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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OMG Gene

protein-coding   GIFtS: 62
GCID: GC17M029621

oligodendrocyte myelin glycoprotein

 Explore 10 diseases affiliated with
OMG via our new
 Human Malady Compendium 
Biological research products
for OMG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Oligodendrocyte Myelin Glycoprotein1 2
OMGP1 2 3 5
Oligodendrocyte-Myelin Glycoprotein2

External Ids:    HGNC: 81351   Entrez Gene: 49742   Ensembl: ENSG000001268617   OMIM: 1643455   UniProtKB: P235153   

Export aliases for OMG gene to outside databases

Previous GC identifers: GC17P029688 GC17M031528 GC17M029471 GC17M029767 GC17M026645 GC17M025832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515
Function: Cell adhesion molecule contributing to the interactive process required for myelination in the central
nervous system

Gene Wiki entry for OMG


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OMG gene promoter:
         AhR   Sox5   HTF   MyoD   FOXD3   Arnt   Evi-1   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOMG promoter sequence
   Search SABiosciences Chromatin IP Primers for OMG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11-q12

OMG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OMG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M029621:  view genomic region     (about GC identifiers)

Start:
29,599,031 bp from pter      End:
29,624,557 bp from pter
Size:
25,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515 (See protein sequence)
Recommended Name: Oligodendrocyte-myelin glycoprotein precursor  
Size: 440 amino acids; 49608 Da
Subunit: Binds to RTN4R (By similarity)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Caution: Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG)
Secondary accessions: E1P659

Explore the universe of human proteins at neXtProt for OMG: NX_P23515

Post-translational modifications:

  • O-glycosylated in its Ser/Thr-rich repeat domain (Potential)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23515

  • OMG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002535.3  
    ENSEMBL proteins: 
     ENSP00000247271  
    Reactome Protein details: P23515
    Human Recombinant Protein Products: 
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    Uscn Proteins for OMG

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0031225anchored to membrane IEA--


    OMG for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OMG


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OMG for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P23515

    ProtoNet protein and cluster: P23515

    2 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515
    Function: Cell adhesion molecule contributing to the interactive process required for myelination in the central
    nervous system

         Genatlas biochemistry entry for OMG:
    oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation)

    miRNA
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    hsa-miR-30c hsa-miR-561 hsa-miR-15a hsa-miR-503 hsa-miR-30d hsa-miR-497 hsa-miR-3617 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidOMG 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OMG (see all 7)
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    Gene Editing
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding IEA--


    OMG for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Omgtm1.3Bzh for OMG
         3 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Omg):
     homeostasis/metabolism  no phenotypic analysis  normal 

    OMG for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axonal growth inhibition (RHOA activation)
    Axonal growth inhibition (RHOA activation)1.00
    p75NTR regulates axonogenesis0.90
    2Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth1.00
    Development_MAG-dependent inhibition of neurite outgrowth0.87
    3p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling1.00
    4Cell death signalling via NRAGE, NRIF and NADE
    p75 NTR receptor-mediated signalling0.73
    5Signaling by GPCR
    Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for OMG
        Development MAG-dependent inhibition of neurite outgrowth


    1 GeneGo (Thomson Reuters) Pathway for OMG
        Development MAG-dependent inhibition of neurite outgrowth

    1 BioSystems Pathway for OMG 
        p75(NTR)-mediated signaling

    5        Reactome Pathways for OMG
        Axonal growth inhibition (RHOA activation)
    Signal Transduction
    p75NTR regulates axonogenesis
    Signalling by NGF
    p75 NTR receptor-mediated signalling



    OMG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OMG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for OMG (P235153 ENSP000002472714) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RTN4RQ9BZR63, ENSP000000434024I2D: score=1 STRING: ENSP00000043402
    RTN4RL1Q86UN23, ENSP000003306314I2D: score=1 STRING: ENSP00000330631
    YWHABP319463I2D: score=1 
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ARHGEF1ENSP000003372614STRING: ENSP00000337261
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0031102neuron projection regeneration IEA--
    GO:0048011nerve growth factor receptor signaling pathway TAS--
    GO:0048683regulation of collateral sprouting of intact axon in response to injury IEA--
    GO:0050770regulation of axonogenesis TAS--


    OMG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OMG
    Search CenterWatch for drugs/clinical trials and news about OMG / OMGP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OMG gene: 
    NM_002544.4  

    Unigene Cluster for OMG:

