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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLIG1 Gene

protein-coding   GIFtS: 54
GCID: GC21P034442

oligodendrocyte transcription factor 1

 Explore 17 diseases affiliated with
OLIG1 via our new
 Human Malady Compendium 
Biological research products
for OLIG1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Oligodendrocyte Transcription Factor 11 2     Basic Domain, Helix-Loop-Helix Protein, Class B, 62
BHLHB61 2 3     Oligo13
BHLHe211     Oligodendrocyte Lineage Transcription Factor 12
Class B Basic Helix-Loop-Helix Protein 62 3     Oligodendrocyte-Specific BHLH Transcription Factor 12
Class E Basic Helix-Loop-Helix Protein 212 3     Oligo13
BHLHE212 3     BHLHb61

External Ids:    HGNC: 169831   Entrez Gene: 1164482   Ensembl: ENSG000001842217   OMIM: 6063855   UniProtKB: Q8TAK63   

Export aliases for OLIG1 gene to outside databases

Previous GC identifers: GC21P031019 GC21P033362 GC21P033364 GC21P019853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
Function: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to
establish the pMN domain of the embryonic neural tube (By similarity)

Gene Wiki entry for OLIG1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLIG1 gene promoter:
         AP-1   NRSF form 1   MyoD   NRSF form 2   Arnt   Ik-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLIG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OLIG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLIG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

OLIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLIG1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P034442:  view genomic region     (about GC identifiers)

Start:
34,442,450 bp from pter      End:
34,444,728 bp from pter
Size:
2,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6 (See protein sequence)
Recommended Name: Oligodendrocyte transcription factor 1  
Size: 271 amino acids; 27905 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH26989.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=DAA01058.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7RTS0

Explore the universe of human proteins at neXtProt for OLIG1: NX_Q8TAK6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAK6

  • OLIG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_620450.2  
    ENSEMBL proteins: 
     ENSP00000371785   ENSP00000414840   ENSP00000331066  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OLIG1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    OLIG1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OLIG1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q8TAK6

    ProtoNet protein and cluster: Q8TAK6

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
    Function: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to
    establish the pMN domain of the embryonic neural tube (By similarity)

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    hsa-miR-582-3p hsa-miR-3168 hsa-miR-4271 hsa-miR-7-2* hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidOLIG1 3' UTR sequence
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--


    OLIG1 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Olig1):
     growth/size  mortality/aging  nervous system 

    OLIG1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neural Crest Differentiation
    Neural Crest Differentiation1.00


    1 BioSystems Pathway for OLIG1 
        Neural Crest Differentiation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OLIG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/14 Interacting proteins for OLIG1 (Q8TAK62, 3 ENSP000003310664) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-7295493 MINT-7295480 I2D: score=1 STRING: ENSP00000262160
    CCNDBP1O952732, 3, ENSP000003002134MINT-8396226 I2D: score=1 STRING: ENSP00000300213
    ID4P479283, ENSP000003679724I2D: score=1 STRING: ENSP00000367972
    ID2Q023633, ENSP000002340914I2D: score=1 STRING: ENSP00000234091
    BRCA1P383983I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0048663neuron fate commitment IEA--


    OLIG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLIG1
    Search CenterWatch for drugs/clinical trials and news about OLIG1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OLIG1 gene: 
    NM_138983.2  

    Unigene Cluster for OLIG1:

    Oligodendrocyte transcription factor 1
    Hs.56663  [show with all ESTs]
    Unigene Representative Sequence: BC033290
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382348(uc002yqz.3) ENST00000426947 ENST00000498799 ENST00000333063


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    Additional cDNA sequence: 

    AB209791.1 AL355743.1 AL834450.1 BC011252.1 BC026989.1 BC033290.1 

    2 DOTS entries:

    DT.209886  DT.95172090 

    24/73 AceView cDNA sequences (see all 73):

    AI199664 BK000278 BC011252 AI272180 AW071904 BM672942 AW026386 AI479913 
    AI566858 AW614560 BC026989 AW292168 NM_138983 AW298788 AI359174 BG913499 
    AI214085 AW292625 BF345260 AW292622 BF345621 AW131811 BG820894 Z38150 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLIG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACGCCCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    OLIG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OLIG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLIG1

