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Aliases for OPN1MW2 Gene

Aliases for OPN1MW2 Gene

  • Opsin 1 (Cone Pigments), Medium-Wave-Sensitive 2 2 3 5
  • Opsin 1 Cone Pigments Medium-Wave-Sensitive 2 3 4
  • Green Cone Photoreceptor Pigment 3 4
  • Green-Sensitive Opsin 3 4
  • GOP 3 4

External Ids for OPN1MW2 Gene

Previous GeneCards Identifiers for OPN1MW2 Gene

  • GC0XU900626
  • GC0XP153138
  • GC0XP153485

Summaries for OPN1MW2 Gene

Entrez Gene Summary for OPN1MW2 Gene

  • This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]

GeneCards Summary for OPN1MW2 Gene

OPN1MW2 (Opsin 1 (Cone Pigments), Medium-Wave-Sensitive 2) is a Protein Coding gene. Diseases associated with OPN1MW2 include Blue Cone Monochromacy and Achromatopsia. Among its related pathways are Peptide ligand-binding receptors and Opsins. GO annotations related to this gene include G-protein coupled receptor activity and photoreceptor activity. An important paralog of this gene is OPN1SW.

UniProtKB/Swiss-Prot for OPN1MW2 Gene

  • Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN1MW2 Gene

Genomics for OPN1MW2 Gene

Regulatory Elements for OPN1MW2 Gene

Enhancers for OPN1MW2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPN1MW2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OPN1MW2 Gene

154,219,734 bp from pter
154,233,286 bp from pter
13,553 bases
Plus strand

Genomic View for OPN1MW2 Gene

Genes around OPN1MW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPN1MW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPN1MW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN1MW2 Gene

Proteins for OPN1MW2 Gene

  • Protein details for OPN1MW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Medium-wave-sensitive opsin 2
    Protein Accession:

    Protein attributes for OPN1MW2 Gene

    364 amino acids
    Molecular mass:
    40584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OPN1MW2 Gene

Proteomics data for OPN1MW2 Gene at MOPED

Post-translational modifications for OPN1MW2 Gene

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Other Protein References for OPN1MW2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN1MW2 Gene

Domains & Families for OPN1MW2 Gene

Gene Families for OPN1MW2 Gene

Protein Domains for OPN1MW2 Gene

Suggested Antigen Peptide Sequences for OPN1MW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN1MW2: view

Function for OPN1MW2 Gene

Molecular function for OPN1MW2 Gene

UniProtKB/Swiss-Prot Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
genes like me logo Genes that share phenotypes with OPN1MW2: view

Animal Model Products

CRISPR Products

miRNA for OPN1MW2 Gene

miRTarBase miRNAs that target OPN1MW2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPN1MW2 Gene

Localization for OPN1MW2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN1MW2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OPN1MW2 Gene COMPARTMENTS Subcellular localization image for OPN1MW2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for OPN1MW2 Gene

Pathways & Interactions for OPN1MW2 Gene

genes like me logo Genes that share pathways with OPN1MW2: view

Pathways by source for OPN1MW2 Gene

Interacting Proteins for OPN1MW2 Gene

Gene Ontology (GO) - Biological Process for OPN1MW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007601 visual perception IEA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0071482 cellular response to light stimulus IBA --
genes like me logo Genes that share ontologies with OPN1MW2: view

No data available for SIGNOR curated interactions for OPN1MW2 Gene

Drugs & Compounds for OPN1MW2 Gene

No Compound Related Data Available

Transcripts for OPN1MW2 Gene

mRNA/cDNA for OPN1MW2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPN1MW2 Gene

Opsin 1 (cone pigments), medium-wave-sensitive 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPN1MW2 Gene

No ASD Table

Relevant External Links for OPN1MW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPN1MW2 Gene

mRNA expression in normal human tissues for OPN1MW2 Gene

SOURCE GeneReport for Unigene cluster for OPN1MW2 Gene Hs.571751

genes like me logo Genes that share expression patterns with OPN1MW2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OPN1MW2 Gene

Orthologs for OPN1MW2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN1MW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPN1LW 36
  • 89 (a)
(Canis familiaris)
Mammalia OPN1LW 36
  • 87 (a)
(Monodelphis domestica)
Mammalia OPN1LW 36
  • 83 (a)
(Mus musculus)
Mammalia Opn1mw 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia OPN1LW 36
  • 85 (a)
(Gallus gallus)
Aves OPNP 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
(Danio rerio)
Actinopterygii opn1lw1 36
  • 77 (a)
opn1lw2 36
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
CSA.11297 36
  • 39 (a)
Species with no ortholog for OPN1MW2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN1MW2 Gene

Gene Tree for OPN1MW2 (if available)
Gene Tree for OPN1MW2 (if available)

Paralogs for OPN1MW2 Gene

Paralogs for OPN1MW2 Gene

(7) SIMAP similar genes for OPN1MW2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OPN1MW2: view

Variants for OPN1MW2 Gene

Sequence variations from dbSNP and Humsavar for OPN1MW2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1065427 -- 154,230,623(+) TGATG(A/G)TCCTG reference, missense
rs1065430 -- 154,230,626(+) TGGTC(C/T)TGGCA reference, synonymous-codon
rs1065432 -- 154,230,628(+) GTCCT(G/T)GCATT reference, synonymous-codon
rs1065433 -- 154,230,631(+) CTGGC(A/G)TTCTG reference, synonymous-codon
rs1065434 -- 154,230,633(+) GGCAT(A/T)CTGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OPN1MW2 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680
nsv7161 CNV Loss 18451855
esv27518 CNV Gain+Loss 19812545
nsv515186 CNV Complex 21397061

Variation tolerance for OPN1MW2 Gene

Gene Damage Index Score: 0.18; 3.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OPN1MW2 Gene

Disorders for OPN1MW2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OPN1MW2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
blue cone monochromacy
  • blue cone monochromatism
  • achm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OPN1MW2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OPN1MW2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPN1MW2 Gene

Publications for OPN1MW2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. G protein-coupled receptors participate in cytokinesis. (PMID: 22888021) Zhang X. … Eggert U.S. (Cytoskeleton (Hoboken) 2012) 3
  3. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PMID: 20579627) Gardner J.C. … Hardcastle A.J. (Am. J. Hum. Genet. 2010) 3
  4. Expressions of rod and cone photoreceptor-like proteins in human epidermis. (PMID: 19493002) Tsutsumi M. … Denda M. (Exp. Dermatol. 2009) 3
  5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3

Products for OPN1MW2 Gene

Sources for OPN1MW2 Gene