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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OLFML2B Gene

protein-coding   GIFtS: 49
GCID: GC01M161952

Olfactomedin-Like 2B

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactomedin-Like 2B1 2
RP11-227F8.12
Olfactomedin-Like Protein 2B2
photomedin-22
Photomedin-23

External Ids:    HGNC: 245581   Entrez Gene: 259032   Ensembl: ENSG000001627457   UniProtKB: Q68BL83   

Export aliases for OLFML2B gene to outside databases

Previous GC identifers: GC01M159141 GC01M158684 GC01M160219 GC01M133197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OLFML2B Gene: 
OLFML2B (olfactomedin-like 2B) is a protein-coding gene. Diseases associated with OLFML2B include atherosclerosis. GO annotations related to this gene include extracellular matrix binding. An important paralog of this gene is GLDN.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OLFML2B gene promoter:
         RFX1   AML1a   SREBP-1c   Nkx2-5   GATA-1   SREBP-1b   MEF-2A   AREB6   SREBP-1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOLFML2B promoter sequence
   Search SABiosciences Chromatin IP Primers for OLFML2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFML2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

OLFML2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLFML2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161952:  view genomic region     (about GC identifiers)

Start:
161,952,982 bp from pter      End:
161,993,644 bp from pter
Size:
40,663 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OLM2B_HUMAN, Q68BL8 (See protein sequence)
Recommended Name: Olfactomedin-like protein 2B precursor  
Size: 750 amino acids; 83999 Da
Subunit: Homodimer. Binds to heparin and chondroitin sulfate E (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=CAH71496.1; Type=Erroneous gene model prediction;
Secondary accessions: B7ZA39 Q5VU96 Q6NX46 Q86X11 Q9Y3X6
Alternative splicing: 2 isoforms:  Q68BL8-1   Q68BL8-2   

Explore the universe of human proteins at neXtProt for OLFML2B: NX_Q68BL8

Explore proteomics data for OLFML2B at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated and N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68BL8

  • OLFML2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OLFML2B Protein Expression
    REFSEQ proteins: NP_056256.1  
    ENSEMBL proteins: 
     ENSP00000436707   ENSP00000294794   ENSP00000435212   ENSP00000356917   ENSP00000356915  

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    Cloud-Clone Corp. Proteins for OLFML2B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0031012extracellular matrix IEA--

    OLFML2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003112 Olfac-like

    Graphical View of Domain Structure for InterPro Entry Q68BL8

    ProtoNet protein and cluster: Q68BL8

    1 Blocks protein domain: IPB003112 Olfactomedin-like

    UniProtKB/Swiss-Prot: OLM2B_HUMAN, Q68BL8
    Similarity: Contains 1 olfactomedin-like domain


    OLFML2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0050840extracellular matrix binding IEA--
         
    OLFML2B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for OLFML2B:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OLFML2B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OLFML2B 
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    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate OLFML2B (see all 15):
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    SwitchGear 3'UTR luciferase reporter plasmidOLFML2B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFML2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OLFML2B

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization IEA--

    OLFML2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OLFML2B (OLM2B)

    Search CenterWatch for drugs/clinical trials and news about OLFML2B / OLM2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OLFML2B gene: 
    NM_015441.1  

    Unigene Cluster for OLFML2B:

    Olfactomedin-like 2B
    Hs.507515  [show with all ESTs]
    Unigene Representative Sequence: BC067274
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533556 ENST00000294794(uc001gbt.3 uc001gbu.3 uc010pkq.2)
    ENST00000525589 ENST00000367940 ENST00000367938
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate OLFML2B (see all 15):
    hsa-miR-18a hsa-miR-769-5p hsa-miR-634 hsa-miR-1283 hsa-miR-449c* hsa-miR-323b-3p hsa-miR-624 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidOLFML2B 3' UTR sequence
    Inhib. RNA
    Products:
         
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                         Customized lentivirus expression plasmids for stable overexpression of OLFML2B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OLFML2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OLFML2B

    Additional mRNA sequence: 

    AB119054.1 AK301499.1 AK316154.1 AL050137.1 BC047472.1 BC067274.1 BX648975.1 

    2 DOTS entries:

    DT.99964182  DT.100694438 

    24/98 AceView cDNA sequences (see all 98):

