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Aliases & Descriptions for OLFML3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HNOEL-iso 1, 2, 3 | | OLF44 1, 2 | | OTTHUMP00000013761 2 | | hOLF44 3 |
| | | Descriptions |
|---|
| olfactomedin-like 3 2 |
|
| | Search outside databases for aliases for OLFML3 genePrevious GC identifers: GC01P113821 GC01P114234 |
Summaries for OLFML3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OLFL3_HUMAN, Q9NRN5Function: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processesGene Wiki entry for OLFML3 |
Genomic Location for OLFML3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OLFML3 gene 
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1OLFML3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P114323:
(about GC identifiers)
Start:
|
114,323,553 bp from pter |
End:
|
114,326,399 bp from pter |
Size:
|
2,847 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_019273.18
| Proteins for OLFML3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OLFL3_HUMAN, Q9NRN5 (See
protein sequence)Recommended Name: Olfactomedin-like protein 3 precursor Size: 406 amino acids; 46010 Da
Subcellular location: Secreted
Secondary accessions: Q53FR1 Q53HV9 Q5SQL6 Q69AX9 Q8NBJ2Alternative splicing: 3 isoforms: Q9NRN5-1 Q9NRN5-2 Q9NRN5-3 REFSEQ proteins: NP_064575.1
ENSEMBL proteins: ENSP00000322273 ENSP00000376977 ENSP00000358564
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: OLFML3 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for OLFML3: Assays for OLFML3: | Protein
Domains/ Families for OLFML3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NRN5
ProtoNet protein and cluster: Q9NRN5 1 Blocks protein family: IPB003112 Olfactomedin-like
UniProtKB/Swiss-Prot: OLFL3_HUMAN, Q9NRN5Similarity: Belongs to the OLFML3 familySimilarity: Contains 1 olfactomedin-like domain | Gene Function for OLFML3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020190
Applied Biosystems Silencer® siRNAs for OLFML3
Sigma-Aldrich siRNA for OLFML3  Sigma-Aldrich shRNA for OLFML3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020190                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020190                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020190 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020190
UniProtKB/Swiss-Prot: OLFL3_HUMAN, Q9NRN5Function: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Olfml3):
| Pathways & Interactions for OLFML3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for OLFML3 (Q9NRN52) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | About this table
|
Drugs & Compounds for OLFML3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OLFML3
|
Transcripts for OLFML3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020190
Sigma-Aldrich siRNA for OLFML3  Sigma-Aldrich shRNA for OLFML3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020190 REFSEQ mRNAs for OLFML3 gene: NM_020190.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020190               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020190                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020190                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020190  Additional cDNA sequence: AF201945.1 AK075353.1 AK075369.1 AK075479.1 AK075544.1 AK092766.1 AK222471.1 AK223221.1 AK297902.1 AY358954.1 AY464015.1 BC009920.2 CR593069.1 CR595134.1 CR596335.1 CR597657.1 CR598507.1 CR598729.1 CR599952.1 CR601422.1 CR602607.1 CR602631.1 CR603678.1 CR606952.1 CR608311.1 CR608635.1 CR610491.1 CR610535.1 CR610849.1 CR613617.1 CR615262.1 CR617511.1 CR618552.1 CR618591.1 CR624364.1 CR625123.1 19 DOTS entries: DT.317653 DT.100673977 DT.100786765 DT.121415544 DT.100786757 DT.121415557 DT.97809428 DT.100023911 DT.100786769 DT.121415563 DT.121415565 DT.100710650 DT.121415523 DT.100786759 DT.100786770 DT.121415535 DT.121415541 DT.121415545 DT.100720197 24/360 AceView cDNA sequences (see all 360
):BP341546 BP372763 BU855834 CR617511 CB216603 BP373755 BU848988 BP377486 AA359689 BP379283 BU845799 AI903965 CR608311 AW304787 AA678300 CR598507 CD671428 AY464015 AL554606 BP361355 BP371824 BP378996 CR598729 BP376784
highest scoring ESTs for OLFML3:AI078144 AA022654 AA046858 AA046991 AA091730 AA126284 AA216643 AA219570 AA249586 AA297653 Unigene Cluster for OLFML3: Olfactomedin-like 3 Hs.9315 [show with all ESTs]Unigene Representative Sequence: AK075544
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OLFML3 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OLFML3
3 Ensembl transcripts including schematic representations: ENST00000320334
ENST00000393300
ENST00000369551
|
Expression for OLFML3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OLFML3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OLFML3
1 / 2 / 3 3 probe-sets matching OLFML3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCAACAAATT
SOURCE GeneReport for Unigene cluster: Hs.9315 UniProtKB/Swiss-Prot: OLFL3_HUMAN, Q9NRN5Tissue specificity: Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer |
Orthologs for OLFML3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OLFML3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OLFML3
ENSEMBL Gene Tree for OLFML3 | Paralogs for OLFML3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OLFML3 gene
- GLDN2 OLFM42 OLFML12
|
SNPs/Variants for OLFML3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OLFML3 (up to first 250kb)
|
Disorders & Mutations for OLFML3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610088
|
Medical News for OLFML3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OLFML3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for OLFML3 gene (see all 11
):- hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. (PubMed id 15280020)1, 3, 4 Zeng L.-C....Ma W.-J. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- The identification of myocilin-associated proteins in the human trabecular meshwork. (PubMed id 16289162)3 Fautsch M.P....Johnson D.H. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
|
Search for OLFML3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OLFML3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OLFML3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OLFML3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OLFML3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OLFML3:

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Incremental update: 13 Oct 2009
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