Aliases for OLFML2B Gene
Aliases for OLFML2B Gene
External Ids for OLFML2B Gene
- HGNC: 24558
- Entrez Gene: 25903
- Ensembl: ENSG00000162745
- UniProtKB: Q68BL8
Previous GeneCards Identifiers for OLFML2B Gene
- GC01M159141
- GC01M158684
- GC01M160219
- GC01M133197
Summaries for OLFML2B Gene
-
This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
GeneCards Summary for OLFML2B Gene
OLFML2B (Olfactomedin Like 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include extracellular matrix binding. An important paralog of this gene is OLFML2A.
Additional gene information for OLFML2B Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2B Gene
Genomics for OLFML2B Gene
GeneHancer (GH) Regulatory Elements for OLFML2B Gene
Regulatory Element Products
Genomic Locations for OLFML2B Gene
- chr1:161,983,192-162,024,465
- (GRCh38/hg38)
- Size:
- 41,274 bases
- Orientation:
- Minus strand
- chr1:161,952,982-161,993,644
- (GRCh37/hg19)
Genomic View for OLFML2B Gene
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC


RefSeq DNA sequence for OLFML2B Gene
Proteins for OLFML2B Gene
-
Protein details for OLFML2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68BL8-OLM2B_HUMAN
- Recommended name:
- Olfactomedin-like protein 2B
- Protein Accession:
- Q68BL8
- B7ZA39
- Q5VU96
- Q6NX46
- Q86X11
- Q9Y3X6
Protein attributes for OLFML2B Gene
- Size:
- 750 amino acids
- Molecular mass:
- 83999 Da
- Quaternary structure:
-
- Homodimer. Binds to heparin and chondroitin sulfate E (By similarity).
- SequenceCaution:
-
- Sequence=CAH71496.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for OLFML2B Gene
Post-translational modifications for OLFML2B Gene
- O-glycosylated and N-glycosylated.
- Glycosylation at isoforms=187, isoforms=213, isoforms=343, Ser357, and Asn695
Other Protein References for OLFML2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for OLFML2B
- Invitrogen Antibodies for OLFML2B
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Protein Products
-
OriGene Purified Proteins for OLFML2B
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- Search GeneTex for Proteins for OLFML2B
Assay Products
No data available for DME Specific Peptides for OLFML2B Gene
Domains & Families for OLFML2B Gene
Gene Families for OLFML2B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for OLFML2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OLFML2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for OLFML2B Gene
Function for OLFML2B Gene
Phenotypes From GWAS Catalog for OLFML2B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0050840 | extracellular matrix binding | IEA | -- |
Phenotypes for OLFML2B Gene
- GenomeRNAi human phenotypes for OLFML2B:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for OLFML2B gene
-
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- Search ViGene Biosciences for OLFML2B
CRISPR Products
-
OriGene CRISPR knockouts for OLFML2B
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- Overview of 96 available OLFML2B gene related products
- Applied Biological Materials CRISPR for OLFML2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OLFML2B
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miRNA for OLFML2B Gene
- miRTarBase miRNAs that target OLFML2B
miRNA Products
- Search ViGene Biosciences for OLFML2B
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for OLFML2B
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- Overview of 96 available OLFML2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for OLFML2B gene
Clone Products
- Sino Biological Human cDNA Clone for OLFML2B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OLFML2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OLFML2B
-
ViGene Biosciences adenoviral particle packaged cDNA for OLFML2B gene
-
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2B Gene
Localization for OLFML2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for OLFML2B Gene
- Secreted.
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for OLFML2B Gene
Interacting Proteins for OLFML2B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030198 | extracellular matrix organization | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for OLFML2B Gene
Transcripts for OLFML2B Gene
mRNA/cDNA for OLFML2B Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (98) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for OLFML2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for OLFML2B
- genomics-online: gRNA clones - Search results for 96 available OLFML2B gene related products
- Overview of 96 available OLFML2B gene related products
- Applied Biological Materials CRISPR for OLFML2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OLFML2B
- GenScript: Design CRISPR guide RNA sequences for OLFML2B
miRNA Products
- Search ViGene Biosciences for OLFML2B
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for OLFML2B
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- genomics-online: shRNA clones - Search results for 96 available OLFML2B gene related products
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-
ViGene Biosciences ready-to-package AAV shRNAs for OLFML2B gene
Clone Products
- Sino Biological Human cDNA Clone for OLFML2B
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- VectorBuilder custom plasmid, inducible vectors for OLFML2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OLFML2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OLFML2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for OLFML2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Brain (Nervous System)
- Primitive Streak (Early Embryonic Tissues)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for OLFML2B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OLFML2B Gene
NURSA nuclear receptor signaling pathways regulating expression of OLFML2B Gene:
OLFML2BSOURCE GeneReport for Unigene cluster for OLFML2B Gene:
Hs.507515Evidence on tissue expression from TISSUES for OLFML2B Gene
- Eye(4.3)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for OLFML2B
- genomics-online: primer clones - Search results for 96 available OLFML2B gene related products
- Overview of 96 available OLFML2B gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2B Gene
Orthologs for OLFML2B Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | OLFML2B 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | OLFML2B 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Olfml2b 33 |
|
||
mouse (Mus musculus) |
Mammalia | Olfml2b 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | OLFML2B 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | OLFML2B 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | OLFML2B 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | OLFML2B 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | OLFML2B 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | olfml2b 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | olfml2ba 33 34 |
|
||
olfml2bb 34 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | CG6867 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | cof-2 34 |
|
ManyToMany | |
unc-122 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for OLFML2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for OLFML2B Gene
(7) SIMAP similar genes for OLFML2B Gene using alignment to 4 proteins:
Variants for OLFML2B Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs142806829 | likely-pathogenic, not provided | 161,998,241(-) | C/A/T | coding_sequence_variant, missense_variant | |
rs185436876 | likely-pathogenic, not provided | 161,984,849(-) | C/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
rs756430892 | likely-pathogenic, not provided | 161,984,875(-) | C/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
rs781712271 | likely-pathogenic, not provided | 162,023,387(-) | A/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs863224947 | likely-pathogenic, not provided | 161,998,260(-) | G/A | coding_sequence_variant, missense_variant |
Additional Variant Information for OLFML2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OLFML2B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2B Gene
Disorders for OLFML2B Gene
Additional Disease Information for OLFML2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for OLFML2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2B Gene
Publications for OLFML2B Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PMID: 19587794) Nolte IM … Jamshidi Y (PloS one 2009) 3 44 58
- Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 44 58
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking DE … Newton-Cheh C (Nature genetics 2014) 3 58
- Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58
Products for OLFML2B Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OLFML2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for OLFML2B
- Search GeneTex for Proteins for OLFML2B
- ViGene Biosciences adenoviral particle packaged cDNA for OLFML2B gene
- ViGene Biosciences lentiviral particle packaged cDNA for OLFML2B gene
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- Overview of 96 available OLFML2B gene related products
Sources for OLFML2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew