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Aliases for OLIG2 Gene

Aliases for OLIG2 Gene

  • Oligodendrocyte Lineage Transcription Factor 2 2 3
  • PRKCBP2 3 4 6
  • Oligodendrocyte-Specific BHLH Transcription Factor 2 2 3
  • Human Protein Kinase C-Binding Protein RACK17 2 3
  • Class E Basic Helix-Loop-Helix Protein 19 3 4
  • Class B Basic Helix-Loop-Helix Protein 1 3 4
  • Protein Kinase C Binding Protein 2 2 2
  • Protein Kinase C-Binding Protein 2 3 4
  • BHLHe19 3 4
  • OLIGO2 3 4
  • BHLHB1 3 4
  • RACK17 3 4
  • Basic Domain, Helix-Loop-Helix Protein, Class B, 1 3
  • Protein Kinase C-Binding Protein RACK17 4
  • Oligodendrocyte Transcription Factor 2 3
  • Helix-Loop-Helix Protein 2
  • Basic Domain 2
  • Class B 2
  • 1 2

External Ids for OLIG2 Gene

Previous Symbols for OLIG2 Gene

  • PRKCBP2
  • BHLHB1

Summaries for OLIG2 Gene

Entrez Gene Summary for OLIG2 Gene

  • This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for OLIG2 Gene

OLIG2 (Oligodendrocyte Lineage Transcription Factor 2) is a Protein Coding gene. Diseases associated with OLIG2 include lymphoblastic leukemia and astrocytoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include protein homodimerization activity and HMG box domain binding. An important paralog of this gene is BHLHE23.

UniProtKB/Swiss-Prot for OLIG2 Gene

  • Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).

Gene Wiki entry for OLIG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG2 Gene

Genomics for OLIG2 Gene

Genomic Location for OLIG2 Gene

Start:
33,025,845 bp from pter
End:
33,029,196 bp from pter
Size:
3,352 bases
Orientation:
Plus strand

Genomic View for OLIG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG2 Gene

Regulatory Elements for OLIG2 Gene

Proteins for OLIG2 Gene

  • Protein details for OLIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13516-OLIG2_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 2
    Protein Accession:
    Q13516
    Secondary Accessions:
    • B3KRF3
    • Q05BP9
    • Q49AL3
    • Q86X04
    • Q9NZ14

    Protein attributes for OLIG2 Gene

    Size:
    323 amino acids
    Molecular mass:
    32385 Da
    Quaternary structure:
    • Interacts with NKX2-2.
    SequenceCaution:
    • Sequence=AAC72247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF61215.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG2 Gene

Proteomics data for OLIG2 Gene at MOPED

Post-translational modifications for OLIG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OLIG2 Gene

Domains for OLIG2 Gene

Gene Families for OLIG2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

UniProtKB/Swiss-Prot:

OLIG2_HUMAN
Domain:
  • The bHLH is essential for interaction with NKX2-2.:
    • Q13516
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q13516
genes like me logo Genes that share domains with OLIG2: view

Function for OLIG2 Gene

Molecular function for OLIG2 Gene

UniProtKB/Swiss-Prot Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
UniProtKB/Swiss-Prot Induction: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).

Gene Ontology (GO) - Molecular Function for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
GO:0046983 protein dimerization activity --
genes like me logo Genes that share ontologies with OLIG2: view
genes like me logo Genes that share phenotypes with OLIG2: view

Animal Models for OLIG2 Gene

MGI Knock Outs for OLIG2:

miRNA for OLIG2 Gene

miRTarBase miRNAs that target OLIG2
Targeting motifs for OLIG2 Gene
HOMER Transcription Factor Regulatory Elements motif OLIG2
  • Consensus sequence: RCCATMTGTT Submotif: canonical Cell Type: Neuron GeoId: GSE30882

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for OLIG2 Gene

Localization for OLIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG2 Gene

Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLIG2 Gene COMPARTMENTS Subcellular localization image for OLIG2 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with OLIG2: view

Pathways for OLIG2 Gene

SuperPathways for OLIG2 Gene

genes like me logo Genes that share pathways with OLIG2: view

Pathways by source for OLIG2 Gene

1 BioSystems pathway for OLIG2 Gene

Gene Ontology (GO) - Biological Process for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007399 nervous system development --
GO:0021522 spinal cord motor neuron differentiation IEA --
GO:0021529 spinal cord oligodendrocyte cell differentiation --
genes like me logo Genes that share ontologies with OLIG2: view

Compounds for OLIG2 Gene

(1) Novoseek inferred chemical compound relationships for OLIG2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 19.7 2
genes like me logo Genes that share compounds with OLIG2: view

