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Aliases for ONECUT1 Gene

Aliases for ONECUT1 Gene

  • One Cut Homeobox 1 2 3 4 5
  • One Cut Domain Family Member 1 3 4
  • HNF6A 3 4
  • HNF-6 3 4
  • HNF6 3 4
  • Hepatocyte Nuclear Factor 6, Alpha 3
  • One Cut Domain, Family Member 1 2

External Ids for ONECUT1 Gene

Previous HGNC Symbols for ONECUT1 Gene

  • HNF6
  • HNF6A

Previous GeneCards Identifiers for ONECUT1 Gene

  • GC15M048607
  • GC15M046096
  • GC15M050628
  • GC15M050765
  • GC15M050836
  • GC15M053049
  • GC15M029879

Summaries for ONECUT1 Gene

Entrez Gene Summary for ONECUT1 Gene

  • This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for ONECUT1 Gene

ONECUT1 (One Cut Homeobox 1) is a Protein Coding gene. Diseases associated with ONECUT1 include Maturity-Onset Diabetes Of The Young and Pharyngoconjunctival Fever. Among its related pathways are FOXM1 transcription factor network and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ONECUT3.

UniProtKB/Swiss-Prot for ONECUT1 Gene

  • Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT1 Gene

Genomics for ONECUT1 Gene

Regulatory Elements for ONECUT1 Gene

Enhancers for ONECUT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ONECUT1 on UCSC Golden Path with GeneCards custom track

Promoters for ONECUT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ONECUT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ONECUT1 Gene

52,756,963 bp from pter
52,791,078 bp from pter
34,116 bases
Minus strand

Genomic View for ONECUT1 Gene

Genes around ONECUT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT1 Gene

Proteins for ONECUT1 Gene

  • Protein details for ONECUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte nuclear factor 6
    Protein Accession:
    Secondary Accessions:
    • B2RTV4
    • Q99744
    • Q9UMR6

    Protein attributes for ONECUT1 Gene

    465 amino acids
    Molecular mass:
    51023 Da
    Quaternary structure:
    • Binds DNA as a monomer.

neXtProt entry for ONECUT1 Gene

Proteomics data for ONECUT1 Gene at MOPED

Post-translational modifications for ONECUT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ONECUT1 (HNF-6/ONECUT1)

No data available for DME Specific Peptides for ONECUT1 Gene

Domains & Families for ONECUT1 Gene

Gene Families for ONECUT1 Gene

Protein Domains for ONECUT1 Gene

Suggested Antigen Peptide Sequences for ONECUT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUT DNA-binding domain.
  • Belongs to the CUT homeobox family.
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT1: view

Function for ONECUT1 Gene

Molecular function for ONECUT1 Gene

GENATLAS Biochemistry:
one cut domain, family member 1,with a novel type of homeo domain,expressed in pancreatic beta cells,inhibiting the glucocorticoid-induced stimulation of two genes of the glucose metabolism,6-phosphofructo-2-kinase (PFKFB1) and PEPCK (PCK1,PCK2) via its interaction with the glucocorticoid reponse unit GRU of these genes,in cooperation with GRL,not mutated in NIDDM
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
genes like me logo Genes that share phenotypes with ONECUT1: view

Animal Models for ONECUT1 Gene

MGI Knock Outs for ONECUT1:

Animal Model Products

CRISPR Products

Targeted motifs for ONECUT1 Gene
HOMER Transcription Factor Regulatory Elements motif ONECUT1
  • Consensus sequence: NTATYGATCH Submotif: canonical Cell Type: Liver GEO ID: ERP000394

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and Transcription Factor Targets for ONECUT1 Gene

Localization for ONECUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT1 Gene

Subcellular locations from

Jensen Localization Image for ONECUT1 Gene COMPARTMENTS Subcellular localization image for ONECUT1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ONECUT1 Gene

Pathways & Interactions for ONECUT1 Gene

genes like me logo Genes that share pathways with ONECUT1: view

Gene Ontology (GO) - Biological Process for ONECUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0002064 epithelial cell development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10491763
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ONECUT1: view

