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Aliases for ONECUT2 Gene

Aliases for ONECUT2 Gene

  • One Cut Homeobox 2 2 3 4 5
  • Hepatocyte Nuclear Factor 6-Beta 3 4
  • One Cut Domain, Family Member 2 2 3
  • Transcription Factor ONECUT-2 3 4
  • HNF-6-Beta 3 4
  • OC-2 3 4
  • ONECUT-2 Homeodomain Transcription Factor 3
  • Onecut 2 3
  • HNF6B 4
  • OC2 3

External Ids for ONECUT2 Gene

Previous GeneCards Identifiers for ONECUT2 Gene

  • GC18P055133
  • GC18P054887
  • GC18P053251
  • GC18P053253
  • GC18P055102
  • GC18P051813

Summaries for ONECUT2 Gene

Entrez Gene Summary for ONECUT2 Gene

  • This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ONECUT2 Gene

ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for ONECUT2 Gene

  • Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT2 Gene

Genomics for ONECUT2 Gene

Regulatory Elements for ONECUT2 Gene

Enhancers for ONECUT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ONECUT2 on UCSC Golden Path with GeneCards custom track

Promoters for ONECUT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ONECUT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ONECUT2 Gene

57,435,685 bp from pter
57,491,298 bp from pter
55,614 bases
Plus strand

Genomic View for ONECUT2 Gene

Genes around ONECUT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT2 Gene

Proteins for ONECUT2 Gene

  • Protein details for ONECUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    One cut domain family member 2
    Protein Accession:

    Protein attributes for ONECUT2 Gene

    504 amino acids
    Molecular mass:
    54303 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB38253.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};

neXtProt entry for ONECUT2 Gene

Proteomics data for ONECUT2 Gene at MOPED

Post-translational modifications for ONECUT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ONECUT2 (ONECUT2/OC-2)

No data available for DME Specific Peptides for ONECUT2 Gene

Domains & Families for ONECUT2 Gene

Gene Families for ONECUT2 Gene

Protein Domains for ONECUT2 Gene

Suggested Antigen Peptide Sequences for ONECUT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUT DNA-binding domain.
  • Belongs to the CUT homeobox family.
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT2: view

Function for ONECUT2 Gene

Molecular function for ONECUT2 Gene

GENATLAS Biochemistry:
one cut domain, family member 2
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
genes like me logo Genes that share phenotypes with ONECUT2: view

Animal Models for ONECUT2 Gene

MGI Knock Outs for ONECUT2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ONECUT2 Gene

Localization for ONECUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT2 Gene

Subcellular locations from

Jensen Localization Image for ONECUT2 Gene COMPARTMENTS Subcellular localization image for ONECUT2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ONECUT2: view

Pathways & Interactions for ONECUT2 Gene

genes like me logo Genes that share pathways with ONECUT2: view

Pathways by source for ONECUT2 Gene

Interacting Proteins for ONECUT2 Gene

Selected Interacting proteins: O95948-ONEC2_HUMAN for ONECUT2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002064 epithelial cell development IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 11478782
GO:0009653 anatomical structure morphogenesis IEA --
GO:0009887 organ morphogenesis TAS 9915796
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with ONECUT2: view

No data available for SIGNOR curated interactions for ONECUT2 Gene

Drugs & Compounds for ONECUT2 Gene

No Compound Related Data Available

Transcripts for ONECUT2 Gene

mRNA/cDNA for ONECUT2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT2 Gene

One cut homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT2 Gene

No ASD Table

Relevant External Links for ONECUT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ONECUT2 Gene

mRNA expression in normal human tissues for ONECUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT2 Gene

This gene is overexpressed in Liver (x11.0), Brain - Putamen (basal ganglia) (x9.4), Brain - Caudate (basal ganglia) (x8.2), Brain - Nucleus accumbens (basal ganglia) (x7.0), and Pancreas (x4.5).

SOURCE GeneReport for Unigene cluster for ONECUT2 Gene Hs.194725

genes like me logo Genes that share expression patterns with ONECUT2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ONECUT2 Gene

Orthologs for ONECUT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Onecut2 35
  • 91.65 (n)
  • 98.81 (a)
Onecut2 16
Onecut2 36
  • 99 (a)
(Pan troglodytes)
Mammalia ONECUT2 35
  • 99.12 (n)
  • 99.47 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Onecut2 35
  • 90.87 (n)
  • 98.32 (a)
(Bos Taurus)
Mammalia ONECUT2 36
  • 94 (a)
(Canis familiaris)
Mammalia ONECUT2 36
  • 98 (a)
(Monodelphis domestica)
Mammalia ONECUT2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ONECUT2 36
  • 92 (a)
(Gallus gallus)
Aves ONECUT2 35
  • 79.02 (n)
  • 77.46 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia ONECUT2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia onecut2 35
  • 80.54 (n)
  • 86.93 (a)
(Danio rerio)
Actinopterygii si:ch1073-41k10.1 35
  • 78.34 (n)
  • 81.82 (a)
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta onecut 37
  • 59 (a)
onecut 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C17H12.9 37
  • 80 (a)
ceh-38 37
  • 50 (a)
ceh-48 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for ONECUT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT2 Gene

Gene Tree for ONECUT2 (if available)
Gene Tree for ONECUT2 (if available)

Paralogs for ONECUT2 Gene

Paralogs for ONECUT2 Gene

(2) SIMAP similar genes for ONECUT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ONECUT2: view

Variants for ONECUT2 Gene

Sequence variations from dbSNP and Humsavar for ONECUT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7231349 -- 57,440,793(+) CGCGC(C/T)CACCC intron-variant
rs7231354 -- 57,440,796(+) GCCCA(A/C)CCCCC intron-variant
rs471382 -- 57,482,475(+) TCCTT(A/G)GAGGT utr-variant-3-prime
rs480302 -- 57,478,633(-) GCAGC(A/C)ACTGA utr-variant-3-prime
rs7232930 -- 57,437,618(+) CTTGA(A/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT2 Gene

Variant ID Type Subtype PubMed ID
nsv828250 CNV Gain 20364138
esv995991 CNV Insertion 20482838
esv1478795 CNV Insertion 17803354

Variation tolerance for ONECUT2 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ONECUT2 Gene

Disorders for ONECUT2 Gene

Relevant External Links for ONECUT2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ONECUT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ONECUT2 Gene

Publications for ONECUT2 Gene

  1. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene. (PMID: 11478782) Jacquemin P. … Rousseau G.G. (Biochem. Biophys. Res. Commun. 2001) 3 23
  3. MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma. (PMID: 24402783) Sun Y. … Wu M. (Mol. Cell. Biochem. 2014) 3
  4. A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. (PMID: 23472758) Funnell A.P. … Crossley M. (Am. J. Hum. Genet. 2013) 3
  5. Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. (PMID: 19800948) Francius C. … Clotman F. (Neuroscience 2010) 23

Products for ONECUT2 Gene

Sources for ONECUT2 Gene