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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ONECUT3 Gene

protein-coding   GIFtS: 46
GCID: GC19P001727

One Cut Homeobox 3

(Previous names: one cut domain, family member 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
One Cut Homeobox 31 2 3
One Cut Domain, Family Member 31 2
Transcription Factor ONECUT-32 3
OC-32 3
OC32
One Cut Domain Family Member 32

External Ids:    HGNC: 133991   Entrez Gene: 3908742   Ensembl: ENSG000002059227   OMIM: 6112945   UniProtKB: O604223   

Export aliases for ONECUT3 gene to outside databases

Previous GC identifers: GC19U990205 GC19P001506


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ONECUT3 Gene: 
ONECUT3 (one cut homeobox 3) is a protein-coding gene. Diseases associated with ONECUT3 include loiasis, and pulmonary venoocclusive disease, and among its related super-pathways are Axon guidance and Maturity onset diabetes of the young. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CUX2.

UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
promoters such as those of HNF3B and TTR (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ONECUT3 gene promoter:
         NF-1/L   NF-1   HSF1 (long)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MZF-1   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ONECUT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ONECUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ONECUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001727:  view genomic region     (about GC identifiers)

Start:
1,752,372 bp from pter      End:
1,780,987 bp from pter
Size:
28,616 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422 (See protein sequence)
Recommended Name: One cut domain family member 3  
Size: 494 amino acids; 50037 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8MZM7

Explore the universe of human proteins at neXtProt for ONECUT3: NX_O60422

Explore proteomics data for ONECUT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60422

  • ONECUT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ONECUT3 Protein Expression
    REFSEQ proteins: NP_001073957.1  
    ENSEMBL proteins: 
     ENSP00000371786  
    Reactome Protein details: O60422
    Human Recombinant Protein Products for ONECUT3: 
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    Cloud-Clone Corp. Proteins for ONECUT3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    ONECUT3 for ontologies           About GeneDecksing



    ONECUT3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CUT: Homeoboxes / CUT class

    4 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60422

    ProtoNet protein and cluster: O60422

    UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
    Similarity: Contains 1 CUT DNA-binding domain
    Similarity: Contains 1 homeobox DNA-binding domain


    ONECUT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ONEC3_HUMAN, O60422
    Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
    promoters such as those of HNF3B and TTR (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    ONECUT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ONECUT3:
     Low eccentricity cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Onecut3):
     endocrine/exocrine gland 

    ONECUT3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ONECUT3 
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    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ONECUT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Regulation of beta-cell development
    Regulation of beta-cell development0.56
    3Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    4Regulation of gene expression in early pancreatic precursor cells
    Regulation of gene expression in early pancreatic precursor cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for ONECUT3
        Developmental Biology
    Regulation of beta-cell development
    Regulation of gene expression in early pancreatic precursor cells
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells



    ONECUT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ONECUT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ONECUT3 (ENSP000003717864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0031018endocrine pancreas development TAS--

    ONECUT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ONECUT3 (ONEC3)

    Search CenterWatch for drugs/clinical trials and news about ONECUT3 / ONEC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ONECUT3 gene: 
    NM_001080488.1  

    Unigene Cluster for ONECUT3:

    One cut homeobox 3
    Hs.654347  [show with all ESTs]
    Unigene Representative Sequence: NM_001080488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382349(uc010xgr.2)
    miRNA
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    1 DOTS entry:

    DT.92065466 

    1 AceView cDNA sequence:

    BX283788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ONECUT3 expression in normal human tissues (normalized intensities)      ONECUT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCGCTGGG
    ONECUT3 Expression
    About this image


    ONECUT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See ONECUT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ONECUT3

    SOURCE GeneReport for Unigene cluster: Hs.654347
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ONECUT3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Onecut31 , 5 one cut domain, family member 31, 5 87.81(n)1
    94.01(a)1
      10 (39.72 cM)5
    2460861  NM_139226.31  NP_631972.21 
     804948355 
    chicken
    (Gallus gallus)
    Aves ONECUT36
    one cut homeobox 3
    66(a)
    1 ↔ 1
    28(2233927-2250905)
    zebrafish
    (Danio rerio)
    Actinopterygii onecut31 one cut homeobox 3 68.3(n)
    70.09(a)
      565854  XM_689117.1  XP_694209.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta onecut6
    onecut
    16(a)
    1 → many
    4(619181-628351)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-486
    ceh-386
    Homeobox protein ceh-38
    33(a)
    18(a)
    many → 1
    possible ortholog
    IV(6812106-6815581)
    II(6951640-6955408)


    ENSEMBL Gene Tree for ONECUT3 (if available)
    TreeFam Gene Tree for ONECUT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ONECUT3 gene
    CUX22  ONECUT12  ONECUT22  CUX12  
    2 SIMAP similar genes for ONECUT3 using alignment to 1 protein entry:     ONEC3_HUMAN:
    ONECUT1    ONECUT2

    ONECUT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/519 SNPs in ONECUT3 are shown (see all 519)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161126471,2
    C,F--1751756(+) AGGGGG/AGAACT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1831397131,2
    --1751774(+) CACCAC/TCCCCC 1 -- us2k10--------
    rs1458597391,2
    C--1751796(+) AGAGAC/TACCCG 1 -- us2k10--------
    rs797725581,2
    C,F--1751898(+) AGCAGC/TGAGTA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1385072991,2
    C--1751974(+) GCCCAA/GATCAT 1 -- us2k10--------
    rs1144371551,2
    C,F--1752147(+) ATCTCC/TAATGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2000632161,2
    C--1752390(+) GGGGT-/G/GG  
            
    GGGGG
    1 -- us2k10--------
    rs1487097341,2
    C--1752392(+) GGTGG-/AGGGGG 1 -- us2k10--------
    rs1150005951,2
    C,F--1752517(+) GCAGCC/TCTGAC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs797830871,2
    F--1752564(+) TCTCTG/CATTAT 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for ONECUT3 (1752372 - 1780987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ONECUT3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671081CNV Deletion23128226
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3612n71CNV Loss21882294
    dgv3583n71CNV Loss21882294
    dgv3609n71CNV Loss21882294
    nsv910545CNV Loss21882294
    dgv3613n71CNV Loss21882294
    nsv910550CNV Loss21882294
    esv7507CNV Gain19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611294    OMIM disorders: --

    5 diseases for ONECUT3:    About MalaCards
    loiasis    pulmonary venoocclusive disease    dracunculiasis    onchocerciasis
    pancreatitis

    4 diseases from the University of Copenhagen DISEASES database for ONECUT3:
    Onchocerciasis     Dracunculiasis     Pulmonary venoocclusive disease     Loiasis

    ONECUT3 for disorders           About GeneDecksing


    Export disorders for ONECUT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ONECUT3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ONECUT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PubMed id 11944891)1, 2 Vanhorenbeeck V.... Rousseau G.G. (2002)
    3. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PubMed id 9915796)1, 3 Jacquemin P.... Lemaigre F.P. (1999)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390874 HGNC: 13399 AceView: LOC390874 Ensembl:ENSG00000205922 euGenes: HUgn390874
    ECgene: ONECUT3 H-InvDB: ONECUT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ONECUT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ONECUT3 gene:
    Search GeneIP for patents involving ONECUT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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