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OLIG1 Gene

protein-coding   GIFtS: 54

GC21P033364
oligodendrocyte transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BHLHB6 1, 2
BHLHE21 2
Oligo1 3
bHLHe21 1
Descriptions
basic domain, helix-loop-helix protein, class B, 6 2
oligodendrocyte lineage transcription factor 1 2
oligodendrocyte transcription factor 1 2
oligodendrocyte-specific bHLH transcription factor 1 2
External Ids
HGNC: 169831
Entrez Gene: 1164482
UniProtKB: Q8TAK63
Ensembl: ENSG000001842217
Search outside databases for aliases for OLIG1 gene

Previous GC identifers: GC21P031019 GC21P033362

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
Function: Promotes formation and maturation of oligodendrocytes, especially within the brain.
Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity)

Gene Wiki entry for OLIG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OLIG1 gene  

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

OLIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P033364:     (about GC identifiers)

Start:
33,364,320 bp from pter
End:
33,366,596 bp from pter
Size:
2,277 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000021.7  NT_011512.10  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6 (See protein sequence)
Recommended Name: Oligodendrocyte transcription factor 1  
Size: 271 amino acids; 27905 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q7RTS0

REFSEQ proteins: NP_620450.2  

ENSEMBL proteins: 
ENSP00000331066 ENSP00000371785 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Olig1)
Human Recombinant Proteins from Abnova (OLIG1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

Antibodies for OLIG1: 
Invitrogen Antibodies for OLIG1
Millipore Mono- and Polyclonal Antibodies for the study of OLIG1
Sigma-Aldrich Antibodies for OLIG1
R&D Systems Antibodies for OLIG1
Antibodies from Abcam (Olig1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OLIG1)
Novus Biologicals Antibodies for OLIG1

Assays for OLIG1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR001092 HLH_basic
 IPR011598 HLH_DNA_bd


   GeneDecks  OLIG1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8TAK6

ProtoNet protein and cluster: Q8TAK6

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLIG1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLIG1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138983

              Applied Biosystems Silencer® siRNAs for OLIG1

              Sigma-Aldrich siRNA for OLIG1  
                     Sigma-Aldrich shRNA for OLIG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for OLIG1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138983
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138983
                                 untagged cDNA clones in CMV expression vector (see all 2): BC033290 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: BC033290

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
Function: Promotes formation and maturation of oligodendrocytes, especially within the brain.
Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity)
Induction: By SHH (By similarity)

3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Olig1):

growth/sizelethality-prenatal/perinatalnervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0005515 protein binding IEA--
GO:0030528 transcription regulator activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  OLIG1 


5/8 Interacting proteins for OLIG1 (ENSP000003717853) via UniProtKB, MINT, and/or STRING (see all 8 )
InteractantInteraction Details
GeneCardExternal ID(s)
SOX10ENSP000003541303STRING (score=.95)
SMAD2ENSP000002621603STRING (score=.859)
HES5ENSP000003677143STRING (score=.792)
MBPENSP000003482733STRING (score=.77)
NKX2-2ENSP000003663473STRING (score=.746)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007275 multicellular organismal development IEA--
GO:0048663 neuron fate commitment IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLIG1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OLIG1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OLIG1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138983

              Sigma-Aldrich siRNA for OLIG1  
                     Sigma-Aldrich shRNA for OLIG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_138983  

REFSEQ mRNAs for OLIG1 gene: 

NM_138983.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_138983  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138983
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138983
                                 untagged cDNA clones in CMV expression vector (see all 2): BC033290 

Additional cDNA sequence: 

AB209791.1 AL355743.1 AL834450.1 BC011252.1 BC026989.1 BC033290.1 

2 DOTS entries:

DT.209886  DT.95172090 

24/73 AceView cDNA sequences (see all 73 ):

AI199664 NM_138983 AI479913 AI566858 AW026386 AW298788 BC026989 AW071904 
BM672942 BK000278 AI359174 BC011252 AW292168 AW614560 AI272180 AW292625 
BG818170 BG820894 BF347799 CA438546 BF345621 BG056808 BG819935 AL355743 

highest scoring ESTs for OLIG1:

R56745 AI214065 AI214085 BF345621 BG820604 BG911932 BG912343 BG913267 BG913961 BG914200 

Unigene Cluster for OLIG1:

Oligodendrocyte transcription factor 1
Hs.56663  [show with all ESTs]
Unigene Representative Sequence: BC033290


