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Aliases for OLIG3 Gene

Aliases for OLIG3 Gene

  • Oligodendrocyte Transcription Factor 3 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 20 3 4
  • Class B Basic Helix-Loop-Helix Protein 7 3 4
  • BHLHe20 3 4
  • Bhlhb7 3 4
  • Oligo3 3 4

External Ids for OLIG3 Gene

Previous GeneCards Identifiers for OLIG3 Gene

  • GC06M137660
  • GC06M137793
  • GC06M137855
  • GC06M135375

Summaries for OLIG3 Gene

GeneCards Summary for OLIG3 Gene

OLIG3 (Oligodendrocyte Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include protein dimerization activity and RNA polymerase II transcription corepressor activity. An important paralog of this gene is OLIG2.

UniProtKB/Swiss-Prot for OLIG3 Gene

  • May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

Additional gene information for OLIG3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG3 Gene

Genomics for OLIG3 Gene

Regulatory Elements for OLIG3 Gene

Enhancers for OLIG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H137826 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -335.7 -335736 6 HDAC1 HDGF PKNOX1 RB1 KLF17 YBX1 BATF TCF12 FOS ATF7 TNFAIP3 LOC100130476 OLIG3 ENSG00000207300
GH06H137240 1.4 Ensembl ENCODE dbSUPER 9.6 +253.1 253050 2 FOXA2 ATF1 ZBTB40 THRB ZSCAN9 RARA YY1 CREM THAP11 HMG20B IFNGR1 IL22RA2 OLIG3 LOC105378017
GH06H137098 1.4 FANTOM5 ENCODE dbSUPER 9.4 +390.9 390930 8 HDGF PKNOX1 TBL1XR1 BMI1 BATF RAD21 ZNF366 ZNF143 ZNF207 ATF7 IL22RA2 IFNGR1 OLIG3 GC06P137115 IL20RA
GH06H137245 1.3 Ensembl ENCODE dbSUPER 9.6 +246.8 246814 3 PKNOX1 ZFP64 BMI1 ZBTB40 BATF ATF7 IKZF2 STAT1 L3MBTL2 TRIM22 IFNGR1 OLIG3 LOC105378017
GH06H137341 1.2 Ensembl ENCODE dbSUPER 10.3 +151.8 151822 2 CTCF MAZ MAX REST RAD21 RFX5 YY1 POLR2A SMC3 HNF4A OLIG3 LOC105378017 LOC102723633
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLIG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OLIG3 Gene

Chromosome:
6
Start:
137,492,199 bp from pter
End:
137,494,394 bp from pter
Size:
2,196 bases
Orientation:
Minus strand

Genomic View for OLIG3 Gene

Genes around OLIG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLIG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG3 Gene

Proteins for OLIG3 Gene

  • Protein details for OLIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU3-OLIG3_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 3
    Protein Accession:
    Q7RTU3
    Secondary Accessions:
    • Q8N8Q0

    Protein attributes for OLIG3 Gene

    Size:
    272 amino acids
    Molecular mass:
    29358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG3 Gene

Post-translational modifications for OLIG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OLIG3 Gene

Domains & Families for OLIG3 Gene

Gene Families for OLIG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OLIG3 Gene

Suggested Antigen Peptide Sequences for OLIG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLIG3: view

No data available for UniProtKB/Swiss-Prot for OLIG3 Gene

Function for OLIG3 Gene

Molecular function for OLIG3 Gene

UniProtKB/Swiss-Prot Function:
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

Phenotypes From GWAS Catalog for OLIG3 Gene

Gene Ontology (GO) - Molecular Function for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG3: view
genes like me logo Genes that share phenotypes with OLIG3: view

Animal Models for OLIG3 Gene

MGI Knock Outs for OLIG3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLIG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLIG3 Gene

Localization for OLIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLIG3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLIG3 Gene

