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OPN4 Gene

protein-coding   GIFtS: 58
GCID: GC10P088423

Opsin 4

(Previous name: opsin 4 (melanopsin))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opsin 41 2
melanopsin1 2
MOP2 3
Opsin 4 (Melanopsin)1
opsin-42
Opsin-43

External Ids:    HGNC: 144491   Entrez Gene: 942332   Ensembl: ENSG000001223757   OMIM: 6066655   UniProtKB: Q9UHM63   

Export aliases for OPN4 gene to outside databases

Previous GC identifers: GC10P087296 GC10P087636 GC10P088545 GC10P088078 GC10P088404 GC10P082268 GC10P088417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPN4 Gene:
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene
encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the
retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and
other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient
receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light
response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory
photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene
attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OPN4 Gene:
OPN4 (opsin 4) is a protein-coding gene. Diseases associated with OPN4 include poliomyelitis, and pandas. GO annotations related to this gene include 11-cis retinal binding and G-protein coupled photoreceptor activity. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: OPN4_HUMAN, Q9UHM6
Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other
non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis
retinal (By similarity)

Gene Wiki entry for OPN4 (Melanopsin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPN4 gene promoter:
         Spz1   RFX1   Pax-5   AML1a   STAT5A   AP-2gamma   YY1   RORalpha1   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPN4 promoter sequence
   Search Chromatin IP Primers for OPN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q22

OPN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088423:  view genomic region     (about GC identifiers)

Start:
88,414,314 bp from pter      End:
88,426,605 bp from pter
Size:
12,292 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OPN4_HUMAN, Q9UHM6 (See protein sequence)
Recommended Name: Melanopsin  
Size: 478 amino acids; 52635 Da
Sequence caution: Sequence=BAC05951.1; Type=Erroneous gene model prediction;
Secondary accessions: B7ZLB3 Q14D01 Q2PP22 Q8NGQ9
Alternative splicing: 2 isoforms:  Q9UHM6-1   Q9UHM6-2   

Explore the universe of human proteins at neXtProt for OPN4: NX_Q9UHM6

Explore proteomics data for OPN4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OPN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025186.1  NP_150598.1  

    ENSEMBL proteins: 
     ENSP00000241891   ENSP00000393132   ENSP00000361141  
    Reactome Protein details: Q9UHM6

    OPN4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR027430 Retinal_BS
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9UHM6

    ProtoNet protein and cluster: Q9UHM6

    1 Blocks protein domain: IPB001760 Opsin

    UniProtKB/Swiss-Prot: OPN4_HUMAN, Q9UHM6
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    OPN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPN4_HUMAN, Q9UHM6
    Function: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other
    non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis
    retinal (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:000550211-cis retinal binding IDA15674244
    GO:0008020G-protein coupled photoreceptor activity IDA15674244
    GO:0009881photoreceptor activity ----
         
    OPN4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Opn4):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  normal 
     vision/eye 

    OPN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Opn4tm1Skay for OPN4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPN4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OPN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPN4

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    4 qRT-PCR Assays for microRNAs that regulate OPN4:
    hsa-miR-3690 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidOPN4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OPN4

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPN4_HUMAN, Q9UHM6: Cell membrane; Multi-pass membrane protein (By similarity). Note=Found in soma, dendrites
    and proximal part of axons of certain retinal ganglion cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane TAS10632589

    OPN4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPN4 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Opsins
    Opsins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OPN4
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for OPN4
        G alpha (q) signalling events
    Opsins



    OPN4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPN4: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OPN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OPN4 (Q9UHM63 ENSP000003611414) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARR3P365753, ENSP000003115384I2D: score=1 STRING: ENSP00000311538
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007601visual perception IEA--
    GO:0007602phototransduction IDA15674244
    GO:0009584detection of visible light ----
    GO:0016056rhodopsin mediated signaling pathway IEA--

    OPN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OPN4

    5 Novoseek inferred chemical compound relationships for OPN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melatonin 68.4 12 16714268 (3), 17466865 (1), 15567166 (1), 19555449 (1) (see all 7)
    retinoid 30.5 1 15674243 (1)
    adenylate 11.5 2 15505076 (1), 18057331 (1)
    calcium 0 5 16961436 (3), 18422879 (1)
    glutamate 0 1 17652756 (1)



    OPN4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OPN4 gene (2 alternative transcripts): 
    NM_001030015.2  NM_033282.3  

    Unigene Cluster for OPN4:

    Opsin 4
    Hs.283922  [show with all ESTs]
    Unigene Representative Sequence: NM_001030015
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241891 ENST00000443292(uc009xsx.1) ENST00000372071(uc001kdp.3 uc001kdq.3 uc010qmk.1)

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate OPN4:
    hsa-miR-3690 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidOPN4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OPN4
      QuantiFast Probe-based Assays in human, mouse, rat OPN4

    Additional mRNA sequence: 

    AK310520.1 BC029291.1 BC113558.1 BC143688.1 DQ426884.1 

    3 DOTS entries:

    DT.102835934  DT.102835935  DT.121286529 

    10 AceView cDNA sequences:

    NM_033282 BM672338 BC029291 CD634974 BI819835 CD634973 CD634970 BM701008 
    CD634968 CD634967 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OPN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                                        -                                 
    SP2:                    -                                                                     
    SP3:                                                                                          


    ECgene alternative splicing isoforms for OPN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OPN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTCTCC
    OPN4 Expression
    About this image


    OPN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neurons
             Mature Ganglion Cells Ganglion Cell Layer
     
     Eye (Sensory Organs)
             Mature Ganglion Cells Ganglion Cell Layer
    OPN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283922

