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Aliases for OMD Gene

Aliases for OMD Gene

  • Osteomodulin 2 3
  • Keratan Sulfate Proteoglycan Osteomodulin 3 4
  • Osteoadherin Proteoglycan 2 3
  • KSPG Osteomodulin 3 4
  • SLRR2C 3 4
  • OSAD 3 4
  • Osteoadherin 4

External Ids for OMD Gene

Previous GeneCards Identifiers for OMD Gene

  • GC09M086003
  • GC09M086904
  • GC09M088475
  • GC09M090517
  • GC09M092256
  • GC09M094216
  • GC09M095176
  • GC09M064853

Summaries for OMD Gene

GeneCards Summary for OMD Gene

OMD (Osteomodulin) is a Protein Coding gene. Diseases associated with OMD include blepharospasm and aneurysmal bone cysts. Among its related pathways are Disease and Metabolism. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for OMD Gene

  • May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).

Gene Wiki entry for OMD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMD Gene

Genomics for OMD Gene

Regulatory Elements for OMD Gene

Genomic Location for OMD Gene

Start:
92,414,245 bp from pter
End:
92,424,554 bp from pter
Size:
10,310 bases
Orientation:
Minus strand

Genomic View for OMD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMD Gene

Proteins for OMD Gene

  • Protein details for OMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99983-OMD_HUMAN
    Recommended name:
    Osteomodulin
    Protein Accession:
    Q99983
    Secondary Accessions:
    • Q5TBF4

    Protein attributes for OMD Gene

    Size:
    421 amino acids
    Molecular mass:
    49492 Da
    Quaternary structure:
    • Binds the alpha(V)beta(3)-integrin.

neXtProt entry for OMD Gene

Proteomics data for OMD Gene at MOPED

Post-translational modifications for OMD Gene

Other Protein References for OMD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OMD Gene

Domains for OMD Gene

Gene Families for OMD Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

Suggested Antigen Peptide Sequences for OMD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99983

UniProtKB/Swiss-Prot:

OMD_HUMAN :
  • Q99983
Domain:
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with OMD: view

Function for OMD Gene

Molecular function for OMD Gene

UniProtKB/Swiss-Prot Function: May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).

Gene Ontology (GO) - Molecular Function for OMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OMD: view

Phenotypes for OMD Gene

MGI mutant phenotypes for OMD:
inferred from 1 alleles
GenomeRNAi human phenotypes for OMD:
genes like me logo Genes that share phenotypes with OMD: view

Animal Models for OMD Gene

MGI Knock Outs for OMD:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OMD Gene

Localization for OMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OMD Gene COMPARTMENTS Subcellular localization image for OMD gene
Compartment Confidence
extracellular 4
golgi apparatus 4
lysosome 4
vacuole 4
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005796 Golgi lumen TAS --
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with OMD: view

Pathways for OMD Gene

genes like me logo Genes that share pathways with OMD: view

Pathways by source for OMD Gene

Interacting Proteins for OMD Gene

Gene Ontology (GO) - Biological Process for OMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IEA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0042339 keratan sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with OMD: view

Compounds for OMD Gene

(1) HMDB Compounds for OMD Gene

Compound Synonyms Cas Number PubMed IDs
Keratan
  • Kerato sulfate
69992-87-6

(2) Novoseek inferred chemical compound relationships for OMD Gene

Compound -log(P) Hits PubMed IDs
leucine 36.5 2
tyrosine 11.1 2
genes like me logo Genes that share compounds with OMD: view

Transcripts for OMD Gene

mRNA/cDNA for OMD Gene

(69) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OMD Gene

Osteomodulin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OMD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMD Gene

No ASD Table

Relevant External Links for OMD Gene

GeneLoc Exon Structure for
OMD
ECgene alternative splicing isoforms for
OMD

Expression for OMD Gene

mRNA expression in normal human tissues for OMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OMD Gene

This gene is overexpressed in Artery - Aorta (9.7) and Artery - Coronary (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OMD Gene

SOURCE GeneReport for Unigene cluster for OMD Gene Hs.94070

mRNA Expression by UniProt/SwissProt for OMD Gene

Q99983-OMD_HUMAN
Tissue specificity: Bone specific
genes like me logo Genes that share expressions with OMD: view

In Situ Assay Products

Orthologs for OMD Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OMD 35
  • 99.45 (n)
  • 99.05 (a)
OMD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OMD 35
  • 88.86 (n)
  • 84.6 (a)
OMD 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OMD 35
  • 87.45 (n)
  • 84.22 (a)
OMD 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Omd 35
  • 85.39 (n)
  • 79.9 (a)
Omd 16
Omd 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OMD 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves OMD 35
  • 68.4 (n)
  • 61.54 (a)
OMD 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OMD 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii omd 35
  • 57.82 (n)
  • 51.69 (a)
omd 36
  • 47 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for OMD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMD Gene

ENSEMBL:
Gene Tree for OMD (if available)
TreeFam:
Gene Tree for OMD (if available)

Paralogs for OMD Gene

Paralogs for OMD Gene

Selected SIMAP similar genes for OMD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OMD: view

Variants for OMD Gene

Sequence variations from dbSNP and Humsavar for OMD Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
VAR_052014 -
VAR_052015 -
VAR_052016 -
VAR_052017 -
VAR_052018 -

Structural Variations from Database of Genomic Variants (DGV) for OMD Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294

Relevant External Links for OMD Gene

HapMap Linkage Disequilibrium report
OMD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMD Gene

Disorders for OMD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for OMD Gene including...

Search for OMD Gene in MalaCards »

(2) University of Copenhagen DISEASES for OMD Gene

genes like me logo Genes that share disorders with OMD: view

No data available for UniProtKB/Swiss-Prot for OMD Gene

Publications for OMD Gene

  1. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. (PMID: 14551184) Onnerfjord P. … Heinegaard D. (J. Biol. Chem. 2004) 4 23
  2. Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. (PMID: 10913920) Buchaille R. … Bleicher F. (Bone 2000) 3 23
  3. The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors. (PMID: 19700767) Tillgren V. … HeinegAYrd D. (J. Biol. Chem. 2009) 3 23
  4. TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro. (PMID: 12489179) Lucchini M. … Farges J.C. (Connect. Tissue Res. 2002) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for OMD Gene

Sources for OMD Gene

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