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Aliases for OPRD1 Gene

Aliases for OPRD1 Gene

  • Opioid Receptor, Delta 1 2 3
  • D-OR-1 3 4
  • DOR-1 3 4
  • OPRD 3 4
  • Delta-Type Opioid Receptor 3
  • Delta Opioid Receptor 1 3

External Ids for OPRD1 Gene

Summaries for OPRD1 Gene

GeneCards Summary for OPRD1 Gene

OPRD1 (Opioid Receptor, Delta 1) is a Protein Coding gene. Diseases associated with OPRD1 include morphine dependence and myocardial stunning. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include enkephalin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRD1 Gene

  • G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Tocris Summary for OPRD1 Gene

  • The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).

Gene Wiki entry for OPRD1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRD1 Gene

Genomics for OPRD1 Gene

Genomic Location for OPRD1 Gene

Start:
28,812,142 bp from pter
End:
28,863,696 bp from pter
Size:
51,555 bases
Orientation:
Plus strand

Genomic View for OPRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRD1 Gene

Regulatory Elements for OPRD1 Gene

Proteins for OPRD1 Gene

  • Protein details for OPRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41143-OPRD_HUMAN
    Recommended name:
    Delta-type opioid receptor
    Protein Accession:
    P41143
    Secondary Accessions:
    • B5B0B8

    Protein attributes for OPRD1 Gene

    Size:
    372 amino acids
    Molecular mass:
    40369 Da
    Quaternary structure:
    • May form homooligomers. Interacts with GPRASP1.

    Three dimensional structures from OCA and Proteopedia for OPRD1 Gene

neXtProt entry for OPRD1 Gene

Proteomics data for OPRD1 Gene at MOPED

Post-translational modifications for OPRD1 Gene

Other Protein References for OPRD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OPRD1 Gene

Domains for OPRD1 Gene

Gene Families for OPRD1 Gene

HGNC:
  • OPR :GPCR / Class A : Opioid receptors
IUPHAR :

UniProtKB/Swiss-Prot:

OPRD_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P41143
genes like me logo Genes that share domains with OPRD1: view

Function for OPRD1 Gene

Molecular function for OPRD1 Gene

GENATLAS Biochemistry: opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G protein-modulated K+ channel,regulating G protein expression in pineal gland
UniProtKB/Swiss-Prot Function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Gene Ontology (GO) - Molecular Function for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004985 opioid receptor activity IDA 22184124
GO:0005515 protein binding IPI 15086532
GO:0038046 enkephalin receptor activity IMP 9548483
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with OPRD1: view
genes like me logo Genes that share phenotypes with OPRD1: view

Animal Models for OPRD1 Gene

MGI Knock Outs for OPRD1:

miRNA for OPRD1 Gene

miRTarBase miRNAs that target OPRD1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OPRD1 Gene

Localization for OPRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRD1 Gene COMPARTMENTS Subcellular localization image for OPRD1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7808419
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OPRD1: view

Pathways for OPRD1 Gene

genes like me logo Genes that share pathways with OPRD1: view

Pathways by source for OPRD1 Gene

Gene Ontology (GO) - Biological Process for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 16325578
GO:0006955 immune response TAS 9548483
GO:0007186 G-protein coupled receptor signaling pathway IDA 16325578
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7808419
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with OPRD1: view

Compounds for OPRD1 Gene

(5) Tocris Compounds for OPRD1 Gene

Compound Action Cas Number
BW 373U86 Potent, selective non-peptide delta agonist [155836-52-5]
DPDPE Selective delta agonist [88373-73-3]
Naltrindole hydrochloride delta selective non-peptide antagonist [111469-81-9]
SDM25N hydrochloride Potent, selective non-peptide delta antagonist [342884-62-2]
SNC 80 Highly selective non-peptide delta agonist [156727-74-1]

(3) HMDB Compounds for OPRD1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Codeine
  • (-)-Codeine
76-57-3
Loperamide
  • Apo-Loperamide
53179-11-6

