Aliases for OMD Gene
Aliases for OMD Gene
External Ids for OMD Gene
- HGNC: 8134
- Entrez Gene: 4958
- Ensembl: ENSG00000127083
- UniProtKB: Q99983
Previous GeneCards Identifiers for OMD Gene
- GC09M086003
- GC09M086904
- GC09M088475
- GC09M090517
- GC09M092256
- GC09M094216
- GC09M095176
- GC09M064853
Summaries for OMD Gene
GeneCards Summary for OMD Gene
OMD (Osteomodulin) is a Protein Coding gene. Diseases associated with OMD include Occult Macular Dystrophy and Hallermann-Streiff Syndrome. Among its related pathways are Defective CHST6 causes MCDC1 and Keratan sulfate/keratin metabolism. An important paralog of this gene is PRELP.
UniProtKB/Swiss-Prot for OMD Gene
-
May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMD Gene
Genomics for OMD Gene
GeneHancer (GH) Regulatory Elements for OMD Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09I092423 | Promoter/Enhancer | 1 | EPDnew ENCODE dbSUPER | 550.8 | -1.3 | -1341 | 4.4 | POLR2A | OMD CENPP NOL8 OGN ECM2 ASPN | |
GH09I092533 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 10.8 | -111.4 | -111408 | 4.3 | PKNOX1 FOXA2 TAF1 HLF EBF1 YY1 JUND GATA3 HNF4G HNF4A | ECM2 CENPP ASPN OMD OGN IPPK BICD2 MIR4670 | |
GH09I092359 | Enhancer | 0.4 | ENCODE | 12 | +64.9 | 64852 | 0.8 | RCOR1 DPF2 CHD2 | CENPP NOL8 OMD OGN LOC100420779 | |
GH09I092349 | Enhancer | 0.4 | Ensembl ENCODE | 11.5 | +74.1 | 74133 | 2.8 | CENPP NOL8 OMD FGD3 OGN LOC100420779 | ||
GH09I092377 | Enhancer | 0.3 | ENCODE | 11.9 | +46.0 | 46025 | 2.5 | FOXP2 | CENPP OGN OMD NOL8 LINC00475 LOC100420779 |
Regulatory Element Products
Genomic Locations for OMD Gene
- chr9:92,414,245-92,424,554
- (GRCh38/hg38)
- Size:
- 10,310 bases
- Orientation:
- Minus strand
- chr9:95,176,527-95,186,836
- (GRCh37/hg19)
Genomic View for OMD Gene
- Cytogenetic band:
-
- 9q22.31 by Ensembl
- 9q22.31 by Entrez Gene
- 9q22.31 by HGNC


RefSeq DNA sequence for OMD Gene
Proteins for OMD Gene
-
Protein details for OMD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99983-OMD_HUMAN
- Recommended name:
- Osteomodulin
- Protein Accession:
- Q99983
- Q5TBF4
Protein attributes for OMD Gene
- Size:
- 421 amino acids
- Molecular mass:
- 49492 Da
- Quaternary structure:
-
- Binds the alpha(V)beta(3)-integrin.
Protein Expression for OMD Gene
Post-translational modifications for OMD Gene
- Binds keratan sulfate chains.
- Glycosylation at Asn113, Asn121, Asn187, Asn242, and isoforms=316
Other Protein References for OMD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for OMD (Osteoadherin/OSAD)
-
Custom Antibody ServicesOriGene Antibodies for OMD
- Novus Biologicals Antibodies for OMD
-
Abcam antibodies for OMD
- Invitrogen Antibodies for OMD
- GeneTex OMD antibody for OMD
-
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Protein Products
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-
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- Sino Biological Cell Lysates for OMD
- Search GeneTex for Proteins for OMD
-
Abcam proteins for OMD
No data available for DME Specific Peptides for OMD Gene
Domains & Families for OMD Gene
Gene Families for OMD Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for OMD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OMD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99983UniProtKB/Swiss-Prot:
OMD_HUMAN :- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
- Family:
-
- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Function for OMD Gene
Molecular function for OMD Gene
- UniProtKB/Swiss-Prot Function:
- May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).
Phenotypes for OMD Gene
- MGI mutant phenotypes for OMD:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for OMD:
Animal Models for OMD Gene
- MGI Knock Outs for OMD:
-
- Omd tm1Lex
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for OMD gene
-
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- Search ViGene Biosciences for OMD
CRISPR Products
-
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- genomics-online: gRNA clones - Search results for available OMD gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for OMD Gene
- miRTarBase miRNAs that target OMD
-
- hsa-mir-6848-3p (MIRT535560)
- hsa-mir-6843-3p (MIRT535561)
- hsa-mir-6131 (MIRT535562)
- hsa-mir-3663-5p (MIRT535563)
- hsa-mir-372-5p (MIRT535564)
- hsa-mir-371a-5p (MIRT535565)
- hsa-mir-616-5p (MIRT535566)
- hsa-mir-373-5p (MIRT535567)
- hsa-mir-371b-5p (MIRT535568)
- hsa-mir-4726-3p (MIRT535569)
- hsa-mir-125a-3p (MIRT535570)
- hsa-mir-106a-3p (MIRT662840)
- hsa-mir-3652 (MIRT662841)
- hsa-mir-4430 (MIRT662842)
- hsa-mir-3622b-5p (MIRT662843)
- hsa-mir-122-5p (MIRT662844)
- hsa-mir-504-3p (MIRT662845)
- hsa-mir-3135b (MIRT662846)
- hsa-mir-454-3p (MIRT662847)
- hsa-mir-3666 (MIRT662848)
- hsa-mir-4295 (MIRT662849)
- hsa-mir-301b-3p (MIRT662850)
- hsa-mir-301a-3p (MIRT662851)
- hsa-mir-130b-3p (MIRT662852)
- hsa-mir-130a-3p (MIRT662853)
- hsa-mir-5197-5p (MIRT662854)
- hsa-mir-129-5p (MIRT783552)
- hsa-mir-190a-5p (MIRT784010)
- hsa-mir-190b (MIRT784014)
- hsa-mir-599 (MIRT787977)
- hsa-mir-8076 (MIRT789809)
miRNA Products
- Search ViGene Biosciences for OMD
Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available OMD gene related products
- orf clones - Search results for available OMD gene related products
- Applied Biological Materials Clones for OMD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem MEL2, NCr-fac Progenitor and PureStem SM30, NCr-fac & Meso-latp Progenitor for OMD
-
Horizon Cell Lines for OMD
-
ViGene Biosciences adenoviral particle packaged cDNA for OMD gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OMD Gene
Localization for OMD Gene
Subcellular locations from UniProtKB/Swiss-Prot for OMD Gene
- Secreted, extracellular space, extracellular matrix.
