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OPRK1 Gene

protein-coding   GIFtS: 68
GCID: GC08M054138

Opioid Receptor, Kappa 1

  See OPRK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opioid Receptor, Kappa 11 2     KOR2
K-OR-12 3     Kappa Opioid Receptor2
KOR-12 3     Kappa-Type Opioid Receptor2
OPRK2 3     Opiate Receptor, Kappa-12

External Ids:    HGNC: 81541   Entrez Gene: 49862   Ensembl: ENSG000000825567   OMIM: 1651965   UniProtKB: P411453   

Export aliases for OPRK1 gene to outside databases

Previous GC identifers: GC08M053424 GC08M054146 GC08M053864 GC08M054191 GC08M054304 GC08M049605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OPRK1 Gene:
OPRK1 (opioid receptor, kappa 1) is a protein-coding gene. Diseases associated with OPRK1 include uremic pruritus, and morphine dependence. GO annotations related to this gene include dynorphin receptor activity and opioid receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
Function: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and
dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids
and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits
neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role
in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic
opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in
arousal and regulation of autonomic and neuroendocrine functions

summary for OPRK1 Gene:
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of
G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor
designated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has been
identified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptor
protein with other membrane associated proteins. kappa Opioid receptors are located predominantly in the
cerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation of
nociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphin
appear to be the endogenous ligands. The human gene encoding the kappa opioid receptor has been localized to
chromosome 8 (8q11.2).

Gene Wiki entry for OPRK1 (Kappa Opioid receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPRK1 gene promoter:
         Max1   Sp1   AP-1   ATF-2   FOXD3   Nkx2-5   MZF-1   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRK1 promoter sequence
   Search Chromatin IP Primers for OPRK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.2   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.2

OPRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRK1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M054138:  view genomic region     (about GC identifiers)

Start:
54,138,276 bp from pter      End:
54,164,257 bp from pter
Size:
25,982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145 (See protein sequence)
Recommended Name: Kappa-type opioid receptor  
Size: 380 amino acids; 42645 Da
Subunit: Interacts with SLC9A3R1. Interacts with GABARAPL1
3 PDB 3D structures from and Proteopedia for OPRK1:
2A0D (3D)        2IQN (3D)        4DJH (3D)    
Secondary accessions: E5RHC9 Q499G4

Explore the universe of human proteins at neXtProt for OPRK1: NX_P41145

Explore proteomics data for OPRK1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn39
  • Modification sites at PhosphoSitePlus

  • See OPRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000903.2  NP_001269833.1  

    ENSEMBL proteins: 
     ENSP00000265572   ENSP00000428231   ENSP00000430923   ENSP00000429706  
    Reactome Protein details: P41145

    OPRK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant OPRK1 Protein
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    Novus Biologicals OPRK1 Proteins
    Novus Biologicals OPRK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for OPRK1 

     
    antibodies-online proteins for OPRK1 (4 products) 

     
    antibodies-online peptides for OPRK1

    OPRK1 Antibody Products:

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    antibodies-online antibodies for OPRK1 (84 products) 

    OPRK1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for OPRK1 
    antibodies-online kits for OPRK1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPR: GPCR / Class A : Opioid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: kappa receptor
    Opioid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000452 Kappa_opi_rcpt
     IPR001418 Opioid_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41145

    ProtoNet protein and cluster: P41145

    2 Blocks protein domains:
    IPB000452 Kappa opioid receptor signature
    IPB001418 Opioid receptor signature


    UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OPRK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRK_HUMAN, P41145
    Function: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and
    dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids
    and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits
    neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role
    in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic
    opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in
    arousal and regulation of autonomic and neuroendocrine functions

         Genatlas biochemistry entry for OPRK1:
    opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G
    protein-modulated K+ channel

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004985opioid receptor activity IDA--
    GO:0005515protein binding IPI16431922
    GO:0038048dynorphin receptor activity IMP7624359
         
    Find genes that share ontologies with OPRK1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oprk1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  integument  reproductive system 

    Find genes that share phenotypes with OPRK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for OPRK1: Oprk1tm1Kff Oprk1tm1Jep

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPRK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OPRK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPRK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPRK1

    miRNA
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    miRTarBase miRNAs that target OPRK1:
    hsa-mir-106b-5p (MIRT020420)

