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Aliases for OPCML Gene

Aliases for OPCML Gene

  • Opioid Binding Protein/Cell Adhesion Molecule-Like 2 3
  • IgLON Family Member 1 2 3 4
  • IGLON1 3 4
  • OBCAM 3 4
  • Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein 3
  • Opioid-Binding Protein/Cell Adhesion Molecule-Like 2
  • Opioid-Binding Protein/Cell Adhesion Molecule 3
  • Opioid-Binding Cell Adhesion Molecule 4
  • OPCM 3

External Ids for OPCML Gene

Summaries for OPCML Gene

Entrez Gene Summary for OPCML Gene

  • This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OPCML Gene

OPCML (Opioid Binding Protein/Cell Adhesion Molecule-Like) is a Protein Coding gene. Diseases associated with OPCML include ovarian cancer, somatic. GO annotations related to this gene include opioid receptor activity. An important paralog of this gene is NTM.

UniProtKB/Swiss-Prot for OPCML Gene

  • Binds opioids in the presence of acidic lipids; probably involved in cell contact

Gene Wiki entry for OPCML Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPCML Gene

Genomics for OPCML Gene

Genomic Location for OPCML Gene

Start:
132,414,977 bp from pter
End:
133,532,519 bp from pter
Size:
1,117,543 bases
Orientation:
Minus strand

Genomic View for OPCML Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPCML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPCML Gene

Regulatory Elements for OPCML Gene

Proteins for OPCML Gene

  • Protein details for OPCML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14982-OPCM_HUMAN
    Recommended name:
    Opioid-binding protein/cell adhesion molecule
    Protein Accession:
    Q14982
    Secondary Accessions:
    • B2CZX2
    • B7ZLQ1
    • Q17RN7
    • Q7Z3W6

    Protein attributes for OPCML Gene

    Size:
    345 amino acids
    Molecular mass:
    38008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPCML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPCML Gene

Proteomics data for OPCML Gene at MOPED

Post-translational modifications for OPCML Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn44, Asn70, Asn140, Asn285, Asn293, and Asn306

Other Protein References for OPCML Gene

No data available for DME Specific Peptides for OPCML Gene

Domains for OPCML Gene

Gene Families for OPCML Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for OPCML Gene

UniProtKB/Swiss-Prot:

OPCM_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q14982
Family:
  • Belongs to the immunoglobulin superfamily. IgLON family.:
    • Q14982
genes like me logo Genes that share domains with OPCML: view

Function for OPCML Gene

Molecular function for OPCML Gene

GENATLAS Biochemistry: opioid binding cell adhesion molecule
UniProtKB/Swiss-Prot Function: Binds opioids in the presence of acidic lipids; probably involved in cell contact

Gene Ontology (GO) - Molecular Function for OPCML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004985 opioid receptor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OPCML: view

Phenotypes for OPCML Gene

MGI mutant phenotypes for OPCML:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OPCML: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OPCML Gene

Localization for OPCML Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPCML Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPCML Gene COMPARTMENTS Subcellular localization image for OPCML gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OPCML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane --
GO:0005911 cell-cell junction IBA --
GO:0009986 cell surface IBA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with OPCML: view

Pathways for OPCML Gene

SuperPathways for OPCML Gene

No Data Available

Interacting Proteins for OPCML Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330862%0d%0a9606.ENSP00000368752%0d%0a9606.ENSP00000347184%0d%0a9606.ENSP00000244769%0d%0a9606.ENSP00000350364%0d%0a9606.ENSP00000375478%0d%0a
Selected Interacting proteins: ENSP00000330862 Q14982-OPCM_HUMAN for OPCML Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OPCML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7721093
GO:0008038 neuron recognition TAS 7891157
GO:0016337 single organismal cell-cell adhesion IBA --
GO:0038003 opioid receptor signaling pathway --
GO:0050767 regulation of neurogenesis IBA --
genes like me logo Genes that share ontologies with OPCML: view

