data available for DME Specific Peptides for OPRL1 Gene

Domains & Families for OPRL1 Gene

Gene Families for OPRL1 Gene

Suggested Antigen Peptide Sequences for OPRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41146

UniProtKB/Swiss-Prot:

OPRX_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRL1: view

Function for OPRL1 Gene

Molecular function for OPRL1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).

Gene Ontology (GO) - Molecular Function for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008022 protein C-terminus binding IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with OPRL1: view
genes like me logo Genes that share phenotypes with OPRL1: view

Animal Models for OPRL1 Gene

MGI Knock Outs for OPRL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRL1 Gene

Localization for OPRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRL1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRL1 Gene COMPARTMENTS Subcellular localization image for OPRL1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IGI --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OPRL1: view

Pathways & Interactions for OPRL1 Gene

genes like me logo Genes that share pathways with OPRL1: view

Pathways by source for OPRL1 Gene

Gene Ontology (GO) - Biological Process for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission IBA --
GO:0007600 sensory perception TAS 7566152
GO:0019233 sensory perception of pain IEA,ISS --
genes like me logo Genes that share ontologies with OPRL1: view

No data available for SIGNOR curated interactions for OPRL1 Gene

Drugs & Compounds for OPRL1 Gene

(32) Drugs for OPRL1 Gene - From: Novoseek, DrugBank, IUPHAR, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epicept NP-1 Investigational Pharma Target 0
JTC-801 Pharma Antagonist KOR-3 (NOP) receptor antagonist 0
[(pF)Phe<sup>4</sup>]N/OFQ-(1-13)-NH<sub>2</sub> Pharma Full agonist, Agonist 0
[<sup>3</sup>H]Leu-N/OFQ Pharma 0
[<sup>3</sup>H]N/OFQ Pharma Full agonist, Agonist 0

(12) Additional Compounds for OPRL1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]Tyr<sup>14</sup>-N/OFQ
[(pF)Phe4]Nociceptin(1-13)NH2
380620-88-2
[Phe1psi(CH2-NH)Gly2]Nociceptin(1-13)NH2
213130-17-7
Ac-RYYRWK-NH2
200959-47-3
Nociceptin (1-13)NH2
178064-02-3
genes like me logo Genes that share compounds with OPRL1: view

Drug Products

Transcripts for OPRL1 Gene

Unigene Clusters for OPRL1 Gene

Opiate receptor-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPRL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for OPRL1 Gene

GeneLoc Exon Structure for
OPRL1
ECgene alternative splicing isoforms for
OPRL1

Expression for OPRL1 Gene

mRNA expression in normal human tissues for OPRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRL1 Gene

This gene is overexpressed in Whole Blood (x9.2), Brain - Cortex (x5.1), and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for OPRL1 Gene

This gene is overexpressed in Adipocyte (55.0) and Plasma (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPRL1 Gene



SOURCE GeneReport for Unigene cluster for OPRL1 Gene Hs.2859

mRNA Expression by UniProt/SwissProt for OPRL1 Gene

P41146-OPRX_HUMAN
Tissue specificity: Detected in blood leukocytes.
genes like me logo Genes that share expression patterns with OPRL1: view

Protein tissue co-expression partners for OPRL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for OPRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OPRL1 35
  • 89.82 (n)
  • 94.59 (a)
OPRL1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRL1 35
  • 90.45 (n)
  • 96.49 (a)
OPRL1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprl1 35
  • 85.2 (n)
  • 93.19 (a)
Oprl1 16
Oprl1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprl1 35
  • 84.56 (n)
  • 92.64 (a)
oppossum
(Monodelphis domestica)
Mammalia OPRL1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRL1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRL1 35
  • 70.29 (n)
  • 67.12 (a)
OPRL1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRL1 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oprl1 35
  • 66.87 (n)
  • 64.53 (a)
oprl1 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AR-2 37
  • 36 (a)
Drostar1 37
  • 37 (a)
Species with no ortholog for OPRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRL1 Gene

ENSEMBL:
Gene Tree for OPRL1 (if available)
TreeFam:
Gene Tree for OPRL1 (if available)

Paralogs for OPRL1 Gene

genes like me logo Genes that share paralogs with OPRL1: view

Variants for OPRL1 Gene

Sequence variations from dbSNP and Humsavar for OPRL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1059601 -- 64,100,526(+) TCACG(C/T)ATTTA utr-variant-3-prime
rs2229204 -- 64,092,882(+) ACCAT(C/T)GTGGG intron-variant, reference, synonymous-codon
rs2229205 -- 64,098,078(+) GCTGT(C/T)AATGT reference, synonymous-codon
rs2229206 -- 64,098,812(+) TGGAC(A/C/G)TGCCC utr-variant-3-prime
rs3215634 -- 64,100,110(-) CCCCC(-/C)AACCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OPRL1 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
dgv4659n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4661n71 CNV Loss 21882294
dgv4662n71 CNV Loss 21882294
nsv913313 CNV Loss 21882294
nsv913314 CNV Loss 21882294
dgv4663n71 CNV Loss 21882294
dgv710n67 CNV Gain 20364138
esv1344965 CNV Insertion 17803354
esv1182210 CNV Insertion 17803354
esv26753 CNV Gain 19812545
esv2580034 CNV Insertion 19546169

Variation tolerance for OPRL1 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRL1 Gene

HapMap Linkage Disequilibrium report
OPRL1
Human Gene Mutation Database (HGMD)
OPRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRL1 Gene

Disorders for OPRL1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for OPRL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
drug dependence
  • substance dependence
pain agnosia
  • analgesia
agnosia
  • alexia
rectal prolapse
  • procidentia, rectum
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search OPRL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRL1

Genetic Association Database (GAD)
OPRL1
Human Genome Epidemiology (HuGE) Navigator
OPRL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRL1
genes like me logo Genes that share disorders with OPRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRL1 Gene

Publications for OPRL1 Gene

  1. Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (PMID: 17910740) Xuei X. … Edenberg H.J. (Addict Biol 2008) 2 3 23 48 67
  2. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. (PMID: 8137918) Mollereau C. … Meunier C. (FEBS Lett. 1994) 2 3 23
  3. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. (PMID: 20032820) Briant J.A. … Kreek M.J. (Psychiatr. Genet. 2010) 3 23
  4. Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics. (PMID: 19501074) Kuzmin A. … Bakalkin G. (Brain Res. 2009) 3 23
  5. Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes. (PMID: 18247127) Kaminsky D.E. … Rogers T.J. (J Neuroimmune Pharmacol 2008) 3 23

Products for OPRL1 Gene

Sources for OPRL1 Gene

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