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000333063  ENST00000382348  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OLIG1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OLIG1

1 / 2 / 3

4 probe-sets matching OLIG1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
79731_at2, 3 U95-D 1 1.00 1.00 0.99 0.85 R56745 1.00 1.00 1.00 1

46126_at2, 3 U95-B 1 1.00 1.00 0.98 1.16 AI498592 1.00 0.77 0.89 1

228170_at2, 3 U133-B 1 1.00 1.00 -- -- AL355743 0.60 0.83 0.73 1

228170_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  OLIG1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACGCCCTGC

SOURCE GeneReport for Unigene cluster: Hs.56663

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in
oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in
glioblastomas is highly variable

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OLIG1 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OLIG11   -- oligodendrocyte transcription factor 1 92.81(n)
92.94(a)
487736  XM_847119.1  XP_852212.1 
chimpanzee
(Pan troglodytes)
OLIG11   -- oligodendrocyte transcription factor 1 99.35(n)
99.22(a)
458513  XM_530336.2  XP_530336.2 
cow
(Bos taurus)
OLIG11   -- oligodendrocyte transcription factor 1 89.84(n)
92.28(a)
539307  XM_586373.3  XP_586373.3 
rat
(Rattus norvegicus)
Olig11   -- oligodendrocyte transcription factor 1 86.97(n)
92.59(a)
60394  NM_021770.2  NP_068538.1 
mouse
(Mus musculus)
Olig11, 5 165
oligodendrocyte transcription factor 11, 5 86.09(n)1
91.74(a)1
509141  NM_016968.41  NP_058664.21 
 AB0386965  AF2329285  (see all 14)
About this table        Species with no ortholog for OLIG1

ENSEMBL Gene Tree for OLIG1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OLIG1 gene
BHLHE222  OLIG32  BHLHE232  OLIG22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/20 NCBI SNPs in OLIG1 are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 20)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 21 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs65171401,2
A,C,F,H33362720(+) TCCAGG/CACACA 1 -- ng514Minor allele frequency- C:0.02EU EA WA 416
rs72787351,2
A,C,F,H33366952(+) ACATCC/TTTCCA 1 -- ng314Minor allele frequency- T:0.24EU EA WA 416
--
rs7621801,2
F33365651(+) CACGCC/GGGCTC 1 -- ut31 ese31Minor allele frequency- G:0.04MN 184
rs284980051,2
--33363719(+) TATGAA/GGGACC 1 -- ng51 tfbs30--------
--
rs99827591,2
--33366345(+) CCCGCA/GGGTCT 1 -- ut31 ese30--------
--
rs622141741,2
--33366259(+) CTGCTC/TGGCGG 1 -- ut310--------
--
rs115546011,2
--33366507(-) TAAATG/TCGGCT 1 -- ut31 ese30--------
--
rs358834081,2
--33363480(+) AAAAA-/ACATGA 1 -- ng510--------
--
rs106040481,2
--33363632(+) atgct-/ACAacatg 1 -- ng510--------
rs115546001,2
--33366007(+) TTTTCA/GCTCTT 1 -- ut310--------
About this table

HapMap Linkage Disequilibrium images for OLIG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606385

9 Novoseek disease relationships for OLIG1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
oligodendroglial tumors 81.62 2 12924709 (1), 15164981 (1)
oligodendroglioma 74.86 5 14989603 (2), 14730454 (1), 15164981 (1)
anaplastic oligodendroglioma 70.38 2 14730454 (1), 14575240 (1)
anaplastic astrocytoma 63.06 2 14730454 (1), 14575240 (1)
astrocytoma 55.65 1 14730454 (1)
glioblastoma 46.46 3 14730454 (1), 14575240 (1), 15164981 (1)
brain tumors 38.96 4 14989603 (2), 12924709 (1)
glioma 34.29 3 14575240 (2), 14730454 (1)
tumors 6.82 1 12924709 (1)
About this table

Human Genome Epidemiology Navigator: OLIG1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/33 PubMed articles for OLIG1 gene (see all 33 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 116448 HGNC: 16983 AceView: OLIG1 Ensembl:ENSG00000184221 euGenes: HUgn116448
ECgene: OLIG1 H-InvDB: OLIG1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OLIG1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OLIG1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OLIG1 Antibodies for OLIG1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OLIG1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for OLIG1

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