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Aliases for OOSP2 Gene

Aliases for OOSP2 Gene

  • Oocyte Secreted Protein 2 2 3 5
  • Placenta-Specific 1-Like Protein 3 4
  • Transmembrane Protein 122 2 3
  • TMEM122 3 4
  • PLAC1L 3 4
  • Testicular Tissue Protein Li 142 3
  • Oocyte-Secreted Protein 2 3
  • Placenta-Specific 1-Like 2
  • Protein TMEM122 4

External Ids for OOSP2 Gene

Previous HGNC Symbols for OOSP2 Gene

  • TMEM122
  • PLAC1L

Previous GeneCards Identifiers for OOSP2 Gene

  • GC11P059808

Summaries for OOSP2 Gene

GeneCards Summary for OOSP2 Gene

OOSP2 (Oocyte Secreted Protein 2) is a Protein Coding gene. An important paralog of this gene is PLAC1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OOSP2 Gene

Genomics for OOSP2 Gene

Regulatory Elements for OOSP2 Gene

Enhancers for OOSP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G059968 1 FANTOM5 11.2 -72.0 -72004 0.3 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 NCOA1 REST MBD2 OOSP2 MS4A3 MS4A2 MRPL16 OOSP1 LOC105369444
GH11G059919 1 Ensembl ENCODE 10.1 -121.1 -121075 0.4 CTCF ZNF654 CBX3 ZNF384 REST ATF2 RAD21 CHAMP1 RFX5 FOSL1 TCN1 GIF OOSP2 MS4A2 OOSP1 SRD5A3P1
GH11G060251 0.9 Ensembl ENCODE 9.6 +211.7 211715 1.2 CTCF WRNIP1 TRIM22 REST RAD21 CHAMP1 SMC3 ZNF143 ZBTB33 MS4A6E OOSP2 MS4A6A MS4A4A MS4A4E
GH11G060204 0.8 dbSUPER 10.2 +165.5 165508 3.4 PKNOX1 BMI1 GATA2 FOS ETV6 RELB IKZF2 CREM CBFB JUNB TCN1 OOSP2 MS4A6A MS4A4E MS4A4A MIR6503
GH11G060336 1 FANTOM5 ENCODE 4.9 +297.0 297017 1.6 MTA2 BHLHE40 NR2F1 IRF5 BMI1 GATAD2B EBF1 DPF2 TBX21 EP300 MS4A6E MS4A5 MS4A14 MS4A13 OOSP2 GC11P060374
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OOSP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OOSP2 Gene

Chromosome:
11
Start:
60,040,275 bp from pter
End:
60,048,044 bp from pter
Size:
7,770 bases
Orientation:
Plus strand

Genomic View for OOSP2 Gene

Genes around OOSP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OOSP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OOSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OOSP2 Gene

Proteins for OOSP2 Gene

  • Protein details for OOSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WS3-OOSP2_HUMAN
    Recommended name:
    Oocyte-secreted protein 2
    Protein Accession:
    Q86WS3
    Secondary Accessions:
    • E9PJA4
    • Q8N9U6

    Protein attributes for OOSP2 Gene

    Size:
    158 amino acids
    Molecular mass:
    17971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AP000790; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OOSP2 Gene

Post-translational modifications for OOSP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OOSP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OOSP2 Gene

Domains & Families for OOSP2 Gene

Protein Domains for OOSP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OOSP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WS3

UniProtKB/Swiss-Prot:

OOSP2_HUMAN :
  • Belongs to the PLAC1 family.
Family:
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with OOSP2: view

No data available for Gene Families for OOSP2 Gene

Function for OOSP2 Gene

Phenotypes for OOSP2 Gene

genes like me logo Genes that share phenotypes with OOSP2: view

Animal Model Products

miRNA for OOSP2 Gene

miRTarBase miRNAs that target OOSP2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OOSP2 Gene

Localization for OOSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OOSP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OOSP2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OOSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OOSP2: view

Pathways & Interactions for OOSP2 Gene

SuperPathways for OOSP2 Gene

No Data Available

Interacting Proteins for OOSP2 Gene

Selected Interacting proteins: Q86WS3-OOSP2_HUMAN for OOSP2 Gene via IID

Symbol External ID(s) Details
ECT2

Gene Ontology (GO) - Biological Process for OOSP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OOSP2 Gene

Drugs & Compounds for OOSP2 Gene

No Compound Related Data Available

Transcripts for OOSP2 Gene

mRNA/cDNA for OOSP2 Gene

(1) REFSEQ mRNAs :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OOSP2 Gene

No ASD Table

Relevant External Links for OOSP2 Gene

GeneLoc Exon Structure for
OOSP2
ECgene alternative splicing isoforms for
OOSP2

Expression for OOSP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OOSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OOSP2 Gene

This gene is overexpressed in Testis (x52.4).

NURSA nuclear receptor signaling pathways regulating expression of OOSP2 Gene:

OOSP2
genes like me logo Genes that share expression patterns with OOSP2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OOSP2 Gene

Orthologs for OOSP2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OOSP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAC1L 34
  • 99.37 (n)
OOSP2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oosp2 16 34
  • 71.24 (n)
Plac1l 35
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oosp2 34
  • 68.64 (n)
Species where no ortholog for OOSP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OOSP2 Gene

ENSEMBL:
Gene Tree for OOSP2 (if available)
TreeFam:
Gene Tree for OOSP2 (if available)

Paralogs for OOSP2 Gene

Paralogs for OOSP2 Gene

genes like me logo Genes that share paralogs with OOSP2: view

Variants for OOSP2 Gene

Sequence variations from dbSNP and Humsavar for OOSP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000227634 -- 60,041,162(+) TGTTC(-/TTTATGGTTTCTT)TTTGT intron-variant
rs1000294196 -- 60,041,222(+) GAAAC(A/T)GATAC intron-variant
rs1000336891 -- 60,044,880(+) CACCC(A/G)TAAGT intron-variant
rs1000363815 -- 60,047,536(+) GCAGA(G/T)ACTTT utr-variant-3-prime
rs1000414618 -- 60,047,798(+) TTATT(C/T)ATTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OOSP2 Gene

Variant ID Type Subtype PubMed ID
nsv336 CNV insertion 18451855
nsv468579 CNV gain 19166990
nsv509411 CNV insertion 20534489
nsv555150 CNV gain 21841781
nsv832173 CNV gain 17160897

Variation tolerance for OOSP2 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OOSP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OOSP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OOSP2 Gene

Disorders for OOSP2 Gene

Relevant External Links for OOSP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OOSP2

No disorders were found for OOSP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OOSP2 Gene

Publications for OOSP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OOSP2 Gene

Sources for OOSP2 Gene

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