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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPN1MW Gene

protein-coding   GIFtS: 59
GCID: GC0XP153448

opsin 1 (cone pigments), medium-wave-sensitive

(Previous names: color blindness, deutan, green cone photoreceptor pigment...)
(Previous symbols: GCP, CBBM, CBD)
 Explore 15 diseases affiliated with
OPN1MW via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OPN1MW    

Aliases
for OPN1MW gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Opsin 1 (Cone Pigments), Medium-Wave-Sensitive1 2     Green-Sensitive Opsin2 3
GCP1 2 3 5     GOP2 3
Green Cone Photoreceptor Pigment1 2 3     Color Blindness, Deutan1
CBBM1 2 5     Cone Dystrophy 5 (X-Linked)2
CBD1 2 5     Green Cone Pigment2
COD51 2     Medium-Wave-Sensitive Opsin 12
OPN1MW11 2     Photopigment Apoprotein2

External Ids:    HGNC: 42061   Entrez Gene: 26522   Ensembl: ENSG000001473807   OMIM: 3008215   UniProtKB: P040013   

Export aliases for OPN1MW gene to outside databases

Previous GC identifers: GC0XP148439 GC0XP150757 GC0XP151033 GC0XP151953 GC0XP151917 GC0XP152969 GC0XP153101


Summaries
for OPN1MW gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OPN1MW:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green
cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven
transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength
opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and
frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions
of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are
the cause of deutanopic colorblindness. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
covalently linked to cis-retinal

Gene Wiki entry for OPN1MW


Genomic Views
for OPN1MW gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPN1MW gene promoter:
         ER-alpha   CREB   p53   deltaCREB   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OPN1MW promoter sequence
   Search SABiosciences Chromatin IP Primers for OPN1MW

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN1MW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

OPN1MW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1MW gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153448:  view genomic region     (about GC identifiers)

Start:
 153,448,085 bp from pter      End:
 153,462,352 bp from pter
Size:
 14,268 bases      Orientation:
 plus strand

Proteins
for OPN1MW gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001 (See protein sequence)
Recommended Name: Medium-wave-sensitive opsin 1  
Size: 364 amino acids; 40584 Da
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for OPN1MW:
1KPW (3D)    

Explore the universe of human proteins at neXtProt for OPN1MW: NX_P04001

Post-translational modifications:

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04001

    • OPN1MW Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000504.1  
    ENSEMBL proteins: 
     ENSP00000358951   ENSP00000394838  
    Reactome Protein details: P04001
    Human Recombinant Protein Products: 
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    Uscn Proteins for OPN1MW

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ----


    OPN1MW for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for OPN1MW gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OPN1MW for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR000378 Opsin_red/grn
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04001

    ProtoNet protein and cluster: P04001

    2 Blocks protein families:
    IPB000378 Red/green-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Function
    for OPN1MW gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
    covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=530 nm;

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OPN1MW
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OPN1MW:
    hsa-miR-221* hsa-miR-3926 hsa-miR-320e hsa-miR-324-3p hsa-miR-1207-5p hsa-miR-335
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0009881photoreceptor activity ----


    OPN1MW for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for OPN1MW:
     Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Opn1mw):
     vision/eye 

    OPN1MW for phenotypes           About GeneDecksing


    Pathways & Interactions
    for OPN1MW gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		GPCRs, Class A Rhodopsin-like0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for OPN1MW 
        GPCRs, Class A Rhodopsin-like

    5/15        Reactome Pathways for OPN1MW (see all 15)
        Diseases associated with visual transduction
    GPCR downstream signaling
    The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events
    Signaling by GPCR



    OPN1MW for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPN1MW

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for OPN1MW (P040013 ENSP000003589514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP2P497923, ENSP000002831954I2D: score=1 STRING: ENSP00000283195
    ARR3P365753, ENSP000003115384I2D: score=1 STRING: ENSP00000311538
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007601visual perception ----
    GO:0007602phototransduction ----
    GO:0018298protein-chromophore linkage ----