(31) Drugbank Compounds for OPRD1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Methylfentanyl
  • 3-MF
42045-86-3 target agonist
3-Methylthiofentanyl
86052-04-2 target agonist
Alvimopan
170098-38-1 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target agonist
Buprenorphine
  • Buprenophine
52485-79-7 target antagonist

(45) IUPHAR Ligand for OPRD1 Gene

Ligand Type Action Affinity Pubmed IDs
nor-binaltorphimine Antagonist Antagonist 11
dynorphin A Agonist Full agonist 10.8
dynorphin A-(1-13) Agonist Full agonist 10.7
(-)-bremazocine Agonist Partial agonist 10.5
(-)-cyclazocine Agonist Partial agonist 10
(-)-EKC Agonist Full agonist 10
dynorphin A-(1-8) Agonist Full agonist 9.9
dynorphin B Agonist Partial agonist 9.9
diprenorphine Antagonist Antagonist 9.7
(-)-quadazocine Antagonist Antagonist 9.7
etorphine Agonist Full agonist 9.7
dynorphin-(1-11) Agonist Full agonist 9.7
beta-FNA Antagonist Antagonist 9.7
nalmefene Antagonist Antagonist 9.5
naltrexone Antagonist Antagonist 9.4
[D-Ala2]deltorphin I Agonist Agonist 9.35
[3H]diprenorphine Antagonist Antagonist 9.1
nalorphine Agonist Partial agonist 9.1
TIPPpsi Antagonist Inverse agonist 9
deltorphin II Agonist Full agonist 8.8
DADLE Agonist Full agonist 8.7
DSTBULET Agonist Full agonist 8.6
(-)-pentazocine Agonist Partial agonist 8.6
naloxone Antagonist Antagonist 8.6
CTAP Antagonist Antagonist 8.6
naltriben Antagonist Antagonist 8.4
BNTX Antagonist Antagonist 8.4
endomorphin-1 Agonist Full agonist 8.3
DSLET Agonist Full agonist 8.2
[Leu]enkephalin Agonist Partial agonist 8.1
naltrindole Antagonist Antagonist 8
beta-endorphin Agonist Partial agonist 7.9
normorphine Agonist Full agonist 7.8
morphine Agonist Partial agonist 7.3
SNC80 Agonist Full agonist 7.2
fentanyl Agonist Partial agonist 7.1
dihydromorphine Agonist Partial agonist 7.1
etonitazene Agonist Partial agonist 6.9
(-)-methadone Agonist Partial agonist 6.5
[D-Ala2]deltorphin II Agonist Full agonist 5.6
DPDPE Inhibitor Inhibition
[3H]deltorphin II None None
[3H]DPDPE None None
[3H]naltrindole Antagonist Antagonist
[3H]naltriben Antagonist Antagonist

(121) Novoseek inferred chemical compound relationships for OPRD1 Gene

Compound -log(P) Hits PubMed IDs
dpdpe 94.2 62
naltrindole 93 49
bw 373u86 91.7 5
deltorphin i 90.9 19
snc 80 90.2 14
genes like me logo Genes that share compounds with OPRD1: view

Transcripts for OPRD1 Gene

mRNA/cDNA for OPRD1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPRD1 Gene

Opioid receptor, delta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPRD1 Gene

No ASD Table

Relevant External Links for OPRD1 Gene

GeneLoc Exon Structure for
OPRD1
ECgene alternative splicing isoforms for
OPRD1

Expression for OPRD1 Gene

mRNA expression in normal human tissues for OPRD1 Gene

mRNA differential expression in normal tissues according to GTEx for OPRD1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.8), Brain - Cortex (8.6), and Brain - Anterior cingulate cortex (BA24) (7.8).

