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OLR1 Gene

protein-coding   GIFtS: 62
GCID: GC12M010310

Oxidized Low Density Lipoprotein (Lectin-Like) Receptor...

(Previous name: oxidised low density lipoprotein (lectin-like) receptor...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 11 2     SLOX12
LOX12 3 5     Ox LDL Receptor 12
Lectin-Type Oxidized LDL Receptor 12 3     Oxidized Low-Density Lipoprotein Receptor 12
CLEC8A2 3     Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form2
C-Type Lectin Domain Family 8 Member A2 3     Scavenger Receptor Class E, Member 12
hLOX-12 3     LOX-13
Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 11     Lectin-Like Oxidized LDL Receptor 13
LOXIN2     Lectin-Like OxLDL Receptor 13
SCARE12     Ox-LDL Receptor 13

External Ids:    HGNC: 81331   Entrez Gene: 49732   Ensembl: ENSG000001733917   OMIM: 6026015   UniProtKB: P783803   

Export aliases for OLR1 gene to outside databases

Previous GC identifers: GC12M009993 GC12M010433 GC12M010211 GC12M010202 GC12M010054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OLR1 Gene:
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is
regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized
low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein
may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk
of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Feb 2010)

GeneCards Summary for OLR1 Gene:
OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1) is a protein-coding gene. Diseases associated with OLR1 include myocardial infarction, and coronary stenosis. GO annotations related to this gene include low-density lipoprotein receptor activity and carbohydrate binding. An important paralog of this gene is CLEC9A.

UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low
density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces
vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative
conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased
production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a
reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as
a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,
thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by
acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as
a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both
Gram-negative and Gram-positive bacteria

Gene Wiki entry for OLR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OLR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   MyoD   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLR1 promoter sequence
   Search Chromatin IP Primers for OLR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.1-p12.3

OLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010310:  view genomic region     (about GC identifiers)

Start:
10,310,899 bp from pter      End:
10,324,790 bp from pter
Size:
13,892 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380 (See protein sequence)
Recommended Name: Oxidized low-density lipoprotein receptor 1  
Size: 273 amino acids; 30959 Da
Subunit: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70
6 PDB 3D structures from and Proteopedia for OLR1:
1YPO (3D)        1YPQ (3D)        1YPU (3D)        1YXJ (3D)        1YXK (3D)        3VLG (3D)    
Secondary accessions: A8K7V9 B4DI48 G3V1I4 Q2PP00 Q7Z484
Alternative splicing: 3 isoforms:  P78380-1   P78380-2   P78380-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OLR1: NX_P78380

Explore proteomics data for OLR1 at MOPED

Post-translational modifications: 

  • The intrachain disulfide-bonds prevent N-glycosylation at some sites1
  • N-glycosylated1
  • Glycosylation2 at Asn73, Asn139

  • See OLR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166103.1  NP_001166104.1  NP_002534.1  

    ENSEMBL proteins: 
     ENSP00000309124   ENSP00000444457   ENSP00000445085   ENSP00000439251   ENSP00000405116  
     ENSP00000442389   ENSP00000438925   ENSP00000340572   ENSP00000438744   ENSP00000444068  
    Reactome Protein details: P78380

    OLR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for OLR1 (LOX-1/OLR1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for OLR1
    OriGene Protein Over-expression Lysate for OLR1
    OriGene MassSpec for OLR1
    OriGene Custom Protein Services for OLR1
    GenScript Custom Purified and Recombinant Proteins Services for OLR1
    Sino Biological Recombinant Protein for OLR1
    Sino Biological Cell Lysate for OLR1
    ProSpec Recombinant Protein for OLR1
    Browse Proteins at Cloud-Clone Corp.

