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Aliases for OPALIN Gene

Aliases for OPALIN Gene

  • Oligodendrocytic Myelin Paranodal And Inner Loop Protein 2 3 4
  • Transmembrane Protein 10 2 3 4
  • TMEM10 3 4
  • HTMP10 3 4
  • Transmembrane Protein TMP10 3
  • TMP10 3

External Ids for OPALIN Gene

Previous HGNC Symbols for OPALIN Gene

  • TMEM10

Previous GeneCards Identifiers for OPALIN Gene

  • GC10M098093
  • GC10M091730

Summaries for OPALIN Gene

GeneCards Summary for OPALIN Gene

OPALIN (Oligodendrocytic Myelin Paranodal And Inner Loop Protein) is a Protein Coding gene.

Gene Wiki entry for OPALIN Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPALIN Gene

Genomics for OPALIN Gene

Regulatory Elements for OPALIN Gene

Genomic Location for OPALIN Gene

96,343,216 bp from pter
96,359,365 bp from pter
16,150 bases
Minus strand

Genomic View for OPALIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OPALIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPALIN Gene

Proteins for OPALIN Gene

  • Protein details for OPALIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MX69
    • A8MYG4
    • B4DK96
    • B4DKH0
    • Q5W102

    Protein attributes for OPALIN Gene

    141 amino acids
    Molecular mass:
    15683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPALIN Gene


neXtProt entry for OPALIN Gene

Proteomics data for OPALIN Gene at MOPED

Post-translational modifications for OPALIN Gene

  • Glycosylation at Asn 6, Asn 12, and Thr 14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPALIN Gene

Domains & Families for OPALIN Gene

Protein Domains for OPALIN Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OPALIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OPALIN Gene

Function for OPALIN Gene

Phenotypes for OPALIN Gene

genes like me logo Genes that share phenotypes with OPALIN: view

Animal Model Products

miRNA for OPALIN Gene

miRTarBase miRNAs that target OPALIN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for OPALIN Gene

Localization for OPALIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPALIN Gene

Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for OPALIN Gene COMPARTMENTS Subcellular localization image for OPALIN gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for OPALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0044291 cell-cell contact zone IEA --
genes like me logo Genes that share ontologies with OPALIN: view

Pathways & Interactions for OPALIN Gene

SuperPathways for OPALIN Gene

No Data Available

Interacting Proteins for OPALIN Gene

Selected Interacting proteins: Q96PE5-OPALI_HUMAN for OPALIN Gene via I2D

Gene Ontology (GO) - Biological Process for OPALIN Gene


No data available for Pathways by source and SIGNOR curated interactions for OPALIN Gene

Drugs & Compounds for OPALIN Gene

No Compound Related Data Available

Transcripts for OPALIN Gene

Unigene Clusters for OPALIN Gene

Oligodendrocytic myelin paranodal and inner loop protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OPALIN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPALIN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -

Relevant External Links for OPALIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPALIN Gene

mRNA expression in normal human tissues for OPALIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPALIN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.3), Brain - Amygdala (x7.6), Brain - Hippocampus (x7.3), Brain - Caudate (basal ganglia) (x5.6), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for OPALIN Gene

This gene is overexpressed in Frontal cortex (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OPALIN Gene

SOURCE GeneReport for Unigene cluster for OPALIN Gene Hs.12449

mRNA Expression by UniProt/SwissProt for OPALIN Gene

Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with OPALIN: view

Protein tissue co-expression partners for OPALIN Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for OPALIN Gene

This gene was present in the common ancestor of mammals.

Orthologs for OPALIN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPALIN 35
  • 83.45 (n)
  • 80.85 (a)
  • 75 (a)
(Canis familiaris)
Mammalia OPALIN 35
  • 87.23 (n)
  • 85.82 (a)
  • 79 (a)
(Mus musculus)
Mammalia Opalin 35
  • 78.96 (n)
  • 78.01 (a)
Opalin 16
Opalin 36
  • 77 (a)
(Pan troglodytes)
Mammalia OPALIN 35
  • 99.29 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Opalin 35
  • 78.01 (n)
  • 78.72 (a)
(Monodelphis domestica)
Mammalia OPALIN 36
  • 41 (a)
Species with no ortholog for OPALIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OPALIN Gene

Gene Tree for OPALIN (if available)
Gene Tree for OPALIN (if available)

Paralogs for OPALIN Gene

No data available for Paralogs for OPALIN Gene

Variants for OPALIN Gene

Sequence variations from dbSNP and Humsavar for OPALIN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1184973 -- 96,355,317(-) TGGGA(A/G/T)CTTTA intron-variant
rs1923702 -- 96,355,927(-) CCACG(A/C)TCTTT intron-variant
rs1951628 -- 96,343,191(-) CCTAT(A/G)TTAGA downstream-variant-500B
rs2146392 -- 96,351,522(-) GTTTA(A/G)CAAAG intron-variant
rs2146393 -- 96,348,601(-) TTAAC(C/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OPALIN Gene

Variant ID Type Subtype PubMed ID
nsv831949 CNV Gain 17160897
nsv831950 CNV Gain 17160897

Variation tolerance for OPALIN Gene

Residual Variation Intolerance Score: 82.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OPALIN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPALIN Gene

Disorders for OPALIN Gene

Relevant External Links for OPALIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OPALIN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPALIN Gene

Publications for OPALIN Gene

  1. Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling. (PMID: 18439243) Kippert A. … Simons M. (BMC Neurosci 2008) 23 67
  2. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. (PMID: 17442045) Aruga J. … Furuichi T. (J. Neurochem. 2007) 2 67
  3. Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. (PMID: 11814680) Nobile C. … Michelucci R. (Gene 2002) 2 67
  4. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. (PMID: 18490449) Yoshikawa F. … Furuichi T. (J. Biol. Chem. 2008) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for OPALIN Gene

Sources for OPALIN Gene

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