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Aliases for OMP Gene

Aliases for OMP Gene

  • Olfactory Marker Protein 2 3
  • Olfactory Neuronal-Specific Protein 4

External Ids for OMP Gene

Previous GeneCards Identifiers for OMP Gene

  • GC11P079140
  • GC11P078352
  • GC11P077036
  • GC11P076540
  • GC11P076491
  • GC11P076813

Summaries for OMP Gene

Entrez Gene Summary for OMP Gene

  • Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for OMP Gene

OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include leptospirosis and epiglottitis. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for OMP Gene

  • May act as a modulator of the olfactory signal-transduction cascade

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene

Genomics for OMP Gene

Regulatory Elements for OMP Gene

Genomic Location for OMP Gene

Start:
77,102,840 bp from pter
End:
77,103,331 bp from pter
Size:
492 bases
Orientation:
Plus strand

Genomic View for OMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMP Gene

Proteins for OMP Gene

  • Protein details for OMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47874-OMP_HUMAN
    Recommended name:
    Olfactory marker protein
    Protein Accession:
    P47874
    Secondary Accessions:
    • Q562G2

    Protein attributes for OMP Gene

    Size:
    163 amino acids
    Molecular mass:
    18937 Da
    Quaternary structure:
    • Interacts with BEX1 and BEX2.

neXtProt entry for OMP Gene

Proteomics data for OMP Gene at MOPED

Post-translational modifications for OMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OMP Gene

Domains for OMP Gene

Protein Domains for OMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47874

UniProtKB/Swiss-Prot:

OMP_HUMAN :
  • P47874
Family:
  • Belongs to the olfactory marker protein family.
genes like me logo Genes that share domains with OMP: view

No data available for Gene Families for OMP Gene

Function for OMP Gene

Molecular function for OMP Gene

GENATLAS Biochemistry:
olfactory marker protein, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
May act as a modulator of the olfactory signal-transduction cascade

Gene Ontology (GO) - Molecular Function for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with OMP: view
genes like me logo Genes that share phenotypes with OMP: view

Animal Models for OMP Gene

MGI Knock Outs for OMP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OMP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OMP Gene

Localization for OMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0030424 axon IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Subcellular locations from COMPARTMENTS for OMP Gene

Pathways for OMP Gene

SuperPathways for OMP Gene

No Data Available

Interacting Proteins for OMP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000436376%0d%0a9606.ENSP00000442521%0d%0a9606.ENSP00000361813%0d%0a
Selected Interacting proteins: ENSP00000436376 P47874-OMP_HUMAN for OMP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS 8790421
GO:0007608 sensory perception of smell IEA --
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Pathways by source for OMP Gene

Compounds for OMP Gene

(14) Novoseek inferred chemical compound relationships for OMP Gene

Compound -log(P) Hits PubMed IDs
flagellin 46.3 4
imipenem 45.6 8
polysaccharide 34.2 2
ceftazidime 28.7 2
cefuroxime 19.9 2
genes like me logo Genes that share compounds with OMP: view

Transcripts for OMP Gene

mRNA/cDNA for OMP Gene

(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OMP Gene

Olfactory marker protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OMP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMP Gene

No ASD Table

Relevant External Links for OMP Gene

GeneLoc Exon Structure for
OMP
ECgene alternative splicing isoforms for
OMP

Expression for OMP Gene

mRNA expression in normal human tissues for OMP Gene

mRNA differential expression in normal tissues according to GTEx for OMP Gene

This gene is overexpressed in Colon - Transverse (10.1), Liver (5.9), and Small Intestine - Terminal Ileum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OMP Gene

SOURCE GeneReport for Unigene cluster for OMP Gene Hs.673853

mRNA Expression by UniProt/SwissProt for OMP Gene

P47874-OMP_HUMAN
Tissue specificity: Uniquely associated with mature olfactory receptor neurons
genes like me logo Genes that share expressions with OMP: view

Expression partners for OMP Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for OMP Gene

Orthologs for OMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OMP 35
  • 87.12 (n)
  • 84.66 (a)
dog
(Canis familiaris)
Mammalia OMP 35
  • 90.18 (n)
  • 88.34 (a)
mouse
(Mus musculus)
Mammalia Omp 35
  • 88.55 (n)
  • 89.57 (a)
Omp 16
Omp 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OMP 35
  • 98.57 (n)
  • 97.55 (a)
OMP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Omp 35
  • 89.98 (n)
  • 90.8 (a)
chicken
(Gallus gallus)
Aves OMP 35
  • 65.56 (n)
  • 58.28 (a)
lizard
(Anolis carolinensis)
Reptilia OMP 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia omp 35
  • 64.41 (n)
  • 56.76 (a)
zebrafish
(Danio rerio)
Actinopterygii ompb 35
  • 61.97 (n)
  • 55.7 (a)
ompa 36
  • 51 (a)
OneToMany
ompb 36
  • 49 (a)
OneToMany
Species with no ortholog for OMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMP Gene

ENSEMBL:
Gene Tree for OMP (if available)
TreeFam:
Gene Tree for OMP (if available)

Paralogs for OMP Gene

No data available for Paralogs for OMP Gene

Variants for OMP Gene

Sequence variations from dbSNP and Humsavar for OMP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_051254 -
VAR_051255 -

Structural Variations from Database of Genomic Variants (DGV) for OMP Gene

Variant ID Type Subtype PubMed ID
dgv1225n71 CNV Loss 21882294
nsv825998 CNV Gain 20364138

Relevant External Links for OMP Gene

HapMap Linkage Disequilibrium report
OMP
Human Gene Mutation Database (HGMD)
OMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene

Disorders for OMP Gene

(18) Novoseek inferred disease relationships for OMP Gene

Disease -log(P) Hits PubMed IDs
meningococcal diseases 42.3 2
epiglottitis 42 1
typhoid fever 39.5 5
usher syndrome 38.6 1
arthritis reactive 34.7 1

Relevant External Links for OMP

Genetic Association Database (GAD)
OMP
Human Genome Epidemiology (HuGE) Navigator
OMP
genes like me logo Genes that share disorders with OMP: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for OMP Gene

Publications for OMP Gene

  1. Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans K.L. … Brown S.D. (Hum. Mol. Genet. 1993) 2 3 23
  2. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PMID: 8034318) Buiakova O.I. … Margolis F.L. (Genomics 1994) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for OMP Gene

Sources for OMP Gene

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