OMG Gene
protein-coding GIFtS : 62
GCID: GC17 M029621
oligodendrocyte myelin glycoprotein
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Aliasesfor OMG gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Oligodendrocyte Myelin Glycoprotein 1 2 OMGP1 2 3 5 Oligodendrocyte-Myelin Glycoprotein2
Export aliases for OMG gene to outside databases Previous GC identifers: GC17P029688 GC17M031528 GC17M029471 GC17M029767 GC17M026645 GC17M025832
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Summariesfor OMG gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 Function : Cell adhesion molecule contributing to the interactive process required for myelination in the centralnervous system Gene Wiki entry for OMG
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Genomic Viewsfor OMG gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010799.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OMG gene promoter: AhR Sox5 HTF MyoD FOXD3 Arnt Evi-1 C/EBPalpha CHOP-10 Other transcription factors Search SABiosciences Chromatin IP Primers for OMG Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMG
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11-q12 OMG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M029621: view genomic region
(about GC identifiers )
Start:
29,599,031 bp from pter
End:
29,624,557 bp from pter
Size:
25,527 bases
Orientation:
minus strand
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Proteinsfor OMG gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 (See
protein sequence )Recommended Name: Oligodendrocyte-myelin glycoprotein precursor Size : 440 amino acids; 49608 Da
Subunit : Binds to RTN4R (By similarity)
Subcellular location : Cell membrane; Lipid-anchor, GPI-anchor
Caution : Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG)
Secondary accessions : E1P659Explore the universe of human proteins at neXtProt for OMG: NX_P23515 Post-translational modifications:
O-glycosylated in its Ser/Thr-rich repeat domain (Potential)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P23515 OMG Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002535.3 ENSEMBL proteins: ENSP00000247271 Reactome Protein details: P23515 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
TAS -- GO:0031225 anchored to membrane
IEA --
OMG for ontologies About GeneDecksing OMG Antibody Products: Assay Products for OMG:
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Protein
Domains / Familiesfor OMG gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OMG for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P23515 ProtoNet protein and cluster: P23515
2 Blocks protein families : IPB000372 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 Similarity : Contains 8 LRR (leucine-rich) repeatsSimilarity : Contains 1 LRRNT domain
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Functionfor OMG gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 Function : Cell adhesion molecule contributing to the interactive process required for myelination in the centralnervous system
Genatlas biochemistry entry for OMG : oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation) Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OMG (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OMGOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OMG (NM_002544 ) Sino Biological Human cDNA Clone for OMG DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OMG Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OMG
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMG
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0042802 identical protein binding
IEA --
OMG for ontologies About GeneDecksing Animal Models: Mouse knock-out Omg tm1.3Bzh for OMG 3 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Omg) :
OMG for phenotypes About GeneDecksing
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Pathways & Interactionsfor OMG gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Axonal growth inhibition (RHOA activation) 2 Development MAG-dependent inhibition of neurite outgrowth 3 p75(NTR)-mediated signaling 4 Cell death signalling via NRAGE, NRIF and NADE 5 Signaling by GPCR
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for OMG 1 GeneGo (Thomson Reuters) Pathway for OMG 1 BioSystems Pathway for OMG 5
Reactome Pathways for OMG
OMG for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OMG STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/8 Interacting proteins for OMG (P23515 3 ENSP00000247271 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007155 cell adhesion
IEA -- GO:0031102 neuron projection regeneration
IEA -- GO:0048011 nerve growth factor receptor signaling pathway
TAS -- GO:0048683 regulation of collateral sprouting of intact axon in response to injury
IEA -- GO:0050770 regulation of axonogenesis
TAS --
OMG for ontologies About GeneDecksing
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Drugs & Compoundsfor OMG gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OMG Search CenterWatch for drugs/clinical trials and news about OMG / OMGP
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Transcriptsfor OMG gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OMG gene: NM_002544.4 Unigene Cluster for OMG:
Oligodendrocyte myelin glycoprotein Hs.113874 [show with all ESTs ] Unigene Representative Sequence: NM_002544 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000584094 ENST00000580156 ENST00000582029 (uc021tuj.1 ) ENST00000247271 (uc002hgj.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OMG (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OMGOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: OMG (NM_002544 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OMG Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OMG
Additional cDNA sequence: AK222663.1 AK312445.1 BC018050.1 X51694.1
9 DOTS entries : DT.100774711 DT.411330
DT.100641361 DT.100774709 DT.120972915 DT.120973146 DT.97835512 DT.120972887 DT.97813773 24/93 AceView cDNA sequences (see all 93 ):
