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OLIG2 Gene

protein-coding   GIFtS: 60
GCID: GC21P034398

Oligodendrocyte Lineage Transcription Factor 2

(Previous name: protein kinase C binding protein 2)
(Previous symbols: PRKCBP2, BHLHB1)
  See OLIG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oligodendrocyte Lineage Transcription Factor 21 2     Basic Domain1
PRKCBP21 2 3 5     Class B1
BHLHB11 2 3     Helix-Loop-Helix Protein1
Human Protein Kinase C-Binding Protein RACK171 2     Protein Kinase C Binding Protein 21
Oligodendrocyte-Specific BHLH Transcription Factor 21 2     OLIGO22
Class B Basic Helix-Loop-Helix Protein 12 3     Basic Domain, Helix-Loop-Helix Protein, Class B, 12
Class E Basic Helix-Loop-Helix Protein 192 3     Oligodendrocyte Transcription Factor 22
Protein Kinase C-Binding Protein 22 3     BHLHE193
RACK172 3     Oligo23
bHLHe192 3     bHLHb13
11     Protein Kinase C-Binding Protein RACK173

External Ids:    HGNC: 93981   Entrez Gene: 102152   Ensembl: ENSG000002059277   OMIM: 6063865   UniProtKB: Q135163   

Export aliases for OLIG2 gene to outside databases

Previous GC identifers: GC21P030975 GC21P033318 GC21P033320 GC21P019809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OLIG2 Gene:
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of
the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is
involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia.
Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning
deficits associated with Down syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for OLIG2 Gene:
OLIG2 (oligodendrocyte lineage transcription factor 2) is a protein-coding gene. Diseases associated with OLIG2 include papillary glioneuronal tumor, and dysembryoplastic neuroepithelial tumor. GO annotations related to this gene include HMG box domain binding and protein homodimerization activity. An important paralog of this gene is BHLHE22.

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the
development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the
embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By
similarity)

Gene Wiki entry for OLIG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OLIG2 gene promoter:
         Elk-1   FOXF2   SREBP-1c   LCR-F1   SREBP-1b   GATA-2   SREBP-1a   FOXO4   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLIG2 promoter sequence
   Search Chromatin IP Primers for OLIG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLIG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

OLIG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLIG2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P034398:  view genomic region     (about GC identifiers)

Start:
34,398,153 bp from pter      End:
34,401,504 bp from pter
Size:
3,352 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516 (See protein sequence)
Recommended Name: Oligodendrocyte transcription factor 2  
Size: 323 amino acids; 32385 Da
Subunit: Interacts with NKX2-2 (By similarity)
Sequence caution: Sequence=AAC72247.1; Type=Erroneous initiation; Sequence=AAF61215.1; Type=Erroneous initiation;
Secondary accessions: B3KRF3 Q86X04 Q9NZ14

Explore the universe of human proteins at neXtProt for OLIG2: NX_Q13516

Explore proteomics data for OLIG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OLIG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005797.1  
    ENSEMBL proteins: 
     ENSP00000371794   ENSP00000391183   ENSP00000331040  

    OLIG2 Human Recombinant Protein Products:

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    antibodies-online proteins for OLIG2 (5 products) 

     
    antibodies-online peptides for OLIG2

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    antibodies-online antibodies for OLIG2 (97 products) 

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    antibodies-online kits for OLIG2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q13516

    ProtoNet protein and cluster: Q13516

    2 Blocks protein domains:
    IPB000408 Regulator of chromosome condensation
    IPB001092 Basic helix-loop-helix dimerization domain bHLH


    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
    Domain: The bHLH is essential for interaction with NKX2-2 (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with OLIG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLIG2_HUMAN, Q13516
    Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the
    development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the
    embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By
    similarity)
    Induction: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
    GO:0046983protein dimerization activity ----
         
    Find genes that share ontologies with OLIG2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OLIG2:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Olig2):
     adipose tissue  behavior/neurological  cellular  growth/size/body  mortality/aging 
     muscle  nervous system  no phenotypic analysis  respiratory system  skeleton 
     tumorigenesis  vision/eye 

    Find genes that share phenotypes with OLIG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Olig2tm1Rth for OLIG2

       genOway: Develop your customized and physiologically relevant rodent model for OLIG2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  RCCATMTGTT 

    miRNA
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    miRTarBase miRNAs that target OLIG2:
    hsa-mir-218-5p (MIRT024220)

