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Aliases for OLFML2B Gene

Aliases for OLFML2B Gene

  • Olfactomedin-Like 2B 2 3
  • Photomedin-2 3 4
  • Olfactomedin-Like Protein 2B 3

External Ids for OLFML2B Gene

Previous GeneCards Identifiers for OLFML2B Gene

  • GC01M159141
  • GC01M158684
  • GC01M160219
  • GC01M133197

Summaries for OLFML2B Gene

GeneCards Summary for OLFML2B Gene

OLFML2B (Olfactomedin-Like 2B) is a Protein Coding gene. GO annotations related to this gene include extracellular matrix binding. An important paralog of this gene is GLDN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2B Gene

Genomics for OLFML2B Gene

Regulatory Elements for OLFML2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OLFML2B Gene

Start:
161,983,192 bp from pter
End:
162,024,382 bp from pter
Size:
41,191 bases
Orientation:
Minus strand

Genomic View for OLFML2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFML2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2B Gene

Proteins for OLFML2B Gene

  • Protein details for OLFML2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL8-OLM2B_HUMAN
    Recommended name:
    Olfactomedin-like protein 2B
    Protein Accession:
    Q68BL8
    Secondary Accessions:
    • B7ZA39
    • Q5VU96
    • Q6NX46
    • Q86X11
    • Q9Y3X6

    Protein attributes for OLFML2B Gene

    Size:
    750 amino acids
    Molecular mass:
    83999 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E (By similarity).
    SequenceCaution:
    • Sequence=CAH71496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OLFML2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2B Gene

Proteomics data for OLFML2B Gene at MOPED

Post-translational modifications for OLFML2B Gene

  • O-glycosylated and N-glycosylated.
  • Glycosylation at Asn187, Asn213, Thr343, Thr346, Ser357, Thr358, Thr361, and Asn695
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFML2B Gene

No data available for DME Specific Peptides for OLFML2B Gene

Domains for OLFML2B Gene

Protein Domains for OLFML2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68BL8

UniProtKB/Swiss-Prot:

OLM2B_HUMAN :
  • Q68BL8
Domain:
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFML2B: view

No data available for Gene Families for OLFML2B Gene

Function for OLFML2B Gene

Gene Ontology (GO) - Molecular Function for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0050840 extracellular matrix binding --
genes like me logo Genes that share ontologies with OLFML2B: view

Phenotypes for OLFML2B Gene

GenomeRNAi human phenotypes for OLFML2B:
genes like me logo Genes that share phenotypes with OLFML2B: view

Animal Model Products

CRISPR Products

miRNA for OLFML2B Gene

miRTarBase miRNAs that target OLFML2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OLFML2B Gene

Localization for OLFML2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML2B Gene COMPARTMENTS Subcellular localization image for OLFML2B gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with OLFML2B: view

Pathways for OLFML2B Gene

SuperPathways for OLFML2B Gene

No Data Available

Interacting Proteins for OLFML2B Gene

Gene Ontology (GO) - Biological Process for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization --
genes like me logo Genes that share ontologies with OLFML2B: view

No data available for Pathways by source for OLFML2B Gene

Transcripts for OLFML2B Gene

Unigene Clusters for OLFML2B Gene

Olfactomedin-like 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFML2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OLFML2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2B Gene

No ASD Table

Relevant External Links for OLFML2B Gene

GeneLoc Exon Structure for
OLFML2B
ECgene alternative splicing isoforms for
OLFML2B

Expression for OLFML2B Gene

mRNA expression in normal human tissues for OLFML2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFML2B Gene

This gene is overexpressed in Artery - Tibial (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for OLFML2B Gene

SOURCE GeneReport for Unigene cluster for OLFML2B Gene Hs.507515

genes like me logo Genes that share expressions with OLFML2B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OLFML2B Gene

Orthologs for OLFML2B Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML2B 35
  • 98.71 (n)
  • 98.53 (a)
OLFML2B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLFML2B 35
  • 86.01 (n)
  • 87.03 (a)
OLFML2B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML2B 35
  • 83.15 (n)
  • 84.1 (a)
OLFML2B 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml2b 35
  • 84.32 (n)
  • 84.32 (a)
Olfml2b 16
Olfml2b 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML2B 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2B 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml2b 35
  • 84.5 (n)
  • 84.46 (a)
chicken
(Gallus gallus)
Aves OLFML2B 35
  • 71.03 (n)
  • 71.97 (a)
OLFML2B 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML2B 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2b 35
  • 64.36 (n)
  • 66.03 (a)
zebrafish
(Danio rerio)
Actinopterygii olfml2ba 35
  • 63.77 (n)
  • 63.52 (a)
olfml2ba 36
  • 41 (a)
OneToMany
olfml2bb 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6867 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 36
  • 21 (a)
ManyToMany
unc-122 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for OLFML2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2B Gene

ENSEMBL:
Gene Tree for OLFML2B (if available)
TreeFam:
Gene Tree for OLFML2B (if available)

Paralogs for OLFML2B Gene

Paralogs for OLFML2B Gene

Selected SIMAP similar genes for OLFML2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OLFML2B: view

Variants for OLFML2B Gene

Sequence variations from dbSNP and Humsavar for OLFML2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1129590 -- 161,983,225(-) AACGC(C/T)TTTTT utr-variant-3-prime
rs1806532 -- 162,002,437(+) TGCCC(C/G)GAGGC intron-variant
rs2247075 -- 161,999,034(+) ccagc(A/G)tgact intron-variant
rs2250993 -- 161,989,705(+) TAACA(A/G)TGCAG intron-variant
rs2250998 -- 161,989,610(+) TTGCT(C/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML2B Gene

Variant ID Type Subtype PubMed ID
esv33393 CNV Gain+Loss 17666407
nsv464206 CNV Gain 19166990
nsv470744 CNV Gain 18288195
nsv831747 CNV Loss 17160897
nsv3287 CNV Insertion 18451855

Relevant External Links for OLFML2B Gene

HapMap Linkage Disequilibrium report
OLFML2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2B Gene

Disorders for OLFML2B Gene

Relevant External Links for OLFML2B

Genetic Association Database (GAD)
OLFML2B
Human Genome Epidemiology (HuGE) Navigator
OLFML2B
genes like me logo Genes that share disorders with OLFML2B: view

No data available for UniProtKB/Swiss-Prot for OLFML2B Gene

Publications for OLFML2B Gene

  1. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PMID: 19587794) Nolte I.M. … Jamshidi Y. (PLoS ONE 2009) 3 48
  2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PMID: 22939635) Reiner A.P. … Tang H. (Am. J. Hum. Genet. 2012) 3
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3

Products for OLFML2B Gene

Sources for OLFML2B Gene

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