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OMP Gene(Protein Coding)

Olfactory Marker Protein

GCID:
GC11P077102
GIFtS:
53
Genes Participants
UDN Logo

Aliases for OMP Gene

Aliases for OMP Gene

  • Olfactory Marker Protein 2 3 5
  • Olfactory Neuronal-Specific Protein 4

External Ids for OMP Gene

Previous GeneCards Identifiers for OMP Gene

  • GC11P079140
  • GC11P078352
  • GC11P077036
  • GC11P076540
  • GC11P076491
  • GC11P076813

Summaries for OMP Gene

Entrez Gene Summary for OMP Gene

  • Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for OMP Gene

OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include Epiglottitis and Haemophilus Influenzae. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for OMP Gene

  • May act as a modulator of the olfactory signal-transduction cascade.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene

Genomics for OMP Gene

Products:

  1. Regulatory Element

Regulatory Elements for OMP Gene

Enhancers for OMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G077045 1.5 Ensembl ENCODE dbSUPER 12.6 -55.8 -55752 2.6 PKNOX1 ARID4B SIN3A YY1 ELK1 ZNF143 ZNF263 REST SMARCA4 RFX3 OMP CAPN5 LOC105369399 B3GNT6
GH11G077034 1.3 ENCODE dbSUPER 12 -67.1 -67073 3.2 HDGF PKNOX1 FOXA2 ARNT MLX ZFP64 ZNF766 FOS SP5 TBX21 OMP MYO7A ACER3 CAPN5 B3GNT6 LOC105369399
GH11G077139 1.3 Ensembl ENCODE dbSUPER 11.7 +38.1 38060 2.4 JUN ZMYM3 MAX RBBP5 ZIC2 YY1 GATA3 POLR2A ZBTB48 FOS OMP GDPD4 ENSG00000254632 MYO7A PIR53181
GH11G077039 0.9 Ensembl ENCODE 11.8 -62.8 -62810 1.4 CTCF RNF2 NR2F1 MAX RBBP5 RAD21 HDAC2 SMC3 KDM1A ZBTB33 OMP MYO7A ACER3 B3GNT6 LOC105369399
GH11G077048 0.8 ENCODE dbSUPER 12.9 -53.6 -53606 1.0 BCOR NFIC POLR2A ZMYM3 KDM1A OMP LOC105369399 LOC105369400
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OMP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OMP gene promoter:

Genomic Location for OMP Gene

Chromosome:
11
Start:
77,102,840 bp from pter
End:
77,103,331 bp from pter
Size:
492 bases
Orientation:
Plus strand

Genomic View for OMP Gene

Genes around OMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OMP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OMP Gene

Proteins for OMP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47874-OMP_HUMAN
    Recommended name:
    Olfactory marker protein
    Protein Accession:
    P47874
    Secondary Accessions:
    • Q562G2

    Protein attributes for OMP Gene

    Size:
    163 amino acids
    Molecular mass:
    18937 Da
    Quaternary structure:
    • Interacts with BEX1 and BEX2.

neXtProt entry for OMP Gene

Protein Expression for OMP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OMP

No data available for DME Specific Peptides for OMP Gene

Domains & Families for OMP Gene

Protein Domains for OMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47874

UniProtKB/Swiss-Prot:

OMP_HUMAN :
  • Belongs to the olfactory marker protein family.
Family:
  • Belongs to the olfactory marker protein family.
genes like me logo Genes that share domains with OMP: view

No data available for Gene Families for OMP Gene

Function for OMP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OMP Gene

GENATLAS Biochemistry:
olfactory marker protein, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
May act as a modulator of the olfactory signal-transduction cascade.

Gene Ontology (GO) - Molecular Function for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with OMP: view
genes like me logo Genes that share phenotypes with OMP: view

Animal Models for OMP Gene

MGI Knock Outs for OMP:
  • Omp tm1.1(COP4*/EYFP)Tboz
  • Omp tm1Mom
  • Omp tm1Flm
  • Omp tm2(spH)Mom
  • Omp tm3Mom

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OMP Gene

Localization for OMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OMP gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IBA --
GO:0030424 axon IEA,IBA --
GO:0043025 neuronal cell body IEA,IBA --
genes like me logo Genes that share ontologies with OMP: view

Pathways & Interactions for OMP Gene

SuperPathways for OMP Gene

PathCards logo More details on SuperPathways for OMP
No Data Available

Interacting Proteins for OMP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000436376%0d%0a9606.ENSP00000442521%0d%0a9606.ENSP00000361813%0d%0a9606.ENSP00000308928%0d%0a
Selected Interacting proteins: P47874-OMP_HUMAN ENSP00000436376 for OMP Gene via IID STRING

