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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPRD1 Gene

protein-coding   GIFtS: 65
GCID: GC01P029144

opioid receptor, delta 1

 Explore 44 diseases affiliated with
OPRD1 via our new
 Human Malady Compendium 
Biological research products
for OPRD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Opioid Receptor, Delta 11 2
D-OR-12 3
DOR-12 3
OPRD2 3
Delta Opioid Receptor 12
Delta-Type Opioid Receptor2

External Ids:    HGNC: 81531   Entrez Gene: 49852   Ensembl: ENSG000001163297   OMIM: 1651955   UniProtKB: P411433   

Export aliases for OPRD1 gene to outside databases

Previous GC identifers: GC01P028304 GC01P028643 GC01P028826 GC01P028959 GC01P029011 GC01P027391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143
Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
Highly stereoselective. receptor for enkephalins

summary for OPRD1:
The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of
G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid
receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex,
with low-moderate levels present in the thalamus, hypothalamus and brainstem. Delta opioid receptors play a
role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function
and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands.
The human gene encoding the delta opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).

Gene Wiki entry for OPRD1 (Delta Opioid receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPRD1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   Pax-5   E2F-2   E2F   E2F-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OPRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p34.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p36.1-p34.3

OPRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPRD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P029144:  view genomic region     (about GC identifiers)

Start:
29,138,654 bp from pter      End:
29,190,208 bp from pter
Size:
51,555 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143 (See protein sequence)
Recommended Name: Delta-type opioid receptor  
Size: 372 amino acids; 40369 Da
Subunit: Interacts with GPRASP1
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for OPRD1:
1OZC (3D)        2IQM (3D)    
Secondary accessions: B5B0B8

Explore the universe of human proteins at neXtProt for OPRD1: NX_P41143

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41143

  • OPRD1 Protein expression data from MOPED and PaxDb:    About this image 
    OPRD1 Protein Expression
    REFSEQ proteins: NP_000902.3  
    ENSEMBL proteins: 
     ENSP00000234961  
    Reactome Protein details: P41143
    Human Recombinant Protein Products for OPRD1: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7808419
    GO:0016021integral to membrane ----

    OPRD1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OPRD1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001418 Opioid_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000321 Delta_opi_rcpt

    Graphical View of Domain Structure for InterPro Entry P41143

    ProtoNet protein and cluster: P41143

    2 Blocks protein families:
    IPB000321 Delta opioid receptor signature
    IPB001418 Opioid receptor signature


    UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPRD_HUMAN, P41143
    Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
    Highly stereoselective. receptor for enkephalins

         Genatlas biochemistry entry for OPRD1:
    opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G protein-modulated K+
    channel,regulating G protein expression in pineal gland

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004985opioid receptor activity ----
    GO:0004986delta-opioid receptor activity ----
    GO:0005515protein binding IPI15086532
    GO:0038046enkephalin receptor activity IMP9548483
         
    OPRD1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Oprd1):
     behavior/neurological  homeostasis/metabolism  integument  nervous system  no phenotypic analysis 

    OPRD1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for OPRD1: Oprd1tm1Kff Oprd1tm1Jep
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OPRD1 

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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    G alpha (i) signalling events0.44
    GPCR ligand binding0.75
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.61
    Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    Peptide GPCRs0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for OPRD1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for OPRD1 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for OPRD1 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for OPRD1):
        Neuroactive ligand-receptor interaction


    OPRD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for OPRD1 (P411431, 2, 3 ENSP000002349614) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2A2P166152, 3MINT-7889342 MINT-7889483 MINT-7889371 I2D: score=1 
    GPRASP1Q5JY771, 3, ENSP000003551464EBI-2624456,EBI-2514717 I2D: score=2 STRING: ENSP00000355146
    CANXP278242, 3, ENSP000002474614MINT-7889342 MINT-7889483 MINT-7889460 MINT-7889449 I2D: score=1 STRING: ENSP00000247461
    GNAO1P094713, ENSP000002624934I2D: score=3 STRING: ENSP00000262493
    ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA16325578
    GO:0006955immune response TAS9548483
    GO:0007186G-protein coupled receptor signaling pathway IDA16325578
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7808419
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--

    OPRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OPRD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for OPRD1

    Compounds for OPRD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SNC 162 Potent, selective non-peptide delta agonist [178803-51-5]
    Deltorphin IPotent delta agonist[122752-15-2]
    SB 205607 dihydrobromide delta1 selective, high affinity non-peptide agonist [148545-09-9]
    SNC 80Highly selective non-peptide delta agonist[156727-74-1]
    AR-M 1000390Low-internalizing delta opioid receptor agonist[209808-47-9]