    BC067274 BM719150 AW137901 AA489716 AW581166 NM_015441 AB119054 CR600954 
    AA988383 BE645614 BE328022 CA449685 AI289800 AA235255 AI697367 BU627874 
    BQ004219 AA447264 AA931173 AA609525 BG386948 AW581158 AW008717 BF923048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OLFML2B expression in normal human tissues (normalized intensities)      OLFML2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTTTGC
    OLFML2B Expression
    About this image


    OLFML2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
             Normal Human osteoblasts (NHOST)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See OLFML2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OLFML2B

    SOURCE GeneReport for Unigene cluster: Hs.507515
        SABiosciences Custom PCR Arrays for OLFML2B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFML2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OLFML2B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfml2b1 , 5 olfactomedin-like 2B1, 5 84.37(n)1
    84.46(a)1
      1 (76.95 cM)5
    3200781  NM_177068.41  NP_796042.31 
     1706445325 
    chicken
    (Gallus gallus)
    Aves OLFML2B1 olfactomedin-like 2B 71.53(n)
    72.53(a)
      424366  XM_422209.3  XP_422209.3 
    lizard
    (Anolis carolinensis)
    Reptilia OLFML2B6
    olfactomedin-like 2B
    60(a)
    1 ↔ 1
    4(71034684-71063536)
    zebrafish
    (Danio rerio)
    Actinopterygii olfml2b1 olfactomedin-like 2B 58.92(n)
    56.77(a)
      567907  XM_691218.4  XP_696310.4 


    ENSEMBL Gene Tree for OLFML2B (if available)
    TreeFam Gene Tree for OLFML2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OLFML2B gene
    GLDN2  OLFM32  OLFML32  OLFML2A2  OLFM12  OLFM42  OLFM22  MYOC2  
    OLFML12  
    7 SIMAP similar genes for OLFML2B using alignment to 4 protein entries:     OLM2B_HUMAN (see all proteins):
    FLJ00237    OLFM2    OLFM1    MYOC    OLFM3    LPHN1
    OLFML2A

    OLFML2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1000 SNPs in OLFML2B are shown (see all 1000)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434373051,2
    C--133240138(+) ATGGG-/AGGGGG 1 -- us2k10--------
    rs46563461,2
    C,F,A,H--133240148(+) GGGCCG/ATGGCA 1 -- us2k113Minor allele frequency- A:0.14NA WA CSA EA 380
    rs1499675951,2
    C--133240261(+) CCACCA/GGCATA 1 -- us2k10--------
    rs1450877511,2
    --133240264(+) CCAGCA/GTAATT 1 -- us2k10--------
    rs1150237051,2
    C,F--133240349(+) CCTTTG/ATGGGT 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1410358381,2
    C--133240356(+) GGGTTG/TTTTTG 1 -- us2k10--------
    rs792678601,2
    C,F--133240388(+) AGACTA/GTAAAT 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1914002001,2
    --133240420(+) TAGTTG/TTGCTC 1 -- us2k10--------
    rs1442206851,2
    --161952574(+) TGATTA/GAGAAC 1 -- int10--------
    rs1477643481,2
    --161952592(+) GGAAGG/TGTGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for OLFML2B (161952982 - 161993644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OLFML2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3287CNV Insertion18451855
    nsv831747CNV Loss17160897
    nsv470744CNV Gain18288195
    nsv464206CNV Gain19166990
    esv33393CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OLFML2B:    About MalaCards
    atherosclerosis    


    OLFML2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): OLFML2B
    Human Genome Epidemiology (HuGE) Navigator: OLFML2B (2 documents)

    Export disorders for OLFML2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OLFML2B gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with OLFML2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    3. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide a ssociation studies. (PubMed id 19587794)1, 4 Nolte I.M....Jamshidi Y. (2009)
    4. Genome-wide association and population genetic analysi s of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)1 Reiner A.P....Tang H. (2012)
    5. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)4 Pfeufer A....Chakravarti A. (2009)
    6. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)4 Marroni F....Pramstaller P.P. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25903 HGNC: 24558 AceView: OLFML2B Ensembl:ENSG00000162745 euGenes: HUgn25903
    ECgene: OLFML2B H-InvDB: OLFML2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OLFML2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OLFML2B gene:
    Search GeneIP for patents involving OLFML2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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