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Aliases for OLIG1 Gene

Aliases for OLIG1 Gene

  • Oligodendrocyte Transcription Factor 1 2 3 5
  • Oligodendrocyte-Specific BHLH Transcription Factor 1 2 3
  • Oligodendrocyte Lineage Transcription Factor 1 2 3
  • Class E Basic Helix-Loop-Helix Protein 21 3 4
  • Class B Basic Helix-Loop-Helix Protein 6 3 4
  • BHLHE21 3 4
  • Oligo1 3 4
  • BHLHB6 3 4
  • Basic Domain, Helix-Loop-Helix Protein, Class B, 6 3
  • Helix-Loop-Helix Protein 2
  • Basic Domain 2
  • Class B 2
  • 6 2

External Ids for OLIG1 Gene

Previous GeneCards Identifiers for OLIG1 Gene

  • GC21P031019
  • GC21P033362
  • GC21P033364
  • GC21P034442
  • GC21P019853

Summaries for OLIG1 Gene

GeneCards Summary for OLIG1 Gene

OLIG1 (Oligodendrocyte Transcription Factor 1) is a Protein Coding gene. Diseases associated with OLIG1 include Oligodendroglioma. Among its related pathways are Neural Crest Differentiation and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is BHLHE23.

UniProtKB/Swiss-Prot for OLIG1 Gene

  • Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Gene Wiki entry for OLIG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG1 Gene

Genomics for OLIG1 Gene

Regulatory Elements for OLIG1 Gene

Enhancers for OLIG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OLIG1 on UCSC Golden Path with GeneCards custom track

Promoters for OLIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OLIG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OLIG1 Gene

Chromosome:
21
Start:
33,070,144 bp from pter
End:
33,072,422 bp from pter
Size:
2,279 bases
Orientation:
Plus strand

Genomic View for OLIG1 Gene

Genes around OLIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG1 Gene

Proteins for OLIG1 Gene

  • Protein details for OLIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK6-OLIG1_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 1
    Protein Accession:
    Q8TAK6
    Secondary Accessions:
    • Q7RTS0

    Protein attributes for OLIG1 Gene

    Size:
    271 amino acids
    Molecular mass:
    27905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OLIG1 Gene

Proteomics data for OLIG1 Gene at MOPED

Post-translational modifications for OLIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OLIG1 Gene

Domains & Families for OLIG1 Gene

Gene Families for OLIG1 Gene

Protein Domains for OLIG1 Gene

Suggested Antigen Peptide Sequences for OLIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAK6

UniProtKB/Swiss-Prot:

OLIG1_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with OLIG1: view

Function for OLIG1 Gene

Molecular function for OLIG1 Gene

UniProtKB/Swiss-Prot Function:
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Gene Ontology (GO) - Molecular Function for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Phenotypes for OLIG1 Gene

genes like me logo Genes that share phenotypes with OLIG1: view

Animal Models for OLIG1 Gene

MGI Knock Outs for OLIG1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OLIG1 Gene

Localization for OLIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLIG1 Gene COMPARTMENTS Subcellular localization image for OLIG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for OLIG1 Gene

Pathways & Interactions for OLIG1 Gene

genes like me logo Genes that share pathways with OLIG1: view

Pathways by source for OLIG1 Gene

1 BioSystems pathway for OLIG1 Gene

SIGNOR curated interactions for OLIG1 Gene

Activates:

Gene Ontology (GO) - Biological Process for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048709 oligodendrocyte differentiation IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Drugs & Compounds for OLIG1 Gene

No Compound Related Data Available

Transcripts for OLIG1 Gene

mRNA/cDNA for OLIG1 Gene

Unigene Clusters for OLIG1 Gene

Oligodendrocyte transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG1 Gene

No ASD Table

Relevant External Links for OLIG1 Gene

GeneLoc Exon Structure for
OLIG1
ECgene alternative splicing isoforms for
OLIG1

Expression for OLIG1 Gene

mRNA expression in normal human tissues for OLIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLIG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Brain - Substantia nigra (x6.6), Brain - Amygdala (x6.1), Brain - Hippocampus (x5.6), Brain - Putamen (basal ganglia) (x5.1), and Brain - Hypothalamus (x4.7).

Protein differential expression in normal tissues from HIPED for OLIG1 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLIG1 Gene



SOURCE GeneReport for Unigene cluster for OLIG1 Gene Hs.56663

mRNA Expression by UniProt/SwissProt for OLIG1 Gene

Q8TAK6-OLIG1_HUMAN
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
genes like me logo Genes that share expression patterns with OLIG1: view

Protein tissue co-expression partners for OLIG1 Gene

- Elite partner

Primer Products

Orthologs for OLIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLIG1 35
  • 89.06 (n)
  • 89.31 (a)
OLIG1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG1 35
  • 92.37 (n)
  • 90.77 (a)
OLIG1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olig1 35
  • 84.56 (n)
  • 87.26 (a)
Olig1 16
Olig1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLIG1 35
  • 98.89 (n)
  • 98.15 (a)
OLIG1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig1 35
  • 85.51 (n)
  • 88.85 (a)
oppossum
(Monodelphis domestica)
Mammalia OLIG1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olig1 35
  • 61.24 (n)
  • 66.27 (a)
zebrafish
(Danio rerio)
Actinopterygii olig1 35
  • 59.65 (n)
  • 59.21 (a)
olig1 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-16 36
  • 28 (a)
OneToMany
Species with no ortholog for OLIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG1 Gene

ENSEMBL:
Gene Tree for OLIG1 (if available)
TreeFam:
Gene Tree for OLIG1 (if available)

Paralogs for OLIG1 Gene

Paralogs for OLIG1 Gene

genes like me logo Genes that share paralogs with OLIG1: view

Variants for OLIG1 Gene

Sequence variations from dbSNP and Humsavar for OLIG1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs6517140 -- 33,068,544(+) TCCAG(C/G)ACACA upstream-variant-2KB
rs9983755 -- 33,068,363(+) GGCCC(A/C/G)CAGCA upstream-variant-2KB
rs762180 -- 33,071,475(+) CACGC(C/G)GGCTC utr-variant-3-prime
rs7278735 -- 33,072,776(+) ACATC(C/T)TTCCA downstream-variant-500B
rs10604048 -- 33,069,459(+) ATGCT(-/ACA)ACATG upstream-variant-2KB

Variation tolerance for OLIG1 Gene

Gene Damage Index Score: 2.04; 37.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OLIG1 Gene

Disorders for OLIG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OLIG1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search OLIG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OLIG1

Genetic Association Database (GAD)
OLIG1
Human Genome Epidemiology (HuGE) Navigator
OLIG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLIG1
genes like me logo Genes that share disorders with OLIG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLIG1 Gene

Publications for OLIG1 Gene

  1. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PMID: 11526205) Lu Q.R. … Black P.M. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 67
  2. An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling. (PMID: 18923419) Ikushima H. … Miyazono K. (EMBO J. 2008) 3 23
  3. Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. (PMID: 17171653) Ruf N. … Uhlenberg B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  4. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PMID: 17283288) Stewart S.E. … Pauls D.L. (Arch. Gen. Psychiatry 2007) 3 23
  5. Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. (PMID: 17388669) Brena R.M. … Plass C. (PLoS Med. 2007) 3 23

Products for OLIG1 Gene

Sources for OLIG1 Gene

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