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OPN1SW Gene

protein-coding   GIFtS: 59
GCID: GC07M128412

Opsin 1 (Cone Pigments), Short-Wave-Sensitive

(Previous name: blue cone photoreceptor pigment)
(Previous symbol: BCP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opsin 1 (Cone Pigments), Short-Wave-Sensitive1 2     CBT2 5
BCP1 2 3 5     Color Blindness1
Blue Cone Photoreceptor Pigment1 2 3     tritan1
Blue-Sensitive Opsin1 2 3     Short-Wave-Sensitive Opsin 12
BOP2 3     

External Ids:    HGNC: 10121   Entrez Gene: 6112   Ensembl: ENSG000001286177   OMIM: 6135225   UniProtKB: P039993   

Export aliases for OPN1SW gene to outside databases

Previous GC identifers: GC07M126889 GC07M127952 GC07M127966 GC07M128006 GC07M128199 GC07M122773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPN1SW Gene:
This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment
gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene
are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory
mechanisms while retaining those for red and green. Defective blue vision is characteristic. (provided by RefSeq,
Jul 2008)

GeneCards Summary for OPN1SW Gene:
OPN1SW (opsin 1 (cone pigments), short-wave-sensitive) is a protein-coding gene. Diseases associated with OPN1SW include color blindness, and colorblindness, tritan. GO annotations related to this gene include photoreceptor activity and G-protein coupled receptor activity. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: OPSB_HUMAN, P03999
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
opsin, covalently linked to cis-retinal

Gene Wiki entry for OPN1SW Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPN1SW gene promoter:
         GR   USF1   p53   AP-1   ATF-2   GR-beta   USF-1   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPN1SW promoter sequence
   Search Chromatin IP Primers for OPN1SW

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPN1SW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31.3-q32

OPN1SW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1SW gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M128412:  view genomic region     (about GC identifiers)

Start:
128,412,543 bp from pter      End:
128,415,844 bp from pter
Size:
3,302 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 127,795,527-127,798,828     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OPSB_HUMAN, P03999 (See protein sequence)
Recommended Name: Short-wave-sensitive opsin 1  
Size: 348 amino acids; 39135 Da
1 PDB 3D structure from and Proteopedia for OPN1SW:
1KPN (3D)    
Secondary accessions: Q13877

Explore the universe of human proteins at neXtProt for OPN1SW: NX_P03999

Explore proteomics data for OPN1SW at MOPED

Post-translational modifications: 

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1
  • Glycosylation2 at Asn14

  • See OPN1SW Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001699.1  
    ENSEMBL proteins: 
     ENSP00000249389  
    Reactome Protein details: P03999

    OPN1SW Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR001521 Opsin_blue
     IPR027430 Retinal_BS
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P03999

    ProtoNet protein and cluster: P03999

    2 Blocks protein domains:
    IPB001521 Blue-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSB_HUMAN, P03999
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    OPN1SW for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPSB_HUMAN, P03999
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
    opsin, covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=420 nm;

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS2937147
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0009881photoreceptor activity IEA--
         
    OPN1SW for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for OPN1SW:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Opn1sw):
     nervous system  vision/eye 

    OPN1SW for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPN1SW
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPN1SW
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPN1SW

    miRNA
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    miRTarBase miRNAs that target OPN1SW:
    hsa-mir-335-5p (MIRT017141)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPSB_HUMAN, P03999: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ----
    GO:0005887integral component of plasma membrane TAS9089077
    GO:0016021integral component of membrane ----
    GO:0042622photoreceptor outer segment membrane TAS--

    OPN1SW for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPN1SW About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    The retinoid cycle in cones (daylight vision)0.00
    Diseases associated with visual transduction0.43
    Retinoid cycle disease events0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Opsins
    Opsins
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OPN1SW
        GPCRs, Class A Rhodopsin-like

    4 Reactome Pathways for OPN1SW
        The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events
    G alpha (i) signalling events
    Opsins



