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Aliases for OMA1 Gene

Aliases for OMA1 Gene

  • OMA1 Zinc Metallopeptidase 2 3
  • Overlapping With The M-AAA Protease 1 Homolog 3 4
  • Overlapping Activity With M-AAA Protease 2 3
  • Metalloprotease-Related Protein 1 3 4
  • Zinc Metallopeptidase OMA1 2 3
  • MPRP-1 3 4
  • OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) 2
  • Metalloendopeptidase OMA1, Mitochondrial 3
  • OMA1 Homolog, Zinc Metallopeptidase 3
  • OMA1 Zinc Metallopeptidase Homolog 3
  • Metalloprotease Related Protein 1 3
  • 2010001O09Rik 3
  • EC 3.4.24.- 4
  • Peptidase 3
  • YKR087C 3
  • ZMPOMA1 3
  • MPRP1 4
  • DAB1 3

External Ids for OMA1 Gene

Summaries for OMA1 Gene

GeneCards Summary for OMA1 Gene

OMA1 (OMA1 Zinc Metallopeptidase) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Guidance Cues and Growth Cone Motility. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for OMA1 Gene

  • Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMA1 Gene

Genomics for OMA1 Gene

Genomic Location for OMA1 Gene

Start:
58,415,384 bp from pter
End:
58,546,802 bp from pter
Size:
131,419 bases
Orientation:
Minus strand

Genomic View for OMA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMA1 Gene

Regulatory Elements for OMA1 Gene

Proteins for OMA1 Gene

  • Protein details for OMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E52-OMA1_HUMAN
    Recommended name:
    Metalloendopeptidase OMA1, mitochondrial
    Protein Accession:
    Q96E52
    Secondary Accessions:
    • D3DQ54
    • Q5T3G6
    • Q5T3G7
    • Q5T3G8
    • Q5T3G9
    • Q5T3H0
    • Q8NBB3

    Protein attributes for OMA1 Gene

    Size:
    524 amino acids
    Molecular mass:
    60120 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13522.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13523.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13524.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13525.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22238.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OMA1 Gene

Proteomics data for OMA1 Gene at MOPED

Post-translational modifications for OMA1 Gene

  • In normal conditions, cleaved into an inactive 40 kDa form. Following CCCP treatment that induces loss of mitochondrial membrane potential, the 40 kDa form is reduced in favor of an active 60 kDa form.

Other Protein References for OMA1 Gene

No data available for DME Specific Peptides for OMA1 Gene

Domains for OMA1 Gene

Protein Domains for OMA1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

OMA1_HUMAN
Family:
  • Belongs to the peptidase M48 family.:
    • Q96E52
genes like me logo Genes that share domains with OMA1: view

No data available for Gene Families for OMA1 Gene

Function for OMA1 Gene

Molecular function for OMA1 Gene

UniProtKB/Swiss-Prot Function: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.

Enzyme Numbers (IUBMB) for OMA1 Gene

Gene Ontology (GO) - Molecular Function for OMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IMP 20038677
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OMA1: view
genes like me logo Genes that share phenotypes with OMA1: view

Animal Models for OMA1 Gene

MGI Knock Outs for OMA1:

miRNA for OMA1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for OMA1 Gene

Localization for OMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMA1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OMA1 Gene COMPARTMENTS Subcellular localization image for OMA1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IDA 20038677
genes like me logo Genes that share ontologies with OMA1: view

Pathways for OMA1 Gene

genes like me logo Genes that share pathways with OMA1: view

Pathways by source for OMA1 Gene

Interacting Proteins for OMA1 Gene

Gene Ontology (GO) - Biological Process for OMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002024 diet induced thermogenesis IMP 22433842
GO:0006006 glucose metabolic process IMP 22433842
GO:0006508 proteolysis --
GO:0006515 misfolded or incompletely synthesized protein catabolic process IMP 20038677
GO:0006629 lipid metabolic process IMP 22433842
genes like me logo Genes that share ontologies with OMA1: view

Transcripts for OMA1 Gene

mRNA/cDNA for OMA1 Gene

Unigene Clusters for OMA1 Gene

OMA1 zinc metallopeptidase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OMA1 Gene

No ASD Table

Relevant External Links for OMA1 Gene

GeneLoc Exon Structure for
OMA1
ECgene alternative splicing isoforms for
OMA1

Expression for OMA1 Gene

mRNA expression in normal human tissues for OMA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OMA1 Gene

SOURCE GeneReport for Unigene cluster for OMA1 Gene Hs.425769

mRNA Expression by UniProt/SwissProt for OMA1 Gene

Q96E52-OMA1_HUMAN
Tissue specificity: Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expressions with OMA1: view

Orthologs for OMA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for OMA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OMA1 36
  • 86.23 (n)
  • 80.5 (a)
OMA1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OMA1 36
  • 86.39 (n)
  • 81.11 (a)
OMA1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oma1 36
  • 75.93 (n)
  • 72.2 (a)
Oma1 16
Oma1 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OMA1 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oma1 36
  • 77.95 (n)
  • 72.51 (a)
chicken
(Gallus gallus)
Aves OMA1 36
  • 65.43 (n)
  • 58.48 (a)
OMA1 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OMA1 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oma1 36
  • 64.62 (n)
  • 59.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331186 36
  • 58.02 (n)
  • 57.14 (a)
OMA1 37
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OMA1 36
  • 46.16 (n)
  • 29.37 (a)
OMA1 37
  • 25 (a)
OneToOne
OMA1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07711g 36
  • 44.26 (n)
  • 31.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oma1 36
  • 47.4 (n)
  • 37.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToOne
Species with no ortholog for OMA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMA1 Gene

ENSEMBL:
Gene Tree for OMA1 (if available)
TreeFam:
Gene Tree for OMA1 (if available)

Paralogs for OMA1 Gene

No data available for Paralogs for OMA1 Gene

Variants for OMA1 Gene

Sequence variations from dbSNP and Humsavar for OMA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs180148 -- 58,495,185(+) aacac(C/T)gcagg intron-variant
rs184617 -- 58,485,416(+) GGTTT(C/T)TTTAA intron-variant
rs186822 -- 58,493,702(+) atcca(A/C)cttac intron-variant
rs186823 -- 58,494,970(+) cacac(A/G)tatgt intron-variant
rs193133 -- 58,485,297(+) TGTTT(G/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OMA1 Gene

Variant ID Type Subtype PubMed ID
nsv829948 CNV Gain 17160897

Relevant External Links for OMA1 Gene

HapMap Linkage Disequilibrium report
OMA1

Disorders for OMA1 Gene

Relevant External Links for OMA1

Genetic Association Database (GAD)
OMA1
Human Genome Epidemiology (HuGE) Navigator
OMA1
genes like me logo Genes that share disorders with OMA1: view

No data available for UniProtKB/Swiss-Prot for OMA1 Gene

Publications for OMA1 Gene

  1. Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif. (PMID: 12886954) Bao Y.-C. … Kumagai H. (DNA Res. 2003) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. (PMID: 20038677) Head B. … van der Bliek A.M. (J. Cell Biol. 2009) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for OMA1 Gene

Sources for OMA1 Gene

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