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Aliases for OMG Gene

Aliases for OMG Gene

  • Oligodendrocyte Myelin Glycoprotein 2 3
  • OMGP 3 4

External Ids for OMG Gene

Previous GeneCards Identifiers for OMG Gene

  • GC17P029688
  • GC17M031528
  • GC17M029471
  • GC17M029767
  • GC17M026645
  • GC17M029621
  • GC17M025832

Summaries for OMG Gene

GeneCards Summary for OMG Gene

OMG (Oligodendrocyte Myelin Glycoprotein) is a Protein Coding gene. Diseases associated with OMG include internuclear ophthalmoplegia and primary progressive multiple sclerosis. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for OMG Gene

  • Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system

Gene Wiki entry for OMG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMG Gene

Genomics for OMG Gene

Regulatory Elements for OMG Gene

Genomic Location for OMG Gene

Chromosome:
17
Start:
31,272,013 bp from pter
End:
31,297,539 bp from pter
Size:
25,527 bases
Orientation:
Minus strand

Genomic View for OMG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OMG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMG Gene

Proteins for OMG Gene

  • Protein details for OMG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23515-OMGP_HUMAN
    Recommended name:
    Oligodendrocyte-myelin glycoprotein
    Protein Accession:
    P23515
    Secondary Accessions:
    • E1P659

    Protein attributes for OMG Gene

    Size:
    440 amino acids
    Molecular mass:
    49608 Da
    Quaternary structure:
    • Binds to RTN4R.

neXtProt entry for OMG Gene

Proteomics data for OMG Gene at MOPED

Post-translational modifications for OMG Gene

  • O-glycosylated in its Ser/Thr-rich repeat domain.
  • Glycosylation at Asn 45, Asn 61, Asn 103, Asn 152, Asn 176, Asn 189, Asn 192, Asn 234, Asn 364, Asn 389, and Asn 425
  • Modification sites at PhosphoSitePlus

Other Protein References for OMG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OMG Gene

Domains & Families for OMG Gene

Suggested Antigen Peptide Sequences for OMG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23515

UniProtKB/Swiss-Prot:

OMGP_HUMAN :
  • Contains 1 LRRNT domain.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with OMG: view

No data available for Gene Families for OMG Gene

Function for OMG Gene

Molecular function for OMG Gene

GENATLAS Biochemistry:
oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system

Gene Ontology (GO) - Molecular Function for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with OMG: view

Phenotypes for OMG Gene

genes like me logo Genes that share phenotypes with OMG: view

Animal Models for OMG Gene

MGI Knock Outs for OMG:

Animal Model Products

miRNA for OMG Gene

miRTarBase miRNAs that target OMG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OMG Gene

Localization for OMG Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMG Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OMG Gene COMPARTMENTS Subcellular localization image for OMG gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with OMG: view

Pathways & Interactions for OMG Gene

genes like me logo Genes that share pathways with OMG: view

SIGNOR curated interactions for OMG Gene

Activates:

Gene Ontology (GO) - Biological Process for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0031102 neuron projection regeneration IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
GO:0048683 regulation of collateral sprouting of intact axon in response to injury IEA --
GO:0050770 regulation of axonogenesis TAS --
genes like me logo Genes that share ontologies with OMG: view

Drugs & Compounds for OMG Gene

No Compound Related Data Available

Transcripts for OMG Gene

mRNA/cDNA for OMG Gene

Unigene Clusters for OMG Gene

Oligodendrocyte myelin glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OMG Gene

No ASD Table

Relevant External Links for OMG Gene

GeneLoc Exon Structure for
OMG
ECgene alternative splicing isoforms for
OMG

Expression for OMG Gene

mRNA expression in normal human tissues for OMG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OMG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.7), Brain - Putamen (basal ganglia) (x4.6), Brain - Caudate (basal ganglia) (x4.5), Brain - Spinal cord (cervical c-1) (x4.4), Brain - Cortex (x4.3), Brain - Substantia nigra (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for OMG Gene

This gene is overexpressed in Frontal cortex (26.7), Brain (17.3), Spinal cord (7.9), and Cerebrospinal fluid (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMG Gene



SOURCE GeneReport for Unigene cluster for OMG Gene Hs.113874

mRNA Expression by UniProt/SwissProt for OMG Gene

P23515-OMGP_HUMAN
Tissue specificity: Oligodendrocytes and myelin of the central nervous system
genes like me logo Genes that share expression patterns with OMG: view

Protein tissue co-expression partners for OMG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for OMG Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OMG 35
  • 94.92 (n)
  • 94.77 (a)
OMG 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OMG 35
  • 95.91 (n)
  • 95.91 (a)
OMG 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Omg 35
  • 90.19 (n)
  • 89.02 (a)
Omg 16
Omg 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OMG 35
  • 99.7 (n)
  • 99.55 (a)
OMG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Omg 35
  • 90.34 (n)
  • 89.72 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia OMG 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves OMG 35
  • 65.61 (n)
  • 60.44 (a)
OMG 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OMG 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia omg 35
  • 53.71 (n)
  • 44.57 (a)
zebrafish
(Danio rerio)
Actinopterygii ogmb 36
  • 41 (a)
OneToMany
OMG (3 of 3) 36
  • 31 (a)
OneToMany
omga 36
  • 49 (a)
OneToMany
Species with no ortholog for OMG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMG Gene

ENSEMBL:
Gene Tree for OMG (if available)
TreeFam:
Gene Tree for OMG (if available)

Paralogs for OMG Gene

No data available for Paralogs for OMG Gene

Variants for OMG Gene

Sequence variations from dbSNP and Humsavar for OMG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_051252 -
VAR_051253 -

Structural Variations from Database of Genomic Variants (DGV) for OMG Gene

Variant ID Type Subtype PubMed ID
nsv833413 CNV Gain+Loss 17160897

Variation tolerance for OMG Gene

Residual Variation Intolerance Score: 33.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OMG Gene

HapMap Linkage Disequilibrium report
OMG
Human Gene Mutation Database (HGMD)
OMG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMG Gene

Disorders for OMG Gene

MalaCards: The human disease database

(7) MalaCards diseases for OMG Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
internuclear ophthalmoplegia
primary progressive multiple sclerosis
  • primary-progressive ms
dissociative disorder
  • dissociative disease
learning disability
  • learning disorder
autoimmune disease of the nervous system
  • autoimmune diseases nervous system
- elite association
Search OMG in MalaCards View complete list of genes associated with diseases

Relevant External Links for OMG

Genetic Association Database (GAD)
OMG
Human Genome Epidemiology (HuGE) Navigator
OMG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OMG
genes like me logo Genes that share disorders with OMG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMG Gene

Publications for OMG Gene

  1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PMID: 1899288) Viskochil D. … White R. (Mol. Cell. Biol. 1991) 2 23 67
  2. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PMID: 2277079) Mikol D.D. … Stefansson K. (J. Cell Biol. 1990) 2 23 67
  3. Aptamer antagonists of myelin-derived inhibitors promote axon growth. (PMID: 20300533) Wang Y. … Ellington A.D. (PLoS ONE 2010) 23 67
  4. Receptors for myelin inhibitors: Structures and therapeutic opportunities. (PMID: 19619659) Cao Z. … Walsh F.S. (Mol. Cell. Neurosci. 2010) 23 67
  5. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. (PMID: 19420245) Robak L.A. … Giger R.J. (J. Neurosci. 2009) 23 67

Products for OMG Gene

Sources for OMG Gene

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