Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OPRL1 Gene

Aliases for OPRL1 Gene

  • Opioid Related Nociceptin Receptor 1 2 3 5
  • Orphanin FQ Receptor 2 3 4
  • Nociceptin/Orphanin FQ Receptor 2 3
  • Kappa3-Related Opioid Receptor 2 3
  • Kappa-Type 3 Opioid Receptor 3 4
  • Opiate Receptor-Like 1 2 3
  • KOR-3 3 4
  • ORL1 3 4
  • OOR 3 4
  • LC132 Receptor-Like 2
  • Nociceptin Receptor 3
  • NOCIR 3
  • NOPr 3
  • NOP 3

External Ids for OPRL1 Gene

Previous GeneCards Identifiers for OPRL1 Gene

  • GC20P062600
  • GC20P063390
  • GC20P063437
  • GC20P062181
  • GC20P062711
  • GC20P059457

Summaries for OPRL1 Gene

Entrez Gene Summary for OPRL1 Gene

  • The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]

GeneCards Summary for OPRL1 Gene

OPRL1 (Opioid Related Nociceptin Receptor 1) is a Protein Coding gene. Diseases associated with OPRL1 include Drug Dependence and Pain Agnosia. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. GO annotations related to this gene include G-protein coupled receptor activity and nociceptin receptor activity. An important paralog of this gene is OPRK1.

UniProtKB/Swiss-Prot for OPRL1 Gene

  • G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Tocris Summary for OPRL1 Gene

  • The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

Gene Wiki entry for OPRL1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRL1 Gene

Genomics for OPRL1 Gene

Regulatory Elements for OPRL1 Gene

Enhancers for OPRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G064052 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -24.5 -24483 5.7 HDGF FOXA2 PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SOX18 RGS19 TCEA2 PRPF6 OPRL1 SAMD10 ZNF512B ENSG00000237371 C20orf204 UCKL1
GH20G063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -183.4 -183427 5.4 HDGF FOXA2 PKNOX1 ARNT MLX AGO1 WRNIP1 SIN3A ARID4B DMAP1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181 FNDC11
GH20G063902 1.4 Ensembl ENCODE dbSUPER 10.4 -176.6 -176619 2.2 HDGF ATF1 PKNOX1 TCF12 GLIS2 ZNF592 MBD2 SMARCA4 MYNN GLIS1 FNDC11 SRMS ZBTB46 ZBTB46-AS1 ENSG00000229299 C20orf181 OPRL1 RGS19 LKAAEAR1 MIR941-1
GH20G064160 1.3 ENCODE dbSUPER 10.6 +80.6 80598 1.2 ARID4B SIN3A ZNF2 ZNF143 ZNF207 KLF13 DEK SP3 SP5 MXD4 LKAAEAR1 OPRL1 RGS19 GC20P064162 GC20P064163 MYT1
GH20G063900 0.8 Ensembl dbSUPER 10.4 -179.2 -179218 1.8 ZNF341 ZBTB11 CEBPB HNRNPL EZH2 RBFOX2 ZNF592 SRMS FNDC11 ZBTB46 ZBTB46-AS1 ENSG00000229299 C20orf181 RGS19 OPRL1 LKAAEAR1 MIR941-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OPRL1 on UCSC Golden Path with GeneCards custom track

Promoters for OPRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000299358 -518 2401 PKNOX1 CREB3L1 SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 KLF13 SP3

Transcription factor binding sites by QIAGEN in the OPRL1 gene promoter:

Genomic Location for OPRL1 Gene

Chromosome:
20
Start:
64,080,118 bp from pter
End:
64,100,643 bp from pter
Size:
20,526 bases
Orientation:
Plus strand

Genomic View for OPRL1 Gene

Genes around OPRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRL1 Gene

Proteins for OPRL1 Gene

  • Protein details for OPRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41146-OPRX_HUMAN
    Recommended name:
    Nociceptin receptor
    Protein Accession:
    P41146
    Secondary Accessions:
    • Q8TD34
    • Q8WYH9
    • Q9H4K4

    Protein attributes for OPRL1 Gene

    Size:
    370 amino acids
    Molecular mass:
    40693 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OPRL1 Gene

    Alternative splice isoforms for OPRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRL1 Gene

Post-translational modifications for OPRL1 Gene

  • Phosphorylation at Ser-363 requires GRK3.
  • Glycosylation at Asn21, Asn28, and posLast=3939
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPRL1 Gene

Domains & Families for OPRL1 Gene

Gene Families for OPRL1 Gene

Suggested Antigen Peptide Sequences for OPRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41146

UniProtKB/Swiss-Prot:

OPRX_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRL1: view

Function for OPRL1 Gene

Molecular function for OPRL1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).

