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Aliases for OMG Gene

Aliases for OMG Gene

  • Oligodendrocyte Myelin Glycoprotein 2 3 5
  • OMGP 3 4
  • Oligodendrocyte-Myelin Glycoprotein 3

External Ids for OMG Gene

Previous GeneCards Identifiers for OMG Gene

  • GC17P029688
  • GC17M031528
  • GC17M029471
  • GC17M029767
  • GC17M026645
  • GC17M029621
  • GC17M025832

Summaries for OMG Gene

GeneCards Summary for OMG Gene

OMG (Oligodendrocyte Myelin Glycoprotein) is a Protein Coding gene. Diseases associated with OMG include Internuclear Ophthalmoplegia and Ectopic Thymus. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Spinal Cord Injury. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for OMG Gene

  • Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Gene Wiki entry for OMG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMG Gene

Genomics for OMG Gene

Regulatory Elements for OMG Gene

Enhancers for OMG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G031267 1.2 Ensembl ENCODE 25 +28.5 28467 3.3 HDGF ZNF133 ZFP64 SIN3A FEZF1 ZBTB7B GATA2 ZNF143 FOS ZNF263 OMG EVI2A NF1 RAB11FIP4 LOC101927057 GC17P031252 GC17P031255 GC17P031253
GH17G031306 1.7 FANTOM5 ENCODE dbSUPER 11.8 -13.3 -13282 9.5 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 EVI2A OMG RAB11FIP4 CRLF3 EVI2B ADAP2
GH17G031248 0.8 ENCODE 23.9 +47.0 46956 4.4 FOXA2 CEBPG FEZF1 EBF1 ZNF644 ZNF121 ZFHX2 POLR2A GATA2 SCRT2 OMG EVI2A NF1 RAB11FIP4 GC17P031252 GC17P031253 GC17P031255 GC17P031148
GH17G031272 0.6 FANTOM5 23 +24.8 24785 0.6 MAFF ZNF316 EMSY PRDM1 MAFK OMG EVI2A NF1 RAB11FIP4 LRRC37BP1 LOC101927057 GC17P031252 GC17P031253 GC17P031255
GH17G031273 1 Ensembl ENCODE 12.6 +23.0 22981 1.7 ELF3 SOX13 FOXA2 MAX CEBPG FEZF1 ZNF644 YY1 ZNF664 ZNF26 UTP6 OMG SUZ12 EVI2A NF1 TEFM ATAD5 LOC101927057 GC17P031252 GC17P031253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OMG on UCSC Golden Path with GeneCards custom track

Genomic Location for OMG Gene

Chromosome:
17
Start:
31,272,013 bp from pter
End:
31,297,539 bp from pter
Size:
25,527 bases
Orientation:
Minus strand

Genomic View for OMG Gene

Genes around OMG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OMG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OMG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMG Gene

Proteins for OMG Gene

  • Protein details for OMG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23515-OMGP_HUMAN
    Recommended name:
    Oligodendrocyte-myelin glycoprotein
    Protein Accession:
    P23515
    Secondary Accessions:
    • E1P659

    Protein attributes for OMG Gene

    Size:
    440 amino acids
    Molecular mass:
    49608 Da
    Quaternary structure:
    • Binds to RTN4R.

neXtProt entry for OMG Gene

Post-translational modifications for OMG Gene

  • O-glycosylated in its Ser/Thr-rich repeat domain.
  • Glycosylation at Asn45, posLast=6161, Asn103, posLast=152152, posLast=176176, Asn189, posLast=192192, Asn234, posLast=364364, posLast=389389, and Asn425
  • Modification sites at PhosphoSitePlus

Other Protein References for OMG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OMG

No data available for DME Specific Peptides for OMG Gene

Domains & Families for OMG Gene

Suggested Antigen Peptide Sequences for OMG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OMG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OMG Gene

Function for OMG Gene

Molecular function for OMG Gene

GENATLAS Biochemistry:
oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
genes like me logo Genes that share phenotypes with OMG: view

Animal Models for OMG Gene

MGI Knock Outs for OMG:

Animal Model Products

miRNA for OMG Gene

miRTarBase miRNAs that target OMG

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OMG Gene

Localization for OMG Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMG Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OMG gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with OMG: view

Pathways & Interactions for OMG Gene

genes like me logo Genes that share pathways with OMG: view

SIGNOR curated interactions for OMG Gene

Activates:

Gene Ontology (GO) - Biological Process for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007409 axonogenesis IBA --
GO:0050771 negative regulation of axonogenesis TAS --
genes like me logo Genes that share ontologies with OMG: view

Transcripts for OMG Gene

Unigene Clusters for OMG Gene

Oligodendrocyte myelin glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMG Gene

No ASD Table

Relevant External Links for OMG Gene

GeneLoc Exon Structure for
OMG
ECgene alternative splicing isoforms for
OMG

Expression for OMG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OMG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OMG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.7), Brain - Putamen (basal ganglia) (x4.6), Brain - Caudate (basal ganglia) (x4.5), Brain - Spinal cord (cervical c-1) (x4.4), Brain - Cortex (x4.3), Brain - Substantia nigra (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for OMG Gene

This gene is overexpressed in Frontal cortex (26.7), Brain (17.3), Spinal cord (7.9), and Cerebrospinal fluid (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMG Gene



Protein tissue co-expression partners for OMG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OMG Gene:

OMG

SOURCE GeneReport for Unigene cluster for OMG Gene:

Hs.113874

mRNA Expression by UniProt/SwissProt for OMG Gene:

P23515-OMGP_HUMAN
Tissue specificity: Oligodendrocytes and myelin of the central nervous system.

Evidence on tissue expression from TISSUES for OMG Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with OMG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OMG Gene

Orthologs for OMG Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OMG 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia OMG 34 35
  • 95.91 (n)
cow
(Bos Taurus)
Mammalia OMG 34 35
  • 94.92 (n)
rat
(Rattus norvegicus)
Mammalia Omg 34
  • 90.34 (n)
mouse
(Mus musculus)
Mammalia Omg 34 16 35
  • 90.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OMG 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves OMG 34 35
  • 65.61 (n)
lizard
(Anolis carolinensis)
Reptilia OMG 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia omg 34
  • 53.71 (n)
zebrafish
(Danio rerio)
Actinopterygii omga 35
  • 49 (a)
OneToMany
ogmb 35
  • 41 (a)
OneToMany
OMG (3 of 3) 35
  • 31 (a)
OneToMany
Species where no ortholog for OMG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMG Gene

ENSEMBL:
Gene Tree for OMG (if available)
TreeFam:
Gene Tree for OMG (if available)

Paralogs for OMG Gene

No data available for Paralogs for OMG Gene

Variants for OMG Gene

Sequence variations from dbSNP and Humsavar for OMG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000286742 -- 31,296,575(+) TTCTC(C/G)TTTAT intron-variant
rs1000343494 -- 31,296,209(+) CCTGA(A/G)CAGTC intron-variant, reference, synonymous-codon
rs1000746571 -- 31,297,371(+) AAGAG(C/G)TGCAC intron-variant, upstream-variant-2KB
rs1001963161 -- 31,294,375(+) AGAGC(C/T)TTTGT intron-variant
rs1002021814 -- 31,295,542(+) GTTAT(A/G)TTCCT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OMG Gene

Variant ID Type Subtype PubMed ID
nsv1061870 CNV loss 25217958
nsv833413 CNV gain+loss 17160897

Variation tolerance for OMG Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OMG Gene

Human Gene Mutation Database (HGMD)
OMG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OMG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMG Gene

Disorders for OMG Gene

MalaCards: The human disease database

(9) MalaCards diseases for OMG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
internuclear ophthalmoplegia
ectopic thymus
thymus gland disease
  • disease of thymus gland
neurofibromatosis
  • acoustic neurofibromatosis
primary progressive multiple sclerosis
  • ppms
- elite association - COSMIC cancer census association via MalaCards
Search OMG in MalaCards View complete list of genes associated with diseases

Relevant External Links for OMG

Genetic Association Database (GAD)
OMG
Human Genome Epidemiology (HuGE) Navigator
OMG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OMG
genes like me logo Genes that share disorders with OMG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMG Gene

Publications for OMG Gene

  1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PMID: 1899288) Viskochil D. … White R. (Mol. Cell. Biol. 1991) 2 3 4 22 64
  2. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PMID: 2277079) Mikol D.D. … Stefansson K. (J. Cell Biol. 1990) 2 3 4 22 64
  3. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PMID: 16425041) Venturin M. … Riva P. (Neurogenetics 2006) 3 22 46 64
  4. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. (PMID: 1688857) Mikol D.D. … Stefansson K. (J. Cell Biol. 1990) 3 4 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for OMG Gene

Sources for OMG Gene

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