    Block miRNA regulation of human, mouse, rat OPRK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OPRK1 (see all 26):
    hsa-miR-623 hsa-miR-3200-5p hsa-miR-188-5p hsa-miR-509-5p hsa-miR-885-5p hsa-miR-181a-2* hsa-miR-520a-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidOPRK1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OPRK1
    Predesigned siRNA for gene silencing in human, mouse, rat OPRK1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: OPRK1 (NM_000912)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRK1
    Addgene plasmids for OPRK1 

    Cell Line
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    GenScript OPRK1-overexpressing Cell Line for Assay
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPRK_HUMAN, P41145: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP7624359
    GO:0016021integral component of membrane IDA--

    Find genes that share ontologies with OPRK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPRK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression0.44


    Find genes that share SuperPaths with OPRK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for OPRK1
        DREAM Repression and Dynorphin Expression

    2 BioSystems Pathways for OPRK1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for OPRK1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for OPRK1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRK1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OPRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OPRK1 (P411451, 2, 3 ENSP000002655724) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-58245 I2D: score=3 STRING: ENSP00000262613
    GABARAPL1Q9H0R81, 3, ENSP000002664584EBI-925028,EBI-3464833 I2D: score=3 STRING: ENSP00000266458
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    OPRD1P411433, ENSP000002349614I2D: score=1 STRING: ENSP00000234961
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IDA8755601
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS7624359
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ISS--
    GO:0007268synaptic transmission TAS7624359

    Find genes that share ontologies with OPRK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for OPRK1
      Browse compounds at ApexBio 

    Compounds for OPRK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (-)-U-50488 hydrochlorideStandard selective kappa agonist. More active enantiomer of (+-)-U-50488 (Cat. No. 0495)[67198-19-0]
    nor-Binaltorphimine dihydrochlorideStandard kappa selective antagonist[105618-26-6]
    (+-)-U-50488 hydrochlorideStandard selective kappa agonist[67198-13-4]
    Dynorphin AEndogenous kappa agonist[80448-90-4]
    ICI 199,441 hydrochloride Potent kappa agonist[115199-84-3]

    2 HMDB Compounds for OPRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Codeine(-)-Codeine (see all 9)76-57-3--

    Selected DrugBank Compounds for OPRK1 (see all 32)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ButorphanolButorfanol (see all 4)58786-99-5targetagonist7705457 12127012 12470863 10779697 2555580 10381785 17909753 8746803 15942128 8968334
    Nalbuphine-- 20594-83-6targetagonist15655510 16517095 15602503 17139284 17407276 10534607 17016423 8388112 19403853
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2targetagonist7959748 17139284 16753266 9808678 17016423
    Naltrexone-- 16590-41-3targetantagonist18354714 9040115 11752352 19484223 17661275
    CodeineCodeine anhydrous (see all 6)76-57-3targetpartial agonist7885194 17139284 17016423 17620111
    DezocineDezocina [INN-Spanish] (see all 2)53648-55-8targetantagonist16433932 17139284 11752352 17016423
    3-Methylfentanyl3-MF (see all 3)42045-86-3targetagonist8576134 6264594 8030414
    Dihydromorphine-- 509-60-4targetagonist15178355 19474215 16777416
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist16433932 17720886 7739347
    HydromorphoneDihydromorfinon [Czech] (see all 7)466-99-9targetagonist16433932 17139284 17016423

    Selected IUPHAR Ligands for OPRK1 (kappa receptor) (see all 47)    About this table
    LigandTypeActionAffinityPubmed IDs
    nor-binaltorphimine
    AntagonistAntagonist8.9 - 112444704 7869844 9686407 7624359 9262330
    dynorphin A
    AgonistFull agonist8.3 - 10.87869844 9686407 7624359 9262330
    dynorphin A-(1-13)
    AgonistFull agonist9.3 - 10.79686407
    (-)-bremazocine
    AgonistPartial agonist10.59686407
    buprenorphine
    AntagonistAntagonist9.1 - 10.29686407 9262330
    alpha-neoendorphin
    AgonistFull agonist8.3 - 10.27624359 7869844
    TRK820
    AgonistFull agonist10.115383632
    (-)-EKC
    AgonistFull agonist109686407
    (-)-cyclazocine
    AgonistPartial agonist109686407
    dynorphin A-(1-8)
    AgonistFull agonist8 - 9.91967312 9686407 7624359