No data available for Pathways by source for OPCML Gene

Transcripts for OPCML Gene

Unigene Clusters for OPCML Gene

Opioid binding protein/cell adhesion molecule-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OPCML Gene

No ASD Table

Relevant External Links for OPCML Gene

GeneLoc Exon Structure for
OPCML
ECgene alternative splicing isoforms for
OPCML

Expression for OPCML Gene

mRNA expression in normal human tissues for OPCML Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPCML Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.1), Brain - Frontal Cortex (BA9) (7.3), Brain - Anterior cingulate cortex (BA24) (6.8), Brain - Cerebellum (6.4), and Brain - Cortex (5.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OPCML Gene

SOURCE GeneReport for Unigene cluster for OPCML Gene Hs.4817

genes like me logo Genes that share expressions with OPCML: view

Orthologs for OPCML Gene

This gene was present in the common ancestor of animals.

Orthologs for OPCML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPCML 36
  • 99.81 (n)
  • 100 (a)
OPCML 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPCML 36
  • 90.63 (n)
  • 97.68 (a)
OPCML 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPCML 36
  • 93.33 (n)
  • 97.97 (a)
OPCML 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Opcml 36
  • 89.02 (n)
  • 93.77 (a)
Opcml 16
Opcml 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPCML 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPCML 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Opcml 36
  • 92.66 (n)
  • 98.26 (a)
chicken
(Gallus gallus)
Aves OPCML 36
  • 79.46 (n)
  • 85.17 (a)
OPCML 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPCML 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia opcml 36
  • 74.25 (n)
  • 76.32 (a)
zebrafish
(Danio rerio)
Actinopterygii opcml 36
  • 62.56 (n)
  • 61.86 (a)
opcml 37
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010222 36
  • 46.34 (n)
  • 35.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ama 37
  • 23 (a)
ManyToMany
CG11320 37
  • 23 (a)
ManyToMany
CG14010 37
  • 21 (a)
ManyToMany
CG14521 37
  • 21 (a)
ManyToMany
CG31646 36
  • 46.27 (n)
  • 35.82 (a)
CG31646 37
  • 17 (a)
ManyToMany
CG31708 37
  • 17 (a)
ManyToMany
CG31814 37
  • 15 (a)
ManyToMany
CG32791 37
  • 16 (a)
ManyToMany
CG34353 37
  • 15 (a)
ManyToMany
CG34391 37
  • 18 (a)
ManyToMany
CG40378 37
  • 21 (a)
ManyToMany
CG42343 37
  • 17 (a)
ManyToMany
CG42368 37
  • 20 (a)
ManyToMany
CG7166 37
  • 17 (a)
ManyToMany
klg 37
  • 14 (a)
ManyToMany
Lac 37
  • 23 (a)
ManyToMany
wrapper 37
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rig-5 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToMany
Species with no ortholog for OPCML:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OPCML Gene

ENSEMBL:
Gene Tree for OPCML (if available)
TreeFam:
Gene Tree for OPCML (if available)

Paralogs for OPCML Gene

Paralogs for OPCML Gene

Selected SIMAP similar genes for OPCML Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OPCML: view

Variants for OPCML Gene

Sequence variations from dbSNP and Humsavar for OPCML Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs246 -- 133,075,651(+) ACTCT(A/G)GGGAG intron-variant
rs3360 -- 132,419,867(-) TGCCA(C/T)ACACA utr-variant-3-prime
rs11625 -- 133,257,896(+) GAACA(C/T)CTTGG intron-variant
rs101259 -- 133,134,341(+) CCACA(G/T)AGAAT intron-variant
rs472551 -- 133,226,363(+) GGGTG(C/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPCML Gene

