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OPN1MW Gene

protein-coding   GIFtS: 59
GCID: GC0XP153448

Opsin 1 (Cone Pigments), Medium-Wave-Sensitive

(Previous names: color blindness, deutan, green cone photoreceptor pigment)
(Previous symbols: GCP, CBBM, CBD)
  See OPN1MW-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Opsin 1 (Cone Pigments), Medium-Wave-Sensitive1 2     GOP2 3
GCP1 2 3 5     Color Blindness, Deutan1
Green Cone Photoreceptor Pigment1 2 3     COD52
CBBM1 2 5     OPN1MW12
CBD1 2 5     Green Cone Pigment2
Cone Dystrophy 5 (X-Linked)1 2     Medium-Wave-Sensitive Opsin 12
Green-Sensitive Opsin2 3     Photopigment Apoprotein2

External Ids:    HGNC: 42061   Entrez Gene: 26522   Ensembl: ENSG000001473807   OMIM: 3008215   UniProtKB: P040013   

Export aliases for OPN1MW gene to outside databases

Previous GC identifers: GC0XP148439 GC0XP150757 GC0XP151033 GC0XP151953 GC0XP151917 GC0XP152969 GC0XP153101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OPN1MW Gene:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called
green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven
transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The
long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X
chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X
chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of
these genes. Defects in this gene are the cause of deutanopic colorblindness. (provided by RefSeq, Mar 2009)

GeneCards Summary for OPN1MW Gene:
OPN1MW (opsin 1 (cone pigments), medium-wave-sensitive) is a protein-coding gene. Diseases associated with OPN1MW include blue-mono-cone-monochromatic type colorblindness, and blue cone monochromatism. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
opsin, covalently linked to cis-retinal

Gene Wiki entry for OPN1MW Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OPN1MW gene promoter:
         ER-alpha   CREB   p53   deltaCREB   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOPN1MW promoter sequence
   Search Chromatin IP Primers for OPN1MW

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OPN1MW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

OPN1MW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1MW gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153448:  view genomic region     (about GC identifiers)

Start:
153,448,085 bp from pter      End:
153,462,352 bp from pter
Size:
14,268 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001 (See protein sequence)
Recommended Name: Medium-wave-sensitive opsin 1  
Size: 364 amino acids; 40584 Da
1 PDB 3D structure from and Proteopedia for OPN1MW:
1KPW (3D)    

Explore the universe of human proteins at neXtProt for OPN1MW: NX_P04001

Explore proteomics data for OPN1MW at MOPED

Post-translational modifications: 

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1
  • Modification sites at neXtProt

  • See OPN1MW Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000504.1  
    ENSEMBL proteins: 
     ENSP00000358951   ENSP00000394838  
    Reactome Protein details: P04001

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR000378 Opsin_red/grn
     IPR027430 Retinal_BS
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04001

    ProtoNet protein and cluster: P04001

    2 Blocks protein domains:
    IPB000378 Red/green-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Find genes that share domains with OPN1MW           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPSG_HUMAN, P04001
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein,
    opsin, covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=530 nm;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0009881photoreceptor activity ----
         
    Find genes that share ontologies with OPN1MW           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OPN1MW:
     Increased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Opn1mw):
     vision/eye 

    Find genes that share phenotypes with OPN1MW           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OPN1MW
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    miRNA
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    miRTarBase miRNAs that target OPN1MW:
    hsa-mir-335-5p (MIRT017886)

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    6 qRT-PCR Assays for microRNAs that regulate OPN1MW:
    hsa-miR-221* hsa-miR-3926 hsa-miR-320e hsa-miR-324-3p hsa-miR-1207-5p hsa-miR-335
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OPSG_HUMAN, P04001: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane ----
    GO:0016021integral component of membrane ----
    GO:0042622photoreceptor outer segment membrane ----

    Find genes that share ontologies with OPN1MW           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OPN1MW About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    The retinoid cycle in cones (daylight vision)0.00
    Diseases associated with visual transduction0.43
    Retinoid cycle disease events0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Opsins
    Opsins
    5Disease
    Disease


