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Aliases for OPN4 Gene

Aliases for OPN4 Gene

  • Opsin 4 2 3
  • Melanopsin 2 3
  • Opsin-4 3 4
  • MOP 3 4
  • Opsin 4 (Melanopsin) 2

External Ids for OPN4 Gene

Previous GeneCards Identifiers for OPN4 Gene

  • GC10P087296
  • GC10P087636
  • GC10P088545
  • GC10P088078
  • GC10P088404
  • GC10P082268
  • GC10P088417
  • GC10P088423

Summaries for OPN4 Gene

Entrez Gene Summary for OPN4 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OPN4 Gene

OPN4 (Opsin 4) is a Protein Coding gene. Diseases associated with OPN4 include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled photoreceptor activity and 11-cis retinal binding. An important paralog of this gene is OPN1SW.

UniProtKB/Swiss-Prot for OPN4 Gene

  • Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).

Gene Wiki entry for OPN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN4 Gene

Genomics for OPN4 Gene

Regulatory Elements for OPN4 Gene

Genomic Location for OPN4 Gene

Start:
86,654,557 bp from pter
End:
86,666,848 bp from pter
Size:
12,292 bases
Orientation:
Plus strand

Genomic View for OPN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN4 Gene

Proteins for OPN4 Gene

  • Protein details for OPN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHM6-OPN4_HUMAN
    Recommended name:
    Melanopsin
    Protein Accession:
    Q9UHM6
    Secondary Accessions:
    • B7ZLB3
    • Q14D01
    • Q2PP22
    • Q8NGQ9

    Protein attributes for OPN4 Gene

    Size:
    478 amino acids
    Molecular mass:
    52635 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05951.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OPN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPN4 Gene

Proteomics data for OPN4 Gene at MOPED

Post-translational modifications for OPN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OPN4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN4 Gene

Domains for OPN4 Gene

Gene Families for OPN4 Gene

HGNC:
  • OPN :GPCR / Class A : Opsin receptors

Protein Domains for OPN4 Gene

Suggested Antigen Peptide Sequences for OPN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHM6

UniProtKB/Swiss-Prot:

OPN4_HUMAN :
  • Q9UHM6
Family:
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN4: view

Function for OPN4 Gene

Molecular function for OPN4 Gene

UniProtKB/Swiss-Prot Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).

Gene Ontology (GO) - Molecular Function for OPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005502 11-cis retinal binding IDA 15674244
GO:0008020 G-protein coupled photoreceptor activity IDA 15674244
GO:0009881 photoreceptor activity --
genes like me logo Genes that share ontologies with OPN4: view
genes like me logo Genes that share phenotypes with OPN4: view

Animal Models for OPN4 Gene

MGI Knock Outs for OPN4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OPN4 Gene

Localization for OPN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN4 Gene

Cell membrane; Multi-pass membrane protein. Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPN4 Gene COMPARTMENTS Subcellular localization image for OPN4 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for OPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane TAS 10632589
genes like me logo Genes that share ontologies with OPN4: view

Pathways for OPN4 Gene

genes like me logo Genes that share pathways with OPN4: view

Gene Ontology (GO) - Biological Process for OPN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007601 visual perception IEA --
GO:0007602 phototransduction IDA 15674244
GO:0016056 rhodopsin mediated signaling pathway IEA --
GO:0018298 protein-chromophore linkage IEA --
genes like me logo Genes that share ontologies with OPN4: view

Compounds for OPN4 Gene

(5) Novoseek inferred chemical compound relationships for OPN4 Gene

Compound -log(P) Hits PubMed IDs
melatonin 68.4 9
retinoid 30.5 1
adenylate 11.5 2
calcium 0 4
glutamate 0 1
genes like me logo Genes that share compounds with OPN4: view

Transcripts for OPN4 Gene

mRNA/cDNA for OPN4 Gene

(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPN4 Gene

Opsin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPN4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2: -
SP3:

Relevant External Links for OPN4 Gene

GeneLoc Exon Structure for
OPN4
ECgene alternative splicing isoforms for
OPN4

Expression for OPN4 Gene

mRNA expression in normal human tissues for OPN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPN4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (7.2), Brain - Nucleus accumbens (basal ganglia) (6.4), Muscle - Skeletal (4.7), Brain - Caudate (basal ganglia) (4.3), and Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OPN4 Gene

SOURCE GeneReport for Unigene cluster for OPN4 Gene Hs.283922

mRNA Expression by UniProt/SwissProt for OPN4 Gene

Q9UHM6-OPN4_HUMAN
Tissue specificity: Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.
genes like me logo Genes that share expressions with OPN4: view

