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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ONECUT1 Gene

protein-coding   GIFtS: 56
GCID: GC15M053049

One Cut Homeobox 1

(Previous names: one cut domain, family member 1)
(Previous symbols: HNF6, HNF6A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
One Cut Homeobox 11 2 3     HNF-62 3
HNF61 2 3 5     One Cut Domain, Family Member 11
HNF6A1 2 3 5     Hepatocyte Nuclear Factor 62
One Cut Domain Family Member 12 3     Hepatocyte Nuclear Factor 6, Alpha2

External Ids:    HGNC: 81381   Entrez Gene: 31752   Ensembl: ENSG000001698567   OMIM: 6041645   UniProtKB: Q9UBC03   

Export aliases for ONECUT1 gene to outside databases

Previous GC identifers: GC15M048607 GC15M046096 GC15M050628 GC15M050765 GC15M050836 GC15M029879


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ONECUT1 Gene:
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein
is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes
glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including
glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for ONECUT1 Gene: 
ONECUT1 (one cut homeobox 1) is a protein-coding gene. Diseases associated with ONECUT1 include intestinal atresia, and protein c deficiency, and among its related super-pathways are Regulation of beta-cell development and Axon guidance. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CUX2.

UniProtKB/Swiss-Prot: HNF6_HUMAN, Q9UBC0
Function: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
promoters such as those of HNF3B and TTR. Important for liver genes transcription




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ONECUT1 gene promoter:
         TBP   NF-1   NF-1/L   E2F   p300   NRSF form 1   CUTL1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidONECUT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ONECUT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ONECUT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

ONECUT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ONECUT1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M053049:  view genomic region     (about GC identifiers)

Start:
53,049,353 bp from pter      End:
53,083,273 bp from pter
Size:
33,921 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HNF6_HUMAN, Q9UBC0 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 6  
Size: 465 amino acids; 51023 Da
Subunit: Binds DNA as a monomer (By similarity)
Subcellular location: Nucleus
Secondary accessions: B2RTV4 Q99744 Q9UMR6

Explore the universe of human proteins at neXtProt for ONECUT1: NX_Q9UBC0

Explore proteomics data for ONECUT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBC0

  • ONECUT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ONECUT1 Protein Expression
    REFSEQ proteins: NP_004489.1  
    ENSEMBL proteins: 
     ENSP00000453718   ENSP00000302630   ENSP00000476168  
    Reactome Protein details: Q9UBC0
    Human Recombinant Protein Products for ONECUT1: 
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    Novus Biologicals ONECUT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    ONECUT1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CUT: Homeoboxes / CUT class

    4 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UBC0

    ProtoNet protein and cluster: Q9UBC0

    1 Blocks protein domain: IPB003350 Homeodomain protein CUT

    UniProtKB/Swiss-Prot: HNF6_HUMAN, Q9UBC0
    Similarity: Belongs to the CUT homeobox family
    Similarity: Contains 1 CUT DNA-binding domain
    Similarity: Contains 1 homeobox DNA-binding domain


    ONECUT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HNF6_HUMAN, Q9UBC0
    Function: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene
    promoters such as those of HNF3B and TTR. Important for liver genes transcription

         Genatlas biochemistry entry for ONECUT1:
    one cut domain, family member 1,with a novel type of homeo domain,expressed in pancreatic beta cells,inhibiting
    the glucocorticoid-induced stimulation of two genes of the glucose metabolism,6-phosphofructo-2-kinase (PFKFB1)
    and PEPCK (PCK1,PCK2) via its interaction with the glucocorticoid reponse unit GRU of these genes,in cooperation
    with GRL,not mutated in NIDDM

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding IEA--
         
    ONECUT1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Onecut1):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging 

    ONECUT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Onecut1tm1Flem for ONECUT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ONECUT1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ONECUT1 
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    SwitchGear 3'UTR luciferase reporter plasmidONECUT1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ONECUT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.56
    Maturity onset diabetes of the young0.56
    2Axon guidance
    Developmental Biology0.69
    3Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    4Regulation of gene expression in early pancreatic precursor cells
    Regulation of gene expression in early pancreatic precursor cells
    5FOXM1 transcription factor network
    FOXM1 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ONECUT1
        Transcriptional Regulatory Network in Embryonic Stem Cell

