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OOSP2 Gene

protein-coding   GIFtS: 31
GCID: GC11P059808

Oocyte Secreted Protein 2

(Previous names: transmembrane protein 122, placenta-specific 1-like)
(Previous symbols: TMEM122, PLAC1L)
  Search for OOSP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oocyte Secreted Protein 21 2     Placenta-Specific 1-Like Protein2 3
PLAC1L1 2 3     Placenta-Specific 1-Like1
TMEM1221 2 3     Oocyte-Secreted Protein 22
Transmembrane Protein 1221 2     Protein TMEM1223

External Ids:    HGNC: 266991   Entrez Gene: 2199902   Ensembl: ENSG000001495077   UniProtKB: Q86WS33   

Export aliases for OOSP2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OOSP2 Gene:
OOSP2 (oocyte secreted protein 2) is a protein-coding gene. An important paralog of this gene is PLAC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for OOSP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOOSP2 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OOSP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OOSP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OOSP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059808:  view genomic region     (about GC identifiers)

Start:
59,807,748 bp from pter      End:
59,815,517 bp from pter
Size:
7,770 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OOSP2_HUMAN, Q86WS3 (See protein sequence)
Recommended Name: Oocyte-secreted protein 2 precursor  
Size: 158 amino acids; 17971 Da
Sequence caution: Sequence=AP000790; Type=Erroneous gene model prediction;
Secondary accessions: E9PJA4 Q8N9U6

Explore the universe of human proteins at neXtProt for OOSP2: NX_Q86WS3

Explore proteomics data for OOSP2 at MOPED


See OOSP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_776162.2  
ENSEMBL proteins: 
 ENSP00000278855   ENSP00000433831  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001507 ZP_dom

Graphical View of Domain Structure for InterPro Entry Q86WS3

ProtoNet protein and cluster: Q86WS3

UniProtKB/Swiss-Prot: OOSP2_HUMAN, Q86WS3
Similarity: Belongs to the PLAC1 family


Find genes that share domains with OOSP2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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hsa-mir-335-5p (MIRT017947)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OOSP2_HUMAN, Q86WS3: Secreted (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with OOSP2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OOSP2
Interactions:

    Search GeneGlobe Interaction Network for OOSP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OOSP2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OOSP2 gene: 
NM_173801.3  

Unigene Cluster for OOSP2:

Placenta-specific 1-like
Hs.132310  [show with all ESTs]
Unigene Representative Sequence: NM_173801
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000278855(uc001nol.3) ENST00000527395 ENST00000532905
miRNA
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Additional mRNA sequence: 

AK093517.1 BC036256.1 BC048121.1 

2 DOTS entries:

DT.403588  DT.75171402 

18 AceView cDNA sequences:

BI520154 AI138881 BX118111 BC036256 AK093517 BC048121 BI463012 AI554902 
AI028204 AX748179 NM_173801 AW572898 BG772527 AA608835 BE972717 BI459538 
AW664990 AA383680 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OOSP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OOSP2 Expression
About this image

OOSP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OOSP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.132310
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OOSP2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OOSP2 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Plac1l5
Oosp21
placenta-specific 1-like5
oocyte secreted protein 21
71.24(n)1
55.56(a)1
  19 (8.47 cM)5
2259221  NM_001037634.31  NP_001032723.11 
 116472795 


ENSEMBL Gene Tree for OOSP2 (if available)
TreeFam Gene Tree for OOSP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OOSP2 gene
PLAC12  

Find genes that share paralogs with OOSP2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OOSP2 (see all 257)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2005369491,2
C--59805764(-) CTGAAC/TTAGCC 1 -- us2k10--------
rs1153960291,2
C,F--59805800(+) TTTTCC/TTTGAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1430655411,2
C--59805881(+) AAAAAC/GGCATG 1 -- us2k10--------
rs1474871611,2
--59805895(+) TCAACA/GGTTGG 1 -- us2k10--------
rs1382682241,2
C--59805998(+) ATGGTA/GACTAA 1 -- us2k10--------
rs1821758951,2
--59806095(+) AATGTC/TGACAT 1 -- us2k10--------
rs2015995571,2
C--59806127(+) TTGTG-/AAAATA 1 -- us2k10--------
rs1859135971,2
--59806422(+) AAAATC/TCTGTA 1 -- us2k10--------
rs1438138411,2
--59806598(+) TTGCTA/GTGTCT 1 -- us2k10--------
rs1907827251,2
--59806613(+) CACAAC/TAAGTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OOSP2 (59807748 - 59815517 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OOSP2: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OOSP2
DNA2.0 Custom Variant and Variant Library Synthesis for OOSP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OOSP2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OOSP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 219990 HGNC: 26699 AceView: FLJ36198 Ensembl:ENSG00000149507 euGenes: HUgn219990
ECgene: OOSP2 H-InvDB: OOSP2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OOSP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OOSP2 gene:
Search GeneIP for patents involving OOSP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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