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Aliases for ONECUT2 Gene

Aliases for ONECUT2 Gene

  • One Cut Homeobox 2 2 3 4 5
  • Hepatocyte Nuclear Factor 6-Beta 3 4
  • Transcription Factor ONECUT-2 3 4
  • HNF-6-Beta 3 4
  • OC-2 3 4
  • ONECUT-2 Homeodomain Transcription Factor 3
  • One Cut Domain, Family Member 2 2
  • One Cut Domain Family Member 2 3
  • Onecut 2 3
  • HNF6B 4
  • OC2 3

External Ids for ONECUT2 Gene

Previous GeneCards Identifiers for ONECUT2 Gene

  • GC18P055133
  • GC18P054887
  • GC18P053251
  • GC18P053253
  • GC18P055102
  • GC18P051813

Summaries for ONECUT2 Gene

Entrez Gene Summary for ONECUT2 Gene

  • This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ONECUT2 Gene

ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Diseases associated with ONECUT2 include Suppurative Thyroiditis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for ONECUT2 Gene

  • Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT2 Gene

Genomics for ONECUT2 Gene

Regulatory Elements for ONECUT2 Gene

Enhancers for ONECUT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G057426 1.6 FANTOM5 ENCODE dbSUPER 19.1 -4.7 -4673 8.7 PKNOX1 ZNF133 ARID4B FEZF1 YY1 GTF3C2 GLIS2 GATA2 CBX5 ZNF143 ONECUT2 ENSG00000277837
GH18G057437 1.5 FANTOM5 ENCODE dbSUPER 13.7 +4.9 4899 6.7 PKNOX1 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 GATA2 ZNF143 FOS ZNF263 ONECUT2 ST8SIA3 LOC105372139
GH18G057436 0.9 ENCODE dbSUPER 0.7 +1.1 1139 0.2 SCRT1 RNF2 SUZ12 ARID4B CHD1 CBX2 CBX8 ZNF366 SCRT2 ZNF600 ONECUT2 LOC105372139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ONECUT2 on UCSC Golden Path with GeneCards custom track

Promoters for ONECUT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103777 -85 801 PKNOX1 ZNF133 ARID4B GLIS2 FOS SP3 SP5 MXD4 NFYC REST

Genomic Location for ONECUT2 Gene

Chromosome:
18
Start:
57,435,685 bp from pter
End:
57,491,298 bp from pter
Size:
55,614 bases
Orientation:
Plus strand

Genomic View for ONECUT2 Gene

Genes around ONECUT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT2 Gene

Proteins for ONECUT2 Gene

  • Protein details for ONECUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95948-ONEC2_HUMAN
    Recommended name:
    One cut domain family member 2
    Protein Accession:
    O95948

    Protein attributes for ONECUT2 Gene

    Size:
    504 amino acids
    Molecular mass:
    54303 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB38253.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};

neXtProt entry for ONECUT2 Gene

Post-translational modifications for ONECUT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT2 Gene

Domains & Families for ONECUT2 Gene

Gene Families for ONECUT2 Gene

Protein Domains for ONECUT2 Gene

Suggested Antigen Peptide Sequences for ONECUT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95948

UniProtKB/Swiss-Prot:

ONEC2_HUMAN :
  • Belongs to the CUT homeobox family.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT2: view

Function for ONECUT2 Gene

Molecular function for ONECUT2 Gene

GENATLAS Biochemistry:
one cut domain, family member 2
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Gene Ontology (GO) - Molecular Function for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11478782
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 11478782
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ONECUT2: view
genes like me logo Genes that share phenotypes with ONECUT2: view

Animal Models for ONECUT2 Gene

MGI Knock Outs for ONECUT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ONECUT2 Gene

Localization for ONECUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ONECUT2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endoplasmic reticulum 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ONECUT2: view

Pathways & Interactions for ONECUT2 Gene

genes like me logo Genes that share pathways with ONECUT2: view

Pathways by source for ONECUT2 Gene

Interacting Proteins for ONECUT2 Gene

Selected Interacting proteins: O95948-ONEC2_HUMAN for ONECUT2 Gene via IID

Gene Ontology (GO) - Biological Process for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0002064 epithelial cell development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ONECUT2: view