    OLR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for OLR1 (LOX-1/OLR1)
    OriGene Antibodies for OLR1
    OriGene Custom Antibody Services for OLR1
    Novus Biologicals OLR1 Antibodies
    Abcam antibodies for OLR1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for OLR1
    Search LSBio for Antibodies for OLR1

    OLR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OLR1
    R&D Systems ELISAs for OLR1 (LOX-1/OLR1)         (see all)
    GenScript Custom Assay Services for OLR1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P78380

    ProtoNet protein and cluster: P78380

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
    Domain: The C-type lectin domain mediates the recognition and binding of oxLDL
    Similarity: Contains 1 C-type lectin domain


    OLR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLR1_HUMAN, P78380
    Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low
    density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces
    vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative
    conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased
    production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a
    reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as
    a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,
    thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by
    acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as
    a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both
    Gram-negative and Gram-positive bacteria
    Induction: By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions
    such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL,
    reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of
    oxLDL-induced vascular dysfunction

         Genatlas biochemistry entry for OLR1:
    oxidized low density lipoprotein receptor 1lectin-like,in the NK (natural killer) complex, taken up by vascular
    endothelium,most abundant in placenta,also expressed in lung,bone marrow,central nervous system,aorta,testis and
    kidney,also expressed in macrophages,but not in vascular smooth muscle cells,involved in endothelial dysfunction
    and atherosclerosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005041low-density lipoprotein receptor activity IEA--
    GO:0030246carbohydrate binding IEA--
         
    OLR1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Olr1):
     cardiovascular system  homeostasis/metabolism  immune system  muscle  normal 

    OLR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for OLR1: Olr1tm1Lex Olr1tm1Meht

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OLR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OLR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OLR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OLR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OLR1:
    hsa-mir-98-5p (MIRT027749), hsa-mir-21-5p (MIRT031012), hsa-mir-155-5p (MIRT020773)

    Block miRNA regulation of human, mouse, rat OLR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLR1 (see all 17):
    hsa-miR-607 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidOLR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OLR1
    Predesigned siRNA for gene silencing in human, mouse, rat OLR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OLR1

    Clone
    Products:
         
    OriGene clones in human, mouse for OLR1 (see all 16)
    OriGene ORF clones in mouse, rat for OLR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): OLR1 (NM_016729)
    Sino Biological Human cDNA Clone for OLR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OLR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OLR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OLR1_HUMAN, P78380: Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane
    raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus3
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9052782

    OLR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OLR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2PPAR signaling pathway
    PPAR signaling pathway
    3Phagosome
    Phagosome
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for OLR1
        Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for OLR1):
        PPAR signaling pathway
    Phagosome


    OLR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OLR1: 
              Insulin Resistance in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for OLR1 (P783802, 3 ENSP000003091244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234258P349312, 3, ENSP000003964864MINT-58370 I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349312, 3MINT-58370 I2D: score=1 
    ENSG00000236251P349312, 3MINT-58370 I2D: score=1 
    HSPA1LP349312, 3MINT-58370 I2D: score=1 
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS9052782
    GO:0006954inflammatory response IEA--
    GO:0007159leukocyte cell-cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0008015blood circulation TAS9052782

    OLR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OLR1

    Selected Novoseek inferred chemical compound relationships for OLR1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atorvastatin 49.7 14 16285995 (4), 16244767 (3), 11557241 (2), 11735125 (2) (see all 6)
    carrageenan 45 5 16188066 (2), 19252093 (1), 12857870 (1), 10764682 (1)
    kappa-carrageenan 44.3 3 14656932 (1), 16690797 (1)
    fucoidan 42.7 1 12857870 (1)
    isorhamnetin 42.3 2 16963021 (2)
    nadph 41.5 14 19878672 (3), 20203069 (2), 19269986 (1), 19592619 (1) (see all 10)
    inosine monophosphate 40.7 2 12857870 (1), 10764682 (1)
    lysophosphatidylcholine 40.5 9 10640439 (2), 11795267 (1), 17963022 (1)
    caffeic acid phenethyl ester 39.5 1 16484599 (1)
    lipid 37.8 15 16373606 (3), 20216085 (3), 9494115 (1), 16244767 (1) (see all 10)



    OLR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OLR1 gene (3 alternative transcripts): 
    NM_001172632.1  NM_001172633.1  NM_002543.3  

    Unigene Cluster for OLR1:

