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Aliases for ONECUT2 Gene

Aliases for ONECUT2 Gene

  • One Cut Homeobox 2 2 3 4
  • Hepatocyte Nuclear Factor 6-Beta 3 4
  • One Cut Domain, Family Member 2 2 3
  • Transcription Factor ONECUT-2 3 4
  • HNF-6-Beta 3 4
  • OC-2 3 4
  • OC2 3 6
  • ONECUT-2 Homeodomain Transcription Factor 3
  • One Cut Domain Family Member 2 3
  • Onecut 2 3
  • HNF6B 4

External Ids for ONECUT2 Gene

Summaries for ONECUT2 Gene

Entrez Gene Summary for ONECUT2 Gene

  • This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ONECUT2 Gene

ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Diseases associated with ONECUT2 include hemophilia b. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for ONECUT2 Gene

  • Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT2 Gene

Genomics for ONECUT2 Gene

Genomic Location for ONECUT2 Gene

Start:
57,435,685 bp from pter
End:
57,491,298 bp from pter
Size:
55,614 bases
Orientation:
Plus strand

Genomic View for ONECUT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ONECUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT2 Gene

Regulatory Elements for ONECUT2 Gene

Proteins for ONECUT2 Gene

  • Protein details for ONECUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95948-ONEC2_HUMAN
    Recommended name:
    One cut domain family member 2
    Protein Accession:
    O95948
    Secondary Accessions:

    Protein attributes for ONECUT2 Gene

    Size:
    504 amino acids
    Molecular mass:
    54303 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB38253.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};

neXtProt entry for ONECUT2 Gene

Proteomics data for ONECUT2 Gene at MOPED

Post-translational modifications for ONECUT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT2 Gene

Domains for ONECUT2 Gene

Gene Families for ONECUT2 Gene

HGNC:
  • CUT :Homeoboxes / CUT class

Protein Domains for ONECUT2 Gene

UniProtKB/Swiss-Prot:

ONEC2_HUMAN
Domain:
  • Contains 1 CUT DNA-binding domain.:
    • O95948
  • Contains 1 homeobox DNA-binding domain.:
    • O95948
Family:
  • Belongs to the CUT homeobox family.:
    • O95948
genes like me logo Genes that share domains with ONECUT2: view

Function for ONECUT2 Gene

Molecular function for ONECUT2 Gene

GENATLAS Biochemistry: one cut domain, family member 2
UniProtKB/Swiss-Prot Function: Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B

Gene Ontology (GO) - Molecular Function for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11478782
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 11478782
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ONECUT2: view

Phenotypes for ONECUT2 Gene

genes like me logo Genes that share phenotypes with ONECUT2: view

miRNA for ONECUT2 Gene

miRTarBase miRNAs that target ONECUT2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ONECUT2 Gene

Localization for ONECUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ONECUT2 Gene COMPARTMENTS Subcellular localization image for ONECUT2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ONECUT2: view

Pathways for ONECUT2 Gene

SuperPathways for ONECUT2 Gene

No Data Available

Interacting Proteins for ONECUT2 Gene

Selected Interacting proteins: O95948-ONEC2_HUMAN for ONECUT2 Gene via I2D

Symbol External ID(s) Details
KDM5B

Gene Ontology (GO) - Biological Process for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0002064 epithelial cell development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis --
genes like me logo Genes that share ontologies with ONECUT2: view

No data available for Pathways by source for ONECUT2 Gene

Transcripts for ONECUT2 Gene

mRNA/cDNA for ONECUT2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT2 Gene

One cut homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT2 Gene

No ASD Table

Relevant External Links for ONECUT2 Gene

GeneLoc Exon Structure for
ONECUT2
ECgene alternative splicing isoforms for
ONECUT2

Expression for ONECUT2 Gene

mRNA expression in normal human tissues for ONECUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT2 Gene

This gene is overexpressed in Liver (11.0), Brain - Putamen (basal ganglia) (9.4), Brain - Caudate (basal ganglia) (8.2), Brain - Nucleus accumbens (basal ganglia) (7.0), and Pancreas (4.5).

SOURCE GeneReport for Unigene cluster for ONECUT2 Gene Hs.194725

genes like me logo Genes that share expressions with ONECUT2: view

Orthologs for ONECUT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ONECUT2 36
  • 99.12 (n)
  • 99.47 (a)
ONECUT2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ONECUT2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ONECUT2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Onecut2 36
  • 91.65 (n)
  • 98.81 (a)
Onecut2 16
Onecut2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ONECUT2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ONECUT2 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Onecut2 36
  • 90.87 (n)
  • 98.32 (a)
chicken
(Gallus gallus)
Aves ONECUT2 36
  • 79.02 (n)
  • 77.46 (a)
ONECUT2 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ONECUT2 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia onecut2 36
  • 80.54 (n)
  • 86.93 (a)
zebrafish
(Danio rerio)
Actinopterygii ONECUT2 37
  • 80 (a)
OneToOne
si:ch1073-41k10.1 36
  • 78.34 (n)
  • 81.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta onecut 37
  • 20 (a)
OneToMany
onecut 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-48 37
  • 38 (a)
OneToMany
C17H12.9 38
  • 80 (a)
ceh-38 38
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for ONECUT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT2 Gene

ENSEMBL:
Gene Tree for ONECUT2 (if available)
TreeFam:
Gene Tree for ONECUT2 (if available)

Paralogs for ONECUT2 Gene

Paralogs for ONECUT2 Gene

Selected SIMAP similar genes for ONECUT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ONECUT2: view

Variants for ONECUT2 Gene

Sequence variations from dbSNP and Humsavar for ONECUT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs471382 -- 57,482,475(+) TCCTT(A/G)GAGGT utr-variant-3-prime
rs480302 -- 57,478,633(-) GCAGC(A/C)ACTGA utr-variant-3-prime
rs485401 -- 57,445,577(+) TTTAT(C/G)TGATT intron-variant
rs491165 -- 57,485,470(+) GTCTT(C/T)TTCAA utr-variant-3-prime
rs496194 -- 57,449,572(+) CGCCA(A/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT2 Gene

Variant ID Type Subtype PubMed ID
nsv828250 CNV Gain 20364138
esv995991 CNV Insertion 20482838
esv1478795 CNV Insertion 17803354

Relevant External Links for ONECUT2 Gene

HapMap Linkage Disequilibrium report
ONECUT2

Disorders for ONECUT2 Gene

(1) MalaCards Diseases for ONECUT2 Gene

Search for ONECUT2 Gene in MalaCards »

Relevant External Links for ONECUT2

Genetic Association Database (GAD)
ONECUT2
genes like me logo Genes that share disorders with ONECUT2: view

No data available for UniProtKB/Swiss-Prot for ONECUT2 Gene

Publications for ONECUT2 Gene

  1. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 3 4 23
  2. The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene. (PMID: 11478782) Jacquemin P. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2001) 3 23
  3. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. (PMID: 16103213) Clotman F. … Lemaigre F.P. (Genes Dev. 2005) 23
  4. Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. (PMID: 19800948) Francius C. … Clotman F. (Neuroscience 2010) 23
  5. MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2. (PMID: 19913497) Simion A. … Jacquemin P. (Biochem. Biophys. Res. Commun. 2010) 23

Products for ONECUT2 Gene

Sources for ONECUT2 Gene

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