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Aliases for OPALIN Gene

Aliases for OPALIN Gene

  • Oligodendrocytic Myelin Paranodal And Inner Loop Protein 2 3 4
  • Transmembrane Protein 10 2 3 4
  • TMEM10 3 4
  • HTMP10 3 4
  • Transmembrane Protein TMP10 3
  • Opalin 3
  • TMP10 3

External Ids for OPALIN Gene

Previous HGNC Symbols for OPALIN Gene

  • TMEM10

Previous GeneCards Identifiers for OPALIN Gene

  • GC10M098093
  • GC10M091730

Summaries for OPALIN Gene

GeneCards Summary for OPALIN Gene

OPALIN (Oligodendrocytic Myelin Paranodal And Inner Loop Protein) is a Protein Coding gene. Diseases associated with OPALIN include fucosidosis.

Gene Wiki entry for OPALIN Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPALIN Gene

Genomics for OPALIN Gene

Regulatory Elements for OPALIN Gene

Genomic Location for OPALIN Gene

Start:
96,343,216 bp from pter
End:
96,359,365 bp from pter
Size:
16,150 bases
Orientation:
Minus strand

Genomic View for OPALIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPALIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPALIN Gene

Proteins for OPALIN Gene

  • Protein details for OPALIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE5-OPALI_HUMAN
    Recommended name:
    Opalin
    Protein Accession:
    Q96PE5
    Secondary Accessions:
    • A8MX69
    • A8MYG4
    • B4DK96
    • B4DKH0
    • Q5W102

    Protein attributes for OPALIN Gene

    Size:
    141 amino acids
    Molecular mass:
    15683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPALIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPALIN Gene

Proteomics data for OPALIN Gene at MOPED

Post-translational modifications for OPALIN Gene

  • Glycosylation at Asn6, Asn12, and Thr14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPALIN Gene

Domains for OPALIN Gene

Protein Domains for OPALIN Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OPALIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OPALIN Gene

Function for OPALIN Gene

Phenotypes for OPALIN Gene

GenomeRNAi human phenotypes for OPALIN:
genes like me logo Genes that share phenotypes with OPALIN: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OPALIN Gene

Localization for OPALIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPALIN Gene

Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OPALIN Gene COMPARTMENTS Subcellular localization image for OPALIN gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OPALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPALIN: view

Pathways for OPALIN Gene

SuperPathways for OPALIN Gene

No Data Available

Interacting Proteins for OPALIN Gene

Selected Interacting proteins: Q96PE5-OPALI_HUMAN for OPALIN Gene via I2D

Gene Ontology (GO) - Biological Process for OPALIN Gene

None

No data available for Pathways by source for OPALIN Gene

Transcripts for OPALIN Gene

Unigene Clusters for OPALIN Gene

Oligodendrocytic myelin paranodal and inner loop protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPALIN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPALIN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for OPALIN Gene

GeneLoc Exon Structure for
OPALIN
ECgene alternative splicing isoforms for
OPALIN

Expression for OPALIN Gene

mRNA expression in normal human tissues for OPALIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPALIN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (8.3), Brain - Amygdala (7.6), Brain - Hippocampus (7.3), Brain - Caudate (basal ganglia) (5.6), and Brain - Substantia nigra (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OPALIN Gene

SOURCE GeneReport for Unigene cluster for OPALIN Gene Hs.12449

mRNA Expression by UniProt/SwissProt for OPALIN Gene

Q96PE5-OPALI_HUMAN
Tissue specificity: Brain specific.
genes like me logo Genes that share expressions with OPALIN: view

In Situ Assay Products

Orthologs for OPALIN Gene

This gene was present in the common ancestor of mammals.

Orthologs for OPALIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPALIN 35
  • 99.29 (n)
  • 100 (a)
OPALIN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OPALIN 35
  • 83.45 (n)
  • 80.85 (a)
OPALIN 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OPALIN 35
  • 87.23 (n)
  • 85.82 (a)
OPALIN 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Opalin 35
  • 78.96 (n)
  • 78.01 (a)
Opalin 16
Opalin 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPALIN 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Opalin 35
  • 78.01 (n)
  • 78.72 (a)
Species with no ortholog for OPALIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OPALIN Gene

ENSEMBL:
Gene Tree for OPALIN (if available)
TreeFam:
Gene Tree for OPALIN (if available)

Paralogs for OPALIN Gene

No data available for Paralogs for OPALIN Gene

Variants for OPALIN Gene

Sequence variations from dbSNP and Humsavar for OPALIN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1184973 -- 96,355,317(-) TGGGA(A/G/T)CTTTA intron-variant
rs1923702 -- 96,355,927(-) CCACG(A/C)TCTTT intron-variant
rs1951628 -- 96,343,191(-) CCTAT(A/G)TTAGA downstream-variant-500B
rs2146392 -- 96,351,522(-) GTTTA(A/G)CAAAG intron-variant
rs2146393 -- 96,348,601(-) TTAAC(C/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPALIN Gene

Variant ID Type Subtype PubMed ID
nsv831949 CNV Gain 17160897
nsv831950 CNV Gain 17160897

Relevant External Links for OPALIN Gene

HapMap Linkage Disequilibrium report
OPALIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPALIN Gene

Disorders for OPALIN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OPALIN Gene including...

Search for OPALIN Gene in MalaCards »

(1) University of Copenhagen DISEASES for OPALIN Gene

genes like me logo Genes that share disorders with OPALIN: view

No data available for UniProtKB/Swiss-Prot for OPALIN Gene

Publications for OPALIN Gene

  1. Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. (PMID: 11814680) Nobile C. … Michelucci R. (Gene 2002) 2 3 4
  2. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. (PMID: 17442045) Aruga J. … Furuichi T. (J. Neurochem. 2007) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Scanning the human proteome for calmodulin-binding proteins. (PMID: 15840729) Shen X. … Liu R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3

Products for OPALIN Gene

Sources for OPALIN Gene

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