Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLIG2 Gene

protein-coding   GIFtS: 60
GCID: GC21P034398

oligodendrocyte lineage transcription factor 2

(Previous name: protein kinase C binding protein 2 )
(Previous symbols: PRKCBP2, BHLHB1)
 Explore 19 diseases affiliated with
OLIG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OLIG2    

Aliases
for OLIG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Oligodendrocyte Lineage Transcription Factor 21 2     Protein Kinase C Binding Protein 21
PRKCBP21 2 3 5     Basic Domain, Helix-Loop-Helix Protein, Class B, 12
BHLHB11 2 3     Human Protein Kinase C-Binding Protein RACK172
RACK171 2 3     Oligodendrocyte Transcription Factor 22
BHLHe191     Oligodendrocyte-Specific BHLH Transcription Factor 22
OLIGO21 2     BHLHE193
Class B Basic Helix-Loop-Helix Protein 12 3     Oligo23
Class E Basic Helix-Loop-Helix Protein 192 3     BHLHb11
Protein Kinase C-Binding Protein 22 3     Protein Kinase C-Binding Protein RACK173

External Ids:    HGNC: 93981   Entrez Gene: 102152   Ensembl: ENSG000002059277   OMIM: 6063865   UniProtKB: Q135163   

Export aliases for OLIG2 gene to outside databases

Previous GC identifers: GC21P030975 GC21P033318 GC21P033320 GC21P019809


Summaries
for OLIG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OLIG2:
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the
brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in
a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal
location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated
with Down syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the
development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the
embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity)

Gene Wiki entry for OLIG2


Genomic Views
for OLIG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLIG2 gene promoter:
         Elk-1   FOXF2   SREBP-1c   LCR-F1   SREBP-1b   GATA-2   SREBP-1a   FOXO4   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OLIG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OLIG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLIG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

OLIG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLIG2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P034398:  view genomic region     (about GC identifiers)

Start:
 34,398,153 bp from pter      End:
 34,401,504 bp from pter
Size:
 3,352 bases      Orientation:
 plus strand

Proteins
for OLIG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516 (See protein sequence)
Recommended Name: Oligodendrocyte transcription factor 2  
Size: 323 amino acids; 32385 Da
Subunit: Interacts with NKX2-2 (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain
could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class
E bHLH partner protein or with NKX2-2 (By similarity)
Sequence caution: Sequence=AAC72247.1; Type=Erroneous initiation; Sequence=AAF61215.1; Type=Erroneous initiation;
Secondary accessions: B3KRF3 Q86X04 Q9NZ14

Explore the universe of human proteins at neXtProt for OLIG2: NX_Q13516

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13516

    • OLIG2 Protein expression data from MOPED and PaxDb:    About this image 
    OLIG2 Protein Expression
    REFSEQ proteins: NP_005797.1  
    ENSEMBL proteins: 
     ENSP00000371794   ENSP00000331040   ENSP00000391183  

    Human Recombinant Protein Products for OLIG2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: OLIG2
    OriGene Protein Over-expression Lysate: OLIG2
    OriGene Custom Protein Services for OLIG2 
    GenScript Custom Purified and Recombinant Proteins Services for OLIG2
    Novus Biologicals OLIG2 Protein
    Novus Biologicals OLIG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OLIG2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----

    OLIG2 for ontologies           About GeneDecksing



    OLIG2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of OLIG2
    R&D Systems Antibodies for OLIG2
    OriGene Antibodies: OLIG2
    OriGene Custom Antibody Services for OLIG2 
    GenScript Superior Antibodies for OLIG2
    Novus Biologicals OLIG2 Antibodies
    Abcam antibodies for OLIG2 
    Uscn Antibodies for OLIG2
    ThermoFisher Antibody for OLIG2

    Assay Products for OLIG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for OLIG2
    GenScript Custom Assay Services for OLIG2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for OLIG2

    Protein Domains /
    Families
    for OLIG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OLIG2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q13516

    ProtoNet protein and cluster: Q13516

    2 Blocks protein families:
    IPB000408 Regulator of chromosome condensation
    IPB001092 Basic helix-loop-helix dimerization domain bHLH


    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
    Domain: The bHLH is essential for interaction with NKX2-2 (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for OLIG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OLIG2_HUMAN, Q13516
    Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the
    development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the
    embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity)
    Induction: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By
    similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    OLIG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OLIG2:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Olig2):
     adipose tissue  behavior/neurological  cellular  growth/size  mortality/aging 
     muscle  nervous system  no phenotypic analysis  respiratory system  skeleton 
     tumorigenesis  vision/eye 

