OPALIN Gene
protein-coding GIFtS: 45
GCID: GC10M098093
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oligodendrocytic myelin paranodal and inner loop protein(Previous name: transmembrane protein 10 )
(Previous symbol: TMEM10)
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Aliases
for OPALIN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oligodendrocytic Myelin Paranodal And Inner Loop Protein1 2 3 | | TMP101 2 | | Transmembrane Protein 101 2 3 | | Opalin1 | | HTMP101 2 3 | | Transmembrane Protein TMP102 | | TMEM101 2 3 | | |
Export aliases for OPALIN gene to outside databasesPrevious GC identifer: GC10M091730 |
Summaries
for OPALIN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for OPALIN (TMEM10)
|
Genomic Views
for OPALIN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OPALIN gene promoter:
Max1 STAT1 AML1a GCNF STAT1beta CUTL1 STAT1alpha YY1 COMP1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OPALIN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPALIN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q23-q24OPALIN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M098093: view genomic region
(about GC identifiers)
Start:
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98,102,973 bp from pter |
End:
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98,119,092 bp from pter |
Size:
|
16,120 bases |
Orientation:
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minus strand |
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Proteins
for OPALIN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OPALI_HUMAN, Q96PE5 (See
protein sequence)Recommended Name: Opalin Size: 141 amino acids; 15683 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelinparanodal and inner loop membranes, but not that of the PNS (By similarity)
Secondary accessions: A8MYG4 B4DK96 Q5W102Alternative splicing: 3 isoforms: Q96PE5-1 Q96PE5-2 Q96PE5-3 (No experimental confirmation available. Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for OPALIN: NX_Q96PE5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PE5
OPALIN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035191.1 NP_001035192.1 NP_149984.1
ENSEMBL proteins: ENSP00000360214 ENSP00000377449 ENSP00000377448 ENSP00000398025 ENSP00000445125
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
OPALIN for ontologies About GeneDecksing
OPALIN Antibody Products:
Assay Products for OPALIN: |
Protein
Domains /
Families
for OPALIN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OPALIN for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96PE5ProtoNet protein and cluster: Q96PE5 |
Function
for OPALIN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): OPALIN (NM_001040102) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPALIN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPALIN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPALIN |
1 GenomeRNAi human phenotype for OPALIN:
|
Pathways & Interactions
for OPALIN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OPALIN
3 Interacting proteins for OPALIN (Q96PE53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for OPALIN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OPALIN
Search CenterWatch for drugs/clinical trials and news about OPALIN / OPALI
|
Transcripts
for OPALIN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OPALIN gene (3 alternative transcripts): NM_001040102.1 NM_001040103.1 NM_033207.3 Unigene Cluster for OPALIN: Oligodendrocytic myelin paranodal and inner loop protein Hs.12449 [show with all ESTs]Unigene Representative Sequence: NM_0010401035 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371172 ENST00000393871(uc001kmk.3) ENST00000393870 ENST00000419479(uc010qor.2 uc001kmi.3 uc001kmj.3 uc010qos.2 uc009xve.1)
ENST00000536387
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): OPALIN (NM_001040102) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OPALIN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPALIN |
Additional cDNA sequence: AF367761.2 AK289835.1 AK296462.1 AK296562.1 AK309095.1 AK311260.1 AK316090.1 AL834229.1 BC024191.1 BC033737.1 5 DOTS entries: DT.40108176 DT.121253618 DT.100649464 DT.121253610 DT.121253597 24/40 AceView cDNA sequences (see all 40): F11129 BC033737 AL834229 BP348941 F13555 Z42095 BP349325 BX422994 NM_033207 BI548014 AI369730 N63401 BI819563 AF367761 BC024191 BP360708 BI670108 CK023662 BI599828 BI548105 AL120023 BP362253 BX423903 BI596691
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OPALIN (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|
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| SP1: | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OPALIN
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Expression
for OPALIN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OPALIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTATAAA
About this image
See OPALIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OPALIN
SOURCE GeneReport for Unigene cluster: Hs.12449
UniProtKB/Swiss-Prot: OPALI_HUMAN, Q96PE5Tissue specificity: Brain specific
SABiosciences Custom PCR Arrays for OPALIN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPALIN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OPALIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPALIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPALIN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPALIN |
Orthologs
for OPALIN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for OPALIN gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Opalin1 , 5 |
oligodendrocytic myelin paranodal and inner loop protein1, 5 |
78.96(n)1
78.01(a)1 |
|
19 (34.36 cM)5
2261151 NM_153520.11 NP_705740.11
410634205 |
ENSEMBL Gene Tree for OPALIN (if available)
TreeFam Gene Tree for OPALIN (if available) |
Paralogs
for OPALIN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OPALIN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OPALIN (98102973 - 98119092 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OPALIN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPALIN |
|
Disorders
/ Diseases
for OPALIN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OPALIN for disorders About GeneDecksing
5  diseases for OPALIN: About MalaCardstemporal lobe epilepsy spastic paraplegia fucosidosis paraplegia
spasticity
1 disease from the University of Copenhagen DISEASES database for OPALIN:Fucosidosis Export disorders for OPALIN gene to outside databases
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Publications
for OPALIN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OPALIN gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with OPALIN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. (PubMed id 11814680)1, 2, 3 Nobile C.... Michelucci R. (2002)
- An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. (PubMed id 17442045)1, 3 Aruga J....Furuichi T. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. (PubMed id 18490449)1 Yoshikawa F....Furuichi T. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Scanning the human proteome for calmodulin-binding pr oteins. (PubMed id 15840729)1 Shen X....Liu R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
|
External Searches for OPALIN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OPALIN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OPALIN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OPALIN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OPALIN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OPALIN gene:
Search GeneIP for patents involving OPALIN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OPALIN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OPALIN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OPALIN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OPALIN | | | OriGene Protein Over-expression Lysate for OPALIN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OPALIN | | OriGene 3'-UTR Clone for OPALIN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OPALIN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OPALIN | | OriGene Custom Protein Services for OPALIN | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OPALIN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OPALIN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OPALIN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OPALIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OPALIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OPALIN |
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| | | | Search Tocris compounds for OPALIN |
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 | | | OPALIN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OPALIN |
|  |  |  | | | | Search ThermoFisher Antibodies for OPALIN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OPALIN |
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