OPN4 Gene

Aliases
for OPN4 gene

Previous GC identifers: GC10P087296 GC10P087636 GC10P088545 GC10P088078 GC10P088404 GC10P082268

Summaries
for OPN4 gene

Genomic Views
for OPN4 gene

RefSeq DNA sequence:

NC_000010.10  NC_018921.1  NT_030059.13  

SwitchGear Promoter luciferase reporter plasmid: OPN4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN4

OPN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088417:  view genomic region     (about GC identifiers)

Proteins
for OPN4 gene

Explore the universe of human proteins at neXtProt for OPN4: NX_Q9UHM6

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: OPN4 OriGene Custom Protein Services for OPN4
	GenScript Custom Purified and Recombinant Proteins Services for OPN4
	Novus Biologicals OPN4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OPN4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for OPN4
	GenScript Custom Superior Antibodies Services for OPN4
	Novus Biologicals OPN4 Antibodies
	Search for Antibodies for OPN4 at Abcam
	Uscn Antibodies for OPN4
	ThermoFisher Antibodies for OPN4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OPN4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OPN4

Protein Domains /
Families
for OPN4 gene

ProtoNet protein and cluster: Q9UHM6

Function
for OPN4 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPN4
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate OPN4:
		hsa-miR-3690 hsa-miR-3150b-3p hsa-miR-3116 hsa-miR-542-3p
		SwitchGear 3'UTR luciferase reporter plasmid: OPN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPN4 (see all 7) OriGene shRNA RFP: OPN4 OriGene siRNA: OPN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPN4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for OPN4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPN4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPN4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): OPN4 (NM_033282)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPN4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPN4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OPN4
		Search LifeMap BioReagents cell lines for OPN4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 7 alleles) (MGI details for Opn4)

Pathways & Interactions
for OPN4 gene

	Super-pathway	contained gene-specific pathways
1	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 GPCRs, Class A Rhodopsin-like 0.41 GPCR ligand binding 0.75
2	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
3	G alpha (q) signalling events	G alpha (q) signalling events 1.00 Gastrin-CREB signalling pathway via PKC and MAPK 0.90
4	Opsins	Opsins 1.00

1 BioSystems Pathway for OPN4

GPCRs, Class A Rhodopsin-like

5/8        Reactome Pathways for OPN4

	GPCR downstream signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for OPN4 gene

Transcripts
for OPN4 gene

Expression
for OPN4 gene

OPN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTCTCC

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeGanglion Cell LayerMature Ganglion Cells			Ganglion, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPN4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPN4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN4

Orthologs
for OPN4 gene

Paralogs
for OPN4 gene

Paralogs for OPN4 gene

OPN3²  OPN1MW²  OPN1SW²  RHO²  RGR²  OPN1MW2²  RRH²  OPN1LW²  

OPN5²  

9 SIMAP similar genes for OPN4 using alignment to 2 protein entries:     OPN4_HUMAN (see all proteins):

RHO    OPN1LW    CCR5    GPR50    OPN1MW    OPN1MW2

RRH    OPN3    OPN5

OPN4 for paralogs           About GeneDecksing

Genomic Variants
for OPN4 gene

10/385 NCBI SNPs in OPN4 are shown (see all 385)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1437399601,2	C,F,	other	88415953(+)	CCCACG/AGTTGA	4	/T	syn1		1		NA	4550
rs1818061431,2		--	88412390(+)	GCATTA/GAGCCT	2	--	us2k1		0	--	--	--	--
rs1864549281,2		--	88412394(+)	TGAGCA/CTAGGG	2	--	us2k1		0	--	--	--	--
rs1912274161,2		--	88412644(+)	TCCACA/TCCAGG	2	--	us2k1		0	--	--	--	--
rs1128480231,2	F	--	88412651(+)	CAGGGC/TTCCAA	2	--	us2k1		2		CSA	4
rs1171267151,2	F,	--	88412702(+)	TGACCG/ACTGCC	2	--	us2k1		1		NA	120
rs20073281,2	F,H,	--	88412709(+)	TGCCCG/AGTCGG	2	--	us2k1 tfbs3		4		NS EA	418
rs115943631,2	C,F,H,	--	88412773(+)	AAGCCG/ATGTGT	2	--	us2k1		12		NS EA NA WA	868
rs347160381,2	C,	--	88412783(+)	TTCAGC/TTTCCC	2	--	us2k1		3		NS NA	96
rs70921511,2	C,F,A,H,	--	88412812(+)	GCCTCC/TTCTAA	2	--	us2k1 tfbs3		7		NS EA WA	628

HapMap Linkage Disequilibrium report for OPN4 (88414314 - 88426605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OPN4
     1 CNV: 53351
Human Gene Mutation Database (HGMD): OPN4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPN4

DNA2.0 Custom Variant and Variant Library Synthesis for OPN4

Disorders / Diseases
for OPN4 gene

14 diseases for OPN4

2 Novoseek disease relationships for OPN4 gene    About this table

Publications
for OPN4 gene

PubMed articles for OPN4 gene, integrated from 9 sources (see all 113): (articles sorted by number of sources associating them with OPN4)

Utopia: connect your pdf to the dynamic world of online information

1. A novel human opsin in the inner retina. (PubMed id 10632589)^{1, 2, 3, 9} Provencio I....Rollag M.D. (2000)
2. Addition of human melanopsin renders mammalian cells photoresponsive. (PubMed id 15674244)^{1, 2, 9} Melyan Z.... Hankins M.W. (2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Melanopsin triggers the release of internal calcium stores in response to light. (PubMed id 16961436)^{1, 9} Kumbalasiri T....Provencio I. (2007)
5. Induction of photosensitivity by heterologous expression of melanopsin. (PubMed id 15674243)^{1, 9} Qiu X....Berson D.M. (2005)
6. A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (PubMed id 18804284)^{1, 9} Roecklein K.A....Provencio I. (2008)
7. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. (PubMed id 15716953)^{1, 9} Dacey D.M....Gamlin P.D. (2005)
8. Biological rhythms in the context of light at night (LAN). (PubMed id 12163844)^{1, 9} Lerchl A. (2002)
9. Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans. (PubMed id 23055493)¹ Gooley J.J....Lockley S.W. (2012)
10. Melanopsin gene variations interact with season to pre dict sleep onset and chronotype. (PubMed id 22881342)¹ Roecklein K.A....Manuck S.B. (2012)

External Searches for OPN4 gene

Genome Databases showing OPN4 gene

Other Databases showing OPN4 gene

Specialized Databases showing OPN4 gene

Products
for OPN4 gene