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Aliases for OPCML Gene

Aliases for OPCML Gene

  • Opioid Binding Protein/Cell Adhesion Molecule-Like 2 3 5
  • IgLON Family Member 1 2 3 4
  • IGLON1 3 4
  • OBCAM 3 4
  • Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein 3
  • Opioid-Binding Protein/Cell Adhesion Molecule-Like 2
  • Opioid-Binding Cell Adhesion Molecule 4
  • OPCM 3

External Ids for OPCML Gene

Previous GeneCards Identifiers for OPCML Gene

  • GC11M134422
  • GC11M133802
  • GC11M132321
  • GC11M131825
  • GC11M131790
  • GC11M128240

Summaries for OPCML Gene

Entrez Gene Summary for OPCML Gene

  • This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for OPCML Gene

OPCML (Opioid Binding Protein/Cell Adhesion Molecule-Like) is a Protein Coding gene. Diseases associated with OPCML include Ovarian Cancer, Somatic and Ovarian Cancer. GO annotations related to this gene include opioid receptor activity. An important paralog of this gene is LSAMP.

UniProtKB/Swiss-Prot for OPCML Gene

  • Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Gene Wiki entry for OPCML Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPCML Gene

Genomics for OPCML Gene

Regulatory Elements for OPCML Gene

Enhancers for OPCML Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OPCML on UCSC Golden Path with GeneCards custom track

Genomic Location for OPCML Gene

132,414,977 bp from pter
133,532,519 bp from pter
1,117,543 bases
Minus strand

Genomic View for OPCML Gene

Genes around OPCML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPCML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPCML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPCML Gene

Proteins for OPCML Gene

  • Protein details for OPCML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Opioid-binding protein/cell adhesion molecule
    Protein Accession:
    Secondary Accessions:
    • B2CZX2
    • B7ZLQ1
    • Q17RN7
    • Q7Z3W6

    Protein attributes for OPCML Gene

    345 amino acids
    Molecular mass:
    38008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPCML Gene


neXtProt entry for OPCML Gene

Proteomics data for OPCML Gene at MOPED

Post-translational modifications for OPCML Gene

  • Glycosylation at Asn 44, Asn 70, Asn 140, Asn 285, Asn 293, and Asn 306
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for OPCML Gene

Domains & Families for OPCML Gene

Protein Domains for OPCML Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with OPCML: view

Function for OPCML Gene

Molecular function for OPCML Gene

GENATLAS Biochemistry:
opioid binding cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Phenotypes for OPCML Gene

genes like me logo Genes that share phenotypes with OPCML: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OPCML

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPCML Gene

Localization for OPCML Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPCML Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for OPCML Gene COMPARTMENTS Subcellular localization image for OPCML gene
Compartment Confidence
extracellular 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for OPCML Gene

Pathways & Interactions for OPCML Gene

SuperPathways for OPCML Gene

No Data Available

Interacting Proteins for OPCML Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000330862 Q14982-OPCM_HUMAN for OPCML Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OPCML Gene


No data available for Pathways by source and SIGNOR curated interactions for OPCML Gene

Drugs & Compounds for OPCML Gene

No Compound Related Data Available

Transcripts for OPCML Gene

Unigene Clusters for OPCML Gene

Opioid binding protein/cell adhesion molecule-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPCML Gene

No ASD Table

Relevant External Links for OPCML Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPCML Gene

mRNA expression in normal human tissues for OPCML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPCML Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.1), Brain - Frontal Cortex (BA9) (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Cerebellum (x6.4), and Brain - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for OPCML Gene

This gene is overexpressed in Cerebrospinal fluid (33.1), Frontal cortex (22.4), and Fetal Brain (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPCML Gene

SOURCE GeneReport for Unigene cluster for OPCML Gene Hs.4817

genes like me logo Genes that share expression patterns with OPCML: view

Protein tissue co-expression partners for OPCML Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for OPCML Gene

Orthologs for OPCML Gene

This gene was present in the common ancestor of animals.

Orthologs for OPCML Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPCML 35
  • 90.63 (n)
  • 97.68 (a)
  • 89 (a)
(Canis familiaris)
Mammalia OPCML 35
  • 93.33 (n)
  • 97.97 (a)
  • 98 (a)
(Mus musculus)
Mammalia Opcml 35
  • 89.02 (n)
  • 93.77 (a)
Opcml 16
Opcml 36
  • 94 (a)
(Pan troglodytes)
Mammalia OPCML 35
  • 99.81 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Opcml 35
  • 92.66 (n)
  • 98.26 (a)
(Monodelphis domestica)
Mammalia OPCML 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia OPCML 36
  • 92 (a)
(Gallus gallus)
Aves OPCML 35
  • 79.46 (n)
  • 85.17 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia OPCML 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia opcml 35
  • 74.25 (n)
  • 76.32 (a)
(Danio rerio)
Actinopterygii opcml 35
  • 62.56 (n)
  • 61.86 (a)
opcml 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010222 35
  • 46.34 (n)
  • 35.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31646 35
  • 46.27 (n)
  • 35.82 (a)
Ama 36
  • 23 (a)
CG11320 36
  • 23 (a)
CG14010 36
  • 21 (a)
CG14521 36
  • 21 (a)
CG31646 36
  • 17 (a)
CG31708 36
  • 17 (a)
CG31814 36
  • 15 (a)
CG32791 36
  • 16 (a)
CG34353 36
  • 15 (a)
CG34391 36
  • 18 (a)
CG40378 36
  • 21 (a)
CG42343 36
  • 17 (a)
CG42368 36
  • 20 (a)
CG7166 36
  • 17 (a)
klg 36
  • 14 (a)
Lac 36
  • 23 (a)
wrapper 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea rig-5 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for OPCML:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OPCML Gene

