Aliases for OMP Gene
External Ids for OMP Gene
- HGNC: 8136
- Entrez Gene: 4975
- Ensembl: ENSG00000254550
- OMIM: 164340
- UniProtKB: P47874
Previous GeneCards Identifiers for OMP Gene
- GC11P079140
- GC11P078352
- GC11P077036
- GC11P076540
- GC11P076491
- GC11P076813
Summaries for OMP Gene
-
Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]
GeneCards Summary for OMP Gene
OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include Epiglottitis and Haemophilus Influenzae. Gene Ontology (GO) annotations related to this gene include signal transducer activity.
UniProtKB/Swiss-Prot for OMP Gene
-
May act as a modulator of the olfactory signal-transduction cascade.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene
Genomics for OMP Gene
GeneHancer (GH) Regulatory Elements for OMP Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11I077102 | Promoter | 0.5 | EPDnew | 550.8 | +0.1 | 71 | 0.1 | OMP MYO7A CAPN5 | ||
GH11I077034 | Promoter/Enhancer | 1.6 | EPDnew ENCODE dbSUPER | 12 | -67.1 | -67072 | 3.2 | PKNOX1 FOXA2 MLX NFIB ZFP64 NEUROD1 RARA SCRT2 FOS RCOR1 | B3GNT6 OMP MYO7A ACER3 CAPN5 LOC105369399 | |
GH11I077045 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 12.6 | -55.8 | -55751 | 2.6 | PKNOX1 ARID4B SIN3A YY1 ELK1 ARID2 ZNF143 ATF7 RUNX3 RXRA | LOC105369399 OMP CAPN5 B3GNT6 | |
GH11I077139 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 11.7 | +38.1 | 38060 | 2.4 | MAX SIN3A ZMYM3 ZIC2 GATA3 ZBTB48 POLR2A PRDM10 ATF7 FOS | OMP GDPD4 ENSG00000254632 MYO7A PIR53181 | |
GH11I077039 | Enhancer | 0.7 | Ensembl ENCODE | 11.8 | -62.8 | -62809 | 1.4 | CTCF USF1 MAX ZNF143 ZBTB33 RAD21 EZH2 | OMP MYO7A ACER3 LOC105369399 B3GNT6 |
- Top Transcription factor binding sites by QIAGEN in the OMP gene promoter:
Regulatory Element Products
Genomic Locations for OMP Gene
- chr11:77,102,840-77,103,331
- (GRCh38/hg38)
- Size:
- 492 bases
- Orientation:
- Plus strand
- chr11:76,813,886-76,814,377
- (GRCh37/hg19)
Genomic View for OMP Gene
- Cytogenetic band:
-
- 11q13.5 by Ensembl
- 11q13.5 by Entrez Gene
- 11q13.5 by HGNC


RefSeq DNA sequence for OMP Gene
Proteins for OMP Gene
-
Protein details for OMP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P47874-OMP_HUMAN
- Recommended name:
- Olfactory marker protein
- Protein Accession:
- P47874
- Q562G2
Protein attributes for OMP Gene
- Size:
- 163 amino acids
- Molecular mass:
- 18937 Da
- Quaternary structure:
-
- Interacts with BEX1 and BEX2.
Protein Expression for OMP Gene
Post-translational modifications for OMP Gene
Other Protein References for OMP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for OMP
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-
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-
ProSci Proteins for OMP
-
Abcam proteins for OMP
Assay Products
- antibodies-online: Search results for available OMP related products ranked by validation data
No data available for DME Specific Peptides for OMP Gene
Domains & Families for OMP Gene
Gene Families for OMP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for OMP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OMP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P47874- Family:
-
- Belongs to the olfactory marker protein family.
