Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OLFML3 Gene

Aliases for OLFML3 Gene

  • Olfactomedin Like 3 2 3 5
  • HNOEL-Iso 3 4
  • Olfactomedin-Like Protein 3 3
  • Olfactomedin-Like 3 2
  • Olfactomedin, 44-Kd 3
  • HOLF44 4
  • OLF44 3

External Ids for OLFML3 Gene

Previous GeneCards Identifiers for OLFML3 Gene

  • GC01P113821
  • GC01P114234
  • GC01P114323
  • GC01P114522
  • GC01P112380

Summaries for OLFML3 Gene

Entrez Gene Summary for OLFML3 Gene

  • This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for OLFML3 Gene

OLFML3 (Olfactomedin Like 3) is a Protein Coding gene. An important paralog of this gene is OLFML1.

UniProtKB/Swiss-Prot for OLFML3 Gene

  • Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Gene Wiki entry for OLFML3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML3 Gene

Genomics for OLFML3 Gene

Regulatory Elements for OLFML3 Gene

Enhancers for OLFML3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G113944 1.5 Ensembl ENCODE dbSUPER 26.3 -32.2 -32199 4.4 HDGF FOXA2 CREB3L1 ARID4B FEZF1 KLF7 REST TSHZ1 ZNF592 KAT8 OLFML3 AP4B1 DCLRE1B PHTF1 HIPK1-AS1
GH01G113927 1.7 FANTOM5 ENCODE dbSUPER 16.4 -47.5 -47483 8.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC LOC100421402 TRIM33 LRIG2 SIKE1 DCLRE1B OLFML3 AP4B1 RSBN1 AP4B1-AS1 HIPK1
GH01G113978 1.5 Ensembl ENCODE dbSUPER 17.2 +2.5 2501 7.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 TCF12 ZNF121 ZNF143 DEK OLFML3 SYT6 DCLRE1B RPL13AP10
GH01G113937 1.4 Ensembl ENCODE dbSUPER 16.4 -39.9 -39909 4.6 HDAC1 PKNOX1 FOXA2 ZSCAN4 CHAMP1 ZNF121 CBX5 GATA2 SCRT2 ETV6 OLFML3 HIPK1-AS1
GH01G114030 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +55.9 55858 8.9 HDGF FOXA2 PKNOX1 ARNT CREB3L1 ARID4B ZNF2 YY1 ZNF766 CBX5 OLFML3 SYT6 GC01M114036 ENSG00000282048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFML3 on UCSC Golden Path with GeneCards custom track

Promoters for OLFML3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011645 309 601 CTCF PKNOX1 HINFP RB1 ARID4B SIN3A DMAP1 RBBP5 CHD7 ZNF48

Genomic Location for OLFML3 Gene

Chromosome:
1
Start:
113,979,391 bp from pter
End:
114,035,572 bp from pter
Size:
56,182 bases
Orientation:
Plus strand

Genomic View for OLFML3 Gene

Genes around OLFML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML3 Gene

Proteins for OLFML3 Gene

  • Protein details for OLFML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRN5-OLFL3_HUMAN
    Recommended name:
    Olfactomedin-like protein 3
    Protein Accession:
    Q9NRN5
    Secondary Accessions:
    • Q53FR1
    • Q53HV9
    • Q5SQL6
    • Q69AX9
    • Q8NBJ2

    Protein attributes for OLFML3 Gene

    Size:
    406 amino acids
    Molecular mass:
    46010 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OLFML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML3 Gene

Post-translational modifications for OLFML3 Gene

  • Glycosylation at Asn177 and Asn248
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFML3 Gene

No data available for DME Specific Peptides for OLFML3 Gene

Domains & Families for OLFML3 Gene

Protein Domains for OLFML3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRN5

UniProtKB/Swiss-Prot:

OLFL3_HUMAN :
  • Belongs to the OLFML3 family.
Family:
  • Belongs to the OLFML3 family.
genes like me logo Genes that share domains with OLFML3: view

No data available for Gene Families for OLFML3 Gene

Function for OLFML3 Gene

Molecular function for OLFML3 Gene

UniProtKB/Swiss-Prot Function:
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
genes like me logo Genes that share phenotypes with OLFML3: view

