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OPRD1 Gene

protein-coding   GIFtS: 66
GCID: GC01P029144

Opioid Receptor, Delta 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opioid Receptor, Delta 11 2
D-OR-12 3
DOR-12 3
OPRD2 3
Delta Opioid Receptor 12
Delta-Type Opioid Receptor2

External Ids:    HGNC: 81531   Entrez Gene: 49852   Ensembl: ENSG000001163297   OMIM: 1651955   UniProtKB: P411433   

Export aliases for OPRD1 gene to outside databases

Previous GC identifers: GC01P028304 GC01P028643 GC01P028826 GC01P028959 GC01P029011 GC01P027391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OPRD1 Gene:
OPRD1 (opioid receptor, delta 1) is a protein-coding gene. Diseases associated with OPRD1 include morphine dependence, and drug dependence. GO annotations related to this gene include enkephalin receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143
Function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of
other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding
proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling
leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion
currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated
analgesia. Plays a role in developing analgesic tolerance to morphine

summary for OPRD1 Gene:
The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of
G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid
receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex,
with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a
role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function
and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands.
The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).

Gene Wiki entry for OPRD1 (Delta Opioid receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPRD1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   Pax-5   E2F-2   E2F   E2F-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRD1 promoter sequence
   Search Chromatin IP Primers for OPRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p34.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p36.1-p34.3

OPRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P029144:  view genomic region     (about GC identifiers)

Start:
29,138,654 bp from pter      End:
29,190,208 bp from pter
Size:
51,555 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143 (See protein sequence)
Recommended Name: Delta-type opioid receptor  
Size: 372 amino acids; 40369 Da
Subunit: May form homooligomers. Interacts with GPRASP1
3 PDB 3D structures from and Proteopedia for OPRD1:
1OZC (3D)        2IQM (3D)        4N6H (3D)    
Secondary accessions: B5B0B8

Explore the universe of human proteins at neXtProt for OPRD1: NX_P41143

Explore proteomics data for OPRD1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn18, Asn33
  • Modification sites at PhosphoSitePlus

  • See OPRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000902.3  
    ENSEMBL proteins: 
     ENSP00000234961  
    Reactome Protein details: P41143

    OPRD1 Human Recombinant Protein Products:

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    Novus Biologicals OPRD1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    OPRD1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of OPRD1
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    GenScript OPRD1-overexpressing Cell Line for Assay
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPR: GPCR / Class A : Opioid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: delta receptor
    Opioid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001418 Opioid_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000321 Delta_opi_rcpt

    Graphical View of Domain Structure for InterPro Entry P41143

    ProtoNet protein and cluster: P41143

    2 Blocks protein domains:
    IPB000321 Delta opioid receptor signature
    IPB001418 Opioid receptor signature


    UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OPRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRD_HUMAN, P41143
    Function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of
    other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding
    proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling
    leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion
    currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated
    analgesia. Plays a role in developing analgesic tolerance to morphine

         Genatlas biochemistry entry for OPRD1:
    opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G
    protein-modulated K+ channel,regulating G protein expression in pineal gland

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004985opioid receptor activity IDA--
    GO:0005515protein binding IPI15086532
    GO:0038046enkephalin receptor activity IMP9548483
         
    OPRD1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Oprd1):
     behavior/neurological  homeostasis/metabolism  integument  nervous system  no phenotypic analysis 

    OPRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OPRD1: Oprd1tm1Kff Oprd1tm1Jep

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPRD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OPRD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPRD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPRD1

    miRNA
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    miRTarBase miRNAs that target OPRD1:
    hsa-mir-744-5p (MIRT037618)

    Block miRNA regulation of human, mouse, rat OPRD1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidOPRD1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: OPRD1 (NM_000911)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPRD1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPRD_HUMAN, P41143: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7808419
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    OPRD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPRD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OPRD1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for OPRD1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for OPRD1):
        Neuroactive ligand-receptor interaction


    OPRD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRD1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OPRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OPRD1 (P411431, 2, 3 ENSP000002349614) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2A2P166151, 2, 3EBI-2624456,EBI-358933 MINT-7889342 MINT-7889483 MINT-7889371 I2D: score=1 
    GPRASP1Q5JY771, 3, ENSP000003551464EBI-2624456,EBI-2514717 I2D: score=2 STRING: ENSP00000355146
    CANXP278241, 2, 3, ENSP000002474614EBI-2624456,EBI-355947 MINT-7889342 MINT-7889483 MINT-7889460 MINT-7889449 I2D: score=1 STRING: ENSP00000247461
    GNAO1P094713, ENSP000002624934I2D: score=3 STRING: ENSP00000262493
    ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA16325578
    GO:0006955immune response TAS9548483
    GO:0007186G-protein coupled receptor signaling pathway IDA16325578
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7808419
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--

    OPRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for OPRD1
      Browse compounds at ApexBio 

    Compounds for OPRD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SDM25N hydrochloride Potent, selective non-peptide delta antagonist [342884-62-2]
    SNC 80Highly selective non-peptide delta agonist[156727-74-1]
    DPDPESelective delta agonist[88373-73-3]
    Naltrindole hydrochloridedelta selective non-peptide antagonist[111469-81-9]
    BW 373U86 Potent, selective non-peptide delta agonist [155836-52-5]

