Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OPN1MW2 Gene

protein-coding   GIFtS: 41
GCID: GC0XP153485

Opsin 1 (Cone Pigments), Medium-Wave-Sensitive 2

  See OPN1MW2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Opsin 1 (Cone Pigments), Medium-Wave-Sensitive 21 2
Green Cone Photoreceptor Pigment2 3
Green-Sensitive Opsin2 3
GOP2 3
Medium-Wave-Sensitive Opsin 12
GCP3

External Ids:    HGNC: 269521   Entrez Gene: 7284582   Ensembl: ENSG000001661607   UniProtKB: P040013   

Export aliases for OPN1MW2 gene to outside databases

Previous GC identifers: GC0XU900626 GC0XP153138


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for OPN1MW2 Gene:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called
green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven
transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The
long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X
chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X
chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of
these genes. Defects in this gene are the cause of deutanopic colorblindness. (provided by RefSeq, Mar 2009)

GeneCards Summary for OPN1MW2 Gene:
OPN1MW2 (opsin 1 (cone pigments), medium-wave-sensitive 2) is a protein-coding gene. Diseases associated with OPN1MW2 include thyroid hormone resistance syndrome, and blue cone monochromacy. GO annotations related to this gene include photoreceptor activity and G-protein coupled receptor activity. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
opsin, covalently linked to cis-retinal




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPN1MW2 gene promoter:
         ER-alpha   AML1a   C/EBPalpha   GATA-1   GATA-2   CREB   MZF-1   deltaCREB   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OPN1MW2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPN1MW2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

OPN1MW2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1MW2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153485:  view genomic region     (about GC identifiers)

Start:
153,485,203 bp from pter      End:
153,498,755 bp from pter
Size:
13,553 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001 (See protein sequence)
Recommended Name: Medium-wave-sensitive opsin 1  
Size: 364 amino acids; 40584 Da
1 PDB 3D structure from and Proteopedia for OPN1MW2:
1KPW (3D)    

Explore the universe of human proteins at neXtProt for OPN1MW2: NX_P04001

Explore proteomics data for OPN1MW2 at MOPED

Post-translational modifications: 

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1
  • Glycosylation2 at Asn34

  • See OPN1MW2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001041646.1  
    ENSEMBL proteins: 
     ENSP00000358945   ENSP00000403023  
    Reactome Protein details: P04001

    OPN1MW2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OPN1MW2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OPN1MW2
    GenScript Custom Purified and Recombinant Proteins Services for OPN1MW2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for OPN1MW2 

    OPN1MW2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OPN1MW2
    Search for Antibodies for OPN1MW2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for OPN1MW2
    Search LSBio for Antibodies for OPN1MW2

    OPN1MW2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OPN1MW2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OPN1MW2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for OPN1MW2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR000378 Opsin_red/grn
     IPR027430 Retinal_BS
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04001

    ProtoNet protein and cluster: P04001

    2 Blocks protein domains:
    IPB000378 Red/green-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Find genes that share domains with OPN1MW2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPSG_HUMAN, P04001
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
    opsin, covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=530 nm;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0009881photoreceptor activity IEA--
         
    Find genes that share ontologies with OPN1MW2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPN1MW2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OPN1MW2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OPN1MW2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OPN1MW2

    miRNA
    Products:
        
    miRTarBase miRNAs that target OPN1MW2:
    hsa-mir-335-5p (MIRT017065)

    Block miRNA regulation of human, mouse, rat OPN1MW2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OPN1MW2:
    hsa-miR-3926
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OPN1MW2
    Predesigned siRNA for gene silencing in human, mouse, rat OPN1MW2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OPN1MW2

    Clone
    Products:
         
    OriGene clones in human, mouse for OPN1MW2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OPN1MW2 (NM_001048181)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPN1MW2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OPN1MW2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OPN1MW2
    Browse ESI BIO Cell Lines and PureStem Progenitors for OPN1MW2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN1MW2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OPSG_HUMAN, P04001: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005887integral component of plasma membrane TAS2937147
    GO:0016021integral component of membrane ----
    GO:0042622photoreceptor outer segment membrane TAS--

    Find genes that share ontologies with OPN1MW2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for OPN1MW2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    The retinoid cycle in cones (daylight vision)0.00
    Diseases associated with visual transduction0.43
    Retinoid cycle disease events0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Opsins
    Opsins
    5Disease
    Disease


