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Aliases for OPN5 Gene

Aliases for OPN5 Gene

  • Opsin 5 2 3 5
  • Transmembrane Protein 13 2 3 4
  • Neuropsin 2 3 4
  • G-Protein Coupled Receptor 136 3 4
  • TMEM13 3 4
  • GPR136 3 4
  • PGR12 3 4
  • G-Protein Coupled Receptor PGR12 4
  • GRP136 3

External Ids for OPN5 Gene

Previous HGNC Symbols for OPN5 Gene

  • TMEM13

Previous GeneCards Identifiers for OPN5 Gene

  • GC06P047796
  • GC06P047857
  • GC06P047477

Summaries for OPN5 Gene

Entrez Gene Summary for OPN5 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for OPN5 Gene

OPN5 (Opsin 5) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Opsins. GO annotations related to this gene include G-protein coupled receptor activity and 11-cis retinal binding. An important paralog of this gene is OPN1SW.

Gene Wiki entry for OPN5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN5 Gene

Genomics for OPN5 Gene

Regulatory Elements for OPN5 Gene

Enhancers for OPN5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPN5 Gene

47,780,302 bp from pter
47,857,840 bp from pter
77,539 bases
Plus strand

Genomic View for OPN5 Gene

Genes around OPN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN5 Gene

Proteins for OPN5 Gene

  • Protein details for OPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0AV33
    • Q5T5B9
    • Q5T886
    • Q7Z603
    • Q86SL5

    Protein attributes for OPN5 Gene

    354 amino acids
    Molecular mass:
    39727 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI20454.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OPN5 Gene

Proteomics data for OPN5 Gene at MOPED

Post-translational modifications for OPN5 Gene

Other Protein References for OPN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN5 Gene

Domains & Families for OPN5 Gene

Gene Families for OPN5 Gene

Protein Domains for OPN5 Gene

Suggested Antigen Peptide Sequences for OPN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN5: view

Function for OPN5 Gene

Gene Ontology (GO) - Molecular Function for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005502 11-cis retinal binding IEA --
genes like me logo Genes that share ontologies with OPN5: view
genes like me logo Genes that share phenotypes with OPN5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OPN5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPN5 Gene

Localization for OPN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OPN5 Gene COMPARTMENTS Subcellular localization image for OPN5 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for OPN5 Gene

Pathways & Interactions for OPN5 Gene

genes like me logo Genes that share pathways with OPN5: view

Interacting Proteins for OPN5 Gene

Gene Ontology (GO) - Biological Process for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0071482 cellular response to light stimulus IBA --
genes like me logo Genes that share ontologies with OPN5: view

No data available for SIGNOR curated interactions for OPN5 Gene

Drugs & Compounds for OPN5 Gene

No Compound Related Data Available

Transcripts for OPN5 Gene

mRNA/cDNA for OPN5 Gene

Unigene Clusters for OPN5 Gene

Opsin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPN5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP3: - - - -
SP5: -

Relevant External Links for OPN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPN5 Gene

mRNA expression in normal human tissues for OPN5 Gene

mRNA differential expression in normal tissues according to GTEx for OPN5 Gene

This gene is overexpressed in Testis (x39.8) and Heart - Left Ventricle (x4.9).

SOURCE GeneReport for Unigene cluster for OPN5 Gene Hs.213717

mRNA Expression by UniProt/SwissProt for OPN5 Gene

Tissue specificity: Detected in brain and retina and cell lines derived from neural retina.
genes like me logo Genes that share expression patterns with OPN5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OPN5 Gene

Orthologs for OPN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPN5 35
  • 92.9 (n)
  • 96.02 (a)
OPN5 36
  • 90 (a)
(Canis familiaris)
Mammalia OPN5 35
  • 94.03 (n)
  • 97.16 (a)
OPN5 36
  • 97 (a)
(Mus musculus)
Mammalia Opn5 35
  • 89.96 (n)
  • 95.74 (a)
Opn5 16
Opn5 36
  • 89 (a)
(Pan troglodytes)
Mammalia OPN5 35
  • 99.81 (n)
  • 99.72 (a)
OPN5 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Opn5 35
  • 88.28 (n)
  • 93.9 (a)
(Monodelphis domestica)
Mammalia OPN5 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia OPN5 36
  • 83 (a)
(Gallus gallus)
Aves OPN5 35
  • 74.95 (n)
  • 78.32 (a)
OPN5 36
  • 76 (a)
(Anolis carolinensis)
Reptilia OPN5 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia opn5 35
  • 72.9 (n)
  • 75.67 (a)
(Danio rerio)
Actinopterygii opn5 35
  • 67.15 (n)
  • 67.53 (a)
opn5 36
  • 67 (a)
Species with no ortholog for OPN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN5 Gene

Gene Tree for OPN5 (if available)
Gene Tree for OPN5 (if available)

Paralogs for OPN5 Gene

Paralogs for OPN5 Gene

(3) SIMAP similar genes for OPN5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OPN5: view

Variants for OPN5 Gene

Sequence variations from dbSNP and Humsavar for OPN5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1159924 -- 47,786,213(-) CCCAG(A/G)GTGGA intron-variant, upstream-variant-2KB
rs1199011 -- 47,804,283(+) TGACC(C/T)AAAAA intron-variant
rs1199016 -- 47,845,363(+) tcatt(C/T)cttct intron-variant
rs1199017 -- 47,845,492(+) ACTGT(A/T)TTTAG intron-variant
rs1199018 -- 47,849,661(+) TGAAA(A/C)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPN5 Gene

Variant ID Type Subtype PubMed ID
esv269317 CNV Insertion 20981092

Variation tolerance for OPN5 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OPN5 Gene

Disorders for OPN5 Gene

Relevant External Links for OPN5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OPN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPN5 Gene

Publications for OPN5 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 67
  2. Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. (PMID: 14623103) Tarttelin E.E. … Lucas R.J. (FEBS Lett. 2003) 2 3
  3. Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. (PMID: 24403072) Yamashita T. … Shichida Y. (J. Biol. Chem. 2014) 3
  4. [Neuropsin signaling as a novel therapeutic target of schizophrenia]. (PMID: 24614639) Tawara-Hirata Y. (Nippon Yakurigaku Zasshi 2014) 3
  5. Light-induced rapid CaA^a8_ response and MAPK phosphorylation in the cells heterologously expressing human OPN5. (PMID: 24941910) Sugiyama T. … Takahashi T. (Sci Rep 2014) 3

Products for OPN5 Gene

Sources for OPN5 Gene