    3 HMDB Compounds for OPRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Codeine(-)-Codeine (see all 9)76-57-3--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    Selected DrugBank Compounds for OPRD1 (see all 31)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ButorphanolButorfanol (see all 4)58786-99-5targetagonist7705457 12127012 12470863 11752352 17909753 8746803 15942128 8968334
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist1316589 10999950 1665782 12672796 12606694 11752352 7739347
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2targetagonist12015197 16530171 16650582 16678156 16539674 11752352 16534251
    NaloxoneEN 1530 Base (see all 7)465-65-6targetantagonist18354714 14646257 12749773 12657847 14708857 17367258 12650833
    3-Methylthiofentanyl-- 86052-04-2targetagonist15665994 16861092 16372825 15828941 15868528 19403616
    CodeineCodeine anhydrous (see all 6)76-57-3targetagonist7885194 8119316 2156065 11752352 16386786 12067475
    Diprenorphine-- 14357-78-9targetantagonist10319982 10413036 12672796 11526449 20641600 12909189
    FentanylFentanila [INN-Spanish] (see all 3)437-38-7targetagonist15665994 16861092 16372825 15828941 15868528 19403616
    HydromorphoneDihydromorfinon [Czech] (see all 7)466-99-9targetpartial agonist17658959 11752352 9301669 2849950 2478994 7511163
    Naltrexone-- 16590-41-3targetantagonist9040115 17487229 11752352 9673788 17661275 15788780

    Selected IUPHAR Ligands for OPRD1 (delta receptor) (see all 45)    About this table
    LigandTypeActionAffinityPubmed IDs
    naltriben
    AntagonistAntagonist109686407 1851833
    naltrindole
    AntagonistAntagonist9.72832195 9686407
    [D-Ala2]deltorphin I
    AgonistAgonist9.353071223 1329092
    DSLET
    AgonistFull agonist9.39686407
    [3H]diprenorphine
    AgonistFull agonist9.39686407
    diprenorphine
    AgonistFull agonist9.39686407
    DADLE
    AgonistFull agonist9.29686407
    (-)-cyclazocine
    AgonistPartial agonist9.19686407
    TIPPpsi
    AntagonistInverse agonist99686407
    (-)-bremazocine
    AgonistFull agonist99686407

    Selected Novoseek inferred chemical compound relationships for OPRD1 gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpdpe 94.2 74 9822547 (3), 7925596 (2), 10650167 (2), 10231722 (2) (see all 53)
    naltrindole 93 58 1425962 (2), 12185408 (2), 8938656 (2), 8741185 (2) (see all 42)
    bw 373u86 91.7 6 8246161 (2), 11324539 (1), 8876019 (1), 9655881 (1)
    deltorphin i 90.9 23 8381356 (3), 1656944 (3), 1329092 (2), 19787815 (2) (see all 13)
    snc 80 90.2 14 10650167 (2), 12505529 (2), 9655881 (2), 11786497 (1) (see all 11)
    deltorphin 90 40 8157070 (4), 10893226 (3), 1369601 (3), 1656944 (3) (see all 15)
    deltorphin ii 88 5 14999000 (3), 17373766 (1), 15632119 (1)
    damgo 87.5 26 10789829 (2), 11834622 (2), 7925596 (1), 8001688 (1) (see all 20)
    naltriben 87.4 4 10516632 (1), 11665839 (1)
    oxymorphindole 86 1 2172675 (1)



    OPRD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OPRD1 gene: 
    NM_000911.3  

    Unigene Cluster for OPRD1:

    Opioid receptor, delta 1
    Hs.372  [show with all ESTs]
    Unigene Representative Sequence: NM_000911
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000234961(uc001brf.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: OPRD1 (NM_000911)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OPRD1
      QuantiTect SYBR Green Assays in human, mouse, rat OPRD1
      QuantiFast Probe-based Assays in human, mouse, rat OPRD1

    Additional mRNA sequence: 

    EF057065.1 EU883570.1 U07882.2 U10504.1 

    1 DOTS entry:

    DT.106072 

    4 AceView cDNA sequences:

    U10504 BF434068 U07882 NM_000911 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OPRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGGCCT
    OPRD1 Expression
    About this image

    OPRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372

    UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143
    Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus
    and olfactory bulb. Detected in oocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPRD1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPRD1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oprd11 , 5 opioid receptor, delta 11, 5 89.16(n)1
    93.55(a)1
      4 (64.78 cM)5
    183861  NM_013622.31  NP_038650.31 
     1321107265 
    chicken
    (Gallus gallus)
    Aves OPRD11 opioid receptor, delta 1 79.08(n)
    77.59(a)
      429951  XM_427506.4  XP_427506.3 
    lizard
    (Anolis carolinensis)
    Reptilia OPRD16
    opioid receptor, delta 1
    73(a)
    1 ↔ 1
    GL343904.1(101550-119830)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oprd11 opioid receptor, delta 1 67.99(n)
    75(a)
      100490669  XM_002939358.2  XP_002939404.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oprd12 opioid receptor, delta 1 76.38(n)   30509  AJ001596.1 


