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Aliases & Descriptions for OLIG1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BHLHB6 1, 2 | | BHLHE21 2 | | Oligo1 3 | | bHLHe21 1 |
| | | Descriptions |
|---|
| basic domain, helix-loop-helix protein, class B, 6 2 | | oligodendrocyte lineage transcription factor 1 2 | | oligodendrocyte transcription factor 1 2 | | oligodendrocyte-specific bHLH transcription factor 1 2 |
|
| | Search outside databases for aliases for OLIG1 genePrevious GC identifers: GC21P031019 GC21P033362 |
Summaries for OLIG1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6Function: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity)Gene Wiki entry for OLIG1 |
Genomic Location for OLIG1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OLIG1 gene 
Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11OLIG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P033364:
(about GC identifiers)
Start:
|
33,364,320 bp from pter |
End:
|
33,366,596 bp from pter |
Size:
|
2,277 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000021.7 NT_011512.10
| Proteins for OLIG1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6 (See
protein sequence)Recommended Name: Oligodendrocyte transcription factor 1 Size: 271 amino acids; 27905 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q7RTS0REFSEQ proteins: NP_620450.2
ENSEMBL proteins: ENSP00000331066 ENSP00000371785
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for OLIG1:  | Invitrogen Antibodies for OLIG1 |  | Millipore Mono- and Polyclonal Antibodies for the study of OLIG1 |  | Sigma-Aldrich Antibodies for OLIG1 |  | R&D Systems Antibodies for OLIG1 |  | Antibodies from Abcam (Olig1), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (OLIG1) |  | Novus Biologicals Antibodies for OLIG1 |
Assays for OLIG1: | Protein
Domains/ Families for OLIG1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TAK6
ProtoNet protein and cluster: Q8TAK6 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6Similarity: Contains 1 basic helix-loop-helix (bHLH) domain | Gene Function for OLIG1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138983
Applied Biosystems Silencer® siRNAs for OLIG1
Sigma-Aldrich siRNA for OLIG1  Sigma-Aldrich shRNA for OLIG1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138983                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138983                                  untagged cDNA clones in CMV expression vector (see all 2): BC033290 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC033290
UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6Function: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity)Induction: By SHH (By similarity)3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Olig1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OLIG1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for OLIG1 
5/8 Interacting proteins for OLIG1 (ENSP000003717853) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0048663 | neuron fate commitment |
IEA | -- | About this table
|
Drugs & Compounds for OLIG1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OLIG1
|
Transcripts for OLIG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138983
Sigma-Aldrich siRNA for OLIG1  Sigma-Aldrich shRNA for OLIG1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_138983 REFSEQ mRNAs for OLIG1 gene: NM_138983.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138983               OriGene GFP tagged cDNA clone in CMV expression vector: NM_138983                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138983                                  untagged cDNA clones in CMV expression vector (see all 2): BC033290  Additional cDNA sequence: AB209791.1 AL355743.1 AL834450.1 BC011252.1 BC026989.1 BC033290.1 2 DOTS entries: DT.209886 DT.95172090 24/73 AceView cDNA sequences (see all 73
):AI199664 NM_138983 AI479913 AI566858 AW026386 AW298788 BC026989 AW071904 BM672942 BK000278 AI359174 BC011252 AW292168 AW614560 AI272180 AW292625 BG818170 BG820894 BF347799 CA438546 BF345621 BG056808 BG819935 AL355743
highest scoring ESTs for OLIG1:R56745 AI214065 AI214085 BF345621 BG820604 BG911932 BG912343 BG913267 BG913961 BG914200 Unigene Cluster for OLIG1: Oligodendrocyte transcription factor 1 Hs.56663 [show with all ESTs]Unigene Representative Sequence: BC033290
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000333063
ENST00000382348
|
Expression for OLIG1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OLIG1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OLIG1
1 / 2 / 3 4 probe-sets matching OLIG1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GACGCCCTGC
SOURCE GeneReport for Unigene cluster: Hs.56663 UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable |
Orthologs for OLIG1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OLIG1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for OLIG1
ENSEMBL Gene Tree for OLIG1 | Paralogs for OLIG1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OLIG1 gene
- BHLHE222 OLIG32 BHLHE232 OLIG22
|
SNPs/Variants for OLIG1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OLIG1 (up to first 250kb)
|
Disorders & Mutations for OLIG1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606385
9 Novoseek disease relationships for OLIG1 gene
About this table
Human Genome Epidemiology Navigator: OLIG1 (1 document)
|
Medical News for OLIG1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OLIG1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/33 PubMed articles for OLIG1 gene (see all 33
):- Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PubMed id 11526205)2, 3, 4 Lu Q.R.... Black P.M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)3, 4 McLellan A.S.... Kealey T. (2002)
- Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. (PubMed id 10719889)3, 4 Zhou Q.... Anderson D.J. (2000)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)3, 4 Hattori M....Yaspo M.L. (2000)
- Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. (PubMed id 16267213)1, 3 Jakovcevski I. and Zecevic N. (2005)
- Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. (PubMed id 17171653)1, 3 Ruf N....Uhlenberg B. (2007)
- Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. (PubMed id 11091082)1, 3 Takebayashi H....Nabeshima Y. (2000)
- Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. (PubMed id 17388669)1, 3 Brena R.M....Plass C. (2007)
- A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PubMed id 17283288)1, 3 Stewart S.E....Pauls D.L. (2007)
|
Search for OLIG1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OLIG1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OLIG1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OLIG1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OLIG1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OLIG1:

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Incremental update: 13 Oct 2009
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