Animal Models for OLFML3 Gene

MGI Knock Outs for OLFML3:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML3

CRISPR Products

miRNA for OLFML3 Gene

miRTarBase miRNAs that target OLFML3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLFML3 Gene

Localization for OLFML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML3 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OLFML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle IDA 24769233
genes like me logo Genes that share ontologies with OLFML3: view

Pathways & Interactions for OLFML3 Gene

SuperPathways for OLFML3 Gene

No Data Available

Interacting Proteins for OLFML3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000322273%0d%0a9606.ENSP00000223026%0d%0a9606.ENSP00000350387%0d%0a9606.ENSP00000345849%0d%0a9606.ENSP00000266031%0d%0a9606.ENSP00000361177%0d%0a
Selected Interacting proteins: ENSP00000322273 Q9NRN5-OLFL3_HUMAN for OLFML3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OLFML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with OLFML3: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML3 Gene

Transcripts for OLFML3 Gene

Unigene Clusters for OLFML3 Gene

Olfactomedin-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6: - -

Relevant External Links for OLFML3 Gene

GeneLoc Exon Structure for
OLFML3
ECgene alternative splicing isoforms for
OLFML3

Expression for OLFML3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML3 Gene

This gene is overexpressed in Ovary (16.9), Gallbladder (11.5), and Skin (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFML3 Gene



Protein tissue co-expression partners for OLFML3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLFML3 Gene:

OLFML3

SOURCE GeneReport for Unigene cluster for OLFML3 Gene:

Hs.9315

mRNA Expression by UniProt/SwissProt for OLFML3 Gene:

Q9NRN5-OLFL3_HUMAN
Tissue specificity: Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.

Evidence on tissue expression from TISSUES for OLFML3 Gene

  • Muscle(4.3)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Stomach(4.2)
  • Blood(4)
  • Nervous system(3.7)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with OLFML3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML3 Gene

Orthologs for OLFML3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML3 34 35
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia OLFML3 34 35
  • 91.3 (n)
rat
(Rattus norvegicus)
Mammalia Olfml3 34
  • 89.33 (n)
dog
(Canis familiaris)
Mammalia OLFML3 34 35
  • 89.24 (n)
mouse
(Mus musculus)
Mammalia Olfml3 34 16 35
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFML3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFML3 34 35
  • 67.01 (n)
lizard
(Anolis carolinensis)
Reptilia OLFML3 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml3 34
  • 63.87 (n)
zebrafish
(Danio rerio)
Actinopterygii olfml3b 34 35
  • 59.67 (n)
olfml3a 35
  • 44 (a)
OneToMany
wufb02c05 34
Species where no ortholog for OLFML3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML3 Gene

ENSEMBL:
Gene Tree for OLFML3 (if available)
TreeFam:
Gene Tree for OLFML3 (if available)

Paralogs for OLFML3 Gene

Paralogs for OLFML3 Gene

(2) SIMAP similar genes for OLFML3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML3: view

Variants for OLFML3 Gene

Sequence variations from dbSNP and Humsavar for OLFML3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920761 Uncertain significance 113,980,950(+) TCAGA(A/C/G)TGTGG reference, missense
rs1000038435 -- 113,980,831(+) TAAGA(C/T)TGGAG intron-variant
rs1000215173 -- 113,978,876(+) TTTTC(C/G)TCATG upstream-variant-2KB
rs1002292470 -- 113,980,203(+) TGCAG(G/T)AGTGG intron-variant, utr-variant-5-prime
rs1002949728 -- 113,978,967(+) TTAGA(A/C/G)TAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OLFML3 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV loss 19812545
esv3587240 CNV loss 21293372

Variation tolerance for OLFML3 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML3 Gene

Disorders for OLFML3 Gene

Relevant External Links for OLFML3

Genetic Association Database (GAD)
OLFML3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFML3

No disorders were found for OLFML3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML3 Gene

Publications for OLFML3 Gene

  1. hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. (PMID: 15280020) Zeng L.-C. … Ma W.-J. (FEBS Lett. 2004) 3 4 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for OLFML3 Gene

Sources for OLFML3 Gene

Content
Loading form....