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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPRK1 Gene

protein-coding   GIFtS: 65
GCID: GC08M054138

opioid receptor, kappa 1
 Explore 36 diseases affiliated with
OPRK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OPRK1    

Aliases
for OPRK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Opioid Receptor, Kappa 11 2     OPRK2 3
KOR1 2     Kappa Opioid Receptor2
K-OR-12 3     Kappa-Type Opioid Receptor2
KOR-12 3     Opiate Receptor, Kappa-12

External Ids:    HGNC: 81541   Entrez Gene: 49862   Ensembl: ENSG000000825567   OMIM: 1651965   UniProtKB: P411453   

Export aliases for OPRK1 gene to outside databases

Previous GC identifers: GC08M053424 GC08M054146 GC08M053864 GC08M054191 GC08M054304 GC08M049605


Summaries
for OPRK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions

summary for OPRK1:
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of
G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor
designated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has been
identified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptor
protein with other membrane associated proteins. kappa Opioid receptors are located predominantly in the
cerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation of
nociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphin
appear to be the endogenous ligands. The human gene encoding the kappa opioid receptor has been localized to
chromosome 8 (8q11.2).

Gene Wiki entry for OPRK1 (Kappa Opioid receptor)


Genomic Views
for OPRK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPRK1 gene promoter:
         Max1   Sp1   AP-1   ATF-2   FOXD3   Nkx2-5   MZF-1   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OPRK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OPRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.2   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.2

OPRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRK1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M054138:  view genomic region     (about GC identifiers)

Start:
 54,138,276 bp from pter      End:
 54,164,257 bp from pter
Size:
 25,982 bases      Orientation:
 minus strand

Proteins
for OPRK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145 (See protein sequence)
Recommended Name: Kappa-type opioid receptor  
Size: 380 amino acids; 42645 Da
Subunit: Interacts with SLC9A3R1. Interacts with GABARAPL1
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for OPRK1:
2A0D (3D)        2IQN (3D)        4DJH (3D)    
Secondary accessions: Q499G4

Explore the universe of human proteins at neXtProt for OPRK1: NX_P41145

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41145

    • OPRK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000903.2  
    ENSEMBL proteins: 
     ENSP00000265572   ENSP00000428231   ENSP00000430923   ENSP00000429706  
    Reactome Protein details: P41145
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant OPRK1 Protein
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    OriGene Protein Over-expression Lysate: OPRK1
    OriGene Custom Protein Services for OPRK1 
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    Novus Biologicals OPRK1 Proteins
    Novus Biologicals OPRK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7624359
    GO:0016021integral to membrane ----


    OPRK1 for ontologies           About GeneDecksing



    OPRK1 Antibody Products: 
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    ThermoFisher Antibodies for OPRK1

    Assay Products for OPRK1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for OPRK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OPRK1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000452 Kappa_opi_rcpt
     IPR001418 Opioid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41145

    ProtoNet protein and cluster: P41145

    2 Blocks protein families:
    IPB000452 Kappa opioid receptor signature
    IPB001418 Opioid receptor signature


    UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for OPRK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
    Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
    Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions

         Genatlas biochemistry entry for OPRK1:
    opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G protein-modulated K+
    channel

    miRNA
    Products:            		 OriGene 3'-UTR Clone: OPRK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPRK1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate OPRK1 (see all 26):
    hsa-miR-623 hsa-miR-3200-5p hsa-miR-188-5p hsa-miR-509-5p hsa-miR-885-5p hsa-miR-181a-2* hsa-miR-520a-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: OPRK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPRK1 (see all 7)
    OriGene shRNA RFP: OPRK1
    OriGene siRNA: OPRK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPRK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OPRK1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPRK1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPRK1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OPRK1 (NM_000912)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPRK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for OPRK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRK1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16431922
    GO:0038048dynorphin receptor activity IDA8755601


    OPRK1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for OPRK1: Oprk1tm1Kff Oprk1tm1Jep
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Oprk1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  integument  reproductive system 

    OPRK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for OPRK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46
    4DREAM Repression and Dynorphin Expression
    		DREAM Repression and Dynorphin Expression1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for OPRK1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for OPRK1
        DREAM Repression and Dynorphin Expression