Function for OMP Gene
Molecular function for OMP Gene
- GENATLAS Biochemistry:
- olfactory marker protein, G protein coupled receptor superfamily
- UniProtKB/Swiss-Prot Function:
- May act as a modulator of the olfactory signal-transduction cascade.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004871 | signal transducer activity | IBA | -- |
Phenotypes for OMP Gene
- MGI mutant phenotypes for OMP:
- inferred from 9 alleles
- GenomeRNAi human phenotypes for OMP:
Animal Models for OMP Gene
Animal Model Products
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-
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-
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-
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-
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-
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Clone Products
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-
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Cell Line Products
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OMP Gene
Localization for OMP Gene
Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene
- Cytoplasm.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IEA,IBA | -- |
GO:0030424 | axon | IEA,IBA | -- |
GO:0043025 | neuronal cell body | IEA,IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OMP Gene
Pathways & Interactions for OMP Gene
Interacting Proteins for OMP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IBA,TAS | -- |
GO:0007268 | chemical synaptic transmission | TAS | 8790421 |
GO:0007608 | sensory perception of smell | IBA,TAS | -- |
GO:0022008 | neurogenesis | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for OMP Gene
Transcripts for OMP Gene
mRNA/cDNA for OMP Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for OMP Gene
CRISPR Products
-
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-
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-
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-
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Clone Products
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-
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Expression for OMP Gene
mRNA differential expression in normal tissues according to GTEx for OMP Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMP Gene
NURSA nuclear receptor signaling pathways regulating expression of OMP Gene:
OMPSOURCE GeneReport for Unigene cluster for OMP Gene:
Hs.673853mRNA Expression by UniProt/SwissProt for OMP Gene:
P47874-OMP_HUMANEvidence on tissue expression from TISSUES for OMP Gene
- Lung(2.6)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for OMP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OMP Gene
Orthologs for OMP Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | OMP 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | OMP 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Omp 33 |
|
||
mouse (Mus musculus) |
Mammalia | Omp 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | OMP 33 |
|
||
chicken (Gallus gallus) |
Aves | OMP 33 |
|
||
lizard (Anolis carolinensis) |
Reptilia | OMP 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | omp 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ompb 33 34 |
|
||
ompa 34 |
|
OneToMany |
- Species where no ortholog for OMP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for OMP Gene
No data available for Paralogs for OMP Gene
Variants for OMP Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000267923 | -- | 77,101,079(+) | C/T | upstream_transcript_variant | |
rs1002279500 | -- | 77,103,467(+) | C/T | downstream_transcript_variant | |
rs1006840813 | -- | 77,101,159(+) | G/A | upstream_transcript_variant | |
rs1007136996 | -- | 77,101,579(+) | T/G | upstream_transcript_variant | |
rs1008852038 | -- | 77,103,501(+) | C/T | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1230n100 | CNV | gain | 25217958 |
dgv1231n100 | CNV | gain | 25217958 |
dgv1232n100 | CNV | gain | 25217958 |
dgv1233n100 | CNV | gain | 25217958 |
nsv1040996 | CNV | gain | 25217958 |
nsv1044491 | CNV | gain | 25217958 |
nsv1047361 | CNV | gain | 25217958 |
nsv825998 | CNV | gain | 20364138 |
Additional Variant Information for OMP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene
Disorders for OMP Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
epiglottitis |
|
|
haemophilus influenzae |
|
|
typhoid fever |
|
|
neisseria meningitidis infection |
|
|
cranial nerve malignant neoplasm |
|
|
Additional Disease Information for OMP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for OMP Gene
Publications for OMP Gene
- Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PMID: 8034318) Buiakova OI … Margolis FL (Genomics 1994) 3 4 22 58
- Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans KL … Brown SD (Human molecular genetics 1993) 2 3 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody. (PMID: 19915959) Bagchi AK … Mukherjee J (Molecular and cellular biochemistry 2010) 22 58
Products for OMP Gene
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Sources for OMP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (8) Gene Wiki
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- (25) HMDB
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (44) GAD
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- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
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- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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