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Aliases for OPN5 Gene

Aliases for OPN5 Gene

  • Opsin 5 2 3
  • Transmembrane Protein 13 2 3 4
  • Neuropsin 2 3 4
  • G-Protein Coupled Receptor 136 3 4
  • TMEM13 3 4
  • GPR136 3 4
  • PGR12 3 4
  • G-Protein Coupled Receptor PGR12 4
  • GRP136 3

External Ids for OPN5 Gene

Previous HGNC Symbols for OPN5 Gene

  • TMEM13

Previous GeneCards Identifiers for OPN5 Gene

  • GC06P047796
  • GC06P047857
  • GC06P047477

Summaries for OPN5 Gene

Entrez Gene Summary for OPN5 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for OPN5 Gene

OPN5 (Opsin 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and 11-cis retinal binding. An important paralog of this gene is OPN1SW.

Gene Wiki entry for OPN5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN5 Gene

Genomics for OPN5 Gene

Regulatory Elements for OPN5 Gene

Genomic Location for OPN5 Gene

47,780,302 bp from pter
47,857,840 bp from pter
77,539 bases
Plus strand

Genomic View for OPN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN5 Gene

Proteins for OPN5 Gene

  • Protein details for OPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0AV33
    • Q5T5B9
    • Q5T886
    • Q7Z603
    • Q86SL5

    Protein attributes for OPN5 Gene

    354 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for OPN5 Gene

Proteomics data for OPN5 Gene at MOPED

Post-translational modifications for OPN5 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OPN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OPN5 Gene

Domains & Families for OPN5 Gene

Gene Families for OPN5 Gene

Protein Domains for OPN5 Gene


Suggested Antigen Peptide Sequences for OPN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OPN5: view

No data available for UniProtKB/Swiss-Prot for OPN5 Gene

Function for OPN5 Gene

Gene Ontology (GO) - Molecular Function for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005502 11-cis retinal binding IEA --
GO:0009881 photoreceptor activity IEA --
genes like me logo Genes that share ontologies with OPN5: view
genes like me logo Genes that share phenotypes with OPN5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OPN5 Gene

Localization for OPN5 Gene

Gene Ontology (GO) - Cellular Components for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPN5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for OPN5 Gene

Pathways & Interactions for OPN5 Gene

genes like me logo Genes that share pathways with OPN5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for OPN5 Gene

Gene Ontology (GO) - Biological Process for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007601 visual perception IEA --
GO:0007602 phototransduction IEA --
GO:0018298 protein-chromophore linkage IEA --
genes like me logo Genes that share ontologies with OPN5: view

No data available for SIGNOR curated interactions for OPN5 Gene

Drugs & Compounds for OPN5 Gene

No Compound Related Data Available

Transcripts for OPN5 Gene

mRNA/cDNA for OPN5 Gene

Unigene Clusters for OPN5 Gene

Opsin 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPN5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPN5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP3: - - - -
SP5: -

Relevant External Links for OPN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPN5 Gene

mRNA expression in normal human tissues for OPN5 Gene

mRNA differential expression in normal tissues according to GTEx for OPN5 Gene

This gene is overexpressed in Testis (x39.8) and Heart - Left Ventricle (x4.9).

SOURCE GeneReport for Unigene cluster for OPN5 Gene Hs.213717

genes like me logo Genes that share expression patterns with OPN5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OPN5 Gene

Orthologs for OPN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPN5 35
  • 92.9 (n)
  • 96.02 (a)
OPN5 36
  • 90 (a)
(Canis familiaris)
Mammalia OPN5 35
  • 94.03 (n)
  • 97.16 (a)
OPN5 36
  • 97 (a)
(Mus musculus)
Mammalia Opn5 35
  • 89.96 (n)
  • 95.74 (a)
Opn5 16
Opn5 36
  • 89 (a)
(Pan troglodytes)
Mammalia OPN5 35
  • 99.81 (n)
  • 99.72 (a)
OPN5 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Opn5 35
  • 88.28 (n)
  • 93.9 (a)
(Monodelphis domestica)
Mammalia OPN5 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia OPN5 36
  • 83 (a)
(Gallus gallus)
Aves OPN5 35
  • 74.95 (n)
  • 78.32 (a)
OPN5 36
  • 76 (a)
(Anolis carolinensis)
Reptilia OPN5 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia opn5 35
  • 72.9 (n)
  • 75.67 (a)
(Danio rerio)
Actinopterygii opn5 35
  • 67.15 (n)
  • 67.53 (a)
opn5 36
  • 67 (a)
Species with no ortholog for OPN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN5 Gene

Gene Tree for OPN5 (if available)
Gene Tree for OPN5 (if available)

Paralogs for OPN5 Gene

Paralogs for OPN5 Gene

(3) SIMAP similar genes for OPN5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OPN5: view

Variants for OPN5 Gene

Sequence variations from dbSNP and Humsavar for OPN5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs471528 -- 47,848,609(+) CAGTC(C/T)TGATA intron-variant
rs473606 -- 47,840,441(+) TGATG(C/T)GAGTG intron-variant
rs474725 -- 47,840,276(+) GAACC(A/G)ACTAT intron-variant
rs479685 -- 47,843,263(+) ctact(A/G)tcaca intron-variant
rs480914 -- 47,830,682(+) ATTCT(G/T)TGGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OPN5 Gene

Variant ID Type Subtype PubMed ID
esv269317 CNV Insertion 20981092

Variation tolerance for OPN5 Gene

Residual Variation Intolerance Score: 26.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPN5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPN5 Gene

Disorders for OPN5 Gene

Relevant External Links for OPN5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OPN5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPN5 Gene

Publications for OPN5 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 67
  2. Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. (PMID: 14623103) Tarttelin E.E. … Lucas R.J. (FEBS Lett. 2003) 2 67
  3. [Neuropsin signaling as a novel therapeutic target of schizophrenia]. (PMID: 24614639) Tawara-Hirata Y. (Nippon Yakurigaku Zasshi 2014) 67
  4. Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. (PMID: 24403072) Yamashita T. … Shichida Y. (J. Biol. Chem. 2014) 67
  5. UV-sensitive photoreceptor protein OPN5 in humans and mice. (PMID: 22043319) Kojima D. … Fukada Y. (PLoS ONE 2011) 67

Products for OPN5 Gene

Sources for OPN5 Gene

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