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Aliases for OLFML3 Gene

Aliases for OLFML3 Gene

  • Olfactomedin Like 3 2 3 5
  • Olfactomedin-Like 3 2 3
  • HNOEL-Iso 3 4
  • HOLF44 4
  • OLF44 3

External Ids for OLFML3 Gene

Previous GeneCards Identifiers for OLFML3 Gene

  • GC01P113821
  • GC01P114234
  • GC01P114323
  • GC01P114522
  • GC01P112380

Summaries for OLFML3 Gene

GeneCards Summary for OLFML3 Gene

OLFML3 (Olfactomedin Like 3) is a Protein Coding gene. An important paralog of this gene is OLFM1.

UniProtKB/Swiss-Prot for OLFML3 Gene

  • Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.

Gene Wiki entry for OLFML3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML3 Gene

Genomics for OLFML3 Gene

Regulatory Elements for OLFML3 Gene

Promoters for OLFML3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OLFML3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OLFML3 Gene

Chromosome:
1
Start:
113,979,391 bp from pter
End:
114,035,572 bp from pter
Size:
56,182 bases
Orientation:
Plus strand

Genomic View for OLFML3 Gene

Genes around OLFML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML3 Gene

Proteins for OLFML3 Gene

  • Protein details for OLFML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRN5-OLFL3_HUMAN
    Recommended name:
    Olfactomedin-like protein 3
    Protein Accession:
    Q9NRN5
    Secondary Accessions:
    • Q53FR1
    • Q53HV9
    • Q5SQL6
    • Q69AX9
    • Q8NBJ2

    Protein attributes for OLFML3 Gene

    Size:
    406 amino acids
    Molecular mass:
    46010 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OLFML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML3 Gene

Proteomics data for OLFML3 Gene at MOPED

Post-translational modifications for OLFML3 Gene

  • Glycosylation at Asn 177 and Asn 248
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFML3 Gene

Antibody Products

No data available for DME Specific Peptides for OLFML3 Gene

Domains & Families for OLFML3 Gene

Protein Domains for OLFML3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRN5

UniProtKB/Swiss-Prot:

OLFL3_HUMAN :
  • Contains 1 olfactomedin-like domain.
  • Belongs to the OLFML3 family.
Domain:
  • Contains 1 olfactomedin-like domain.
Family:
  • Belongs to the OLFML3 family.
genes like me logo Genes that share domains with OLFML3: view

No data available for Gene Families for OLFML3 Gene

Function for OLFML3 Gene

Molecular function for OLFML3 Gene

UniProtKB/Swiss-Prot Function:
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
genes like me logo Genes that share phenotypes with OLFML3: view

Animal Models for OLFML3 Gene

MGI Knock Outs for OLFML3:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML3

miRNA for OLFML3 Gene

miRTarBase miRNAs that target OLFML3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLFML3 Gene

Localization for OLFML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML3 Gene COMPARTMENTS Subcellular localization image for OLFML3 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for OLFML3 Gene

Pathways & Interactions for OLFML3 Gene

SuperPathways for OLFML3 Gene

No Data Available

Interacting Proteins for OLFML3 Gene

Gene Ontology (GO) - Biological Process for OLFML3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OLFML3 Gene

Drugs & Compounds for OLFML3 Gene

No Compound Related Data Available

Transcripts for OLFML3 Gene

Unigene Clusters for OLFML3 Gene

Olfactomedin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6: - -

Relevant External Links for OLFML3 Gene

GeneLoc Exon Structure for
OLFML3
ECgene alternative splicing isoforms for
OLFML3

Expression for OLFML3 Gene

mRNA expression in normal human tissues for OLFML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML3 Gene

This gene is overexpressed in Ovary (16.9), Gallbladder (11.5), and Skin (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFML3 Gene



SOURCE GeneReport for Unigene cluster for OLFML3 Gene Hs.9315

mRNA Expression by UniProt/SwissProt for OLFML3 Gene

Q9NRN5-OLFL3_HUMAN
Tissue specificity: Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.
genes like me logo Genes that share expression patterns with OLFML3: view

Protein tissue co-expression partners for OLFML3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OLFML3 Gene

Orthologs for OLFML3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLFML3 35
  • 91.3 (n)
  • 97.04 (a)
OLFML3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML3 35
  • 89.24 (n)
  • 96.31 (a)
OLFML3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml3 35
  • 89 (n)
  • 94.09 (a)
Olfml3 16
Olfml3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLFML3 35
  • 99.75 (n)
  • 100 (a)
OLFML3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml3 35
  • 89.33 (n)
  • 94.83 (a)
oppossum
(Monodelphis domestica)
Mammalia OLFML3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFML3 35
  • 67.01 (n)
  • 65.22 (a)
OLFML3 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml3 35
  • 63.87 (n)
  • 58.65 (a)
zebrafish
(Danio rerio)
Actinopterygii olfml3b 35
  • 59.67 (n)
  • 51.81 (a)
wufb02c05 35
olfml3a 36
  • 44 (a)
OneToMany
olfml3b 36
  • 51 (a)
OneToMany
Species with no ortholog for OLFML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML3 Gene

ENSEMBL:
Gene Tree for OLFML3 (if available)
TreeFam:
Gene Tree for OLFML3 (if available)

Paralogs for OLFML3 Gene

Paralogs for OLFML3 Gene

(2) SIMAP similar genes for OLFML3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML3: view

Variants for OLFML3 Gene

Sequence variations from dbSNP and Humsavar for OLFML3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7364 -- 113,982,039(+) GGATG(A/C)CCCAG utr-variant-3-prime
rs2292093 -- 113,979,434(+) CACCC(C/T)GCCTC utr-variant-5-prime
rs2292094 -- 113,980,031(+) GAGAC(C/T)TCTTC intron-variant, utr-variant-5-prime
rs2055542 -- 113,981,934(+) CATAC(A/G)GAACT utr-variant-3-prime
rs2938318 -- 113,982,099(+) GTGTT(C/T)TTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OLFML3 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545

Variation tolerance for OLFML3 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML3 Gene

HapMap Linkage Disequilibrium report
OLFML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML3 Gene

Disorders for OLFML3 Gene

Relevant External Links for OLFML3

Genetic Association Database (GAD)
OLFML3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFML3

No disorders were found for OLFML3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML3 Gene

Publications for OLFML3 Gene

  1. hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. (PMID: 15280020) Zeng L.-C. … Ma W.-J. (FEBS Lett. 2004) 3 4 23 67
  2. Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. (PMID: 24769233) Chiasserini D. … JimAcnez C.R. (J Proteomics 2014) 3
  3. Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: cornea, lens, uvea, and retina. (PMID: 23398349) Rodriguez-Sanchez I.P. … Barrera-Saldana H.A. (J. Med. Primatol. 2013) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for OLFML3 Gene

Sources for OLFML3 Gene

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