    OLIG2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Olig2tm1Rth for OLIG2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OLIG2 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: OLIG2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLIG2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate OLIG2 (see all 13):
    hsa-miR-374b* hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-3120-3p hsa-miR-507 hsa-miR-182* hsa-miR-656 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmid: OLIG2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLIG2 (see all 4)
    OriGene shRNA RFP: OLIG2
    OriGene siRNA: OLIG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLIG2
    Sirion Biotech Custom design and validation of potent shRNA sequences against OLIG2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OLIG2
    Sirion Biotech Customized adenovirus for overexpression of OLIG2 
    Sirion Biotech Customized adenovirus for potent knockdown of OLIG2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OLIG2 (NM_005806)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLIG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLIG2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for OLIG2
    Search LifeMap BioReagents cell lines for OLIG2
    Sirion Biotech Customized stable knockdown cell line services for OLIG2 
    Sirion Biotech Customized inducible knockdown cell line services for OLIG2
    Sirion Biotech Customized stable overexpressing cell line services for OLIG2
    Sirion Biotech Customized inducible overexpressing cell line services for OLIG2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG2


    Pathways & Interactions
    for OLIG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    2Neural Crest Differentiation
    		Neural Crest Differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for OLIG2
        Transcription factors in neurogenesis


    1 BioSystems Pathway for OLIG2 
        Neural Crest Differentiation



    OLIG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OLIG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for OLIG2 (Q135163 ENSP000003310404) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    NKX2-2O950963, ENSP000003663474I2D: score=2 STRING: ENSP00000366347
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007399nervous system development ----
    GO:0021522spinal cord motor neuron differentiation IEA--
    GO:0021529spinal cord oligodendrocyte cell differentiation ----

    OLIG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OLIG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OLIG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLIG2
    1 Novoseek chemical compound relationship for OLIG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 19.7 2 14743441 (1), 19544414 (1)

    Search CenterWatch for drugs/clinical trials and news about OLIG2 

    Transcripts
    for OLIG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OLIG2 gene: 
    NM_005806.3  

    Unigene Cluster for OLIG2:

    Oligodendrocyte lineage transcription factor 2
    Hs.176977  [show with all ESTs]
    Unigene Representative Sequence: BC036245
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382357(uc002yqx.2) ENST00000333337(uc021wil.1) ENST00000430860


    miRNA
    Products:             		 OriGene 3'-UTR Clone: OLIG2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OLIG2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate OLIG2 (see all 13):
    hsa-miR-374b* hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-3120-3p hsa-miR-507 hsa-miR-182* hsa-miR-656 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmid: OLIG2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLIG2 (see all 4)
    OriGene shRNA RFP: OLIG2
    OriGene siRNA: OLIG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLIG2
    Sirion Biotech Custom design and validation of potent shRNA sequences against OLIG2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: OLIG2 (NM_005806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OLIG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLIG2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OLIG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLIG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLIG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLIG2

    Additional cDNA sequence: 

    AF221520.1 AK091462.1 BC034681.1 BC036245.1 BC036275.1 BC047511.1 U48250.1 

    7 DOTS entries:

    DT.85105306  DT.91651057  DT.95119479  DT.121132166  DT.121132151  DT.80101759  DT.95363865 

    24/88 AceView cDNA sequences (see all 88):

    BG820341 BG910423 AI536683 AI277362 AW510628 AK091462 NM_005806 AI566559 
    AI360012 BG820163 AW136218 AI570612 BC047511 BF530589 BC036245 BF516315 
    BG910780 BI544712 AI369425 AI566781 BF515096 BF530691 AW149778 BX461924 

    GeneLoc Exon Structure


    Expression
    for OLIG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLIG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGGATTC
    OLIG2 Expression
    About this image

    OLIG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordMotor Neural Progenitor DomainMotor Neural Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    Fetal spinal cord stem cells (NSI-566) (Fetal Stem / Progenitor Cell)Spinal Cord
    GABA neuron-like cells (Generation of motor ...)Brain
    Motor neuron-like cells (Generation of motor ...)
    Motor neurons progenitors (Motor neuron differe...)
    Motor neuron progenitors (Differentiation of ...)
    Motor neuron progenitors (Spinal motor neurons...)
    Motor neuron-like cells (Spinal motor neurons...)

