OPN5 Gene
protein-coding GIFtS: 50
GCID: GC06P047749
|
|
opsin 5(Previous name: transmembrane protein 13 )
(Previous symbol: TMEM13)
| |
Aliases
for OPN5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Opsin 51 2 | | G-Protein Coupled Receptor 1362 3 | | Transmembrane Protein 131 2 3 | | DJ402H5.11 | | TMEM131 2 3 | | Opsin-51 | | Neuropsin3 | | Neuropsin3 | | GPR1362 3 | | G-Protein Coupled Receptor PGR123 | | PGR122 3 | | |
Export aliases for OPN5 gene to outside databasesPrevious GC identifers: GC06P047796 GC06P047857 GC06P047477 |
Summaries
for OPN5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OPN5:
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin geneis expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalianopsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exonopsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Jun 2010)
Gene Wiki entry for OPN5
|
Genomic Views
for OPN5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OPN5 gene promoter:
AhR STAT5B ISGF-3 POU2F1 STAT5A Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for OPN5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.3 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12.3OPN5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P047749: view genomic region
(about GC identifiers)
Start:
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47,749,718 bp from pter |
End:
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47,800,516 bp from pter |
Size:
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50,799 bases |
Orientation:
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plus strand |
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Proteins
for OPN5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OPN5_HUMAN, Q6U736 (See
protein sequence)Recommended Name: Opsin-5 Size: 354 amino acids; 39727 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAI20454.1; Type=Erroneous gene model prediction;
Secondary accessions: A0AV33 Q5T5B9 Q5T886 Q7Z603 Q86SL5Explore the universe of human proteins at neXtProt for OPN5: NX_Q6U736
Post-translational modifications:
It is uncertain whether Cys-315 or Cys-316 is palmitoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6U736
OPN5 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_859528.1
ENSEMBL proteins: ENSP00000426991 ENSP00000360255 ENSP00000377302 Reactome Protein details: Q6U736
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
OPN5 for ontologies About GeneDecksing
OPN5 Antibody Products:
Assay Products for OPN5: |
Protein
Domains /
Families
for OPN5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OPN5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6U736ProtoNet protein and cluster: Q6U736 1 Blocks protein family: IPB001760 Opsin
UniProtKB/Swiss-Prot: OPN5_HUMAN, Q6U736Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily |
Function
for OPN5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OPN5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPN5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0009881 | photoreceptor activity |
IEA | -- |
OPN5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for OPN5:
|
Pathways & Interactions
for OPN5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Opsins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for OPN5 (see all 7)
OPN5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OPN5
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
OPN5 for ontologies About GeneDecksing
|
Drugs & Compounds
for OPN5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OPN5
Search CenterWatch for drugs/clinical trials and news about OPN5
|
Transcripts
for OPN5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OPN5 gene (2 alternative transcripts): NM_181744.3 NM_001030051.1 Unigene Cluster for OPN5: Opsin 5 Hs.213717 [show with all ESTs]Unigene Representative Sequence: NR_0338065 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489301 ENST00000371211 ENST00000393699 ENST00000244799(uc003ozc.3 uc003ozd.3)
ENST00000510695
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OPN5 (NM_181744) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPN5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPN5 |
Additional cDNA sequence: AY255615.1 AY288419.1 AY377391.1 BC042544.1 BC126194.1 BC126198.1 BX647224.1 NR_033806.1 3 DOTS entries: DT.75191000 DT.101977807 DT.99930927 10 AceView cDNA sequences: NM_181744 BX647224 AY288419 AY377391 AY255615 AA232919 BC042544 AI810121 BG721121 AI910964
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for OPN5 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OPN5
|
Expression
for OPN5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OPN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGACACTCA
About this image
Genevestigator expression for OPN5
SOURCE GeneReport for Unigene cluster: Hs.213717
UniProtKB/Swiss-Prot: OPN5_HUMAN, Q6U736Tissue specificity: Detected in brain and retina and cell lines derived from neural retina
SABiosciences Expression via Pathway-Focused PCR Array including OPN5: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPN5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPN5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN5 |
Orthologs
for OPN5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OPN5 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for OPN5 (if available)
TreeFam Gene Tree for OPN5 (if available) |
Paralogs
for OPN5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OPN5 gene
- OPN32 OPN1MW2 OPN1SW2 RHO2 RGR2 OPN42 OPN1MW22 RRH2
- OPN1LW2
3 SIMAP similar genes for OPN5 using alignment to 3 protein entries: OPN5_HUMAN (see all proteins):RRH OPN3 OPN4
OPN5 for paralogs About GeneDecksing
|
Genomic Variants
for OPN5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OPN5 (47749718 - 47800516 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OPN5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPN5 |
|
Disorders
/ Diseases
for OPN5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OPN5 for disorders About GeneDecksing
OMIM gene information: 609042
OMIM disorders: --
2  diseases for OPN5: About MalaCardsretinitis bipolar disorder
Export disorders for OPN5 gene to outside databases
|
Publications
for OPN5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OPN5 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with OPN5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. (PubMed id 14623103)1, 2, 3 Tarttelin E.E.... Lucas R.J. (2003)
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2, 3 Fredriksson R....Schioeth H.B. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The G protein-coupled receptor repertoires of human and mouse. (PubMed id 12679517)1, 2 Vassilatis D.K.... Gaitanaris G.A. (2003)
- UV-sensitive photoreceptor protein OPN5 in humans and mice. (PubMed id 22043319)1 Kojima D....Fukada Y. (2011)
- Genetic Variations of Human Neuropsin Gene and Psychiatric Disorders: Polymorphism Screening and Possible Association with Bipolar Disorder and Cognitive Functions. (PubMed id 18354391)1 Izumi A....Kunugi H. (2008)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The opsins. (PubMed id 15774036)1 Terakita A. (2005)
|
External Searches for OPN5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OPN5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OPN5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OPN5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OPN5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OPN5 gene:
Search GeneIP for patents involving OPN5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OPN5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for OPN5 | | OriGene shRNA RFP for OPN5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPN5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPN5 | | | OriGene Protein Over-expression Lysate for OPN5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OPN5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPN5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OPN5 | | OriGene Custom Protein Services for OPN5 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OPN5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPN5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPN5 |
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| |  |  |  |  | | | | |
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 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN5 |
|  |  |  | | | | ThermoFisher Antibodies for OPN5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPN5 |
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