OPN3 Gene

Aliases
for OPN3 gene

Previous GC identifers: GC01M239842 GC01M237209 GC01M238053 GC01M238797 GC01M238798 GC01M238082 GC01M212214

Summaries
for OPN3 gene

Genomic Views
for OPN3 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_167186.1  

SwitchGear Promoter luciferase reporter plasmid: OPN3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN3

OPN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M241753:  view genomic region     (about GC identifiers)

Proteins
for OPN3 gene

Explore the universe of human proteins at neXtProt for OPN3: NX_Q9H1Y3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: OPN3 OriGene Custom Protein Services for OPN3
	GenScript Custom Purified and Recombinant Proteins Services for OPN3
	Novus Biologicals OPN3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OPN3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of OPN3
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for OPN3
	GenScript Custom Superior Antibodies Services for OPN3
	Novus Biologicals OPN3 Antibodies
	Search for Antibodies for OPN3 at Abcam
	Uscn Antibodies for OPN3
	ThermoFisher Antibodies for OPN3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OPN3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OPN3

Protein Domains /
Families
for OPN3 gene

ProtoNet protein and cluster: Q9H1Y3

Function
for OPN3 gene

miRNA Products:		OriGene 3'-UTR Clone: OPN3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPN3
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate OPN3 (see all 12):
		hsa-miR-1237 hsa-miR-1267 hsa-miR-1248 hsa-miR-1227 hsa-miR-183* hsa-miR-659 hsa-miR-9 hsa-miR-377
		SwitchGear 3'UTR luciferase reporter plasmid: OPN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPN3 (see all 4) OriGene shRNA RFP: OPN3 OriGene siRNA: OPN3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPN3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for OPN3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPN3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPN3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OPN3 (NM_014322)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPN3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPN3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OPN3
		Search LifeMap BioReagents cell lines for OPN3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for OPN3 gene

	Super-pathway	contained gene-specific pathways
1	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 G alpha (i) signalling events 0.44 GPCR ligand binding 0.75 GPCRs, Class A Rhodopsin-like 0.41
2	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
3	Opsins	Opsins 1.00

1 BioSystems Pathway for OPN3

GPCRs, Class A Rhodopsin-like

5/7        Reactome Pathways for OPN3

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events
	GPCR ligand binding

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for OPN3 gene

Transcripts
for OPN3 gene

Expression
for OPN3 gene

OPN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTATATCT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPN3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPN3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPN3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPN3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN3

Orthologs
for OPN3 gene

Paralogs
for OPN3 gene

Paralogs for OPN3 gene

OPN1MW²  OPN1SW²  RHO²  RGR²  OPN4²  OPN1MW2²  RRH²  OPN1LW²  

OPN5²  

4 SIMAP similar genes for OPN3 using alignment to 4 protein entries:     OPN3_HUMAN (see all proteins):

OPN5    RHO    OPN4    RRH

OPN3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for OPN3
PGOHUM00000251100

Genomic Variants
for OPN3 gene

10/649 NCBI SNPs in OPN3 are shown (see all 649)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1461082381,2		--	241759465(+)	CATTGA/GCTGAG	1	--	int1		0	--	--	--	--
rs38417891,2	C,	--	241759493(+)	TGTTA-/GTTA           ATGTA	1	--	int1		0	--	--	--	--
rs1906092951,2		--	241759509(+)	TATTTC/TAATTT	1	--	int1		0	--	--	--	--
rs1401282161,2		--	241759523(+)	CTGTTG/TAGAGG	1	--	int1		0	--	--	--	--
rs1830524701,2		--	241759618(+)	AAAAAA/TTGTTA	1	--	int1		0	--	--	--	--
rs1448655151,2		--	241759629(+)	TAAAC-/AATTTCCA	1	--	int1		0	--	--	--	--
rs1871250981,2		--	241759635(+)	ATTTCC/TAGGGT	1	--	int1		0	--	--	--	--
rs731368821,2	C,F,	--	241760195(+)	GATAGC/TGGGTC	1	--	int1		2		WA CSA	4
rs669725511,2	C	--	241760300(+)	TTTTC-/TTTTTT	1	--	int1		1		NA	2
rs1115393751,2		--	241760438(+)	AGGAAG/ATTTCT	1	--	int1		1		CSA	2

HapMap Linkage Disequilibrium report for OPN3 (241753404 - 241840678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OPN3
     1 Indel: 59995

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPN3

DNA2.0 Custom Variant and Variant Library Synthesis for OPN3

Disorders / Diseases
for OPN3 gene

Publications
for OPN3 gene

PubMed articles for OPN3 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with OPN3)

Utopia: connect your pdf to the dynamic world of online information

1. Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. (PubMed id 10234000)^{1, 2, 3, 9} Blackshaw S. and Snyder S.H. (1999)
2. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. (PubMed id 11401433)^{1, 2, 3, 9} Halford S.... Hunt D.M. (2001)
3. Different structural organization of the encephalopsin gene in man and mouse. (PubMed id 12242008)^{1, 2, 9} Kasper G.... Rump A. (2002)
4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation. (PubMed id 18344558)^{1, 9} White J.H....Pillai S.G. (2008)
7. Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids. (PubMed id 12063405)^{1, 9} Halford S....Hunt D.M. (2001)
8. Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. (PubMed id 14623461)^{1, 9} Alam N.A.... Tomlinson I.P.M. (2003)
9. Opsin3 sensitizes hepatocellular carcinoma cells to 5- fluorouracil treatment by regulating the apoptotic pathway. (PubMed id 22313545)¹ Jiao J....Zhu C. (2012)
10. Follow-up examination of linkage and association to c hromosome 1q43 in multiple sclerosis. (PubMed id 19626040)¹ McCauley J.L....Haines J.L. (2009)

External Searches for OPN3 gene

Genome Databases showing OPN3 gene

Other Databases showing OPN3 gene

Specialized Databases showing OPN3 gene

Products
for OPN3 gene