    Oligodendrocyte myelin glycoprotein
    Hs.113874  [show with all ESTs]
    Unigene Representative Sequence: NM_002544
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584094 ENST00000580156 ENST00000582029(uc021tuj.1) ENST00000247271(uc002hgj.3)


    miRNA
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    hsa-miR-30c hsa-miR-561 hsa-miR-15a hsa-miR-503 hsa-miR-30d hsa-miR-497 hsa-miR-3617 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidOMG 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OMG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMG

    Additional cDNA sequence: 

    AK222663.1 AK312445.1 BC018050.1 X51694.1 

    9 DOTS entries:

    DT.100774711  DT.411330  DT.100641361  DT.100774709  DT.120972915  DT.120973146  DT.97835512  DT.120972887 
    DT.97813773 

    24/93 AceView cDNA sequences (see all 93):

    BC018050 BM969521 BM696502 NM_002544 BX102289 X51694 BM929852 AW592675 
    AI186954 BP346861 BQ340496 BI912883 BG700661 AA961459 BP362783 BG701812 
    BM979700 BU507756 BG546919 BI551796 BF507620 AV661099 BE704152 AI634885 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OMG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCTGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    OMG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OMG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OMG

    SOURCE GeneReport for Unigene cluster: Hs.113874

    UniProtKB/Swiss-Prot: OMGP_HUMAN, P23515
    Tissue specificity: Oligodendrocytes and myelin of the central nervous system

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OMG gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Omg1 , 5 oligodendrocyte myelin glycoprotein1, 5 90.13(n)1
    88.84(a)1
      11 (46.79 cM)5
    183771  NM_019409.21  NP_062282.21 
     795009825 
    chicken
    (Gallus gallus)
    Aves OMG6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    19(9002622-9003926)
    lizard
    (Anolis carolinensis)
    Reptilia OMG6
    --
    50(a)
    1 ↔ 1
    GL343543.1(146731-148008)
    zebrafish
    (Danio rerio)
    Actinopterygii omga6
    BX000438.26
    --
    43(a)
    40(a)
    many → 1
    many → 1
    10(38667299-38670806)
    15(30215370-30221637)


    ENSEMBL Gene Tree for OMG (if available)
    TreeFam Gene Tree for OMG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OMG
         1 CNV: 4999
    Human Gene Mutation Database (HGMD): OMG
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OMG
    DNA2.0 Custom Variant and Variant Library Synthesis for OMG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OMG for disorders           About GeneDecksing

    OMIM gene information: 164345    OMIM disorders: --

    10 diseases for OMG:    About MalaCards
    patulous eustachian tube    internuclear ophthalmoplegia    learning disability    autistic disorder
    neurofibromatosis    ophthalmoplegia    multiple sclerosis    retinitis
    schizophrenia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for OMG:
    Myasthenia gravis     Neurofibromatosis

    2 Novoseek disease relationships for OMG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 61.5 1 8244377 (1)
    scar 19.5 1 16646157 (1)

    Genetic Association Database (GAD): OMG
    Human Genome Epidemiology (HuGE) Navigator: OMG (3 documents)

    Export disorders for OMG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OMG gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with OMG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PubMed id 1899288)1, 2, 3, 9 Viskochil D.... White R. (1991)
    2. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PubMed id 2277079)1, 2, 3, 9 Mikol D.D....Stefansson K. (1990)
    3. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. (PubMed id 1688857)1, 2, 9 Mikol D.D.... Stefansson K. (1990)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (PubMed id 12566166)1, 4 Vourc'h P....Andres C. (2003)
    6. A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes. (PubMed id 3283151)1, 2 Mikol D.D. and Stefansson K. (1988)
    7. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PubMed id 16425041)1, 9 Venturin M....Riva P. (2006)
    8. The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure. (PubMed id 8244377)1, 9 Mikol D.D....Stefansson K. (1993)
    9. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (PubMed id 12692556)1, 9 Yamashita T. and Tohyama M. (2003)
    10. Learning disability and oligodendrocyte myelin glycop rotein (OMGP) gene in neurofibromatosis type 1. (PubMed id 21534343)1 Terzi Y.K....Ayter S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4974 HGNC: 8135 AceView: OMG Ensembl:ENSG00000126861 euGenes: HUgn4974
    ECgene: OMG H-InvDB: OMG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OMG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OMG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OMG gene:
    Search GeneIP for patents involving OMG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
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