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ONECUT3 Gene

protein-coding   GIFtS: 46
GCID: GC19P001727

One Cut Homeobox 3

(Previous names: one cut domain, family member 3)
  See ONECUT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
One Cut Homeobox 31 2 3
One Cut Domain, Family Member 31 2
Transcription Factor ONECUT-32 3
OC-32 3
OC32 5
One Cut Domain Family Member 32

External Ids:    HGNC: 133991   Entrez Gene: 3908742   Ensembl: ENSG000002059227   OMIM: 6112945   UniProtKB: O604223   

Export aliases for ONECUT3 gene to outside databases

Previous GC identifers: GC19U990205 GC19P001506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ONECUT3 Gene:
ONECUT3 (one cut homeobox 3) is a protein-coding gene. Diseases associated with ONECUT3 include loiasis, and dracunculiasis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CUX2.

UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
promoters such as those of HNF3B and TTR (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ONECUT3 gene promoter:
         NF-1/L   NF-1   HSF1 (long)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MZF-1   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ONECUT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ONECUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ONECUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001727:  view genomic region     (about GC identifiers)

Start:
1,752,372 bp from pter      End:
1,780,987 bp from pter
Size:
28,616 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422 (See protein sequence)
Recommended Name: One cut domain family member 3  
Size: 494 amino acids; 50037 Da
Secondary accessions: A8MZM7

Explore the universe of human proteins at neXtProt for ONECUT3: NX_O60422

Explore proteomics data for ONECUT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ONECUT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073957.1  
    ENSEMBL proteins: 
     ENSP00000371786  
    Reactome Protein details: O60422

    ONECUT3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ONECUT3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CUT: Homeoboxes / CUT class

    4 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60422

    ProtoNet protein and cluster: O60422

    UniProtKB/Swiss-Prot: ONEC3_HUMAN, O60422
    Similarity: Contains 1 CUT DNA-binding domain
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with ONECUT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ONEC3_HUMAN, O60422
    Function: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
    promoters such as those of HNF3B and TTR (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ONECUT3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ONECUT3:
     Low eccentricity cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Onecut3):
     endocrine/exocrine gland 

    Find genes that share phenotypes with ONECUT3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ONECUT3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ONECUT3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ONEC3_HUMAN, O60422: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with ONECUT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ONECUT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells0.00
    Regulation of gene expression in early pancreatic precursor cells0.00
    2L1CAM interactions
    Developmental Biology0.63


    Find genes that share SuperPaths with ONECUT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ONECUT3
        Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    Regulation of gene expression in early pancreatic precursor cells


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ONECUT3
    Interactions:

        Search GeneGlobe Interaction Network for ONECUT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ONECUT3 (ENSP000003717864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0031018endocrine pancreas development TAS--

    Find genes that share ontologies with ONECUT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ONECUT3 (ONEC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ONECUT3 gene: 
    NM_001080488.1  

    Unigene Cluster for ONECUT3:

    One cut homeobox 3
    Hs.654347  [show with all ESTs]
    Unigene Representative Sequence: NM_001080488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000382349(uc010xgr.2)
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ONECUT3
      QuantiTect SYBR Green Assays in human, mouse, rat ONECUT3
      QuantiFast Probe-based Assays in human, mouse, rat ONECUT3

    1 DOTS entry:

    DT.92065466 

    1 AceView cDNA sequence:

    BX283788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ONECUT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCGCTGGG
    ONECUT3 Expression
    About this image


    ONECUT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
    ONECUT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ONECUT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654347
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ONECUT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ONECUT3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Onecut35 one cut domain, family member 3   --   10 (39.72 cM) 80494835 
    chicken
    (Gallus gallus)
    Aves ONECUT36
    one cut homeobox 3
    69(a)
    1 ↔ 1
    28(2233927-2250905)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    53(a)
    many ↔ many
    GL343862.1(103045-134149)
    zebrafish
    (Danio rerio)
    Actinopterygii ONECUT3 (2 of 2)6
    onecut3a6
    one cut homeobox 3a
    65(a)
    64(a)
    many → 1
    many → 1
    2(57978989-58038804) ENSDARG00000091059
    22(20781834-20793913) ENSDARG00000056395
    fruit fly
    (Drosophila melanogaster)
    Insecta onecut6
    onecut
    18(a)
    1 → many
    4(619181-628351)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-486
    Protein CEH-48 (ceh-48) mRNA, complete cds
    34(a)
    1 → many
    IV(6812108-6815581) WBGene00015934


