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Aliases for OPCML Gene

Aliases for OPCML Gene

  • Opioid Binding Protein/Cell Adhesion Molecule Like 2 3 5
  • IgLON Family Member 1 2 3 4
  • IGLON1 3 4
  • OBCAM 3 4
  • Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein 3
  • Opioid-Binding Protein/Cell Adhesion Molecule 3
  • Opioid-Binding Cell Adhesion Molecule 4
  • OPCM 3

External Ids for OPCML Gene

Previous GeneCards Identifiers for OPCML Gene

  • GC11M134422
  • GC11M133802
  • GC11M132321
  • GC11M131825
  • GC11M131790
  • GC11M128240

Summaries for OPCML Gene

Entrez Gene Summary for OPCML Gene

  • This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for OPCML Gene

OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) is a Protein Coding gene. Diseases associated with OPCML include Ovarian Cancer, Somatic and Juvenile Pilocytic Astrocytoma. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include opioid receptor activity. An important paralog of this gene is NTM.

UniProtKB/Swiss-Prot for OPCML Gene

  • Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Gene Wiki entry for OPCML Gene

Additional gene information for OPCML Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPCML Gene

Genomics for OPCML Gene

Regulatory Elements for OPCML Gene

Enhancers for OPCML Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H132894 0.5 FANTOM5 7.7 +638.0 637960 0.4 HNF4G HNF4A RAD21 OPCML GC11P132899 OPCML-IT2
GH11H133559 0.3 FANTOM5 12 -27.2 -27244 0 OPCML GC11M133569
GH11H132904 0.3 FANTOM5 8 +628.0 627951 0.4 OPCML GC11P132899 GC11P132942
GH11H133510 0.2 ENCODE 11.7 +22.2 22242 0 OPCML GC11P133477
GH11H133511 0.2 ENCODE 11.7 +21.9 21878 0.5 OPCML GC11P133477
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OPCML on UCSC Golden Path with GeneCards custom track

Genomic Locations for OPCML Gene

Genomic Locations for OPCML Gene
1,117,543 bases
Minus strand

Genomic View for OPCML Gene

Genes around OPCML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPCML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPCML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPCML Gene

Proteins for OPCML Gene

  • Protein details for OPCML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Opioid-binding protein/cell adhesion molecule
    Protein Accession:
    Secondary Accessions:
    • B2CZX2
    • B7ZLQ1
    • Q17RN7
    • Q7Z3W6

    Protein attributes for OPCML Gene

    345 amino acids
    Molecular mass:
    38008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPCML Gene


neXtProt entry for OPCML Gene

Post-translational modifications for OPCML Gene

  • Glycosylation at Asn44, Asn70, posLast=140140, Asn285, posLast=293293, and Asn306
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPCML Gene

Domains & Families for OPCML Gene

Gene Families for OPCML Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with OPCML: view

Function for OPCML Gene

Molecular function for OPCML Gene

GENATLAS Biochemistry:
opioid binding cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Phenotypes From GWAS Catalog for OPCML Gene

Phenotypes for OPCML Gene

genes like me logo Genes that share phenotypes with OPCML: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPCML Gene

Localization for OPCML Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPCML Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPCML gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for OPCML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OPCML: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPCML Gene

Pathways & Interactions for OPCML Gene

genes like me logo Genes that share pathways with OPCML: view

Gene Ontology (GO) - Biological Process for OPCML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007155 cell adhesion IEA,TAS --
GO:0008038 neuron recognition TAS 7891157
genes like me logo Genes that share ontologies with OPCML: view

No data available for SIGNOR curated interactions for OPCML Gene

Drugs & Compounds for OPCML Gene

No Compound Related Data Available

Transcripts for OPCML Gene

Unigene Clusters for OPCML Gene

Opioid binding protein/cell adhesion molecule-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPCML Gene

No ASD Table

Relevant External Links for OPCML Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPCML Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OPCML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPCML Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.1), Brain - Frontal Cortex (BA9) (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Cerebellum (x6.4), and Brain - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for OPCML Gene

This gene is overexpressed in Cerebrospinal fluid (33.1), Frontal cortex (22.4), and Fetal Brain (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPCML Gene

Protein tissue co-expression partners for OPCML Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OPCML Gene:


SOURCE GeneReport for Unigene cluster for OPCML Gene:


Evidence on tissue expression from TISSUES for OPCML Gene

  • Nervous system(4.9)
  • Kidney(4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with OPCML: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPCML Gene

Orthologs for OPCML Gene

This gene was present in the common ancestor of animals.

