Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ONECUT3 Gene

protein-coding   GIFtS: 46
GCID: GC19P001727

one cut homeobox 3

(Previous names: one cut domain, family member 3 )
 Explore 4 diseases affiliated with
ONECUT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ONECUT3    

Aliases
for ONECUT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
One Cut Homeobox 31 2 3
One Cut Domain, Family Member 31 2
Transcription Factor ONECUT-32 3
OC-32 3
OC32
One Cut Domain Family Member 32

External Ids:    HGNC: 133991   Entrez Gene: 3908742   Ensembl: ENSG000002059227   OMIM: 6112945   UniProtKB: O604223   

Export aliases for ONECUT3 gene to outside databases

Previous GC identifers: GC19U990205 GC19P001506


Summaries
for ONECUT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
promoters such as those of HNF3B and TTR (By similarity)




Genomic Views
for ONECUT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ONECUT3 gene promoter:
         NF-1/L   NF-1   HSF1 (long)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MZF-1   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ONECUT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ONECUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ONECUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001727:  view genomic region     (about GC identifiers)

Start:
 1,752,372 bp from pter      End:
 1,780,987 bp from pter
Size:
 28,616 bases      Orientation:
 plus strand

Proteins
for ONECUT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422 (See protein sequence)
Recommended Name: One cut domain family member 3  
Size: 494 amino acids; 50037 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8MZM7

Explore the universe of human proteins at neXtProt for ONECUT3: NX_O60422

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60422

    • ONECUT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073957.1  
    ENSEMBL proteins: 
     ENSP00000371786  
    Reactome Protein details: O60422
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ONECUT3 
    GenScript Custom Purified and Recombinant Proteins Services for ONECUT3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ONECUT3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IEA--


    ONECUT3 for ontologies           About GeneDecksing



    ONECUT3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ONECUT3 
    GenScript Custom Superior Antibodies Services for ONECUT3
    Novus Biologicals ONECUT3 Antibodies
    Search for Antibodies for ONECUT3 at Abcam  
    Uscn Antibodies for ONECUT3
    Search ThermoFisher Antibodies for ONECUT3

    Assay Products for ONECUT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ONECUT3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ONECUT3

    Protein Domains /
    Families
    for ONECUT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ONECUT3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60422

    ProtoNet protein and cluster: O60422

    UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
    Similarity: Contains 1 CUT DNA-binding domain
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for ONECUT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
    Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
    promoters such as those of HNF3B and TTR (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ONECUT3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ONECUT3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ONECUT3 (see all 4)
    OriGene shRNA RFP: ONECUT3
    OriGene siRNA: ONECUT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ONECUT3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ONECUT3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ONECUT3 (NM_001080488)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ONECUT3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ONECUT3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ONECUT3
    Search LifeMap BioReagents cell lines for ONECUT3

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ONECUT3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    ONECUT3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ONECUT3:
     Low eccentricity cells 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Onecut3):
     endocrine/exocrine gland 

    ONECUT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ONECUT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NOTCH1 stimulates HES1 transcription
    		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells0.25
    		HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification0.00
    		HNF6-dependent synthesis of ONECUT3 protein during morphogenesis0.00
    2Regulation of gene expression in early pancreatic precursor cells
    		Regulation of gene expression in early pancreatic precursor cells1.00
    3Regulation of beta-cell development
    		Regulation of beta-cell development1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for ONECUT3 (see all 6)
        Developmental Biology
    Regulation of beta-cell development
    HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification
    HNF6-dependent synthesis of ONECUT3 protein during morphogenesis
    Regulation of gene expression in early pancreatic precursor cells



    ONECUT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ONECUT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ONECUT3 (ENSP000003717864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0031018endocrine pancreas development TAS--


    ONECUT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ONECUT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ONECUT3
    Search CenterWatch for drugs/clinical trials and news about ONECUT3 / ONEC3 

    Transcripts
    for ONECUT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ONECUT3 gene: 
    NM_001080488.1  

    Unigene Cluster for ONECUT3:

    One cut homeobox 3
    Hs.654347  [show with all ESTs]
    Unigene Representative Sequence: NM_001080488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382349(uc010xgr.2)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ONECUT3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ONECUT3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ONECUT3 (see all 4)
    OriGene shRNA RFP: ONECUT3
    OriGene siRNA: ONECUT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ONECUT3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ONECUT3 (NM_001080488)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ONECUT3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ONECUT3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ONECUT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ONECUT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ONECUT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ONECUT3

    1 DOTS entry:

    DT.92065466 

    1 AceView cDNA sequence:

    BX283788 

    GeneLoc Exon Structure


    Expression
    for ONECUT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ONECUT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCGCTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ONECUT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See ONECUT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ONECUT3

    SOURCE GeneReport for Unigene cluster: Hs.654347
        SABiosciences Custom PCR Arrays for ONECUT3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ONECUT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ONECUT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ONECUT3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ONECUT3
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ONECUT3