Variant ID Type Subtype PubMed ID
esv2153700 CNV Deletion 18987734
esv2745285 CNV Deletion 23290073
nsv518815 CNV Gain 19592680
esv2483165 CNV Deletion 19546169
esv2337795 CNV Deletion 18987734
esv3020 CNV Deletion 18987735
esv2745287 CNV Deletion 23290073
esv2661740 CNV Deletion 23128226
nsv511010 CNV Complex 20534489
esv2657031 CNV Deletion 23128226
esv2745288 CNV Deletion 23290073
esv2323872 CNV Deletion 18987734
nsv826138 CNV Loss 20364138
nsv557 CNV Loss 18451855
dgv54e55 CNV Gain 17911159
nsv521504 CNV Loss 19592680
nsv522776 CNV Loss 19592680
esv2745289 CNV Deletion 23290073
esv2745290 CNV Deletion 23290073
esv990417 CNV Deletion 20482838
esv2745291 CNV Deletion 23290073
esv1007109 CNV Insertion 20482838
nsv39130 CNV Insertion 16902084
esv1528909 CNV Insertion 17803354
esv2582756 CNV Insertion 19546169
nsv898471 CNV Gain 21882294
nsv517552 CNV Loss 19592680
esv1321885 CNV Insertion 17803354
nsv513343 CNV Insertion 21212237
esv2677127 CNV Deletion 23128226
nsv510282 CNV Loss 20534489
dgv85n21 CNV Loss 19592680
esv2672311 CNV Deletion 23128226
esv2745292 CNV Deletion 23290073
esv2745293 CNV Deletion 23290073
esv4290 CNV Deletion 18987735
esv2745294 CNV Deletion 23290073
esv2657693 CNV Deletion 23128226
nsv508662 CNV Loss 20534489
esv1010253 CNV Deletion 20482838
nsv826139 CNV Loss 20364138
esv2745295 CNV Deletion 23290073
esv2195896 CNV Deletion 18987734
dgv177e201 CNV Deletion 23290073
esv2745298 CNV Deletion 23290073
esv2745300 CNV Deletion 23290073
esv2745301 CNV Deletion 23290073
esv2745302 CNV Deletion 23290073
esv2670789 CNV Deletion 23128226
esv2471562 CNV Insertion 19546169
nsv513344 CNV Insertion 21212237
nsv525431 CNV Loss 19592680
esv2745303 CNV Deletion 23290073
esv1173177 CNV Insertion 17803354
esv2666465 CNV Deletion 23128226
esv2421631 CNV Deletion 20811451
nsv517407 CNV Loss 19592680
nsv818873 CNV Loss 17921354
esv2745304 CNV Deletion 23290073
esv1134786 CNV Deletion 17803354
esv2745305 CNV Deletion 23290073

Relevant External Links for OPCML Gene

HapMap Linkage Disequilibrium report
OPCML
Human Gene Mutation Database (HGMD)
OPCML

Disorders for OPCML Gene

(1) OMIM Diseases for OPCML Gene (600632)

UniProtKB/Swiss-Prot

OPCM_HUMAN
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269 PubMed:12819783}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) MalaCards Diseases for OPCML Gene

Search for OPCML Gene in MalaCards »

(2) Novoseek inferred disease relationships for OPCML Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 30.4 4
tumors 0 4

Relevant External Links for OPCML

Genetic Association Database (GAD)
OPCML
Human Genome Epidemiology (HuGE) Navigator
OPCML
genes like me logo Genes that share disorders with OPCML: view

Publications for OPCML Gene

  1. Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). (PMID: 7721093) Shark K.B. … Lee N.M. (Gene 1995) 3 4 23
  2. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. (PMID: 12819783) Sellar G.C. … Gabra H. (Nat. Genet. 2003) 3 4 23
  3. Opioid-binding protein/cell adhesion molecule-like (OPCML) gene and promoter methylation status in women with ovarian cancer. (PMID: 17159813) Czekierdowski A. … Kotarski J. (Neuro Endocrinol. Lett. 2006) 3 23
  4. A sequence-tagged site map of human chromosome 11. (PMID: 8244387) Smith M.W. … Lin Y. (Genomics 1993) 2 3
  5. RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. (PMID: 16384911) Mei F.C. … Cheng X. (FASEB J. 2006) 3 23

Products for OPCML Gene

Sources for OPCML Gene

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