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Aliases for OPN3 Gene

Aliases for OPN3 Gene

  • Opsin 3 2 3 5
  • Encephalopsin 2 3 4
  • Panopsin 2 4
  • ECPN 3 4
  • Protein Phosphatase 1, Regulatory Subunit 116 3
  • Opsin 3 (Encephalopsin, Panopsin) 3
  • Regulatory Subunit 116 2
  • Protein Phosphatase 1 2
  • PPP1R116 3

External Ids for OPN3 Gene

Previous HGNC Symbols for OPN3 Gene

  • ECPN

Previous GeneCards Identifiers for OPN3 Gene

  • GC01M239842
  • GC01M237209
  • GC01M238053
  • GC01M238797
  • GC01M238798
  • GC01M238082
  • GC01M241753
  • GC01M212214

Summaries for OPN3 Gene

Entrez Gene Summary for OPN3 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for OPN3 Gene

OPN3 (Opsin 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Opsins. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled photoreceptor activity. An important paralog of this gene is OPN1SW.

UniProtKB/Swiss-Prot for OPN3 Gene

  • May play a role in encephalic photoreception.

Gene Wiki entry for OPN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN3 Gene

Genomics for OPN3 Gene

Regulatory Elements for OPN3 Gene

Enhancers for OPN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPN3 Gene

241,590,102 bp from pter
241,677,376 bp from pter
87,275 bases
Minus strand

Genomic View for OPN3 Gene

Genes around OPN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN3 Gene

Proteins for OPN3 Gene

  • Protein details for OPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IX08
    • Q9Y344

    Protein attributes for OPN3 Gene

    402 amino acids
    Molecular mass:
    44873 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPN3 Gene


neXtProt entry for OPN3 Gene

Proteomics data for OPN3 Gene at MOPED

Post-translational modifications for OPN3 Gene

  • Glycosylation at Asn 5 and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for OPN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN3 Gene

Domains & Families for OPN3 Gene

Protein Domains for OPN3 Gene


Suggested Antigen Peptide Sequences for OPN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN3: view

Function for OPN3 Gene

Molecular function for OPN3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in encephalic photoreception.

Gene Ontology (GO) - Molecular Function for OPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008020 G-protein coupled photoreceptor activity NAS 10234000
genes like me logo Genes that share ontologies with OPN3: view
genes like me logo Genes that share phenotypes with OPN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OPN3

miRNA for OPN3 Gene

miRTarBase miRNAs that target OPN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPN3 Gene

Localization for OPN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OPN3 Gene COMPARTMENTS Subcellular localization image for OPN3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for OPN3 Gene

Pathways & Interactions for OPN3 Gene

genes like me logo Genes that share pathways with OPN3: view

Pathways by source for OPN3 Gene

Interacting Proteins for OPN3 Gene

Gene Ontology (GO) - Biological Process for OPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018298 protein-chromophore linkage IEA --
GO:0071482 cellular response to light stimulus IBA --
genes like me logo Genes that share ontologies with OPN3: view

No data available for SIGNOR curated interactions for OPN3 Gene

Drugs & Compounds for OPN3 Gene

(1) Drugs for OPN3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OPN3: view

Transcripts for OPN3 Gene

Unigene Clusters for OPN3 Gene

Opsin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPN3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP4: - - - - - -

Relevant External Links for OPN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPN3 Gene

mRNA expression in normal human tissues for OPN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPN3 Gene

SOURCE GeneReport for Unigene cluster for OPN3 Gene Hs.409081

mRNA Expression by UniProt/SwissProt for OPN3 Gene

Tissue specificity: Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.
genes like me logo Genes that share expression patterns with OPN3: view

Protein tissue co-expression partners for OPN3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for OPN3 Gene

Orthologs for OPN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OPN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPN3 35
  • 73.22 (n)
  • 65.15 (a)
(Canis familiaris)
Mammalia OPN3 35
  • 90.75 (n)
  • 91.1 (a)
OPN3 36
  • 92 (a)
(Mus musculus)
Mammalia Opn3 35
  • 84.75 (n)
  • 86 (a)
Opn3 16
Opn3 36
  • 88 (a)
(Pan troglodytes)
Mammalia OPN3 35
  • 99.59 (n)
  • 99.75 (a)
OPN3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Opn3 35
  • 85.5 (n)
  • 87 (a)
(Monodelphis domestica)
Mammalia OPN3 36
  • 57 (a)
(Gallus gallus)
Aves OPN3 35
  • 76.69 (n)
  • 73.98 (a)
OPN3 36
  • 71 (a)
(Anolis carolinensis)
Reptilia OPN3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494279 35
  • 56.2 (n)
  • 45.28 (a)
(Danio rerio)
Actinopterygii opn3 35
  • 64.22 (n)
  • 61.96 (a)
opn3 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta ninaE 36
  • 21 (a)
Rh2 36
  • 21 (a)
Rh3 36
  • 19 (a)
Rh4 36
  • 19 (a)
Rh5 36
  • 18 (a)
Rh6 36
  • 22 (a)
Rh7 36
  • 18 (a)
Species with no ortholog for OPN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN3 Gene

Gene Tree for OPN3 (if available)
Gene Tree for OPN3 (if available)

Paralogs for OPN3 Gene

Paralogs for OPN3 Gene

(4) SIMAP similar genes for OPN3 Gene using alignment to 4 proteins: Pseudogenes for OPN3 Gene

genes like me logo Genes that share paralogs with OPN3: view

Variants for OPN3 Gene

Sequence variations from dbSNP and Humsavar for OPN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12072790 - 241,604,453(+) CCCAC(A/G)CCAGT reference, missense
rs2273712 - 241,604,406(+) GTGTA(C/T)GTCCA reference, missense
rs593963 -- 241,618,178(-) AATTC(A/G)TGTTA intron-variant
rs595397 -- 241,640,863(+) AAACA(C/T)TGAAG upstream-variant-2KB
rs598292 -- 241,641,503(+) TCCAC(A/C)TTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OPN3 Gene

Variant ID Type Subtype PubMed ID
nsv873368 CNV Gain 21882294
nsv873372 CNV Gain 21882294
esv1007397 CNV Insertion 20482838
esv7009 CNV Gain 19470904
esv1555339 CNV Insertion 17803354
esv2726229 CNV Deletion 23290073
nsv159993 CNV Loss 16902084

Variation tolerance for OPN3 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OPN3 Gene

Disorders for OPN3 Gene

Relevant External Links for OPN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OPN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPN3 Gene

Publications for OPN3 Gene

  1. Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. (PMID: 10234000) Blackshaw S. … Snyder S.H. (J. Neurosci. 1999) 2 3 4 23 67
  2. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. (PMID: 11401433) Halford S. … Hunt D.M. (Genomics 2001) 2 3 23
  3. Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation. (PMID: 18344558) White J.H. … Pillai S.G. (Hum. Mol. Genet. 2008) 3 23
  4. Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. (PMID: 14623461) Alam N.A. … Tomlinson I.P.M. (Cancer Genet. Cytogenet. 2003) 3 23
  5. Different structural organization of the encephalopsin gene in man and mouse. (PMID: 12242008) Kasper G. … Rump A. (Gene 2002) 3 23

Products for OPN3 Gene

Sources for OPN3 Gene