OMP Gene(Protein Coding)

Olfactory Marker Protein

GCID:: GC11P077102

GIFtS:: 54

Genes Participants

Aliases for OMP Gene

Olfactory Marker Protein ² ³ ⁵
Olfactory Neuronal-Specific Protein ⁴

External Ids for OMP Gene

HGNC: 8136
Entrez Gene: 4975
Ensembl: ENSG00000254550
OMIM: 164340
UniProtKB: P47874

Previous GeneCards Identifiers for OMP Gene

GC11P079140
GC11P078352
GC11P077036
GC11P076540
GC11P076491
GC11P076813

Export aliases for OMP gene to outside databases

Summaries for OMP Gene

Entrez Gene Summary for OMP Gene

Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for OMP Gene

OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include Epiglottitis and Haemophilus Influenzae. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for OMP Gene

OMP_HUMAN,P47874

May act as a modulator of the olfactory signal-transduction cascade.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene

Genomics for OMP Gene

Regulatory Elements for OMP Gene

Enhancers for OMP Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around OMP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OMP gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for OMP Gene

Chromosome:: 11

Start:: 77,102,840 bp from pter
End:: 77,103,331 bp from pter

Size:: 492 bases
Orientation:: Plus strand

Genomic View for OMP Gene

Genes around OMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

11q13.5 by Ensembl
11q13.5 by Entrez Gene
11q13.5 by HGNC

OMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for OMP Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OMP Gene

Proteins for OMP Gene

Protein details for OMP Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P47874-OMP_HUMAN

Recommended name:

Olfactory marker protein

Protein Accession:

P47874

Secondary Accessions:
- Q562G2
Protein attributes for OMP Gene
Size:

163 amino acids

Molecular mass:

18937 Da
Quaternary structure:
Interacts with BEX1 and BEX2.

neXtProt entry for OMP Gene

Proteomics data for OMP Gene at MOPED

Protein Expression for OMP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OMP Gene

Modification sites at PhosphoSitePlus
- P47874
Modification sites at neXtProt
- NX_P47874

Other Protein References for OMP Gene

ENSEMBL proteins:

ENSP00000436376

REFSEQ proteins:

NP_006180.1

Antibody Products

EMD Millipore Complete listing of Mono and Polychlonal Antibodies for OMP

Browse R&D Systems for Antibodies

OriGene Antibodies for OMP
- TA345161
Custom Antibody Services

Novus Biologicals Antibodies for OMP

Abcam antibodies for Olfactory Marker Protein

Browse Antibodies at Cloud-Clone Corp.

Invitrogen Antibodies for OMP

antibodies-online Antibodies for OMP: See all 55

GeneTex OMP antibody for OMP

Santa Cruz Biotechnology (SCBT) Antibodies for OMP

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

Browse R&D Systems for Human Recombinant Proteins

Browse Enzo Life Sciences for proteins

OriGene Purified Proteins for OMP
Search Origene for MassSpec and Protein Over-expression Lysates for OMP
Origene Custom Protein Services for OMP

GenScript Custom Purified and Recombinant Proteins Services for OMP

Novus Biologicals proteins and lysates for OMP

Sino Biological Recombinant Proteins for OMP
Browse Sino Biological Cell Lysates

ProSpec Recombinant Proteins for OMP

Browse Proteins at Cloud-Clone Corp.

Search eBioscience for OMP related proteins

antibodies-online Proteins for OMP: See all 12
Search antibodies-online for peptides

Search GeneTex for Proteins for OMP

Abcam proteins for Olfactory Marker Protein

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for OMP

Browse Enzo Life Sciences for kits & assays

Browse Assay Kits at Cloud-Clone Corp.

Search eBioscience for OMP related elisas

Search antibodies-online for kits

Search for Assays for OMP at Abcam

No data available for DME Specific Peptides for OMP Gene

Domains & Families for OMP Gene

Protein Domains for OMP Gene

InterPro:

Olfactory_marker

Blocks:

Olfactory marker protein

ProtoNet:

P47874

Suggested Antigen Peptide Sequences for OMP Gene

GenScript: Design optimal peptide antigens:

Olfactory neuronal-specific protein (OMP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47874

UniProtKB/Swiss-Prot:

OMP_HUMAN :

Belongs to the olfactory marker protein family.