    OPN1SW for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including OPN1SW: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OPN1SW

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for OPN1SW (ENSP000002493894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAT1ENSP000002324614STRING: ENSP00000232461
    GNAT2ENSP000002513374STRING: ENSP00000251337
    RHOENSP000002962714STRING: ENSP00000296271
    GNG2ENSP000003344484STRING: ENSP00000334448
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0007165signal transduction TAS2937147
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007601visual perception IEA--
    GO:0007602phototransduction TAS9089077

    OPN1SW for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OPN1SW (OPSB)

    2 Novoseek inferred chemical compound relationships for OPN1SW gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bacterioopsin 89.9 4 14653583 (2), 1479357 (1)
    bacteriorhodopsin 81.4 6 1479357 (1), 8932303 (1), 12586385 (1), 14653583 (1)



    OPN1SW for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OPN1SW gene: 
    NM_001708.2  

    Unigene Cluster for OPN1SW:

    Opsin 1 (cone pigments), short-wave-sensitive
    Hs.656404  [show with all ESTs]
    Unigene Representative Sequence: NM_001708
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000249389(uc003vnt.4)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: OPN1SW (NM_001708)
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      QuantiTect SYBR Green Assays in human, mouse, rat OPN1SW
      QuantiFast Probe-based Assays in human, mouse, rat OPN1SW

    Additional mRNA sequence: 

    DQ822478.1 M26172.1 

    3 DOTS entries:

    DT.95072231  DT.95202996  DT.121047092 

    10 AceView cDNA sequences:

    NM_001708 CR599610 BM666330 BM695152 CA420129 BQ189052 AW839178 M26172 
    BX369013 AL524418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OPN1SW expression in normal human tissues (normalized intensities)      OPN1SW embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCCCAG
    OPN1SW Expression
    About this image


    OPN1SW expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 10 entries
             Mature S Cone Cells Outer Nuclear Layer
             Retina-like cells
     
     NULL (Sensory Organs)    fully expand to see all 5 entries
             Retina-like cells
     
     Neurons
             Mature S Cone Cells Outer Nuclear Layer
    OPN1SW Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPN1SW Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656404

    UniProtKB/Swiss-Prot: OPSB_HUMAN, P03999
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

        Pathway & Disease-focused RT2 Profiler PCR Array including OPN1SW: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPN1SW gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Opn1sw1 , 5 opsin 1 (cone pigments), short-wave-sensitive (color more1, 5 86.98(n)1
    86.01(a)1
      6 (12.36 cM)5
    120571  NM_007538.31  NP_031564.11 
     293766715 
    chicken
    (Gallus gallus)
    Aves PRA16
    Gallus gallus rhodopsin (opsin 2, rod pigment) (re...
    46(a)
    many ↔ many
    26(4496441-4502013) ENSGALG00000002848
    lizard
    (Anolis carolinensis)
    Reptilia OPN1SW6
    opsin 1 (cone pigments), short-wave-sensitive
    84(a)
    1 ↔ 1
    GL343828.1(107252-120183)
    African clawed frog
    (Xenopus laevis)
    Amphibia opn1sw-A2 violet cone opsin 72.5(n)    U23463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii opn1sw22 opsin 1 (cone pigments), short-wave-sensitive, 2 77.16(n)   30582  AF109373.1 


    ENSEMBL Gene Tree for OPN1SW (if available)
    TreeFam Gene Tree for OPN1SW (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPN1SW gene
    OPN32  RGR2  OPN1MW22  OPN42  OPN1LW2  OPN1MW2  RHO2  RRH2  
    OPN52  
    5 SIMAP similar genes for OPN1SW using alignment to 2 protein entries:     OPSB_HUMAN (see all proteins):
    RHO    DKFZp781I1948    OPN1LW    OPN1MW    OPN1MW2

