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Aliases for OPRK1 Gene

Aliases for OPRK1 Gene

  • Opioid Receptor, Kappa 1 2 3
  • K-OR-1 3 4
  • KOR-1 3 4
  • OPRK 3 4
  • Kappa-Type Opioid Receptor 3
  • Opiate Receptor, Kappa-1 3
  • Kappa Opioid Receptor 3
  • KOR 3

External Ids for OPRK1 Gene

Previous GeneCards Identifiers for OPRK1 Gene

  • GC08M053424
  • GC08M054146
  • GC08M053864
  • GC08M054191
  • GC08M054304
  • GC08M049605
  • GC08M054138

Summaries for OPRK1 Gene

GeneCards Summary for OPRK1 Gene

OPRK1 (Opioid Receptor, Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include morphine dependence and uremic pruritus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include opioid receptor activity and dynorphin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRK1 Gene

  • G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Tocris Summary for OPRK1 Gene

  • The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor designated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptor protein with other membrane associated proteins. kappa Opioid receptors are located predominantly in the cerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation of nociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphin appear to be the endogenous ligands. The human gene encoding the kappa opioid receptor has been localized to chromosome 8 (8q11.2).

Gene Wiki entry for OPRK1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRK1 Gene

Genomics for OPRK1 Gene

Regulatory Elements for OPRK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OPRK1 Gene

Start:
53,225,716 bp from pter
End:
53,251,697 bp from pter
Size:
25,982 bases
Orientation:
Minus strand

Genomic View for OPRK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRK1 Gene

Proteins for OPRK1 Gene

  • Protein details for OPRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41145-OPRK_HUMAN
    Recommended name:
    Kappa-type opioid receptor
    Protein Accession:
    P41145
    Secondary Accessions:
    • E5RHC9
    • Q499G4

    Protein attributes for OPRK1 Gene

    Size:
    380 amino acids
    Molecular mass:
    42645 Da
    Quaternary structure:
    • Interacts with SLC9A3R1. Interacts with GABARAPL1.

    Three dimensional structures from OCA and Proteopedia for OPRK1 Gene

    Alternative splice isoforms for OPRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRK1 Gene

Proteomics data for OPRK1 Gene at MOPED

Post-translational modifications for OPRK1 Gene

  • Glycosylation at Asn25 and Asn39
  • Modification sites at PhosphoSitePlus

Other Protein References for OPRK1 Gene

Antibody Products

No data available for DME Specific Peptides for OPRK1 Gene

Domains for OPRK1 Gene

Gene Families for OPRK1 Gene

HGNC:
  • OPR :GPCR / Class A : Opioid receptors
IUPHAR :

Suggested Antigen Peptide Sequences for OPRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41145

UniProtKB/Swiss-Prot:

OPRK_HUMAN :
  • P41145
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRK1: view

Function for OPRK1 Gene

Molecular function for OPRK1 Gene

GENATLAS Biochemistry: opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G protein-modulated K+ channel
UniProtKB/Swiss-Prot Function: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Gene Ontology (GO) - Molecular Function for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004985 opioid receptor activity IDA 22437504
GO:0005515 protein binding IPI 16431922
GO:0038048 dynorphin receptor activity IMP 7624359
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with OPRK1: view
genes like me logo Genes that share phenotypes with OPRK1: view

Animal Models for OPRK1 Gene

MGI Knock Outs for OPRK1:

Animal Model Products

CRISPR Products

miRNA for OPRK1 Gene

miRTarBase miRNAs that target OPRK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPRK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OPRK1 Gene

Localization for OPRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRK1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRK1 Gene COMPARTMENTS Subcellular localization image for OPRK1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 7624359
GO:0016021 integral component of membrane IDA 22437504
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with OPRK1: view

Pathways for OPRK1 Gene

genes like me logo Genes that share pathways with OPRK1: view

Pathways by source for OPRK1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 8755601
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 7624359
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with OPRK1: view