Family:

Belongs to the olfactory marker protein family.

No data available for Gene Families for OMP Gene

Function for OMP Gene

Molecular function for OMP Gene

GENATLAS Biochemistry:

olfactory marker protein, G protein coupled receptor superfamily

UniProtKB/Swiss-Prot Function:

May act as a modulator of the olfactory signal-transduction cascade.

OMP_HUMAN,P47874

Phenotypes for OMP Gene

MGI mutant phenotypes for OMP:

inferred from 9 alleles

GenomeRNAi human phenotypes for OMP:

Animal Models for OMP Gene

MGI Knock Outs for OMP:

Omp ^{tm1.1(COP4*/EYFP)Tboz}
Omp ^tm1Mom
Omp ^tm1Flm
Omp ^tm2(spH)Mom
Omp ^tm3Mom

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OMP Gene

Localization for OMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene

Cytoplasm.

P47874-OMP_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	4
cytosol	3
cytoskeleton	2
extracellular	1

Gene Ontology (GO) - Cellular Components for OMP Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

Pathways & Interactions for OMP Gene

SuperPathways for OMP Gene

More details on SuperPathways for OMP

No Data Available

Interacting Proteins for OMP Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000436376%0d%0a9606.ENSP00000442521%0d%0a9606.ENSP00000361813%0d%0a — STRING Interaction Network Preview (showing 2 interactants - click image to see details)

Selected Interacting proteins: ENSP00000436376 P47874-OMP_HUMAN for OMP Gene via STRING I2D

Symbol	External ID(s)	Details
BEX1	ENSP00000361813 ²⁰ Q9HBH7 ²¹	STRING: ENSP00000361813 I2D: score=3
BEX2	ENSP00000442521 ²⁰ Q9BXY8 ²¹	STRING: ENSP00000442521 I2D: score=1

Gene Ontology (GO) - Biological Process for OMP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OMP Gene

Drugs & Compounds for OMP Gene

(11) Drugs for OMP Gene - From: Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials

(3) Additional Compounds for OMP Gene - From: Novoseek

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OMP

Browse compounds at ApexBio

Transcripts for OMP Gene

mRNA/cDNA for OMP Gene

(1) REFSEQ mRNAs :

NM_006189.1

(2) Additional mRNA sequences :

(3) Selected AceView cDNA sequences:

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

ENST00000529803 (uc010rsk.2)

Unigene Clusters for OMP Gene

Olfactory marker protein:

Hs.673853

Representative Sequences:

EL736194

CRISPR Products

OriGene CRISPR knockouts for OMP
- KN221572
- KN312589

Santa Cruz Biotechnology (SCBT) CRISPR for OMP

GenScript: Design CRISPR guide RNA sequences for OMP

miRNA Products

Search ViGene Biosciences for OMP

Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhibitory RNA Products

Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for OMP
Browse OriGene Inhibitory RNA Products For OMP

ViGene Biosciences ready-to-package AAV shRNAs for OMP gene
- SH869015

Search Santa Cruz Biotechnology (SCBT) for OMP siRNA/shRNA

Clone Products

OriGene clones in human for OMP
OriGene ORF clones in human,mouse,rat for OMP
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector
- NM_006189

Sino Biological Human cDNA Clone for OMP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for OMP

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for OMP Gene

No ASD Table

Relevant External Links for OMP Gene

GeneLoc Exon Structure for: OMP
ECgene alternative splicing isoforms for: OMP

Expression for OMP Gene

mRNA expression in normal human tissues for OMP Gene

mRNA differential expression in normal tissues according to GTEx for OMP Gene

This gene is overexpressed in Colon - Transverse (x10.1), Liver (x5.9), and Small Intestine - Terminal Ileum (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OMP Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for OMP Gene

SOURCE GeneReport for Unigene cluster for OMP Gene Hs.673853

mRNA Expression by UniProt/SwissProt for OMP Gene

P47874-OMP_HUMAN

Tissue specificity: Uniquely associated with mature olfactory receptor neurons.

