OLFML2B Gene

Aliases
for OLFML2B gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01M159141 GC01M158684 GC01M160219 GC01M133197

Summaries
for OLFML2B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for OLFML2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_004487.20  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: OLFML2B promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OLFML2B

OLFML2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161952:  view genomic region     (about GC identifiers)

Proteins
for OLFML2B gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for OLFML2B: NX_Q68BL8

Explore proteomics data for OLFML2B at MOPED

Post-translational modifications: 

OLFML2B Human Recombinant Protein Products:

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	antibodies-online peptides for OLFML2B

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OLFML2B Assay Products:

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	antibodies-online kits for OLFML2B (6 products)

Domains /
Families
for OLFML2B gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q68BL8

Find genes that share domains with OLFML2B           About GenesLikeMe

Function
for OLFML2B gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for OLFML2B

miRNA Products:		miRTarBase miRNAs that target OLFML2B: hsa-mir-30b-5p (MIRT046128)
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		Selected qRT-PCR Assays for microRNAs that regulate OLFML2B (see all 15):
		hsa-miR-18a hsa-miR-769-5p hsa-miR-634 hsa-miR-1283 hsa-miR-449c* hsa-miR-323b-3p hsa-miR-624 hsa-miR-507
		SwitchGear 3'UTR luciferase reporter plasmid: OLFML2B 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFML2B

Localization
for OLFML2B gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	2
cytosol	1
endoplasmic reticulum	1
golgi apparatus	1
lysosome	1
nucleus	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for OLFML2B gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for OLFML2B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for OLFML2B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for OLFML2B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OLFML2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCATCTTTGC

About this image

Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
Nucleus Pulposus
TGFbeta3+BMP7-induced chondrocytes
Primitive Streak (Early Embryonic Tissues)
Notochord
Bone (Muscoskeletal System)
TGFbeta3+BMP7-induced chondrocytes
Blood (Hematopoietic System)
Granulocytes Peripheral Blood
Brain (Nervous System)
Cerebral Cortex

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFML2B

Orthologs
for OLFML2B gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for OLFML2B gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for OLFML2B gene

GLDN²  OLFM3²  OLFML3²  OLFML2A²  OLFM1²  OLFM4²  OLFM2²  MYOC²  

OLFML1²  

7 SIMAP similar genes for OLFML2B using alignment to 4 protein entries:     OLM2B_HUMAN (see all proteins):

FLJ00237    OLFM2    OLFM1    MYOC    OLFM3    LPHN1

OLFML2A

Find genes that share paralogs with OLFML2B           About GenesLikeMe

Genomic Variants
for OLFML2B gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OLFML2B (see all 1000)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1434373051,2	C	--	133240138(+)	ATGGG-/AGGGGG	1	--	us2k1		0	--	--	--	--
rs46563461,2	C,F,A,H	--	133240148(+)	GGGCCG/ATGGCA	1	--	us2k1		13		NA WA CSA EA	380
rs1499675951,2	C	--	133240261(+)	CCACCA/GGCATA	1	--	us2k1		0	--	--	--	--
rs1450877511,2		--	133240264(+)	CCAGCA/GTAATT	1	--	us2k1		0	--	--	--	--
rs1150237051,2	C,F	--	133240349(+)	CCTTTG/ATGGGT	1	--	us2k1		1		WA	118
rs1410358381,2	C	--	133240356(+)	GGGTTG/TTTTTG	1	--	us2k1		0	--	--	--	--
rs792678601,2	C,F	--	133240388(+)	AGACTA/GTAAAT	1	--	us2k1		1		NA	120
rs1914002001,2		--	133240420(+)	TAGTTG/TTGCTC	1	--	us2k1		0	--	--	--	--
rs1442206851,2		--	161952574(+)	TGATTA/GAGAAC	1	--	int1		0	--	--	--	--
rs1477643481,2		--	161952592(+)	GGAAGG/TGTGGG	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for OLFML2B (161952982 - 161993644 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for OLFML2B:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv3287	CNV	Insertion	18451855
nsv831747	CNV	Loss	17160897
nsv470744	CNV	Gain	18288195
nsv464206	CNV	Gain	19166990
esv33393	CNV	Gain+Loss	17666407

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing OLFML2B

DNA2.0 Custom Variant and Variant Library Synthesis for OLFML2B

Disorders / Diseases
for OLFML2B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for OLFML2B gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)^{1, 4} McGeachie M....Ramoni M.F. (Circulation 2009)
3. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PubMed id 19587794)^{1, 4} Nolte I.M....Jamshidi Y. (PLoS ONE 2009)
4. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)¹ Reiner A.P....Tang H. (Am. J. Hum. Genet. 2012)
5. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)⁴ Pfeufer A.... Chakravarti A. (Nat. Genet. 2009)
6. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)⁴ Marroni F....Pramstaller P.P. (Circ Cardiovasc Genet 2009)
7. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)¹ Zhou H....Espeseth A.S. (amp 2008)
8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (Nature 2006)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)

External Searches for OLFML2B gene

Genome Databases showing OLFML2B gene

Other Databases showing OLFML2B gene

Specialized Databases showing OLFML2B gene

Products
for OLFML2B gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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