    3 HMDB Compounds for OPRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Codeine(-)-Codeine (see all 9)76-57-3--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    10/30 DrugBank Compounds for OPRD1 (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ButorphanolButorfanol (see all 4)58786-99-5targetagonist7705457 12127012 12470863 11752352 17909753 8746803 15942128 8968334
    Etorphine19-Propylorvinol (see all 7)14521-96-1targetagonist1316589 10999950 1665782 12672796 12606694 11752352 7739347
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2targetagonist12015197 16530171 16650582 16678156 16539674 11752352 16534251
    NaloxoneEN 1530 Base (see all 7)465-65-6targetantagonist18354714 14646257 12749773 12657847 14708857 17367258 12650833
    3-Methylthiofentanyl-- 86052-04-2targetagonist15665994 16861092 16372825 15828941 15868528 19403616
    CodeineCodeine anhydrous (see all 6)76-57-3targetagonist7885194 8119316 2156065 11752352 16386786 12067475
    Diprenorphine-- 14357-78-9targetantagonist10319982 10413036 12672796 11526449 20641600 12909189
    FentanylFentanila [INN-Spanish] (see all 3)437-38-7targetagonist15665994 16861092 16372825 15828941 15868528 19403616
    HydromorphoneDihydromorfinon [Czech] (see all 7)466-99-9targetpartial agonist17658959 11752352 9301669 2849950 2478994 7511163
    Naltrexone-- 16590-41-3targetantagonist9040115 17487229 11752352 9673788 17661275 15788780

    10/121 Novoseek chemical compound relationships for OPRD1 gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpdpe 94.2 74 9822547 (3), 7925596 (2), 10650167 (2), 10231722 (2) (see all 53)
    naltrindole 93 58 1425962 (2), 12185408 (2), 8938656 (2), 8741185 (2) (see all 42)
    bw 373u86 91.7 6 8246161 (2), 11324539 (1), 8876019 (1), 9655881 (1)
    deltorphin i 90.9 23 8381356 (3), 1656944 (3), 1329092 (2), 19787815 (2) (see all 13)
    snc 80 90.2 14 10650167 (2), 12505529 (2), 9655881 (2), 11786497 (1) (see all 11)
    deltorphin 90 40 8157070 (4), 10893226 (3), 1369601 (3), 1656944 (3) (see all 15)
    deltorphin ii 88 5 14999000 (3), 17373766 (1), 15632119 (1)
    damgo 87.5 26 10789829 (2), 11834622 (2), 7925596 (1), 8001688 (1) (see all 20)
    naltriben 87.4 4 10516632 (1), 11665839 (1)
    oxymorphindole 86 1 2172675 (1)

    Search CenterWatch for drugs/clinical trials and news about OPRD1 / OPRD 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OPRD1 gene: 
    NM_000911.3  

    Unigene Cluster for OPRD1:

    Opioid receptor, delta 1
    Hs.372  [show with all ESTs]
    Unigene Representative Sequence: NM_000911
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000234961(uc001brf.1)

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    Additional cDNA sequence: 

    EF057065.1 EU883570.1 U07882.2 U10504.1 

    1 DOTS entry:

    DT.106072 

    4 AceView cDNA sequences:

    U10504 BF434068 NM_000911 U07882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTGGGCCT
    OPRD1 Expression
    About this image
    See OPRD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPRD1

    SOURCE GeneReport for Unigene cluster: Hs.372
        SABiosciences Expression via Pathway-Focused PCR Arrays including OPRD1: 

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              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OPRD1 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OPRD11 opioid receptor, delta 1 79.57(n)
    77.97(a)
      429951  XM_427506.3  XP_427506.2 
    lizard
    (Anolis carolinensis)
    Reptilia OPRD16
    --
    74(a)
    1 ↔ 1
    GL343904.1(101791-115396)
    zebrafish
    (Danio rerio)
    Actinopterygii oprd12 opioid receptor, delta 1 76.38(n)   30509  AJ001596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta star16
    AlCR26
    allatostatin C receptor 2
    22(a)
    20(a)
    many ↔ many
    many ↔ many
    3L(18553358-18569426)
    3L(18478237-18495657)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E2A.16
    --
    12(a)
    possible ortholog
    II(14734335-14739167)


    ENSEMBL Gene Tree for OPRD1 (if available)
    TreeFam Gene Tree for OPRD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPRD1 gene
    SSTR32  SSTR42  GALR22  MCHR22  SSTR12  GALR32  OPRL12  NPBWR12  
    OPRK12  KISS1R2  GALR12  SSTR52  SSTR22  MCHR12  NPBWR22  OPRM12  
    18/25 SIMAP similar genes for OPRD1 using alignment to 1 protein entry:     OPRD_HUMAN(see all similar genes):
    OPRM1    OPRK1    OPRL1    NPBWR1    NPBWR2    SSTR4
    SSTR1    SSTR2    SSTR5    SSTR3    GALR1    CCR1
    GPR24    MCHR2    AGTR2    CXCR1    MCHR1    CCR8

    OPRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/942 NCBI SNPs in OPRD1 are shown (see all 942    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5693561,2
    C,F,A,H--29136686(-) AAGTAT/CTGTGT 1 -- us2k1 tfbs312Minor allele frequency- C:0.07NS EA NA CSA 681
    rs1917377621,2
    --29136743(+) ATACAC/TGGGAA 1 -- us2k10--------
    rs1130800871,2
    --29136786(+) CTACTG/ACATAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1816644891,2
    --29136911(+) CCAGCC/TTTCCG 1 -- us2k10--------
    rs1432441881,2
    --29137028(+) CCCAAG/TTTCTC 1 -- us2k10--------
    rs1467356751,2
    --29137058(+) TTTCTC/GAGTAC 1 -- us2k10--------
    rs1855511881,2
    --29137185(+) TGGTAA/GAAGTG 1 -- us2k10--------
    rs1138982401,2
    C--29137187(+) GTAGAA/GGTGGC 1 -- us2k13Minor allele frequency- G:0.04NA WA 240
    rs764999981,2
    F--29137237(+) GGTGAG/CCTTGG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1112613151,2
    C--29137280(+) NNNNAG/ACCTTG 1 -- us2k12Minor allele frequency- A:0.08NA WA 120

    HapMap Linkage Disequilibrium report for OPRD1 (29138654 - 29190208 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OPRD1
         1 CNV: 48307
    Human Gene Mutation Database (HGMD): OPRD1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for OPRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OPRD1 for disorders           About GeneDecksing

    OMIM gene information: 165195    OMIM disorders: --

    20/44 diseases for OPRD1 (see all 44):    About MalaCards
    autosomal recessive nonsyndromic deafness    morphine dependence    drug dependence    drug addiction
    heroin dependence    autism spectrum disorder    myocardial stunning    nonsyndromic deafness
    substance dependence    anorexia nervosa    alcohol dependence    rheumatoid arthritis
    chronic pain    prion disease    hypoglycemia    cholestasis
    parkinson's disease    diabetic neuropathy    cystic fibrosis    cholera

    1 disease from the University of Copenhagen DISEASES database for OPRD1:
    Alcohol dependence

    10/25 Novoseek disease relationships for OPRD1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 54.5 27 1322307 (2), 1331640 (2), 8866697 (2), 1847209 (2) (see all 22)
    opioid dependence 41.1 3 17503481 (2), 20300121 (1)
    dependence psychological 36.2 1 11316510 (1)
    hyperalgesia 29.9 1 2010815 (1)
    morphine dependence 22.9 1 10414444 (1)
    drug addiction 21.9 1 19128202 (1)
    cholera 18.6 1 1317000 (1)
    respiratory depression 14.6 2 12937621 (1), 19151246 (1)
    drug dependence 9.97 1 17503481 (1)
    alcoholism 7 2 17503481 (2)

    Genetic Association Database (GAD): OPRD1
    Human Genome Epidemiology (HuGE) Navigator: OPRD1 (26 documents)

    Export disorders for OPRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPRD1 gene, integrated from 9 sources (see all 603):
    (articles sorted by number of sources associating them with OPRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human delta opioid receptor: cloning and expression. (PubMed id 8201839)1, 2, 9 Knapp R.J.... Yamamura H.I. (1994)
    2. Modulation of postendocytic sorting of G protein-coupled receptors. (PubMed id 12142540)1, 2, 9 Whistler J.L.... Von Zastrow M. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. (PubMed id 14745298)1, 4 Loh e.l. . . . . . . . . . . .W....Cheng A.T. (2004)
    5. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)1, 2 Simonin F....Kieffer B.L. (2004)
    6. Opioid receptor random mutagenesis reveals a mechanism for G protein- coupled receptor activation. (PubMed id 12847517)1, 2 Decaillot F.M....Kieffer B.L. (2003)
    7. Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. (PubMed id 12116270)1, 4 Xu K....Goldman D. (2002)
    8. Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. (PubMed id 10982041)1, 2 Gelernter J. and Kranzler H.R. (2000)
    9. The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. (PubMed id 7808419)1, 2 Simonin F.... Kieffer B. (1994)
    10. Regional expression and chromosomal localization of the delta opiate receptor gene. (PubMed id 8415697)1, 3 Bzdega T....Klee W.A. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4985 HGNC: 8153 AceView: OPRD1 Ensembl:ENSG00000116329 euGenes: HUgn4985
    ECgene: OPRD1 Kegg: 4985 H-InvDB: OPRD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPRD1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Delta_opioid_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OPRD1 gene:
    Search GeneIP for patents involving OPRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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