    Find genes that share SuperPaths with OPN1MW2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OPN1MW2
        GPCRs, Class A Rhodopsin-like

    4 Reactome Pathways for OPN1MW2
        The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events
    G alpha (i) signalling events
    Opsins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OPN1MW2
    Interactions:

        Search GeneGlobe Interaction Network for OPN1MW2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for OPN1MW2 (P040013 ENSP000003589454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARR3P365753I2D: score=1 
    RANBP2P497923I2D: score=1 
    OPN4ENSP000003611414STRING: ENSP00000361141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0007186G-protein coupled receptor signaling pathway TAS2937147
    GO:0007601visual perception IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0018298protein-chromophore linkage IEA--

    Find genes that share ontologies with OPN1MW2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OPN1MW2 (OPSG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OPN1MW2 gene: 
    NM_001048181.2  

    Unigene Cluster for OPN1MW2:

    Opsin 1 (cone pigments), medium-wave-sensitive 2
    Hs.571751  [show with all ESTs]
    Unigene Representative Sequence: NM_001048181
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369929(uc004fkd.3) ENST00000488220 ENST00000430419
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OPN1MW2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate OPN1MW2:
    hsa-miR-3926
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OPN1MW2
    Predesigned siRNA for gene silencing in human, mouse, rat OPN1MW2
    Clone
    Products:
         
    OriGene clones in human, mouse for OPN1MW2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OPN1MW2 (NM_001048181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OPN1MW2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OPN1MW2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OPN1MW2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OPN1MW2
      QuantiTect SYBR Green Assays in human, mouse, rat OPN1MW2
      QuantiFast Probe-based Assays in human, mouse, rat OPN1MW2

    1 DOTS entry:

    DT.436489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OPN1MW2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCTGCCT
    OPN1MW2 Expression
    About this image

    OPN1MW2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPN1MW2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.571751

    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

        Custom PCR Arrays for OPN1MW2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OPN1MW2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OPN1MW2
    QuantiTect SYBR Green Assays in human, mouse, rat OPN1MW2
    QuantiFast Probe-based Assays in human, mouse, rat OPN1MW2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN1MW2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for OPN1MW2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OPNP6
    Gallus gallus opsin 1 (cone pigments), long-wave-s...
    47(a)
    many ↔ many
    19(7050569-7053364)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Red-sensitive opsin
    80(a)
    1 → many
    2(88664911-88668635)
    zebrafish
    (Danio rerio)
    Actinopterygii opn1lw16
    opn1lw26
    opsin 1 (cone pigments), long-wave-sensitive, 2
    77(a)
    77(a)
    many ↔ many
    many ↔ many
    11(26411202-26413596) ENSDARG00000044862
    11(26414605-26416765) ENSDARG00000044861
            Species with no ortholog for OPN1MW2

    ENSEMBL Gene Tree for OPN1MW2 (if available)
    TreeFam Gene Tree for OPN1MW2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OPN1MW2 gene
    LOC101060233  OPN1MW1 2  OPN32  RGR2  OPN42  OPN1LW2  OPN1SW2  RHO2  
    RRH2  OPN52  
    7 SIMAP similar genes for OPN1MW2 using alignment to 2 protein entries:     OPSG_HUMAN (see all proteins):
    DKFZp781I1948    OPN1LW    OPN1MW    OPN1SW    RHO    RRH
    OPN4

    Find genes that share paralogs with OPN1MW2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OPN1MW2 (see all 50)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848471731,2
    --153483485(+) AAAAAA/GGAGCG 1 -- us2k10--------
    rs1439243441,2
    C--153483740(+) GACTGC/TGCCAC 1 -- us2k10--------
    rs1506210471,2
    C--153483783(+) AAAAA-/AGTAAT 1 -- us2k10--------
    rs1138497211,2
    C--153484068(+) TACAAA/CAATTA 1 -- us2k10--------
    rs1402993771,2
    C--153484379(+) ACGACG/TAAAAA 1 -- us2k10--------
    rs2021061441,2
    C--153490638(+) CCCTAC/TGTGTG 2 T M mis10--------
    rs2002695651,2
    C--153490700(+) CTCAGC/TGGAAA 1 -- int10--------
    rs1416835321,2
    --153492493(+) ATTTCA/CAGTGT 1 -- int10--------
    rs1420764591,2
    C--153492772(+) CATTGC/TCTTCT 2 A V mis10--------
    rs1461892391,2
    C--153492783(+) CCTGGA/GTCTGG 2 I V mis10--------

