Aliases for OPCML Gene
External Ids for OPCML Gene
Previous GeneCards Identifiers for OPCML Gene
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for OPCML Gene
OPCML (Opioid Binding Protein/Cell Adhesion Molecule-Like) is a Protein Coding gene. Diseases associated with OPCML include ovarian cancer, somatic and juvenile pilocytic astrocytoma. GO annotations related to this gene include opioid receptor activity. An important paralog of this gene is NTM.
UniProtKB/Swiss-Prot for OPCML Gene
Binds opioids in the presence of acidic lipids; probably involved in cell contact