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OLFML2B Gene

protein-coding GIFtS: 47

GC01M160219

olfactomedin-like 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZP586L151 ^¹
MGC51337 ^²
Photomedin-2 ^³
RP11-227F8.1 ^²
photomedin-2 ^²

Descriptions
olfactomedin-like 2B ^²

External Ids
HGNC: 24558¹
Entrez Gene: 25903²
UniProtKB: Q68BL8³
Ensembl: ENSG00000162745⁷

Search outside databases for aliases for OLFML2B gene

Previous GC identifers: GC01M159141 GC01M158684

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OLFML2B gene

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.1

OLFML2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M160219: (about GC identifiers)

Start:	160,219,606 bp from pter
End:	160,260,268 bp from pter
Size:	40,663 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OLM2B_HUMAN, Q68BL8 (See protein sequence)

Recommended Name: Olfactomedin-like protein 2B precursor

Size: 750 amino acids; 83999 Da

Subunit: Homodimer. Binds to heparin and chondroitin sulfate E (By similarity)

Subcellular location: Secreted (By similarity)

Sequence caution: Sequence=CAH71496.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5VU96 Q6NX46 Q86X11 Q9Y3X6

Alternative splicing: 2 isoforms: Q68BL8-1 Q68BL8-2

Post-translational modifications:

O-glycosylated and N-glycosylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056256.1

ENSEMBL proteins:

ENSP00000294794 ENSP00000356917 ENSP00000356915

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (OLFML2B)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for OLFML2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (OLFML2B), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OLFML2B

Assays for OLFML2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q68BL8

ProtoNet protein and cluster: Q68BL8

1 Blocks protein family: IPB003112 Olfactomedin-like

UniProtKB/Swiss-Prot: OLM2B_HUMAN, Q68BL8

Similarity: Contains 1 olfactomedin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLFML2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLFML2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_034000

Applied Biosystems Silencer® siRNAs for OLFML2B

Sigma-Aldrich siRNA and siRNA Panels for OLFML2B

Sigma-Aldrich shRNA for OLFML2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OLFML2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015441
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015441
untagged cDNA clone in CMV expression vector: NM_015441

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015441

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLFML2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLFML2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLFML2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_034000

Sigma-Aldrich siRNA and siRNA Panels for OLFML2B

Sigma-Aldrich shRNA for OLFML2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015441

REFSEQ mRNAs for OLFML2B gene:

NM_015441.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015441

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015441
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015441
                                 untagged cDNA clone in CMV expression vector: NM_015441

Additional cDNA sequence:

AB119054.1 AK301499.1 AK316154.1 AL050137.1 BC047472.1 BC067274.1 BX648975.1 CR600954.1

3 DOTS entries:

DT.99964182 DT.100694438 DT.87078291

24/98 AceView cDNA sequences (see all 98 ):

AB119054 AW581166 BE645614 AW137901 BM719150 BC067274 BE328022 CR600954

AA988383 NM_015441 AA489716 AI276577 BE046488 AW581126 CA425526 AW007573

BI494399 AI569101 AI289800 BX648975 AA931173 AI419309 N25353 AA428011

highest scoring ESTs for OLFML2B:

AL050137 BC067274 BQ717624 BQ879034 BX648975 AA026537 AA235255 AA427898 AA428011 AA447139

Unigene Cluster for OLFML2B:

Olfactomedin-like 2B

Hs.507515 [show with all ESTs]

Unigene Representative Sequence: BC067274

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000294794 ENST00000367940 ENST00000367938

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OLFML2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OLFML2B

¹ / ² / ³

3 probe-sets matching OLFML2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36007_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL050137	0.80	1.00	0.91	1
213125_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AW007573	0.60	1.00	0.82	1
213125_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCATCTTTGC

SOURCE GeneReport for Unigene cluster: Hs.507515
Expression variation in blood from EXPOLDB for OLFML2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OLFML2B gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OLFML2B¹	--	olfactomedin-like 2B	79.23(n) 78.95(a)	488661 XM_545778.2 XP_545778.2
chimpanzee (Pan troglodytes)	OLFML2B¹	--	olfactomedin-like 2B	98.71(n) 98.53(a)	457462 XM_513950.2 XP_513950.2
cow (Bos taurus)	OLFML2B¹	--	olfactomedin-like 2B	86.01(n) 87.03(a)	513053 XM_590675.3 XP_590675.2
rat (Rattus norvegicus)	Olfml2b¹	--	olfactomedin-like 2B	84.55(n) 84.59(a)	304960 XM_222868.4 XP_222868.4
mouse (Mus musculus)	Olfml2b^{1, 5}	1⁵	olfactomedin-like 2B^{1, 5}	84.55(n)¹ 84.59(a)¹	320078¹ NM_177068.3¹ NP_796042.2¹ AI467542⁵ AK003791⁵ (see all 12)

