ONECUT1 Gene

Aliases
for ONECUT1 gene

Previous GC identifers: GC15M048607 GC15M046096 GC15M050628 GC15M050765 GC15M050836 GC15M029879

Summaries
for ONECUT1 gene

Genomic Views
for ONECUT1 gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010194.17  

SwitchGear Promoter luciferase reporter plasmid: ONECUT1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ONECUT1

ONECUT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M053049:  view genomic region     (about GC identifiers)

Proteins
for ONECUT1 gene

Explore the universe of human proteins at neXtProt for ONECUT1: NX_Q9UBC0

Post-translational modifications:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ONECUT1 OriGene Custom Protein Services for ONECUT1
	GenScript Custom Purified and Recombinant Proteins Services for ONECUT1
	Novus Biologicals ONECUT1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for ONECUT1 (HNF-6/ONECUT1)
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	Novus Biologicals ONECUT1 Antibodies
	Search for Antibodies for ONECUT1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ONECUT1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for ONECUT1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for ONECUT1 gene

ProtoNet protein and cluster: Q9UBC0

Function
for ONECUT1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ONECUT1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ONECUT1 (see all 13):
		hsa-miR-3671 hsa-miR-320a hsa-miR-607 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-320d hsa-miR-3692 hsa-miR-659
		SwitchGear 3'UTR luciferase reporter plasmid: ONECUT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ONECUT1 (see all 7) OriGene shRNA RFP: ONECUT1 OriGene siRNA: ONECUT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ONECUT1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ONECUT1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ONECUT1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ONECUT1 (NM_004498)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ONECUT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ONECUT1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ONECUT1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ONECUT1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Onecut1)

Pathways & Interactions
for ONECUT1 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of beta-cell development	Regulation of beta-cell development 1.00 Maturity onset diabetes of the young 0.56
2	Regulation of gene expression in early pancreatic precursor cells	Regulation of gene expression in early pancreatic precursor cells 1.00
3	HNF1B-dependent synthesis of HNF6 protein	HNF1B-dependent synthesis of HNF6 protein 1.00
4	Transcriptional Regulatory Network in Embryonic Stem Cell	Transcriptional Regulatory Network in Embryonic Stem Cell 1.00
5	FOXM1 transcription factor network	FOXM1 transcription factor network 1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ONECUT1

Transcriptional Regulatory Network in Embryonic Stem Cell

1 BioSystems Pathway for ONECUT1

FOXM1 transcription factor network

4        Reactome Pathways for ONECUT1

	Developmental Biology
	Regulation of beta-cell development
	HNF1B-dependent synthesis of HNF6 protein
	Regulation of gene expression in early pancreatic precursor cells

1         Kegg Pathway  (Kegg details for ONECUT1)

Maturity onset diabetes of the young

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

Drugs & Compounds
for ONECUT1 gene

Transcripts
for ONECUT1 gene

Expression
for ONECUT1 gene

ONECUT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAGAAC

10/25 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 25)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	PancreasDorsal Pancreatic BudPancreatic Progenitor Cells			Pancreas
	PancreasPancreatic AciniAcinar Cells			Pancreas
	PancreasPancreatic DuctsDuct Cells			Pancreas
	PancreasVentral Pancreatic BudPancreatic Progenitor Cells			Pancreas
	Gut TubeDorsal Foregut EndodermDorsal Foregut Endoderm Cells			Endoderm
	Gut TubeGut TubePrimitive Gut Endoderm Cells			Endoderm
	Gut TubeVentral Foregut EndodermHepatic Endoderm Cells			Liver
	Gut TubeVentral Foregut EndodermVentral Foregut Endoderm Cells			Endoderm
	LiverIntrahepatic Biliary TreeImmature Biliary Epithelial Cells			Liver
	LiverLiver BudHepatoblasts			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 9 LifeMap Cells
	Name			Category
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	Posterior foregut-like cells (A scalable, suspensi...)
	Pancreatic progenitor-like cells (A two-step protocol ...)
	Indolactam V-induced cells (Derivation of pancre...)
	Posterior foregut endoderm-like cells (Generation of beta c...)
	Hepatocyte-like cells (Functional hepatocyt...)
	Pancreatic progenitor-like cells (Derivation of beta c...)
	beta-like cells (Derivation of beta c...)
	Expanded pancreatic progenitor cells (Derivation of beta c...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ONECUT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ONECUT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ONECUT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ONECUT1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ONECUT1

