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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OPN1LW Gene

protein-coding   GIFtS: 56
GCID: GC0XP153409

opsin 1 (cone pigments), long-wave-sensitive

(Previous names: color blindness, protan, red cone photoreceptor pigment...)
(Previous symbols: CBBM, RCP, CBP)
 Explore 23 diseases affiliated with
OPN1LW via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OPN1LW    

Aliases
for OPN1LW gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Opsin 1 (Cone Pigments), Long-Wave-Sensitive1 2     Red-Sensitive Opsin2 3
RCP1 2 3 5     ROP2 3
Red Cone Photoreceptor Pigment1 2 3     Color Blindness, Protan1
CBBM1 2 5     Cone Dystrophy 5 (X-Linked)2
CBP1 2 5     Long-Wave-Sensitive Opsin 12
COD51 2     

External Ids:    HGNC: 99361   Entrez Gene: 59562   Ensembl: ENSG000001020767   OMIM: 3008225   UniProtKB: P040003   

Export aliases for OPN1LW gene to outside databases

Previous GC identifers: GC0XP147547 GC0XP149864 GC0XP150995 GC0XP151916 GC0XP151877 GC0XP152930 GC0XP153062 GC0XP142061


Summaries
for OPN1LW gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OPN1LW:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone
photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane
domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength
opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur
between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have
more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
covalently linked to cis-retinal

Gene Wiki entry for OPN1LW


Genomic Views
for OPN1LW gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPN1LW gene promoter:
         AML1a   Sp1   Evi-1   GATA-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OPN1LW promoter sequence
   Search SABiosciences Chromatin IP Primers for OPN1LW

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPN1LW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

OPN1LW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1LW gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153409:  view genomic region     (about GC identifiers)

Start:
 153,409,698 bp from pter      End:
 153,424,507 bp from pter
Size:
 14,810 bases      Orientation:
 plus strand

Proteins
for OPN1LW gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000 (See protein sequence)
Recommended Name: Long-wave-sensitive opsin 1  
Size: 364 amino acids; 40572 Da
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for OPN1LW:
1KPX (3D)    

Explore the universe of human proteins at neXtProt for OPN1LW: NX_P04000

Post-translational modifications:

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1
  • View neXtProt modification sites for NX_P04000

    • OPN1LW Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064445.1  
    ENSEMBL proteins: 
     ENSP00000358967   ENSP00000402493  
    Reactome Protein details: P04000
    Human Recombinant Protein Products: 
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    Uscn Proteins for OPN1LW

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9860863
    GO:0016021integral to membrane ----


    OPN1LW for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for OPN1LW gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OPN1LW for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001760 Opsin
     IPR000378 Opsin_red/grn
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04000

    ProtoNet protein and cluster: P04000

    2 Blocks protein families:
    IPB000378 Red/green-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Function
    for OPN1LW gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
    covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=560 nm;

    miRNA
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    hsa-miR-3926
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    Inhib. RNA
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    OriGene shRNA RFP: OPN1LW
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0009881photoreceptor activity IEA--


    OPN1LW for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for OPN1LW:
     Increased circadian period len  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for OPN1LW gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Defective OPN1LW causes CBP
    		Defective OPN1MW causes COD50.50
    		The retinoid cycle in cones (daylight vision)0.50
    		Defective OPN1SW causes tritanopia0.50
    		Retinoid cycle disease events0.33
    		Defective OPN1MW causes DCB and BCM0.50
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Retinoid metabolism and transport
    		Visual phototransduction0.74
    		Diseases associated with visual transduction0.73
    5Opsins
    		Opsins1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for OPN1LW 
        GPCRs, Class A Rhodopsin-like

    5/15        Reactome Pathways for OPN1LW (see all 15)
        Diseases associated with visual transduction
    GPCR downstream signaling
    The retinoid cycle in cones (daylight vision)
    Retinoid cycle disease events
    Defective OPN1MW causes DCB and BCM