    2 BioSystems Pathways for OPRK1 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for OPRK1 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for OPRK1):
        Neuroactive ligand-receptor interaction


    OPRK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/149 Interacting proteins for OPRK1 (P411451, 2, 3 ENSP000002655724) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-58245 I2D: score=3 STRING: ENSP00000262613
    GABARAPL1Q9H0R81, 3, ENSP000002664584EBI-925028,EBI-3240381 I2D: score=3 STRING: ENSP00000266458
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    OPRD1P411433, ENSP000002349614I2D: score=1 STRING: ENSP00000234961
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IDA8755601
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS7624359
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ISS--
    GO:0007268synaptic transmission TAS7624359
    GO:0007600sensory perception TAS7624359


    OPRK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OPRK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OPRK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for OPRK1

    Compounds for OPRK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (±)-U-50488 hydrochlorideStandard selective kappa agonist[67198-13-4]
    N-MPPP HydrochlorideSelective kappa agonist[207452-97-9]
    BRL 52537 hydrochloridePotent and selective kappa agonist[130497-33-5]
    Salvinorin AHighly potent and selective kappa-opioid agonist[83729-01-5]
    ICI 199,441 hydrochloride Potent kappa agonist[115199-84-3]

    2 HMDB Compounds for OPRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Codeine(-)-Codeine (see all 9)76-57-3--

    10/30 DrugBank Compounds for OPRK1 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ButorphanolButorfanol (see all 4)58786-99-5targetagonist7705457 12127012 12470863 10779697 2555580 10381785 17909753 8746803 15942128 8968334
    Nalbuphine-- 20594-83-6targetagonist15655510 16517095 15602503 17139284 17407276 10534607 17016423 8388112 19403853
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2targetagonist7959748 17139284 16753266 9808678 17016423
    Naltrexone-- 16590-41-3targetantagonist18354714 9040115 11752352 19484223 17661275
    CodeineCodeine anhydrous (see all 6)76-57-3targetpartial agonist7885194 17139284 17016423 17620111
    DezocineDezocina [INN-Spanish] (see all 2)53648-55-8targetantagonist16433932 17139284 11752352 17016423
    3-Methylfentanyl3-MF (see all 3)42045-86-3targetagonist8576134 6264594 8030414
    Dihydromorphine-- 509-60-4targetagonist15178355 19474215 16777416
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist16433932 17720886 7739347
    HydromorphoneDihydromorfinon [Czech] (see all 7)466-99-9targetagonist16433932 17139284 17016423

    10/116 Novoseek chemical compound relationships for OPRK1 gene (see all 116)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norbinaltorphimine 93.7 95 7851478 (3), 12915238 (2), 7541509 (2), 10448921 (2) (see all 58)
    salvinorin a 92.2 67 14718611 (5), 17951511 (5), 19555087 (4), 12628350 (4) (see all 25)
    u69593 89.2 14 2176574 (2), 10669040 (2), 10448921 (2), 10440101 (1) (see all 6)
    enadoline 87.6 8 10448921 (2), 1316755 (1), 8867523 (1), 8627579 (1) (see all 6)
    u50488 86.9 25 9744578 (2), 12626643 (2), 10665828 (2), 12473373 (2) (see all 15)
    bremazocine 86.4 13 9833011 (3), 12915238 (2), 16007240 (2), 10448921 (2) (see all 8)
    [3h]diprenorphine 85.4 9 11076532 (2), 8387137 (1), 16006595 (1), 16505160 (1) (see all 6)
    cyclorphan 85.3 2 17433695 (1), 17276685 (1)
    morphinan 84.3 4 19634902 (1), 15542743 (1), 16076937 (1)
    tifluadom 83.7 1 11579457 (1)

    Search CenterWatch for drugs/clinical trials and news about OPRK1 / OPRK 

    Transcripts
    for OPRK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OPRK1 gene: 
    NM_000912.3  

    Unigene Cluster for OPRK1:

    Opioid receptor, kappa 1
    Hs.106795  [show with all ESTs]
    Unigene Representative Sequence: NM_000912
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265572(uc022aup.1 uc003xrh.1 uc003xri.1 uc010lyc.1)
    ENST00000522508 ENST00000524278 ENST00000520287

    miRNA
    Products:             		 OriGene 3'-UTR Clone: OPRK1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPRK1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate OPRK1 (see all 26):
    hsa-miR-623 hsa-miR-3200-5p hsa-miR-188-5p hsa-miR-509-5p hsa-miR-885-5p hsa-miR-181a-2* hsa-miR-520a-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: OPRK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPRK1 (see all 7)
    OriGene shRNA RFP: OPRK1
    OriGene siRNA: OPRK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPRK1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPRK1
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    GenScript: all cDNA clones in your preferred vector: OPRK1 (NM_000912)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRK1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPRK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPRK1

    Additional cDNA sequence: 

    AF498922.1 AK023198.1 AK310233.1 AK310407.1 AK313058.1 AY168006.1 AY466378.1 BC099912.1 
    EF057067.1 L36130.1 L37362.1 U11053.1 U17298.1 

    4 DOTS entries:

    DT.100016314  DT.108243  DT.121472989  DT.101962844 

    15 AceView cDNA sequences:

    U17298 BX092912 NM_000912 AY466378 CF593603 AY168006 AF498922 CB565888 
    L36130 L37362 U11053 R81583 R81332 R31984 R31938 

    GeneLoc Exon Structure


    Expression
    for OPRK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAATTCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See OPRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPRK1

    SOURCE GeneReport for Unigene cluster: Hs.106795
        SABiosciences Expression via Pathway-Focused PCR Arrays including OPRK1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPRK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRK1

    Orthologs
    for OPRK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OPRK1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OPRK11 opioid receptor, kappa 1 77.02(n)
    85.79(a)    		   428533  XM_426087.2  XP_426087.2 
    lizard
    (Anolis carolinensis)    		 Reptilia OPRK16
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343244.1(1369263-1390821)
    zebrafish
    (Danio rerio)    		 Actinopterygii oprk12 opioid receptor, kappa 1 79.65(n)   360139  AF285173.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta star16
    AlCR26
    		 allatostatin C receptor 2
    		 22(a)
    19(a)
    		 many ↔ many
    many ↔ many
    		 3L(18553358-18569426)
    3L(18478237-18495657)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54E2A.16
    		 --
    		 12(a)
    		 possible ortholog
    		 II(14734335-14739167)


    ENSEMBL Gene Tree for OPRK1 (if available)
    TreeFam Gene Tree for OPRK1 (if available) 

    Paralogs
    for OPRK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPRK1 gene
    SSTR32  OPRD12  SSTR42  GALR22  MCHR22  SSTR12  GALR32  OPRL12  
    NPBWR12  KISS1R2  GALR12  SSTR52  SSTR22  MCHR12  NPBWR22  OPRM12  
    18/49 SIMAP similar genes for OPRK1 using alignment to 3 protein entries:     OPRK_HUMAN (see all proteins) (see all similar genes):
    OPRM1    OPRD1    OPRL1    OPRMI    GPR18    NPBWR2
    P2RY4    SSTR4    SSTR1    F2RL1    SSTR2    CCR-5
    NPBWR1    SSTR5    CCR3    CX3CR1    CXCR2    SSTR3

    OPRK1 for paralogs           About GeneDecksing



    Genomic Variants
    for OPRK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 NCBI SNPs in OPRK1 are shown (see all 810)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1998595641,2
    		C--54137780(+) TTTGTA/GTGTAA 1 -- ds50010--------
    rs736796841,2
    		C,F,--54137793(+) TACTAT/CGCGGT 1 -- ds50013Minor allele frequency- C:0.06WA CSA 122
    rs1450122591,2
    		--54137795(+) CTATGA/CGGTTT 1 -- ds50010--------
    rs736796851,2
    		C,--54137796(+) TATGCG/AGTTTA 1 -- ds50012Minor allele frequency- A:0.06WA 120
    rs1491543661,2
    		--54137961(+) GATTTC/TCATTG 1 -- ds50010--------
    rs1870976181,2
    		--54137969(+) TTGTGA/GGAGCA 1 -- ds50010--------
    rs1432917511,2
    		--54138190(+) CCTTAC/TAGTTT 1 -- ds50010--------
    rs736796861,2
    		C,F,--54138218(+) TGTTCT/CTGCTG 1 -- ds50013Minor allele frequency- C:0.06WA CSA 122
    rs169188351,2
    		C,F,--54138232(+) TGCAGC/TATCAC 1 -- ds500111Minor allele frequency- T:0.22NA WA CSA EA 510
    rs119920221,2
    		C,F,A,H,--54138291(+) ATTTTC/TAGCAG 1 -- ut3111Minor allele frequency- N:0.00EA NA WA CSA 582

