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OLR1 Gene

protein-coding   GIFtS: 63

GC12M010202
oxidized low density lipoprotein (lectin-like) receptor 1
(Previous name: oxidised low density lipoprotein (lectin-like) receptor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for OLR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CLEC8A 1, 2
LOX-1 1, 3
LOX1 2, 3, 5
SCARE1 1, 2
hLOX-1 3
Descriptions
Lectin-like oxLDL receptor 1 3
Lectin-like oxidized LDL receptor 1 3
Lectin-type oxidized LDL receptor 1 2, 3
Ox-LDL receptor 1 3
oxidised low density lipoprotein (lectin-like) receptor 1 1, 2
oxidized low density lipoprotein (lectin-like) receptor 1 2
scavenger receptor class E, member 1 2
External Ids
HGNC: 81331
Entrez Gene: 49732
UniProtKB: P783803
Ensembl: ENSG000001733917
Search outside databases for aliases for OLR1 gene

Previous GC identifers: GC12M009993 GC12M010433 GC12M010211

Summaries
for OLR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for OLR1:
This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is
regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and
degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of
Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this
gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the
risk of Alzheimer's disease. Alternative transcript variants have been described but their
full-length sequence has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively
modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of
atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in
pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL
induces the activation of NF-kappa-B through an increased production of intracellular reactive
oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide
(NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor
for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,
thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory
process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced
inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated
platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria

Gene Wiki entry for OLR1

Genomic Location
for OLR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OLR1 gene  

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.1-p12.3

OLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010202:     (about GC identifiers)

Start:
 10,202,166 bp from pter
End:
 10,216,057 bp from pter
Size:
 13,892 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009714.16  

Proteins
for OLR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380 (See protein sequence)
Recommended Name: Oxidized low-density lipoprotein receptor 1  
Size: 273 amino acids; 30959 Da
Subunit: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with
HSP70
Subcellular location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=A
secreted form also exists
PDB structures from and Proteopedia :
1YPO (3D)    1YPQ (3D)    1YPU (3D)    1YXJ (3D)    1YXK (3D)    
Secondary accessions: Q2PP00 Q7Z484

Post-translational modifications:

  • The intrachain disulfide-bonds prevent N-glycosylation at some sites1
  • N-glycosylated1


    • REFSEQ proteins: NP_002534.1  

    ENSEMBL proteins: 
    ENSP00000309124 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for OLR1 (LOX-1/SR-E1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LOX 1)
    Human Recombinant Proteins from Abnova (OLR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005624 membrane fraction TAS9052782
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS9052782
    About this table

    Antibodies for OLR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for OLR1
    R&D Systems Antibodies for OLR1 (LOX-1/SR-E1)
    Antibodies from Abcam (LOX 1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (OLR1)
    Novus Biologicals Antibodies for OLR1

    Assays for OLR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for OLR1 (LOX-1/SR-E1)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for OLR1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin
     IPR002353 AntifreezeII


       GeneDecks  OLR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P78380

    ProtoNet protein and cluster: P78380

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
    Domain: The C-type lectin domain mediates the recognition and binding of oxLDL
    Similarity: Contains 1 C-type lectin domain

    Gene Function
    for OLR1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (OLR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OLR1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002543

                  Applied Biosystems Silencer® siRNAs for OLR1

                  Sigma-Aldrich siRNA and siRNA Panels for OLR1  
                         Sigma-Aldrich shRNA Panels and shRNA for OLR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for OLR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002543
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002543
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002543 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002543

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Function: Receptor that mediates the recognition, internalization and degradation of oxidatively
    modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of
    atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in
    pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL
    induces the activation of NF-kappa-B through an increased production of intracellular reactive
    oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide
    (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor
    for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,
    thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory
    process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced
    inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated
    platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria
    Induction: By inflammatory cytokines such as TNF-alpha, IFN-gamma, IL-6 and by pathological
    conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in
    atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that
    it may participate in amplification of oxLDL-induced vascular dysfunction

    Genatlas biochemistry entry for OLR1:
    oxidized low density lipoprotein receptor 1lectin-like,in the NK (natural killer) complex, taken up
    by vascular endothelium,most abundant in placenta,also expressed in lung,bone marrow,central
    nervous system,aorta,testis and kidney,also expressed in macrophages,but not in vascular smooth
    muscle cells,involved in endothelial dysfunction and atherosclerosis

    5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Olr1):

    homeostasis/metabolismimmune systemmusclenormal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005041 low-density lipoprotein receptor activity IEA--
    GO:0005515 protein binding IEA--
    GO:0005529 sugar binding IEA--
    About this table

    Pathways & Interactions
    for OLR1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for OLR1):
     hsa03320 PPAR signaling pathway