    Selected Novoseek inferred chemical compound relationships for OPRK1 gene (see all 116)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    norbinaltorphimine 93.7 95 7851478 (3), 12915238 (2), 7541509 (2), 10448921 (2) (see all 58)
    salvinorin a 92.2 67 14718611 (5), 17951511 (5), 19555087 (4), 12628350 (4) (see all 25)
    u69593 89.2 14 2176574 (2), 10669040 (2), 10448921 (2), 10440101 (1) (see all 6)
    enadoline 87.6 8 10448921 (2), 1316755 (1), 8867523 (1), 8627579 (1) (see all 6)
    u50488 86.9 25 9744578 (2), 12626643 (2), 10665828 (2), 12473373 (2) (see all 15)
    bremazocine 86.4 13 9833011 (3), 12915238 (2), 16007240 (2), 10448921 (2) (see all 8)
    [3h]diprenorphine 85.4 9 11076532 (2), 8387137 (1), 16006595 (1), 16505160 (1) (see all 6)
    cyclorphan 85.3 2 17433695 (1), 17276685 (1)
    morphinan 84.3 4 19634902 (1), 15542743 (1), 16076937 (1)
    tifluadom 83.7 1 11579457 (1)



    Find genes that share compounds with OPRK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OPRK1 gene (2 alternative transcripts): 
    NM_000912.3  NM_001282904.1  

    Unigene Cluster for OPRK1:

    Opioid receptor, kappa 1
    Hs.106795  [show with all ESTs]
    Unigene Representative Sequence: NM_000912
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265572(uc022aup.1 uc003xrh.1 uc003xri.1 uc010lyc.1)
    ENST00000522508 ENST00000524278 ENST00000520287
    miRNA
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    hsa-miR-623 hsa-miR-3200-5p hsa-miR-188-5p hsa-miR-509-5p hsa-miR-885-5p hsa-miR-181a-2* hsa-miR-520a-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidOPRK1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat OPRK1

    Additional mRNA sequence: 

    AF498922.1 AK023198.1 AK310233.1 AK310407.1 AK313058.1 AY168006.1 AY466378.1 BC099912.1 
    EF057067.1 L36130.1 L37362.1 U11053.1 U17298.1 

    4 DOTS entries:

    DT.100016314  DT.108243  DT.121472989  DT.101962844 

    15 AceView cDNA sequences:

    U17298 NM_000912 BX092912 L36130 CB565888 AY466378 L37362 AF498922 
    CF593603 U11053 AY168006 R81583 R81332 R31984 R31938 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OPRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATTCAGG
    OPRK1 Expression
    About this image


    OPRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Brain (Nervous System)
             Cerebellum
    OPRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106795

    UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145
    Tissue specificity: Detected in brain and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRK1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPRK1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oprk11 , 5 opioid receptor, kappa 11, 5 86.67(n)1
    93.68(a)1
      1 (1.89 cM)5
    183871  NM_001204371.11  NP_001191300.11 
     55884935 
    chicken
    (Gallus gallus)
    Aves OPRK11 opioid receptor, kappa 1 77.02(n)
    85.79(a)
      428533  XM_426087.3  XP_426087.2 
    lizard
    (Anolis carolinensis)
    Reptilia OPRK16
    opioid receptor, kappa 1
    79(a)
    1 ↔ 1
    GL343244.1(1368090-1392525)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oprk11 opioid receptor, kappa 1 68.82(n)
    79.3(a)
      100489465  XM_002934113.2  XP_002934159.2 
    zebrafish
    (Danio rerio)
    Actinopterygii oprk12 opioid receptor, kappa 1 79.65(n)   360139  AF285173.1 


    ENSEMBL Gene Tree for OPRK1 (if available)
    TreeFam Gene Tree for OPRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPRK1 gene
    SSTR32  OPRL12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for OPRK1 using alignment to 2 protein entries:     OPRK_HUMAN (see all proteins) (see all similar genes):
    OPRM1    OPRD1    OPRL1    NPBWR2    SSTR4    SSTR1
    CCR-5    SSTR2    CCR3    NPBWR1    SSTR3    SSTR5
    CCR5    CCR1    CXCR1    GALR1    GALR2    GPR24

