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Aliases for OLIG3 Gene

Aliases for OLIG3 Gene

  • Oligodendrocyte Transcription Factor 3 2 3
  • Class E Basic Helix-Loop-Helix Protein 20 3 4
  • Class B Basic Helix-Loop-Helix Protein 7 3 4
  • BHLHe20 3 4
  • Bhlhb7 3 4
  • Oligo3 3 4

External Ids for OLIG3 Gene

Previous GeneCards Identifiers for OLIG3 Gene

  • GC06M137660
  • GC06M137793
  • GC06M137855
  • GC06M135375

Summaries for OLIG3 Gene

GeneCards Summary for OLIG3 Gene

OLIG3 (Oligodendrocyte Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include protein dimerization activity and RNA polymerase II transcription corepressor activity. An important paralog of this gene is BHLHE23.

UniProtKB/Swiss-Prot for OLIG3 Gene

  • May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG3 Gene

Genomics for OLIG3 Gene

Regulatory Elements for OLIG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OLIG3 Gene

Chromosome:
6
Start:
137,492,199 bp from pter
End:
137,494,394 bp from pter
Size:
2,196 bases
Orientation:
Minus strand

Genomic View for OLIG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG3 Gene

Proteins for OLIG3 Gene

  • Protein details for OLIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU3-OLIG3_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 3
    Protein Accession:
    Q7RTU3
    Secondary Accessions:
    • Q8N8Q0

    Protein attributes for OLIG3 Gene

    Size:
    272 amino acids
    Molecular mass:
    29358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG3 Gene

Proteomics data for OLIG3 Gene at MOPED

Post-translational modifications for OLIG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OLIG3 Gene

Domains & Families for OLIG3 Gene

Gene Families for OLIG3 Gene

Protein Domains for OLIG3 Gene

Suggested Antigen Peptide Sequences for OLIG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTU3

UniProtKB/Swiss-Prot:

OLIG3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with OLIG3: view

Function for OLIG3 Gene

Molecular function for OLIG3 Gene

UniProtKB/Swiss-Prot Function:
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons

Gene Ontology (GO) - Molecular Function for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG3: view
genes like me logo Genes that share phenotypes with OLIG3: view

Animal Models for OLIG3 Gene

MGI Knock Outs for OLIG3:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLIG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OLIG3 Gene

Localization for OLIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLIG3 Gene COMPARTMENTS Subcellular localization image for OLIG3 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG3: view

Pathways & Interactions for OLIG3 Gene

SuperPathways for OLIG3 Gene

genes like me logo Genes that share pathways with OLIG3: view

Pathways by source for OLIG3 Gene

1 BioSystems pathway for OLIG3 Gene

Gene Ontology (GO) - Biological Process for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression --
GO:0021520 spinal cord motor neuron cell fate specification IEA --
GO:0021522 spinal cord motor neuron differentiation --
genes like me logo Genes that share ontologies with OLIG3: view

No data available for SIGNOR curated interactions for OLIG3 Gene

Drugs & Compounds for OLIG3 Gene

No Compound Related Data Available

Transcripts for OLIG3 Gene

mRNA/cDNA for OLIG3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLIG3 Gene

Oligodendrocyte transcription factor 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLIG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG3 Gene

No ASD Table

Relevant External Links for OLIG3 Gene

GeneLoc Exon Structure for
OLIG3
ECgene alternative splicing isoforms for
OLIG3

Expression for OLIG3 Gene

mRNA expression in normal human tissues for OLIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLIG3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLIG3 Gene



SOURCE GeneReport for Unigene cluster for OLIG3 Gene Hs.195398

genes like me logo Genes that share expression patterns with OLIG3: view

Protein tissue co-expression partners for OLIG3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OLIG3 Gene

Orthologs for OLIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLIG3 35
  • 94.24 (n)
  • 98.9 (a)
OLIG3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG3 35
  • 93.38 (n)
  • 98.53 (a)
OLIG3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olig3 35
  • 91.18 (n)
  • 98.53 (a)
Olig3 16
Olig3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLIG3 35
  • 99.26 (n)
  • 99.26 (a)
OLIG3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig3 35
  • 91.79 (n)
  • 98.9 (a)
oppossum
(Monodelphis domestica)
Mammalia OLIG3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG3 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857919 35
  • 83.64 (n)
  • 87.08 (a)
OLIG3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olig3 35
  • 71.1 (n)
  • 81.37 (a)
Str.11145 35
zebrafish
(Danio rerio)
Actinopterygii olig3 35
  • 72.84 (n)
  • 74.07 (a)
olig4 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-16 36
  • 29 (a)
OneToMany
Species with no ortholog for OLIG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG3 Gene

ENSEMBL:
Gene Tree for OLIG3 (if available)
TreeFam:
Gene Tree for OLIG3 (if available)

Paralogs for OLIG3 Gene

Paralogs for OLIG3 Gene

(2) SIMAP similar genes for OLIG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OLIG3: view

Variants for OLIG3 Gene

Sequence variations from dbSNP and Humsavar for OLIG3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs755163560 -- 137,494,174(+) ATTTT(A/G)TTACA utr-variant-5-prime
rs755277343 -- 137,493,710(+) GGTGG(C/G)CCCCA missense, reference
rs758448229 -- 137,494,971(+) TTTTT(G/T)TCATT upstream-variant-2KB
rs767785444 -- 137,493,398(+) TGTTG(G/T)CTGTG missense, reference
rs767481359 -- 137,494,178(+) TATTA(A/C)AGGGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OLIG3 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV Loss 18288195
nsv5491 CNV Insertion 18451855

Variation tolerance for OLIG3 Gene

Residual Variation Intolerance Score: 39.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLIG3 Gene

HapMap Linkage Disequilibrium report
OLIG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLIG3 Gene

Disorders for OLIG3 Gene

Relevant External Links for OLIG3

Genetic Association Database (GAD)
OLIG3
Human Genome Epidemiology (HuGE) Navigator
OLIG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLIG3
genes like me logo Genes that share disorders with OLIG3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLIG3 Gene

Publications for OLIG3 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 67
  3. A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register. (PMID: 20921970) Plant D. … Thomson W. (Pharmacogenomics J. 2012) 67
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 67
  5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 67

Products for OLIG3 Gene

Sources for OLIG3 Gene

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