    OPN1MW for ontologies           About GeneDecksing



    Drugs & Compounds
    for OPN1MW gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OPN1MW
    Search CenterWatch for drugs/clinical trials and news about OPN1MW / OPSG 

    Transcripts
    for OPN1MW gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OPN1MW gene: 
    NM_000513.2  

    Unigene Cluster for OPN1MW:

    Opsin 1 (cone pigments), medium-wave-sensitive
    Hs.247787  [show with all ESTs]
    Unigene Representative Sequence: NM_000513
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369935(uc004fkb.3) ENST00000468495 ENST00000430054

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OPN1MW:
    hsa-miR-221* hsa-miR-3926 hsa-miR-320e hsa-miR-324-3p hsa-miR-1207-5p hsa-miR-335
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPN1MW (see all 7)
    OriGene shRNA RFP: OPN1MW
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPN1MW
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPN1MW

    Additional cDNA sequence: 

    BC140938.1 BC143790.1 BC171754.1 BC171755.1 

    2 DOTS entries:

    DT.436489  DT.95288742 

    1 AceView cDNA sequence:

    NM_000513 

    GeneLoc Exon Structure


    Expression
    for OPN1MW gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPN1MW expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCAGGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OPN1MW expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature M Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature M-S Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature S Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerRod Precursor CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerCone Precursor CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Photoreceptor-like cells (Generation of retina...)Eye

    See OPN1MW Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPN1MW

    SOURCE GeneReport for Unigene cluster: Hs.247787

    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

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    In Situ
    Assay Products:     
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    Orthologs
    for OPN1MW gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OPN1MW gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OPN1LW6
    		 pinopsin
    		 46(a)
    		 possible ortholog
    		 19(6999227-7002022)
    lizard
    (Anolis carolinensis)    		 Reptilia OPSR_ANOCA6
    --
    (see all 4)    		 --
    		 80(a)
    52(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 2(88664911-88668635)
    AAWZ02040148(1849-6661)
    zebrafish
    (Danio rerio)    		 Actinopterygii opn1lw16
    opn1lw26
    (see all 4)    		 opsin 1 (cone pigments), long-wave-sensitive, 2
    (see all 4)    		 77(a)
    77(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 11(26411202-26413596)
    11(26414605-26416765)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 Pteropsin
    		 24(a)
    		 1 → many
    		 Group9.2(283911-292747)


    ENSEMBL Gene Tree for OPN1MW (if available)
    TreeFam Gene Tree for OPN1MW (if available) 

    Paralogs
    for OPN1MW gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPN1MW gene
    OPN1MW21 2  OPN32  OPN1SW2  RHO2  RGR2  OPN42  RRH2  OPN1LW2  
    OPN52  
    7 SIMAP similar genes for OPN1MW using alignment to 3 protein entries:     OPSG_HUMAN (see all proteins):
    DKFZp781I1948    OPN1LW    OPN1MW2    OPN1SW    RHO    RRH
    OPN4

    OPN1MW for paralogs           About GeneDecksing



    Genomic Variants
    for OPN1MW gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/21 NCBI SNPs in OPN1MW are shown (see all 21)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048949141,2
    		Cpathogenic153457207(+) CTTCAC/TGCGGC 2 R C mis10--------
    rs1834748411,2
    		--153448992(+) GTGACC/TGCCCC 1 -- int10--------
    rs1048949151,2
    		C--153453428(+) GTGAAA/CCTGGC 2 K N mis10--------
    rs20716931,2
    		C--153453609(+) CAAGCC/TCCTCC 1 -- int10--------
    rs1048949161,2
    		C--153461425(+) GTTTCA/GAAACT 2 Q R mis10--------
    rs2020489651,2
    		----153461494(+) CAAAAC/TGGAGG 2 T M mis10--------
    rs2000065491,2
    		----153453566(+) CCAGTC/TGGGGC 1 -- int10--------
    rs1409930601,2
    		----153455282(+) CACCTC/GTATGA 1 -- int10--------
    rs2004701201,2
    		----153453477(+) TCAGCA/GTTGTG 2 I V mis10--------
    rs1473194551,2
    		----153446969(+) GTGGTA/GCACAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OPN1MW (153448085 - 153462352 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for OPN1MW
         4 CNVs: 97108 83868 37014 74085
    Human Gene Mutation Database (HGMD): OPN1MW