    UniProtKB/Swiss-Prot: OPN4_HUMAN, Q9UHM6
    Tissue specificity: Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OPN4: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for OPN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OPN4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OPN4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Opn41 , 5 opsin 4 (melanopsin)1, 5 82.83(n)1
    80.09(a)1
      14 (20.83 cM)5
    300441  NM_001128599.11  NP_001122071.11 
     345906185 
    chicken
    (Gallus gallus)
    Aves OPN41 opsin 4 65.68(n)
    65.19(a)
      423609  NM_001044653.1  NP_001038118.1 
    lizard
    (Anolis carolinensis)
    Reptilia OPN46
    opsin 4
    47(a)
    1 ↔ 1
    GL343368.1(1016503-1085661)
    African clawed frog
    (Xenopus laevis)
    Amphibia opn4-A2 opsin 4 (melanopsin) 70.84(n)    AF014797.1 
    zebrafish
    (Danio rerio)
    Actinopterygii opn42 opsin 4 (melanopsin) 73.96(n)   352918  AY078161.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rh63
    ninaE1
    phototransduction green-sensitive opsin3
    neither inactivation nor afterpotential E1
    38(a)
    (best of 7)3
    51.39(n)1
    40.13(a)1
      88F63
    423671  NM_079683.21  NP_524407.11 


    ENSEMBL Gene Tree for OPN4 (if available)
    TreeFam Gene Tree for OPN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPN4 gene
    OPN32  RGR2  OPN1MW22  OPN1LW2  OPN1MW2  OPN1SW2  RHO2  RRH2  
    OPN52  
    9 SIMAP similar genes for OPN4 using alignment to 2 protein entries:     OPN4_HUMAN (see all proteins):
    RHO    OPN1LW    CCR5    GPR50    OPN1MW    OPN1MW2
    RRH    OPN3    OPN5

    OPN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPN4 (see all 486)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437399601,2
    C,Funtested188415953(+) CCCACG/AGTTGA 4 /T syn11Minor allele frequency- A:0.00NA 4550
    rs1818061431,2
    --88412390(+) GCATTA/GAGCCT 2 -- us2k10--------
    rs1864549281,2
    --88412394(+) TGAGCA/CTAGGG 2 -- us2k10--------
    rs1912274161,2
    --88412644(+) TCCACA/TCCAGG 2 -- us2k10--------
    rs1128480231,2
    F--88412651(+) CAGGGC/TTCCAA 2 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1171267151,2
    C,F--88412702(+) TGACCG/ACTGCC 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs20073281,2
    F,H--88412709(+) TGCCCG/AGTCGG 2 -- us2k1 tfbs34Minor allele frequency- A:0.01NS EA 418
    rs115943631,2
    C,F,H--88412773(+) AAGCCG/ATGTGT 2 -- us2k112Minor allele frequency- A:0.22NS EA NA WA 868
    rs347160381,2
    C,F--88412783(+) TTCAGC/TTTCCC 2 -- us2k13Minor allele frequency- T:0.01NS NA 96
    rs70921511,2
    C,F,A,H--88412812(+) GCCTCC/TTCTAA 2 -- us2k1 tfbs37Minor allele frequency- T:0.10NS EA WA 628

    HapMap Linkage Disequilibrium report for OPN4 (88414314 - 88426605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OPN4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv796n71CNV Loss21882294
    dgv794n71CNV Loss21882294
    dgv795n71CNV Loss21882294
    nsv470968CNV Loss18288195
    nsv895837CNV Loss21882294
    nsv895836CNV Loss21882294
    dgv116n27CNV Loss19166990
    nsv467411CNV Loss19166990
    nsv524269CNV Loss19592680
    dgv791n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): OPN4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPN4
    DNA2.0 Custom Variant and Variant Library Synthesis for OPN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606665    OMIM disorders: --

    16 diseases for OPN4:    
    About MalaCards
    poliomyelitis    pandas    seasonal affective disorder    fundus dystrophy
    leber hereditary optic neuropathy    retinal degeneration    retinitis    diabetic retinopathy
    retinitis pigmentosa    glaucoma    neuropathy    blindness
    alzheimer's disease    malaria    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OPN4:
    Retinal degeneration

    OPN4 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for OPN4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 61.2 3 18442436 (1), 18836071 (1), 15505076 (1)
    retinitis pigmentosa 44.3 2 15509757 (1)

    Genetic Association Database (GAD): OPN4
    Human Genome Epidemiology (HuGE) Navigator: OPN4 (5 documents)

    Export disorders for OPN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPN4 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with OPN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human opsin in the inner retina. (PubMed id 10632589)1, 2, 3, 9 Provencio I....Rollag M.D. (J. Neurosci. 2000)
    2. A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (PubMed id 18804284)1, 4, 9 Roecklein K.A....Provencio I. (J Affect Disord 2009)
    3. Addition of human melanopsin renders mammalian cells photoresponsive. (PubMed id 15674244)1, 2, 9 Melyan Z.... Hankins M.W. (Nature 2005)
    4. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
    5. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (J Circadian Rhythms 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Melanopsin triggers the release of internal calcium stores in response to light. (PubMed id 16961436)1, 9 Kumbalasiri T....Provencio I. (Photochem. Photobiol. 2007)
    9. Induction of photosensitivity by heterologous expression of melanopsin. (PubMed id 15674243)1, 9 Qiu X....Berson D.M. (Nature 2005)
    10. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. (PubMed id 15716953)1, 9 Dacey D.M....Gamlin P.D. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94233 HGNC: 14449 AceView: OPN4 Ensembl:ENSG00000122375 euGenes: HUgn94233
    ECgene: OPN4 H-InvDB: OPN4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OPN4 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/opn4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPN4 gene:
    Search GeneIP for patents involving OPN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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