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Aliases & Descriptions for OMA1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 2010001O09Rik 2 | | DAB1 2 | | EC 3.4.24.- 3 | | FLJ33782 1, 2 | | MPRP-1 1, 2, 3 | | MPRP1 3 | | OTTHUMP00000011756 2 | | YKR087C 1, 2 | | ZMPOMA1 1, 2 |
| | | Descriptions |
|---|
| Metalloprotease-related protein 1 3 | | OMA1 homolog, zinc metallopeptidase 2 | | OMA1 homolog, zinc metallopeptidase (S. cerevisiae) 2 | | metalloprotease related protein 1 2 | | overlapping activity with M-AAA protease 2 |
|
| | Search outside databases for aliases for OMA1 gene |
Summaries for OMA1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52Function: Mitochondrial protease (By similarity) |
Genomic Location for OMA1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OMA1 gene 
Entrez Gene cytogenetic band: 1p32.1 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p32.2-p32.1OMA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M058646:
(about GC identifiers)
Start:
|
58,712,133 bp from pter |
End:
|
58,785,040 bp from pter |
Size:
|
72,908 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for OMA1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52 (See
protein sequence)Recommended Name: Metalloendopeptidase OMA1, mitochondrial precursor Size: 524 amino acids; 60120 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (Potential)
Caution: According to PubMed:12886954, it localizes in the endoplasmic reticulum. However, the presence of a predicted transit peptide and the mitochondrial localization of orthologous protein in fungi suggests that the endoplasmic reticulum localization is unsure
Sequence caution: Sequence=CAI13522.1; Type=Erroneous gene model prediction; Sequence=CAI13523.1; Type=Erroneous gene model prediction; Sequence=CAI13524.1; Type=Erroneous gene model prediction; Sequence=CAI13525.1; Type=Erroneous gene model prediction; Sequence=CAI13526.1; Type=Erroneous gene model prediction; Sequence=CAI22238.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T3G6 Q5T3G7 Q5T3G8 Q5T3G9 Q5T3H0 Q8NBB3Alternative splicing: 2 isoforms: Q96E52-1 Q96E52-2 REFSEQ proteins: NP_660286.1
ENSEMBL proteins: ENSP00000351417 ENSP00000360270
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OMA1: Assays for OMA1: | Protein
Domains/ Families for OMA1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96E52
ProtoNet protein and cluster: Q96E52 UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52Similarity: Belongs to the peptidase M48 family | Gene Function for OMA1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145243
Applied Biosystems Silencer® siRNAs for OMA1
Sigma-Aldrich siRNA for OMA1  Sigma-Aldrich shRNA for OMA1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145243                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145243                                  untagged cDNA clones in CMV expression vector (see all 2): NM_145243 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_145243
UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52Function: Mitochondrial protease (By similarity)Enzyme Number (IUBMB): EC 3.4.24.- 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OMA1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | About this table
|
Drugs & Compounds for OMA1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OMA1
|
Transcripts for OMA1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145243
Sigma-Aldrich siRNA for OMA1  Sigma-Aldrich shRNA for OMA1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_145243 REFSEQ mRNAs for OMA1 gene: NM_145243.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_145243               OriGene GFP tagged cDNA clone in CMV expression vector: NM_145243                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145243                                  untagged cDNA clones in CMV expression vector (see all 2): NM_145243  Additional cDNA sequence: AB048348.1 AK091101.1 AK308847.1 BC012915.1 10 DOTS entries: DT.70101296 DT.211745 DT.100747189 DT.100747191 DT.95189009 DT.92034090 DT.121416413 DT.121416623 DT.91712281 DT.121416439 24/124 AceView cDNA sequences (see all 124
):AI653794 AA917760 BM710721 AA866176 AA975746 BF727432 CB306822 AW006192 BX092419 N56690 H91670 BX452455 BX953300 AI572895 AI301592 AW948888 AA465440 BM843631 BX096214 AI281005 AI732260 AA970751 Z39271 AK091101
highest scoring ESTs for OMA1:AB048348 AI927931 AL709798 BC012915 BG251645 BI667694 BU191827 BU568952 CB998878 T73861 Unigene Cluster for OMA1: OMA1 homolog, zinc metallopeptidase (S. cerevisiae) Hs.425769 [show with all ESTs]Unigene Representative Sequence: AK091101
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000358603
ENST00000371226
|
Expression for OMA1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OMA1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OMA1
1 / 2 / 3 5 probe-sets matching OMA1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAATATTGAT
SOURCE GeneReport for Unigene cluster: Hs.425769 UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52Tissue specificity: Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver |
Orthologs for OMA1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OMA1 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for OMA1
ENSEMBL Gene Tree for OMA1 | Paralogs for OMA1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for OMA1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OMA1 (up to first 250kb)
|
Disorders & Mutations for OMA1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for OMA1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OMA1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for OMA1 gene: |
Search for OMA1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OMA1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OMA1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OMA1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OMA1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OMA1:

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Incremental update: 13 Oct 2009
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