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OPRL1 Gene

protein-coding   GIFtS: 64
GCID: GC20P062711

Opiate Receptor-Like 1

  See OPRL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opiate Receptor-Like 11 2     OOR2 3
Orphanin FQ Receptor1 2 3     ORL12 3
Kappa3-Related Opioid Receptor1 2     LC132 Receptor-Like1
Kappa-Type 3 Opioid Receptor2 3     NOCIR2
KOR-32 3     Nociceptin Receptor2

External Ids:    HGNC: 81551   Entrez Gene: 49872   Ensembl: ENSG000001255107   OMIM: 6025485   UniProtKB: P411463   

Export aliases for OPRL1 gene to outside databases

Previous GC identifers: GC20P062600 GC20P063390 GC20P063437 GC20P062181 GC20P059457


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPRL1 Gene:
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by
phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide
nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly
instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene,
regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for OPRL1 Gene:
OPRL1 (opiate receptor-like 1) is a protein-coding gene. Diseases associated with OPRL1 include drug dependence, and pain agnosia. GO annotations related to this gene include nociceptin receptor activity and G-protein coupled receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146
Function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G
proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of
adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate
the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in
modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the
neuropeptide nociceptin

summary for OPRL1 Gene:
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of
G-protein-coupled receptors that also includes kappa, delta and mu receptors. NOP receptor mRNA is found in
high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala,
central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and
spinal cord. The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor
and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression
and autonomic control of physiological processes. The human gene encoding the NOP receptor has been
localized to chromosome 20 (20q13.33).

Gene Wiki entry for OPRL1 (Nociceptin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  NT_187624.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPRL1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRL1 promoter sequence
   Search Chromatin IP Primers for OPRL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

OPRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062711:  view genomic region     (about GC identifiers)

Start:
62,711,471 bp from pter      End:
62,731,996 bp from pter
Size:
20,526 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146 (See protein sequence)
Recommended Name: Nociceptin receptor  
Size: 370 amino acids; 40693 Da
1 PDB 3D structure from and Proteopedia for OPRL1:
4EA3 (3D)    
Secondary accessions: Q8TD34 Q8WYH9 Q9H4K4
Alternative splicing: 2 isoforms:  P41146-1   P41146-2   

Explore the universe of human proteins at neXtProt for OPRL1: NX_P41146

Explore proteomics data for OPRL1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-363 requires ADRBK21
  • Glycosylation2 at Asn21, Asn28, Asn39
  • Modification sites at PhosphoSitePlus

  • See OPRL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000904.1  NP_001186948.1  NP_872588.1  

    ENSEMBL proteins: 
     ENSP00000336843   ENSP00000347848   ENSP00000336764  
    Reactome Protein details: P41146

    OPRL1 Human Recombinant Protein Products:

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    Novus Biologicals OPRL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for OPRL1 

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    Search eBioscience for ELISAs for OPRL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPR: GPCR / Class A : Opioid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NOP receptor
    Opioid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001418 Opioid_rcpt
     IPR001420 X_opioid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41146

    ProtoNet protein and cluster: P41146

    2 Blocks protein domains:
    IPB001418 Opioid receptor signature
    IPB001420 X opioid receptor signature


    UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OPRL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRX_HUMAN, P41146
    Function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin.
    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G
    proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of
    adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate
    the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in
    modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the
    neuropeptide nociceptin
    Induction: By phytohemagglutinin (PHA)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001626nociceptin receptor activity IDA12568343
    GO:0004930G-protein coupled receptor activity IMP8137918
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with OPRL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OPRL1:
     Decreased viability with cispl 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oprl1):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  integument  nervous system 
     normal 

    Find genes that share phenotypes with OPRL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Oprl1tm1Dgen for OPRL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPRL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPRL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPRL1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate OPRL1 (see all 9):
    hsa-miR-631 hsa-miR-3660 hsa-miR-2278 hsa-miR-767-5p hsa-miR-3661 hsa-miR-513b hsa-miR-593* hsa-miR-3147
    SwitchGear 3'UTR luciferase reporter plasmidOPRL1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): OPRL1 (NM_000913)
    Sino Biological Human cDNA Clone for OPRL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPRX_HUMAN, P41146: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads
    to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell
    surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA12568343
    GO:0016021integral component of membrane ----
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with OPRL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPRL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OPRL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OPRL1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for OPRL1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for OPRL1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including OPRL1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OPRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OPRL1 (P411463 ENSP000003367644) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNOCQ135193, ENSP000003019084I2D: score=3 STRING: ENSP00000301908
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GNA14O958373, ENSP000003658074I2D: score=1 STRING: ENSP00000365807
    RGS19P497953, ENSP000003331944I2D: score=2 STRING: ENSP00000333194
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP12568343
    GO:0007204positive regulation of cytosolic calcium ion concentration IGI10571060
    GO:0007600sensory perception TAS7566152
    GO:0007610behavior IEA--

