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Aliases for OLFML3 Gene

Aliases for OLFML3 Gene

  • Olfactomedin-Like 3 2 3
  • HNOEL-Iso 3 4
  • OLF44 3 6
  • Olfactomedin-Like Protein 3 3
  • HOLF44 4

External Ids for OLFML3 Gene

Summaries for OLFML3 Gene

GeneCards Summary for OLFML3 Gene

OLFML3 (Olfactomedin-Like 3) is a Protein Coding gene. An important paralog of this gene is GLDN.

UniProtKB/Swiss-Prot for OLFML3 Gene

  • Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Gene Wiki entry for OLFML3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML3 Gene

Genomics for OLFML3 Gene

Genomic Location for OLFML3 Gene

Start:
113,979,391 bp from pter
End:
113,982,254 bp from pter
Size:
2,864 bases
Orientation:
Plus strand

Genomic View for OLFML3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML3 Gene

Regulatory Elements for OLFML3 Gene

Proteins for OLFML3 Gene

  • Protein details for OLFML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRN5-OLFL3_HUMAN
    Recommended name:
    Olfactomedin-like protein 3
    Protein Accession:
    Q9NRN5
    Secondary Accessions:
    • Q53FR1
    • Q53HV9
    • Q5SQL6
    • Q69AX9
    • Q8NBJ2

    Protein attributes for OLFML3 Gene

    Size:
    406 amino acids
    Molecular mass:
    46010 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OLFML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML3 Gene

Proteomics data for OLFML3 Gene at MOPED

Post-translational modifications for OLFML3 Gene

  • Glycosylation at Asn177 and Asn248

Other Protein References for OLFML3 Gene

No data available for DME Specific Peptides for OLFML3 Gene

Domains for OLFML3 Gene

Protein Domains for OLFML3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

OLFL3_HUMAN
Domain:
  • Contains 1 olfactomedin-like domain.:
    • Q9NRN5
Family:
  • Belongs to the OLFML3 family.:
    • Q9NRN5
genes like me logo Genes that share domains with OLFML3: view

No data available for Gene Families for OLFML3 Gene

Function for OLFML3 Gene

Molecular function for OLFML3 Gene

UniProtKB/Swiss-Prot Function: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Gene Ontology (GO) - Molecular Function for OLFML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OLFML3: view

Phenotypes for OLFML3 Gene

MGI mutant phenotypes for OLFML3:
inferred from 1 alleles
GenomeRNAi human phenotypes for OLFML3:
genes like me logo Genes that share phenotypes with OLFML3: view

miRNA for OLFML3 Gene

miRTarBase miRNAs that target OLFML3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OLFML3 Gene

Localization for OLFML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML3 Gene COMPARTMENTS Subcellular localization image for OLFML3 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OLFML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031982 vesicle IDA 24769233
genes like me logo Genes that share ontologies with OLFML3: view

Pathways for OLFML3 Gene

SuperPathways for OLFML3 Gene

No Data Available

Interacting Proteins for OLFML3 Gene

Gene Ontology (GO) - Biological Process for OLFML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with OLFML3: view

No data available for Pathways by source for OLFML3 Gene

Transcripts for OLFML3 Gene

Unigene Clusters for OLFML3 Gene

Olfactomedin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6: - -

Relevant External Links for OLFML3 Gene

GeneLoc Exon Structure for
OLFML3
ECgene alternative splicing isoforms for
OLFML3

Expression for OLFML3 Gene

mRNA expression in normal human tissues for OLFML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLFML3 Gene

SOURCE GeneReport for Unigene cluster for OLFML3 Gene Hs.9315

mRNA Expression by UniProt/SwissProt for OLFML3 Gene

Q9NRN5-OLFL3_HUMAN
Tissue specificity: Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.
genes like me logo Genes that share expressions with OLFML3: view

Orthologs for OLFML3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML3 36
  • 99.75 (n)
  • 100 (a)
OLFML3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLFML3 36
  • 91.3 (n)
  • 97.04 (a)
OLFML3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML3 36
  • 89.24 (n)
  • 96.31 (a)
OLFML3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml3 36
  • 89 (n)
  • 94.09 (a)
Olfml3 16
Olfml3 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML3 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml3 36
  • 89.33 (n)
  • 94.83 (a)
chicken
(Gallus gallus)
Aves OLFML3 36
  • 67.01 (n)
  • 65.22 (a)
OLFML3 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML3 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml3 36
  • 63.87 (n)
  • 58.65 (a)
zebrafish
(Danio rerio)
Actinopterygii olfml3a 37
  • 44 (a)
OneToMany
olfml3b 36
  • 59.67 (n)
  • 51.81 (a)
olfml3b 37
  • 51 (a)
OneToMany
wufb02c05 36
Species with no ortholog for OLFML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML3 Gene

ENSEMBL:
Gene Tree for OLFML3 (if available)
TreeFam:
Gene Tree for OLFML3 (if available)

Paralogs for OLFML3 Gene

Paralogs for OLFML3 Gene

Selected SIMAP similar genes for OLFML3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML3: view

Variants for OLFML3 Gene

Sequence variations from dbSNP and Humsavar for OLFML3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7364 -- 113,982,039(+) GGATG(A/C)CCCAG utr-variant-3-prime
rs2055542 -- 113,981,934(+) CATAC(A/G)GAACT utr-variant-3-prime
rs2292093 -- 113,979,434(+) CACCC(C/T)GCCTC utr-variant-5-prime, upstream-variant-2KB
rs2292094 -- 113,980,031(+) GAGAC(C/T)TCTTC utr-variant-5-prime, intron-variant
rs2938318 -- 113,982,099(+) GTGTT(C/T)TTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OLFML3 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545

Relevant External Links for OLFML3 Gene

HapMap Linkage Disequilibrium report
OLFML3

Disorders for OLFML3 Gene

Relevant External Links for OLFML3

Genetic Association Database (GAD)
OLFML3
genes like me logo Genes that share disorders with OLFML3: view

No data available for UniProtKB/Swiss-Prot for OLFML3 Gene

Publications for OLFML3 Gene

  1. hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. (PMID: 15280020) Zeng L.-C. … Ma W.-J. (FEBS Lett. 2004) 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for OLFML3 Gene

Sources for OLFML3 Gene

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