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Aliases for OPRK1 Gene

Aliases for OPRK1 Gene

  • Opioid Receptor Kappa 1 2 3
  • Opioid Receptor, Kappa 1 2 3 5
  • K-OR-1 3 4
  • KOR-1 3 4
  • OPRK 3 4
  • Opiate Receptor, Kappa-1 3
  • Kappa Opioid Receptor 3
  • KOR 3

External Ids for OPRK1 Gene

Previous GeneCards Identifiers for OPRK1 Gene

  • GC08M053424
  • GC08M054146
  • GC08M053864
  • GC08M054191
  • GC08M054304
  • GC08M049605
  • GC08M054138

Summaries for OPRK1 Gene

Entrez Gene Summary for OPRK1 Gene

  • This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]

GeneCards Summary for OPRK1 Gene

OPRK1 (Opioid Receptor Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include alcohol dependence and phobic disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and opioid receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRK1 Gene

  • G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Tocris Summary for OPRK1 Gene

  • The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor (designated kappa1, kappa2, and kappa3) have been characterized.

Gene Wiki entry for OPRK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRK1 Gene

Genomics for OPRK1 Gene

Regulatory Elements for OPRK1 Gene

Genomic Location for OPRK1 Gene

Chromosome:
8
Start:
53,225,716 bp from pter
End:
53,251,697 bp from pter
Size:
25,982 bases
Orientation:
Minus strand

Genomic View for OPRK1 Gene

Genes around OPRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRK1 Gene

Proteins for OPRK1 Gene

  • Protein details for OPRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41145-OPRK_HUMAN
    Recommended name:
    Kappa-type opioid receptor
    Protein Accession:
    P41145
    Secondary Accessions:
    • E5RHC9
    • Q499G4

    Protein attributes for OPRK1 Gene

    Size:
    380 amino acids
    Molecular mass:
    42645 Da
    Quaternary structure:
    • Interacts with SLC9A3R1. Interacts with GABARAPL1.

    Three dimensional structures from OCA and Proteopedia for OPRK1 Gene

    Alternative splice isoforms for OPRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRK1 Gene

Proteomics data for OPRK1 Gene at MOPED

Post-translational modifications for OPRK1 Gene

  • Glycosylation at Asn 25 and Asn 39
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for OPRK1 Gene

Domains & Families for OPRK1 Gene

Gene Families for OPRK1 Gene

Suggested Antigen Peptide Sequences for OPRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41145

UniProtKB/Swiss-Prot:

OPRK_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRK1: view

Function for OPRK1 Gene

Molecular function for OPRK1 Gene

GENATLAS Biochemistry:
opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G protein-modulated K+ channel
UniProtKB/Swiss-Prot Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
genes like me logo Genes that share phenotypes with OPRK1: view

Animal Models for OPRK1 Gene

MGI Knock Outs for OPRK1:

Animal Model Products

miRNA for OPRK1 Gene

miRTarBase miRNAs that target OPRK1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRK1 Gene

Localization for OPRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRK1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRK1 Gene COMPARTMENTS Subcellular localization image for OPRK1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IDA 22437504
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with OPRK1: view

Pathways & Interactions for OPRK1 Gene

genes like me logo Genes that share pathways with OPRK1: view

Pathways by source for OPRK1 Gene

Gene Ontology (GO) - Biological Process for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 8755601
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS --
GO:0007268 synaptic transmission TAS 7624359
GO:0007600 sensory perception TAS 7624359
GO:0007610 behavior TAS 7624359
genes like me logo Genes that share ontologies with OPRK1: view

No data available for SIGNOR curated interactions for OPRK1 Gene

Drugs & Compounds for OPRK1 Gene

(138) Drugs for OPRK1 Gene - From: Novoseek, IUPHAR, DGIdb, DrugBank, ApexBio, HMDB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 855
Nalbuphine Approved Pharma Full agonist, Agonist, antagonist, Target, agonist 25
Naloxone Approved Pharma Antagonist, antagonist, Target 221
Naltrexone Approved, Investigational Pharma Antagonist, antagonist, Target 349
Fentanyl Approved, Illicit, Investigational Pharma Full agonist, Agonist, agonist, Target 705

(64) Additional Compounds for OPRK1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-EKC
Full agonist, Agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]CI977
alpha-neoendorphin
Full agonist, Agonist
beta-FNA
Antagonist
genes like me logo Genes that share compounds with OPRK1: view

Drug Products

Transcripts for OPRK1 Gene

mRNA/cDNA for OPRK1 Gene

Unigene Clusters for OPRK1 Gene

Opioid receptor, kappa 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRK1 Gene

No ASD Table

Relevant External Links for OPRK1 Gene

GeneLoc Exon Structure for
OPRK1
ECgene alternative splicing isoforms for
OPRK1

Expression for OPRK1 Gene

mRNA expression in normal human tissues for OPRK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRK1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x9.3), Brain - Hypothalamus (x7.1), Brain - Amygdala (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.9), and Brain - Caudate (basal ganglia) (x4.7).