    ENSEMBL Gene Tree for ONECUT3 (if available)
    TreeFam Gene Tree for ONECUT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ONECUT3 gene
    CUX22  ONECUT12  ONECUT22  CUX12  
    2 SIMAP similar genes for ONECUT3 using alignment to 1 protein entry:     ONEC3_HUMAN:
    ONECUT1    ONECUT2

    Find genes that share paralogs with ONECUT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ONECUT3 (see all 519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161126471,2
    C,F--1751756(+) AGGGGG/AGAACT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1831397131,2
    --1751774(+) CACCAC/TCCCCC 1 -- us2k10--------
    rs1458597391,2
    C--1751796(+) AGAGAC/TACCCG 1 -- us2k10--------
    rs797725581,2
    C,F--1751898(+) AGCAGC/TGAGTA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1385072991,2
    C--1751974(+) GCCCAA/GATCAT 1 -- us2k10--------
    rs1144371551,2
    C,F--1752147(+) ATCTCC/TAATGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2000632161,2
    C--1752390(+) GGGGT-/G/GG  
            
    GGGGG
    1 -- us2k10--------
    rs1487097341,2
    C--1752392(+) GGTGG-/AGGGGG 1 -- us2k10--------
    rs1150005951,2
    C,F--1752517(+) GCAGCC/TCTGAC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs797830871,2
    F--1752564(+) TCTCTG/CATTAT 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for ONECUT3 (1752372 - 1780987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ONECUT3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671081CNV Deletion23128226
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3612n71CNV Loss21882294
    dgv3583n71CNV Loss21882294
    dgv3609n71CNV Loss21882294
    nsv910545CNV Loss21882294
    dgv3613n71CNV Loss21882294
    nsv910550CNV Loss21882294
    esv7507CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611294    OMIM disorders: --

    3 diseases for ONECUT3:    
    About MalaCards
    loiasis    dracunculiasis    pulmonary venoocclusive disease

    4 diseases from the University of Copenhagen DISEASES database for ONECUT3:
    Onchocerciasis     Dracunculiasis     Pulmonary venoocclusive disease     Loiasis

    Find genes that share disorders with ONECUT3           About GenesLikeMe


    Export disorders for ONECUT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ONECUT3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ONECUT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PubMed id 11944891)1, 2 Vanhorenbeeck V.... Rousseau G.G. (Biochem. Biophys. Res. Commun. 2002)
    3. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PubMed id 9915796)1, 3 Jacquemin P.... Lemaigre F.P. (J. Biol. Chem. 1999)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390874 HGNC: 13399 AceView: LOC390874 Ensembl:ENSG00000205922 euGenes: HUgn390874
    ECgene: ONECUT3 H-InvDB: ONECUT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ONECUT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ONECUT3 gene:
    Search GeneIP for patents involving ONECUT3

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Block miRNA regulation of human, mouse, rat ONECUT3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ONECUT3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ONECUT3 Predesigned siRNA for gene silencing in human, mouse, rat ONECUT3
     QuantiFast Probe-based Assays in human, mouse, rat ONECUT3 QuantiTect SYBR Green Assays in human, mouse, rat ONECUT3
     Custom PCR Arrays for ONECUT3 Search Chromatin IP Primers for ONECUT3
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     Search Addgene for plasmids for ONECUT3
      Search eBioscience for proteins for ONECUT3
      Search eBioscience for elisas for ONECUT3
      eBioscience FlowRNA Probe Sets
           
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