Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ONECUT3 Gene

Aliases for ONECUT3 Gene

  • One Cut Homeobox 3 2 3 4 5
  • Transcription Factor ONECUT-3 3 4
  • OC-3 3 4
  • One Cut Domain, Family Member 3 2
  • One Cut Domain Family Member 3 3
  • OC3 3

External Ids for ONECUT3 Gene

Previous GeneCards Identifiers for ONECUT3 Gene

  • GC19U990205
  • GC19P001506

Summaries for ONECUT3 Gene

GeneCards Summary for ONECUT3 Gene

ONECUT3 (One Cut Homeobox 3) is a Protein Coding gene. Diseases associated with ONECUT3 include Dracunculiasis. Among its related pathways are Regulation of beta-cell development and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT2.

UniProtKB/Swiss-Prot for ONECUT3 Gene

  • Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT3 Gene

Genomics for ONECUT3 Gene

Regulatory Elements for ONECUT3 Gene

Enhancers for ONECUT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001718 0.4 Ensembl 12.2 -33.5 -33488 1.1 SMARCA4 IKZF1 ZIC2 EZH2 ONECUT3 ATP8B3 MIR1909 REXO1 TCF3 ENSG00000275642 GC19P001681 GC19P001682
GH19F001725 1.2 FANTOM5 Ensembl ENCODE 12 -26.5 -26531 1.3 ELF3 ZNF133 ZFP64 DEAF1 ARID4B ZNF48 ZBTB40 KAT2B ZNF335 ZNF121 ONECUT3 ATP8B3 MIR1909 REXO1 RNU6-1223P TCF3 APC2 MUM1 CBARP ENSG00000275642
GH19F001657 0.8 FANTOM5 Ensembl 4.1 -94.2 -94173 1.2 PKNOX1 TEAD3 E2F1 HIC1 CTBP1 ZBTB48 PATZ1 FOS ZBTB10 MAZ ONECUT3 EFNA2 GC19M001661 TCF3
GH19F001744 1.1 FANTOM5 Ensembl ENCODE 2.1 -4.5 -4534 7.1 HDGF PKNOX1 ARNT ZNF2 YY1 ZNF766 CBX5 FOS KLF13 ZNF263 SCAMP4 CIRBP ENSG00000266990 LINC01775 C19orf24 ATP8B3 MIR1909 REXO1 TMEM259 TCF3
GH19F001283 1.1 FANTOM5 ENCODE 1.2 -467.8 -467839 2.5 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 SP5 PPARG ZNF623 EFNA2 C19orf24 REEP6 GAMT ONECUT3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ONECUT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ONECUT3 Gene

Chromosome:
19
Start:
1,752,373 bp from pter
End:
1,780,988 bp from pter
Size:
28,616 bases
Orientation:
Plus strand

Genomic View for ONECUT3 Gene

Genes around ONECUT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT3 Gene

Proteins for ONECUT3 Gene

  • Protein details for ONECUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60422-ONEC3_HUMAN
    Recommended name:
    One cut domain family member 3
    Protein Accession:
    O60422
    Secondary Accessions:
    • A8MZM7

    Protein attributes for ONECUT3 Gene

    Size:
    494 amino acids
    Molecular mass:
    50037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ONECUT3 Gene

Post-translational modifications for ONECUT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT3 Gene

Domains & Families for ONECUT3 Gene

Gene Families for ONECUT3 Gene

Protein Domains for ONECUT3 Gene

Suggested Antigen Peptide Sequences for ONECUT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60422

UniProtKB/Swiss-Prot:

ONEC3_HUMAN :
  • Contains 1 CUT DNA-binding domain.
  • Belongs to the CUT homeobox family.
Domain:
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT3: view

Function for ONECUT3 Gene

Molecular function for ONECUT3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Gene Ontology (GO) - Molecular Function for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ONECUT3: view

