OMD Gene

Aliases
for OMD gene

Previous GC identifers: GC09M086003 GC09M086904 GC09M088475 GC09M090517 GC09M092256 GC09M094216 GC09M064853

Summaries
for OMD gene

Genomic Views
for OMD gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmid: OMD promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OMD

OMD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095176:  view genomic region     (about GC identifiers)

Proteins
for OMD gene

Explore the universe of human proteins at neXtProt for OMD: NX_Q99983

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for OMD (Osteoadherin/OSAD)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: OMD OriGene Custom Protein Services for OMD
	GenScript Custom Purified and Recombinant Proteins Services for OMD
	Novus Biologicals OMD Proteins Novus Biologicals OMD Lysates
	Sino Biological Recombinant Protein for OMD
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OMD

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for OMD (Osteoadherin/OSAD)
	Browse OriGene Antibodies OriGene Custom Antibody Services for OMD
	GenScript Custom Superior Antibodies Services for OMD
	Novus Biologicals OMD Antibodies
	Abcam antibodies for OMD
	Uscn Antibodies for OMD
	ThermoFisher Antibodies for OMD

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OMD
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OMD

Protein Domains /
Families
for OMD gene

ProtoNet protein and cluster: Q99983

Function
for OMD gene

Phenotypes:
     1 GenomeRNAi human phenotype for OMD:

(inferred from 1 allele) (MGI details for Omd)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OMD

miRNA Products:		OriGene 3'-UTR Clone: OMD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OMD
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate OMD:
		hsa-miR-576-5p hsa-miR-875-5p hsa-miR-3662 hsa-miR-578 hsa-miR-551b* hsa-miR-3144-3p
		SwitchGear 3'UTR luciferase reporter plasmid: OMD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OMD (see all 7) OriGene shRNA RFP: OMD OriGene siRNA: OMD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OMD
		Sirion Biotech Custom design and validation of potent shRNA sequences against OMD

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for OMD
			Sirion Biotech Customized adenovirus for overexpression of OMD  Sirion Biotech Customized adenovirus for potent knockdown of OMD

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OMD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OMD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OMD (NM_005014)
		Sino Biological Human cDNA Clone for OMD
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OMD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OMD
		LifeMap BioReagents: cell lines associated with OMD: PureStem MEL2, NCr-fac Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
		Sirion Biotech Customized stable knockdown cell line services for OMD  Sirion Biotech Customized inducible knockdown cell line services for OMD Sirion Biotech Customized stable overexpressing cell line services for OMD Sirion Biotech Customized inducible overexpressing cell line services for OMD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMD

Pathways & Interactions
for OMD gene

	Super-pathway	contained gene-specific pathways
1	MPS IIIC - Sanfilippo syndrome C	8/14 pathways (see all 14) MPS IIIC - Sanfilippo syndrome C 1.00 MPS IIIA - Sanfilippo syndrome A 1.00 MPS I - Hurler syndrome 1.00 MPS IIID - Sanfilippo syndrome D 1.00 Mucopolysaccharidoses 1.00 MPS IX - Natowicz syndrome 1.00 MPS IV - Morquio syndrome A 1.00 MPS II - Hunter syndrome 1.00
2	Extracellular KSPG translocates to the lysosome for degradation	Extracellular KSPG translocates to the lysosome for degradation 1.00 Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase 1.00 KSPG is secreted from the cell 1.00 Keratan sulfate degradation 0.58
3	Keratan sulfate biosynthesis	Keratan sulfate biosynthesis 1.00 Keratan sulfate/keratin metabolism 0.84
4	Disease	Disease 1.00
5	Metabolism	Metabolism 1.00

5/22        Reactome Pathways for OMD

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	Keratan sulfate/keratin metabolism
	MPS IIIA - Sanfilippo syndrome A

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for OMD gene

Transcripts
for OMD gene

Expression
for OMD gene

OMD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

OMD expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryPrimary FollicleGranulosa Cells			Ovary
	OvaryPrimordial FolliclePre-Granulosa Cells			Ovary
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)
	Name			Category
	PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	Micromass-induced chondrocytes (Micromass chondrogen...)			Bone, Cartilage
	HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage
	HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)			Adipose, Bone, Cartilage
	HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage
	HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)			Adipose
	HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)			Bone, Cartilage
	TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)			Bone, Cartilage

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OMD Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OMD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OMD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OMD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMD

Orthologs
for OMD gene

Paralogs
for OMD gene

Paralogs for OMD gene

OGN²  OPTC²  PODN²  PODNL1²  FMOD²  PRELP²  KERA²  ASPN²  

BGN²  DCN²  EPYC²  ECM2²  LUM²  

4 SIMAP similar genes for OMD using alignment to 1 protein entry:     OMD_HUMAN:

KERA    LUM    PRELP    FMOD

OMD for paralogs           About GeneDecksing

Genomic Variants
for OMD gene

10/199 NCBI SNPs in OMD are shown (see all 199)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1889364031,2		--	95176041(+)	TAGACA/GAATGA	2	--	int1 ds5001		0	--	--	--	--
rs727524631,2	C,F	--	95176103(+)	AGGTGG/AGCGTT	2	--	int1 ds5001		2		NA EA	240
rs1925353711,2		--	95176511(+)	TATTGA/GCTGAT	2	--	int1 ds5001		0	--	--	--	--
rs1827228591,2		--	95176563(+)	CCAACA/TCTAAT	2	--	ut31 int1		0	--	--	--	--
rs412786831,2	C	--	95176704(+)	TGCTGG/AAATCT	2	--	int1 ut31		1		NA	2
rs18029731,2		--	95176831(-)	CCAAGA/GCATAC	2	--	int1 ut31		0	--	--	--	--
rs412786851,2		--	95176841(+)	GGTCCG/TTAGTA	2	--	ut31 int1		0	--	--	--	--
rs1426041011,2		--	95176882(+)	CATTCG/TATGTG	2	--	ut31 int1		0	--	--	--	--
rs1874527531,2		--	95176976(+)	AGAAAA/GTGGTC	2	--	int1 ut31		0	--	--	--	--
rs109923271,2	C	--	95177044(+)	CCTCAA/GAGTGA	2	--	int1 ut31 ese3		0	--	--	--	--

HapMap Linkage Disequilibrium report for OMD (95176527 - 95186836 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for OMD: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OMD

DNA2.0 Custom Variant and Variant Library Synthesis for OMD

Disorders / Diseases
for OMD gene

Publications
for OMD gene

PubMed articles for OMD gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with OMD)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
3. Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. (PubMed id 10913920)^{1, 9} Buchaille R....Bleicher F. (2000)
4. TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro. (PubMed id 12489179)^{1, 9} Lucchini M....Farges J.C. (2002)
5. The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of he parin-binding proteins, including bioactive factors. (PubMed id 19700767)^{1, 9} Tillgren V....HeinegAYrd D. (2009)
6. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. (PubMed id 14551184)^{2, 9} Onnerfjord P....Heinegard D. (2004)
7. Immunodetection of osteoadherin in murine tooth extracellular matrices. (PubMed id 14673660)¹ Couble M.L....Staquet M.J. (2004)
8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

External Searches for OMD gene

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Products
for OMD gene