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Aliases for OLFML2B Gene

Aliases for OLFML2B Gene

  • Olfactomedin Like 2B 2 3 5
  • Photomedin-2 3 4
  • Olfactomedin-Like Protein 2B 3
  • Olfactomedin-Like 2B 2

External Ids for OLFML2B Gene

Previous GeneCards Identifiers for OLFML2B Gene

  • GC01M159141
  • GC01M158684
  • GC01M160219
  • GC01M133197

Summaries for OLFML2B Gene

Entrez Gene Summary for OLFML2B Gene

  • This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]

GeneCards Summary for OLFML2B Gene

OLFML2B (Olfactomedin Like 2B) is a Protein Coding gene. GO annotations related to this gene include extracellular matrix binding. An important paralog of this gene is OLFML2A.

Additional gene information for OLFML2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2B Gene

Genomics for OLFML2B Gene

Regulatory Elements for OLFML2B Gene

Enhancers for OLFML2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H161961 1.2 Ensembl ENCODE dbSUPER 12.1 +61.8 61827 2.7 JUN EBF1 BATF RELA POLR2A EED FOS ATF7 RUNX3 MAFK OLFML2B FCRLB SDHC ATF6 GC01P161959 PIR31181
GH01H162131 1.2 ENCODE dbSUPER 10.5 -107.6 -107610 2 FOXA2 MLX FEZF1 YY1 ZNF143 SP5 ZHX2 MXD4 REST PPARG C1orf226 OLFML2B SPATA46 MIR4654 GC01M162031
GH01H162560 1.1 ENCODE 9.7 -537.3 -537267 3.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 SP3 DUSP12 DDR2 UHMK1 OLFML2B UAP1 ENSG00000272574
GH01H161973 0.8 Ensembl ENCODE dbSUPER 11.9 +50.5 50498 1 OLFML2B GC01P161959 PIR31181
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFML2B on UCSC Golden Path with GeneCards custom track

Promoters for OLFML2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014787 465 1201 SIN3A ZNF2 ZNF121 GLIS2 KLF7 SP3 ZNF518A ZNF610 PRDM4 CTCF
ENSR00000254959 1465 401 POLR2A

Genomic Locations for OLFML2B Gene

Genomic Locations for OLFML2B Gene
41,274 bases
Minus strand

Genomic View for OLFML2B Gene

Genes around OLFML2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2B Gene

Proteins for OLFML2B Gene

  • Protein details for OLFML2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactomedin-like protein 2B
    Protein Accession:
    Secondary Accessions:
    • B7ZA39
    • Q5VU96
    • Q6NX46
    • Q86X11
    • Q9Y3X6

    Protein attributes for OLFML2B Gene

    750 amino acids
    Molecular mass:
    83999 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E (By similarity).
    • Sequence=CAH71496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OLFML2B Gene


neXtProt entry for OLFML2B Gene

Post-translational modifications for OLFML2B Gene

  • O-glycosylated and N-glycosylated.
  • Glycosylation at posLast=187187, posLast=213213, posLast=343343, Ser357, and Asn695
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OLFML2B Gene

Domains & Families for OLFML2B Gene

Gene Families for OLFML2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFML2B Gene


Suggested Antigen Peptide Sequences for OLFML2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFML2B: view

No data available for UniProtKB/Swiss-Prot for OLFML2B Gene

Function for OLFML2B Gene

Phenotypes From GWAS Catalog for OLFML2B Gene

Gene Ontology (GO) - Molecular Function for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2B: view
genes like me logo Genes that share phenotypes with OLFML2B: view

Animal Model Products

miRNA for OLFML2B Gene

miRTarBase miRNAs that target OLFML2B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2B Gene

Localization for OLFML2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML2B gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OLFML2B: view

Pathways & Interactions for OLFML2B Gene

SuperPathways for OLFML2B Gene

No Data Available

Interacting Proteins for OLFML2B Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)
Selected Interacting proteins: ENSP00000294794 Q68BL8-OLM2B_HUMAN for OLFML2B Gene via STRING IID

Gene Ontology (GO) - Biological Process for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2B: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2B Gene

Drugs & Compounds for OLFML2B Gene

No Compound Related Data Available

Transcripts for OLFML2B Gene

Unigene Clusters for OLFML2B Gene

Olfactomedin-like 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2B Gene

No ASD Table

Relevant External Links for OLFML2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLFML2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFML2B Gene

This gene is overexpressed in Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for OLFML2B Gene

This gene is overexpressed in Rectum (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OLFML2B Gene

Protein tissue co-expression partners for OLFML2B Gene

NURSA nuclear receptor signaling pathways regulating expression of OLFML2B Gene:


SOURCE GeneReport for Unigene cluster for OLFML2B Gene:


Evidence on tissue expression from TISSUES for OLFML2B Gene

  • Eye(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with OLFML2B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2B Gene

Orthologs for OLFML2B Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OLFML2B 33 34
  • 98.71 (n)
(Bos Taurus)
Mammalia OLFML2B 33 34
  • 86.01 (n)
(Rattus norvegicus)
Mammalia Olfml2b 33
  • 84.5 (n)
(Mus musculus)
Mammalia Olfml2b 33 16 34
  • 84.32 (n)
(Canis familiaris)
Mammalia OLFML2B 33 34
  • 83.15 (n)
(Monodelphis domestica)
Mammalia OLFML2B 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia OLFML2B 34
  • 51 (a)
(Gallus gallus)
Aves OLFML2B 33 34
  • 71.03 (n)
(Anolis carolinensis)
Reptilia OLFML2B 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2b 33
  • 64.36 (n)
(Danio rerio)
Actinopterygii olfml2ba 33 34
  • 63.77 (n)
olfml2bb 34
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6867 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea cof-2 34
  • 21 (a)
unc-122 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for OLFML2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2B Gene

Gene Tree for OLFML2B (if available)
Gene Tree for OLFML2B (if available)

Paralogs for OLFML2B Gene

Paralogs for OLFML2B Gene

(7) SIMAP similar genes for OLFML2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLFML2B: view

Variants for OLFML2B Gene

Sequence variations from dbSNP and Humsavar for OLFML2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs142806829 Likely pathogenic 161,998,241(+) CCTGA(A/C/T)GGGTG reference, missense
rs185436876 Likely pathogenic 161,984,849(+) GTTGC(A/C/T)GTAGT reference, missense
rs756430892 Likely pathogenic 161,984,875(+) AAATC(A/C/T)GCTCA reference, missense
rs781712271 Likely pathogenic 162,023,387(+) GAACC(A/C)CAATC reference, missense
rs863224947 Likely pathogenic 161,998,260(-) TCACC(C/T)GGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OLFML2B Gene

Variant ID Type Subtype PubMed ID
nsv831747 CNV loss 17160897
nsv548078 CNV gain 21841781
nsv548077 CNV gain 21841781
nsv470744 CNV gain 18288195
nsv464206 CNV gain 19166990
nsv3287 CNV insertion 18451855
nsv1007108 CNV gain 25217958
esv33393 CNV gain+loss 17666407

Variation tolerance for OLFML2B Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2B Gene

Disorders for OLFML2B Gene

Relevant External Links for OLFML2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OLFML2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2B Gene

Publications for OLFML2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PMID: 19587794) Nolte IM … Jamshidi Y (PloS one 2009) 3 45 60
  3. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 45 60
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking DE … Newton-Cheh C (Nature genetics 2014) 3 60
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 60

Products for OLFML2B Gene

Sources for OLFML2B Gene

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