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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLR1 Gene

protein-coding   GIFtS: 63
GCID: GC12M010310

oxidized low density lipoprotein (lectin-like) receptor...

(Previous name: oxidised low density lipoprotein (lectin-like) receptor...)
 Explore 39 diseases affiliated with
OLR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OLR1    

Aliases
for OLR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 11 2     LOXIN2
CLEC8A1 2 3     SLOX12
LOX12 3 5     Ox LDL Receptor 12
SCARE11 2     Oxidized Low-Density Lipoprotein Receptor 12
LOX-11 3     Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form2
Lectin-Type Oxidized LDL Receptor 12 3     Scavenger Receptor Class E, Member 12
C-Type Lectin Domain Family 8 Member A2 3     Lectin-Like Oxidized LDL Receptor 13
HLOX-11     Lectin-Like OxLDL Receptor 13
Oxidised Low Density Lipoprotein (Lectin-Like) Receptor 11     Ox-LDL Receptor 13

External Ids:    HGNC: 81331   Entrez Gene: 49732   Ensembl: ENSG000001733917   OMIM: 6026015   UniProtKB: P783803   

Export aliases for OLR1 gene to outside databases

Previous GC identifers: GC12M009993 GC12M010433 GC12M010211 GC12M010202 GC12M010054


Summaries
for OLR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OLR1:
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is
regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized
low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may
play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of
myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density
lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular
endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and
apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of
intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric
oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70
protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in
cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion
molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation
end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria

Gene Wiki entry for OLR1


Genomic Views
for OLR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   MyoD   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OLR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OLR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2-p12.3   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.1-p12.3

OLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010310:  view genomic region     (about GC identifiers)

Start:
 10,310,899 bp from pter      End:
 10,324,790 bp from pter
Size:
 13,892 bases      Orientation:
 minus strand

Proteins
for OLR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380 (See protein sequence)
Recommended Name: Oxidized low-density lipoprotein receptor 1  
Size: 273 amino acids; 30959 Da
Subunit: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70
Subcellular location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists
6 PDB 3D structures from and Proteopedia for OLR1:
1YPO (3D)        1YPQ (3D)        1YPU (3D)        1YXJ (3D)        1YXK (3D)        3VLG (3D)    
Secondary accessions: A8K7V9 B4DI48 G3V1I4 Q2PP00 Q7Z484
Alternative splicing: 3 isoforms:  P78380-1   P78380-2   P78380-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OLR1: NX_P78380

Post-translational modifications:

  • The intrachain disulfide-bonds prevent N-glycosylation at some sites1
  • N-glycosylated1
  • View neXtProt modification sites for NX_P78380

    • OLR1 Protein expression data from MOPED and PaxDb:    About this image 
    OLR1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001166103.1  NP_001166104.1  NP_002534.1  

    ENSEMBL proteins: 
     ENSP00000309124   ENSP00000444457   ENSP00000445085   ENSP00000439251   ENSP00000405116  
     ENSP00000442389   ENSP00000438925   ENSP00000340572   ENSP00000438744   ENSP00000444068  
    Reactome Protein details: P78380
    Human Recombinant Protein Products for OLR1: 
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    R&D Systems Recombinant & Natural Proteins for OLR1 (LOX-1/OLR1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: OLR1
    OriGene Protein Over-expression Lysate (see all 2): OLR1
    OriGene Custom Protein Services for OLR1 
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    Novus Biologicals OLR1 Proteins
    Novus Biologicals OLR1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for OLR1
    Uscn Proteins for OLR1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9052782
    GO:0016020membrane TAS9052782

    OLR1 for ontologies           About GeneDecksing



    OLR1 Antibody Products: 
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    ThermoFisher Antibodies for OLR1

    Assay Products for OLR1: 
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    Uscn ELISAs and CLIAs for OLR1

    Protein Domains /
    Families
    for OLR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OLR1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P78380

    ProtoNet protein and cluster: P78380

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
    Domain: The C-type lectin domain mediates the recognition and binding of oxLDL
    Similarity: Contains 1 C-type lectin domain


    Function
    for OLR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLR1_HUMAN, P78380
    Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density
    lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular
    endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and
    apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of
    intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric
    oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70
    protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in
    cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion
    molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation
    end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria
    Induction: By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions such
    as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive
    oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular
    dysfunction