    HapMap Linkage Disequilibrium report for OPN1MW2 (153485203 - 153498755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OPN1MW2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7161CNV Loss18451855
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    esv27518CNV Gain+Loss19812545
    nsv515186CNV Complex21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OPN1MW2
    DNA2.0 Custom Variant and Variant Library Synthesis for OPN1MW2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
  • Colorblindness, partial, deutan series (CBD) [MIM:303800]: A color vision defect characterized by a
    dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum.
    Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus
    green in protanopia. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Blue cone monochromacy (BCM) [MIM:303700]: A rare X-linked congenital stationary cone dysfunction
    syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive
    cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the
    remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity,
    pendular nystagmus, and photophobia. Patients often have myopia. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Cone dystrophy 5 (COD5) [MIM:303700]: A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies
    characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as
    indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies,
    particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and
    central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are
    distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 2 diseases for OPN1MW2:    
    About MalaCards
    thyroid hormone resistance syndrome    blue cone monochromacy

    2 diseases from the University of Copenhagen DISEASES database for OPN1MW2:
    Blue cone monochromacy     Thyroid hormone resistance syndrome

    Find genes that share disorders with OPN1MW2           About GenesLikeMe


    Export disorders for OPN1MW2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OPN1MW2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with OPN1MW2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. Defective colour vision associated with a missense mutation in the human green visual pigment gene. (PubMed id 1302020)1, 2 Winderickx J....Deeb S.S. (Nat. Genet. 1992)
    3. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2 Nathans J.... Hogness D.S. (Science 1986)
    4. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (Vision Res. 1986)
    5. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PubMed id 20579627)2 Gardner J.C....Hardcastle A.J. (Am. J. Hum. Genet. 2010)
    6. Expressions of rod and cone photoreceptor-like proteins in human epidermis. (PubMed id 19493002)1 Tsutsumi M....Denda M. (Exp. Dermatol. 2009)
    7. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    8. GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina. (PubMed id 12853434)1 Zhu X....Craft C.M. (J. Neurosci. 2003)
    9. Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. (PubMed id 12051694)2 Ueyama H.... Yamade S. (Biochem. Biophys. Res. Commun. 2002)
    10. Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype. (PubMed id 10319869)1 Hayashi T....Deeb S.S. (Nat. Genet. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 728458 HGNC: 26952 Ensembl:ENSG00000166160 euGenes: HUgn728458 ECgene: OPN1MW2
    H-InvDB: OPN1MW2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OPN1MW2 Pharmacogenomics, SNPs, Pathways
    Mutations of the color pigment geneshttp://www.retina-international.org/files/sci-news/cppmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=OPN1MW[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OPN1MW2 gene:
    Search GeneIP for patents involving OPN1MW2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OPN1MW2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OPN1MW2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OPN1MW2  
     OriGene qSTAR qPCR primer pairs in human, mouse for OPN1MW2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OPN1MW2   OriGene Custom Protein Services for OPN1MW2  

     
     
     Block miRNA regulation of human, mouse, rat OPN1MW2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OPN1MW2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPN1MW2 Predesigned siRNA for gene silencing in human, mouse, rat OPN1MW2
     QuantiFast Probe-based Assays in human, mouse, rat OPN1MW2 QuantiTect SYBR Green Assays in human, mouse, rat OPN1MW2
     Custom PCR Arrays for OPN1MW2 Search Chromatin IP Primers for OPN1MW2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OPN1MW2  Search GeneGlobe Interaction Network for OPN1MW2
     Regulatory tfbs in OPN1MW2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OPN1MW2 GenScript cDNA clones with any tag delivered in your preferred vector for OPN1MW2
     GenScript Custom Assay Services for OPN1MW2 GenScript Custom overexpressing Cell Line Services for OPN1MW2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OPN1MW2 (OPSG)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for OPN1MW2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for OPN1MW2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for OPN1MW2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPN1MW2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for OPN1MW2
     Browse SwitchGear Promoter luciferase reporter plasmids for OPN1MW2
     Search ThermoFisher Antibodies for OPN1MW2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OPN1MW2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPN1MW2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OPN1MW2
     Search LSBio for Antibodies for OPN1MW2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for OPN1MW2
      Search eBioscience for proteins for OPN1MW2
      Search eBioscience for elisas for OPN1MW2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OPN1MW2 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4