    Oxidized low density lipoprotein (lectin-like) receptor 1
    Hs.412484  [show with all ESTs]
    Unigene Representative Sequence: NM_002543
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309539(uc010sgz.1 uc001qxo.1 uc021qvb.1 uc010sha.1)
    ENST00000544577 ENST00000543993 ENST00000545927 ENST00000432556 ENST00000536989
    ENST00000539518 ENST00000538745 ENST00000339968 ENST00000538873 ENST00000543414

    miRNA
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    Block miRNA regulation of human, mouse, rat OLR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLR1 (see all 17):
    hsa-miR-607 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidOLR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OLR1
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    GenScript: all cDNA clones in your preferred vector (see all 4): OLR1 (NM_016729)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLR1
    Primer
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    OriGene qPCR primer pairs and template standards for OLR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OLR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OLR1
      QuantiTect SYBR Green Assays in human, mouse, rat OLR1
      QuantiFast Probe-based Assays in human, mouse, rat OLR1

    Additional mRNA sequence: 

    AB010710.1 AB102861.1 AF035776.1 AK292124.1 AK295409.1 AK298040.1 AK308009.1 AK316353.1 
    BC022295.1 

    11 DOTS entries:

    DT.211487  DT.101971071  DT.92423593  DT.95263074  DT.92423587  DT.100793677  DT.92033139  DT.92423594 
    DT.100701125  DT.100793680  DT.121129410 

    Selected AceView cDNA sequences (see all 179):

    CR602659 AU076397 BP353308 CA309323 BP353370 AU135631 BX344276 AA682386 
    CB128527 AU107156 BP354174 AL551100 BC055085 BE501554 BG231939 AU137679 
    NM_002543 CA308072 AA044087 BG547497 BP353560 BP355329 BP352535 AU135523 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OLR1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:                    -     -     -                             -                                       
    SP2:                    -     -     -                             -     -     -     -                     
    SP3:                    -     -     -                 -     -     -                                       
    SP4:                          -     -     -                       -                                       
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for OLR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACTACAA
    OLR1 Expression
    About this image


    OLR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
    OLR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OLR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412484

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Tissue specificity: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung,
    liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of
    dendritic cells. Widely expressed at intermediate and low level

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OLR1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olr11 , 5 oxidized low density lipoprotein (lectin-like) receptor more1, 5 73.66(n)1
    60.3(a)1
      6 (63.35 cM)5
    1080781  NM_138648.21  NP_619589.21 
     1294852465 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    2(81818136-81823316)


    ENSEMBL Gene Tree for OLR1 (if available)
    TreeFam Gene Tree for OLR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OLR1 gene
    CLEC9A2  CLEC1B2  CLEC7A2  CLEC12B2  CLEC12A2  CLEC1A2  
    14 SIMAP similar genes for OLR1 using alignment to 8 protein entries:     OLR1_HUMAN (see all proteins):
    FCER2    CLEC10A    KLRG1    CLEC1B    CLEC2D    KLRC1
    CLEC7A    KLRD1    KLRC2    CLEC2L    CLEC12B    CLEC4E
    CLEC4C    ASGR1

    OLR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OLR1 (see all 446)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110536461,2,,4
    C,F,Hother110186538(+) TGGCTC/GTTTTC 5 N K mis1 int1 trp321Minor allele frequency- G:0.14NS EA NA WA EU 7617
    rs18018091,2
    C,H--10055074(-) AGACAG/CACACA 3 -- ut314Minor allele frequency- C:0.41NA WA CSA 32
    rs110536451,2
    C,F,H--10183562(+) AGTGGT/AAGCGG 3 -- ds500112Minor allele frequency- A:0.18NS EA NA WA 878
    rs1824357371,2
    --10183629(+) GAGGCA/GGAGGT 3 -- ds50010--------
    rs1853848761,2
    --10183678(+) AGCAAA/CAAGAG 3 -- ds50010--------
    rs79646411,2
    C,F,A,H--10183754(+) aggatA/Ttacca 3 -- ds500117Minor allele frequency- T:0.15NS EA NA WA CSA 1181
    rs359434181,2
    C,F--10183794(-) GGTTCG/ATCTTA 3 -- ds50012Minor allele frequency- A:0.01NS 94
    rs348743751,2
    C,F--10183810(-) TGCCAG/CAATTT 3 -- ds50019Minor allele frequency- C:0.28NS NA WA EA 458
    rs349482111,2
    C,F--10183818(-) CTCATC/TCATGC 3 -- ds50013Minor allele frequency- T:0.01NS NA 214
    rs1903350471,2
    --10183944(+) TATACG/TCCTAA 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for OLR1 (10310899 - 10324790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OLR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898757CNV Gain21882294
    nsv898758CNV Gain21882294

