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Aliases for ONECUT1 Gene

Aliases for ONECUT1 Gene

  • One Cut Homeobox 1 2 3 4
  • HNF6A 3 4 6
  • HNF6 3 4 6
  • One Cut Domain Family Member 1 3 4
  • HNF-6 3 4
  • Hepatocyte Nuclear Factor 6, Alpha 3
  • One Cut Domain, Family Member 1 2
  • Hepatocyte Nuclear Factor 6 3

External Ids for ONECUT1 Gene

Previous HGNC Symbols for ONECUT1 Gene

  • HNF6
  • HNF6A

Previous GeneCards Identifiers for ONECUT1 Gene

  • GC15M048607
  • GC15M046096
  • GC15M050628
  • GC15M050765
  • GC15M050836
  • GC15M053049
  • GC15M029879

Summaries for ONECUT1 Gene

Entrez Gene Summary for ONECUT1 Gene

  • This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for ONECUT1 Gene

ONECUT1 (One Cut Homeobox 1) is a Protein Coding gene. Diseases associated with ONECUT1 include hemophilia b and intestinal atresia. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is ONECUT3.

UniProtKB/Swiss-Prot for ONECUT1 Gene

  • Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ONECUT1 Gene

Genomics for ONECUT1 Gene

Regulatory Elements for ONECUT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ONECUT1 Gene

Start:
52,756,963 bp from pter
End:
52,791,078 bp from pter
Size:
34,116 bases
Orientation:
Minus strand

Genomic View for ONECUT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ONECUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT1 Gene

Proteins for ONECUT1 Gene

  • Protein details for ONECUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBC0-HNF6_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 6
    Protein Accession:
    Q9UBC0
    Secondary Accessions:
    • B2RTV4
    • Q99744
    • Q9UMR6

    Protein attributes for ONECUT1 Gene

    Size:
    465 amino acids
    Molecular mass:
    51023 Da
    Quaternary structure:
    • Binds DNA as a monomer.

neXtProt entry for ONECUT1 Gene

Proteomics data for ONECUT1 Gene at MOPED

Post-translational modifications for ONECUT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ONECUT1 (HNF-6/ONECUT1)

No data available for DME Specific Peptides for ONECUT1 Gene

Domains for ONECUT1 Gene

Gene Families for ONECUT1 Gene

HGNC:
  • CUT :Homeoboxes / CUT class

Protein Domains for ONECUT1 Gene

Suggested Antigen Peptide Sequences for ONECUT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBC0

UniProtKB/Swiss-Prot:

HNF6_HUMAN :
  • Q9UBC0
Domain:
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT1: view

Function for ONECUT1 Gene

Molecular function for ONECUT1 Gene

GENATLAS Biochemistry:
one cut domain, family member 1,with a novel type of homeo domain,expressed in pancreatic beta cells,inhibiting the glucocorticoid-induced stimulation of two genes of the glucose metabolism,6-phosphofructo-2-kinase (PFKFB1) and PEPCK (PCK1,PCK2) via its interaction with the glucocorticoid reponse unit GRU of these genes,in cooperation with GRL,not mutated in NIDDM
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription

Gene Ontology (GO) - Molecular Function for ONECUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS --
GO:0003677 DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ONECUT1: view
genes like me logo Genes that share phenotypes with ONECUT1: view

Animal Models for ONECUT1 Gene

MGI Knock Outs for ONECUT1:

Animal Model Products

CRISPR Products

Targeting motifs for ONECUT1 Gene
HOMER Transcription Factor Regulatory Elements motif ONECUT1
  • Consensus sequence: NTATYGATCH Submotif: canonical Cell Type: Liver GeoId: ERP000394

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ONECUT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA and Transcription Factor Targeting for ONECUT1 Gene

Localization for ONECUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ONECUT1 Gene COMPARTMENTS Subcellular localization image for ONECUT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ONECUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ONECUT1: view

Pathways for ONECUT1 Gene

genes like me logo Genes that share pathways with ONECUT1: view

Gene Ontology (GO) - Biological Process for ONECUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0002064 epithelial cell development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ONECUT1: view

Compounds for ONECUT1 Gene

(2) Novoseek inferred chemical compound relationships for ONECUT1 Gene

Compound -log(P) Hits PubMed IDs
glucose 30.9 10
glycogen 8.6 2
genes like me logo Genes that share compounds with ONECUT1: view