No data available for SIGNOR curated interactions for ONECUT2 Gene

Drugs & Compounds for ONECUT2 Gene

No Compound Related Data Available

Transcripts for ONECUT2 Gene

mRNA/cDNA for ONECUT2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT2 Gene

One cut homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT2 Gene

No ASD Table

Relevant External Links for ONECUT2 Gene

GeneLoc Exon Structure for
ONECUT2
ECgene alternative splicing isoforms for
ONECUT2

Expression for ONECUT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ONECUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT2 Gene

This gene is overexpressed in Liver (x11.0), Brain - Putamen (basal ganglia) (x9.4), Brain - Caudate (basal ganglia) (x8.2), Brain - Nucleus accumbens (basal ganglia) (x7.0), and Pancreas (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ONECUT2 Gene:

ONECUT2

SOURCE GeneReport for Unigene cluster for ONECUT2 Gene:

Hs.194725
genes like me logo Genes that share expression patterns with ONECUT2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ONECUT2 Gene

Orthologs for ONECUT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ONECUT2 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia ONECUT2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ONECUT2 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ONECUT2 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ONECUT2 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Onecut2 34 16 35
  • 91.65 (n)
rat
(Rattus norvegicus)
Mammalia Onecut2 34
  • 90.87 (n)
chicken
(Gallus gallus)
Aves ONECUT2 34 35
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia ONECUT2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia onecut2 34
  • 80.54 (n)
zebrafish
(Danio rerio)
Actinopterygii ONECUT2 35
  • 80 (a)
OneToOne
si:ch1073-41k10.1 34
  • 78.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta onecut 36 35
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea C17H12.9 36
  • 80 (a)
ceh-38 36
  • 50 (a)
ceh-48 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for ONECUT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT2 Gene

ENSEMBL:
Gene Tree for ONECUT2 (if available)
TreeFam:
Gene Tree for ONECUT2 (if available)

Paralogs for ONECUT2 Gene

Paralogs for ONECUT2 Gene

(2) SIMAP similar genes for ONECUT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ONECUT2: view

Variants for ONECUT2 Gene

Sequence variations from dbSNP and Humsavar for ONECUT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000004692 -- 57,434,927(+) GTGAC(C/G)AGTGT upstream-variant-2KB
rs1000141172 -- 57,468,289(+) CTCAA(C/T)CTTGA intron-variant
rs1000216654 -- 57,459,836(+) TTATA(A/G)GCGTG intron-variant
rs1000238353 -- 57,484,371(+) TTGAA(C/T)GATTT utr-variant-3-prime
rs1000273246 -- 57,444,158(+) CACTT(A/C)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT2 Gene

Variant ID Type Subtype PubMed ID
dgv1614n106 CNV deletion 24896259
esv1478795 CNV insertion 17803354
esv3347167 CNV insertion 20981092
esv995991 CNV insertion 20482838
nsv1072806 CNV deletion 25765185
nsv476415 CNV novel sequence insertion 20440878
nsv476913 CNV novel sequence insertion 20440878
nsv828250 CNV gain 20364138
nsv953552 CNV deletion 24416366

Variation tolerance for ONECUT2 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ONECUT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ONECUT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ONECUT2 Gene

Disorders for ONECUT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ONECUT2

Genetic Association Database (GAD)
ONECUT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ONECUT2
genes like me logo Genes that share disorders with ONECUT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT2 Gene

Publications for ONECUT2 Gene

  1. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene. (PMID: 11478782) Jacquemin P. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2001) 3 22 64
  3. Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1. (PMID: 27756894) Ao R. … Wang B.F. (Med. Sci. Monit. 2016) 3 64
  4. Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. (PMID: 26547929) Zhang J. … Lu F. (Oncotarget 2015) 3 64
  5. MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma. (PMID: 24402783) Sun Y. … Wu M. (Mol. Cell. Biochem. 2014) 3 64

Products for ONECUT2 Gene

Sources for ONECUT2 Gene

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