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Aliases for OPRL1 Gene

Aliases for OPRL1 Gene

  • Opiate Receptor-Like 1 2 3
  • Orphanin FQ Receptor 2 3 4
  • Kappa3-Related Opioid Receptor 2 3
  • Kappa-Type 3 Opioid Receptor 3 4
  • KOR-3 3 4
  • ORL1 3 4
  • OOR 3 4
  • LC132 Receptor-Like 2
  • Nociceptin Receptor 3
  • NOCIR 3

External Ids for OPRL1 Gene

Previous GeneCards Identifiers for OPRL1 Gene

  • GC20P062600
  • GC20P063390
  • GC20P063437
  • GC20P062181
  • GC20P062711
  • GC20P059457

Summaries for OPRL1 Gene

Entrez Gene Summary for OPRL1 Gene

  • The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for OPRL1 Gene

OPRL1 (Opiate Receptor-Like 1) is a Protein Coding gene. Diseases associated with OPRL1 include drug dependence and pain agnosia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and nociceptin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRL1 Gene

  • G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Tocris Summary for OPRL1 Gene

  • The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord. The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

Gene Wiki entry for OPRL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRL1 Gene

Genomics for OPRL1 Gene

Regulatory Elements for OPRL1 Gene

Transcription factor binding sites by QIAGEN in the OPRL1 gene promoter:

Genomic Location for OPRL1 Gene

Start:
64,080,098 bp from pter
End:
64,100,643 bp from pter
Size:
20,546 bases
Orientation:
Plus strand

Genomic View for OPRL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRL1 Gene

Proteins for OPRL1 Gene

  • Protein details for OPRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41146-OPRX_HUMAN
    Recommended name:
    Nociceptin receptor
    Protein Accession:
    P41146
    Secondary Accessions:
    • Q8TD34
    • Q8WYH9
    • Q9H4K4

    Protein attributes for OPRL1 Gene

    Size:
    370 amino acids
    Molecular mass:
    40693 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OPRL1 Gene

    Alternative splice isoforms for OPRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRL1 Gene

Proteomics data for OPRL1 Gene at MOPED

Post-translational modifications for OPRL1 Gene

Other Protein References for OPRL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OPRL1 Gene

Domains for OPRL1 Gene

Gene Families for OPRL1 Gene

HGNC:
  • OPR :GPCR / Class A : Opioid receptors
IUPHAR :

Suggested Antigen Peptide Sequences for OPRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41146

UniProtKB/Swiss-Prot:

OPRX_HUMAN :
  • P41146
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRL1: view

Function for OPRL1 Gene

Molecular function for OPRL1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).

Gene Ontology (GO) - Molecular Function for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001626 nociceptin receptor activity IDA 12568343
GO:0004930 G-protein coupled receptor activity IMP 8137918
GO:0005515 protein binding IPI 23597562
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with OPRL1: view
genes like me logo Genes that share phenotypes with OPRL1: view

Animal Models for OPRL1 Gene

MGI Knock Outs for OPRL1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPRL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OPRL1 Gene

Localization for OPRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRL1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRL1 Gene COMPARTMENTS Subcellular localization image for OPRL1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12568343
GO:0016021 integral component of membrane --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with OPRL1: view

Pathways for OPRL1 Gene

genes like me logo Genes that share pathways with OPRL1: view

Pathways by source for OPRL1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 12568343
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 10571060
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
genes like me logo Genes that share ontologies with OPRL1: view

Compounds for OPRL1 Gene

Compound Products

(5) Tocris Compounds for OPRL1 Gene

Compound Action Cas Number
(�)-J 113397 Potent and selective NOP antagonist [217461-40-0]
BAN ORL 24 Potent and selective NOP antagonist [1401463-54-4]
JTC 801 Selective NOP antagonist [244218-51-7]
SB 612111 hydrochloride Selective NOP receptor antagonist [371980-94-8]
SCH 221510 Potent and selective NOP agonist [322473-89-2]

(1) ApexBio Compounds for OPRL1 Gene

Compound Action Cas Number
JTC-801 KOR-3 (NOP) receptor antagonist [244218-51-7]

(1) Drugbank Compounds for OPRL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Etorphine
  • 19-Propylorvinol
14521-96-1 target agonist

(20) IUPHAR Ligand for OPRL1 Gene

Ligand Type Action Affinity Pubmed IDs
[(pF)Phe4]N/OFQ-(1-13)-NH2 Agonist Full agonist 10.8
UFP-102 Agonist Full agonist 10.7
N/OFQ-NH2 Agonist Full agonist 10.4
N/OFQ-(1-13)-NH2 Agonist Full agonist 10.4
nociceptin/orphanin FQ Agonist Full agonist 10.2
UFP-101 Antagonist Antagonist 10.2
[3H]N/OFQ Agonist Full agonist 10.2
Ac-RYYRWK-NH2 Agonist Partial agonist 10
UFP-112 Agonist Full agonist 9.71
Ro64-6198 Agonist Full agonist 9.6
[Arg14Lys15]N/OFQ Agonist Full agonist 9.5
SB 612111 Antagonist Antagonist 9.5
[F/G]N/OFQ-(1-13)-NH2 Agonist Partial agonist 9.2
Ac-RYYRIK-NH2 Agonist Partial agonist 9.1
J-113397 Antagonist Antagonist 8.7
[Nphe1]N/OFQ-(1-13)-NH2 Antagonist Antagonist 8.4
JTC-801 Antagonist Antagonist 8.1
peptide III-BTD Antagonist Antagonist 7.6
[3H]Leu-N/OFQ None None
[125I]Tyr14-N/OFQ None None