    OPN1LW for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPN1LW

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for OPN1LW (P040003 ENSP000003589674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP2P497923, ENSP000002831954I2D: score=2 STRING: ENSP00000283195
    NCOA2Q155963, ENSP000003999684I2D: score=1 STRING: ENSP00000399968
    PIAS3Q9Y6X23, ENSP000003767654I2D: score=1 STRING: ENSP00000376765
    TICAM2Q86XR73, ENSP000003863414I2D: score=1 STRING: ENSP00000386341
    TMED7Q9Y3B33I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS2937147
    GO:0007601visual perception IEA--
    GO:0007602phototransduction IEA--
    GO:0018298protein-chromophore linkage IEA--


    OPN1LW for ontologies           About GeneDecksing



    Drugs & Compounds
    for OPN1LW gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OPN1LW for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OPN1LW
    2 Novoseek chemical compound relationships for OPN1LW gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choline 35.6 2 15895092 (2)
    calcium 0 2 2029536 (1), 11574661 (1)

    Search CenterWatch for drugs/clinical trials and news about OPN1LW / OPSR 

    Transcripts
    for OPN1LW gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OPN1LW gene: 
    NM_020061.4  

    Unigene Cluster for OPN1LW:

    Opsin 1 (cone pigments), long-wave-sensitive
    Hs.592247  [show with all ESTs]
    Unigene Representative Sequence: CR749814
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369951(uc004fjz.4) ENST00000463296 ENST00000442922

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate OPN1LW:
    hsa-miR-3926
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    Inhib. RNA
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    OriGene shRNA RFP: OPN1LW
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    Clone
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    Primer
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    Additional cDNA sequence: CR749814.1 

    1 DOTS entry:

    DT.436489 

    24/28 AceView cDNA sequences (see all 28):

    NM_020061 BQ637240 BV183302 BV181234 BV183299 BV181076 BV167405 BV182703 
    BQ638605 BV167401 BV167404 BV181233 BQ639996 BV167402 AW950066 T27896 
    CR749814 BQ638223 BV183301 BV183300 BV167403 BV183303 BM704021 BV182704 

    GeneLoc Exon Structure


    Expression
    for OPN1LW gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OPN1LW expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OPN1LW expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature L Cone CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Photoreceptor-like cells (Differentiation of h...)
    Photoreceptor-like cells (Generation of retina...)Eye

    See OPN1LW Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OPN1LW

    SOURCE GeneReport for Unigene cluster: Hs.592247

    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

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    In Situ
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    Orthologs
    for OPN1LW gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OPN1LW gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OPN1LW1 opsin 1 (cone pigments), long-wave-sensitive (color more 77.68(n)
    85.71(a)    		   396421  NM_205440.1  NP_990771.1 
    lizard
    (Anolis carolinensis)    		 Reptilia OPSR_ANOCA6
    --
    (see all 4)    		 --
    		 82(a)
    53(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 2(88664911-88668635)
    AAWZ02040148(1849-6661)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.318702 Xenopus laevis red-sensitive cone opsin mRNA, complete more 77.55(n)    U90895.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii opn1lw12 opsin 1 (cone pigments), long-wave-sensitive, 1 77.83(n)   30413  AF109371.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 Pteropsin
    		 23(a)
    		 1 → many
    		 Group9.2(283911-292747)


    ENSEMBL Gene Tree for OPN1LW (if available)
    TreeFam Gene Tree for OPN1LW (if available) 

    Paralogs
    for OPN1LW gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OPN1LW gene
    OPN32  OPN1MW2  OPN1SW2  RHO2  RGR2  OPN42  OPN1MW22  RRH2  
    OPN52  
    7 SIMAP similar genes for OPN1LW using alignment to 2 protein entries:     OPSR_HUMAN (see all proteins):
    DKFZp781I1948    OPN1MW    OPN1MW2    OPN1SW    RHO    OPN4
    RRH

