OPHN1 Gene
protein-coding GIFtS: 59
GCID: GC0XM067262
|
|
oligophrenin 1(Previous names: mental retardation, X-linked 60 )
(Previous symbol: MRX60)
| |
Aliases
for OPHN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oligophrenin 11 2 | | Mental Retardation, X-Linked 601 2 | | MRX601 2 5 | | Oligophrenin-11 | | ARHGAP411 2 | | Oligophrenin-1, Rho-GTPase Activating Protein2 | | OPN11 2 | | |
Export aliases for OPHN1 gene to outside databasesPrevious GC identifers: GC0XM063483 GC0XM064728 GC0XM065495 GC0XM066129 GC0XM067045 GC0XM067178 GC0XM061092 |
Summaries
for OPHN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OPHN1:
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteinsare important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis.Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia anddistinctive facial dysmorhphism. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890Function: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling isimplicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity).Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation ofsynaptic vesicle endocytosis at presynaptic terminals (By similarity)
Gene Wiki entry for OPHN1
|
Genomic Views
for OPHN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OPHN1 gene promoter:
GATA-3 MyoD Lmo2 Nkx2-5 NF-AT GATA-1 GATA-2 NF-AT2 IRF-7A NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OPHN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPHN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq12 Ensembl cytogenetic band: Xq12 HGNC cytogenetic band: Xq12OPHN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM067262: view genomic region
(about GC identifiers)
Start:
|
67,262,186 bp from pter |
End:
|
67,653,755 bp from pter |
Size:
|
391,570 bases |
Orientation:
|
minus strand |
|
Proteins
for OPHN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890 (See
protein sequence)Recommended Name: Oligophrenin-1 Size: 802 amino acids; 91641 Da
Subunit: Interacts with HOMER1. Interacts with AMPA receptor complexes. Interacts with SH3GL2 (endophilin-A1) (Bysimilarity)
Subcellular location: Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Note=Present inboth presynaptic and postsynaptic sites (By similarity)
Secondary accessions: B9EIP8 Q5JQ81 Q8WX47Explore the universe of human proteins at neXtProt for OPHN1: NX_O60890
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60890
OPHN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002538.1
ENSEMBL proteins: ENSP00000347710 ENSP00000438617 Reactome Protein details: O60890
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
OPHN1 for ontologies About GeneDecksing
OPHN1 Antibody Products:
Assay Products for OPHN1: |
Protein
Domains /
Families
for OPHN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OPHN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60890ProtoNet protein and cluster: O60890 2 Blocks protein families: IPB000198 RhoGAP domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890Similarity: Contains 1 PH domainSimilarity: Contains 1 Rho-GAP domain |
Function
for OPHN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890Function: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling isimplicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity).Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation ofsynaptic vesicle endocytosis at presynaptic terminals (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPHN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPHN1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
OPHN1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ophn1tm1Bill for OPHN1
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ophn1):
OPHN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OPHN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Neuroscience | | | 3 | Regulation of RhoA activity | | | 4 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for OPHN1
1  BioSystems Pathway for OPHN1
3 
Reactome Pathways for OPHN1
OPHN1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OPHN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for OPHN1 (O608903 ENSP000003477104) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
OPHN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for OPHN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OPHN1
1 HMDB Compound for OPHN1 About this table
Search CenterWatch for drugs/clinical trials and news about OPHN1
|
Transcripts
for OPHN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OPHN1 gene: NM_002547.2 Unigene Cluster for OPHN1: Oligophrenin 1 Hs.128824 [show with all ESTs]Unigene Representative Sequence: NM_0025476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355520(uc004dww.4 uc011mpg.2) ENST00000484842 ENST00000467444
ENST00000486068 ENST00000491714 ENST00000540071(uc004dwx.3 uc010nku.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPHN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPHN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OPHN1 (NM_002547) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPHN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPHN1 |
Additional cDNA sequence: AB102656.1 AJ001189.1 AK130340.1 AK295769.1 AK309665.1 AK309696.1 BC059393.1 BC140763.1 8 DOTS entries: DT.115370 DT.202572 DT.100676949 DT.121309966 DT.95143726 DT.95342357 DT.100018949 DT.121309979 24/50 AceView cDNA sequences (see all 50): BX641302 CR605867 AI400949 AW572478 CB266029 CF529728 CB266700 CA390085 BQ011131 BU621294 BP357826 AA532382 AB102656 BP337692 CD358119 BM995047 AW131775 AA706097 AI866744 BQ013636 AW444450 AL697889 AL603381 BP358525
GeneLoc Exon Structure
|
Expression
for OPHN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OPHN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTTTCAA
About this image
See OPHN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OPHN1
SOURCE GeneReport for Unigene cluster: Hs.128824
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890Tissue specificity: Expressed in brain
SABiosciences Custom PCR Arrays for OPHN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPHN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPHN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPHN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPHN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPHN1 |