    Find genes that share SuperPaths with OPN1MW           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OPN1MW
        GPCRs, Class A Rhodopsin-like

    4 Reactome Pathways for OPN1MW
        The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events
    G alpha (i) signalling events
    Opsins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OPN1MW
    Interactions:

        GeneGlobe Interaction Network for OPN1MW

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OPN1MW (P040013 ENSP000003589514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP2P497923, ENSP000002831954I2D: score=1 STRING: ENSP00000283195
    ARR3P365753, ENSP000003115384I2D: score=1 STRING: ENSP00000311538
    OPN4ENSP000003611414STRING: ENSP00000361141
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007601visual perception ----
    GO:0007603phototransduction, visible light ----
    GO:0018298protein-chromophore linkage ----

    Find genes that share ontologies with OPN1MW           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OPN1MW (OPSG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OPN1MW gene: 
    NM_000513.2  

    Unigene Cluster for OPN1MW:

    Opsin 1 (cone pigments), medium-wave-sensitive
    Hs.247787  [show with all ESTs]
    Unigene Representative Sequence: NM_000513
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369935(uc004fkb.3) ENST00000468495 ENST00000430054
    miRNA
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    hsa-miR-221* hsa-miR-3926 hsa-miR-320e hsa-miR-324-3p hsa-miR-1207-5p hsa-miR-335
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    BC140938.1 BC143790.1 BC171754.1 BC171755.1 

    2 DOTS entries:

    DT.436489  DT.95288742 

    1 AceView cDNA sequence:

    NM_000513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OPN1MW expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGGTGC
    OPN1MW Expression
    About this image


    OPN1MW expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Mature M-S Cone Cells Outer Nuclear Layer
             Retina
             Photoreceptor-like cells
     
     Neurons
             Mature M-S Cone Cells Outer Nuclear Layer
     
     NULL (Sensory Organs)
             Photoreceptor-like cells
    OPN1MW Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OPN1MW Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247787

    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OPN1MW gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Opn1mw5 opsin 1 (cone pigments), medium-wave-sensitive (color more   --   X (37.76 cM) 74127464 
    chicken
    (Gallus gallus)
    Aves OPNP6
    Gallus gallus opsin 1 (cone pigments), long-wave-s...
    47(a)
    many ↔ many
    19(7050569-7053364)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Red-sensitive opsin
    80(a)
    1 → many
    2(88664911-88668635)
    zebrafish
    (Danio rerio)
    Actinopterygii opn1lw26
    opn1lw16
    opsin 1 (cone pigments), long-wave-sensitive, 1
    77(a)
    77(a)
    many ↔ many
    many ↔ many
    11(26414605-26416765) ENSDARG00000044861
    11(26411202-26413596) ENSDARG00000044862


    ENSEMBL Gene Tree for OPN1MW (if available)
    TreeFam Gene Tree for OPN1MW (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OPN1MW gene
    LOC101060233  OPN1MW21 2  OPN32  RGR2  OPN42  OPN1LW2  OPN1SW2  RHO2  
    RRH2  OPN52  
    7 SIMAP similar genes for OPN1MW using alignment to 3 protein entries:     OPSG_HUMAN (see all proteins):
    DKFZp781I1948    OPN1LW    OPN1MW2    OPN1SW    RHO    RRH
    OPN4

    Find genes that share paralogs with OPN1MW           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OPN1MW (see all 45)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0640534
    Colorblindness, partial, deutan series (CBD)4--see VAR_0640532 R Q mis40--------
    VAR_0048414
    Colorblindness, partial, deutan series (CBD)4--see VAR_0048412 C R mis40--------
    VAR_0640524
    Cone dystrophy 5 (COD5)4--see VAR_0640522 W R mis40--------
    VAR_0640514
    Colorblindness, partial, deutan series (CBD)4--see VAR_0640512 N K mis40--------
    rs1048949151,2
    Cpathogenic1153359508(+) GTGAAA/CCTGGC 2 K N mis10--------
    rs1048949141,2
    Cpathogenic1153363287(+) CTTCAC/TGCGGC 2 R C mis10--------
    rs1048949161,2
    Cpathogenic1153367505(+) GTTTCA/GAAACT 2 Q R mis10--------
    rs1834748411,2
    --153355072(+) GTGACC/TGCCCC 1 -- int10--------
    rs19849661,2
    C--153358010(+) ggcaaG/Catagc 1 -- int11Minor allele frequency- C:0.50NA 2
    rs2006752501,2
    C--153358010(+) GGCAAC/GATAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for OPN1MW (153448085 - 153462352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OPN1MW:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7161CNV Loss18451855
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    esv27518CNV Gain+Loss19812545
    nsv515186CNV Complex21397061

