Aliases for OPRD1 Gene
External Ids for OPRD1 Gene
Previous GeneCards Identifiers for OPRD1 Gene
GeneCards Summary for OPRD1 Gene
OPRD1 (Opioid Receptor, Delta 1) is a Protein Coding gene. Diseases associated with OPRD1 include morphine dependence and drug dependence. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include enkephalin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for OPRD1 Gene
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).