Orthologs
for ONECUT1 gene

Paralogs
for ONECUT1 gene

Paralogs for ONECUT1 gene

CUX2²  ONECUT2²  ONECUT3²  CUX1²  

2 SIMAP similar genes for ONECUT1 using alignment to 3 protein entries:     HNF6_HUMAN (see all proteins):

ONECUT2    ONECUT3

ONECUT1 for paralogs           About GeneDecksing

Genomic Variants
for ONECUT1 gene

10/653 NCBI SNPs in ONECUT1 are shown (see all 653)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1916548001,2		--	53048884(+)	GAAAAC/GTCATA	1	--	ds5001		0	--	--	--	--
rs1150578151,2		--	53049001(+)	AATAGC/TTTTGG	1	--	ds5001		1		WA	118
rs24403331,2	C,F,A,H,	--	53049094(-)	AAACAA/TGAGTC	1	--	ds5001		30		NA NS EA WA CSA	2710
rs1852731121,2		--	53049195(+)	TCTGCA/CTTTAG	1	--	ds5001		0	--	--	--	--
rs1456054731,2		--	53049224(+)	TCAAAC/TGTTAG	1	--	ds5001		0	--	--	--	--
rs1489115831,2		--	53049225(+)	CAAACG/TTTAGG	1	--	ds5001		0	--	--	--	--
rs1426116851,2		--	53049372(+)	GACACA/CATACA	1	--	ut31		0	--	--	--	--
rs1509959101,2		--	53049374(+)	CACCAC/TACACC	1	--	ut31		0	--	--	--	--
rs1421720401,2		--	53049383(+)	CCTTCA/GTGGCA	1	--	ut31		0	--	--	--	--
rs1458282231,2		--	53049481(+)	CACAGC/TGAGGA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for ONECUT1 (53049186 - 53083273 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ONECUT1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ONECUT1

DNA2.0 Custom Variant and Variant Library Synthesis for ONECUT1

Disorders / Diseases
for ONECUT1 gene

17 diseases for ONECUT1

2 Novoseek disease relationships for ONECUT1 gene    About this table

Publications
for ONECUT1 gene

PubMed articles for ONECUT1 gene, integrated from 9 sources (see all 66): (articles sorted by number of sources associating them with ONECUT1)

Utopia: connect your pdf to the dynamic world of online information

1. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. (PubMed id 10491763)^{1, 2, 9} Moeller A.M.... Pedersen O. (1999)
2. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. (PubMed id 8887657)^{1, 3} Samadani U. and Costa R.H. (1996)
3. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. (PubMed id 8790352)^{1, 3} Lemaigre F.P....Rousseau G.G. (1996)
4. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. (PubMed id 12509444)^{1, 9} Rausa F.M....Costa R.H. (2003)
5. Loss of ONECUT1 expression in human pancreatic cancer cells. (PubMed id 18097590)^{1, 9} Jiang X....Kleeff J. (2008)
6. Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation. (PubMed id 18459945)^{1, 9} Lee Y.S....Choi H.S. (2008)
7. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. (PubMed id 17283222)^{1, 9} Lehner F....Borlak J. (2007)
8. Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. (PubMed id 15304484)^{1, 9} Rausa F.M....Costa R.H. (2004)
9. Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). (PubMed id 10811635)^{1, 9} Lannoy V.J....Lemaigre F.P. (2000)
10. Antiglucocorticoid activity of hepatocyte nuclear factor-6. (PubMed id 10430878)^{1, 9} Pierreux C.E....Lemaigre F.P. (1999)

External Searches for ONECUT1 gene

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Products
for ONECUT1 gene