    See OLIG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLIG2

    SOURCE GeneReport for Unigene cluster: Hs.176977

    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
    Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while
    expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable

        SABiosciences Expression via Pathway-Focused PCR Arrays including OLIG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OLIG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OLIG2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLIG2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLIG2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG2

    Orthologs
    for OLIG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OLIG2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves OLIG31 oligodendrocyte transcription factor 3 82.99(n)
    86.55(a)    		   428612  NM_001031526.1  NP_001026697.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.151932 Xenopus laevis transcribed sequence with weak similarity more 74.04(n)    BJ037458.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF442964.12   -- 77.29(n)   325288  AF442964.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-166
    		 Helix Loop Helix family member (hlh-16)
    		 27(a)
    		 1 → many
    		 I(8767013-8768022)


    ENSEMBL Gene Tree for OLIG2 (if available)
    TreeFam Gene Tree for OLIG2 (if available) 

    Paralogs
    for OLIG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLIG2 gene
    OLIG32  BHLHE222  BHLHE232  OLIG12  
    2 SIMAP similar genes for OLIG2 using alignment to 4 protein entries:     OLIG2_HUMAN (see all proteins):
    OLIG3    BHLHE23

    OLIG2 for paralogs           About GeneDecksing



    Genomic Variants
    for OLIG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/78 NCBI SNPs in OLIG2 are shown (see all 78)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119089711,2
    		C,F,H--19807502(+) CCCCCC/TCGCTC 1 -- us2k12Minor allele frequency- T:0.50NA WA 6
    rs765300591,2
    		C,F--19807723(+) TAGCGG/TAGACC 1 -- us2k13Minor allele frequency- T:0.14NA CSA WA 130
    rs758477651,2
    		--19807995(+) CAAATG/TTCTGA 1 -- us2k12Minor allele frequency- T:0.11CSA WA 120
    rs746029491,2
    		F--19808263(+) TCATCG/ATCAAG 1 -- us2k13Minor allele frequency- A:0.14NA CSA WA 128
    rs65171351,2
    		C,F,A,H--19808793(+) GGCCAT/CCTCCT 1 -- us2k1 tfbs323Minor allele frequency- C:0.37NS EA NA WA CSA 2350
    rs802143341,2
    		--19809840(+) CCCGCG/ACCGGC 1 -- int12Minor allele frequency- A:0.14CSA WA 120
    rs11228071,2
    		C,F--19810015(+) CCCACA/TCCTAA 1 -- int1 ese34Minor allele frequency- T:0.40NA CSA WA 123
    rs760797861,2
    		C,F--19810038(+) AGCCTC/ATAGAA 1 -- int11Minor allele frequency- A:0.06WA 118
    rs802647631,2
    		F--19810319(+) TTTCTC/GCTCCT 1 -- int11Minor allele frequency- G:0.12WA 118
    rs758866991,2
    		C,F--19811429(+) GAGGAC/TTGGCC 1 -- ut311Minor allele frequency- T:0.12WA 118

    HapMap Linkage Disequilibrium report for OLIG2 (34398153 - 34401504 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OLIG2
         1 CNV: 50770

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OLIG2
    DNA2.0 Custom Variant and Variant Library Synthesis for OLIG2

    Disorders / Diseases
    for OLIG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OLIG2 for disorders           About GeneDecksing

    OMIM gene information: 606386    OMIM disorders: --

    UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
  • Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia
    • (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA

    19 diseases for OLIG2:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    obsessive-compulsive disorder    dysembryoplastic neuroepithelial tumor
    leukemia    anaplastic oligodendroglioma    pilocytic astrocytoma    central neurocytoma
    anaplastic astrocytoma    oligodendroglioma    down syndrome    astrocytoma
    brain injury    malignant glioma    leukodystrophy    multiple sclerosis
    glioblastoma    schizophrenia    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for OLIG2:
    Malignant glioma     Dysembryoplastic neuroepithelial tumor     Multiple sclerosis