    ENSEMBL Gene Tree for OPRD1 (if available)
    TreeFam Gene Tree for OPRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPRD1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for OPRD1 using alignment to 1 protein entry:     OPRD_HUMAN(see all similar genes):
    OPRM1    OPRL1    OPRK1    NPBWR1    NPBWR2    SSTR4
    SSTR1    SSTR2    SSTR5    SSTR3    GALR1    CCR1
    GPR24    MCHR2    AGTR2    CXCR1    MCHR1    CCR8

    OPRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPRD1 (see all 1122)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5693561,2
    C,F,A,H--29136686(-) AAGTAT/CTGtgt 1 -- us2k1 tfbs312Minor allele frequency- C:0.07NS EA NA CSA 681
    rs1917377621,2
    --29136743(+) ATACAC/TGGGAA 1 -- us2k10--------
    rs1130800871,2
    F--29136786(+) CTACTG/ACATAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1816644891,2
    --29136911(+) CCAGCC/TTTCCG 1 -- us2k10--------
    rs1432441881,2
    --29137028(+) CCCAAG/TTTCTC 1 -- us2k10--------
    rs1467356751,2
    --29137058(+) TTTCTC/GAGTAC 1 -- us2k10--------
    rs1855511881,2
    --29137185(+) TGGTAA/GAAGTG 1 -- us2k10--------
    rs1138982401,2
    C,F--29137187(+) GTAGAA/GGTGGC 1 -- us2k13Minor allele frequency- G:0.04NA WA 240
    rs764999981,2
    F--29137237(+) GGTGAG/CCTTGG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1112613151,2
    C--29137280(+) TAGGAG/ACCTTG 1 -- us2k12Minor allele frequency- A:0.08NA WA 120

    HapMap Linkage Disequilibrium report for OPRD1 (29138654 - 29190208 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OPRD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745841CNV Deletion23290073
    nsv460928CNV Loss19166990
    dgv3n21CNV Loss19592680
    nsv525310CNV Loss19592680
    nsv871326CNV Loss21882294
    nsv519203CNV Gain19592680

    Human Gene Mutation Database (HGMD): OPRD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for OPRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165195    OMIM disorders: --

    Selected diseases for OPRD1 (see all 43):    About MalaCards
    morphine dependence    drug dependence    myocardial stunning    drug addiction
    autosomal recessive nonsyndromic deafness    substance dependence    heroin dependence    chronic pain
    nonsyndromic deafness    diabetic neuropathy    hiv/aids    cholera
    anorexia nervosa    hypoglycemia    prion disease    autoimmune hepatitis
    alcohol dependence    cholestasis    differentiating neuroblastoma    pertussis

    1 disease from the University of Copenhagen DISEASES database for OPRD1:
    Alcohol dependence

    OPRD1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for OPRD1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 54.5 27 1322307 (2), 1331640 (2), 8866697 (2), 1847209 (2) (see all 22)
    opioid dependence 41.1 3 17503481 (2), 20300121 (1)
    dependence psychological 36.2 1 11316510 (1)
    hyperalgesia 29.9 1 2010815 (1)
    morphine dependence 22.9 1 10414444 (1)
    drug addiction 21.9 1 19128202 (1)
    cholera 18.6 1 1317000 (1)
    respiratory depression 14.6 2 12937621 (1), 19151246 (1)
    drug dependence 9.97 1 17503481 (1)
    alcoholism 7 2 17503481 (2)

    Genetic Association Database (GAD): OPRD1
    Human Genome Epidemiology (HuGE) Navigator: OPRD1 (26 documents)

    Export disorders for OPRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPRD1 gene, integrated from 10 sources (see all 611):
    (articles sorted by number of sources associating them with OPRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. (PubMed id 16741914)1, 4, 9 Kobayashi H....Sora I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    2. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. (PubMed id 19032295)1, 4, 9 Huang C.J....Tsai P.S. (Anaesthesia 2008)
    3. The opioid system in alcohol and drug dependence: family-based association study. (PubMed id 17503481)1, 4, 9 Xuei X....Edenberg H.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    4. Identification of a human delta opioid receptor: cloning and expression. (PubMed id 8201839)1, 2, 9 Knapp R.J.... Yamamura H.I. (Life Sci. 1994)
    5. Modulation of postendocytic sorting of G protein-coupled receptors. (PubMed id 12142540)1, 2, 9 Whistler J.L.... Von Zastrow M. (Science 2002)
    6. Cys-27 variant of human I'-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. (PubMed id 22184124)1, 2 LeskelAo T.T....PetAojAo-Repo U.E. (J. Biol. Chem. 2012)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4985 HGNC: 8153 AceView: OPRD1 Ensembl:ENSG00000116329 euGenes: HUgn4985
    ECgene: OPRD1 Kegg: 4985 H-InvDB: OPRD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OPRD1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Delta_opioid_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPRD1 gene:
    Search GeneIP for patents involving OPRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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