(18) Novoseek inferred chemical compound relationships for OPRL1 Gene

Compound -log(P) Hits PubMed IDs
nalbzoh 83.7 4
etorphine 73.6 2
damgo 63.8 5
opiate 56.4 14
bremazocine 54.3 5
genes like me logo Genes that share compounds with OPRL1: view

Transcripts for OPRL1 Gene

Unigene Clusters for OPRL1 Gene

Opiate receptor-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPRL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for OPRL1 Gene

GeneLoc Exon Structure for
OPRL1
ECgene alternative splicing isoforms for
OPRL1

Expression for OPRL1 Gene

mRNA expression in normal human tissues for OPRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRL1 Gene

This gene is overexpressed in Whole Blood (9.2), Brain - Cortex (5.1), and Brain - Frontal Cortex (BA9) (4.0).

Protein differential expression in normal tissues for OPRL1 Gene

This gene is overexpressed in Adipocyte (55.0) and Plasma (14.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OPRL1 Gene

SOURCE GeneReport for Unigene cluster for OPRL1 Gene Hs.2859

mRNA Expression by UniProt/SwissProt for OPRL1 Gene

P41146-OPRX_HUMAN
Tissue specificity: Detected in blood leukocytes.
genes like me logo Genes that share expressions with OPRL1: view

Expression partners for OPRL1 Gene

In Situ Assay Products

Orthologs for OPRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OPRL1 35
  • 89.82 (n)
  • 94.59 (a)
OPRL1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRL1 35
  • 90.45 (n)
  • 96.49 (a)
OPRL1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprl1 35
  • 85.2 (n)
  • 93.19 (a)
Oprl1 16
Oprl1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprl1 35
  • 84.56 (n)
  • 92.64 (a)
oppossum
(Monodelphis domestica)
Mammalia OPRL1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRL1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRL1 35
  • 70.29 (n)
  • 67.12 (a)
OPRL1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRL1 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oprl1 35
  • 66.87 (n)
  • 64.53 (a)
oprl1 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta AR-2 37
  • 36 (a)
Drostar1 37
  • 37 (a)
Species with no ortholog for OPRL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRL1 Gene

ENSEMBL:
Gene Tree for OPRL1 (if available)
TreeFam:
Gene Tree for OPRL1 (if available)

Paralogs for OPRL1 Gene

genes like me logo Genes that share paralogs with OPRL1: view

Variants for OPRL1 Gene

Sequence variations from dbSNP and Humsavar for OPRL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1059601 -- 64,100,526(+) TCACG(C/T)ATTTA utr-variant-3-prime
rs2229204 -- 64,092,882(+) ACCAT(C/T)GTGGG reference, synonymous-codon, intron-variant
rs2229205 -- 64,098,078(+) GCTGT(C/T)AATGT reference, synonymous-codon
rs2229206 -- 64,098,812(+) TGGAC(C/G)TGCCC utr-variant-3-prime
rs2295448 -- 64,098,224(-) GGCAC(A/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRL1 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
dgv4659n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4661n71 CNV Loss 21882294
dgv4662n71 CNV Loss 21882294
nsv913313 CNV Loss 21882294
nsv913314 CNV Loss 21882294
dgv4663n71 CNV Loss 21882294
dgv710n67 CNV Gain 20364138
esv1344965 CNV Insertion 17803354
esv1182210 CNV Insertion 17803354
esv26753 CNV Gain 19812545
esv2580034 CNV Insertion 19546169

Relevant External Links for OPRL1 Gene

HapMap Linkage Disequilibrium report
OPRL1
Human Gene Mutation Database (HGMD)
OPRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRL1 Gene

Disorders for OPRL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OPRL1 Gene in MalaCards »

(3) Diseases for OPRL1 Gene including...

(1) University of Copenhagen DISEASES for OPRL1 Gene

(4) Novoseek inferred disease relationships for OPRL1 Gene

Disease -log(P) Hits PubMed IDs
hyperalgesia 50.3 1
drug dependence 40.6 2
glioma 12.3 2
alcoholism 9.76 6

Relevant External Links for OPRL1

Genetic Association Database (GAD)
OPRL1
Human Genome Epidemiology (HuGE) Navigator
OPRL1
genes like me logo Genes that share disorders with OPRL1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for OPRL1 Gene

Publications for OPRL1 Gene

  1. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. (PMID: 8137918) Mollereau C. … Meunier C. (FEBS Lett. 1994) 2 3 4 23
  2. Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-Epi-lipoxin A4. (PMID: 11238602) Serhan C.N. … Pouliot M. (J. Immunol. 2001) 3 4 23
  3. Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells. (PMID: 12568343) Spampinato S. … Murari G. (Cell. Mol. Life Sci. 2002) 3 4 23
  4. No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort. (PMID: 15276231) Pritchard A. … Lendon C. (Neurosci. Lett. 2004) 3 23 48
  5. Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (PMID: 17910740) Xuei X. … Edenberg H.J. (Addict Biol 2008) 3 23 48

Products for OPRL1 Gene

Sources for OPRL1 Gene

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