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Aliases for OMP Gene

Aliases for OMP Gene

  • Olfactory Marker Protein 2 3
  • Olfactory Neuronal-Specific Protein 4

External Ids for OMP Gene

Previous GeneCards Identifiers for OMP Gene

  • GC11P079140
  • GC11P078352
  • GC11P077036
  • GC11P076540
  • GC11P076491
  • GC11P076813

Summaries for OMP Gene

Entrez Gene Summary for OMP Gene

  • Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for OMP Gene

OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include haemophilus influenzae and epiglottitis. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for OMP Gene

  • May act as a modulator of the olfactory signal-transduction cascade

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene

Genomics for OMP Gene

Regulatory Elements for OMP Gene

Genomic Location for OMP Gene

Chromosome:
11
Start:
77,102,840 bp from pter
End:
77,103,331 bp from pter
Size:
492 bases
Orientation:
Plus strand

Genomic View for OMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMP Gene

Proteins for OMP Gene

  • Protein details for OMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47874-OMP_HUMAN
    Recommended name:
    Olfactory marker protein
    Protein Accession:
    P47874
    Secondary Accessions:
    • Q562G2

    Protein attributes for OMP Gene

    Size:
    163 amino acids
    Molecular mass:
    18937 Da
    Quaternary structure:
    • Interacts with BEX1 and BEX2.

neXtProt entry for OMP Gene

Proteomics data for OMP Gene at MOPED

Post-translational modifications for OMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OMP Gene

Domains & Families for OMP Gene

Protein Domains for OMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47874

UniProtKB/Swiss-Prot:

OMP_HUMAN :
  • Belongs to the olfactory marker protein family.
Family:
  • Belongs to the olfactory marker protein family.
genes like me logo Genes that share domains with OMP: view

No data available for Gene Families for OMP Gene

Function for OMP Gene

Molecular function for OMP Gene

GENATLAS Biochemistry:
olfactory marker protein, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
May act as a modulator of the olfactory signal-transduction cascade

Gene Ontology (GO) - Molecular Function for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with OMP: view
genes like me logo Genes that share phenotypes with OMP: view

Animal Models for OMP Gene

MGI Knock Outs for OMP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OMP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for OMP Gene

Localization for OMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OMP Gene COMPARTMENTS Subcellular localization image for OMP gene
Compartment Confidence
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IBA --
GO:0030424 axon IBA --
GO:0043025 neuronal cell body IBA --
genes like me logo Genes that share ontologies with OMP: view

Pathways & Interactions for OMP Gene

SuperPathways for OMP Gene

No Data Available

Interacting Proteins for OMP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000436376%0d%0a9606.ENSP00000361813%0d%0a9606.ENSP00000442521%0d%0a
Selected Interacting proteins: P47874-OMP_HUMAN ENSP00000436376 for OMP Gene via I2D STRING

Gene Ontology (GO) - Biological Process for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS 8790421
GO:0007608 sensory perception of smell IEA --
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Pathways by source and SIGNOR curated interactions for OMP Gene

Drugs & Compounds for OMP Gene

(11) Drugs for OMP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ceftazidime Approved Pharma 55
Cefuroxime Approved Pharma 46
Ciprofloxacin Approved, Investigational Pharma 200
Imipenem Approved Pharma 43
Iron Approved Pharma 957

(3) Additional Compounds for OMP Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Agarose
Polyacrylamide
polysaccharide
genes like me logo Genes that share compounds with OMP: view

Transcripts for OMP Gene

mRNA/cDNA for OMP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OMP Gene

Olfactory marker protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OMP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMP Gene

No ASD Table

Relevant External Links for OMP Gene

GeneLoc Exon Structure for
OMP
ECgene alternative splicing isoforms for
OMP

Expression for OMP Gene

mRNA expression in normal human tissues for OMP Gene

mRNA differential expression in normal tissues according to GTEx for OMP Gene

This gene is overexpressed in Colon - Transverse (x10.1), Liver (x5.9), and Small Intestine - Terminal Ileum (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMP Gene



SOURCE GeneReport for Unigene cluster for OMP Gene Hs.673853

mRNA Expression by UniProt/SwissProt for OMP Gene

P47874-OMP_HUMAN
Tissue specificity: Uniquely associated with mature olfactory receptor neurons
genes like me logo Genes that share expression patterns with OMP: view

Protein tissue co-expression partners for OMP Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for OMP Gene

Orthologs for OMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OMP 35
  • 87.12 (n)
  • 84.66 (a)
dog
(Canis familiaris)
Mammalia OMP 35
  • 90.18 (n)
  • 88.34 (a)
mouse
(Mus musculus)
Mammalia Omp 35
  • 88.55 (n)
  • 89.57 (a)
Omp 16
Omp 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OMP 35
  • 98.57 (n)
  • 97.55 (a)
OMP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Omp 35
  • 89.98 (n)
  • 90.8 (a)
chicken
(Gallus gallus)
Aves OMP 35
  • 65.56 (n)
  • 58.28 (a)
lizard
(Anolis carolinensis)
Reptilia OMP 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia omp 35
  • 64.41 (n)
  • 56.76 (a)
zebrafish
(Danio rerio)
Actinopterygii ompb 35
  • 61.97 (n)
  • 55.7 (a)
ompa 36
  • 51 (a)
OneToMany
ompb 36
  • 49 (a)
OneToMany
Species with no ortholog for OMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMP Gene

ENSEMBL:
Gene Tree for OMP (if available)
TreeFam:
Gene Tree for OMP (if available)

Paralogs for OMP Gene

No data available for Paralogs for OMP Gene

Variants for OMP Gene

Sequence variations from dbSNP and Humsavar for OMP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_051254 -
VAR_051255 -

Structural Variations from Database of Genomic Variants (DGV) for OMP Gene

Variant ID Type Subtype PubMed ID
dgv1225n71 CNV Loss 21882294
nsv825998 CNV Gain 20364138

Variation tolerance for OMP Gene

Residual Variation Intolerance Score: 85.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OMP Gene

HapMap Linkage Disequilibrium report
OMP
Human Gene Mutation Database (HGMD)
OMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene

Disorders for OMP Gene

MalaCards: The human disease database

(9) MalaCards diseases for OMP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
haemophilus influenzae
  • h. influenzae
epiglottitis
  • acute epiglottitis and supraglottitis
typhoid fever
  • paratyphoid fever
neisseria meningitidis infection
  • meningococcal disease
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerves nos
- elite association
Search OMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for OMP

Genetic Association Database (GAD)
OMP
Human Genome Epidemiology (HuGE) Navigator
OMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OMP
genes like me logo Genes that share disorders with OMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMP Gene

Publications for OMP Gene

  1. Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans K.L. … Brown S.D. (Hum. Mol. Genet. 1993) 2 23 67
  2. Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia. (PMID: 20424311) Hwa W.E. … Devi S.S. (Indian J. Med. Res. 2010) 23 67
  3. Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody. (PMID: 19915959) Bagchi A.K. … Mukherjee J. (Mol. Cell. Biochem. 2010) 23 67
  4. Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia. (PMID: 20163713) Baldo L. … Werren J.H. (BMC Evol. Biol. 2010) 23 67
  5. [Evaluation of Western Blot method for the detection of antibodies to Helicobacter pylori antigens in patients with gastric carcinoma and cases with epigastric complaints]. (PMID: 20455395) GA1dA1cA1oA9lu H. … Ilhan M. (Mikrobiyol Bul 2010) 23 67

Products for OMP Gene

Sources for OMP Gene

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