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OMP Gene(Protein Coding)

Olfactory Marker Protein

GCID:
GC11P077102
GIFtS:
46
Genes Participants
UDN Logo

Aliases for OMP Gene

Aliases for OMP Gene

  • Olfactory Marker Protein 2 3 5
  • Olfactory Neuronal-Specific Protein 4

External Ids for OMP Gene

Previous GeneCards Identifiers for OMP Gene

  • GC11P079140
  • GC11P078352
  • GC11P077036
  • GC11P076540
  • GC11P076491
  • GC11P076813

Summaries for OMP Gene

Entrez Gene Summary for OMP Gene

  • Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for OMP Gene

OMP (Olfactory Marker Protein) is a Protein Coding gene. Diseases associated with OMP include Epiglottitis and Haemophilus Influenzae. Gene Ontology (GO) annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for OMP Gene

  • May act as a modulator of the olfactory signal-transduction cascade.

Additional gene information for OMP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMP Gene

Genomics for OMP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OMP Gene

Promoters and enhancers for OMP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I077102 Promoter 0.5 EPDnew 550.8 +0.1 71 0.1 OMP MYO7A CAPN5
GH11I077034 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 12 -67.1 -67072 3.2 PKNOX1 FOXA2 MLX NFIB ZFP64 NEUROD1 RARA SCRT2 FOS RCOR1 B3GNT6 OMP MYO7A ACER3 CAPN5 LOC105369399
GH11I077045 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 -55.8 -55751 2.6 PKNOX1 ARID4B SIN3A YY1 ELK1 ARID2 ZNF143 ATF7 RUNX3 RXRA LOC105369399 OMP CAPN5 B3GNT6
GH11I077139 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 +38.1 38060 2.4 MAX SIN3A ZMYM3 ZIC2 GATA3 ZBTB48 POLR2A PRDM10 ATF7 FOS OMP GDPD4 ENSG00000254632 MYO7A PIR53181
GH11I077039 Enhancer 0.7 Ensembl ENCODE 11.8 -62.8 -62809 1.4 CTCF USF1 MAX ZNF143 ZBTB33 RAD21 EZH2 OMP MYO7A ACER3 LOC105369399 B3GNT6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OMP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OMP gene promoter:

Genomic Locations for OMP Gene

Genomic Locations for OMP Gene
chr11:77,102,840-77,103,331
(GRCh38/hg38)
Size:
492 bases
Orientation:
Plus strand
chr11:76,813,886-76,814,377
(GRCh37/hg19)

Genomic View for OMP Gene

Genes around OMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OMP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OMP Gene

Proteins for OMP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47874-OMP_HUMAN
    Recommended name:
    Olfactory marker protein
    Protein Accession:
    P47874
    Secondary Accessions:
    • Q562G2

    Protein attributes for OMP Gene

    Size:
    163 amino acids
    Molecular mass:
    18937 Da
    Quaternary structure:
    • Interacts with BEX1 and BEX2.

neXtProt entry for OMP Gene

Protein Expression for OMP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OMP Gene

No Post-translational modifications

Other Protein References for OMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OMP Gene

Domains & Families for OMP Gene

Gene Families for OMP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47874

UniProtKB/Swiss-Prot:

OMP_HUMAN :
  • Belongs to the olfactory marker protein family.
Family:
  • Belongs to the olfactory marker protein family.
genes like me logo Genes that share domains with OMP: view

Function for OMP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OMP Gene

GENATLAS Biochemistry:
olfactory marker protein, G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
May act as a modulator of the olfactory signal-transduction cascade.

Gene Ontology (GO) - Molecular Function for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with OMP: view
genes like me logo Genes that share phenotypes with OMP: view

Animal Models for OMP Gene

MGI Knock Outs for OMP:
  • Omp tm1Mom
  • Omp tm1Flm
  • Omp tm1.1(COP4*/EYFP)Tboz
  • Omp tm2(spH)Mom
  • Omp tm3Mom

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OMP Gene

Localization for OMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OMP gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IBA --
GO:0030424 axon IEA,IBA --
GO:0043025 neuronal cell body IEA,IBA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OMP Gene

Pathways & Interactions for OMP Gene

SuperPathways for OMP Gene

PathCards logo More details on SuperPathways for OMP
No Data Available

Interacting Proteins for OMP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000436376%0d%0a9606.ENSP00000442521%0d%0a9606.ENSP00000361813%0d%0a9606.ENSP00000308928%0d%0a
Selected Interacting proteins: ENSP00000436376 P47874-OMP_HUMAN for OMP Gene via STRING IID

