OMP Gene
protein-coding GIFtS: 44
GCID: GC11P076813
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|
olfactory marker protein
| |
Aliases
for OMP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Marker Protein1 2 | | Olfactory Neuronal-Specific Protein2 3 |
Export aliases for OMP gene to outside databasesPrevious GC identifers: GC11P079140 GC11P078352 GC11P077036 GC11P076540 GC11P076491 |
Summaries
for OMP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OMP:
Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate speciesfrom fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human.Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odorstimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: OMP_HUMAN, P47874Function: May act as a modulator of the olfactory signal-transduction cascade
|
Genomic Views
for OMP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OMP gene promoter:
Max1 NF-1 NF-1/L FOXF2 NF-kappaB NF-kappaB1 C/EBPalpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for OMP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q14-q21OMP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P076813: view genomic region
(about GC identifiers)
Start:
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76,813,886 bp from pter |
End:
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76,814,377 bp from pter |
Size:
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492 bases |
Orientation:
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plus strand |
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Proteins
for OMP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OMP_HUMAN, P47874 (See
protein sequence)Recommended Name: Olfactory marker protein Size: 163 amino acids; 18937 Da
Subunit: Interacts with BEX1 and BEX2 (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q562G2Explore the universe of human proteins at neXtProt for OMP: NX_P47874
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P47874
OMP Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_006180.1
ENSEMBL proteins: ENSP00000436376
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
OMP for ontologies About GeneDecksing
OMP Antibody Products:
Assay Products for OMP: |
Protein
Domains /
Families
for OMP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OMP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P47874ProtoNet protein and cluster: P47874 1 Blocks protein family: IPB009103 Olfactory marker protein
UniProtKB/Swiss-Prot: OMP_HUMAN, P47874Similarity: Belongs to the olfactory marker protein family |
Function
for OMP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OMP_HUMAN, P47874Function: May act as a modulator of the olfactory signal-transduction cascade Genatlas biochemistry entry for OMP:olfactory marker protein, G protein coupled receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OMP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OMP (NM_000095) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OMP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004871 | signal transducer activity |
IEA | -- |
OMP for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Omptm1Flm for OMP
10 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Omp):
OMP for phenotypes About GeneDecksing
|
Pathways & Interactions
for OMP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OMP
2 Interacting proteins for OMP (P478743) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
OMP for ontologies About GeneDecksing
|
Drugs & Compounds
for OMP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
OMP for compounds About GeneDecksing
 Browse Tocris compounds for OMP
10/14 Novoseek chemical compound relationships for OMP gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| flagellin |
46.3 |
5 |
7622208 (1), 9629986 (1), 20455395 (1), 7917219 (1) |
| imipenem |
45.6 |
13 |
1761444 (4), 8006932 (1), 20424311 (1), 8641311 (1) (see all 5) |
| polysaccharide |
34.2 |
2 |
2129147 (1), 1716291 (1) |
| ceftazidime |
28.7 |
2 |
8641311 (2) |
| cefuroxime |
19.9 |
2 |
9350215 (2) |
| agarose |
18.8 |
2 |
12895340 (1), 15182624 (1) |
| protoporphyrin ix |
15.1 |
4 |
1331700 (1) |
| peptidoglycan |
5.28 |
2 |
1956287 (2) |
| iron |
1.4 |
18 |
1331700 (3), 16152669 (2), 8167428 (1), 20424311 (1) (see all 6) |
| ciprofloxacin |
0.878 |
5 |
9350215 (2), 8641311 (2), 19232480 (1) |
Search CenterWatch for drugs/clinical trials and news about OMP
|
Transcripts
for OMP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OMP gene: NM_006189.1 Unigene Cluster for OMP: Olfactory marker protein Hs.673853 Unigene Representative Sequence: EL7361941 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000529803(uc010rsk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OMP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OMP (NM_000095) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OMP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMP |
Additional cDNA sequence: BC069115.1 BC069365.1 1 DOTS entry: DT.91697187 3 AceView cDNA sequences: NM_006189 BC069365 BC069115
GeneLoc Exon Structure
|
Expression
for OMP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OMP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTTCCTCG
About this image
Genevestigator expression for OMP
SOURCE GeneReport for Unigene cluster: Hs.673853
UniProtKB/Swiss-Prot: OMP_HUMAN, P47874Tissue specificity: Uniquely associated with mature olfactory receptor neurons
SABiosciences Custom PCR Arrays for OMP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OMP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMP |
Orthologs
for OMP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OMP gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for OMP (if available)
TreeFam Gene Tree for OMP (if available) |
Paralogs
for OMP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OMP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): OMP
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OMP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OMP for disorders About GeneDecksing
OMIM gene information: 164340
OMIM disorders: --
20/28  diseases for OMP (see all 28): About MalaCardstyphoid fever usher syndrome type i usher syndrome epiglottitis
chronic obstructive pulmonary disease ankylosing spondylitis haemophilus influenzae klebsiella
leptospirosis cystic fibrosis reactive arthritis legionnaires' disease
neuronitis spondylitis gastroduodenitis meningitis
influenza pulmonary disease cholera periodontitis
10/18 Novoseek disease relationships for OMP gene (see all 18) About this table
Human Genome Epidemiology (HuGE) Navigator: OMP (102 documents)
Export disorders for OMP gene to outside databases
|
Publications
for OMP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OMP gene, integrated from 9 sources (see all 142):
(articles sorted by number of sources associating them with OMP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PubMed id 8034318)1, 2, 9 Buiakova O.I.... Margolis F.L. (1994)
- Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PubMed id 8499899)1, 3, 9 Evans K.L....Brown S.D. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. (PubMed id 12911636)1 Behrens M....Margolis F.L. (2003)
- Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction. (PubMed id 12054873)1 Baldisseri D.M....Margolis F.L. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. (PubMed id 8790421)1 Buiakova O.I....Margolis F.L. (1996)
|
External Searches for OMP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OMP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OMP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OMP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OMP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OMP gene:
Search GeneIP for patents involving OMP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OMP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OMP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OMP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OMP | | | OriGene Protein Over-expression Lysate for OMP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OMP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OMP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OMP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OMP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OMP | | OriGene Custom Protein Services for OMP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OMP | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OMP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OMP |
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| | | | Search Tocris compounds for OMP |
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 | | | OMP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for OMP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMP |
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