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OMA1 Gene

protein-coding   GIFtS: 48
GCID: GC01M058881

OMA1 Zinc Metallopeptidase

(Previous name: OMA1 zinc metallopeptidase homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
OMA1 Zinc Metallopeptidase1 2     YKR087C2
Overlapping Activity With M-AAA Protease1 2     ZMPOMA12
Zinc Metallopeptidase OMA11 2     Metalloendopeptidase OMA1, Mitochondrial2
Metalloprotease-Related Protein 12 3     Metalloprotease Related Protein 12
Overlapping With The M-AAA Protease 1 Homolog2 3     OMA1 Homolog, Zinc Metallopeptidase2
MPRP-12 3     OMA1 Zinc Metallopeptidase Homolog2
OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae)1     peptidase2
2010001O09Rik2     EC 3.4.24.-3
DAB12     MPRP13

External Ids:    HGNC: 296611   Entrez Gene: 1152092   Ensembl: ENSG000001626007   UniProtKB: Q96E523   

Export aliases for OMA1 gene to outside databases

Previous GC identifers: GC01M058646 GC01M058718 GC01M057056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OMA1 Gene:
OMA1 (OMA1 zinc metallopeptidase) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
Function: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria.
Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1
position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial
quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy
expenditure under cold-stress conditions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the OMA1 gene promoter:
         Elk-1   RP58   RFX1   Tal-1   POU3F1   CUTL1   STAT5A   E47   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOMA1 promoter sequence
   Search Chromatin IP Primers for OMA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.2-p32.1   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32.2-p32.1

OMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OMA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M058881:  view genomic region     (about GC identifiers)

Start:
58,881,056 bp from pter      End:
59,012,474 bp from pter
Size:
131,419 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52 (See protein sequence)
Recommended Name: Metalloendopeptidase OMA1, mitochondrial precursor  
Size: 524 amino acids; 60120 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Caution: Was initially reported to localize in the endoplasmic reticulum (PubMed:12886954). However, it was later
shown that it localizes to mitochondrion (PubMed:20038677)
Sequence caution: Sequence=BAC03583.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI13522.1; Type=Erroneous gene model prediction; Sequence=CAI13523.1; Type=Erroneous gene model
prediction; Sequence=CAI13524.1; Type=Erroneous gene model prediction; Sequence=CAI13525.1; Type=Erroneous gene
model prediction; Sequence=CAI13526.1; Type=Erroneous gene model prediction; Sequence=CAI22238.1; Type=Erroneous
gene model prediction;
Secondary accessions: D3DQ54 Q5T3G6 Q5T3G7 Q5T3G8 Q5T3G9 Q5T3H0 Q8NBB3
Alternative splicing: 2 isoforms:  Q96E52-1   Q96E52-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OMA1: NX_Q96E52

Explore proteomics data for OMA1 at MOPED

Post-translational modifications: 

  • In normal conditions, cleaved into an inactive 40 kDa form. Following CCCP treatment that induces loss of
    mitochondrial membrane potential, the 40 kDa form is reduced in favor of an active 60 kDa form1
  • Modification sites at neXtProt

  • See OMA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660286.1  
    ENSEMBL proteins: 
     ENSP00000391941   ENSP00000360270   ENSP00000395053   ENSP00000409589   ENSP00000416495  
     ENSP00000392978   ENSP00000474081   ENSP00000351417  

    OMA1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OMA1

     
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    antibodies-online peptides for OMA1

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    antibodies-online antibodies for OMA1 (7 products) 

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    Cloud-Clone Corp. ELISAs for OMA1
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001915 Peptidase_M48

    Graphical View of Domain Structure for InterPro Entry Q96E52

    ProtoNet protein and cluster: Q96E52

    UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
    Similarity: Belongs to the peptidase M48 family


    Find genes that share domains with OMA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OMA1_HUMAN, Q96E52
    Function: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria.
    Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1
    position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial
    quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy
    expenditure under cold-stress conditions

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IMP--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with OMA1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oma1):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     immune system  liver/biliary system 

    Find genes that share phenotypes with OMA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Oma1tm1Otin for OMA1

       genOway: Develop your customized and physiologically relevant rodent model for OMA1

    miRNA
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    miRTarBase miRNAs that target OMA1:
    hsa-mir-16-5p (MIRT000883), hsa-mir-125a-5p (MIRT021287), hsa-mir-15a-5p (MIRT000884), hsa-mir-10a-5p (MIRT025592)

    Block miRNA regulation of human, mouse, rat OMA1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate OMA1:
    hsa-miR-16-2* hsa-miR-195* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidOMA1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: OMA1 (NM_145243)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OMA1_HUMAN, Q96E52: Mitochondrion inner membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane3
    cytosol1
    extracellular1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IDA--

    Find genes that share ontologies with OMA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for OMA1
        Guidance Cues and Growth Cone Motility
    Reelin Pathway (Cajal-Retzius cells)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OMA1
    Interactions:

        Search GeneGlobe Interaction Network for OMA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for OMA1 (ENSP000003602704) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROMO1ENSP000003382934STRING: ENSP00000338293
    RCE1ENSP000003091634STRING: ENSP00000309163
    PFDN2ENSP000003569894STRING: ENSP00000356989
    ANKZF1ENSP000003216174STRING: ENSP00000321617
    SURF1ENSP000003610424STRING: ENSP00000361042
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002024diet induced thermogenesis IMP--
    GO:0006006glucose metabolic process IMP--
    GO:0006508proteolysis ----
    GO:0006515misfolded or incompletely synthesized protein catabolic process IMP--
    GO:0006629lipid metabolic process IMP--