    1 BioSystems Pathway for ONECUT1
        FOXM1 transcription factor network

    3        Reactome Pathways for ONECUT1
        Developmental Biology
    Regulation of beta-cell development
    Regulation of gene expression in early pancreatic precursor cells


    1         Kegg Pathway  (Kegg details for ONECUT1):
        Maturity onset diabetes of the young


    ONECUT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ONECUT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for ONECUT1 (Q9UBC03 ENSP000003026304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    FOXA1P553173, ENSP000002504484I2D: score=1 STRING: ENSP00000250448
    FOXA2Q9Y2613, ENSP000003159554I2D: score=2 STRING: ENSP00000315955
    KAT2BQ928313, ENSP000002637544I2D: score=2 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0001952regulation of cell-matrix adhesion IEA--
    GO:0002064epithelial cell development IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS10491763

    ONECUT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ONECUT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ONECUT1 (HNF6)

    2 Novoseek inferred chemical compound relationships for ONECUT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 30.9 15 10491763 (2), 18459945 (2), 16079311 (1), 10992877 (1) (see all 8)
    glycogen 8.6 2 11915024 (2)

    Search CenterWatch for drugs/clinical trials and news about ONECUT1 / HNF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ONECUT1 gene: 
    NM_004498.2  

    Unigene Cluster for ONECUT1:

    One cut homeobox 1
    Hs.658573  [show with all ESTs]
    Unigene Representative Sequence: NM_004498
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560699 ENST00000305901(uc002aci.1) ENST00000561401 ENST00000570208

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    hsa-miR-3671 hsa-miR-320a hsa-miR-607 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-320d hsa-miR-3692 hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidONECUT1 3' UTR sequence
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    Additional mRNA sequence: 

    BC140830.1 EU532019.1 NR_073510.1 U77975.1 U96173.1 

    2 DOTS entries:

    DT.306074  DT.75175931 

    6 AceView cDNA sequences:

    NM_004498 AA706793 U96173 AA699732 U77975 BG111077 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ONECUT1 expression in normal human tissues (normalized intensities)      ONECUT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAGAAC
    ONECUT1 Expression
    About this image


    ONECUT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 21 entries
             Duct Cells Pancreatic Ducts
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             visceral organ/gut/foregut-midgut junction   
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Medulla Oblongata
             brain/forebrain/diencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
             brain/forebrain/diencephalon   
     
     Liver (Hepatobiliary System)    fully expand to see all 5 entries
             Immature Biliary Epithelial Cells Intrahepatic Biliary Tree
             Hepatocyte-like cells ( Functional hepatocyte generation from human embryonic stem...
             visceral organ/common bile duct   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 4 entries
             Hepatic Endoderm Cells Ventral Foregut Endoderm

    See ONECUT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ONECUT1

    SOURCE GeneReport for Unigene cluster: Hs.658573

    UniProtKB/Swiss-Prot: HNF6_HUMAN, Q9UBC0
    Tissue specificity: Highly expressed in liver; lower expression in testis and skin

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ONECUT1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Onecut11 , 5 one cut domain, family member 11, 5 93.84(n)1
    98.92(a)1
      9 (41.93 cM)5
    153791  NM_008262.31  NP_032288.11 
     748619215 
    chicken
    (Gallus gallus)
    Aves LOC1008573121 one cut domain family member 2-like 73.66(n)
    72.12(a)
      100857312  XM_003642857.1  XP_003642905.1 
    lizard
    (Anolis carolinensis)
    Reptilia ONECUT36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343862.1(103045-134149)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659042 hypothetical protein MGC65904 80.65(n)   393545  BC056601.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta onecut3 regulation of transcription,
    DNA-dependent RNA more
    85(a)   102C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-486
    ceh-386
    Homeobox protein ceh-38
    36(a)
    19(a)
    1 ↔ many
    possible ortholog
    IV(6812106-6815581)
    II(6951640-6955408)


