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OLIG3 Gene

protein-coding GIFtS: 51

GC06M137855

oligodendrocyte transcription factor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BHLHB7 ^³, ⁵
Bhlhb7 ^¹, ²
OTTHUMP00000017288 ^²
Oligo3 ^³
bHLHB7 ^³
bHLHe20 ^¹, ²

Descriptions
Class B basic helix-loop-helix protein 7 ^³
oligodendrocyte transcription factor 3 ^²

External Ids
HGNC: 18003¹
Entrez Gene: 167826²
UniProtKB: Q7RTU3³
Ensembl: ENSG00000177468⁷

Search outside databases for aliases for OLIG3 gene

Previous GC identifers: GC06M137660 GC06M137793

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OLIG3_HUMAN, Q7RTU3

Function: May determine the distinct specification program of class A neurons in the dorsal part of

the spinal cord and suppress specification of class B neurons

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OLIG3 gene

Entrez Gene cytogenetic band: 6q23.3 Ensembl cytogenetic band: 6q23.3 HGNC cytogenetic band: 6q23.3

OLIG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M137855: (about GC identifiers)

Start:	137,855,029 bp from pter
End:	137,857,224 bp from pter
Size:	2,196 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OLIG3_HUMAN, Q7RTU3 (See protein sequence)

Recommended Name: Oligodendrocyte transcription factor 3

Size: 272 amino acids; 29358 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q8N8Q0

REFSEQ proteins: NP_786923.1

ENSEMBL proteins:

ENSP00000356708

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Olig3)
	Human Recombinant Proteins from Abnova (OLIG3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for OLIG3:

	Invitrogen Antibodies for OLIG3
	Millipore Mono- and Polyclonal Antibodies for the study of OLIG3
	Sigma-Aldrich Antibodies for OLIG3
	R&D Systems Antibodies for OLIG3
	Antibodies from Abcam (Olig3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OLIG3)
	Novus Biologicals Antibodies for OLIG3

Assays for OLIG3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q7RTU3

ProtoNet protein and cluster: Q7RTU3

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: OLIG3_HUMAN, Q7RTU3

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLIG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLIG3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175747

Applied Biosystems Silencer® siRNAs for OLIG3

Sigma-Aldrich siRNA for OLIG3

Sigma-Aldrich shRNA for OLIG3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OLIG3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_175747
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175747
untagged cDNA clone in CMV expression vector: NM_175747

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_175747

UniProtKB/Swiss-Prot: OLIG3_HUMAN, Q7RTU3

Function: May determine the distinct specification program of class A neurons in the dorsal part of

the spinal cord and suppress specification of class B neurons

5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Olig3):

homeostasis/metabolism

lethality-prenatal/perinatal

nervous system

no phenotypic analysis

respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLIG3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLIG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLIG3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175747

Sigma-Aldrich siRNA for OLIG3

Sigma-Aldrich shRNA for OLIG3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_175747

REFSEQ mRNAs for OLIG3 gene:

NM_175747.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_175747

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175747
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175747
                                 untagged cDNA clone in CMV expression vector: NM_175747

Additional cDNA sequence:

AK096362.1 BC051352.1

1 DOTS entry:

DT.100019023

10 AceView cDNA sequences:

AK096362 BX111291 NM_175747 BC051352 BU556497 BU855346 AI952817 AI990825

AI656498 CA337059

highest scoring ESTs for OLIG3:

AI990825 AK096362 BC051352 BU556497 BU855346 AI656498 CA844093 CA866311 CN286183 NM_175747

Unigene Cluster for OLIG3:

Oligodendrocyte transcription factor 3

Hs.195398 [show with all ESTs]

Unigene Representative Sequence: BC051352

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000367734

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OLIG3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OLIG3

¹ / ² / ³

2 probe-sets matching OLIG3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
69170_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI990825	0.80	1.00	0.91	1
1556371_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGGGTTGGC

SOURCE GeneReport for Unigene cluster: Hs.195398

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OLIG3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OLIG3¹	--	oligodendrocyte transcription factor 3	93.38(n) 98.53(a)	484005 XM_541122.2 XP_541122.1
chimpanzee (Pan troglodytes)	OLIG3¹	--	oligodendrocyte transcription factor 3	99.26(n) 99.26(a)	472134 XM_527513.2 XP_527513.2
cow (Bos taurus)	OLIG3¹	--	oligodendrocyte transcription factor 3	94.24(n) 98.9(a)	532191 XM_610701.3 XP_610701.2
rat (Rattus norvegicus)	Olig3¹	--	oligodendrocyte transcription factor 3	91.79(n) 98.9(a)	293012 XM_218772.4 XP_218772.3
mouse (Mus musculus)	Olig3^{1, 5}	10⁵	oligodendrocyte transcription factor 3^{1, 5}	91.18(n)¹ 98.53(a)¹	94222¹ NM_053008.2¹ NP_443734.2¹ AB038698⁵ BC057564⁵

