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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OMD Gene

protein-coding   GIFtS: 56
GCID: GC09M095176

Osteomodulin

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
osteomodulin1 2     SLRR2C2 3
Osteoadherin Proteoglycan1 2     KSPG Osteomodulin2 3
Keratan Sulfate Proteoglycan Osteomodulin2 3     Osteoadherin3
OSAD2 3     

External Ids:    HGNC: 81341   Entrez Gene: 49582   Ensembl: ENSG000001270837   UniProtKB: Q999833   

Export aliases for OMD gene to outside databases

Previous GC identifers: GC09M086003 GC09M086904 GC09M088475 GC09M090517 GC09M092256 GC09M094216 GC09M064853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OMD Gene: 
OMD (osteomodulin) is a protein-coding gene. Diseases associated with OMD include occult macular dystrophy, and meckel's diverticulum, and among its related super-pathways are Metabolism of carbohydrates and Keratan sulfate/keratin metabolism. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: OMD_HUMAN, Q99983
Function: May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the
alpha(V)beta(3)-integrin (By similarity)

Gene Wiki entry for OMD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OMD gene promoter:
         AP-1   ATF-2   FOXO3   FOXO3b   SRY   POU2F1   POU2F1a   FOXO3a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOMD promoter sequence
   Search SABiosciences Chromatin IP Primers for OMD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.31

OMD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OMD gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095176:  view genomic region     (about GC identifiers)

Start:
95,176,527 bp from pter      End:
95,186,836 bp from pter
Size:
10,310 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OMD_HUMAN, Q99983 (See protein sequence)
Recommended Name: Osteomodulin precursor  
Size: 421 amino acids; 49492 Da
Subunit: Binds the alpha(V)beta(3)-integrin (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q5TBF4

Explore the universe of human proteins at neXtProt for OMD: NX_Q99983

Explore proteomics data for OMD at MOPED 

Post-translational modifications:

  • UniProtKB: Binds keratan sulfate chains (By similarity)
  • View neXtProt modification sites for NX_Q99983

  • OMD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OMD Protein Expression
    REFSEQ proteins: NP_005005.1  
    ENSEMBL proteins: 
     ENSP00000364700  
    Reactome Protein details: Q99983
    Human Recombinant Protein Products for OMD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for OMD (Osteoadherin/OSAD)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OMD
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for OMD
    GenScript Custom Purified and Recombinant Proteins Services for OMD
    Novus Biologicals OMD Proteins
    Novus Biologicals OMD Lysates
    Sino Biological Recombinant Protein for OMD
    Sino Biological Cell Lysate for OMD 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OMD 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0043202lysosomal lumen TAS--

    OMD for ontologies           About GeneDecksing



    OMD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for OMD (Osteoadherin/OSAD)
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    Novus Biologicals OMD Antibodies
    Abcam antibodies for OMD
    Cloud-Clone Corp. Antibodies for OMD 
    ThermoFisher Antibody for OMD
    LSBio Antibodies in human, mouse, rat for OMD 

    Assay Products for OMD: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OMD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OMD 
    Cloud-Clone Corp. CLIAs for OMD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q99983

    ProtoNet protein and cluster: Q99983

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: OMD_HUMAN, Q99983
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    OMD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OMD_HUMAN, Q99983
    Function: May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the
    alpha(V)beta(3)-integrin (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    OMD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OMD:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Omd):
     behavior/neurological 

    OMD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Omdtm1Lex for OMD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OMD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OMD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OMD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OMD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OMD
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OMD:
    hsa-miR-576-5p hsa-miR-875-5p hsa-miR-3662 hsa-miR-578 hsa-miR-551b* hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidOMD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OMD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OMD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OMD
    Sirion Biotech Customized adenovirus for overexpression of OMD

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OMD (see all 7)
    OriGene ORF clones in mouse, rat for OMD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OMD (NM_005014)
    Sino Biological Human cDNA Clone for OMD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OMD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMD
    Sirion Biotech Customized lentivirus for stable overexpression of OMD 
                         Customized lentivirus expression plasmids for stable overexpression of OMD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OMD
    LifeMap BioReagents: cell lines associated with OMD: PureStem MEL2, NCr-fac Progenitor,
    PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OMD About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Keratan sulfate degradation0.38
    Keratan sulfate/keratin metabolism0.82
    3Metabolism
    Metabolism0.40
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/19        Reactome Pathways for OMD (see all 19)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome



    OMD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OMD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for OMD (ENSP000003647004) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FMODENSP000003470414STRING: ENSP00000347041
    KERAENSP000002667194STRING: ENSP00000266719
    LUMENSP000002667184STRING: ENSP00000266718
    OGNENSP000002625514STRING: ENSP00000262551
    PRELPENSP000003439244STRING: ENSP00000343924
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion IEA--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0042339keratan sulfate metabolic process TAS--

    OMD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OMD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OMD