Gene Ontology (GO) - Molecular Function for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001626 nociceptin receptor activity IDA 12568343
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IMP 8137918
GO:0004985 opioid receptor activity IEA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with OPRL1: view
genes like me logo Genes that share phenotypes with OPRL1: view

Animal Models for OPRL1 Gene

MGI Knock Outs for OPRL1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OPRL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRL1 Gene

Localization for OPRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRL1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPRL1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8137918
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with OPRL1: view

Pathways & Interactions for OPRL1 Gene

genes like me logo Genes that share pathways with OPRL1: view

Gene Ontology (GO) - Biological Process for OPRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 8137918
GO:0007204 positive regulation of cytosolic calcium ion concentration IGI 10571060
genes like me logo Genes that share ontologies with OPRL1: view

No data available for SIGNOR curated interactions for OPRL1 Gene

Drugs & Compounds for OPRL1 Gene

(51) Drugs for OPRL1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epicept NP-1 Investigational Pharma Target 0
JTC-801 Pharma Antagonist KOR-3 (NOP) receptor antagonist 0
UFP-101 Pharma Antagonist 0
BAN ORL 24 Pharma NOP receptor antagonist, potent and selective, Potent and selective NOP antagonist 0
Nociceptin Pharma Endogenous NOP agonist 6

(10) Additional Compounds for OPRL1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]Tyr<sup>14</sup>-N/OFQ
(+-)-J 113397
217461-40-0
JTC 801
244218-51-7

(5) Tocris Compounds for OPRL1 Gene

Compound Action Cas Number
(+-)-J 113397 Potent and selective NOP antagonist 217461-40-0
BAN ORL 24 Potent and selective NOP antagonist 1401463-54-4
JTC 801 Selective NOP antagonist 244218-51-7
Nociceptin Endogenous NOP agonist 170713-75-4
SCH 221510 Potent and selective NOP agonist 322473-89-2

(22) ApexBio Compounds for OPRL1 Gene

Compound Action Cas Number
(±)-J 113397 NOP antagonist,potent and selective 217461-40-0
[(pF)Phe4]Nociceptin(1-13)NH2 380620-88-2
[Arg14,Lys15]Nociceptin 236098-40-1
[Nphe1]Nociceptin(1-13)NH2 267234-08-2
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 213130-17-7
Ac-RYYRIK-NH2 200959-48-4
Ac-RYYRWK-NH2 200959-47-3
BAN ORL 24 NOP receptor antagonist, potent and selective 475150-69-7
Cebranopadol ORL-1 agonist 863513-91-1
JTC-801 KOR-3 (NOP) receptor antagonist 244218-51-7
MCOPPB trihydrochloride NOP receptor agonist 1108147-88-1
NNC 63-0532 250685-44-0
Nociceptin 170713-75-4
Nociceptin (1-13)NH2 178064-02-3
Nociceptin (1-7) 178249-42-8
NocII 188119-47-3
Nocistatin (human) 212609-11-5
Orphanin FQ (1-11) 178249-41-7
SB 612111 hydrochloride 371980-94-8
SCH 221510 322473-89-2
Trap 101 1216621-00-9
UFP-101 849024-68-6
genes like me logo Genes that share compounds with OPRL1: view

Drug Products

Transcripts for OPRL1 Gene

Unigene Clusters for OPRL1 Gene

Opiate receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OPRL1

Alternative Splicing Database (ASD) splice patterns (SP) for OPRL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for OPRL1 Gene

GeneLoc Exon Structure for
OPRL1
ECgene alternative splicing isoforms for
OPRL1

Expression for OPRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OPRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRL1 Gene

This gene is overexpressed in Whole Blood (x9.2), Brain - Cortex (x5.1), and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for OPRL1 Gene

This gene is overexpressed in Adipocyte (55.0) and Plasma (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPRL1 Gene



Protein tissue co-expression partners for OPRL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OPRL1 Gene:

OPRL1

SOURCE GeneReport for Unigene cluster for OPRL1 Gene:

Hs.2859

mRNA Expression by UniProt/SwissProt for OPRL1 Gene:

P41146-OPRX_HUMAN
Tissue specificity: Detected in blood leukocytes.