Pathways & Interactions for OLIG3 Gene

SuperPathways for OLIG3 Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with OLIG3: view

Pathways by source for OLIG3 Gene

1 BioSystems pathway for OLIG3 Gene

Gene Ontology (GO) - Biological Process for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression IEA --
GO:0021520 spinal cord motor neuron cell fate specification IEA --
genes like me logo Genes that share ontologies with OLIG3: view

No data available for SIGNOR curated interactions for OLIG3 Gene

Drugs & Compounds for OLIG3 Gene

No Compound Related Data Available

Transcripts for OLIG3 Gene

mRNA/cDNA for OLIG3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLIG3 Gene

Oligodendrocyte transcription factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLIG3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG3 Gene

No ASD Table

Relevant External Links for OLIG3 Gene

GeneLoc Exon Structure for
OLIG3
ECgene alternative splicing isoforms for
OLIG3

Expression for OLIG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLIG3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLIG3 Gene



Protein tissue co-expression partners for OLIG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OLIG3 Gene:

OLIG3

SOURCE GeneReport for Unigene cluster for OLIG3 Gene:

Hs.195398
genes like me logo Genes that share expression patterns with OLIG3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLIG3 Gene

Orthologs for OLIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG3 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia OLIG3 33 34
  • 94.24 (n)
dog
(Canis familiaris)
Mammalia OLIG3 33 34
  • 93.38 (n)
oppossum
(Monodelphis domestica)
Mammalia OLIG3 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig3 33
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia Olig3 33 16 34
  • 91.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG3 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLIG3 34
  • 86 (a)
OneToOne
LOC100857919 33
  • 83.64 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia olig3 33
  • 71.1 (n)
Str.11145 33
zebrafish
(Danio rerio)
Actinopterygii olig3 33
  • 72.84 (n)
olig4 34
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-16 34
  • 29 (a)
OneToMany
Species where no ortholog for OLIG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG3 Gene

ENSEMBL:
Gene Tree for OLIG3 (if available)
TreeFam:
Gene Tree for OLIG3 (if available)

Paralogs for OLIG3 Gene

Paralogs for OLIG3 Gene

(2) SIMAP similar genes for OLIG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OLIG3: view

Variants for OLIG3 Gene

Sequence variations from dbSNP and Humsavar for OLIG3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001376852 -- 137,492,320(+) CCTAA(-/C)AAAAT utr-variant-3-prime
rs1001769031 -- 137,492,033(+) TAGTT(C/T)CAAAA downstream-variant-500B
rs1002205706 -- 137,494,470(+) TCTAT(C/G)CTGGG upstream-variant-2KB
rs1002367157 -- 137,493,293(+) GGCCC(C/G)GCACC utr-variant-3-prime
rs1002408535 -- 137,493,116(+) ACACA(C/G)GACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OLIG3 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV loss 18288195
nsv5491 CNV insertion 18451855

Variation tolerance for OLIG3 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLIG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLIG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLIG3 Gene

Disorders for OLIG3 Gene

Relevant External Links for OLIG3

Genetic Association Database (GAD)
OLIG3
Human Genome Epidemiology (HuGE) Navigator
OLIG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLIG3

No disorders were found for OLIG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLIG3 Gene

Publications for OLIG3 Gene

  1. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 45 60
  2. Genetic variants in the prediction of rheumatoid arthritis. (PMID: 20439292) van der Helm-van Mil AH … Huizinga TW (Annals of the rheumatic diseases 2010) 3 45 60
  3. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. (PMID: 20353580) Morgan AW … YEAR Consortium (Arthritis research & therapy 2010) 3 45 60
  4. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PMID: 19879194) De Jager PL … Karlson EW (The Lancet. Neurology 2009) 3 45 60
  5. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PMID: 18794853) Raychaudhuri S … Plenge RM (Nature genetics 2008) 3 45 60

Products for OLIG3 Gene

Sources for OLIG3 Gene

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