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Aliases for OPRD1 Gene

Aliases for OPRD1 Gene

  • Opioid Receptor Delta 1 2 3
  • Opioid Receptor, Delta 1 2 3 5
  • D-OR-1 3 4
  • DOR-1 3 4
  • OPRD 3 4
  • Delta Opioid Receptor 1 3

External Ids for OPRD1 Gene

Previous GeneCards Identifiers for OPRD1 Gene

  • GC01P029144
  • GC01P028304
  • GC01P028643
  • GC01P028959
  • GC01P029011
  • GC01P027391

Summaries for OPRD1 Gene

GeneCards Summary for OPRD1 Gene

OPRD1 (Opioid Receptor Delta 1) is a Protein Coding gene. Diseases associated with OPRD1 include morphine dependence and heroin dependence. Among its related pathways are cGMP-PKG signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and opioid receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for OPRD1 Gene

  • G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Tocris Summary for OPRD1 Gene

  • The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens and neocortex.

Gene Wiki entry for OPRD1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRD1 Gene

Genomics for OPRD1 Gene

Regulatory Elements for OPRD1 Gene

Enhancers for OPRD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPRD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPRD1 Gene

Chromosome:
1
Start:
28,812,142 bp from pter
End:
28,871,267 bp from pter
Size:
59,126 bases
Orientation:
Plus strand

Genomic View for OPRD1 Gene

Genes around OPRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRD1 Gene

Proteins for OPRD1 Gene

  • Protein details for OPRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41143-OPRD_HUMAN
    Recommended name:
    Delta-type opioid receptor
    Protein Accession:
    P41143
    Secondary Accessions:
    • B5B0B8

    Protein attributes for OPRD1 Gene

    Size:
    372 amino acids
    Molecular mass:
    40369 Da
    Quaternary structure:
    • May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for OPRD1 Gene

neXtProt entry for OPRD1 Gene

Proteomics data for OPRD1 Gene at MOPED

Post-translational modifications for OPRD1 Gene

  • N-glycosylated.
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
  • Glycosylation at Asn 18 and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for OPRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OPRD1 Gene

Domains & Families for OPRD1 Gene

Gene Families for OPRD1 Gene

Suggested Antigen Peptide Sequences for OPRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41143

UniProtKB/Swiss-Prot:

OPRD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRD1: view

Function for OPRD1 Gene

Molecular function for OPRD1 Gene

GENATLAS Biochemistry:
opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G protein-modulated K+ channel,regulating G protein expression in pineal gland
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
genes like me logo Genes that share phenotypes with OPRD1: view

Animal Models for OPRD1 Gene

MGI Knock Outs for OPRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for OPRD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRD1 Gene

Localization for OPRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPRD1 Gene COMPARTMENTS Subcellular localization image for OPRD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043679 axon terminus IEA --
genes like me logo Genes that share ontologies with OPRD1: view

Pathways & Interactions for OPRD1 Gene

genes like me logo Genes that share pathways with OPRD1: view

Gene Ontology (GO) - Biological Process for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IBA --
GO:0008344 adult locomotory behavior IEA --
GO:0019233 sensory perception of pain IBA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 24613828
GO:0038003 opioid receptor signaling pathway IEA,IMP 9548483
genes like me logo Genes that share ontologies with OPRD1: view

No data available for SIGNOR curated interactions for OPRD1 Gene

Drugs & Compounds for OPRD1 Gene

(145) Drugs for OPRD1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naltrexone Approved, Investigational Pharma Antagonist, antagonist, Target 367
Morphine Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 889
Naloxone Approved Pharma Antagonist, antagonist, Target 233
Fentanyl Approved, Illicit, Investigational Pharma Full agonist, Agonist, agonist, Target 721
Buprenorphine Approved, Illicit, Investigational Pharma Antagonist, agonist, Target, antagonist 381

(63) Additional Compounds for OPRD1 Gene - From: Novoseek, Tocris, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Snc 80
156727-74-1
(-)-EKC
Full agonist, Agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]naltrindole
Antagonist
beta-FNA
Antagonist

(5) Tocris Compounds for OPRD1 Gene

Compound Action Cas Number
[D-Ala2]-Deltorphin II Selective delta agonist peptide 122752-16-3
DPDPE Selective delta agonist 88373-73-3
FIT Irreversible delta agonist 85951-63-9
SB 205607 dihydrobromide Selective, high affinity non-peptide delta1 agonist 1217628-73-3
SNC 80 Highly selective non-peptide delta agonist 156727-74-1

(8) ApexBio Compounds for OPRD1 Gene

Compound Action Cas Number
ADL5859 HCl δ-opioid receptor agonist,selective 850173-95-4
Beta-Lipotropin (1-10), porcine Morphine-like substance 77875-68-4
Endomorphin-1 Agonist of μopioid receptors,highly potent and selective 189388-22-5
Loperamide HCl 34552-83-5
Meptazinol HCl 59263-76-2
Naloxone HCl 357-08-4
Naltrexone HCl 16676-29-2
Trimebutine Antimuscarinic 39133-31-8
genes like me logo Genes that share compounds with OPRD1: view

