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Aliases for OPN5 Gene

Aliases for OPN5 Gene

  • Opsin 5 2 3
  • Transmembrane Protein 13 2 3 4
  • Neuropsin 2 3 4
  • PGR12 3 4 6
  • G-Protein Coupled Receptor 136 3 4
  • TMEM13 3 4
  • GRP136 3 6
  • GPR136 3 4
  • G-Protein Coupled Receptor PGR12 4
  • Opsin-5 3

External Ids for OPN5 Gene

Previous HGNC Symbols for OPN5 Gene

  • TMEM13

Previous GeneCards Identifiers for OPN5 Gene

  • GC06P047796
  • GC06P047857
  • GC06P047477

Summaries for OPN5 Gene

Entrez Gene Summary for OPN5 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for OPN5 Gene

OPN5 (Opsin 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and photoreceptor activity. An important paralog of this gene is OPN1SW.

Gene Wiki entry for OPN5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN5 Gene

Genomics for OPN5 Gene

Regulatory Elements for OPN5 Gene

Genomic Location for OPN5 Gene

Start:
47,781,982 bp from pter
End:
47,832,780 bp from pter
Size:
50,799 bases
Orientation:
Plus strand

Genomic View for OPN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN5 Gene

Proteins for OPN5 Gene

  • Protein details for OPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U736-OPN5_HUMAN
    Recommended name:
    Opsin-5
    Protein Accession:
    Q6U736
    Secondary Accessions:
    • A0AV33
    • Q5T5B9
    • Q5T886
    • Q7Z603
    • Q86SL5

    Protein attributes for OPN5 Gene

    Size:
    354 amino acids
    Molecular mass:
    39727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20454.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OPN5 Gene

Proteomics data for OPN5 Gene at MOPED

Post-translational modifications for OPN5 Gene

Other Protein References for OPN5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN5 Gene

Domains for OPN5 Gene

Gene Families for OPN5 Gene

HGNC:
  • OPN :GPCR / Class A : Opsin receptors
IUPHAR :

Protein Domains for OPN5 Gene

Suggested Antigen Peptide Sequences for OPN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6U736

UniProtKB/Swiss-Prot:

OPN5_HUMAN :
  • Q6U736
Family:
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN5: view

Function for OPN5 Gene

Gene Ontology (GO) - Molecular Function for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005502 11-cis retinal binding IEA --
GO:0009881 photoreceptor activity IEA --
genes like me logo Genes that share ontologies with OPN5: view

Phenotypes for OPN5 Gene

genes like me logo Genes that share phenotypes with OPN5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OPN5 Gene

Localization for OPN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPN5 Gene COMPARTMENTS Subcellular localization image for OPN5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPN5: view

Pathways for OPN5 Gene

genes like me logo Genes that share pathways with OPN5: view

Interacting Proteins for OPN5 Gene

Gene Ontology (GO) - Biological Process for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007601 visual perception IEA --
GO:0007602 phototransduction IEA --
GO:0018298 protein-chromophore linkage IEA --
genes like me logo Genes that share ontologies with OPN5: view

Transcripts for OPN5 Gene

mRNA/cDNA for OPN5 Gene

Unigene Clusters for OPN5 Gene

Opsin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPN5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: -

Relevant External Links for OPN5 Gene

GeneLoc Exon Structure for
OPN5
ECgene alternative splicing isoforms for
OPN5

Expression for OPN5 Gene

mRNA expression in normal human tissues for OPN5 Gene

mRNA differential expression in normal tissues according to GTEx for OPN5 Gene

This gene is overexpressed in Testis (39.8) and Heart - Left Ventricle (4.9).

SOURCE GeneReport for Unigene cluster for OPN5 Gene Hs.213717

mRNA Expression by UniProt/SwissProt for OPN5 Gene

Q6U736-OPN5_HUMAN
Tissue specificity: Detected in brain and retina and cell lines derived from neural retina.
genes like me logo Genes that share expressions with OPN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for OPN5 Gene

Orthologs for OPN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPN5 35
  • 99.81 (n)
  • 99.72 (a)
OPN5 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPN5 35
  • 92.9 (n)
  • 96.02 (a)
OPN5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPN5 35
  • 94.03 (n)
  • 97.16 (a)
OPN5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Opn5 35
  • 89.96 (n)
  • 95.74 (a)
Opn5 16
Opn5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPN5 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPN5 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Opn5 35
  • 88.28 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves OPN5 35
  • 74.95 (n)
  • 78.32 (a)
OPN5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPN5 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia opn5 35
  • 72.9 (n)
  • 75.67 (a)
zebrafish
(Danio rerio)
Actinopterygii opn5 35
  • 67.15 (n)
  • 67.53 (a)
opn5 36
  • 67 (a)
OneToOne
Species with no ortholog for OPN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN5 Gene

ENSEMBL:
Gene Tree for OPN5 (if available)
TreeFam:
Gene Tree for OPN5 (if available)

Paralogs for OPN5 Gene

Paralogs for OPN5 Gene

Selected SIMAP similar genes for OPN5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OPN5: view

Variants for OPN5 Gene

Sequence variations from dbSNP and Humsavar for OPN5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs500980 -- 47,826,593(+) tcact(A/G)tgtgt downstream-variant-500B
rs505293 -- 47,798,569(+) AATGA(C/T)ATCAC intron-variant
rs506816 -- 47,815,233(+) TGAAA(G/T)AATCA intron-variant
rs512235 -- 47,822,503(+) TCCCA(A/G/T)TTTTT intron-variant
rs522065 -- 47,818,652(+) TCTCT(C/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPN5 Gene

Variant ID Type Subtype PubMed ID
esv269317 CNV Insertion 20981092

Relevant External Links for OPN5 Gene

HapMap Linkage Disequilibrium report
OPN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPN5 Gene

Disorders for OPN5 Gene

Relevant External Links for OPN5

Genetic Association Database (GAD)
OPN5
genes like me logo Genes that share disorders with OPN5: view

No data available for UniProtKB/Swiss-Prot for OPN5 Gene

Publications for OPN5 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4
  2. Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. (PMID: 14623103) Tarttelin E.E. … Lucas R.J. (FEBS Lett. 2003) 2 3 4
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OPN5 Gene

Sources for OPN5 Gene

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