    HapMap Linkage Disequilibrium report for OPRK1 (54138276 - 54164257 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OPRK1
         1 CNV: 1782
    Human Gene Mutation Database (HGMD): OPRK1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for OPRK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OPRK1 for disorders           About GeneDecksing

    OMIM gene information: 165196    OMIM disorders: --

    20/36 diseases for OPRK1 (see all 36):    About MalaCards
    morphine dependence    cocaine abuse    cocaine dependence    drug dependence
    autism spectrum disorder    substance dependence    anorexia nervosa    agoraphobia
    megakaryocytic leukemia    alcohol dependence    atopic dermatitis    acute lymphoblastic leukemia
    rheumatoid arthritis    lymphoblastic leukemia    brain disease    parkinson's disease
    alcoholism    embryonal carcinoma    alzheimer's disease    osteoarthritis

    3 diseases from the University of Copenhagen DISEASES database for OPRK1:
    Agoraphobia     Pain agnosia     Alcohol dependence

    10/35 Novoseek disease relationships for OPRK1 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    opioid dependence 54.2 3 9365966 (1), 9517399 (1)
    respiratory depression 48.4 1 19833235 (1)
    cocaine abuse 38 1 19253970 (1)
    cocaine dependence 32.5 1 15988468 (1)
    drug dependence 27.4 3 15542743 (2)
    morphine dependence 24.1 1 8544279 (1)
    brain diseases 20.5 6 9030693 (2), 9874464 (1), 12473373 (1), 7746504 (1) (see all 5)
    drug addiction 16.1 1 9729284 (1)
    hyperalgesia 8.73 1 15037816 (1)
    glioma 7.2 8 10646507 (3), 9918595 (2), 9874464 (1), 19828880 (1)

    Genetic Association Database (GAD): OPRK1
    Human Genome Epidemiology (HuGE) Navigator: OPRK1 (20 documents)

    Export disorders for OPRK1 gene to outside databases

    Publications
    for OPRK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPRK1 gene, integrated from 9 sources (see all 567):
    (articles sorted by number of sources associating them with OPRK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (PubMed id 15608558)1, 4, 9 Yuferov V....Kreek M.J. (2004)
    2. Structure of the human kappa-opioid receptor in complex with JDTic. (PubMed id 22437504)1, 2 Wu H.... Stevens R.C. (2012)
    3. N-glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. (PubMed id 17711303)1, 2 Li J.G.... Liu-Chen L.Y. (2007)
    4. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. (PubMed id 16431922)1, 2 Chen C....Liu-Chen L.Y. (2006)
    5. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. (PubMed id 14745298)1, 4 Loh e.l. . . . . . . . . . . .W....Cheng A.T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down- regulation of the human kappa opioid receptor by enhancing its recycling rate. (PubMed id 12004055)1, 2 Li J.-G.... Liu-Chen L.-Y. (2002)
    8. Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. (PubMed id 7624359)1, 2 Simonin F.... Kieffer B. (1995)
    9. Cloning of a human kappa opioid receptor from the brain. (PubMed id 7869844)1, 2 Zhu J.... Liu-Chen L.-Y. (1995)
    10. Isolation of a human kappa opioid receptor cDNA from placenta. (PubMed id 8060324)1, 2 Mansson E.... Yang D. (1994)

    External Searches for OPRK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OPRK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4986 HGNC: 8154 AceView: OPRK1 Ensembl:ENSG00000082556 euGenes: HUgn4986
    ECgene: OPRK1 Kegg: 4986 H-InvDB: OPRK1

    Other Databases showing OPRK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OPRK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPRK1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Kappa_opioid_receptor

    Intellectual Property
    for OPRK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OPRK1 gene:
    Search GeneIP for patents involving OPRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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