Drug Products

Transcripts for OPRD1 Gene

mRNA/cDNA for OPRD1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPRD1 Gene

Opioid receptor, delta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPRD1 Gene

No ASD Table

Relevant External Links for OPRD1 Gene

GeneLoc Exon Structure for
OPRD1
ECgene alternative splicing isoforms for
OPRD1

Expression for OPRD1 Gene

mRNA expression in normal human tissues for OPRD1 Gene

mRNA differential expression in normal tissues according to GTEx for OPRD1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.8), Brain - Cortex (x8.6), and Brain - Anterior cingulate cortex (BA24) (x7.8).

SOURCE GeneReport for Unigene cluster for OPRD1 Gene Hs.372

mRNA Expression by UniProt/SwissProt for OPRD1 Gene

P41143-OPRD_HUMAN
Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
genes like me logo Genes that share expression patterns with OPRD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OPRD1 Gene

Orthologs for OPRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OPRD1 35
  • 92.65 (n)
  • 95.97 (a)
OPRD1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPRD1 35
  • 93.98 (n)
  • 96.85 (a)
OPRD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oprd1 35
  • 89.16 (n)
  • 93.55 (a)
Oprd1 16
Oprd1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OPRD1 35
  • 99.19 (n)
  • 99.19 (a)
OPRD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprd1 35
  • 90.5 (n)
  • 93.55 (a)
oppossum
(Monodelphis domestica)
Mammalia OPRD1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRD1 35
  • 79.08 (n)
  • 77.59 (a)
OPRD1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRD1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprd1 35
  • 67.99 (n)
  • 75 (a)
zebrafish
(Danio rerio)
Actinopterygii oprd1 35
oprd1a 35
  • 66.85 (n)
  • 70.7 (a)
oprd1a 36
  • 69 (a)
OneToMany
oprd1b 36
  • 67 (a)
OneToMany
Species with no ortholog for OPRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRD1 Gene

ENSEMBL:
Gene Tree for OPRD1 (if available)
TreeFam:
Gene Tree for OPRD1 (if available)

Paralogs for OPRD1 Gene

(24) SIMAP similar genes for OPRD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OPRD1: view

Variants for OPRD1 Gene

Sequence variations from dbSNP and Humsavar for OPRD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1042114 - 28,812,463(+) CGCCT(G/T)CCCCA reference, missense
rs169446 -- 28,817,739(+) tcact(C/G)tgttg intron-variant
rs172172 -- 28,850,102(-) aagat(C/T)gagac intron-variant
rs188116 -- 28,830,182(+) tctta(C/T)aggcg intron-variant
rs188118 -- 28,850,005(-) atact(C/T)tggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPRD1 Gene

Variant ID Type Subtype PubMed ID
dgv3n21 CNV Loss 19592680
nsv460928 CNV Loss 19166990
nsv519203 CNV Gain 19592680
nsv871326 CNV Loss 21882294
nsv525310 CNV Loss 19592680
esv2745841 CNV Deletion 23290073

Variation tolerance for OPRD1 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPRD1 Gene

HapMap Linkage Disequilibrium report
OPRD1
Human Gene Mutation Database (HGMD)
OPRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRD1 Gene

Disorders for OPRD1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for OPRD1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
morphine dependence
heroin dependence
neonatal abstinence syndrome
  • drug withdrawal syndrome in newborn
drug dependence
  • substance dependence
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search OPRD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OPRD1

Genetic Association Database (GAD)
OPRD1
Human Genome Epidemiology (HuGE) Navigator
OPRD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OPRD1
genes like me logo Genes that share disorders with OPRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRD1 Gene

Publications for OPRD1 Gene

  1. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. (PMID: 16741914) Kobayashi H. … Sora I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48 67
  2. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. (PMID: 17487229) Weerts E.M. … McCaul M.E. (Neuropsychopharmacology 2008) 23 25 26
  3. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. (PMID: 14600248) Thompson C.M. … Selley D.E. (J. Pharmacol. Exp. Ther. 2004) 23 25 26
  4. Opioid reward mechanisms: a key role in drug abuse? (PMID: 9673788) Herz A. (Can. J. Physiol. Pharmacol. 1998) 23 25 26
  5. Discriminative stimulus effects of butorphanol: influence of training dose on the substitution patterns produced by Mu, Kappa and Delta opioid agonists. (PMID: 8968334) Picker M.J. … Smith M.A. (J. Pharmacol. Exp. Ther. 1996) 23 25 26

Products for OPRD1 Gene

Sources for OPRD1 Gene

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