Aliases for OMA1 Gene
- OMA1 Zinc Metallopeptidase 2 3 5
- Overlapping With The M-AAA Protease 1 Homolog 3 4
- Overlapping Activity With M-AAA Protease 2 3
- Metalloprotease-Related Protein 1 3 4
- Zinc Metallopeptidase OMA1 2 3
- MPRP-1 3 4
- OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) 2
- OMA1 Homolog, Zinc Metallopeptidase 3
- OMA1 Zinc Metallopeptidase Homolog 3
External Ids for OMA1 Gene
Previous GeneCards Identifiers for OMA1 Gene
GeneCards Summary for OMA1 Gene
OMA1 (OMA1 Zinc Metallopeptidase) is a Protein Coding gene. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include metalloendopeptidase activity.
UniProtKB/Swiss-Prot for OMA1 Gene
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.