Phenotypes for ONECUT3 Gene

genes like me logo Genes that share phenotypes with ONECUT3: view

Animal Model Products

miRNA for ONECUT3 Gene

miRTarBase miRNAs that target ONECUT3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ONECUT3 Gene

Localization for ONECUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ONECUT3 Gene COMPARTMENTS Subcellular localization image for ONECUT3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with ONECUT3: view

Pathways & Interactions for ONECUT3 Gene

genes like me logo Genes that share pathways with ONECUT3: view

Interacting Proteins for ONECUT3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371786%0d%0a9606.ENSP00000302630%0d%0a9606.ENSP00000225893%0d%0a9606.ENSP00000406738%0d%0a9606.ENSP00000231509%0d%0a9606.ENSP00000274031%0d%0a
Selected Interacting proteins: ENSP00000371786 O60422-ONEC3_HUMAN for ONECUT3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ONECUT3: view

No data available for SIGNOR curated interactions for ONECUT3 Gene

Transcripts for ONECUT3 Gene

mRNA/cDNA for ONECUT3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT3 Gene

One cut homeobox 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT3 Gene

No ASD Table

Relevant External Links for ONECUT3 Gene

GeneLoc Exon Structure for
ONECUT3
ECgene alternative splicing isoforms for
ONECUT3

Expression for ONECUT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ONECUT3 Gene

mRNA differential expression in normal tissues according to GTEx for ONECUT3 Gene

This gene is overexpressed in Testis (x26.6), Stomach (x10.2), and Brain - Hypothalamus (x8.0).

NURSA nuclear receptor signaling pathways regulating expression of ONECUT3 Gene:

ONECUT3

SOURCE GeneReport for Unigene cluster for ONECUT3 Gene:

Hs.654347
genes like me logo Genes that share expression patterns with ONECUT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ONECUT3 Gene

Orthologs for ONECUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ONECUT3 34 35
  • 94.14 (n)
mouse
(Mus musculus)
Mammalia Onecut3 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ONECUT3 34 35
  • 90.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ONECUT3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ONECUT3 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ONECUT3 (2 of 2) 35
  • 65 (a)
OneToMany
onecut3a 35
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta onecut 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-48 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for ONECUT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ONECUT3 Gene

ENSEMBL:
Gene Tree for ONECUT3 (if available)
TreeFam:
Gene Tree for ONECUT3 (if available)

Paralogs for ONECUT3 Gene

Paralogs for ONECUT3 Gene

(2) SIMAP similar genes for ONECUT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ONECUT3: view

Variants for ONECUT3 Gene

Sequence variations from dbSNP and Humsavar for ONECUT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402793 -- 1,762,156(+) TCCCC(C/T)TGGAC intron-variant
rs10404100 -- 1,769,972(+) ACCTC(C/T)CTCCC intron-variant
rs10404454 -- 1,770,786(+) TTCCT(C/T)CCATG intron-variant
rs10404955 -- 1,762,735(+) CCACC(A/G)TCCCA intron-variant
rs10408726 -- 1,775,684(+) CCACC(A/C)CCCCC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ONECUT3 Gene

Variant ID Type Subtype PubMed ID
esv2671081 CNV deletion 23128226
esv32942 CNV gain+loss 17666407
esv3893156 CNV loss 25118596
esv7507 CNV gain 19470904
nsv1072301 CNV deletion 25765185
nsv1129613 CNV tandem duplication 24896259
nsv1136265 CNV deletion 24896259
nsv1146134 CNV insertion 26484159
nsv953942 CNV deletion 24416366

Variation tolerance for ONECUT3 Gene

Gene Damage Index Score: 0.34; 7.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ONECUT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ONECUT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ONECUT3 Gene

Disorders for ONECUT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dracunculiasis
  • dracontiasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ONECUT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ONECUT3
genes like me logo Genes that share disorders with ONECUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT3 Gene

Publications for ONECUT3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PMID: 11944891) Vanhorenbeeck V. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2002) 3 4 64
  3. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for ONECUT3 Gene

Sources for ONECUT3 Gene

Content
Loading form....