Orthologs for OPCML Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OPCML 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia OPCML 33 34
  • 93.33 (n)
(Rattus norvegicus)
Mammalia Opcml 33
  • 92.66 (n)
(Ornithorhynchus anatinus)
Mammalia OPCML 34
  • 92 (a)
(Bos Taurus)
Mammalia OPCML 33 34
  • 90.63 (n)
(Mus musculus)
Mammalia Opcml 33 16 34
  • 89.02 (n)
(Monodelphis domestica)
Mammalia OPCML 34
  • 88 (a)
(Gallus gallus)
Aves OPCML 33 34
  • 79.46 (n)
(Anolis carolinensis)
Reptilia OPCML 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia opcml 33
  • 74.25 (n)
(Danio rerio)
Actinopterygii opcml 33 34
  • 62.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010222 33
  • 46.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31646 33 34
  • 46.27 (n)
Ama 34
  • 23 (a)
CG11320 34
  • 23 (a)
Lac 34
  • 23 (a)
CG14010 34
  • 21 (a)
CG14521 34
  • 21 (a)
CG40378 34
  • 21 (a)
CG42368 34
  • 20 (a)
CG34391 34
  • 18 (a)
CG31708 34
  • 17 (a)
CG42343 34
  • 17 (a)
CG7166 34
  • 17 (a)
CG32791 34
  • 16 (a)
CG31814 34
  • 15 (a)
CG34353 34
  • 15 (a)
klg 34
  • 14 (a)
wrapper 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea rig-5 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for OPCML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OPCML Gene

Gene Tree for OPCML (if available)
Gene Tree for OPCML (if available)

Paralogs for OPCML Gene

Paralogs for OPCML Gene

(8) SIMAP similar genes for OPCML Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OPCML: view

Variants for OPCML Gene

Sequence variations from dbSNP and Humsavar for OPCML Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137852691 Pathogenic, Ovarian cancer (OC) [MIM:167000] 132,657,203(-) TACAC(C/G)AACCC reference, missense, utr-variant-5-prime
rs1000000250 -- 132,836,394(+) ACTTC(C/T)GTCCC intron-variant
rs1000003867 -- 132,739,010(+) CCCAG(C/T)ACGTT intron-variant
rs1000007331 -- 133,208,378(+) TAGAA(A/G)GGGCC intron-variant
rs1000014239 -- 132,919,353(+) CCACC(C/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPCML Gene