Gene Ontology (GO) - Biological Process for OMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA,TAS --
GO:0007268 chemical synaptic transmission TAS 8790421
GO:0007608 sensory perception of smell IBA,TAS --
GO:0022008 neurogenesis IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OMP: view

No data available for Pathways by source and SIGNOR curated interactions for OMP Gene

Drugs & Compounds for OMP Gene

Products:

  1. Drug

(11) Drugs for OMP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for OMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OMP: view

Transcripts for OMP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OMP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OMP Gene

Olfactory marker protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OMP Gene

No ASD Table

Relevant External Links for OMP Gene

GeneLoc Exon Structure for
OMP
ECgene alternative splicing isoforms for
OMP

Expression for OMP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OMP Gene

mRNA expression in normal human tissues for OMP Gene
mRNA expression by GTEx for OMP GenemRNA expression by BioGPS for OMP Gene

mRNA differential expression in normal tissues according to GTEx for OMP Gene

This gene is overexpressed in Colon - Transverse (x10.1), Liver (x5.9), and Small Intestine - Terminal Ileum (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMP Gene



Protein tissue co-expression partners for OMP Gene

NURSA nuclear receptor signaling pathways regulating expression of OMP Gene:

OMP

SOURCE GeneReport for Unigene cluster for OMP Gene:

Hs.673853

mRNA Expression by UniProt/SwissProt for OMP Gene:

P47874-OMP_HUMAN
Tissue specificity: Uniquely associated with mature olfactory receptor neurons.

Evidence on tissue expression from TISSUES for OMP Gene

  • Lung(2.6)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with OMP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OMP Gene

Orthologs for OMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OMP 33 34
  • 98.57 (n)
dog
(Canis familiaris)
 Mammalia OMP 33
  • 90.18 (n)
rat
(Rattus norvegicus)
 Mammalia Omp 33
  • 89.98 (n)
mouse
(Mus musculus)
 Mammalia Omp 33 16 34
  • 88.55 (n)
cow
(Bos Taurus)
 Mammalia OMP 33
  • 87.12 (n)
chicken
(Gallus gallus)
 Aves OMP 33
  • 65.56 (n)
lizard
(Anolis carolinensis)
 Reptilia OMP 34
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia omp 33
  • 64.41 (n)
zebrafish
(Danio rerio)
 Actinopterygii ompb 33 34
  • 61.97 (n)
ompa 34
  • 51 (a)
 OneToMany
Species where no ortholog for OMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMP Gene

ENSEMBL:
Gene Tree for OMP (if available)
TreeFam:
Gene Tree for OMP (if available)

Paralogs for OMP Gene

No data available for Paralogs for OMP Gene

Variants for OMP Gene

Sequence variations from dbSNP and Humsavar for OMP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000267923 -- 77,101,079(+) C/T upstream_transcript_variant
rs1002279500 -- 77,103,467(+) C/T downstream_transcript_variant
rs1006840813 -- 77,101,159(+) G/A upstream_transcript_variant
rs1007136996 -- 77,101,579(+) T/G upstream_transcript_variant
rs1008852038 -- 77,103,501(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OMP Gene

Variant ID Type Subtype PubMed ID
dgv1230n100 CNV gain 25217958
dgv1231n100 CNV gain 25217958
dgv1232n100 CNV gain 25217958
dgv1233n100 CNV gain 25217958
nsv1040996 CNV gain 25217958
nsv1044491 CNV gain 25217958
nsv1047361 CNV gain 25217958
nsv825998 CNV gain 20364138

Variation tolerance for OMP Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OMP Gene

Human Gene Mutation Database (HGMD)
OMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMP Gene

Disorders for OMP Gene

MalaCards: The human disease database

(11) MalaCards diseases for OMP Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epiglottitis
  • acute epiglottitis
haemophilus influenzae
  • h. influenzae
typhoid fever
  • typhoid
neisseria meningitidis infection
  • meningococcal disease
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerve
- elite association - COSMIC cancer census association via MalaCards
Search OMP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OMP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMP Gene

Publications for OMP Gene

  1. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PMID: 8034318) Buiakova OI … Margolis FL (Genomics 1994) 3 4 22 58
  2. Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I. (PMID: 8499899) Evans KL … Brown SD (Human molecular genetics 1993) 2 3 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody. (PMID: 19915959) Bagchi AK … Mukherjee J (Molecular and cellular biochemistry 2010) 22 58

Products for OMP Gene

Sources for OMP Gene

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