Transcripts for OLIG2 Gene

Unigene Clusters for OLIG2 Gene

Oligodendrocyte lineage transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG2 Gene

No ASD Table

Relevant External Links for OLIG2 Gene

GeneLoc Exon Structure for
OLIG2
ECgene alternative splicing isoforms for
OLIG2

Expression for OLIG2 Gene

mRNA expression in normal human tissues for OLIG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLIG2 Gene

This gene is overexpressed in Brain - Substantia nigra (6.5), Brain - Amygdala (6.4), Brain - Hippocampus (5.8), Brain - Putamen (basal ganglia) (5.4), Brain - Spinal cord (cervical c-1) (5.2), Brain - Hypothalamus (4.6), and Brain - Caudate (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OLIG2 Gene

SOURCE GeneReport for Unigene cluster for OLIG2 Gene Hs.176977

mRNA Expression by UniProt/SwissProt for OLIG2 Gene

Q13516-OLIG2_HUMAN
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
genes like me logo Genes that share expressions with OLIG2: view

Orthologs for OLIG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG2 36
  • 99.28 (n)
  • 100 (a)
OLIG2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG2 36
  • 90.82 (n)
  • 96.28 (a)
OLIG2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olig2 36
  • 88.13 (n)
  • 96.28 (a)
Olig2 16
Olig2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLIG2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig2 36
  • 88.44 (n)
  • 96.28 (a)
chicken
(Gallus gallus)
Aves OLIG2 37
  • 81 (a)
OneToOne
OLIG3 36
  • 79.54 (n)
  • 79.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15193 36
tropical clawed frog
(Silurana tropicalis)
Amphibia olig2 36
  • 74.76 (n)
  • 81.36 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
olig2 36
  • 67.92 (n)
  • 68.16 (a)
olig2 37
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-16 37
  • 30 (a)
OneToMany
Species with no ortholog for OLIG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG2 Gene

ENSEMBL:
Gene Tree for OLIG2 (if available)
TreeFam:
Gene Tree for OLIG2 (if available)

Paralogs for OLIG2 Gene

Paralogs for OLIG2 Gene

Selected SIMAP similar genes for OLIG2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLIG2: view

Variants for OLIG2 Gene

Sequence variations from dbSNP and Humsavar for OLIG2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs762178 -- 33,027,093(+) AAGTC(A/G)TCCTC reference, synonymous-codon
rs1005573 -- 33,026,408(+) TCTAT(C/T)TAGAT intron-variant
rs1059004 -- 33,028,155(+) CGACC(A/C)CCACC utr-variant-3-prime
rs1122807 -- 33,026,485(+) CCCAC(A/T)CCTAA intron-variant
rs2009130 -- 33,025,870(+) GCCCC(C/G)GCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OLIG2 Gene

Variant ID Type Subtype PubMed ID
nsv520925 CNV Loss 19592680

Relevant External Links for OLIG2 Gene

HapMap Linkage Disequilibrium report
OLIG2

Disorders for OLIG2 Gene

UniProtKB/Swiss-Prot

OLIG2_HUMAN
  • Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

(14) Novoseek inferred disease relationships for OLIG2 Gene

Disease -log(P) Hits PubMed IDs
oligodendroglial tumors 84.4 5
oligodendroglioma 81.5 15
anaplastic oligodendroglioma 73.2 5
neurocytoma central 66.7 5
astrocytoma 63.7 9

Relevant External Links for OLIG2

Genetic Association Database (GAD)
OLIG2
Human Genome Epidemiology (HuGE) Navigator
OLIG2
genes like me logo Genes that share disorders with OLIG2: view

Publications for OLIG2 Gene

  1. The t(14;21)(q11.2;q22) chromosomal translocation associated with T- cell acute lymphoblastic leukemia activates the BHLHB1 gene. (PMID: 10737801) Wang J. … Aplan P.D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  2. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PMID: 17283288) Stewart S.E. … Pauls D.L. (Arch. Gen. Psychiatry 2007) 3 23 49
  3. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PMID: 11526205) Lu Q.R. … Black P.M. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  4. OLIG2 as a specific marker of oligodendroglial tumour cells. (PMID: 11498220) Marie Y. … Hoang-Xuan K. (Lancet 2001) 3 4
  5. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. (PMID: 19477230) Sims R. … Abraham R. (Neurosci. Lett. 2009) 3 49

Products for OLIG2 Gene

  • Addgene plasmids for OLIG2

Sources for OLIG2 Gene

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