         Genatlas biochemistry entry for OLR1:
    oxidized low density lipoprotein receptor 1lectin-like,in the NK (natural killer) complex, taken up by vascular
    endothelium,most abundant in placenta,also expressed in lung,bone marrow,central nervous system,aorta,testis and
    kidney,also expressed in macrophages,but not in vascular smooth muscle cells,involved in endothelial dysfunction and
    atherosclerosis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005041low-density lipoprotein receptor activity IEA--
    GO:0030246carbohydrate binding IEA--
         
    OLR1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Olr1):
     cardiovascular system  homeostasis/metabolism  immune system  muscle  normal 

    OLR1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for OLR1: Olr1tm1Lex Olr1tm1Meht
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OLR1 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLR1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate OLR1 (see all 17):
    hsa-miR-607 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmid: OLR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLR1 (see all 7)
    OriGene shRNA RFP: OLR1
    OriGene siRNA: OLR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against OLR1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OLR1
    Sirion Biotech Customized adenovirus for overexpression of OLR1 
    Sirion Biotech Customized adenovirus for potent knockdown of OLR1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLR1 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): OLR1 (NM_016729)
    Sino Biological Human cDNA Clone for OLR1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLR1 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLR1


    Pathways & Interactions
    for OLR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phagosome
    		Phagosome1.00
    2PPAR signaling pathway
    		PPAR signaling pathway1.00
    3Cell surface interactions at the vascular wall
    		Cell surface interactions at the vascular wall1.00
    4Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for OLR1
        Hemostasis
    Cell surface interactions at the vascular wall


    2         Kegg Pathways  (Kegg details for OLR1):
        PPAR signaling pathway
    Phagosome


    OLR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for OLR1 (P783802, 3 ENSP000003091244) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1LP349312, 3MINT-58370 I2D: score=1 
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    OLR1P783802MINT-7213199
    APOBENSP000002332424STRING: ENSP00000233242
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS9052782
    GO:0006954inflammatory response IEA--
    GO:0007159leukocyte cell-cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0008015blood circulation TAS9052782

    OLR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OLR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OLR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLR1
    10/36 Novoseek chemical compound relationships for OLR1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atorvastatin 49.7 14 16285995 (4), 16244767 (3), 11557241 (2), 11735125 (2) (see all 6)
    carrageenan 45 5 16188066 (2), 19252093 (1), 12857870 (1), 10764682 (1)
    kappa-carrageenan 44.3 3 14656932 (1), 16690797 (1)
    fucoidan 42.7 1 12857870 (1)
    isorhamnetin 42.3 2 16963021 (2)
    nadph 41.5 14 19878672 (3), 20203069 (2), 19269986 (1), 19592619 (1) (see all 10)
    inosine monophosphate 40.7 2 12857870 (1), 10764682 (1)
    lysophosphatidylcholine 40.5 9 10640439 (2), 11795267 (1), 17963022 (1)
    caffeic acid phenethyl ester 39.5 1 16484599 (1)
    lipid 37.8 15 16373606 (3), 20216085 (3), 9494115 (1), 16244767 (1) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about OLR1 

    Transcripts
    for OLR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OLR1 gene (3 alternative transcripts): 
    NM_001172632.1  NM_001172633.1  NM_002543.3  

    Unigene Cluster for OLR1:

    Oxidized low density lipoprotein (lectin-like) receptor 1
    Hs.412484  [show with all ESTs]
    Unigene Representative Sequence: NM_002543
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309539(uc010sgz.1 uc001qxo.1 uc021qvb.1 uc010sha.1)
    ENST00000544577 ENST00000543993 ENST00000545927 ENST00000432556 ENST00000536989
    ENST00000539518 ENST00000538745 ENST00000339968 ENST00000538873 ENST00000543414


    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate OLR1 (see all 17):
    hsa-miR-607 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmid: OLR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLR1 (see all 7)
    OriGene shRNA RFP: OLR1
    OriGene siRNA: OLR1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB010710.1 AB102861.1 AF035776.1 AK292124.1 AK295409.1 AK298040.1 AK308009.1 AK316353.1 
    BC022295.1 