    Human Gene Mutation Database (HGMD): OPN1MW
    Locus Specific Mutation Databases (LSDB): OPN1MW

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing OPN1MW
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300821   
    OMIM disorders: 303800  303700  
    UniProtKB/Swiss-Prot: OPSG_HUMAN, P04001
  • Colorblindness, partial, deutan series (CBD) [MIM:303800]: A color vision defect characterized by a
    dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum.
    Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus
    green in protanopia. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Blue cone monochromacy (BCM) [MIM:303700]: A rare X-linked congenital stationary cone dysfunction
    syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive
    cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the
    remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity,
    pendular nystagmus, and photophobia. Patients often have myopia. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Cone dystrophy 5 (COD5) [MIM:303700]: A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies
    characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as
    indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies,
    particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and
    central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are
    distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 9 diseases for OPN1MW:    
    About MalaCards
    blue-mono-cone-monochromatic type colorblindness    blue cone monochromatism    colorblindness, deutan    red-green color vision defects
    blue cone monochromacy    cone dystrophy    thyroid hormone resistance syndrome    color blindness
    cone-rod dystrophy 2

    2 diseases from the University of Copenhagen DISEASES database for OPN1MW:
    Blue cone monochromacy     Thyroid hormone resistance syndrome

    Find genes that share disorders with OPN1MW           About GenesLikeMe

    GeneTests: OPN1MW
    GeneReviews: OPN1MW
    Genetic Association Database (GAD): OPN1MW
    Human Genome Epidemiology (HuGE) Navigator: OPN1MW (1 document)

    Export disorders for OPN1MW gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OPN1MW gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with OPN1MW)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Defective colour vision associated with a missense mutation in the human green visual pigment gene. (PubMed id 1302020)1, 2, 4 Winderickx J....Deeb S.S. (Nat. Genet. 1992)
    2. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PubMed id 20579627)1, 2 Gardner J.C....Hardcastle A.J. (Am. J. Hum. Genet. 2010)
    3. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    4. Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. (PubMed id 12051694)1, 2 Ueyama H.... Yamade S. (Biochem. Biophys. Res. Commun. 2002)
    5. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (Vision Res. 1986)
    6. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2 Nathans J.... Hogness D.S. (Science 1986)
    7. Gene conversion between red and defective green opsin gene in blue cone monochromacy. (PubMed id 8666378)2, 9 Reyniers E.... Willems P.J. (Genomics 1995)
    8. Blue cone monochromatism in a female due to skewed X-inactivation. (PubMed id 22998501)1 Frederiksen A.L....Welinder L.G. (Ophthalmic Genet. 2013)
    9. The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic. (PubMed id 23139274)1 Carroll J....Michaelides M. (amp 2012)
    10. A novel missense mutation in both OPN1LW and OPN1MW cone opsin genes causes X-linked cone dystrophy (XLCOD5). (PubMed id 22183383)1 Gardner J.C....Hardcastle A.J. (Adv. Exp. Med. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2652 HGNC: 4206 AceView: OPN1MW Ensembl:ENSG00000147380 euGenes: HUgn2652
    ECgene: OPN1MW H-InvDB: OPN1MW

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OPN1MW Pharmacogenomics, SNPs, Pathways
    Mutations of the color pigment geneshttp://www.retina-international.org/files/sci-news/cppmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=OPN1MW[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OPN1MW gene:
    Search GeneIP for patents involving OPN1MW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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