    Human Gene Mutation Database (HGMD): OLR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OLR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OLR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602601   
    OMIM disorders: 608446  
    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
  • Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction
    susceptibility
  • Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to
    some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD,
    while according to other (PubMed:15000751 and PubMed:15060104) they do not

  • Selected diseases for OLR1 (see all 43):    
    About MalaCards
    myocardial infarction    coronary stenosis    low renin hypertension    atherosclerosis
    nonalcoholic steatohepatitis    cerebral amyloid angiopathy    acute myocardial infarction    coronary artery disease
    alzheimer's disease    monocytic leukemia    intrahepatic cholestasis    proteinuria
    cerebrovascular disease    hypercholesterolemia    cholestasis    coronary heart disease
    vascular disease    was-related disorders    osteoarthritis    ischemia

    3 diseases from the University of Copenhagen DISEASES database for OLR1:
    Atherosclerosis     Heart disease     Hypertension

    OLR1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for OLR1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 76.6 88 20146162 (3), 12163130 (3), 17614937 (3), 20508287 (2) (see all 59)
    atherosclerotic plaque 69.3 28 16473764 (2), 18092947 (2), 10377073 (1), 20146162 (1) (see all 21)
    cardiovascular diseases 46 12 17612285 (2), 20181930 (1), 17376315 (1), 20073134 (1) (see all 10)
    hyperlipidemia 38.1 2 18282574 (1), 16829343 (1)
    coronary artery disease 35.8 14 12810610 (3), 16829343 (3), 16251892 (2), 16724009 (1) (see all 6)
    monocytic leukemia 32.6 2 11728449 (1), 15016631 (1)
    preeclampsia 32.5 25 19104003 (5), 19035131 (4), 19080712 (4), 19570417 (2) (see all 8)
    vascular diseases 31.4 7 12163130 (2), 19601801 (1), 18092947 (1), 11413048 (1) (see all 6)
    coronary heart disease 24.6 6 16541167 (2), 20146162 (1), 15206153 (1), 16829343 (1)
    myocardial infarction 24.1 13 18221114 (2), 15562935 (1), 15976314 (1), 18092947 (1) (see all 11)

    Genetic Association Database (GAD): OLR1
    Human Genome Epidemiology (HuGE) Navigator: OLR1 (38 documents)

    Export disorders for OLR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OLR1 gene, integrated from 10 sources (see all 365):
    (articles sorted by number of sources associating them with OLR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. (PubMed id 12810610)1, 2, 4, 9 Chen Q.... Kamboh M.I. (Circulation 2003)
    2. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. (PubMed id 12646194)1, 2, 4, 9 Tatsuguchi M....Matsuoka R. (Biochem. Biophys. Res. Commun. 2003)
    3. Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease. (PubMed id 15860461)1, 2, 4, 9 D'Introno A.... Panza F. (J. Gerontol. 2005)
    4. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. (PubMed id 15060104)1, 2, 4, 9 Bertram L.... Tanzi R.E. (J. Med. Genet. 2004)
    5. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. (PubMed id 12807963)1, 2, 4, 9 Lambert J.-C.... Amouyel P. (J. Med. Genet. 2003)
    6. Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12. (PubMed id 12384789)1, 2, 4, 9 Luedecking-Zimmer E....Kamboh M.I. (Hum. Genet. 2002)
    7. Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene. (PubMed id 9763655)1, 2, 3 Li X.... Wang X. (Cytogenet. Cell Genet. 1998)
    8. Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). (PubMed id 15935375)1, 2, 9 Chen M. and Sawamura T. (J. Mol. Cell. Cardiol. 2005)
    9. The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile. (PubMed id 9828121)1, 2, 9 Yamanaka S.... Iwao H. (Genomics 1998)
    10. Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels. (PubMed id 18469066)1, 4, 9 Brinkley T.E....Hagberg J.M. (Exp. Physiol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4973 HGNC: 8133 AceView: OLR1 Ensembl:ENSG00000173391 euGenes: HUgn4973
    ECgene: OLR1 Kegg: 4973 H-InvDB: OLR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OLR1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_249

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OLR1 gene:
    Search GeneIP for patents involving OLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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