    OPN1SW for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPN1SW (see all 141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048940311,2,,4
    C,FTritan color blindness (CBT)4 pathogenic1131759069(-) CCTTCG/AGAGGC 2 /R /G mis12Minor allele frequency- A:0.00NA EU 5707
    VAR_0048394
    Tritan color blindness (CBT)4--see VAR_0048392 S P mis40--------
    VAR_0048404
    Tritan color blindness (CBT)4--see VAR_0048402 P S mis40--------
    rs1048940321,2
    Cpathogenic1131758058(-) CTCTCC/TCCCTC 2 P S mis10--------
    rs1115283801,2
    C,F--128413994(+) TCTGGA/GTGCTT 1 -- int12Minor allele frequency- G:0.04NA EU 1322
    rs567624131,2
    C--128413997(+) TTTTT-/TAATTT 1 -- int10--------
    rs732381051,2
    C,F--128414047(+) AGACCG/AAGTCT 1 -- int11Minor allele frequency- A:0.07NA 120
    rs1513027191,2
    --128414051(+) CGAGTC/TTCGCT 1 -- int10--------
    rs1861210081,2
    --128414082(+) GCAGTG/TGTGCA 1 -- int10--------
    rs454865051,2
    C--128414088(+) GTGCAG/ATCTCG 1 -- int16Minor allele frequency- A:0.15NA WA EA 364

    HapMap Linkage Disequilibrium report for OPN1SW (128412543 - 128415844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OPN1SW:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735137CNV Deletion23290073
    esv2670312CNV Deletion23128226
    nsv831125CNV Loss17160897
    esv22837CNV Gain19812545

    Human Gene Mutation Database (HGMD): OPN1SW
    Locus Specific Mutation Databases (LSDB): OPN1SW

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPN1SW
    DNA2.0 Custom Variant and Variant Library Synthesis for OPN1SW

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613522   
    OMIM disorders: 190900  
    UniProtKB/Swiss-Prot: OPSB_HUMAN, P03999
  • Tritan color blindness (CBT) [MIM:190900]: A disorder of vision characterized by a selective deficiency
    of blue spectral sensitivity. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 8 diseases for OPN1SW:    About MalaCards
    color blindness    colorblindness, tritan    blindness    retinal disease
    eye disease    retinitis    multiple myeloma    myeloma


    OPN1SW for disorders           About GeneDecksing

    Genetic Association Database (GAD): OPN1SW
    Human Genome Epidemiology (HuGE) Navigator: OPN1SW (1 document)

    Export disorders for OPN1SW gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPN1SW gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with OPN1SW)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. (PubMed id 1531728)1, 2, 4 Weitz C.J....Nathans J. (Am. J. Hum. Genet. 1992)
    2. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2, 3 Nathans J.... Hogness D.S. (Science 1986)
    3. Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. (PubMed id 8270261)1, 3, 9 Fitzgibbon J....Hunt D.M. (Hum. Genet. 1994)
    4. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    5. Sequences and evolution of human and squirrel monkey blue opsin genes. (PubMed id 9089077)1, 2 Shimmin L.C.... Li W.H. (J. Mol. Evol. 1997)
    6. Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment. (PubMed id 1386496)1, 2 Weitz C.J.... Nathans J. (Am. J. Hum. Genet. 1992)
    7. Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity. (PubMed id 2565599)1, 2 Sarkar G. and Sommer S.S. (Science 1989)
    8. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (Vision Res. 1986)
    9. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)
    10. Substitution of isoleucine for threonine at position 190 of S-opsin causes S-cone-function abnormalities. (PubMed id 23022137)1 Baraas R.C....Neitz M. (Vision Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 611 HGNC: 1012 AceView: OPN1SW Ensembl:ENSG00000128617 euGenes: HUgn611
    ECgene: OPN1SW H-InvDB: OPN1SW

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OPN1SW Pharmacogenomics, SNPs, Pathways
    Mutations of the color pigment geneshttp://www.retina-international.org/files/sci-news/cppmut.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPN1SW gene:
    Search GeneIP for patents involving OPN1SW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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