Gene Tree for OPCML (if available)
Gene Tree for OPCML (if available)

Paralogs for OPCML Gene

Paralogs for OPCML Gene

(8) SIMAP similar genes for OPCML Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OPCML: view

Variants for OPCML Gene

Sequence variations from dbSNP and Humsavar for OPCML Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_055421 Ovarian cancer (OC)
rs520024 -- 133,174,000(+) CAGGG(A/G)CAGCA intron-variant
rs524165 -- 133,179,666(-) GTCAC(A/G)GTCCC intron-variant
rs524319 -- 133,209,124(+) ATATC(A/G)CTTAA intron-variant
rs525471 -- 132,723,803(-) AATTT(C/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPCML Gene

Variant ID Type Subtype PubMed ID
esv2153700 CNV Deletion 18987734
esv2745285 CNV Deletion 23290073
nsv518815 CNV Gain 19592680
esv2483165 CNV Deletion 19546169
esv2337795 CNV Deletion 18987734
esv3020 CNV Deletion 18987735
esv2745287 CNV Deletion 23290073
esv2661740 CNV Deletion 23128226
nsv511010 CNV Complex 20534489
esv2657031 CNV Deletion 23128226
esv2745288 CNV Deletion 23290073
esv2323872 CNV Deletion 18987734
nsv826138 CNV Loss 20364138
nsv557 CNV Loss 18451855
dgv54e55 CNV Gain 17911159
nsv521504 CNV Loss 19592680
nsv522776 CNV Loss 19592680
esv2745289 CNV Deletion 23290073
esv2745290 CNV Deletion 23290073
esv990417 CNV Deletion 20482838
esv2745291 CNV Deletion 23290073
esv1007109 CNV Insertion 20482838
nsv39130 CNV Insertion 16902084
esv1528909 CNV Insertion 17803354
esv2582756 CNV Insertion 19546169
nsv898471 CNV Gain 21882294
nsv517552 CNV Loss 19592680
esv1321885 CNV Insertion 17803354
nsv513343 CNV Insertion 21212237
esv2677127 CNV Deletion 23128226
nsv510282 CNV Loss 20534489
dgv85n21 CNV Loss 19592680
esv2672311 CNV Deletion 23128226
esv2745292 CNV Deletion 23290073
esv2745293 CNV Deletion 23290073
esv4290 CNV Deletion 18987735
esv2745294 CNV Deletion 23290073
esv2657693 CNV Deletion 23128226
nsv508662 CNV Loss 20534489
esv1010253 CNV Deletion 20482838
nsv826139 CNV Loss 20364138
esv2745295 CNV Deletion 23290073
esv2195896 CNV Deletion 18987734
dgv177e201 CNV Deletion 23290073
esv2745298 CNV Deletion 23290073
esv2745300 CNV Deletion 23290073
esv2745301 CNV Deletion 23290073
esv2745302 CNV Deletion 23290073
esv2670789 CNV Deletion 23128226
esv2471562 CNV Insertion 19546169
nsv513344 CNV Insertion 21212237
nsv525431 CNV Loss 19592680
esv2745303 CNV Deletion 23290073
esv1173177 CNV Insertion 17803354
esv2666465 CNV Deletion 23128226
esv2421631 CNV Deletion 20811451
nsv517407 CNV Loss 19592680
nsv818873 CNV Loss 17921354
esv2745304 CNV Deletion 23290073
esv1134786 CNV Deletion 17803354
esv2745305 CNV Deletion 23290073

Variation tolerance for OPCML Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPCML Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPCML Gene

Disorders for OPCML Gene

MalaCards: The human disease database

(3) MalaCards diseases for OPCML Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer, somatic
  • adenocarcinoma, ovarian, somatic
ovarian cancer
  • malignant ovarian tumor
juvenile pilocytic astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search OPCML in MalaCards View complete list of genes associated with diseases


  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269 PubMed:12819783}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for OPCML

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OPCML: view

No data available for Genatlas for OPCML Gene

Publications for OPCML Gene

  1. Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). (PMID: 7721093) Shark K.B. … Lee N.M. (Gene 1995) 3 4 23 67
  2. RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. (PMID: 16384911) Mei F.C. … Cheng X. (FASEB J. 2006) 3 23
  3. Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer. (PMID: 17159813) Czekierdowski A. … Kotarski J. (Neuro Endocrinol. Lett. 2006) 3 23
  4. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. (PMID: 12819783) Sellar G.C. … Gabra H. (Nat. Genet. 2003) 3 23
  5. A sequence-tagged site map of human chromosome 11. (PMID: 8244387) Smith M.W. … Lin Y. (Genomics 1993) 2 3

Products for OPCML Gene

Sources for OPCML Gene