    SOURCE GeneReport for Unigene cluster: Hs.56663

    UniProtKB/Swiss-Prot: OLIG1_HUMAN, Q8TAK6
    Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while
    expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLIG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OLIG1 gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii olig11 oligodendrocyte lineage transcription factor 1 57.79(n)
    57.4(a)
      100001484  NM_001020796.1  NP_001018632.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-166
    Helix Loop Helix family member (hlh-16)
    27(a)
    1 → many
    I(8767013-8768022)


    ENSEMBL Gene Tree for OLIG1 (if available)
    TreeFam Gene Tree for OLIG1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLIG1 gene
    OLIG32  BHLHE222  BHLHE232  OLIG22  

    OLIG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/56 NCBI SNPs in OLIG1 are shown (see all 56    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752506161,2
    F,--34440652(+) TCTCTC/GTCCCA 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs99837551,2
    C,F,--34440669(+) GGCCCC/GCAGCA 1 -- us2k19Minor allele frequency- G:0.28NA WA EA 370
    rs1142975261,2
    F,--34440678(+) CACCAC/TGTCCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1829346061,2
    --34440712(+) GGCAGA/GAGATC 1 -- us2k10--------
    rs1403562471,2
    --34440771(+) TTAGAA/GCATTG 1 -- us2k10--------
    rs65171401,2
    C,F,A,H,--34440850(+) TCCAGG/CACACA 1 -- us2k15Minor allele frequency- C:0.04NS EA WA 534
    rs1499441751,2
    --34440877(+) CTGTGA/CTAGGC 1 -- us2k10--------
    rs799502411,2
    --34440885(+) GGCTTC/TAGGAA 1 -- us2k10--------
    rs1883825671,2
    --34441056(+) GCAAGG/TTTGGA 1 -- us2k10--------
    rs1918314301,2
    --34441232(+) AAGTTA/GTAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OLIG1 (34442450 - 34444728 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OLIG1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OLIG1 for disorders           About GeneDecksing

    OMIM gene information: 606385    OMIM disorders: --

    17 diseases for OLIG1:    About MalaCards
    spinal cord injury    obsessive-compulsive disorder    anaplastic oligodendroglioma    anaplastic astrocytoma
    oligodendroglioma    pilocytic astrocytoma    brain injury    macular degeneration
    astrocytoma    leukodystrophy    cerebral lymphoma    multiple sclerosis
    glioblastoma    lung cancer    ataxia    cerebritis
    neuronitis

    10 Novoseek disease relationships for OLIG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligodendroglial tumors 79.5 2 12924709 (1), 15164981 (1)
    oligodendroglioma 76 5 14989603 (2), 14730454 (1), 15164981 (1)
    anaplastic oligodendroglioma 67.8 2 14730454 (1), 14575240 (1)
    anaplastic astrocytoma 60.7 2 14730454 (1), 14575240 (1)
    astrocytoma 53 1 14730454 (1)
    demyelination 52.6 1 19318112 (1)
    brain tumors 43.5 4 14989603 (2), 12924709 (1)
    glioblastoma 42.7 3 14730454 (1), 14575240 (1), 15164981 (1)
    glioma 30.6 3 14575240 (2), 14730454 (1)
    tumors 11.3 1 12924709 (1)

    Human Genome Epidemiology (HuGE) Navigator: OLIG1 (1 document)

    Export disorders for OLIG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLIG1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with OLIG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PubMed id 11526205)1, 2, 3 Lu Q.R.... Black P.M. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2 McLellan A.S.... Kealey T. (2002)
    4. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. (PubMed id 10719889)1, 2 Zhou Q.... Anderson D.J. (2000)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. (PubMed id 16267213)1, 9 Jakovcevski I. and Zecevic N. (2005)
    7. Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. (PubMed id 17171653)1, 9 Ruf N....Uhlenberg B. (2007)
    8. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. (PubMed id 11091082)1, 9 Takebayashi H....Nabeshima Y. (2000)
    9. Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. (PubMed id 17388669)1, 9 Brena R.M....Plass C. (2007)
    10. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PubMed id 17283288)1, 9 Stewart S.E....Pauls D.L. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116448 HGNC: 16983 AceView: OLIG1 Ensembl:ENSG00000184221 euGenes: HUgn116448
    ECgene: OLIG1 H-InvDB: OLIG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for OLIG1 Pharmacogenomics, SNPs, Pathways

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