    10/14 Novoseek disease relationships for OLIG2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligodendroglial tumors 84.4 5 16598485 (1), 15111318 (1), 12924709 (1), 17415208 (1) (see all 5)
    oligodendroglioma 81.5 15 14575240 (3), 18552083 (2), 14730454 (2), 19618851 (1) (see all 11)
    anaplastic oligodendroglioma 73.2 6 14575240 (3), 14730454 (1), 15198128 (1)
    neurocytoma central 66.7 5 17257132 (5)
    astrocytoma 63.7 10 18552083 (2), 15198128 (2), 16598485 (1), 17146289 (1) (see all 7)
    pilocytic astrocytoma 62.2 3 12924709 (1), 18312545 (1), 17442061 (1)
    glioblastoma 61.3 8 14575240 (2), 14730454 (1), 15198128 (1), 15164981 (1) (see all 6)
    anaplastic astrocytoma 57.5 5 14575240 (2), 14730454 (1), 17917751 (1), 17415208 (1)
    demyelination 53.8 2 15519240 (2)
    glioma 53.1 23 14575240 (5), 15198128 (4), 15634232 (2), 18282166 (2) (see all 8)

    Human Genome Epidemiology (HuGE) Navigator: OLIG2 (5 documents)

    Export disorders for OLIG2 gene to outside databases

    Publications
    for OLIG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLIG2 gene, integrated from 9 sources (see all 126):
    (articles sorted by number of sources associating them with OLIG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PubMed id 11526205)1, 2, 3 Lu Q.R.... Black P.M. (2001)
    2. The t(14;21)(q11.2;q22) chromosomal translocation associated with T- cell acute lymphoblastic leukemia activates the BHLHB1 gene. (PubMed id 10737801)1, 2, 9 Wang J.... Aplan P.D. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. OLIG2 as a specific marker of oligodendroglial tumour cells. (PubMed id 11498220)1, 2 Marie Y.... Hoang-Xuan K. (2001)
    6. OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. (PubMed id 16103065)1, 9 Lin Y.W....Aplan P.D. (2005)
    7. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. (PubMed id 15198128)1, 9 Ligon K.L....Rowitch D.H. (2004)
    8. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PubMed id 17283288)1, 9 Stewart S.E....Pauls D.L. (2007)
    9. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. (PubMed id 16469306)1, 9 Sun T....Rowitch D.H. (2006)
    10. Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. (PubMed id 16267213)1, 9 Jakovcevski I. and Zecevic N. (2005)

    External Searches for OLIG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OLIG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10215 HGNC: 9398 AceView: OLIG2 Ensembl:ENSG00000205927 euGenes: HUgn10215
    ECgene: OLIG2 H-InvDB: OLIG2

    Other Databases showing OLIG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OLIG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLIG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OLIG2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for OLIG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OLIG2 gene:
    Search GeneIP for patents involving OLIG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OLIG2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of OLIG2
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for OLIG2 (Olig2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays for OLIG2 (Olig2)  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for OLIG2   OriGene shRNA RFP for OLIG2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OLIG2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OLIG2  
     OriGene Protein Over-expression Lysate for OLIG2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for OLIG2   OriGene 3'-UTR Clone for OLIG2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OLIG2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for OLIG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OLIG2   OriGene Custom Protein Services for OLIG2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OLIG2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OLIG2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLIG2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OLIG2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLIG2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLIG2
     GenScript Custom Purified and Recombinant Proteins Services for OLIG2 GenScript cDNA clones with any tag delivered in your preferred vector for OLIG2
     GenScript Custom Assay Services for OLIG2 GenScript Superior Antibodies for OLIG2
     GenScript Custom overexpressing Cell Line Services for OLIG2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OLIG2 promoter
     Search Chromatin IP Primers for OLIG2
     RT2 qPCR Primer Assay in human, mouse, rat OLIG2
     GNC Network for OLIG2
     SABiosciences PCR Arrays including human, mouse, rat OLIG2
     Search Tocris compounds for OLIG2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OLIG2 antibodies
     OLIG2 proteins
     OLIG2 lysates
     Antibodies for OLIG2
     See all of Abcam's Antibodies, Kits and Proteins for OLIG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     OLIG2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for OLIG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG2
     SwitchGear 3'UTR luciferase reporter plasmids for OLIG2
     SwitchGear Promoter luciferase reporter plasmids for OLIG2
     ThermoFisher Antibody for OLIG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLIG2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OLIG2
    Sirion Biotech Customized:
     stable knockdown cell line services for OLIG2
     inducible knockdown cell line services for OLIG2
     design and validation of potent shRNA sequences against OLIG2
     adenovirus for potent knockdown of OLIG2
     adenovirus for overexpression of OLIG2
     stable overexpressing cell line services for OLIG2
     inducible overexpressing cell line services for OLIG2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      OLIG2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4