Variant ID Type Subtype PubMed ID
nsv826139 CNV loss 20364138
nsv826138 CNV loss 20364138
nsv818873 CNV loss 17921354
nsv557 CNV deletion 18451855
nsv556594 CNV loss 21841781
nsv556593 CNV gain 21841781
nsv556592 CNV loss 21841781
nsv556589 CNV loss 21841781
nsv525431 CNV loss 19592680
nsv522776 CNV loss 19592680
nsv521504 CNV loss 19592680
nsv518815 CNV gain 19592680
nsv517552 CNV loss 19592680
nsv517407 CNV loss 19592680
nsv513344 CNV insertion 21212237
nsv513343 CNV insertion 21212237
nsv513342 CNV insertion 21212237
nsv511010 OTHER complex 20534489
nsv510282 OTHER sequence alteration 20534489
nsv508662 CNV deletion 20534489
nsv478844 CNV novel sequence insertion 20440878
nsv477518 CNV novel sequence insertion 20440878
nsv39130 CNV insertion 16902084
nsv1153685 CNV duplication 26484159
nsv1145576 CNV deletion 24896259
nsv1136142 CNV deletion 24896259
nsv1130514 CNV deletion 24896259
nsv1129529 CNV tandem duplication 24896259
nsv1127240 CNV deletion 24896259
nsv1120613 CNV deletion 24896259
nsv1116688 CNV tandem duplication 24896259
nsv1113450 CNV deletion 24896259
nsv1112613 CNV deletion 24896259
nsv1070076 CNV deletion 25765185
nsv1054110 CNV loss 25217958
nsv1049431 CNV loss 25217958
nsv1042784 CNV loss 25217958
nsv1037943 CNV gain 25217958
esv990417 CNV deletion 20482838
esv4290 CNV loss 18987735
esv3628149 CNV loss 21293372
esv3628148 CNV loss 21293372
esv3628147 CNV loss 21293372
esv3628143 CNV loss 21293372
esv3628142 CNV loss 21293372
esv3628141 CNV loss 21293372
esv3628140 CNV gain 21293372
esv3628139 CNV gain 21293372
esv3628138 CNV gain 21293372
esv3628135 CNV gain 21293372
esv3628134 CNV gain 21293372
esv3628133 CNV loss 21293372
esv3628131 CNV loss 21293372
esv3628129 CNV loss 21293372
esv3628128 CNV loss 21293372
esv3628127 CNV loss 21293372
esv3628125 CNV loss 21293372
esv3580161 CNV gain 25503493
esv3579991 CNV loss 25503493
esv3579990 CNV loss 25503493
esv3579987 CNV loss 25503493
esv3579986 CNV loss 25503493
esv3579985 CNV loss 25503493
esv3579984 CNV loss 25503493
esv3579981 CNV loss 25503493
esv3548550 CNV deletion 23714750
esv3548549 CNV deletion 23714750
esv3548544 CNV deletion 23714750
esv3427501 CNV insertion 20981092
esv3426898 CNV insertion 20981092
esv3395897 CNV duplication 20981092
esv3389792 CNV duplication 20981092
esv3310547 CNV novel sequence insertion 20981092
esv3020 CNV loss 18987735
esv2762952 CNV loss 21179565
esv2760510 CNV loss 21179565
esv2745305 CNV deletion 23290073
esv2745304 CNV deletion 23290073
esv2745303 CNV deletion 23290073
esv2745302 CNV deletion 23290073
esv2745301 CNV deletion 23290073
esv2745300 CNV deletion 23290073
esv2745298 CNV deletion 23290073
esv2745295 CNV deletion 23290073
esv2745294 CNV deletion 23290073
esv2745293 CNV deletion 23290073
esv2745292 CNV deletion 23290073
esv2745291 CNV deletion 23290073
esv2745290 CNV deletion 23290073
esv2745289 CNV deletion 23290073
esv2745288 CNV deletion 23290073
esv2745287 CNV deletion 23290073
esv2745285 CNV deletion 23290073
esv2677127 CNV deletion 23128226
esv2672311 CNV deletion 23128226
esv2670789 CNV deletion 23128226
esv2666465 CNV deletion 23128226
esv2661740 CNV deletion 23128226
esv2657693 CNV deletion 23128226
esv2657031 CNV deletion 23128226
esv2582756 CNV insertion 19546169
esv2483165 CNV deletion 19546169
esv2471562 CNV insertion 19546169
esv2421631 CNV deletion 20811451
esv2337795 CNV deletion 18987734
esv2323872 CNV deletion 18987734
esv2195896 CNV deletion 18987734
esv2153700 CNV deletion 18987734
esv1528909 CNV insertion 17803354
esv1321885 CNV insertion 17803354
esv1173177 CNV insertion 17803354
esv1134786 CNV deletion 17803354
esv1010253 CNV deletion 20482838
esv1007109 CNV insertion 20482838
dgv85n21 CNV loss 19592680
dgv741n106 CNV deletion 24896259
dgv740n106 CNV deletion 24896259
dgv54e55 CNV gain 17911159
dgv426e212 CNV loss 25503493
dgv425e212 CNV loss 25503493
dgv237e214 CNV loss 21293372
dgv2203n54 CNV gain 21841781
dgv158e201 CNV deletion 23290073
dgv1300n100 CNV gain 25217958

Variation tolerance for OPCML Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPCML Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPCML Gene

Disorders for OPCML Gene

MalaCards: The human disease database

(2) MalaCards diseases for OPCML Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
ovarian cancer, somatic
  • adenocarcinoma, ovarian, somatic
juvenile pilocytic astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search OPCML in MalaCards View complete list of genes associated with diseases


  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269 PubMed:12819783}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for OPCML

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OPCML: view

No data available for Genatlas for OPCML Gene

Publications for OPCML Gene

  1. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. (PMID: 12819783) Sellar GC … Gabra H (Nature genetics 2003) 3 4 22 60
  2. Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). (PMID: 7721093) Shark KB … Lee NM (Gene 1995) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Genome-wide association of sleep and circadian phenotypes. (PMID: 17903308) Gottlieb DJ … Wilk JB (BMC medical genetics 2007) 3 45 60

Products for OPCML Gene

Sources for OPCML Gene

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