       GeneDecks  OLR1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  OLR1 


    5/31 Interacting proteins for OLR1 (P783802 ENSP000003091243) via UniProtKB, MINT, and/or STRING (see all 31 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1LP349312, ENSP000003648053MINT-58370 STRING (score=.805)
    CD40ENSP000002790613STRING (score=.953)
    APOBENSP000002332423STRING (score=.948)
    TLR2ENSP000002600103STRING (score=.941)
    CCL2ENSP000002258313STRING (score=.935)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis TAS9052782
    GO:0006954 inflammatory response IEA--
    GO:0006955 immune response IEA--
    GO:0007155 cell adhesion IEA--
    GO:0008015 blood circulation TAS9052782
    About this table

    Drugs & Compounds
    for OLR1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OLR1
    10/21 Novoseek chemical compound relationships for OLR1 gene (see all 21 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    carrageenan 48.03 5 16188066 (2), 19252093 (1), 12857870 (1), 10764682 (1)
    kappa-carrageenan 47.15 3 14656932 (1), 16690797 (1)
    isorhamnetin 46.40 2 16963021 (2)
    inosine monophosphate 43.43 2 12857870 (1), 10764682 (1)
    lysophosphatidylcholine 43.36 9 10640439 (2), 11795267 (1), 17963022 (1)
    caffeic acid phenethyl ester 43.03 1 16484599 (1)
    adma 40.21 9 15010359 (4), 17923264 (3)
    superoxide 35.62 10 12958047 (2), 14967724 (2), 18300860 (1), 16344366 (1) (see all 7)
    nadph 29.85 5 16344366 (1), 17433786 (1), 19104003 (1), 15855339 (1) (see all 5)
    nitric oxide 29.50 18 15010359 (2), 12575983 (2), 15016631 (2), 17538005 (1) (see all 11)
    About this table


    Transcripts
    for OLR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (OLR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (OLR1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002543

                  Sigma-Aldrich siRNA and siRNA Panels for OLR1  
                         Sigma-Aldrich shRNA Panels and shRNA for OLR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002543  

    REFSEQ mRNAs for OLR1 gene: 

    NM_002543.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002543  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002543
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002543
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002543 

    Additional cDNA sequence: 

    AB010710.1 AB102861.1 AF035776.1 AK292124.1 AK295409.1 AK298040.1 AK308009.1 AK316353.1 
    BC022295.1 BC055085.1 CR602659.1 

    12 DOTS entries:

    DT.211487  DT.101971071  DT.92423593  DT.95263074  DT.92423587  DT.100793677  DT.92033139  DT.92423594 
    DT.100701125  DT.100793680  DT.121129410  DT.91743106 

    24/179 AceView cDNA sequences (see all 179 ):

    CA309323 CB128527 NM_002543 CA308072 BE501554 BX344276 BG231939 AL551100 
    AU107156 AU135631 AU137679 AA682386 BP354174 CR602659 BP353308 BP353370 
    AA044087 AU076397 BC055085 BP351927 BP352806 BP356190 BP354304 AU138854 

    highest scoring ESTs for OLR1:

    AA114093 AB010710 AF035776 AU076397 AU100073 AU138854 BC022295 BG547497 CB128527 AA044216 

    Unigene Cluster for OLR1:

    Oxidized low density lipoprotein (lectin-like) receptor 1
    Hs.412484  [show with all ESTs]
    Unigene Representative Sequence: NM_002543


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for OLR1 (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:                    -     -     -                             -                                       
    SP2:                    -     -     -                             -     -     -     -                     
    SP3:                    -     -     -                 -     -     -                                       
    SP4:                          -     -     -                       -                                       
    SP5:                                                              -                                       

    About this scheme

    ECgene alternative splicing isoforms for OLR1

    1 Ensembl transcript including schematic representation:
    ENST00000309539  

    Expression
    for OLR1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OLR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OLR1

    1 / 2 / 3

    3 probe-sets matching OLR1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37233_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF079167 0.20 1.00 0.72 1

    		210004_at2, 3 U133-A 1 1.00 1.00 -- -- AF035776 0.80 1.00 0.91 1

    		210004_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  OLR1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CATACTACAA

    SOURCE GeneReport for Unigene cluster: Hs.412484

    Expression variation in blood from EXPOLDB for OLR1

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Tissue specificity: Expressed at high level in endothelial cells and vascular-rich organs such as
    placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra.
    Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level

    Orthologs
    for OLR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for OLR1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 OLR11   -- oxidized low density lipoprotein (lectin-like) receptor more 83.33(n)
    74.07(a)    		 486694  XM_543821.2  XP_543821.2 
    chimpanzee
    (Pan troglodytes)    		 OLR11   -- oxidized low density lipoprotein (lectin-like) receptor more 99.51(n)
    99.27(a)    		 473362  XM_001145768.1  XP_001145768.1 
    cow
    (Bos taurus)    		 OLR11   -- oxidized low density lipoprotein (lectin-like) receptor more 81.16(n)
    72.86(a)    		 281368  NM_174132.2  NP_776557.1 
    rat
    (Rattus norvegicus)    		 Olr11   -- oxidized low density lipoprotein (lectin-like) receptor more 76.12(n)
    65.67(a)    		 140914  NM_133306.1  NP_579840.1 
    mouse
    (Mus musculus)    		 Olr11, 5 65
    		 oxidized low density lipoprotein (lectin-like) receptor more1, 5 73.91(n)1
    60.67(a)1    		 1080781  NM_138648.21  NP_619589.21 
     AF3037445  AI4480435  (see all 9)
    About this table        Species with no ortholog for OLR1