    Find genes that share paralogs with OPRK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPRK1 (see all 897)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434571051,2
    Cuntested154147372(+) ATGACA/GACAGC 2 S L mis10--------
    rs1998595641,2
    C--54137780(+) TTTGTA/GTGTAA 1 -- ds50010--------
    rs736796841,2
    C,F--54137793(+) TACTAT/CGCGGT 1 -- ds50013Minor allele frequency- C:0.06WA CSA 122
    rs1450122591,2
    --54137795(+) CTATGA/CGGTTT 1 -- ds50010--------
    rs736796851,2
    C--54137796(+) TATGCG/AGTTTA 1 -- ds50012Minor allele frequency- A:0.06WA 120
    rs1491543661,2
    --54137961(+) GATTTC/TCATTG 1 -- ds50010--------
    rs1870976181,2
    --54137969(+) TTGTGA/GGAGCA 1 -- ds50010--------
    rs1432917511,2
    --54138190(+) CCTTAC/TAGTTT 1 -- ds50010--------
    rs736796861,2
    C,F--54138218(+) TGTTCT/CTGCTG 1 -- ds50013Minor allele frequency- C:0.06WA CSA 122
    rs169188351,2
    C,F--54138232(+) TGCAGC/TATCAC 1 -- ds500111Minor allele frequency- T:0.22NA WA CSA EA 510

    HapMap Linkage Disequilibrium report for OPRK1 (54138276 - 54164257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OPRK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6194CNV Insertion18451855
    nsv6193CNV Insertion18451855
    nsv397858CNV Insertion16902084
    nsv438054CNV Loss16468122
    esv260063OTHER Complex20981092

    Human Gene Mutation Database (HGMD): OPRK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for OPRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165196    OMIM disorders: --

    7 diseases for OPRK1:    
    About MalaCards
    uremic pruritus    morphine dependence    drug dependence    cocaine dependence
    cocaine abuse    hypertrophic scars    agoraphobia

    3 diseases from the University of Copenhagen DISEASES database for OPRK1:
    Agoraphobia     Pain agnosia     Alcohol dependence

    Find genes that share disorders with OPRK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for OPRK1 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    opioid dependence 54.2 3 9365966 (1), 9517399 (1)
    respiratory depression 48.4 1 19833235 (1)
    cocaine abuse 38 1 19253970 (1)
    cocaine dependence 32.5 1 15988468 (1)
    drug dependence 27.4 3 15542743 (2)
    morphine dependence 24.1 1 8544279 (1)
    brain diseases 20.5 6 9030693 (2), 9874464 (1), 12473373 (1), 7746504 (1) (see all 5)
    drug addiction 16.1 1 9729284 (1)
    hyperalgesia 8.73 1 15037816 (1)
    glioma 7.2 8 10646507 (3), 9918595 (2), 9874464 (1), 19828880 (1)

    Genetic Association Database (GAD): OPRK1
    Human Genome Epidemiology (HuGE) Navigator: OPRK1 (20 documents)

    Export disorders for OPRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPRK1 gene, integrated from 10 sources (see all 579):
    (articles sorted by number of sources associating them with OPRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. (PubMed id 17373729)1, 4, 9 Gerra G....Donnini C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    2. Association of the kappa-opioid system with alcohol dependence. (PubMed id 16924269)1, 4, 9 Xuei X....Edenberg H.J. (Mol. Psychiatry 2006)
    3. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (PubMed id 15608558)1, 4, 9 Yuferov V....Kreek M.J. (Pharmacogenetics 2004)
    4. A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. (PubMed id 18319328)1, 4, 9 Edenberg H.J....Foroud T. (Hum. Mol. Genet. 2008)
    5. Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. (PubMed id 18537939)1, 4, 9 Arias A.J....Kranzler H.R. (Alcohol. Clin. Exp. Res. 2008)
    6. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. (PubMed id 17374034)1, 4, 9 Gelernter J....Krystal J.H. (Alcohol. Clin. Exp. Res. 2007)
    7. Structure of the human kappa-opioid receptor in complex with JDTic. (PubMed id 22437504)1, 2 Wu H.... Stevens R.C. (Nature 2012)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4986 HGNC: 8154 AceView: OPRK1 Ensembl:ENSG00000082556 euGenes: HUgn4986
    ECgene: OPRK1 Kegg: 4986 H-InvDB: OPRK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OPRK1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Kappa_opioid_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPRK1 gene:
    Search GeneIP for patents involving OPRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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