Protein tissue co-expression partners for OMP Gene

Primer Products

OriGene qPCR primer pairs for OMP
- HP209174

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for OMP Gene

Orthologs for OMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMP Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	OMP ³⁵	87.12 (n) 84.66 (a)		613648 XM_005216338.1 XP_005216395.1
dog (Canis familiaris)	Mammalia	OMP ³⁵	90.18 (n) 88.34 (a)		607920 XM_005633460.1 XP_005633517.1
mouse (Mus musculus)	Mammalia	Omp ³⁵	88.55 (n) 89.57 (a)		18378 NM_011010.2 NP_035140.1
		Omp ¹⁶			98143359
		Omp ³⁶	90 (a)	OneToOne	7:98143360-98145502
chimpanzee (Pan troglodytes)	Mammalia	OMP ³⁵	98.57 (n) 97.55 (a)		748851 XM_001175038.3 XP_001175038.1
chimpanzee (Pan troglodytes)	Mammalia	OMP ³⁶	98 (a)	OneToOne	11:74884502-74884993
rat (Rattus norvegicus)	Mammalia	Omp ³⁵	89.98 (n) 90.8 (a)		24612 NM_012616.1 NP_036748.1
chicken (Gallus gallus)	Aves	OMP ³⁵	65.56 (n) 58.28 (a)		101749160 XM_004938942.1 XP_004938999.1
lizard (Anolis carolinensis)	Reptilia	OMP ³⁶	62 (a)	OneToOne	GL343493.1:38729-39217
tropical clawed frog (Silurana tropicalis)	Amphibia	omp ³⁵	64.41 (n) 56.76 (a)		394662 NM_203734.1 NP_989065.2
zebrafish (Danio rerio)	Actinopterygii	ompb ³⁵	61.97 (n) 55.7 (a)		317636 NM_173281.2 NP_775388.2
		ompa ³⁶	51 (a)	OneToMany	18:2523296-2526398
		ompb ³⁶	49 (a)	OneToMany	21:21139881-21141846

Species with no ortholog for OMP:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
oppossum (Monodelphis domestica)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
platypus (Ornithorhynchus anatinus)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea squirt (Ciona intestinalis)
sea squirt (Ciona savignyi)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for OMP Gene

ENSEMBL:: Gene Tree for OMP (if available)
TreeFam:: Gene Tree for OMP (if available)

Paralogs for OMP Gene

No data available for Paralogs for OMP Gene

Variants for OMP Gene

Sequence variations from dbSNP and Humsavar for OMP Gene

SNP ID	Clin	Chr 11 pos	Sequence Context	AA Info	Type
VAR_051254	-
VAR_051255	-

Structural Variations from Database of Genomic Variants (DGV) for OMP Gene

Variant ID	Type	Subtype	PubMed ID
dgv1225n71	CNV	Loss	21882294
nsv825998	CNV	Gain	20364138

Variation tolerance for OMP Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OMP Gene

Human Gene Mutation Database (HGMD): OMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene

Disorders for OMP Gene

(8) MalaCards diseases for OMP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
epiglottitis	acute epiglottitis	8487295
haemophilus influenzae	h. influenzae
cranial nerve malignant neoplasm	malignant neoplasm of cranial nerve
neisseria meningitidis infection	meningococcal disease	1377227
typhoid fever	diverticulosis of colon with hemorrhage	8513812

- elite association - COSMIC cancer census association via MalaCards

Search OMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for OMP

Genetic Association Database (GAD): OMP
Human Genome Epidemiology (HuGE) Navigator: OMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: OMP

Export disorders for OMP gene to outside databases

No data available for UniProtKB/Swiss-Prot and Genatlas for OMP Gene

Publications for OMP Gene

Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PMID: 8034318) Buiakova O.I. … Margolis F.L. (Genomics 1994) ³ ⁴ ²³ ⁶⁷
Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans K.L. … Brown S.D. (Hum. Mol. Genet. 1993) ² ³ ²³
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) ³
Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody. (PMID: 19915959) Bagchi A.K. … Mukherjee J. (Mol. Cell. Biochem. 2010) ²³
Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia. (PMID: 20163713) Baldo L. … Werren J.H. (BMC Evol. Biol. 2010) ²³