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OMA1 Gene

protein-coding   GIFtS: 44

GC01M058646
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
2010001O09Rik 2
DAB1 2
EC 3.4.24.- 3
FLJ33782 1, 2
MPRP-1 1, 2, 3
MPRP1 3
OTTHUMP00000011756 2
YKR087C 1, 2
ZMPOMA1 1, 2
Descriptions
Metalloprotease-related protein 1 3
OMA1 homolog, zinc metallopeptidase 2
OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 2
metalloprotease related protein 1 2
overlapping activity with M-AAA protease 2
External Ids
HGNC: 296611
Entrez Gene: 1152092
UniProtKB: Q96E523
Ensembl: ENSG000001626007
Search outside databases for aliases for OMA1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
Function: Mitochondrial protease (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OMA1 gene  

Entrez Gene cytogenetic band: 1p32.1   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32.2-p32.1

OMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M058646:     (about GC identifiers)

Start:
58,712,133 bp from pter
End:
58,785,040 bp from pter
Size:
72,908 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52 (See protein sequence)
Recommended Name: Metalloendopeptidase OMA1, mitochondrial precursor  
Size: 524 amino acids; 60120 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (Potential)
Caution: According to PubMed:12886954, it localizes in the endoplasmic reticulum. However, the
presence of a predicted transit peptide and the mitochondrial localization of orthologous protein
in fungi suggests that the endoplasmic reticulum localization is unsure
Sequence caution: Sequence=CAI13522.1; Type=Erroneous gene model prediction; Sequence=CAI13523.1;
Type=Erroneous gene model prediction; Sequence=CAI13524.1; Type=Erroneous gene model prediction;
Sequence=CAI13525.1; Type=Erroneous gene model prediction; Sequence=CAI13526.1; Type=Erroneous
gene model prediction; Sequence=CAI22238.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T3G6 Q5T3G7 Q5T3G8 Q5T3G9 Q5T3H0 Q8NBB3
Alternative splicing: 2 isoforms:  Q96E52-1   Q96E52-2   

REFSEQ proteins: NP_660286.1  

ENSEMBL proteins: 
ENSP00000351417 ENSP00000360270 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (OMA1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
GO:0031966 mitochondrial membrane IEA--
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Antibodies for OMA1: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for OMA1

Assays for OMA1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR006025 Pept_M_Zn_BS
 IPR001915 Peptidase_M48


   GeneDecks  OMA1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96E52

ProtoNet protein and cluster: Q96E52

UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
Similarity: Belongs to the peptidase M48 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OMA1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145243

              Applied Biosystems Silencer® siRNAs for OMA1

              Sigma-Aldrich siRNA for OMA1  
                     Sigma-Aldrich shRNA for OMA1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OMA1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145243
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145243
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_145243 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_145243

UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
Function: Mitochondrial protease (By similarity)
Enzyme Number (IUBMB): EC 3.4.24.- 

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004222 metalloendopeptidase activity IEA--
GO:0008233 peptidase activity IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006508 proteolysis IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OMA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OMA1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145243

              Sigma-Aldrich siRNA for OMA1  
                     Sigma-Aldrich shRNA for OMA1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_145243  

REFSEQ mRNAs for OMA1 gene: 

NM_145243.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_145243  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145243
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145243
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_145243 

Additional cDNA sequence: 

AB048348.1 AK091101.1 AK308847.1 BC012915.1 

10 DOTS entries:

DT.70101296  DT.211745  DT.100747189  DT.100747191  DT.95189009  DT.92034090  DT.121416413  DT.121416623 
DT.91712281  DT.121416439 

24/124 AceView cDNA sequences (see all 124 ):

AI653794 AA917760 BM710721 AA866176 AA975746 BF727432 CB306822 AW006192 
BX092419 N56690 H91670 BX452455 BX953300 AI572895 AI301592 AW948888 
AA465440 BM843631 BX096214 AI281005 AI732260 AA970751 Z39271 AK091101 

highest scoring ESTs for OMA1:

AB048348 AI927931 AL709798 BC012915 BG251645 BI667694 BU191827 BU568952 CB998878 T73861 

Unigene Cluster for OMA1:

OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
Hs.425769  [show with all ESTs]
Unigene Representative Sequence: AK091101


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000358603  ENST00000371226  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OMA1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OMA1

1 / 2 / 3

5 probe-sets matching OMA1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

48617_at2, 3 U95-C 2 0.44 0.88 1.00 1.00 AI927931 0.80 1.00 0.91 1

226019_at2, 3 U133-B 1 1.00 1.00 -- -- AI927931 0.80 1.00 0.91 1

226020_s_at2, 3 U133-B 2 1.00 0.50 -- -- AI927931 0.80 1.00 0.91 1

226019_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226020_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AAATATTGAT

SOURCE GeneReport for Unigene cluster: Hs.425769

UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
Tissue specificity: Widely expressed, with strong expression in the heart, skeletal muscle, kidney
and liver

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OMA1 gene from 5/11 species (see all 11 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OMA11   -- OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 86.39(n)
81.11(a)
489569  XM_546689.2  XP_546689.2 
cow
(Bos taurus)
OMA11   -- OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 86.23(n)
80.5(a)
506223  NM_001035033.1  NP_001030205.1 
rat
(Rattus norvegicus)
Oma11   -- OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 78.07(n)
72.8(a)
298282  XM_216446.4  XP_216446.3 
mouse
(Mus musculus)
Oma11, 5 45
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)1, 5 76.1(n)1
72.48(a)1
670131  NM_025909.21  NP_080185.11 
 AI0487005  AK0043735  (see all 11)
chicken
(Gallus gallus)
OMA11   -- OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 65.5(n)
58.39(a)
424670  XM_422503.2  XP_422503.2 
About this table        Species with no ortholog for OMA1

ENSEMBL Gene Tree for OMA1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/421 NCBI SNPs in OMA1 are shown (see all 421 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 189)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs75470361,2
A,C,F,H58786921(+) agggaT/Gacctt 1 -- ng314Minor allele frequency- G:0.36EU EA WA 418
rs11098961,2
C,F,H,O58784992(-) GGGTCG/TGCGGT 1 -- ut517Minor allele frequency- T:0.25EU EA MN NA 582
rs75138761,2
A,C,F,H58787020(+) tctggG/Tgtcct 1 -- ng314Minor allele frequency- T:0.16EU EA WA 406
rs11098951,2
C,F,H,O58785019(-) GTGCGA/GGTGCG 1 -- ut51 ese38Minor allele frequency- G:0.27EU EA WA MN NA 702
rs171176781,2
C,F,H58772239(+) TGCTAT/GTTCAT 1 L/I mis112Minor allele frequency- G:0.10NA EU EA WA 1060
rs127233411,2
C,F,H58785854(+) TCTTAT/CGTGTA 1 -- ng318Minor allele frequency- C:0.11EU EA WA NA 600
rs171176991,2
C,F,H58774870(+) GAGTAA/CAATAA 1 F/C mis1 ese315Minor allele frequency- C:0.07NA EU EA WA 1398
rs49123471,2
C,F,H58785279(+) CTACGG/ACAGTA 1 -- ng317Minor allele frequency- A:0.09EU EA WA NA 548
rs9029251,2
C,F,H58777567(+) CTTGAT/CTACCT 1 -- ut51 ese37Minor allele frequency- C:0.03NA EU EA WA 560
rs171177201,2
C,F,H58777205(+) GACTAG/AGGACT 1 L/P mis1 ese311Minor allele frequency- A:0.11NA EU EA WA 980
About this table

HapMap Linkage Disequilibrium images for OMA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for OMA1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 115209 HGNC: 29661 AceView: MPRP-1 Ensembl:ENSG00000162600 euGenes: HUgn115209
ECgene: OMA1 H-InvDB: OMA1
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OMA1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OMA1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OMA1 Browse small molecules at Sigma-Aldrich
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