Transcripts for ONECUT1 Gene

mRNA/cDNA for ONECUT1 Gene

(5) Additional mRNA sequences :
(7) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ONECUT1 Gene

One cut homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ONECUT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT1 Gene

No ASD Table

Relevant External Links for ONECUT1 Gene

GeneLoc Exon Structure for
ONECUT1
ECgene alternative splicing isoforms for
ONECUT1

Expression for ONECUT1 Gene

mRNA expression in normal human tissues for ONECUT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT1 Gene

This gene is overexpressed in Liver (23.1), Pancreas (20.8), and Testis (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ONECUT1 Gene

SOURCE GeneReport for Unigene cluster for ONECUT1 Gene Hs.658573

mRNA Expression by UniProt/SwissProt for ONECUT1 Gene

Q9UBC0-HNF6_HUMAN
Tissue specificity: Highly expressed in liver; lower expression in testis and skin
genes like me logo Genes that share expressions with ONECUT1: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for ONECUT1 Gene

Orthologs for ONECUT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ONECUT1 35
  • 95.91 (n)
  • 98.92 (a)
ONECUT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ONECUT1 35
  • 96.56 (n)
  • 99.35 (a)
ONECUT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Onecut1 35
  • 93.84 (n)
  • 98.92 (a)
Onecut1 16
Onecut1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ONECUT1 35
  • 99.5 (n)
  • 99.35 (a)
ONECUT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Onecut1 35
  • 93.98 (n)
  • 99.14 (a)
oppossum
(Monodelphis domestica)
Mammalia ONECUT1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ONECUT1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia onecut1 35
  • 78.7 (n)
  • 87.53 (a)
zebrafish
(Danio rerio)
Actinopterygii onecut1 35
  • 76.7 (n)
  • 83.63 (a)
zgc65904 35
onecut1 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta onecut 37
  • 85 (a)
onecut 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-48 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ONECUT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT1 Gene

ENSEMBL:
Gene Tree for ONECUT1 (if available)
TreeFam:
Gene Tree for ONECUT1 (if available)

Paralogs for ONECUT1 Gene

Paralogs for ONECUT1 Gene

Selected SIMAP similar genes for ONECUT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ONECUT1: view

Variants for ONECUT1 Gene

Sequence variations from dbSNP and Humsavar for ONECUT1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1357 -- 52,778,803(-) TGTAT(C/T)TATCC intron-variant
rs2460 -- 52,780,887(+) ATCCC(A/G)TGGCG intron-variant, upstream-variant-2KB
rs935191 -- 52,764,817(-) CTGCA(G/T)GCTAC intron-variant
rs1048965 -- 52,757,321(-) AAACA(C/T)CACTG utr-variant-3-prime, nc-transcript-variant
rs1048966 -- 52,757,320(-) AACAC(C/T)ACTGG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT1 Gene

Variant ID Type Subtype PubMed ID
nsv471245 CNV Gain 18288195
nsv457142 CNV Gain 19166990

Relevant External Links for ONECUT1 Gene

HapMap Linkage Disequilibrium report
ONECUT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ONECUT1 Gene

Disorders for ONECUT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ONECUT1 Gene in MalaCards »

(2) Diseases for ONECUT1 Gene including...

(2) Novoseek inferred disease relationships for ONECUT1 Gene

Disease -log(P) Hits PubMed IDs
adenovirus infections 50 1
niddm 38.5 3

Relevant External Links for ONECUT1

Genetic Association Database (GAD)
ONECUT1
genes like me logo Genes that share disorders with ONECUT1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ONECUT1 Gene

Publications for ONECUT1 Gene

  1. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. (PMID: 10491763) Moeller A.M. … Pedersen O. (Diabetologia 1999) 3 4 23
  2. Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus. (PMID: 11323086) Zhu Q. … Matsuzawa Y. (Diabetes Res. Clin. Pract. 2001) 23 48
  3. Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). (PMID: 10811635) Lannoy V.J. … Lemaigre F.P. (J. Biol. Chem. 2000) 3 23
  4. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. (PMID: 9231664) Vaisse C. … Stoffel M. (Diabetes 1997) 3 23
  5. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P. … Lemaigre F.P. (J. Biol. Chem. 1999) 3 23

Products for ONECUT1 Gene

Sources for ONECUT1 Gene

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