Protein differential expression in normal tissues from HIPED for OPRK1 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPRK1 Gene



SOURCE GeneReport for Unigene cluster for OPRK1 Gene Hs.106795

mRNA Expression by UniProt/SwissProt for OPRK1 Gene

P41145-OPRK_HUMAN
Tissue specificity: Detected in brain and placenta.
genes like me logo Genes that share expression patterns with OPRK1: view

Protein tissue co-expression partners for OPRK1 Gene

Primer Products

In Situ Assay Products

Orthologs for OPRK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRK1 35
  • 96.64 (n)
  • 96.54 (a)
OPRK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPRK1 36
  • 94 (a)
OneToOne
OPRK1 35
  • 89.04 (n)
  • 93.68 (a)
dog
(Canis familiaris)
Mammalia OPRK1 35
  • 90.26 (n)
  • 92.89 (a)
OPRK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprk1 16
Oprk1 36
  • 94 (a)
OneToOne
Oprk1 35
  • 86.67 (n)
  • 93.68 (a)
oppossum
(Monodelphis domestica)
Mammalia OPRK1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRK1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprk1 35
  • 86.93 (n)
  • 94.21 (a)
chicken
(Gallus gallus)
Aves OPRK1 35
  • 77.02 (n)
  • 85.79 (a)
OPRK1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRK1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprk1 35
  • 68.82 (n)
  • 79.3 (a)
zebrafish
(Danio rerio)
Actinopterygii oprk1 36
  • 69 (a)
OneToOne
oprk1 35
  • 68.64 (n)
  • 70.43 (a)
Species with no ortholog for OPRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRK1 Gene

ENSEMBL:
Gene Tree for OPRK1 (if available)
TreeFam:
Gene Tree for OPRK1 (if available)

Paralogs for OPRK1 Gene

genes like me logo Genes that share paralogs with OPRK1: view

Variants for OPRK1 Gene

Sequence variations from dbSNP and Humsavar for OPRK1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs9282808 - 53,229,320(-) ACATC(A/C/G)ATGGG reference, missense
rs958170 -- 53,239,868(+) TCTTA(A/C/G)AAATA intron-variant
rs997917 -- 53,239,818(+) AGATA(C/T)CACTG intron-variant
rs702764 -- 53,229,597(+) AAGAC(C/G/T)GCCAC reference, synonymous-codon
rs2303432 -- 53,244,657(-) TTTGT(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRK1 Gene

Variant ID Type Subtype PubMed ID
nsv6193 CNV Insertion 18451855
esv260063 OTHER Complex 20981092
nsv397858 CNV Insertion 16902084
nsv438054 CNV Loss 16468122
nsv6194 CNV Insertion 18451855

Variation tolerance for OPRK1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRK1 Gene

HapMap Linkage Disequilibrium report
OPRK1
Human Gene Mutation Database (HGMD)
OPRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRK1 Gene

Disorders for OPRK1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for OPRK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcohol dependence, protection against
phobic disorder
  • phobic anxiety disorder
drug dependence
  • substance dependence
substance dependence
cocaine dependence
- elite association - COSMIC cancer census association via MalaCards
Search OPRK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRK1

Genetic Association Database (GAD)
OPRK1
Human Genome Epidemiology (HuGE) Navigator
OPRK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRK1
genes like me logo Genes that share disorders with OPRK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRK1 Gene

Publications for OPRK1 Gene

  1. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. (PMID: 17373729) Gerra G. … Donnini C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48 67
  2. Oxycodone: a review of its use in the management of pain. (PMID: 18039433) Riley J. … Arendt-Nielsen L. (Curr Med Res Opin 2008) 23 25 26
  3. Levorphanol: the forgotten opioid. (PMID: 17039381) Prommer E. (Support Care Cancer 2007) 23 25 26
  4. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors. (PMID: 17407276) Peng X. … Neumeyer J.L. (J. Med. Chem. 2007) 23 25 26
  5. Pharmacological profiles of opioid ligands at kappa opioid receptors. (PMID: 16433932) Gharagozlou P. … Lameh J. (BMC Pharmacol. 2006) 23 25 26

Products for OPRK1 Gene

Sources for OPRK1 Gene

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