    Find genes that share ontologies with OPRL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for OPRL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+-)-J 113397Potent and selective NOP antagonist[217461-40-0]
    JTC 801Selective NOP antagonist[244218-51-7]
    BAN ORL 24Potent and selective NOP antagonist[475150-69-7]
    UFP-101 Potent, selective silent antagonist for NOP [849024-68-6]
    NociceptinEndogenous NOP agonist[170713-75-4]

    1 DrugBank Compound for OPRL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist10688973

    Selected IUPHAR Ligands for OPRL1 (NOP receptor) (see all 20)    About this table
    LigandTypeActionAffinityPubmed IDs
    [(pF)Phe4]N/OFQ-(1-13)-NH2
    AgonistFull agonist10.812070757
    UFP-102
    AgonistFull agonist10.715509719
    N/OFQ-NH2
    AgonistFull agonist10.412967935
    N/OFQ-(1-13)-NH2
    AgonistFull agonist10.1 - 10.412967935 12070757 10369464 9191955
    nociceptin/orphanin FQ
    AgonistFull agonist9.7 - 10.212967935 12070757 8849681 10369464
    UFP-101
    AntagonistAntagonist10.212010780
    [3H]N/OFQ
    AgonistFull agonist10.28849681 8684262
    Ac-RYYRWK-NH2
    AgonistPartial agonist1012967935
    UFP-112
    AgonistFull agonist8.39 - 9.7117532097 19183962
    Ro64-6198
    AgonistFull agonist9.610758169

    Selected Novoseek inferred chemical compound relationships for OPRL1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nalbzoh 83.7 5 11165763 (2), 10810242 (2)
    etorphine 73.6 2 10688973 (1), 8137918 (1)
    damgo 63.8 6 12750434 (4), 9721727 (1)
    opiate 56.4 21 20032820 (3), 17461893 (2), 11779034 (2), 9547370 (1) (see all 10)
    bremazocine 54.3 8 9749931 (4), 9547370 (1)
    morphine 44.5 5 17019122 (1), 12270145 (1), 20032820 (1)
    buprenorphine 44.1 1 10998549 (1)
    gtp 25.9 1 9547370 (1)
    naltrexone 25.6 1 9547370 (1)
    tetrapeptide 20.5 1 9930666 (1)



    Find genes that share compounds with OPRL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OPRL1 gene (3 alternative transcripts): 
    NM_000913.4  NM_001200019.1  NM_182647.2  

    Unigene Cluster for OPRL1:

    Opiate receptor-like 1
    Hs.2859  [show with all ESTs]
    Unigene Representative Sequence: BC038433
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336866(uc002yic.3 uc002yid.3) ENST00000355631(uc002yif.4)
    ENST00000349451(uc021wgs.1)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat OPRL1
      QuantiFast Probe-based Assays in human, mouse, rat OPRL1

    Additional mRNA sequence: 

    AF115266.1 AF126470.1 AF285093.1 AF348323.1 AK308203.1 AY268428.1 BC038433.1 CR542061.1 
    CR542082.1 L40949.1 U30185.1 X77130.1 

    4 DOTS entries:

    DT.207492  DT.75139287  DT.101979979  DT.100018930 

    Selected AceView cDNA sequences (see all 38):

    CR542061 AF115266 NM_182647 CR604892 L40949 CR542082 AF126470 NM_000913 
    AY268428 AF285093 AF348323 BI754749 CD246184 AL551175 BM546464 AA889849 
    AW373832 U30185 AW451157 AL574931 BI596764 BI825163 BC038433 AI049744 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for OPRL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c
    SP1:                                                        -                           
    SP2:              -     -     -                             -                           
    SP3:                                                  -     -                           
    SP4:                                                                                    
    SP5:              -     -                                                               


    ECgene alternative splicing isoforms for OPRL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OPRL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAGCGT
    OPRL1 Expression
    About this image


    OPRL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Medulla Oblongata
    OPRL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPRL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2859

    UniProtKB/Swiss-Prot: OPRX_HUMAN, P41146
    Tissue specificity: Detected in blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including OPRL1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPRL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oprl11 , 5 opioid receptor-like 11, 5 85.2(n)1
    93.19(a)1
      2 (103.74 cM)5
    183891  NM_011012.51  NP_035142.11 
     1817150165 
    chicken
    (Gallus gallus)
    Aves OPRL11 opiate receptor-like 1 70.29(n)
    67.12(a)
      419251  XM_417424.3  XP_417424.2 
    lizard
    (Anolis carolinensis)
    Reptilia OPRL16
    opiate receptor-like 1
    66(a)
    1 ↔ 1
    4(154996630-155030763)
    zebrafish
    (Danio rerio)
    Actinopterygii oprl11 opiate receptor-like 1 66.87(n)
    64.53(a)
      402851  NM_205589.1  NP_991152.1 


