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OLIG2 Gene

protein-coding GIFtS: 59

GC21P033320

oligodendrocyte lineage transcription factor 2
(Previous name: protein kinase C binding protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PRKCBP2, BHLHB1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BHLHB1 ^², ³
OLIGO2 ^¹, ²
OTTHUMP00000067569 ^²
OTTHUMP00000067570 ^²
Oligo2 ^³
PRKCBP2 ^², ³, ⁵
RACK17 ^¹, ², ³
bHLHB1 ^³
bHLHe19 ^¹, ²

Descriptions
Class B basic helix-loop-helix protein 1 ^³
Protein kinase C-binding protein 2 ^³
Protein kinase C-binding protein RACK17 ^³
basic domain, helix-loop-helix protein, class B, 1 ^²
human protein kinase C-binding protein RACK17 ^²
oligodendrocyte lineage transcription factor 2 ^²
oligodendrocyte-specific bHLH transcription factor 2 ^²
protein kinase C binding protein 2 ^¹, ²

External Ids
HGNC: 9398¹
Entrez Gene: 10215²
UniProtKB: Q13516³
Ensembl: ENSG00000205927⁷

Search outside databases for aliases for OLIG2 gene

Previous GC identifers: GC21P030975 GC21P033318

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OLIG2:

This gene encodes a basic helix-loop-helix transcription factor which is expressed in

oligodendroglial tumors of the brain. The protein is an essential regulator of ventral

neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation

t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location

is within a region of chromosome 21 which has been suggested to play a role in learning deficits

associated with Down syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516

Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well

as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to

establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of

NKX2-2-induced V3 interneuron development (By similarity)

Gene Wiki entry for OLIG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OLIG2 gene

Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11

OLIG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21P033320: (about GC identifiers)

Start:	33,320,109 bp from pter
End:	33,323,374 bp from pter
Size:	3,266 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516 (See protein sequence)

Recommended Name: Oligodendrocyte transcription factor 2

Size: 323 amino acids; 32385 Da

Subunit: Interacts with NKX2-2 (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in

the bHLH domain could be masked in the native form and translocation to the nucleus could be

mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity)

Secondary accessions: B3KRF3 Q86X04 Q9NZ14

REFSEQ proteins: NP_005797.1

ENSEMBL proteins:

ENSP00000331040 ENSP00000371794

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Olig2)
	Human Recombinant Proteins from Abnova (OLIG2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for OLIG2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of OLIG2
	Sigma-Aldrich Antibodies for OLIG2
	R&D Systems Antibodies for OLIG2
	Antibodies from Abcam (Olig2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OLIG2)
	Novus Biologicals Antibodies for OLIG2

Assays for OLIG2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13516

ProtoNet protein and cluster: Q13516

2 Blocks protein families:

IPB000408 Regulator of chromosome condensation

IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516

Domain: The bHLH is essential for interaction with NKX2-2 (By similarity)

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLIG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLIG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005806

Applied Biosystems Silencer® siRNAs for OLIG2

Sigma-Aldrich siRNA for OLIG2

Sigma-Aldrich shRNA for OLIG2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OLIG2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005806
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005806
untagged cDNA clones in CMV expression vector (see all 2): NM_005806

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005806

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516

Function: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well

as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to

establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of

NKX2-2-induced V3 interneuron development (By similarity)

Induction: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral

hindbrain (By similarity)

9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Olig2):

behavior/neurological	growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle
nervous system	no phenotypic analysis	respiratory system	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--
GO:0042803	protein homodimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for OLIG2

5/26 Interacting proteins for OLIG2 (ENSP00000331040³) via UniProtKB, MINT, and/or STRING (see all 26 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKX2-2	ENSP00000366347³	STRING (score=.981)
SOX10	ENSP00000354130³	STRING (score=.976)
SHH	ENSP00000297261³	STRING (score=.952)
PHOX2B	ENSP00000226382³	STRING (score=.944)
SIM1	ENSP00000262901³	STRING (score=.936)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0021530	spinal cord oligodendrocyte cell fate specification	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLIG2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLIG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLIG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005806

Sigma-Aldrich siRNA for OLIG2

Sigma-Aldrich shRNA for OLIG2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005806

REFSEQ mRNAs for OLIG2 gene:

NM_005806.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005806

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005806
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005806
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005806

Additional cDNA sequence:

AF221520.1 AK091462.1 BC034681.1 BC036245.1 BC036275.1 BC047511.1 U48250.1

7 DOTS entries:

DT.85105306 DT.91651057 DT.95119479 DT.121132166 DT.121132151 DT.80101759 DT.95363865

24/88 AceView cDNA sequences (see all 88 ):

AI536683 AK091462 AI360012 BG910423 AI566559 AW510628 BG820341 NM_005806

BG820163 AI277362 BG819627 BF346679 BG910780 AI560252 AI566781 AI553817

BC047511 BI544712 BI597080 AU130620 BM548653 BF515096 BX461924 BQ067265

highest scoring ESTs for OLIG2:

U48250 AA488119 AA757419 AI088733 AI207909 AI277362 AI360012 AI363845 AI369652 AI375346

Unigene Cluster for OLIG2:

Oligodendrocyte lineage transcription factor 2

Hs.176977 [show with all ESTs]

Unigene Representative Sequence: BC036245

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000333337 ENST00000382357

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OLIG2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OLIG2

¹ / ² / ³

6 probe-sets matching OLIG2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40624_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.19	U48250	1.00	0.80	0.91	1
841_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.85	U48250	1.00	0.80	0.91	1
213825_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA757419	0.80	0.88	0.84	1
213824_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI870776	0.80	0.88	0.84	1
213825_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213824_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OLIG2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGGGATTC

SOURCE GeneReport for Unigene cluster: Hs.176977
Expression variation in blood from EXPOLDB for OLIG2
UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in
oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in
glioblastomas highly variable

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OLIG2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	OLIG2¹	--	oligodendrocyte lineage transcription factor 2	99.28(n) 100(a)	749928 XM_001172282.1 XP_001172282.1
rat (Rattus norvegicus)	Olig2¹	--	oligodendrocyte lineage transcription factor 2	88.44(n) 96.28(a)	304103 XM_221668.4 XP_221668.4
mouse (Mus musculus)	Olig2^{1, 5}	16 (63.00 cM)⁵	oligodendrocyte transcription factor 2^{1, 5}	88.13(n)¹ 96.28(a)¹	50913¹ NM_016967.2¹ NP_058663.2¹ AB038697⁵ AF232929⁵ (see all 11)
zebrafish (Danio rerio)	AF442964.1²	--	--	77.29(n)	325288 AF442964.1
African clawed frog (Xenopus laevis)	Xl.15193²	--	Xenopus laevis transcribed sequence with weak similarity more	74.04(n)	BJ037458.1

About this table Species with no ortholog for OLIG2

ENSEMBL Gene Tree for OLIG2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OLIG2 gene

BHLHE22² OLIG3² OLIG1² BHLHE23²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/31 NCBI SNPs in OLIG2 are shown (see all 31 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6517137^1,2	A,C,F,H	33322649(+)	`CACCCT/CCTTAG`	1	--	ut3¹		8		EU EA WA	836
	rs6517135^1,2	A,C,F,H	33319441(+)	`GGCCAT/CCTCCT`	1	--	ng5¹ tfbs³		2		EA	178
--	rs6517136^1,2	A,C,F,H	33322358(+)	`CTAAAA/TACTTC`	1	--	ut3¹		4		EU EA WA	412
	rs1059004^1,2	A,F	33322333(+)	`CGACCA/CCCACC`	1	--	ut3¹ ese³		1		MN	184
--	rs7278343^1,2	A	33323435(+)	`TTGGGA/GCCGGA`	1	--	ng3¹		0	--	--	--	--
--	rs2009130^1,2	A	33320048(+)	`GCCCCC/GGCCAC`	1	--	ng5¹ ese³		0	--	--	--	--
	rs9653711^1,2	A	33323819(+)	`GAGCCC/GTAGCG`	1	--	ng3¹		0	--	--	--	--
	rs11908971^1,2	C	33318150(+)	`CCCCCC/TCGCTC`	1	--	ng5¹		0	--	--	--	--
	rs9975039^1,2	C	33318462(+)	`TGAAGA/GCCAAT`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs762178^1,2	A,C,F,H	33321271(+)	`AAGTCA/GTCCTC`	1	S/S	syn¹		5		MN EU EA WA	604

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HapMap Linkage Disequilibrium images for OLIG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606386