    ENSEMBL Gene Tree for OLR1

    Paralogs
    for OLR1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for OLR1 gene
    CLEC9A2  CLEC1B2  CLEC12B2  CLEC1A2  

    SNPs/Variants
    for OLR1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/203 NCBI SNPs in OLR1 are shown (see all 203 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 118)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs10502861,2
    		A,C,F,H,O10202830(-) AAACTA/GAGCCA 1 -- ut31 ese39Minor allele frequency- G:0.23EA MN EU WA NS NA 2220
    rs79646411,2
    		A,C,F,H10201930(+) aggatA/Ttacca 1 -- ng5110Minor allele frequency- T:0.13EU EA WA NS 934
    rs10502831,2
    		A,C,F,H10203556(-) AGCTAC/TCTGTA 1 -- ut3112Minor allele frequency- T:0.34MN EA NA EU WA NS 950
    rs27421121,2
    		A,C,F,O10216395(-) GATTCG/ATAAAA 1 -- ng31 tfbs39Minor allele frequency- A:0.43EA NA MN 974
    rs27421101,2
    		A,C,F,H10217776(-) agtacG/Acctaa 1 -- ng316Minor allele frequency- A:0.50EU EA WA NS 490
    rs10502891,2
    		C,F,H10202433(-) CAATCG/AGCTTT 1 -- ut31 ese313Minor allele frequency- A:0.03NA EU EA WA NS 1072
    --
    rs110536451,2
    		C,F,H10201738(+) AGTGGT/AAGCGG 1 -- ng516Minor allele frequency- A:0.19EU EA WA NS 514
    rs110536461,2
    		C,F,H10204715(+) TGGCTC/GTTTTC 1 K/N mis1 trp312Minor allele frequency- G:0.18EU EA WA NA NS 1036
    --
    rs123161501,2
    		C,F,H10203558(+) CAGGTA/TGCTAG 1 -- ut315Minor allele frequency- T:0.02EA WA NS 388
    rs105057551,2
    		C,F,H10203229(+) ACAGTT/GTAAAA 1 -- ut3118Minor allele frequency- G:0.30NS NA EU EA WA 1170
    About this table

    HapMap Linkage Disequilibrium images for OLR1 (up to first 250kb)

    Disorders & Mutations
    for OLR1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 602601

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380

  • Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]
  • Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD)
    [MIM:104300]. Involvement in AD is however unclear: according to some authors (PubMed:12354387,
    PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to
    other (PubMed:15000751 and PubMed:15060104) they do not

    • 10/27 Novoseek disease relationships for OLR1 gene (see all 27 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 74.23 71 12163130 (3), 17614937 (3), 16173915 (2), 15001526 (2) (see all 45)
    atherosclerotic plaque 68.60 24 16473764 (2), 18092947 (2), 10377073 (1), 11397703 (1) (see all 18)
    hyperlipidemia 41.39 2 18282574 (1), 16829343 (1)
    monocytic leukemia 35.36 2 11728449 (1), 15016631 (1)
    cardiovascular diseases 29.29 9 17612285 (2), 17376315 (1), 16473764 (1), 17614937 (1) (see all 7)
    vascular diseases 23.95 5 12163130 (2), 18092947 (1), 11413048 (1), 11507327 (1)
    preeclampsia 23.73 18 19104003 (5), 19035131 (4), 19080712 (3), 15708124 (2) (see all 5)
    coronary artery disease 22.19 14 12810610 (3), 16829343 (3), 16251892 (2), 16724009 (1) (see all 6)
    necrosis 22.18 7 14608078 (2), 17939209 (1), 18067591 (1), 18092947 (1) (see all 6)
    coronary atherosclerosis 18.92 2 16829343 (1), 19330905 (1)
    About this table

    Human Gene Mutation Database: OLR1
    Genetic Association Database: OLR1
    Human Genome Epidemiology Navigator: OLR1 (21 documents)

    Medical News
    for OLR1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for OLR1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/241 PubMed articles for OLR1 gene (see all 241 ):

    Search for OLR1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OLR1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4973 HGNC: 8133 AceView: OLR1 Ensembl:ENSG00000173391 euGenes: HUgn4973
    ECgene: OLR1 H-InvDB: OLR1

    Other Databases showing OLR1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing OLR1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_249

    Licensable Technologies
    for OLR1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for OLR1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OLR1:
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for OLR1

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