Orthologs
for OPHN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for OPHN1 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
OPHN11 |
oligophrenin 1 |
74.96(n)
83.29(a) |
|
422162 XM_420161.3 XP_420161.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
57(a) |
1 ↔ 1 |
GL343465.1(375298-384749) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC688562 |
hypothetical protein MGC68856 |
75.18(n) |
|
BC059290.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ophn16 |
oligophrenin 1 |
63(a) |
1 ↔ 1 |
5(37300581-37361639) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Graf3 |
RAL interactor |
38(a) |
|
13E14 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T04C9.16 |
Protein T04C9.1, isoform c |
27(a) |
1 → many |
III(5993181-6006318) |
ENSEMBL Gene Tree for OPHN1 (if available)
TreeFam Gene Tree for OPHN1 (if available) |
Paralogs
for OPHN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OPHN1 gene
- HMHA12 ARHGAP212 ARHGAP272 ARHGAP102 CHN22 ARHGAP232 ARHGAP92 ARHGAP292
- CHN12 ARHGAP262 ARHGAP152 ARHGAP122 GMIP2 ARHGAP422
17 SIMAP similar genes for OPHN1 using alignment to 4 protein entries: OPHN1_HUMAN (see all proteins):GRAF ARHGAP42 CHN2-3 ARHGAP26 CHN2 ARHGAP27
ARHGAP10 ARHGAP12 CHN1 ARHGAP21 ARHGAP24 ARHGAP31
ARHGAP23 HMHA1 DKFZp667D142 ARHGAP5 ARHGAP9
OPHN1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OPHN1
PGOHUM00000240312 PGOHUM00000240907
|
Genomic Variants
for OPHN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OPHN1 (67262186 - 67512186 bp, first 250kb of OPHN1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for OPHN1
8 CNVs: 53021 9347 22600 53020 53023 3266 103255 53022
Human Gene Mutation Database (HGMD): OPHN1
Locus Specific Mutation Databases (LSDB): OPHN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPHN1 |
|
Disorders
/ Diseases
for OPHN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OPHN1 for disorders About GeneDecksing
OMIM gene information: 300127
OMIM disorders: 300486
UniProtKB/Swiss-Prot: OPHN1_HUMAN, O60890
Defects in OPHN1 are the cause of mental retardation X-linked OPHN1-related (MRXSO) [MIM:300486]; formerlydesignated MRX60. MRXSO is a syndromic mental retardation. Patients present mental retardation associated withcerebellar hypoplasia and distinctive facial dysmorphism
14  diseases for OPHN1: About MalaCardsmental retardation, x-linked cerebellar hypoplasia x-linked mental retardation with epilepsy mental retardation epilepsy
autism spectrum disorder strabismus craniofrontonasal syndrome intellectual disability
spasticity seizures gastric cancer ataxia
cerebritis schizophrenia
1 disease from the University of Copenhagen DISEASES database for OPHN1:Intellectual disability 5 Novoseek disease relationships for OPHN1 gene About this table
Genetic Association Database (GAD): OPHN1
Human Genome Epidemiology (HuGE) Navigator: OPHN1 (3 documents)
Export disorders for OPHN1 gene to outside databases
|
Publications
for OPHN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OPHN1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with OPHN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (PubMed id 9582072)1, 2, 3, 9 Billuart P....Chelly J. (1998)
- Determination of the gene structure of human oligophrenin-1 and identification of three novel polymorphisms by screening of DNA from 164 patients with non-specific X-linked mental retardation. (PubMed id 10818214)1, 2, 9 Billuart P.... Bienvenu T. (2000)
- Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia. (PubMed id 16221952)1, 4, 9 Zanni G....Chelly J. (2005)
- Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia. (PubMed id 10439959)1, 2, 9 Tentler D.... Dahl N. (1999)
- Insertion of 16 amino acids in the BAR domain of the oligophrenin 1 protein causes mental retardation and cerebellar hypoplasia in an Italian family. (PubMed id 21796728)1, 2 Pirozzi F.... Chiurazzi P. (2011)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. (PubMed id 12777533)1, 2 Kitano T.... Paeaebo S. (2003)
- Mapping of the X-breakpoint involved in a balanced X;12 translocation in a female with mild mental retardation. (PubMed id 9195162)1, 3 Bienvenu T....Cherif D. (1997)
- Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia. (PubMed id 12805098)1, 9 Bergmann C....Ramaekers V.T. (2003)
- Evidence that a major site of expression of the RHO-GTPASE activating protein, oligophrenin-1, is peripheral myelin. (PubMed id 15026118)1, 9 Xiao J....Furness J.B. (2004)
|
External Searches for OPHN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OPHN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OPHN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OPHN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OPHN1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPHN1 |
|
| | |
About This Section
| Patent Information for OPHN1 gene:
Search GeneIP for patents involving OPHN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OPHN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OPHN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPHN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPHN1 | | | OriGene Protein Over-expression Lysate for OPHN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OPHN1 | | OriGene 3'-UTR Clone for OPHN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPHN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPHN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OPHN1 | | OriGene Custom Protein Services for OPHN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OPHN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPHN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPHN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPHN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPHN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPHN1 |
| |
 |  |  |  | |
| | Antibodies & Assays for OPHN1 |
| | | | Search Tocris compounds for OPHN1 |
| |  |  |  |  | | | | |
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 | | | OPHN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPHN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for OPHN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPHN1 |
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