UniProtKB/Swiss-Prot: OLIG2_HUMAN, Q13516

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute

lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA

10/14 Novoseek disease relationships for OLIG2 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligodendroglial tumors	84.11	5	16598485 (1), 15111318 (1), 12924709 (1), 17415208 (1) (see all 5)
oligodendroglioma	80.80	14	14575240 (3), 18552083 (2), 14730454 (2), 12924709 (1) (see all 10)
anaplastic oligodendroglioma	75.00	6	14575240 (3), 14730454 (1), 15198128 (1)
neurocytoma central	68.47	5	17257132 (5)
pilocytic astrocytoma	64.41	3	12924709 (1), 18312545 (1), 17442061 (1)
astrocytoma	63.55	10	18552083 (2), 15198128 (2), 16598485 (1), 17146289 (1) (see all 7)
glioblastoma	61.92	8	14575240 (2), 14730454 (1), 15198128 (1), 15164981 (1) (see all 6)
anaplastic astrocytoma	59.41	5	14575240 (2), 14730454 (1), 17917751 (1), 17415208 (1)
glioma	53.54	22	14575240 (5), 15198128 (4), 15634232 (2), 18282166 (2) (see all 7)
demyelination	52.75	2	15519240 (2)

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Human Genome Epidemiology Navigator: OLIG2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/106 PubMed articles for OLIG2 gene (see all 106 ):

Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PubMed id 11526205)^{2, 3, 4} Lu Q.R.... Black P.M. (2001)
The t(14;21)(q11.2;q22) chromosomal translocation associated with T- cell acute lymphoblastic leukemia activates the BHLHB1 gene. (PubMed id 10737801)^{1, 3, 4} Wang J.... Aplan P.D. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
OLIG2 as a specific marker of oligodendroglial tumour cells. (PubMed id 11498220)^{3, 4} Marie Y.... Hoang-Xuan K. (2001)
OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. (PubMed id 16103065)^{1, 3} Lin Y.W....Aplan P.D. (2005)
The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. (PubMed id 15198128)^{1, 3} Ligon K.L....Rowitch D.H. (2004)
A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PubMed id 17283288)^{1, 3} Stewart S.E....Pauls D.L. (2007)
Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. (PubMed id 16469306)^{1, 3} Sun T....Rowitch D.H. (2006)
Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. (PubMed id 16267213)^{1, 3} Jakovcevski I. and Zecevic N. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10215	HGNC: 9398	AceView: OLIG2	Ensembl:ENSG00000205927	euGenes: HUgn10215
ECgene: OLIG2	H-InvDB: OLIG2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for OLIG2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for OLIG2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OLIG2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OLIG2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OLIG2		Antibodies for OLIG2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OLIG2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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OLIG2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for OLIG2

Summaries
for OLIG2

Genomic Location
for OLIG2

Proteins
for OLIG2

Protein Domains/
Families
for OLIG2

Gene Function
for OLIG2

Pathways & Interactions
for OLIG2

Drugs & Compounds
for OLIG2

Transcripts
for OLIG2

Expression
for OLIG2

Orthologs
for OLIG2

Paralogs
for OLIG2

SNPs/Variants
for OLIG2

Disorders & Mutations
for OLIG2

Medical News
for OLIG2

Publications
for OLIG2

Search for OLIG2

Genome Databases showing OLIG2

Other Databases showing OLIG2

Specialized Databases showing OLIG2

Licensable Technologies
for OLIG2

Services
for OLIG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OLIG2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor OLIG2

Summariesfor OLIG2

Genomic Locationfor OLIG2

Proteinsfor OLIG2

Protein Domains/Familiesfor OLIG2

Gene Functionfor OLIG2

Pathways & Interactionsfor OLIG2

Drugs & Compoundsfor OLIG2

Transcriptsfor OLIG2

Expression for OLIG2

Orthologsfor OLIG2

Paralogsfor OLIG2

SNPs/Variantsfor OLIG2

Disorders & Mutationsfor OLIG2

Medical Newsfor OLIG2

Publicationsfor OLIG2

Search for OLIG2

Genome Databases showing OLIG2

Other Databases showing OLIG2

Specialized Databases showing OLIG2

Licensable Technologiesfor OLIG2

Servicesfor OLIG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OLIG2

Summaries
for OLIG2

Genomic Location
for OLIG2

Proteins
for OLIG2

Protein Domains/
Families
for OLIG2

Gene Function
for OLIG2

Pathways & Interactions
for OLIG2

Drugs & Compounds
for OLIG2

Transcripts
for OLIG2

Expression
for OLIG2

Orthologs
for OLIG2

Paralogs
for OLIG2

SNPs/Variants
for OLIG2

Disorders & Mutations
for OLIG2

Medical News
for OLIG2

Publications
for OLIG2

Licensable Technologies
for OLIG2

Services
for OLIG2