    11 DOTS entries:

    DT.211487  DT.101971071  DT.92423593  DT.95263074  DT.92423587  DT.100793677  DT.92033139  DT.92423594 
    DT.100701125  DT.100793680  DT.121129410 

    24/179 AceView cDNA sequences (see all 179):

    CA309323 AU107156 AU076397 BC055085 BP353308 BX344276 AA044087 BP354174 
    CA308072 BP353370 AL551100 AA682386 NM_002543 AU137679 AU135631 BE501554 
    CR602659 BG231939 CB128527 AA938683 BF982378 AU135523 BI522607 BI006994 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for OLR1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:                    -     -     -                             -                                       
    SP2:                    -     -     -                             -     -     -     -                     
    SP3:                    -     -     -                 -     -     -                                       
    SP4:                          -     -     -                       -                                       
    SP5:                                                              -                                       


    ECgene alternative splicing isoforms for OLR1

    Expression
    for OLR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATACTACAA
    OLR1 Expression
    About this image

    OLR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumCardiac FibroblastsEpicardium
    OvaryAntral FollicleCumulus CellsOvary
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)

    See OLR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLR1

    SOURCE GeneReport for Unigene cluster: Hs.412484

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
    Tissue specificity: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver
    and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic
    cells. Widely expressed at intermediate and low level

        SABiosciences Expression via Pathway-Focused PCR Arrays including OLR1: 
              Insulin Resistance in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              PPAR Targets in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for OLR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for OLR1 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CLEC9A6
    		 --
    		 31(a)
    		 1 → many
    		 2(81818136-81823316)


    ENSEMBL Gene Tree for OLR1 (if available)
    TreeFam Gene Tree for OLR1 (if available) 

    Paralogs
    for OLR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLR1 gene
    CLEC9A2  KLRC22  ENSG000002558192  CLEC12A2  KLRC32  CLEC1A2  KLRD12  KLRK12  
    KLRC42  CLEC1B2  ENSG000002556412  CLEC7A2  KLRC12  CLEC12B2  
    14 SIMAP similar genes for OLR1 using alignment to 8 protein entries:     OLR1_HUMAN (see all proteins):
    FCER2    CLEC10A    KLRG1    CLEC1B    CLEC2D    KLRC1
    CLEC7A    KLRD1    KLRC2    CLEC2L    CLEC12B    CLEC4E
    CLEC4C    ASGR1

    OLR1 for paralogs           About GeneDecksing



    Genomic Variants
    for OLR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 NCBI SNPs in OLR1 are shown (see all 360)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs110536461,2
    		C,F,Hother10056610(+) TGGCTC/GTTTTC 5 N K mis1 int1 trp321Minor allele frequency- G:0.14NS EA NA WA EU 7617
    rs79646411,2
    		C,F,A,H--10053820(+) aggatA/Ttacca 3 -- ds500117Minor allele frequency- T:0.15NS EA NA WA CSA 1181
    rs359434181,2
    		C--10053860(-) GGTTCG/ATCTTA 3 -- ds50012Minor allele frequency- A:0.01NS 94
    rs349482111,2
    		C--10053884(-) CTCATC/TCATGC 3 -- ds50013Minor allele frequency- T:0.01NS NA 214
    rs353357221,2
    		C,F,H--10054049(-) CTGTAT/CGAACA 3 -- ds50018Minor allele frequency- C:0.03NS NA WA 826
    rs355552061,2
    		C,F--10054279(-) TCATAT/CAGTAT 3 -- ut314Minor allele frequency- C:0.09NS CSA WA 214
    rs10502891,2
    		C,F,H--10054323(-) CAATCG/AGCTTT 3 -- ut31 ese318Minor allele frequency- A:0.05NA NS EA 1722
    rs756882831,2
    		--10054675(+) TATATG/TTCTAA 3 -- ut310--------
    rs360510491,2
    		C,F--10054701(-) ATATCG/ACTGAA 3 -- ut314Minor allele frequency- A:0.02NS WA NA 332
    rs349387891,2
    		C--10054769(-) ATTCCG/AAAACA 3 -- ut312Minor allele frequency- A:0.01NS 94

    HapMap Linkage Disequilibrium report for OLR1 (10310899 - 10324790 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OLR1: --
    Human Gene Mutation Database (HGMD): OLR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OLR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OLR1