SOURCE GeneReport for Unigene cluster for OPRD1 Gene Hs.372

mRNA Expression by UniProt/SwissProt for OPRD1 Gene

P41143-OPRD_HUMAN
Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
genes like me logo Genes that share expressions with OPRD1: view

Orthologs for OPRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRD1 36
  • 99.19 (n)
  • 99.19 (a)
OPRD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPRD1 36
  • 92.65 (n)
  • 95.97 (a)
OPRD1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRD1 36
  • 93.98 (n)
  • 96.85 (a)
OPRD1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprd1 36
  • 89.16 (n)
  • 93.55 (a)
Oprd1 16
Oprd1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPRD1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprd1 36
  • 90.5 (n)
  • 93.55 (a)
chicken
(Gallus gallus)
Aves OPRD1 36
  • 79.08 (n)
  • 77.59 (a)
OPRD1 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRD1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprd1 36
  • 67.99 (n)
  • 75 (a)
zebrafish
(Danio rerio)
Actinopterygii oprd1 36
oprd1a 36
  • 66.85 (n)
  • 70.7 (a)
oprd1a 37
  • 69 (a)
OneToMany
oprd1b 37
  • 67 (a)
OneToMany
Species with no ortholog for OPRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRD1 Gene

ENSEMBL:
Gene Tree for OPRD1 (if available)
TreeFam:
Gene Tree for OPRD1 (if available)

Paralogs for OPRD1 Gene

Selected SIMAP similar genes for OPRD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OPRD1: view

Variants for OPRD1 Gene

Sequence variations from dbSNP and Humsavar for OPRD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs169446 -- 28,817,739(+) tcact(C/G)tgttg intron-variant
rs172172 -- 28,850,102(-) aagat(C/T)gagac intron-variant
rs188116 -- 28,830,182(+) tctta(C/T)aggcg intron-variant
rs188118 -- 28,850,005(-) atact(C/T)tggag intron-variant
rs189962 -- 28,850,024(-) cgggc(A/C)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRD1 Gene

Variant ID Type Subtype PubMed ID
dgv3n21 CNV Loss 19592680
nsv460928 CNV Loss 19166990
nsv519203 CNV Gain 19592680
nsv871326 CNV Loss 21882294
nsv525310 CNV Loss 19592680
esv2745841 CNV Deletion 23290073

Relevant External Links for OPRD1 Gene

HapMap Linkage Disequilibrium report
OPRD1
Human Gene Mutation Database (HGMD)
OPRD1

Disorders for OPRD1 Gene

(1) University of Copenhagen DISEASES for OPRD1 Gene

(25) Novoseek inferred disease relationships for OPRD1 Gene

Disease -log(P) Hits PubMed IDs
glioma 54.5 26
opioid dependence 41.1 3
dependence psychological 36.2 1
hyperalgesia 29.9 1
morphine dependence 22.9 1

Relevant External Links for OPRD1

Genetic Association Database (GAD)
OPRD1
Human Genome Epidemiology (HuGE) Navigator
OPRD1
genes like me logo Genes that share disorders with OPRD1: view

No data available for UniProtKB/Swiss-Prot for OPRD1 Gene

Publications for OPRD1 Gene

  1. Identification of a human delta opioid receptor: cloning and expression. (PMID: 8201839) Knapp R.J. … Yamamura H.I. (Life Sci. 1994) 3 4 23
  2. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. (PMID: 16741914) Kobayashi H. … Sora I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 49
  3. The opioid system in alcohol and drug dependence: family-based association study. (PMID: 17503481) Xuei X. … Edenberg H.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 49
  4. Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum. (PMID: 17550902) LeskelAo T.T. … PetAojAo-Repo U.E. (J. Biol. Chem. 2007) 3 23
  5. The endoplasmic reticulum Ca2+-pump SERCA2b interacts with G protein-coupled receptors and enhances their expression at the cell surface. (PMID: 17588601) Tuusa J.T. … PetAojAo-Repo U.E. (J. Mol. Biol. 2007) 3 23

Products for OPRD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate OPRD1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for OPRD1
    • Block miRNA regulation of OPRD1 using miScript Target Protectors

    Sources for OPRD1 Gene

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