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Aliases for OOEP Gene

Aliases for OOEP Gene

  • Oocyte Expressed Protein 2 3 5
  • KH Homology Domain-Containing Protein 2 3 4
  • Oocyte Expressed Protein Homolog (Dog) 2 3
  • Oocyte- And Embryo-Specific Protein 19 3 4
  • KH Homology Domain Containing 2 2 3
  • C6orf156 3 4
  • HOEP19 3 4
  • KHDC2 3 4
  • Chromosome 6 Open Reading Frame 156 2
  • Oocyte-Expressed Protein Homolog 3
  • Oocyte And Embryo Protein 19 3
  • FLOPED 3
  • OEP19 4

External Ids for OOEP Gene

Previous HGNC Symbols for OOEP Gene

  • C6orf156

Previous GeneCards Identifiers for OOEP Gene

  • GC06M074137
  • GC06M074079
  • GC06M071276

Summaries for OOEP Gene

GeneCards Summary for OOEP Gene

OOEP (Oocyte Expressed Protein) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is KHDC3L.

UniProtKB/Swiss-Prot for OOEP Gene

  • As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OOEP Gene

Genomics for OOEP Gene

Regulatory Elements for OOEP Gene

Enhancers for OOEP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F073460 0.2 ENCODE 11.9 -66.7 -66702 2.5 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 SLC17A5 EIF3EP1 KHDC1 DDX43 OOEP RPL39P3 MTO1 RNU6-975P
GH06F073421 1 Ensembl ENCODE 11.8 -27.3 -27305 2.0 TBP HDAC1 PKNOX1 CBX3 ATF1 CREM ZBTB11 CREB3 SMARCA4 HMBOX1 DDX43 OOEP RPS6P8 RPL39P3 OOEP-AS1 MB21D1
GH06F073513 0.4 ENCODE 11.8 -124.0 -123996 11.3 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZFP41 EIF3EP1 OOEP-AS1 SLC17A5 MTO1 DDX43 OOEP KHDC1P1 KCNQ5-AS1 GC06M073517 GC06M073519
GH06F073967 0.6 ENCODE 11.7 -573.6 -573619 2.1 ZFP64 ZNF140 ZNF101 ZNF316 ZNF202 ZNF654 ZNF680 ZBTB11 REST ZBTB8A KHDC1 DDX43 OOEP EIF3EP1 ENSG00000279790 GC06M073893
GH06F073394 0.2 ENCODE 11.1 +0.3 329 1.3 ZNF687 PKNOX1 CHD1 SIN3A MAX MNT POLR2A ZBTB33 MYC OOEP DDX43
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OOEP on UCSC Golden Path with GeneCards custom track

Promoters for OOEP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001882118 132 799 ZNF687 PKNOX1 CHD1 SIN3A MAX MNT POLR2A ZBTB33 MYC

Genomic Location for OOEP Gene

Chromosome:
6
Start:
73,368,555 bp from pter
End:
73,395,133 bp from pter
Size:
26,579 bases
Orientation:
Minus strand

Genomic View for OOEP Gene

Genes around OOEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OOEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OOEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OOEP Gene

Proteins for OOEP Gene

  • Protein details for OOEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGQ2-OOEP_HUMAN
    Recommended name:
    Oocyte-expressed protein homolog
    Protein Accession:
    A6NGQ2
    Secondary Accessions:
    • A6NIN5
    • A9UIB7

    Protein attributes for OOEP Gene

    Size:
    149 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    • Component of the SCMC which also includes at least KHDC3L, NLRP5 and TLE6.

neXtProt entry for OOEP Gene

Post-translational modifications for OOEP Gene

No Post-translational modifications

Other Protein References for OOEP Gene

No data available for DME Specific Peptides for OOEP Gene

Domains & Families for OOEP Gene

Protein Domains for OOEP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OOEP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGQ2

UniProtKB/Swiss-Prot:

OOEP_HUMAN :
  • Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
  • Belongs to the KHDC1 family.
Domain:
  • Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
  • Contains 1 KH domain.
Family:
  • Belongs to the KHDC1 family.
genes like me logo Genes that share domains with OOEP: view

No data available for Gene Families for OOEP Gene

Function for OOEP Gene

Molecular function for OOEP Gene

UniProtKB/Swiss-Prot Function:
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Gene Ontology (GO) - Molecular Function for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with OOEP: view

Phenotypes for OOEP Gene

genes like me logo Genes that share phenotypes with OOEP: view

Animal Models for OOEP Gene

MGI Knock Outs for OOEP:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OOEP Gene

Localization for OOEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OOEP Gene

Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OOEP Gene COMPARTMENTS Subcellular localization image for OOEP gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005938 cell cortex IEA --
GO:0043234 protein complex IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with OOEP: view

Pathways & Interactions for OOEP Gene

SuperPathways for OOEP Gene

No Data Available

Interacting Proteins for OOEP Gene

Gene Ontology (GO) - Biological Process for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007566 embryo implantation IEA --
GO:0009566 fertilization IEA --
GO:0009880 embryonic pattern specification IEA --
genes like me logo Genes that share ontologies with OOEP: view

No data available for Pathways by source and SIGNOR curated interactions for OOEP Gene

Transcripts for OOEP Gene

mRNA/cDNA for OOEP Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OOEP Gene

Oocyte expressed protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OOEP Gene

No ASD Table

Relevant External Links for OOEP Gene

GeneLoc Exon Structure for
OOEP
ECgene alternative splicing isoforms for
OOEP

Expression for OOEP Gene

mRNA expression in normal human tissues for OOEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OOEP Gene

This gene is overexpressed in Testis (x31.3).

NURSA nuclear receptor signaling pathways regulating expression of OOEP Gene:

OOEP

SOURCE GeneReport for Unigene cluster for OOEP Gene:

Hs.671212
genes like me logo Genes that share expression patterns with OOEP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OOEP Gene

Orthologs for OOEP Gene

This gene was present in the common ancestor of mammals.

Orthologs for OOEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OOEP 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia OOEP 34 35
  • 78.75 (n)
cow
(Bos Taurus)
Mammalia OOEP 34 35
  • 77.38 (n)
mouse
(Mus musculus)
Mammalia Ooep 34 16 35
  • 68.21 (n)
Species where no ortholog for OOEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OOEP Gene

ENSEMBL:
Gene Tree for OOEP (if available)
TreeFam:
Gene Tree for OOEP (if available)

Paralogs for OOEP Gene

Paralogs for OOEP Gene

(2) SIMAP similar genes for OOEP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OOEP Gene

genes like me logo Genes that share paralogs with OOEP: view

Variants for OOEP Gene

Sequence variations from dbSNP and Humsavar for OOEP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10805972 -- 73,371,772(+) aaaaa(A/T)aaaaa intron-variant, upstream-variant-2KB
rs10943091 -- 73,371,773(+) aaaat(A/T)aaaaa intron-variant, upstream-variant-2KB
rs113348342 -- 73,371,218(+) CCTCA(A/G)TGGTT intron-variant, upstream-variant-2KB
rs113362145 -- 73,371,756(+) AAAAA(-/T)AAAAA intron-variant, upstream-variant-2KB
rs117375145 -- 73,371,607(+) TAGCC(A/G)GACAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OOEP Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV loss 17160897

Variation tolerance for OOEP Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OOEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OOEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OOEP Gene

Disorders for OOEP Gene

Relevant External Links for OOEP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OOEP

No disorders were found for OOEP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OOEP Gene

Publications for OOEP Gene

  1. Atypical structure and phylogenomic evolution of the new eutherian oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. (PMID: 17913455) Pierre A. … Monget P. (Genomics 2007) 2 3 4 64
  2. TLE6 mutation causes the earliest known human embryonic lethality. (PMID: 26537248) Alazami A.M. … Alkuraya F.S. (Genome Biol. 2015) 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for OOEP Gene

Sources for OOEP Gene

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