    OPN1LW for paralogs           About GeneDecksing



    Genomic Variants
    for OPN1LW gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 NCBI SNPs in OPN1LW are shown (see all 115)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs9494311,2
    		C,Fnon-pathogenic153418541(+) TCTGGG/TCTGCT 2 A S mis13Minor allele frequency- T:0.38MN NS NA 254
    rs1214346211,2
    		Cpathogenic153420077(+) CTTCAC/TGCGGC 2 R C mis10--------
    rs1048949121,2
    		Cpathogenic153420209(+) CCATCC/TGAGCG 2 R * stg10--------
    rs1048949131,2
    		Cpathogenic153424319(+) TTTCGA/GGAAGA 2 E G mis10--------
    rs1455105461,2
    		--153407928(+) TACGTG/TTAACT 1 -- us2k10--------
    rs123971271,2
    		C,F,H,--153407940(+) TTGGAG/TGAGCT 1 -- us2k18Minor allele frequency- T:0.22NS NA CSA 967
    rs123971281,2
    		C,--153407941(+) tggagA/Gagctg 1 -- us2k10--------
    rs1890815991,2
    		--153408062(+) CTCCCC/GTGTCC 1 -- us2k10--------
    rs1814341611,2
    		--153408307(+) GGGTTA/GCTTCT 1 -- us2k10--------
    rs1874393451,2
    		--153408337(+) ACAGTC/GCTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OPN1LW (153409698 - 153424507 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for OPN1LW
         3 CNVs: 97108 83868 74085
    Human Gene Mutation Database (HGMD): OPN1LW

    Locus Specific Mutation Databases (LSDB): OPN1LW

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for OPN1LW gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OPN1LW for disorders           About GeneDecksing

    OMIM gene information: 300822   
    OMIM disorders: 303900  303700  
    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
  • Defects in OPN1LW are the cause of partial colorblindness protan series (CBP) [MIM:303900]; also known as
    • protanopia
  • Defects in OPN1LW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital
    • stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium
    wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived
    from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity,
    pendular nystagmus, and photophobia. Patients often have myopia

    20/23 diseases for OPN1LW (see all 23):    About MalaCards
    red-green color vision defects    color blindness    colorblindness, protan    cone dystrophy
    emery-dreifuss muscular dystrophy    blue cone monochromacy    blindness    color vision deficiency
    beta thalassemia    muscular dystrophy    fundus dystrophy    retinitis pigmentosa
    nystagmus    osteonecrosis    myopia    hepatitis c
    thalassemia    retinitis    sarcoidosis    retinal disease

    2 diseases from the University of Copenhagen DISEASES database for OPN1LW:
    Blue cone monochromacy     Thyroid hormone resistance syndrome
    GeneTests: OPN1LW
    Red-Green Color Vision Defects

    Human Genome Epidemiology (HuGE) Navigator: OPN1LW (3 documents)

    Export disorders for OPN1LW gene to outside databases

    Publications
    for OPN1LW gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OPN1LW gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with OPN1LW)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. (PubMed id 12051694)1, 2 Ueyama H....Yamade S. (2002)
    3. Genetic heterogeneity among blue-cone monochromats. (PubMed id 8213841)1, 2 Nathans J.... Heckenlively J.R. (1993)
    4. Polymorphism in red photopigment underlies variation in colour matching. (PubMed id 1557123)1, 2 Winderickx J....Deeb S.S. (1992)
    5. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (1986)
    6. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2 Nathans J.... Hogness D.S. (1986)
    7. Signatures of selection and gene conversion associated with human color vision variation. (PubMed id 15252758)1, 9 Verrelli B.C. and Tishkoff S.A. (2004)
    8. Gene conversion between red and defective green opsin gene in blue cone monochromacy. (PubMed id 8666378)2, 9 Reyniers E....Willems P.J. (1995)
    9. Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect. (PubMed id 22732407)1 Ueyama H....Ogita H. (2012)
    10. The effect of cone opsin mutations on retinal structur e and the integrity of the photoreceptor mosaic. (PubMed id 23139274)1 Carroll J....Michaelides M. (2012)

    External Searches for OPN1LW gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OPN1LW gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5956 HGNC: 9936 AceView: OPN1LW Ensembl:ENSG00000102076 euGenes: HUgn5956
    ECgene: OPN1LW H-InvDB: OPN1LW

    Other Databases showing OPN1LW gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OPN1LW gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OPN1LW Pharmacogenomics, SNPs, Pathways
    Mutations of the color pigment geneshttp://www.retina-international.org/files/sci-news/cppmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPN1LW

    Intellectual Property
    for OPN1LW gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OPN1LW gene:
    Search GeneIP for patents involving OPN1LW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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