    Find genes that share ontologies with OMA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OMA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OMA1 gene: 
    NM_145243.3  

    Unigene Cluster for OMA1:

    OMA1 zinc metallopeptidase homolog (S. cerevisiae)
    Hs.425769  [show with all ESTs]
    Unigene Representative Sequence: AK091101
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467509 ENST00000460671 ENST00000421528 ENST00000371226(uc001cyy.3)
    ENST00000476933 ENST00000456980 ENST00000467063 ENST00000419242 ENST00000426139
    ENST00000453710 ENST00000482274 ENST00000358603(uc001cyx.1 uc009vzz.3)

    miRNA
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    hsa-miR-16-2* hsa-miR-195* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidOMA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OMA1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OMA1 (NM_145243)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OMA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OMA1
    Primer
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    OriGene qPCR primer pairs and template standards for OMA1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OMA1
      QuantiTect SYBR Green Assays in human, mouse, rat OMA1
      QuantiFast Probe-based Assays in human, mouse, rat OMA1

    Additional mRNA sequence: 

    AB048348.1 AK091101.1 AK308847.1 BC012915.1 

    9 DOTS entries:

    DT.70101296  DT.211745  DT.100747189  DT.100747191  DT.95189009  DT.121416413  DT.121416623  DT.91712281 
    DT.121416439 

    Selected AceView cDNA sequences (see all 124):

    BX092419 AA465440 AA917760 AW948888 N56690 BX953300 BX452455 AI572895 
    BX096214 AI281005 BM843631 H91670 BM710721 AI301592 CB306822 AA866176 
    AI653794 AW006192 AA975746 BF727432 BG189314 BU166936 AA465365 AB048348 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OMA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATATTGAT
    OMA1 Expression
    About this image


    OMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Cerebral Cortex
             Septum   
    OMA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OMA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.425769

    UniProtKB/Swiss-Prot: OMA1_HUMAN, Q96E52
    Tissue specificity: Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OMA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OMA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oma11 , 5 OMA1 homolog, zinc metallopeptidase (S. cerevisiae)1, 5 75.93(n)1
    72.2(a)1
      4 (47.60 cM)5
    670131  NM_025909.31  NP_080185.11 
     1033138125 
    chicken
    (Gallus gallus)
    Aves OMA11 OMA1 zinc metallopeptidase homolog (S. cerevisiae) 65.43(n)
    58.48(a)
      424670  XM_422503.4  XP_422503.3 
    lizard
    (Anolis carolinensis)
    Reptilia OMA16
    OMA1 zinc metallopeptidase
    51(a)
    1 ↔ 1
    4(102030481-102064286)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia oma11 OMA1 zinc metallopeptidase 64.62(n)
    59.89(a)
      101735066  XM_004913950.1  XP_004914007.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003311861 metalloendopeptidase OMA1, mitochondrial-like 58.02(n)
    57.14(a)
      100331186  XM_002665672.3  XP_002665718.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OMA1(YKR087C)4
    OMA11
    Metalloendopeptidase of the mitochondrial inner membrane, more4
    OMA11
    46.16(n)1
    29.37(a)1
      11(604232-603195)4
    8539621, 4  NP_013013.21, 4 


    ENSEMBL Gene Tree for OMA1 (if available)
    TreeFam Gene Tree for OMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OMA1 (see all 1465)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357084
    A colorectal cancer sample4--see VAR_0357082 L V mis40--------
    rs115808931,2
    C,F,H--58946045(+) CCTCTC/TCCCCA 1 -- int1 trp37Minor allele frequency- T:0.06NS NA 898
    rs1822145191,2
    --58946060(+) TGTTTC/GTTGCT 1 -- int10--------
    rs1482985211,2
    --58946072(+) TGTCAA/TCTGAA 1 -- int10--------
    rs1878725531,2
    --58946147(+) CATCCA/GCAGGT 1 -- int10--------
    rs1914863181,2
    --58946156(+) GTGAAA/GACAAG 1 -- int10--------
    rs1833717701,2
    --58946318(+) TATAAA/GAACTA 1 -- int10--------
    rs726699011,2
    C,F--58946339(+) TCATTC/TCTCAT 1 -- int10--------
    rs1887797051,2
    --58946345(+) CTCATC/TCACTA 1 -- int10--------
    rs1155723281,2
    C,F--58946432(+) CCTCAT/CTGAAG 1 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for OMA1 (58881056 - 59012474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OMA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829948CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OMA1
    DNA2.0 Custom Variant and Variant Library Synthesis for OMA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OMA1           About GenesLikeMe

    Genetic Association Database (GAD): OMA1
    Human Genome Epidemiology (HuGE) Navigator: OMA1 (1 document)

    Export disorders for OMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OMA1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with OMA1)
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    1. Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif. (PubMed id 12886954)1, 2, 9 Bao Y.-C....Kumagai H. (DNA Res. 2003)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. (PubMed id 20038677)1, 2 Head B.... van der Bliek A.M. (J. Cell Biol. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. (PubMed id 21220648)2 Daoud H....Rouleau G.A. (Arch. Neurol. 2011)
    7. OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. (PubMed id 17615298)1 Duvezin-Caubet S....Reichert A.S. (Mol. Biol. Cell 2007)
    8. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115209 HGNC: 29661 AceView: MPRP-1 Ensembl:ENSG00000162600 euGenes: HUgn115209
    ECgene: OMA1 H-InvDB: OMA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OMA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OMA1 gene:
    Search GeneIP for patents involving OMA1

    GeneCards and IP:
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