    ENSEMBL Gene Tree for ONECUT1 (if available)
    TreeFam Gene Tree for ONECUT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ONECUT1 gene
    CUX22  ONECUT22  ONECUT32  CUX12  
    2 SIMAP similar genes for ONECUT1 using alignment to 3 protein entries:     HNF6_HUMAN (see all proteins):
    ONECUT2    ONECUT3

    ONECUT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/763 SNPs in ONECUT1 are shown (see all 763)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916548001,2
    --53048884(+) GAAAAC/GTCATA 2 -- ds50010--------
    rs1150578151,2
    F--53049001(+) AATAGC/TTTTGG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs24403331,2
    C,F,A,H--53049094(-) AAACAA/TGAGTC 2 -- ds500130Minor allele frequency- T:0.18NA NS EA WA CSA 2710
    rs1852731121,2
    --53049195(+) TCTGCA/CTTTAG 2 -- ut31 nc-transcript-variant0--------
    rs1456054731,2
    --53049224(+) TCAAAC/TGTTAG 2 -- ut31 nc-transcript-variant0--------
    rs1489115831,2
    --53049225(+) CAAACG/TTTAGG 2 -- ut31 nc-transcript-variant0--------
    rs1426116851,2
    C--53049372(+) GACACA/CATACA 2 -- ut31 nc-transcript-variant0--------
    rs1509959101,2
    C--53049374(+) CACCAC/TACACC 2 -- ut31 nc-transcript-variant0--------
    rs1421720401,2
    --53049383(+) CCTTCA/GTGGCA 2 -- ut31 nc-transcript-variant0--------
    rs1458282231,2
    --53049481(+) CACAGC/TGAGGA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ONECUT1 (53049353 - 53083273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ONECUT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471245CNV Gain18288195
    nsv457142CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604164    OMIM disorders: --

    13 diseases for ONECUT1:    About MalaCards
    intestinal atresia    protein c deficiency    neonatal diabetes mellitus    maturity-onset diabetes of the young
    cholestasis    diabetes mellitus    cytochrome p450    liver disease
    pancreatic cancer    pancreatitis    hepatocellular carcinoma    hepatitis
    neuronitis


    ONECUT1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ONECUT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenovirus infections 50 1 11915024 (1)
    niddm 38.5 5 10491763 (2), 18058600 (1)

    Genetic Association Database (GAD): ONECUT1

    Export disorders for ONECUT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ONECUT1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with ONECUT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. (PubMed id 10491763)1, 2, 9 Moeller A.M.... Pedersen O. (1999)
    2. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. (PubMed id 8887657)1, 3 Samadani U. and Costa R.H. (1996)
    3. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. (PubMed id 8790352)1, 3 Lemaigre F.P....Rousseau G.G. (1996)
    4. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. (PubMed id 12509444)1, 9 Rausa F.M....Costa R.H. (2003)
    5. Loss of ONECUT1 expression in human pancreatic cancer cells. (PubMed id 18097590)1, 9 Jiang X....Kleeff J. (2008)
    6. Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation. (PubMed id 18459945)1, 9 Lee Y.S....Choi H.S. (2008)
    7. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. (PubMed id 17283222)1, 9 Lehner F....Borlak J. (2007)
    8. Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. (PubMed id 15304484)1, 9 Rausa F.M....Costa R.H. (2004)
    9. Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). (PubMed id 10811635)1, 9 Lannoy V.J....Lemaigre F.P. (2000)
    10. Antiglucocorticoid activity of hepatocyte nuclear factor-6. (PubMed id 10430878)1, 9 Pierreux C.E....Lemaigre F.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3175 HGNC: 8138 AceView: ONECUT1 Ensembl:ENSG00000169856 euGenes: HUgn3175
    ECgene: ONECUT1 Kegg: 3175 H-InvDB: ONECUT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ONECUT1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ONECUT1 gene:
    Search GeneIP for patents involving ONECUT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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