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Aliases for OLIG1 Gene

Aliases for OLIG1 Gene

  • Oligodendrocyte Transcription Factor 1 2 3
  • Oligodendrocyte-Specific BHLH Transcription Factor 1 2 3
  • Oligodendrocyte Lineage Transcription Factor 1 2 3
  • Class E Basic Helix-Loop-Helix Protein 21 3 4
  • Class B Basic Helix-Loop-Helix Protein 6 3 4
  • BHLHE21 3 4
  • Oligo1 3 4
  • BHLHB6 3 4
  • Basic Domain, Helix-Loop-Helix Protein, Class B, 6 3
  • Helix-Loop-Helix Protein 2
  • Basic Domain 2
  • Class B 2
  • 6 2

External Ids for OLIG1 Gene

Previous GeneCards Identifiers for OLIG1 Gene

  • GC21P031019
  • GC21P033362
  • GC21P033364
  • GC21P034442
  • GC21P019853

Summaries for OLIG1 Gene

GeneCards Summary for OLIG1 Gene

OLIG1 (Oligodendrocyte Transcription Factor 1) is a Protein Coding gene. Diseases associated with OLIG1 include astrocytoma. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is BHLHE23.

UniProtKB/Swiss-Prot for OLIG1 Gene

  • Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Gene Wiki entry for OLIG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG1 Gene

Genomics for OLIG1 Gene

Regulatory Elements for OLIG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OLIG1 Gene

Start:
33,070,144 bp from pter
End:
33,072,422 bp from pter
Size:
2,279 bases
Orientation:
Plus strand

Genomic View for OLIG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG1 Gene

Proteins for OLIG1 Gene

  • Protein details for OLIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK6-OLIG1_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 1
    Protein Accession:
    Q8TAK6
    Secondary Accessions:
    • Q7RTS0

    Protein attributes for OLIG1 Gene

    Size:
    271 amino acids
    Molecular mass:
    27905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OLIG1 Gene

Proteomics data for OLIG1 Gene at MOPED

Post-translational modifications for OLIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OLIG1 Gene

Domains for OLIG1 Gene

Gene Families for OLIG1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for OLIG1 Gene

Suggested Antigen Peptide Sequences for OLIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAK6

UniProtKB/Swiss-Prot:

OLIG1_HUMAN :
  • Q8TAK6
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with OLIG1: view

Function for OLIG1 Gene

Molecular function for OLIG1 Gene

UniProtKB/Swiss-Prot Function:
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Gene Ontology (GO) - Molecular Function for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18923419
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Phenotypes for OLIG1 Gene

genes like me logo Genes that share phenotypes with OLIG1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLIG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OLIG1 Gene

Localization for OLIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLIG1 Gene COMPARTMENTS Subcellular localization image for OLIG1 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Pathways for OLIG1 Gene

SuperPathways for OLIG1 Gene

genes like me logo Genes that share pathways with OLIG1: view

Pathways by source for OLIG1 Gene

1 BioSystems pathway for OLIG1 Gene

Gene Ontology (GO) - Biological Process for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0048663 neuron fate commitment IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Transcripts for OLIG1 Gene

mRNA/cDNA for OLIG1 Gene

Unigene Clusters for OLIG1 Gene

Oligodendrocyte transcription factor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLIG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG1 Gene

No ASD Table

Relevant External Links for OLIG1 Gene

GeneLoc Exon Structure for
OLIG1
ECgene alternative splicing isoforms for
OLIG1

Expression for OLIG1 Gene

mRNA expression in normal human tissues for OLIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLIG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.0), Brain - Substantia nigra (6.6), Brain - Amygdala (6.1), Brain - Hippocampus (5.6), Brain - Putamen (basal ganglia) (5.1), and Brain - Hypothalamus (4.7).

Protein differential expression in normal tissues for OLIG1 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OLIG1 Gene

SOURCE GeneReport for Unigene cluster for OLIG1 Gene Hs.56663

mRNA Expression by UniProt/SwissProt for OLIG1 Gene

Q8TAK6-OLIG1_HUMAN
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
genes like me logo Genes that share expressions with OLIG1: view

Expression partners for OLIG1 Gene

In Situ Assay Products

Orthologs for OLIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLIG1 35
  • 89.06 (n)
  • 89.31 (a)
OLIG1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG1 35
  • 92.37 (n)
  • 90.77 (a)
OLIG1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olig1 35
  • 84.56 (n)
  • 87.26 (a)
Olig1 16
Olig1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLIG1 35
  • 98.89 (n)
  • 98.15 (a)
OLIG1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig1 35
  • 85.51 (n)
  • 88.85 (a)
oppossum
(Monodelphis domestica)
Mammalia OLIG1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olig1 35
  • 61.24 (n)
  • 66.27 (a)
zebrafish
(Danio rerio)
Actinopterygii olig1 35
  • 59.65 (n)
  • 59.21 (a)
olig1 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-16 36
  • 28 (a)
OneToMany
Species with no ortholog for OLIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG1 Gene

ENSEMBL:
Gene Tree for OLIG1 (if available)
TreeFam:
Gene Tree for OLIG1 (if available)

Paralogs for OLIG1 Gene

Paralogs for OLIG1 Gene

genes like me logo Genes that share paralogs with OLIG1: view

Variants for OLIG1 Gene

Sequence variations from dbSNP and Humsavar for OLIG1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs6517140 -- 33,068,544(+) TCCAG(C/G)ACACA upstream-variant-2KB
rs9983755 -- 33,068,363(+) GGCCC(C/G)CAGCA upstream-variant-2KB
rs28396271 -- 33,069,059(+) TTCTA(A/G)TAAGA upstream-variant-2KB
rs75244142 -- 33,069,236(+) GCTAC(C/T)TGTCA upstream-variant-2KB
rs75250616 -- 33,068,346(+) TCTCT(C/G)TCCCA upstream-variant-2KB

Relevant External Links for OLIG1 Gene

HapMap Linkage Disequilibrium report
OLIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OLIG1 Gene

Disorders for OLIG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OLIG1 Gene in MalaCards »

(1) Diseases for OLIG1 Gene including...

(10) Novoseek inferred disease relationships for OLIG1 Gene

Disease -log(P) Hits PubMed IDs
oligodendroglial tumors 79.5 2
oligodendroglioma 76 4
anaplastic oligodendroglioma 67.8 2
anaplastic astrocytoma 60.7 2
astrocytoma 53 1

Relevant External Links for OLIG1

Genetic Association Database (GAD)
OLIG1
Human Genome Epidemiology (HuGE) Navigator
OLIG1
genes like me logo Genes that share disorders with OLIG1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for OLIG1 Gene

Publications for OLIG1 Gene

  1. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PMID: 17283288) Stewart S.E. … Pauls D.L. (Arch. Gen. Psychiatry 2007) 3 23 48
  2. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PMID: 11526205) Lu Q.R. … Black P.M. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  3. Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. (PMID: 17171653) Ruf N. … Uhlenberg B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  4. Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. (PMID: 17388669) Brena R.M. … Plass C. (PLoS Med. 2007) 3 23
  5. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. (PMID: 10719889) Zhou Q. … Anderson D.J. (Neuron 2000) 3 4

Products for OLIG1 Gene

  • Addgene plasmids for OLIG1

Sources for OLIG1 Gene

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