Evidence on tissue expression from TISSUES for OPRL1 Gene

  • Nervous system(4.8)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with OPRL1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OPRL1 Gene

Orthologs for OPRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPRL1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OPRL1 34 35
  • 90.45 (n)
cow
(Bos Taurus)
Mammalia OPRL1 34 35
  • 89.82 (n)
mouse
(Mus musculus)
Mammalia Oprl1 34 16 35
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Oprl1 34
  • 84.56 (n)
oppossum
(Monodelphis domestica)
Mammalia OPRL1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRL1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRL1 34 35
  • 70.29 (n)
lizard
(Anolis carolinensis)
Reptilia OPRL1 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oprl1 34 35
  • 66.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Drostar1 36
  • 37 (a)
AR-2 36
  • 36 (a)
Species where no ortholog for OPRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRL1 Gene

ENSEMBL:
Gene Tree for OPRL1 (if available)
TreeFam:
Gene Tree for OPRL1 (if available)

Paralogs for OPRL1 Gene

genes like me logo Genes that share paralogs with OPRL1: view

Variants for OPRL1 Gene

Sequence variations from dbSNP and Humsavar for OPRL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000129702 -- 64,082,597(+) AGCCT(C/G)CTGGG intron-variant, upstream-variant-2KB
rs1000303933 -- 64,083,516(+) CTGGG(A/G)TCCGG intron-variant, upstream-variant-2KB, reference, missense
rs1000325653 -- 64,097,192(+) TTAAT(-/CAC)CAACG intron-variant
rs1000348314 -- 64,089,464(+) CCCCT(C/T)CTTTC intron-variant, upstream-variant-2KB
rs1000441807 -- 64,096,591(+) TCCCT(C/T)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRL1 Gene

Variant ID Type Subtype PubMed ID
dgv1259e212 CNV gain 25503493
dgv2296n106 CNV deletion 24896259
dgv4345n100 CNV gain 25217958
dgv4346n100 CNV loss 25217958
dgv710n67 CNV gain 20364138
dgv7701n54 CNV loss 21841781
dgv7702n54 CNV gain 21841781
dgv7703n54 CNV gain+loss 21841781
dgv7704n54 CNV gain 21841781
dgv7705n54 CNV loss 21841781
dgv7706n54 CNV gain 21841781
dgv7707n54 CNV loss 21841781
dgv7708n54 CNV gain+loss 21841781
dgv7709n54 CNV gain 21841781
dgv7710n54 CNV loss 21841781
dgv7711n54 CNV loss 21841781
dgv7712n54 CNV gain+loss 21841781
dgv7713n54 CNV loss 21841781
dgv7714n54 CNV loss 21841781
dgv7715n54 CNV loss 21841781
esv1182210 CNV insertion 17803354
esv1344965 CNV insertion 17803354
esv2580034 CNV insertion 19546169
esv26753 CNV gain 19812545
esv2758807 CNV gain+loss 17122850
esv3058235 CNV deletion 24192839
nsv1073089 CNV deletion 25765185
nsv1073090 CNV deletion 25765185
nsv1132903 CNV insertion 24896259
nsv1142314 CNV tandem duplication 24896259
nsv428381 CNV gain+loss 18775914
nsv470564 CNV gain 18288195
nsv509785 CNV insertion 20534489
nsv586703 CNV loss 21841781
nsv586732 CNV loss 21841781
nsv586753 CNV gain 21841781
nsv586762 CNV gain 21841781
nsv586770 CNV loss 21841781
nsv586772 CNV gain+loss 21841781
nsv586785 CNV loss 21841781
nsv586792 CNV loss 21841781
nsv586805 CNV gain 21841781
nsv586806 CNV loss 21841781
nsv586808 CNV loss 21841781
nsv586809 CNV loss 21841781
nsv586810 CNV loss 21841781
nsv953310 CNV deletion 24416366

Variation tolerance for OPRL1 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRL1 Gene

Human Gene Mutation Database (HGMD)
OPRL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRL1 Gene

Disorders for OPRL1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for OPRL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
drug dependence
pain agnosia
  • analgesia
agnosia
  • dyspraxia
alcohol dependence
  • alcohol dependence, protection against
specific developmental disorder
- elite association - COSMIC cancer census association via MalaCards
Search OPRL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRL1

Genetic Association Database (GAD)
OPRL1
Human Genome Epidemiology (HuGE) Navigator
OPRL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRL1
genes like me logo Genes that share disorders with OPRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRL1 Gene

Publications for OPRL1 Gene

  1. Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (PMID: 17910740) Xuei X. … Edenberg H.J. (Addict Biol 2008) 2 3 22 46 64
  2. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. (PMID: 8137918) Mollereau C. … Meunier C. (FEBS Lett. 1994) 2 3 4 22 64
  3. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. (PMID: 20032820) Briant J.A. … Kreek M.J. (Psychiatr. Genet. 2010) 3 22 46 64
  4. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. (PMID: 18269382) Huang J. … Wahlestedt C. (Addict Biol 2008) 3 22 46 64
  5. No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort. (PMID: 15276231) Pritchard A. … Lendon C. (Neurosci. Lett. 2004) 3 22 46 64

Products for OPRL1 Gene

  • Addgene plasmids for OPRL1

Sources for OPRL1 Gene

Content
Loading form....