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Aliases for OLIG3 Gene

Aliases for OLIG3 Gene

  • Oligodendrocyte Transcription Factor 3 2 3
  • Bhlhb7 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 20 3 4
  • Class B Basic Helix-Loop-Helix Protein 7 3 4
  • BHLHe20 3 4
  • Oligo3 3 4

External Ids for OLIG3 Gene

Summaries for OLIG3 Gene

GeneCards Summary for OLIG3 Gene

OLIG3 (Oligodendrocyte Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is BHLHE23.

UniProtKB/Swiss-Prot for OLIG3 Gene

  • May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG3 Gene

Genomics for OLIG3 Gene

Genomic Location for OLIG3 Gene

Start:
137,492,199 bp from pter
End:
137,494,394 bp from pter
Size:
2,196 bases
Orientation:
Minus strand

Genomic View for OLIG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG3 Gene

Regulatory Elements for OLIG3 Gene

Proteins for OLIG3 Gene

  • Protein details for OLIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU3-OLIG3_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 3
    Protein Accession:
    Q7RTU3
    Secondary Accessions:
    • Q8N8Q0

    Protein attributes for OLIG3 Gene

    Size:
    272 amino acids
    Molecular mass:
    29358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG3 Gene

Proteomics data for OLIG3 Gene at MOPED

Post-translational modifications for OLIG3 Gene

No Post-translational modifications

Other Protein References for OLIG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OLIG3 Gene

Domains for OLIG3 Gene

Gene Families for OLIG3 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for OLIG3 Gene

UniProtKB/Swiss-Prot:

OLIG3_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q7RTU3
genes like me logo Genes that share domains with OLIG3: view

Function for OLIG3 Gene

Molecular function for OLIG3 Gene

UniProtKB/Swiss-Prot Function: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons

Gene Ontology (GO) - Molecular Function for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG3: view
genes like me logo Genes that share phenotypes with OLIG3: view

Animal Models for OLIG3 Gene

MGI Knock Outs for OLIG3:

miRNA for OLIG3 Gene

miRTarBase miRNAs that target OLIG3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OLIG3 Gene

Localization for OLIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLIG3 Gene COMPARTMENTS Subcellular localization image for OLIG3 gene
Compartment Confidence
golgi apparatus 3
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG3: view

Pathways for OLIG3 Gene

SuperPathways for OLIG3 Gene

genes like me logo Genes that share pathways with OLIG3: view

Pathways by source for OLIG3 Gene

1 BioSystems pathway for OLIG3 Gene

Gene Ontology (GO) - Biological Process for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression --
GO:0021520 spinal cord motor neuron cell fate specification IEA --
GO:0021522 spinal cord motor neuron differentiation --
genes like me logo Genes that share ontologies with OLIG3: view

Transcripts for OLIG3 Gene

mRNA/cDNA for OLIG3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLIG3 Gene

Oligodendrocyte transcription factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG3 Gene

No ASD Table

Relevant External Links for OLIG3 Gene

GeneLoc Exon Structure for
OLIG3
ECgene alternative splicing isoforms for
OLIG3

Expression for OLIG3 Gene

mRNA expression in normal human tissues for OLIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLIG3 Gene

SOURCE GeneReport for Unigene cluster for OLIG3 Gene Hs.195398

genes like me logo Genes that share expressions with OLIG3: view

Orthologs for OLIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG3 36
  • 99.26 (n)
  • 99.26 (a)
OLIG3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLIG3 36
  • 94.24 (n)
  • 98.9 (a)
OLIG3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG3 36
  • 93.38 (n)
  • 98.53 (a)
OLIG3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olig3 36
  • 91.18 (n)
  • 98.53 (a)
Olig3 16
Olig3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLIG3 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG3 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig3 36
  • 91.79 (n)
  • 98.9 (a)
chicken
(Gallus gallus)
Aves LOC100857919 36
  • 83.64 (n)
  • 87.08 (a)
OLIG3 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olig3 36
  • 71.1 (n)
  • 81.37 (a)
Str.11145 36
zebrafish
(Danio rerio)
Actinopterygii olig3 36
  • 72.84 (n)
  • 74.07 (a)
olig4 37
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-16 37
  • 29 (a)
OneToMany
Species with no ortholog for OLIG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG3 Gene

ENSEMBL:
Gene Tree for OLIG3 (if available)
TreeFam:
Gene Tree for OLIG3 (if available)

Paralogs for OLIG3 Gene

Paralogs for OLIG3 Gene

Selected SIMAP similar genes for OLIG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OLIG3: view

Variants for OLIG3 Gene

Sequence variations from dbSNP and Humsavar for OLIG3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6909916 -- 137,494,735(+) GAAGG(C/G)AAGAG upstream-variant-2KB
rs6909958 -- 137,494,811(+) CCTTT(C/T)TTTCC upstream-variant-2KB
rs6910320 -- 137,495,026(+) TGGGC(C/T)CTTCT upstream-variant-2KB
rs9494788 -- 137,491,941(+) TTCTC(C/G)AGTTT downstream-variant-500B
rs11154936 -- 137,496,100(+) TCTGG(C/G)CAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OLIG3 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV Loss 18288195
nsv5491 CNV Insertion 18451855

Relevant External Links for OLIG3 Gene

HapMap Linkage Disequilibrium report
OLIG3

Disorders for OLIG3 Gene

(1) University of Copenhagen DISEASES for OLIG3 Gene

Relevant External Links for OLIG3

Genetic Association Database (GAD)
OLIG3
Human Genome Epidemiology (HuGE) Navigator
OLIG3
genes like me logo Genes that share disorders with OLIG3: view

No data available for UniProtKB/Swiss-Prot for OLIG3 Gene

Publications for OLIG3 Gene

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan A.S. … Kealey T. (Mech. Dev. 2002) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. (PMID: 17982456) Plenge R.M. … Altshuler D. (Nat. Genet. 2007) 3 49

Products for OLIG3 Gene

Sources for OLIG3 Gene

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