BC018050 BM969521 BM696502 NM_002544 BX102289 X51694 BM929852 AW592675 AI186954 BP346861 BQ340496 BI912883 BG700661 AA961459 BP362783 BG701812 BM979700 BU507756 BG546919 BI551796 BF507620 AV661099 BE704152 AI634885 GeneLoc Exon Structure
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Expression for OMG gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OMG expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGCTGTCT
About this image OMG expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Inner Nuclear Layer Mature Horizontal Cells Horizontal, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See OMG Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OMG SOURCE GeneReport for Unigene cluster: Hs.113874 UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 Tissue specificity : Oligodendrocytes and myelin of the central nervous system SABiosciences Custom PCR Arrays for OMG Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OMGBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat OMG QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OMG QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OMG In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMG
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Orthologsfor OMG gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for OMG gene from 4/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for OMG (if available)TreeFam Gene Tree for OMG (if available)
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Paralogsfor OMG gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor OMG gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OMG 1 CNV : 4999 Human Gene Mutation Database (HGMD) : OMG SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OMG
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Disorders
/ Diseasesfor OMG gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
OMG for disorders About GeneDecksing
OMIM gene information: 164345
OMIM disorders : --10 diseases for OMG : About MalaCards patulous eustachian tube internuclear ophthalmoplegia learning disability autistic disorder neurofibromatosis ophthalmoplegia multiple sclerosis retinitis schizophrenia neuronitis 2 diseases from the University of Copenhagen DISEASES database for OMG :Myasthenia gravis Neurofibromatosis 2 Novoseek disease relationships for OMG gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
neurofibromatosis type 1
61.5
1
8244377 (1)
scar
19.5
1
16646157 (1)
Genetic Association Database (GAD): OMG Human Genome Epidemiology (HuGE) Navigator: OMG (3 documents) Export disorders for OMG gene to outside databases
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Publicationsfor OMG gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OMG gene, integrated from 9 sources (see all 61 ): (articles sorted by number of sources associating them with OMG) Utopia : connect your pdf to the dynamic world of online information
The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PubMed id 1899288) 1 , 2 , 3, 9 Viskochil D.... White R. (1991) Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PubMed id 2277079) 1 , 2 , 3, 9 Mikol D.D....Stefansson K. (1990) The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. (PubMed id 1688857) 1 , 2 , 9 Mikol D.D.... Stefansson K. (1990) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (PubMed id 12566166) 1 , 4 Vourc'h P....Andres C. (2003) A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes. (PubMed id 3283151) 1 , 2 Mikol D.D. and Stefansson K. (1988) Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PubMed id 16425041) 1 , 9 Venturin M....Riva P. (2006) The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure. (PubMed id 8244377) 1 , 9 Mikol D.D....Stefansson K. (1993) The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (PubMed id 12692556) 1 , 9 Yamashita T. and Tohyama M. (2003) Learning disability and oligodendrocyte myelin glycop rotein (OMGP) gene in neurofibromatosis type 1. (PubMed id 21534343) 1 Terzi Y.K....Ayter S. (2011)
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External Searches for OMG gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OMG gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OMG gene
(According to HUGE )
About This Section --
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Specialized Databases showing OMG gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for OMG gene: Search GeneIP for patents involving OMG GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OMG gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for OMG OriGene shRNA RFP for OMG OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for OMG OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for OMG Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for OMG OriGene 3'-UTR Clone for OMG OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for OMG OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for OMG Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for OMG OriGene Custom Protein Services for OMG OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OMG QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing OMG QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMG QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat OMG QIAGEN QuantiFast Probe-based Assays in human , mouse , rat OMG QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat OMG
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OMG Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMG
ThermoFisher Antibodies for OMG
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat OMG
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Aliases for OMG
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Disorders / Diseases for OMG
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Drugs / Compounds for OMG
Expression for OMG
Function for OMG
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