    Disorders / Diseases
    for OLR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OLR1 for disorders           About GeneDecksing

    OMIM gene information: 602601    OMIM disorders: --

    UniProtKB/Swiss-Prot: OLR1_HUMAN, P78380
  • Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction
    • susceptibility
  • Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some
    • authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while
    according to other (PubMed:15000751 and PubMed:15060104) they do not

    20/39 diseases for OLR1 (see all 39):    About MalaCards
    myocardial infarction    alzheimer's disease    atherosclerosis    myocardial infarction susceptibility
    cerebral amyloid angiopathy    pre-eclampsia    acute myocardial infarction    nonalcoholic steatohepatitis
    type 2 diabetes mellitus    coronary stenosis    coronary heart disease    diabetes mellitus
    monocytic leukemia    vascular disease    insulin resistance    hyperlipidemia
    hypercholesterolemia    essential hypertension    was-related disorders    eclampsia

    2 diseases from the University of Copenhagen DISEASES database for OLR1:
    Atherosclerosis     Heart disease

    10/29 Novoseek disease relationships for OLR1 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 76.6 88 20146162 (3), 12163130 (3), 17614937 (3), 20508287 (2) (see all 59)
    atherosclerotic plaque 69.3 28 16473764 (2), 18092947 (2), 10377073 (1), 20146162 (1) (see all 21)
    cardiovascular diseases 46 12 17612285 (2), 20181930 (1), 17376315 (1), 20073134 (1) (see all 10)
    hyperlipidemia 38.1 2 18282574 (1), 16829343 (1)
    coronary artery disease 35.8 14 12810610 (3), 16829343 (3), 16251892 (2), 16724009 (1) (see all 6)
    monocytic leukemia 32.6 2 11728449 (1), 15016631 (1)
    preeclampsia 32.5 25 19104003 (5), 19035131 (4), 19080712 (4), 19570417 (2) (see all 8)
    vascular diseases 31.4 7 12163130 (2), 19601801 (1), 18092947 (1), 11413048 (1) (see all 6)
    coronary heart disease 24.6 6 16541167 (2), 20146162 (1), 15206153 (1), 16829343 (1)
    myocardial infarction 24.1 13 18221114 (2), 15562935 (1), 15976314 (1), 18092947 (1) (see all 11)

    Genetic Association Database (GAD): OLR1
    Human Genome Epidemiology (HuGE) Navigator: OLR1 (38 documents)

    Export disorders for OLR1 gene to outside databases

    Publications
    for OLR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLR1 gene, integrated from 9 sources (see all 339):
    (articles sorted by number of sources associating them with OLR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. (PubMed id 12810610)1, 2, 4, 9 Chen Q.... Kamboh M.I. (2003)
    2. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. (PubMed id 12646194)1, 2, 4, 9 Tatsuguchi M....Matsuoka R. (2003)
    3. Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease. (PubMed id 15860461)1, 2, 4, 9 D'Introno A.... Panza F. (2005)
    4. No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. (PubMed id 15060104)1, 2, 4, 9 Bertram L.... Tanzi R.E. (2004)
    5. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. (PubMed id 12807963)1, 2, 4, 9 Lambert J.-C.... Amouyel P. (2003)
    6. Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12. (PubMed id 12384789)1, 2, 4, 9 Luedecking-Zimmer E....Kamboh M.I. (2002)
    7. Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene. (PubMed id 9763655)1, 2, 3 Li X.... Wang X. (1998)
    8. Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). (PubMed id 15935375)1, 2, 9 Chen M. and Sawamura T. (2005)
    9. The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile. (PubMed id 9828121)1, 2, 9 Yamanaka S.... Iwao H. (1998)
    10. In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction. (PubMed id 15976314)1, 2, 9 Mango R.... Novelli G. (2005)

    External Searches for OLR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OLR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4973 HGNC: 8133 AceView: OLR1 Ensembl:ENSG00000173391 euGenes: HUgn4973
    ECgene: OLR1 Kegg: 4973 H-InvDB: OLR1

    Other Databases showing OLR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OLR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLR1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_249

    Intellectual Property
    for OLR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OLR1 gene:
    Search GeneIP for patents involving OLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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