About this table Species with no ortholog for OLIG3

ENSEMBL Gene Tree for OLIG3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OLIG3 gene

BHLHE22² OLIG1² BHLHE23² OLIG2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/28 NCBI SNPs in OLIG3 are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6909916^1,2	A,C,F,H	137857565(+)	`GAAGGG/CAAGAG`	1	--	ng3¹		3		EA WA	298
	rs6909958^1,2	A,C,F,H	137857641(+)	`CCTTTT/CTTTCC`	1	--	ng3¹ trp³		4		EU EA WA	416
	rs11154936^1,2	A,C	137858930(+)	`TCTGGC/GCAATA`	1	--	ng3¹		0	--	--	--	--
--	rs34331858^1,2	--	137858037(+)	`AAAAA-/ATGTTA`	1	--	ng3¹		0	--	--	--	--
--	rs34515657^1,2	--	137856427(+)	`GTTGC-/CAGATG`	1	G/	fra¹		0	--	--	--	--
--	rs35185005^1,2	--	137855377(+)	`AAGAA-/AGCGCG`	1	--	ut3¹		0	--	--	--	--
--	rs72317772^1,2	--	137854560(+)	`GTATT-/GACTATT TTCTAAGAGTGACT`	1	--	ng5¹		0	--	--	--	--
--	rs13200229^1,2	--	137858356(+)	`TGATGA/TCGGGG`	1	--	ng3¹		0	--	--	--	--
--	rs13214467^1,2	--	137858348(+)	`AAACTA/TTCTGA`	1	--	ng3¹		0	--	--	--	--
--	rs6910320^1,2	--	137857856(+)	`TGGGCC/TCTTCT`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OLIG3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609323

Human Genome Epidemiology Navigator: OLIG3 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for OLIG3 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)^{3, 4} McLellan A.S.... Kealey T. (2002)
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PubMed id 18794853)³ Raychaudhuri S....Plenge R.M. (2008)
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. (PubMed id 17982456)³ Plenge R.M....Altshuler D. (2007)
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. (PubMed id 15769945)³ Muller T....Birchmeier C. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. (PubMed id 11091082)³ Takebayashi H....Nabeshima Y. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 167826	HGNC: 18003	AceView: OLIG3	Ensembl:ENSG00000177468	euGenes: HUgn167826
ECgene: OLIG3	H-InvDB: OLIG3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OLIG3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OLIG3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OLIG3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OLIG3		Antibodies for OLIG3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OLIG3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OLIG3)
	Antibodies (OLIG3)
	Chimera RNAi (OLIG3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Olig3)
	Antibodies (Olig3)

Search OriGene for OLIG3

Search Tocris compounds for OLIG3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for OLIG3

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OLIG3 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for OLIG3

Summaries
for OLIG3

Genomic Location
for OLIG3

Proteins
for OLIG3

Protein Domains/
Families
for OLIG3

Gene Function
for OLIG3

Pathways & Interactions
for OLIG3

Drugs & Compounds
for OLIG3

Transcripts
for OLIG3

Expression
for OLIG3

Orthologs
for OLIG3

Paralogs
for OLIG3

SNPs/Variants
for OLIG3

Disorders & Mutations
for OLIG3

Medical News
for OLIG3

Publications
for OLIG3

Search for OLIG3

Genome Databases showing OLIG3

Other Databases showing OLIG3

Specialized Databases showing OLIG3

Licensable Technologies
for OLIG3

Services
for OLIG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OLIG3 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor OLIG3

Summariesfor OLIG3

Genomic Locationfor OLIG3

Proteinsfor OLIG3

Protein Domains/Familiesfor OLIG3

Gene Functionfor OLIG3

Pathways & Interactionsfor OLIG3

Drugs & Compoundsfor OLIG3

Transcriptsfor OLIG3

Expression for OLIG3

Orthologsfor OLIG3

Paralogsfor OLIG3

SNPs/Variantsfor OLIG3

Disorders & Mutationsfor OLIG3

Medical Newsfor OLIG3

Publicationsfor OLIG3

Search for OLIG3

Genome Databases showing OLIG3

Other Databases showing OLIG3

Specialized Databases showing OLIG3

Licensable Technologiesfor OLIG3

Servicesfor OLIG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OLIG3

Summaries
for OLIG3

Genomic Location
for OLIG3

Proteins
for OLIG3

Protein Domains/
Families
for OLIG3

Gene Function
for OLIG3

Pathways & Interactions
for OLIG3

Drugs & Compounds
for OLIG3

Transcripts
for OLIG3

Expression
for OLIG3

Orthologs
for OLIG3

Paralogs
for OLIG3

SNPs/Variants
for OLIG3

Disorders & Mutations
for OLIG3

Medical News
for OLIG3

Publications
for OLIG3

Licensable Technologies
for OLIG3

Services
for OLIG3