About this table Species with no ortholog for OLFML2B

ENSEMBL Gene Tree for OLFML2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OLFML2B gene

OLFML2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/272 NCBI SNPs in OLFML2B are shown (see all 272 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 155)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1129590^1,2	A,C,F,H	160219639(-)	`AACGCT/CTTTTT`	1	--	ut3¹ trp³		11		EU EA WA NA	958
	rs10918361^1,2	A,C,F,H	160219371(+)	`ACAGAA/GAAATG`	1	--	ng5¹		11		EU EA WA NA	980
	rs2499836^1,2	A,C,F,H	160234305(-)	`CTGGGC/TGGGGA`	1	W/R	mis¹		13		EA NA EU WA	2166
	rs4657136^1,2	A,C,F,H	160260634(+)	`GTTAGT/GGATCT`	1	--	ng3¹		8		EA NA EU WA	636
	rs12130792^1,2	C,F,H	160259816(+)	`CGAAGT/CAGAGA`	1	C/Y	mis¹ ese³		8		EU EA WA	828
	rs16834849^1,2	F,H	160219732(+)	`CTGCTC/TCTGGT`	1	--	ut3¹ ese³		7		NA EU EA WA	562
--	rs12039519^1,2	F,H	160220024(+)	`cgtgcG/Acgcac`	1	--	ut3¹ ese³		4		EU EA WA	416
--	rs12407643^1,2	C	160220026(+)	`TGCGCA/GCACAC`	1	--	ut3¹		0	--	--	--	--
	rs4657135^1,2	C	160260467(+)	`GGCTGA/GGGGTG`	1	--	ng3¹		0	--	--	--	--
	rs12022536^1,2	A,C,F,H	160242858(+)	`TGTTCA/GTTTTC`	1	N/N	syn¹		13		EA NA EU WA	1118

About this table

HapMap Linkage Disequilibrium images for OLFML2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for OLFML2B gene:

The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25903	HGNC: 24558	AceView: OLFML2B	Ensembl:ENSG00000162745	euGenes: HUgn25903
ECgene: OLFML2B	H-InvDB: OLFML2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OLFML2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OLFML2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OLFML2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OLFML2B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OLFML2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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OLFML2B Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for OLFML2B

Summaries
for OLFML2B

Genomic Location
for OLFML2B

Proteins
for OLFML2B

Protein Domains/
Families
for OLFML2B

Gene Function
for OLFML2B

Pathways & Interactions
for OLFML2B

Drugs & Compounds
for OLFML2B

Transcripts
for OLFML2B

Expression
for OLFML2B

Orthologs
for OLFML2B

Paralogs
for OLFML2B

SNPs/Variants
for OLFML2B

Disorders & Mutations
for OLFML2B

Medical News
for OLFML2B

Publications
for OLFML2B

Search for OLFML2B

Genome Databases showing OLFML2B

Other Databases showing OLFML2B

Specialized Databases showing OLFML2B

Licensable Technologies
for OLFML2B

Services
for OLFML2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OLFML2B Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor OLFML2B

Summariesfor OLFML2B

Genomic Locationfor OLFML2B

Proteinsfor OLFML2B

Protein Domains/Familiesfor OLFML2B

Gene Functionfor OLFML2B

Pathways & Interactionsfor OLFML2B

Drugs & Compoundsfor OLFML2B

Transcriptsfor OLFML2B

Expression for OLFML2B

Orthologsfor OLFML2B

Paralogsfor OLFML2B

SNPs/Variantsfor OLFML2B

Disorders & Mutationsfor OLFML2B

Medical Newsfor OLFML2B

Publicationsfor OLFML2B

Search for OLFML2B

Genome Databases showing OLFML2B

Other Databases showing OLFML2B

Specialized Databases showing OLFML2B

Licensable Technologiesfor OLFML2B

Servicesfor OLFML2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OLFML2B

Summaries
for OLFML2B

Genomic Location
for OLFML2B

Proteins
for OLFML2B

Protein Domains/
Families
for OLFML2B

Gene Function
for OLFML2B

Pathways & Interactions
for OLFML2B

Drugs & Compounds
for OLFML2B

Transcripts
for OLFML2B

Expression
for OLFML2B

Orthologs
for OLFML2B

Paralogs
for OLFML2B

SNPs/Variants
for OLFML2B

Disorders & Mutations
for OLFML2B

Medical News
for OLFML2B

Publications
for OLFML2B

Licensable Technologies
for OLFML2B

Services
for OLFML2B