    Block miRNA regulation of human, mouse, rat OLIG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLIG2 (see all 13):
    hsa-miR-374b* hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-3120-3p hsa-miR-507 hsa-miR-182* hsa-miR-656 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidOLIG2 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for OLIG2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OLIG2_HUMAN, Q13516: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH
    domain could be masked in the native form and translocation to the nucleus could be mediated by interaction
    either with class E bHLH partner protein or with NKX2-2 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with OLIG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OLIG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2Neural Crest Differentiation
    Neural Crest Differentiation


    1 BioSystems Pathway for OLIG2
        Neural Crest Differentiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including OLIG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OLIG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OLIG2 (Q135163 ENSP000003310404) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    NKX2-2O950963, ENSP000003663474I2D: score=2 STRING: ENSP00000366347
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007399nervous system development ----
    GO:0021522spinal cord motor neuron differentiation IEA--
    GO:0021529spinal cord oligodendrocyte cell differentiation ----
    GO:0021530spinal cord oligodendrocyte cell fate specification IEA--

    Find genes that share ontologies with OLIG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OLIG2

    1 Novoseek inferred chemical compound relationship for OLIG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 19.7 2 14743441 (1), 19544414 (1)



    Find genes that share compounds with OLIG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OLIG2 gene: 
    NM_005806.3  

    Unigene Cluster for OLIG2:

    Oligodendrocyte lineage transcription factor 2
    Hs.176977  [show with all ESTs]
    Unigene Representative Sequence: BC036245
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382357(uc002yqx.2) ENST00000430860 ENST00000333337(uc021wil.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat OLIG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OLIG2 (see all 13):
    hsa-miR-374b* hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-3120-3p hsa-miR-507 hsa-miR-182* hsa-miR-656 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidOLIG2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF221520.1 AK091462.1 BC034681.1 BC036245.1 BC036275.1 BC047511.1 U48250.1 

    7 DOTS entries:

    DT.85105306  DT.91651057  DT.95119479  DT.121132166  DT.121132151  DT.80101759  DT.95363865 

    Selected AceView cDNA sequences (see all 88):

    AK091462 AW510628 NM_005806 AI360012 AI277362 AI566559 BG910423 AI536683 
    BG820163 BG820341 BC047511 BF530691 BF346679 AI880044 AI369652 AW149778 
    AI553817 BG911447 BX461924 BC034681 BE857066 AI375346 AI421302 AI871088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OLIG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGATTC
    OLIG2 Expression
    About this image


    OLIG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 41 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Pre-oligodendrocyte progenitor cells
     
     Spinal Cord (Nervous System)    fully expand to see all 21 entries
             Oligodendrocyte Precursor Cells Spinal Cord White Matter
             Fetal spinal cord stem cells (NSI-566)
             Motor neuron progenitors
     
     Neural Tube (Nervous System)    fully expand to see all 17 entries
             Late MN Progenitor Cells Motor Neural Progenitor Domain
             Telencephalon
     
     Oligodendrocytes (Nervous System)    fully expand to see all 10 entries
             Pre-oligodendrocyte progenitor cells
     
     Motor Neurons (Nervous System)    fully expand to see all 5 entries
             Motor neurons progenitors
    OLIG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OLIG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.176977

    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
    Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while
    expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OLIG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat OLIG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for OLIG2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olig21 , 5 oligodendrocyte transcription factor 21, 5 88.13(n)1
    96.28(a)1
      16 (52.60 cM)5
    509131  NM_016967.21  NP_058663.21 
     912255505 
    chicken
    (Gallus gallus)
    Aves OLIG31 oligodendrocyte transcription factor 3 79.54(n)
    79.31(a)
      428612  NM_001031526.1  NP_001026697.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151932 Xenopus laevis transcribed sequence with weak similarity more 74.04(n)    BJ037458.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF442964.12   -- 77.29(n)   325288  AF442964.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-166
    Protein HLH-16 (hlh-16) mRNA, complete cds
    30(a)
    1 → many
    I(8767019-8768028) WBGene00001960


    ENSEMBL Gene Tree for OLIG2 (if available)
    TreeFam Gene Tree for OLIG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OLIG2 gene
    BHLHE222  OLIG32  OLIG12  BHLHE232  
    2 SIMAP similar genes for OLIG2 using alignment to 4 protein entries:     OLIG2_HUMAN (see all proteins):
    OLIG3    BHLHE23