    Orthologs
    for ONECUT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ONECUT3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Onecut31 , 5 one cut domain, family member 31, 5 87.81(n)1
    94.01(a)1    		   10 (39.72 cM)5
    2460861  NM_139226.31  NP_631972.21 
     804948355 
    lizard
    (Anolis carolinensis)    		 Reptilia ONECUT16
    		 --
    		 50(a)
    		 1 ↔ 1
    		 GL343862.1(103045-134046)
    zebrafish
    (Danio rerio)    		 Actinopterygii onecut31 one cut homeobox 3 68.3(n)
    70.09(a)    		   565854  XM_689117.1  XP_694209.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta onecut6
    		 onecut
    		 13(a)
    		 1 → many
    		 4(619181-628351)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-486
    ceh-396
    (see all 5)    		 Homeobox protein ceh-39
    (see all 5)    		 27(a)
    22(a)
    (see all 5)    		 many → 1
    possible ortholog
    (see all 5)    		 IV(6812095-6815570)
    X(1854142-1856166)


    ENSEMBL Gene Tree for ONECUT3 (if available)
    TreeFam Gene Tree for ONECUT3 (if available) 

    Paralogs
    for ONECUT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ONECUT3 gene
    CUX22  ONECUT12  ONECUT22  CUX12  
    2 SIMAP similar genes for ONECUT3 using alignment to 1 protein entry:     ONEC3_HUMAN:
    ONECUT1    ONECUT2

    ONECUT3 for paralogs           About GeneDecksing



    Genomic Variants
    for ONECUT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/419 NCBI SNPs in ONECUT3 are shown (see all 419)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161126471,2
    		--1751756(+) AGGGGG/AGAACT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1831397131,2
    		--1751774(+) CACCAC/TCCCCC 1 -- us2k10--------
    rs1458597391,2
    		C,--1751796(+) AGAGAC/TACCCG 1 -- us2k10--------
    rs797725581,2
    		F,--1751898(+) AGCAGC/TGAGTA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1385072991,2
    		--1751974(+) GCCCAA/GATCAT 1 -- us2k10--------
    rs1144371551,2
    		F,--1752147(+) ATCTCC/TAATGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2000632161,2
    		--1752390(+) GGGGT-/GGGGGG 1 -- us2k10--------
    rs1487097341,2
    		C,--1752392(+) GGTGG-/AGGGGG 1 -- us2k10--------
    rs1150005951,2
    		F,--1752517(+) GCAGCC/TCTGAC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs797830871,2
    		--1752564(+) TCTCTG/CATTAT 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for ONECUT3 (1752372 - 1780987 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ONECUT3
         1 CNV: 7191
         1 Indel: 60269

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ONECUT3
    DNA2.0 Custom Variant and Variant Library Synthesis for ONECUT3

    Disorders / Diseases
    for ONECUT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ONECUT3 for disorders           About GeneDecksing

    OMIM gene information: 611294    OMIM disorders: --

    4 diseases for ONECUT3:    About MalaCards
    loiasis    dracunculiasis    onchocerciasis    pancreatitis

    4 diseases from the University of Copenhagen DISEASES database for ONECUT3:
    Onchocerciasis     Dracunculiasis     Loiasis     Pulmonary venoocclusive disease

    Export disorders for ONECUT3 gene to outside databases

    Publications
    for ONECUT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ONECUT3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ONECUT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PubMed id 11944891)1, 2 Vanhorenbeeck V.... Rousseau G.G. (2002)
    3. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PubMed id 9915796)1, 3 Jacquemin P.... Lemaigre F.P. (1999)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    External Searches for ONECUT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ONECUT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390874 HGNC: 13399 AceView: LOC390874 Ensembl:ENSG00000205922 euGenes: HUgn390874
    ECgene: ONECUT3 H-InvDB: ONECUT3

    Other Databases showing ONECUT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ONECUT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ONECUT3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ONECUT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ONECUT3 gene:
    Search GeneIP for patents involving ONECUT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ONECUT3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ONECUT3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ONECUT3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ONECUT3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ONECUT3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ONECUT3   OriGene Custom Protein Services for ONECUT3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ONECUT3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ONECUT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ONECUT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ONECUT3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ONECUT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ONECUT3
     GenScript Custom Purified and Recombinant Proteins Services for ONECUT3 GenScript cDNA clones with any tag delivered in your preferred vector for ONECUT3
     GenScript Custom Assay Services for ONECUT3 GenScript Custom Superior Antibodies Services for ONECUT3
     GenScript Custom overexpressing Cell Line Services for ONECUT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ONECUT3 promoter
     Search Chromatin IP Primers for ONECUT3
     RT2 qPCR Primer Assay in human, mouse, rat ONECUT3
     Search GNC Networks for ONECUT3
     SABiosciences Custom PCR Arrays for ONECUT3
     Search Tocris compounds for ONECUT3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ONECUT3 antibodies
     Search for Antibodies for ONECUT3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ONECUT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ONECUT3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ONECUT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ONECUT3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ONECUT3
     Browse SwitchGear Promoter luciferase reporter plasmids for ONECUT3
     Search ThermoFisher Antibodies for ONECUT3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ONECUT3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ONECUT3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4