No data available for SIGNOR curated interactions for ONECUT1 Gene

Drugs & Compounds for ONECUT1 Gene

(2) Additional Compounds for ONECUT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ONECUT1: view

Transcripts for ONECUT1 Gene

mRNA/cDNA for ONECUT1 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT1 Gene

One cut homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT1 Gene

No ASD Table

Relevant External Links for ONECUT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ONECUT1 Gene

mRNA expression in normal human tissues for ONECUT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT1 Gene

This gene is overexpressed in Liver (x23.1), Pancreas (x20.8), and Testis (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ONECUT1 Gene

SOURCE GeneReport for Unigene cluster for ONECUT1 Gene Hs.658573

mRNA Expression by UniProt/SwissProt for ONECUT1 Gene

Tissue specificity: Highly expressed in liver; lower expression in testis and skin.
genes like me logo Genes that share expression patterns with ONECUT1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for ONECUT1 Gene

Orthologs for ONECUT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ONECUT1 35
  • 95.91 (n)
  • 98.92 (a)
  • 99 (a)
(Canis familiaris)
Mammalia ONECUT1 35
  • 96.56 (n)
  • 99.35 (a)
  • 99 (a)
(Mus musculus)
Mammalia Onecut1 35
  • 93.84 (n)
  • 98.92 (a)
Onecut1 16
Onecut1 36
  • 99 (a)
(Pan troglodytes)
Mammalia ONECUT1 35
  • 99.5 (n)
  • 99.35 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Onecut1 35
  • 93.98 (n)
  • 99.14 (a)
(Monodelphis domestica)
Mammalia ONECUT1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia ONECUT1 36
  • 100 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia onecut1 35
  • 78.7 (n)
  • 87.53 (a)
(Danio rerio)
Actinopterygii onecut1 35
  • 76.7 (n)
  • 83.63 (a)
zgc65904 35
onecut1 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta onecut 37
  • 85 (a)
onecut 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea ceh-48 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for ONECUT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT1 Gene

Gene Tree for ONECUT1 (if available)
Gene Tree for ONECUT1 (if available)

Paralogs for ONECUT1 Gene

Paralogs for ONECUT1 Gene

(2) SIMAP similar genes for ONECUT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ONECUT1: view

Variants for ONECUT1 Gene

Sequence variations from dbSNP and Humsavar for ONECUT1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_010729 -
rs1357 -- 52,778,803(-) TGTAT(C/T)TATCC intron-variant
rs2460 -- 52,780,887(+) ATCCC(A/G)TGGCG intron-variant, upstream-variant-2KB
rs5812628 -- 52,759,789(+) TTTTT(-/T)ATAGA intron-variant
rs5812629 -- 52,765,578(+) GCAGT(-/G/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT1 Gene

Variant ID Type Subtype PubMed ID
nsv471245 CNV Gain 18288195
nsv457142 CNV Gain 19166990

Variation tolerance for ONECUT1 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ONECUT1 Gene

Disorders for ONECUT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ONECUT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mason-type diabetes
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ONECUT1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ONECUT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT1 Gene

Publications for ONECUT1 Gene

  1. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. (PMID: 10491763) Moeller A.M. … Pedersen O. (Diabetologia 1999) 3 4 23 67
  2. Loss of ONECUT1 expression in human pancreatic cancer cells. (PMID: 18097590) Jiang X. … Kleeff J. (Oncol. Rep. 2008) 3 23
  3. Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation. (PMID: 18459945) Lee Y.S. … Choi H.S. (Biochem. J. 2008) 3 23
  4. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. (PMID: 17283222) Lehner F. … Borlak J. (FASEB J. 2007) 3 23
  5. Control of pancreas and liver gene expression by HNF transcription factors. (PMID: 14988562) Odom D.T. … Young R.A. (Science 2004) 3 23

Products for ONECUT1 Gene

Sources for ONECUT1 Gene