- Endoplasmic reticulum (2)
- Nucleoli fibrillar center (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005578 | proteinaceous extracellular matrix | IBA | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0031012 | extracellular matrix | IEA | -- |
Pathways & Interactions for OMD Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defective CHST6 causes MCDC1 | ||
2 | Keratan sulfate/keratin metabolism | ||
3 | Glycosaminoglycan metabolism | ||
4 | HIV Life Cycle |
.45
|
|
5 | Chondroitin sulfate/dermatan sulfate metabolism |
Pathways by source for OMD Gene
Interacting Proteins for OMD Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA | -- |
GO:0007409 | NOT axonogenesis | IBA | -- |
GO:0018146 | keratan sulfate biosynthetic process | TAS | -- |
GO:0030500 | regulation of bone mineralization | IEA | -- |
GO:0042340 | keratan sulfate catabolic process | TAS | -- |
Transcripts for OMD Gene
mRNA/cDNA for OMD Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for OMD
- genomics-online: gRNA clones - Search results for available OMD gene related products
- Applied Biological Materials CRISPR for OMD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OMD
- GenScript: Design CRISPR guide RNA sequences for OMD
miRNA Products
- Search ViGene Biosciences for OMD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for OMD
- Browse OriGene Inhibitory RNA Products For OMD
- genomics-online: shRNA clones - Search results for available OMD gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for OMD gene
Clone Products
- Sino Biological Human cDNA Clone for OMD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for OMD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OMD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available OMD gene related products
- orf clones - Search results for available OMD gene related products
- Applied Biological Materials Clones for OMD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for OMD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Lateral Plate Mesoderm (Gastrulation Derivatives)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for OMD Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMD Gene
NURSA nuclear receptor signaling pathways regulating expression of OMD Gene:
OMDSOURCE GeneReport for Unigene cluster for OMD Gene:
Hs.94070mRNA Expression by UniProt/SwissProt for OMD Gene:
Q99983-OMD_HUMANEvidence on tissue expression from TISSUES for OMD Gene
- Bone(4.4)
- Nervous system(4.3)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for OMD
-
OriGene qPCR primer pairs and template standards for OMD
- genomics-online: primer clones - Search results for available OMD gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OMD Gene
Orthologs for OMD Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | OMD 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | OMD 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | OMD 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Omd 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | OMD 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | OMD 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | OMD 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | omd 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for OMD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for OMD Gene
Variants for OMD Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000286336 | -- | 92,423,808(-) | C/T | intron_variant | |
rs1000711630 | -- | 92,422,787(-) | A/G | intron_variant | |
rs1001184149 | -- | 92,421,568(-) | G/A | intron_variant | |
rs1001223864 | -- | 92,416,016(-) | A/G | intron_variant | |
rs1001320171 | -- | 92,421,953(-) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3621079 | CNV | loss | 21293372 |
esv3891693 | CNV | gain | 25118596 |
nsv1047337 | CNV | loss | 25217958 |
nsv1049599 | CNV | loss | 25217958 |
nsv1053205 | CNV | loss | 25217958 |
Additional Variant Information for OMD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OMD
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMD Gene
Disorders for OMD Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
occult macular dystrophy |
|
|
hallermann-streiff syndrome |
|
|
Additional Disease Information for OMD
No data available for UniProtKB/Swiss-Prot and Genatlas for OMD Gene
Publications for OMD Gene
- The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors. (PMID: 19700767) Tillgren V … Heinegård D (The Journal of biological chemistry 2009) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. (PMID: 14551184) Onnerfjord P … Heinegård D (The Journal of biological chemistry 2004) 4 22 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro. (PMID: 12489179) Lucchini M … Farges JC (Connective tissue research 2002) 3 22 58
Products for OMD Gene
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- ESI BIO PureStem MEL2, NCr-fac Progenitor and PureStem SM30, NCr-fac & Meso-latp Progenitor for OMD
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for OMD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OMD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available OMD Antibodies ranked by validation data
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- antibodies-online: Search results for 8 available OMD Proteins ranked by validation data
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- GeneTex OMD antibody for OMD
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- Horizon Cell Lines for OMD
- genomics-online: cdna clones - Search results for available OMD gene related products
- orf clones - Search results for available OMD gene related products
- genomics-online: gRNA clones - Search results for available OMD gene related products
- genomics-online: primer clones - Search results for available OMD gene related products
- genomics-online: shRNA clones - Search results for available OMD gene related products
Sources for OMD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
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