    Find genes that share paralogs with OLIG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OLIG2 (see all 109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829210841,2
    --24942468(+) TGGCGC/GGGTAG 1 -- us2k10--------
    rs1872614091,2
    C--24942479(+) GCCCGA/TAGGAG 1 -- us2k10--------
    rs119089711,2
    C,F,H--24942525(+) CCCCCC/TCGCTC 1 -- us2k12Minor allele frequency- T:0.50NA WA 6
    rs1918449641,2
    C--24942739(+) GGGCTC/TCTAGC 1 -- us2k10--------
    rs765300591,2
    C,F--24942746(+) TAGCGG/TAGACC 1 -- us2k13Minor allele frequency- T:0.14NA CSA WA 130
    rs99750391,2
    C,F--24942837(+) TGAAGA/GCCAAT 1 -- us2k1 tfbs37Minor allele frequency- G:0.16NA WA EA 366
    rs1843928901,2
    --24942924(+) CCCGAC/TGTTCC 1 -- us2k10--------
    rs1891036871,2
    --24942925(+) CCGACG/TTTCCT 1 -- us2k10--------
    rs1485544151,2
    C--24942959(+) CGTGTA/GTGCCC 1 -- us2k10--------
    rs758477651,2
    C,F--24943018(+) CAAATG/TTCTGA 1 -- us2k12Minor allele frequency- T:0.11CSA WA 120

    HapMap Linkage Disequilibrium report for OLIG2 (34398153 - 34401504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OLIG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520925CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OLIG2
    DNA2.0 Custom Variant and Variant Library Synthesis for OLIG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606386    OMIM disorders: --

    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
  • Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic
    leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA

  • 6 diseases for OLIG2:    
    About MalaCards
    papillary glioneuronal tumor    dysembryoplastic neuroepithelial tumor    lymphoblastic leukemia    astrocytoma
    down syndrome    pilocytic astrocytoma

    4 diseases from the University of Copenhagen DISEASES database for OLIG2:
    Malignant glioma     Dysembryoplastic neuroepithelial tumor     Multiple sclerosis     Brain cancer

    Find genes that share disorders with OLIG2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for OLIG2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligodendroglial tumors 84.4 5 16598485 (1), 15111318 (1), 12924709 (1), 17415208 (1) (see all 5)
    oligodendroglioma 81.5 15 14575240 (3), 18552083 (2), 14730454 (2), 19618851 (1) (see all 11)
    anaplastic oligodendroglioma 73.2 6 14575240 (3), 14730454 (1), 15198128 (1)
    neurocytoma central 66.7 5 17257132 (5)
    astrocytoma 63.7 10 18552083 (2), 15198128 (2), 16598485 (1), 17146289 (1) (see all 7)
    pilocytic astrocytoma 62.2 3 12924709 (1), 18312545 (1), 17442061 (1)
    glioblastoma 61.3 8 14575240 (2), 14730454 (1), 15198128 (1), 15164981 (1) (see all 6)
    anaplastic astrocytoma 57.5 5 14575240 (2), 14730454 (1), 17917751 (1), 17415208 (1)
    demyelination 53.8 2 15519240 (2)
    glioma 53.1 23 14575240 (5), 15198128 (4), 15634232 (2), 18282166 (2) (see all 8)

    Genetic Association Database (GAD): OLIG2
    Human Genome Epidemiology (HuGE) Navigator: OLIG2 (5 documents)

    Export disorders for OLIG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OLIG2 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with OLIG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PubMed id 11526205)1, 2, 3 Lu Q.R.... Black P.M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PubMed id 17283288)1, 4, 9 Stewart S.E....Pauls D.L. (Arch. Gen. Psychiatry 2007)
    3. The t(14;21)(q11.2;q22) chromosomal translocation associated with T- cell acute lymphoblastic leukemia activates the BHLHB1 gene. (PubMed id 10737801)1, 2, 9 Wang J.... Aplan P.D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. (PubMed id 19477230)1, 4 Sims R....Abraham R. (Neurosci. Lett. 2009)
    5. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. (PubMed id 16891421)1, 4 Georgieva L....O'Donovan M.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    6. The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. (PubMed id 17010574)1, 4 Usui H....Ozaki N. (Schizophr. Res. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. OLIG2 as a specific marker of oligodendroglial tumour cells. (PubMed id 11498220)1, 2 Marie Y.... Hoang-Xuan K. (Lancet 2001)
    10. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. (PubMed id 16103065)1, 9 Lin Y.W....Aplan P.D. (Cancer Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10215 HGNC: 9398 AceView: OLIG2 Ensembl:ENSG00000205927 euGenes: HUgn10215
    ECgene: OLIG2 H-InvDB: OLIG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OLIG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OLIG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OLIG2 gene:
    Search GeneIP for patents involving OLIG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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