Gene Ontology (GO) - Biological Process for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS,IBA --
GO:0007268 chemical synaptic transmission TAS 8790421
GO:0007608 sensory perception of smell TAS,IBA --
GO:0022008 neurogenesis IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Pathways by source and SIGNOR curated interactions for OMP Gene

Drugs & Compounds for OMP Gene

Products:

  1. Drug

(11) Drugs for OMP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for OMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OMP: view

Transcripts for OMP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OMP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OMP Gene

Olfactory marker protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMP Gene

No ASD Table

Relevant External Links for OMP Gene

GeneLoc Exon Structure for
OMP
ECgene alternative splicing isoforms for
OMP

Expression for OMP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OMP Gene

mRNA expression in normal human tissues for OMP Gene
mRNA expression by BioGPS for OMP GenemRNA expression by GTEx for OMP Gene

mRNA differential expression in normal tissues according to GTEx for OMP Gene

This gene is overexpressed in Colon - Transverse (x10.1), Liver (x5.9), and Small Intestine - Terminal Ileum (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMP Gene



Protein tissue co-expression partners for OMP Gene

NURSA nuclear receptor signaling pathways regulating expression of OMP Gene:

OMP

SOURCE GeneReport for Unigene cluster for OMP Gene:

Hs.673853

mRNA Expression by UniProt/SwissProt for OMP Gene:

P47874-OMP_HUMAN
Tissue specificity: Uniquely associated with mature olfactory receptor neurons.

Evidence on tissue expression from TISSUES for OMP Gene

  • Lung(2.6)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with OMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OMP Gene

Orthologs for OMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OMP 34 35
  • 98.57 (n)
dog
(Canis familiaris)
 Mammalia OMP 34
  • 90.18 (n)
rat
(Rattus norvegicus)
 Mammalia Omp 34
  • 89.98 (n)
mouse
(Mus musculus)
 Mammalia Omp 34 16 35
  • 88.55 (n)
cow
(Bos Taurus)
 Mammalia OMP 34
  • 87.12 (n)
chicken
(Gallus gallus)
 Aves OMP 34
  • 65.56 (n)
lizard
(Anolis carolinensis)
 Reptilia OMP 35
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia omp 34
  • 64.41 (n)
zebrafish
(Danio rerio)
 Actinopterygii ompb 34 35
  • 61.97 (n)
ompa 35
  • 51 (a)
 OneToMany
Species where no ortholog for OMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMP Gene

ENSEMBL:
Gene Tree for OMP (if available)
TreeFam:
Gene Tree for OMP (if available)

Paralogs for OMP Gene

No data available for Paralogs for OMP Gene

Variants for OMP Gene

Sequence variations from dbSNP and Humsavar for OMP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000267923 -- 77,101,079(+) TGTCC(C/T)GTGGT intron-variant, upstream-variant-2KB
rs1002279500 -- 77,103,467(+) TGAGT(C/T)CCACA intron-variant, downstream-variant-500B
rs1006840813 -- 77,101,159(+) CATTC(A/G)TTCAT intron-variant, upstream-variant-2KB
rs1007136996 -- 77,101,579(+) CCCTC(G/T)GCTGT intron-variant, upstream-variant-2KB
rs1008852038 -- 77,103,501(+) GGGGC(C/T)AGCAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OMP Gene

Variant ID Type Subtype PubMed ID
dgv1230n100 CNV gain 25217958
dgv1231n100 CNV gain 25217958
dgv1232n100 CNV gain 25217958
dgv1233n100 CNV gain 25217958
nsv1040996 CNV gain 25217958
nsv1044491 CNV gain 25217958
nsv1047361 CNV gain 25217958
nsv825998 CNV gain 20364138

Variation tolerance for OMP Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OMP Gene

Human Gene Mutation Database (HGMD)
OMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene

Disorders for OMP Gene

MalaCards: The human disease database

(8) MalaCards diseases for OMP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epiglottitis
  • acute epiglottitis
haemophilus influenzae
  • h. influenzae
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerve
typhoid fever
  • typhoid
olfactory nerve neoplasm
  • neoplasm of olfactory nerve
- elite association - COSMIC cancer census association via MalaCards
Search OMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for OMP

Genetic Association Database (GAD)
OMP
Human Genome Epidemiology (HuGE) Navigator
OMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OMP
genes like me logo Genes that share disorders with OMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMP Gene

Publications for OMP Gene

  1. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PMID: 8034318) Buiakova O.I. … Margolis F.L. (Genomics 1994) 3 4 22 64
  2. Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans K.L. … Brown S.D. (Hum. Mol. Genet. 1993) 2 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody. (PMID: 19915959) Bagchi A.K. … Mukherjee J. (Mol. Cell. Biochem. 2010) 22 64

Products for OMP Gene

Sources for OMP Gene

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