    1 HMDB Compound for OMD    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--

    2 Novoseek inferred chemical compound relationships for OMD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 36.5 4 16970923 (1), 12704803 (1)
    tyrosine 11.1 2 19700767 (1), 14551184 (1)

    Search CenterWatch for drugs/clinical trials and news about OMD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OMD gene: 
    NM_005014.2  

    Unigene Cluster for OMD:

    Osteomodulin
    Hs.94070  [show with all ESTs]
    Unigene Representative Sequence: NM_005014
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375550(uc004asd.4)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OMD
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate OMD:
    hsa-miR-576-5p hsa-miR-875-5p hsa-miR-3662 hsa-miR-578 hsa-miR-551b* hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidOMD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OMD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OMD
    Clone
    Products:
         
    OriGene clones in human, mouse for OMD (see all 7)
    OriGene ORF clones in mouse, rat for OMD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OMD (NM_005014)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OMD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMD
    Sirion Biotech Customized lentivirus for stable overexpression of OMD 
                         Customized lentivirus expression plasmids for stable overexpression of OMD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OMD
    OriGene qSTAR qPCR primer pairs in human, mouse for OMD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OMD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OMD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMD

    Additional mRNA sequence: 

    AB000114.1 AK225922.1 AK313055.1 AY358872.1 BC046356.1 

    5 DOTS entries:

    DT.121154232  DT.212266  DT.100812526  DT.100812527  DT.91720490 

    24/69 AceView cDNA sequences (see all 69):

    BP343015 CA413997 AI638243 CA414013 AI148952 AY358872 AI655497 BC046356 
    N30894 BX097827 AI189981 AU117423 AI655516 AU119451 AI952953 BG900613 
    AA453328 AI989443 CA397539 BI522775 CA774638 AI138710 Z30156 AW978810 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OMD expression in normal human tissues (normalized intensities)      OMD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OMD Expression
    About this image


    OMD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 15 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Normal Human Articular chondrocytes (NHAC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 15 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle

    See OMD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OMD

    SOURCE GeneReport for Unigene cluster: Hs.94070

    UniProtKB/Swiss-Prot: OMD_HUMAN, Q99983
    Tissue specificity: Bone specific

        SABiosciences Custom PCR Arrays for OMD
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OMD gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Omd1 , 5 osteomodulin1, 5 85.65(n)1
    80.14(a)1
      13 (25.33 cM)5
    270471  NM_012050.21  NP_036180.11 
     495827665 
    chicken
    (Gallus gallus)
    Aves OMD6
    osteomodulin
    58(a)
    1 ↔ 1
    12(3409133-3419427)
    lizard
    (Anolis carolinensis)
    Reptilia OMD6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    2(156204671-156222543)
    zebrafish
    (Danio rerio)
    Actinopterygii omd1 osteomodulin 57.12(n)
    50.26(a)
      557913  XM_681068.1  XP_686160.1 


    ENSEMBL Gene Tree for OMD (if available)
    TreeFam Gene Tree for OMD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OMD gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LUM2  
    4 SIMAP similar genes for OMD using alignment to 1 protein entry:     OMD_HUMAN:
    KERA    LUM    PRELP    FMOD

    OMD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    5 SNPs in OMD are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0520154
    ----see VAR_0520152 E G mis40--------
    VAR_0520174
    ----see VAR_0520172 I T mis40--------
    VAR_0520144
    ----see VAR_0520142 D G mis40--------
    VAR_0520164
    ----see VAR_0520162 S N mis40--------
    VAR_0520184
    ----see VAR_0520182 C W mis40--------

    HapMap Linkage Disequilibrium report for OMD (95176527 - 95186836 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OMD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893573CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OMD
    DNA2.0 Custom Variant and Variant Library Synthesis for OMD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    8 diseases for OMD:    About MalaCards
    occult macular dystrophy    meckel's diverticulum    hallermann-streiff syndrome    aneurysmal bone cysts
    blepharospasm    morquio syndrome b    dental caries    parkinson's disease

    2 diseases from the University of Copenhagen DISEASES database for OMD:
    Blepharospasm     Parkinson's disease

    OMD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for OMD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OMD gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with OMD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. (PubMed id 10913920)1, 9 Buchaille R....Bleicher F. (2000)
    4. TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro. (PubMed id 12489179)1, 9 Lucchini M....Farges J.C. (2002)
    5. The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of he parin-binding proteins, including bioactive factors. (PubMed id 19700767)1, 9 Tillgren V....HeinegAYrd D. (2009)
    6. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. (PubMed id 14551184)2, 9 Onnerfjord P....Heinegard D. (2004)
    7. Immunodetection of osteoadherin in murine tooth extracellular matrices. (PubMed id 14673660)1 Couble M.L....Staquet M.J. (2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4958 HGNC: 8134 AceView: OMD Ensembl:ENSG00000127083 euGenes: HUgn4958
    ECgene: OMD H-InvDB: OMD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for OMD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OMD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OMD gene:
    Search GeneIP for patents involving OMD

    GeneCards and IP:
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