Compounds for OPRK1 Gene

(5) Tocris Compounds for OPRK1 Gene

Compound Action Cas Number
ICI 204,448 hydrochloride kappa agonist, acts peripherally [121264-04-8]
(�)-U-50488 hydrochloride Standard selective kappa agonist [67197-96-0]
(-)-U-50488 hydrochloride Standard selective kappa agonist. More active enantiomer of (�)-U-50488 (Cat. No. 0495) [114528-79-9]
Dynorphin A Endogenous kappa agonist [80448-90-4]
nor-Binaltorphimine dihydrochloride Standard kappa selective antagonist [113158-34-2]

(2) HMDB Compounds for OPRK1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Codeine
  • (-)-Codeine
76-57-3

(32) Drugbank Compounds for OPRK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Methylfentanyl
  • 3-MF
42045-86-3 target agonist
3-Methylthiofentanyl
86052-04-2 target agonist
Alvimopan
170098-38-1 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target agonist
Buprenorphine
  • Buprenophine
52485-79-7 target antagonist

(47) IUPHAR Ligand for OPRK1 Gene

Ligand Type Action Affinity Pubmed IDs
nor-binaltorphimine Antagonist Antagonist 11
dynorphin A Agonist Full agonist 10.8
dynorphin A-(1-13) Agonist Full agonist 10.7
(-)-bremazocine Agonist Partial agonist 10.5
buprenorphine Antagonist Antagonist 10.2
alpha-neoendorphin Agonist Full agonist 10.2
TRK820 Agonist Full agonist 10.1
(-)-EKC Agonist Full agonist 10
(-)-cyclazocine Agonist Partial agonist 10
dynorphin A-(1-8) Agonist Full agonist 9.9
GNTI Antagonist Antagonist 9.9
dynorphin B Agonist Partial agonist 9.9
U50488 Agonist Partial agonist 9.7
etorphine Agonist Full agonist 9.7
diprenorphine Antagonist Antagonist 9.7
dynorphin-(1-11) Agonist Full agonist 9.7
(-)-quadazocine Antagonist Antagonist 9.7
beta-FNA Antagonist Antagonist 9.7
GR 89696 Agonist Full agonist 9.7
naloxone benzoylhydrazone Agonist Partial agonist 9.5
U69593 Agonist Full agonist 9.5
nalmefene Antagonist Antagonist 9.5
EKC Agonist Full agonist 9.4
naltrexone Antagonist Antagonist 9.4
enadoline Agonist Full agonist 9.2
E2078 Agonist Full agonist 9.1
[3H]diprenorphine Antagonist Antagonist 9.1
nalorphine Agonist Partial agonist 9.1
[3H]U69593 Agonist Full agonist 8.8
tifluadom Agonist Full agonist 8.8
salvinorin A Agonist Full agonist 8.7
(-)-pentazocine Agonist Partial agonist 8.6
naloxone Antagonist Antagonist 8.6
BNTX Antagonist Antagonist 8.4
naltriben Antagonist Antagonist 8.4
naltrindole Antagonist Antagonist 8
beta-neoendorphin Agonist Full agonist 7.9
beta-endorphin Agonist Partial agonist 7.9
normorphine Agonist Full agonist 7.8
nalbuphine Agonist Full agonist 7.5
morphine Agonist Partial agonist 7.3
dihydromorphine Agonist Partial agonist 7.1
fentanyl Agonist Partial agonist 7.1
etonitazene Agonist Partial agonist 6.9
(-)-methadone Agonist Partial agonist 6.5
DAMGO Agonist Partial agonist 6.5
[3H]CI977 None None

(116) Novoseek inferred chemical compound relationships for OPRK1 Gene

Compound -log(P) Hits PubMed IDs
norbinaltorphimine 93.7 65
salvinorin a 92.2 52
u69593 89.2 9
enadoline 87.6 7
u50488 86.9 21
genes like me logo Genes that share compounds with OPRK1: view

Transcripts for OPRK1 Gene

mRNA/cDNA for OPRK1 Gene

Unigene Clusters for OPRK1 Gene

Opioid receptor, kappa 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPRK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OPRK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPRK1 Gene

No ASD Table

Relevant External Links for OPRK1 Gene

GeneLoc Exon Structure for
OPRK1
ECgene alternative splicing isoforms for
OPRK1

Expression for OPRK1 Gene

mRNA expression in normal human tissues for OPRK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRK1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (9.3), Brain - Hypothalamus (7.1), Brain - Amygdala (5.3), Brain - Anterior cingulate cortex (BA24) (4.9), and Brain - Caudate (basal ganglia) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OPRK1 Gene