Orthologs for OPN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPN4 35
  • 99.66 (n)
  • 99.8 (a)
OPN4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPN4 35
  • 85.63 (n)
  • 82.01 (a)
OPN4 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPN4 35
  • 84.84 (n)
  • 80.17 (a)
OPN4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Opn4 35
  • 82.83 (n)
  • 80.09 (a)
Opn4 16
Opn4 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPN4 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPN4 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Opn4 35
  • 81.53 (n)
  • 78.56 (a)
chicken
(Gallus gallus)
Aves OPN4 35
  • 65.68 (n)
  • 65.19 (a)
OPN4-2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPN4 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia opn4-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491785 35
  • 65.84 (n)
  • 68.41 (a)
zebrafish
(Danio rerio)
Actinopterygii opn4 35
opn4.1 36
  • 48 (a)
OneToMany
opn4a 36
  • 45 (a)
OneToMany
opn4b 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ninaE 35
  • 51.39 (n)
  • 40.13 (a)
ninaE 36
  • 30 (a)
ManyToMany
Rh2 36
  • 31 (a)
ManyToMany
Rh3 36
  • 27 (a)
ManyToMany
Rh4 36
  • 30 (a)
ManyToMany
Rh5 36
  • 27 (a)
ManyToMany
Rh6 36
  • 31 (a)
ManyToMany
Rh7 36
  • 25 (a)
ManyToMany
Rh3 37
  • 33 (a)
Rh6 37
  • 38 (a)
Rh2 37
  • 38 (a)
Rh5 37
  • 33 (a)
Rh4 37
  • 34 (a)
ninaE 37
  • 37 (a)
Rh7 37
  • 33 (a)
Species with no ortholog for OPN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN4 Gene

ENSEMBL:
Gene Tree for OPN4 (if available)
TreeFam:
Gene Tree for OPN4 (if available)

Paralogs for OPN4 Gene

Paralogs for OPN4 Gene

Selected SIMAP similar genes for OPN4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OPN4: view

Variants for OPN4 Gene

Sequence variations from dbSNP and Humsavar for OPN4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs909285 -- 86,659,662(+) CTTTT(C/T)GGCAT intron-variant
rs1079610 - 86,662,359(+) GCTGA(C/T)CAGCC reference, missense
rs1125774 -- 86,661,612(+) CCTGG(A/G)CAGTG intron-variant
rs2005943 -- 86,653,302(+) GTGAA(A/C)TCCTG upstream-variant-2KB
rs2007328 -- 86,652,952(+) TGCCC(A/G)GTCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OPN4 Gene

Variant ID Type Subtype PubMed ID
nsv467411 CNV Loss 19166990
nsv470968 CNV Loss 18288195
dgv116n27 CNV Loss 19166990
dgv791n71 CNV Gain 21882294
dgv792n71 CNV Gain 21882294
dgv793n71 CNV Gain 21882294
nsv524269 CNV Loss 19592680
nsv895836 CNV Loss 21882294
nsv895837 CNV Loss 21882294
nsv895839 CNV Gain 21882294
dgv794n71 CNV Loss 21882294
dgv795n71 CNV Loss 21882294
dgv796n71 CNV Loss 21882294

Relevant External Links for OPN4 Gene

HapMap Linkage Disequilibrium report
OPN4
Human Gene Mutation Database (HGMD)
OPN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPN4 Gene

Disorders for OPN4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OPN4 Gene including...

Search for OPN4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for OPN4 Gene

(2) Novoseek inferred disease relationships for OPN4 Gene

Disease -log(P) Hits PubMed IDs
retinal degeneration 61.2 3
retinitis pigmentosa 44.3 1

Relevant External Links for OPN4

Genetic Association Database (GAD)
OPN4
Human Genome Epidemiology (HuGE) Navigator
OPN4
genes like me logo Genes that share disorders with OPN4: view

No data available for UniProtKB/Swiss-Prot for OPN4 Gene

Publications for OPN4 Gene

  1. A novel human opsin in the inner retina. (PMID: 10632589) Provencio I. … Rollag M.D. (J. Neurosci. 2000) 2 3 4 23
  2. Addition of human melanopsin renders mammalian cells photoresponsive. (PMID: 15674244) Melyan Z. … Hankins M.W. (Nature 2005) 3 4 23
  3. A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (PMID: 18804284) Roecklein K.A. … Provencio I. (J Affect Disord 2009) 3 23 48
  4. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. (PMID: 15716953) Dacey D.M. … Gamlin P.D. (Nature 2005) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OPN4 Gene

Sources for OPN4 Gene

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