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Aliases for ONECUT3 Gene

Aliases for ONECUT3 Gene

  • One Cut Homeobox 3 2 3 4
  • One Cut Domain, Family Member 3 2 3
  • Transcription Factor ONECUT-3 3 4
  • OC-3 3 4
  • OC3 3

External Ids for ONECUT3 Gene

Previous GeneCards Identifiers for ONECUT3 Gene

  • GC19U990205
  • GC19P001506

Summaries for ONECUT3 Gene

GeneCards Summary for ONECUT3 Gene

ONECUT3 (One Cut Homeobox 3) is a Protein Coding gene. Diseases associated with ONECUT3 include dracunculiasis. Among its related pathways are Developmental Biology and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for ONECUT3 Gene

  • Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT3 Gene

Genomics for ONECUT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ONECUT3 Gene

Chromosome:
19
Start:
1,752,373 bp from pter
End:
1,780,988 bp from pter
Size:
28,616 bases
Orientation:
Plus strand

Genomic View for ONECUT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ONECUT3 Gene

Proteins for ONECUT3 Gene

  • Protein details for ONECUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60422-ONEC3_HUMAN
    Recommended name:
    One cut domain family member 3
    Protein Accession:
    O60422
    Secondary Accessions:
    • A8MZM7

    Protein attributes for ONECUT3 Gene

    Size:
    494 amino acids
    Molecular mass:
    50037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ONECUT3 Gene

Proteomics data for ONECUT3 Gene at MOPED

Post-translational modifications for ONECUT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT3 Gene

Domains & Families for ONECUT3 Gene

Gene Families for ONECUT3 Gene

Protein Domains for ONECUT3 Gene

Suggested Antigen Peptide Sequences for ONECUT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60422

UniProtKB/Swiss-Prot:

ONEC3_HUMAN :
  • Contains 1 CUT DNA-binding domain.
  • Belongs to the CUT homeobox family.
Domain:
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT3: view

Function for ONECUT3 Gene

Molecular function for ONECUT3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Gene Ontology (GO) - Molecular Function for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding --
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
genes like me logo Genes that share ontologies with ONECUT3: view

Phenotypes for ONECUT3 Gene

MGI mutant phenotypes for ONECUT3:
inferred from 1 alleles
GenomeRNAi human phenotypes for ONECUT3:
genes like me logo Genes that share phenotypes with ONECUT3: view

Animal Model Products

CRISPR Products

miRNA for ONECUT3 Gene

miRTarBase miRNAs that target ONECUT3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ONECUT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ONECUT3 Gene

Localization for ONECUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ONECUT3 Gene COMPARTMENTS Subcellular localization image for ONECUT3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with ONECUT3: view

Pathways & Interactions for ONECUT3 Gene

genes like me logo Genes that share pathways with ONECUT3: view

Interacting Proteins for ONECUT3 Gene

Gene Ontology (GO) - Biological Process for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030154 cell differentiation IBA --
GO:0031018 endocrine pancreas development TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ONECUT3: view

No data available for SIGNOR curated interactions for ONECUT3 Gene

Drugs & Compounds for ONECUT3 Gene

No Compound Related Data Available

Transcripts for ONECUT3 Gene

mRNA/cDNA for ONECUT3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT3 Gene

One cut homeobox 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ONECUT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT3 Gene

No ASD Table

Relevant External Links for ONECUT3 Gene

GeneLoc Exon Structure for
ONECUT3
ECgene alternative splicing isoforms for
ONECUT3

Expression for ONECUT3 Gene

mRNA expression in normal human tissues for ONECUT3 Gene

mRNA differential expression in normal tissues according to GTEx for ONECUT3 Gene

This gene is overexpressed in Testis (x26.6), Stomach (x10.2), and Brain - Hypothalamus (x8.0).

SOURCE GeneReport for Unigene cluster for ONECUT3 Gene Hs.654347

genes like me logo Genes that share expression patterns with ONECUT3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ONECUT3 Gene

Orthologs for ONECUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ONECUT3 35
  • 90.67 (n)
  • 91.51 (a)
ONECUT3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ONECUT3 35
  • 94.14 (n)
  • 96.09 (a)
ONECUT3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Onecut3 16
Onecut3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ONECUT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves ONECUT3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ONECUT3 (2 of 2) 36
  • 65 (a)
OneToMany
onecut3a 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta onecut 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-48 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for ONECUT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ONECUT3 Gene

ENSEMBL:
Gene Tree for ONECUT3 (if available)
TreeFam:
Gene Tree for ONECUT3 (if available)

Paralogs for ONECUT3 Gene

Paralogs for ONECUT3 Gene

(2) SIMAP similar genes for ONECUT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ONECUT3: view

Variants for ONECUT3 Gene

Sequence variations from dbSNP and Humsavar for ONECUT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1319342 -- 1,756,750(+) accat(G/T)ttggc intron-variant
rs1987908 -- 1,756,680(+) GCCCG(C/T)CACCA intron-variant
rs1987909 -- 1,756,721(+) ttttg(G/T)atttt intron-variant
rs4807139 -- 1,757,732(+) CCTTT(A/C)GTTCC intron-variant
rs8100075 -- 1,752,856(+) CCCGA(C/G)GCCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ONECUT3 Gene

Variant ID Type Subtype PubMed ID
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
esv2671081 CNV Deletion 23128226
esv7507 CNV Gain 19470904
nsv910550 CNV Loss 21882294

Variation tolerance for ONECUT3 Gene

Gene Damage Index Score: 0.34; 7.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ONECUT3 Gene

HapMap Linkage Disequilibrium report
ONECUT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ONECUT3 Gene

Disorders for ONECUT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dracunculiasis
  • infection by dracunculus medinensis
- elite association

Relevant External Links for ONECUT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ONECUT3
genes like me logo Genes that share disorders with ONECUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT3 Gene

Publications for ONECUT3 Gene

  1. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 67
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  3. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PMID: 11944891) Vanhorenbeeck V. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2002) 67
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 67

Products for ONECUT3 Gene

Sources for ONECUT3 Gene

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