SOURCE GeneReport for Unigene cluster for OPRK1 Gene Hs.106795

mRNA Expression by UniProt/SwissProt for OPRK1 Gene

P41145-OPRK_HUMAN
Tissue specificity: Detected in brain and placenta.
genes like me logo Genes that share expressions with OPRK1: view

In Situ Assay Products

Orthologs for OPRK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRK1 35
  • 96.64 (n)
  • 96.54 (a)
OPRK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPRK1 35
  • 89.04 (n)
  • 93.68 (a)
OPRK1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRK1 35
  • 90.26 (n)
  • 92.89 (a)
OPRK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprk1 35
  • 86.67 (n)
  • 93.68 (a)
Oprk1 16
Oprk1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPRK1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPRK1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprk1 35
  • 86.93 (n)
  • 94.21 (a)
chicken
(Gallus gallus)
Aves OPRK1 35
  • 77.02 (n)
  • 85.79 (a)
OPRK1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRK1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprk1 35
  • 68.82 (n)
  • 79.3 (a)
zebrafish
(Danio rerio)
Actinopterygii oprk1 35
  • 68.64 (n)
  • 70.43 (a)
oprk1 36
  • 69 (a)
OneToOne
Species with no ortholog for OPRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRK1 Gene

ENSEMBL:
Gene Tree for OPRK1 (if available)
TreeFam:
Gene Tree for OPRK1 (if available)

Paralogs for OPRK1 Gene

genes like me logo Genes that share paralogs with OPRK1: view

Variants for OPRK1 Gene

Sequence variations from dbSNP and Humsavar for OPRK1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs702764 -- 53,229,597(+) AAGAC(C/T)GCCAC reference, synonymous-codon
rs768345 -- 53,237,592(-) ctata(G/T)aataa intron-variant
rs958170 -- 53,239,868(+) TCTTA(A/C/G)AAATA intron-variant
rs963549 -- 53,229,264(+) CTTCC(C/T)GAAGA utr-variant-3-prime
rs976303 -- 53,234,646(+) TTTCC(A/G)TCGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRK1 Gene

Variant ID Type Subtype PubMed ID
nsv6193 CNV Insertion 18451855
esv260063 OTHER Complex 20981092
nsv397858 CNV Insertion 16902084
nsv438054 CNV Loss 16468122
nsv6194 CNV Insertion 18451855

Relevant External Links for OPRK1 Gene

HapMap Linkage Disequilibrium report
OPRK1
Human Gene Mutation Database (HGMD)
OPRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRK1 Gene

Disorders for OPRK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (8) Diseases for OPRK1 Gene including...

Search for OPRK1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for OPRK1 Gene

(35) Novoseek inferred disease relationships for OPRK1 Gene

Disease -log(P) Hits PubMed IDs
opioid dependence 54.2 2
respiratory depression 48.4 1
cocaine abuse 38 1
cocaine dependence 32.5 1
drug dependence 27.4 2

Relevant External Links for OPRK1

Genetic Association Database (GAD)
OPRK1
Human Genome Epidemiology (HuGE) Navigator
OPRK1
genes like me logo Genes that share disorders with OPRK1: view

No data available for UniProtKB/Swiss-Prot for OPRK1 Gene

Publications for OPRK1 Gene

  1. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (PMID: 15608558) Yuferov V. … Kreek M.J. (Pharmacogenetics 2004) 3 23 48
  2. Association of the kappa-opioid system with alcohol dependence. (PMID: 16924269) Xuei X. … Edenberg H.J. (Mol. Psychiatry 2006) 3 23 48
  3. A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. (PMID: 18319328) Edenberg H.J. … Foroud T. (Hum. Mol. Genet. 2008) 3 23 48
  4. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. (PMID: 17373729) Gerra G. … Donnini C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  5. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. (PMID: 17374034) Gelernter J. … Krystal J.H. (Alcohol. Clin. Exp. Res. 2007) 3 23 48

Products for OPRK1 Gene

  • Addgene plasmids for OPRK1

Sources for OPRK1 Gene

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