    Locus Specific Mutation Databases (LSDB): OPN1MW

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPN1MW
    DNA2.0 Custom Variant and Variant Library Synthesis for OPN1MW

    Disorders / Diseases
    for OPN1MW gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OPN1MW for disorders           About GeneDecksing

    OMIM gene information: 300821   
    OMIM disorders: 303800  303700  
    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
  • Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD) [MIM:303800]; also known as
    • deuteranopia
  • Defects in OPN1MW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital
    • stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium
    wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived
    from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity,
    pendular nystagmus, and photophobia. Patients often have myopia
  • Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5) [MIM:303700]. A X-linked cone dystrophy. Cone
    • dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with
    preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some
    cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity,
    color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies
    are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs

    15 diseases for OPN1MW:    About MalaCards
    red-green color vision defects    color blindness    colorblindness, deutan    cone dystrophy
    blue cone monochromacy    blindness    cone-rod dystrophy    color vision deficiency
    beta thalassemia    retinitis pigmentosa    gastric dilatation    nystagmus
    myopia    thalassemia    retinitis

    2 diseases from the University of Copenhagen DISEASES database for OPN1MW:
    Blue cone monochromacy     Thyroid hormone resistance syndrome
    GeneTests: OPN1MW
    Red-Green Color Vision Defects

    Human Genome Epidemiology (HuGE) Navigator: OPN1MW (1 document)

    Export disorders for OPN1MW gene to outside databases

    Publications
    for OPN1MW gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPN1MW gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with OPN1MW)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PubMed id 20579627)1, 2 Gardner J.C....Hardcastle A.J. (2010)
    2. Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. (PubMed id 12051694)1, 2 Ueyama H....Yamade S. (2002)
    3. Defective colour vision associated with a missense mutation in the human green visual pigment gene. (PubMed id 1302020)1, 2 Winderickx J....Deeb S.S. (1992)
    4. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (1986)
    5. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2 Nathans J.... Hogness D.S. (1986)
    6. Gene conversion between red and defective green opsin gene in blue cone monochromacy. (PubMed id 8666378)2, 9 Reyniers E....Willems P.J. (1995)
    7. The effect of cone opsin mutations on retinal structur e and the integrity of the photoreceptor mosaic. (PubMed id 23139274)1 Carroll J....Michaelides M. (2012)
    8. A novel missense mutation in both OPN1LW and OPN1MW co ne opsin genes causes X-linked cone dystrophy (XLCOD5). (PubMed id 22183383)1 Gardner J.C....Hardcastle A.J. (2012)
    9. Clinical utility gene card for: blue cone monochromat ism. (PubMed id 21267011)1 Kohl S. and Hamel C.P. (2011)
    10. Variable retinal phenotypes caused by mutations in th e X-linked photopigment gene array. (PubMed id 20220053)1 Mizrahi-Meissonnier L....Sharon D. (2010)

    External Searches for OPN1MW gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OPN1MW gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2652 HGNC: 4206 AceView: OPN1MW Ensembl:ENSG00000147380 euGenes: HUgn2652
    ECgene: OPN1MW H-InvDB: OPN1MW

    Other Databases showing OPN1MW gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OPN1MW gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPN1MW Pharmacogenomics, SNPs, Pathways
    Mutations of the color pigment geneshttp://www.retina-international.org/files/sci-news/cppmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPN1MW

    Intellectual Property
    for OPN1MW gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OPN1MW gene:
    Search GeneIP for patents involving OPN1MW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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