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Aliases for ONECUT3 Gene

Aliases for ONECUT3 Gene

  • One Cut Homeobox 3 2 3 4 5
  • One Cut Domain, Family Member 3 2 3
  • Transcription Factor ONECUT-3 3 4
  • OC-3 3 4
  • OC3 3

External Ids for ONECUT3 Gene

Previous GeneCards Identifiers for ONECUT3 Gene

  • GC19U990205
  • GC19P001506

Summaries for ONECUT3 Gene

GeneCards Summary for ONECUT3 Gene

ONECUT3 (One Cut Homeobox 3) is a Protein Coding gene. Diseases associated with ONECUT3 include Dracunculiasis. Among its related pathways are Developmental Biology and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for ONECUT3 Gene

  • Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT3 Gene

Genomics for ONECUT3 Gene

Regulatory Elements for ONECUT3 Gene

Enhancers for ONECUT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ONECUT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ONECUT3 Gene

1,752,373 bp from pter
1,780,988 bp from pter
28,616 bases
Plus strand

Genomic View for ONECUT3 Gene

Genes around ONECUT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT3 Gene

Proteins for ONECUT3 Gene

  • Protein details for ONECUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    One cut domain family member 3
    Protein Accession:
    Secondary Accessions:
    • A8MZM7

    Protein attributes for ONECUT3 Gene

    494 amino acids
    Molecular mass:
    50037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ONECUT3 Gene

Proteomics data for ONECUT3 Gene at MOPED

Post-translational modifications for ONECUT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT3 Gene

Domains & Families for ONECUT3 Gene

Gene Families for ONECUT3 Gene

Protein Domains for ONECUT3 Gene

Suggested Antigen Peptide Sequences for ONECUT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUT DNA-binding domain.
  • Belongs to the CUT homeobox family.
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT3: view

Function for ONECUT3 Gene

Molecular function for ONECUT3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus DNA sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Gene Ontology (GO) - Molecular Function for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with ONECUT3: view

Phenotypes for ONECUT3 Gene

genes like me logo Genes that share phenotypes with ONECUT3: view

Animal Model Products

CRISPR Products

miRNA for ONECUT3 Gene

miRTarBase miRNAs that target ONECUT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ONECUT3 Gene

Localization for ONECUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT3 Gene

Subcellular locations from

Jensen Localization Image for ONECUT3 Gene COMPARTMENTS Subcellular localization image for ONECUT3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ONECUT3 Gene

Pathways & Interactions for ONECUT3 Gene

genes like me logo Genes that share pathways with ONECUT3: view

Interacting Proteins for ONECUT3 Gene

Gene Ontology (GO) - Biological Process for ONECUT3 Gene


No data available for SIGNOR curated interactions for ONECUT3 Gene

Drugs & Compounds for ONECUT3 Gene

No Compound Related Data Available

Transcripts for ONECUT3 Gene

mRNA/cDNA for ONECUT3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT3 Gene

One cut homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT3 Gene

No ASD Table

Relevant External Links for ONECUT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ONECUT3 Gene

mRNA expression in normal human tissues for ONECUT3 Gene

mRNA differential expression in normal tissues according to GTEx for ONECUT3 Gene

This gene is overexpressed in Testis (x26.6), Stomach (x10.2), and Brain - Hypothalamus (x8.0).

SOURCE GeneReport for Unigene cluster for ONECUT3 Gene Hs.654347

genes like me logo Genes that share expression patterns with ONECUT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ONECUT3 Gene

Orthologs for ONECUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ONECUT3 35
  • 90.67 (n)
  • 91.51 (a)
  • 95 (a)
(Canis familiaris)
Mammalia ONECUT3 35
  • 94.14 (n)
  • 96.09 (a)
  • 97 (a)
(Monodelphis domestica)
Mammalia ONECUT3 36
  • 72 (a)
(Mus musculus)
Mammalia Onecut3 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 88 (a)
(Gallus gallus)
Aves ONECUT3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
(Danio rerio)
Actinopterygii ONECUT3 (2 of 2) 36
  • 65 (a)
onecut3a 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta onecut 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea ceh-48 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for ONECUT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ONECUT3 Gene

Gene Tree for ONECUT3 (if available)
Gene Tree for ONECUT3 (if available)

Paralogs for ONECUT3 Gene

Paralogs for ONECUT3 Gene

(2) SIMAP similar genes for ONECUT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ONECUT3: view

Variants for ONECUT3 Gene

Sequence variations from dbSNP and Humsavar for ONECUT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8100075 -- 1,752,856(+) CCCGA(C/G)GCCGG upstream-variant-2KB
rs8100213 -- 1,759,146(+) ACAAA(A/T)ACCAG intron-variant
rs8100623 -- 1,759,876(+) GGCCA(C/T)GAGAA intron-variant
rs8102094 -- 1,763,045(+) agacc(C/G)catct intron-variant
rs12982359 -- 1,758,298(+) gagag(A/C)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT3 Gene

Variant ID Type Subtype PubMed ID
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
esv2671081 CNV Deletion 23128226
esv7507 CNV Gain 19470904
nsv910550 CNV Loss 21882294

Variation tolerance for ONECUT3 Gene

Gene Damage Index Score: 0.34; 7.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ONECUT3 Gene

Disorders for ONECUT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • dracontiasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ONECUT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ONECUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT3 Gene

Publications for ONECUT3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 3
  3. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PMID: 11944891) Vanhorenbeeck V. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2002) 3
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for ONECUT3 Gene

Sources for ONECUT3 Gene