    ENSEMBL Gene Tree for OPRL1 (if available)
    TreeFam Gene Tree for OPRL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPRL1 gene
    SSTR32  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for OPRL1 using alignment to 2 protein entries:     OPRX_HUMAN (see all proteins) (see all similar genes):
    OPRD1    OPRK1    OPRM1    OPRMI    SSTR4    SSTR1
    NPBWR1    NPBWR2    SSTR2    GALR2    GIR    NMBR
    SSTR5    SSTR3    CMKLR1    APLNR    CCR-5    GPR24

    Find genes that share paralogs with OPRL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPRL1 (see all 464)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452870591,2
    Cuntested162729633(+) GAGATC/TGAGTG 6 I syn10--------
    rs1466118211,2
    --62713349(+) GATAAA/GGAAAT 2 -- int10--------
    rs1165322651,2
    F--62713418(+) AGGCAC/TTCAGT 2 -- int11Minor allele frequency- T:0.08WA 118
    rs60900421,2
    C,F,A,H--62713640(+) TCCTGT/CCATCT 2 -- int120Minor allele frequency- C:0.22NS NA WA CSA EA 2014
    rs1849535461,2
    --62713715(+) AAGGGC/TAGCAA 2 -- int10--------
    rs60112861,2
    C,F,A,H--62713740(+) TAAAGC/TGCTCG 2 -- int126Minor allele frequency- T:0.21NS EA NA WA CSA 2448
    rs788399151,2
    F--62713796(+) CACCCC/GCTGGC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs783889201,2
    C,F--62713852(+) TGGACC/ACCAGT 2 -- int12Minor allele frequency- A:0.03WA NA 238
    rs45195911,2
    C,F,A--62713928(+) TCCTGC/TGGTCC 2 -- int17Minor allele frequency- T:0.13NA WA CSA 247
    rs121060281,2
    C,F--62713937(+) CCCGCT/CTCTGT 2 -- int15Minor allele frequency- C:0.13WA NA 244

    HapMap Linkage Disequilibrium report for OPRL1 (62711471 - 62731996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OPRL1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1344965CNV Insertion17803354
    nsv509785CNV Insertion20534489
    esv2580034CNV Insertion19546169
    esv1182210CNV Insertion17803354
    dgv4663n71CNV Loss21882294
    dgv4661n71CNV Loss21882294
    dgv4659n71CNV Loss21882294
    nsv913313CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4658n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): OPRL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPRL1
    DNA2.0 Custom Variant and Variant Library Synthesis for OPRL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602548    OMIM disorders: --

    3 diseases for OPRL1:    
    About MalaCards
    drug dependence    pain agnosia    agnosia

    1 disease from the University of Copenhagen DISEASES database for OPRL1:
    Pain agnosia

    Find genes that share disorders with OPRL1           About GenesLikeMe

    4 Novoseek inferred disease relationships for OPRL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 50.3 2 19273128 (1)
    drug dependence 40.6 3 17910740 (2)
    glioma 12.3 2 10501195 (1), 9038367 (1)
    alcoholism 9.76 8 18269382 (4), 17910740 (1), 20201819 (1)

    Genetic Association Database (GAD): OPRL1
    Human Genome Epidemiology (HuGE) Navigator: OPRL1 (9 documents)

    Export disorders for OPRL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPRL1 gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with OPRL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. (PubMed id 8137918)1, 2, 3, 9 Mollereau C.... Meunier C. (FEBS Lett. 1994)
    2. Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (PubMed id 17910740)1, 4, 9 Xuei X....Edenberg H.J. (Addict Biol 2008)
    3. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. (PubMed id 18269382)1, 4, 9 Huang J....Wahlestedt C. (Addict Biol 2008)
    4. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. (PubMed id 20032820)1, 4, 9 Briant J.A....Kreek M.J. (Psychiatr. Genet. 2010)
    5. Nociceptin stimulates neutrophil chemotaxis and recruitment: Inhibition by aspirin-triggered-15-Epi-lipoxin A4. (PubMed id 11238602)1, 2, 9 Serhan C.N.... Pouliot M. (J. Immunol. 2001)
    6. No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort. (PubMed id 15276231)1, 4, 9 Pritchard A.... Lendon C. (Neurosci. Lett. 2004)
    7. Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells. (PubMed id 12568343)1, 2, 9 Spampinato S....Murari G. (Cell. Mol. Life Sci. 2002)
    8. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. (PubMed id 22596163)1, 2 Thompson A.A....Stevens R.C. (Nature 2012)
    9. Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. (PubMed id 23086955)1, 2 Zhang N.R....Bruchas M.R. (J. Biol. Chem. 2012)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4987 HGNC: 8155 AceView: OPRL1 Ensembl:ENSG00000125510 euGenes: HUgn4987
    ECgene: OPRL1 Kegg: 4987 H-InvDB: OPRL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OPRL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPRL1 gene:
    Search GeneIP for patents involving OPRL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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