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OLFML2A Gene

protein-coding GIFtS: 49

GC09P126579

olfactomedin-like 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ00237 ^¹, ²
OTTHUMP00000022113 ^²
OTTHUMP00000022114 ^²
OTTHUMP00000022115 ^²
PRO34319 ^²
Photomedin-1 ^³
photomedin-1 ^²

Descriptions
olfactomedin-like 2A ^²

External Ids
HGNC: 27270¹
Entrez Gene: 169611²
UniProtKB: Q68BL7³
Ensembl: ENSG00000185585⁷

Search outside databases for aliases for OLFML2A gene

Previous GC identifers: GC09P122916 GC09P124618

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OLFML2A gene

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q34.11

OLFML2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P126579: (about GC identifiers)

Start:	126,579,258 bp from pter
End:	126,616,982 bp from pter
Size:	37,725 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OLM2A_HUMAN, Q68BL7 (See protein sequence)

Recommended Name: Olfactomedin-like protein 2A precursor

Size: 652 amino acids; 73054 Da

Subunit: Homodimer. Binds to heparin and chondroitin sulfate E (By similarity)

Subcellular location: Secreted (By similarity)

Secondary accessions: Q5JTM5 Q5JTM6 Q6UXW1 Q7Z5V3

Alternative splicing: 3 isoforms: Q68BL7-1 Q68BL7-2 Q68BL7-3

Post-translational modifications:

May be cleaved at Lys-295 after secretion (By similarity)¹

O-glycosylated but not N-glycosylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_872293.2

ENSEMBL proteins:

ENSP00000339766 ENSP00000288815 ENSP00000336425 ENSP00000362682

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (OLFML2A)
	Human Recombinant Proteins from Abnova (OLFML2A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016020	membrane	IEA	--
GO:0031012	extracellular matrix	IEA	--

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Antibodies for OLFML2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OLFML2A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (OLFML2A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OLFML2A

Assays for OLFML2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q68BL7

ProtoNet protein and cluster: Q68BL7

1 Blocks protein family: IPB003112 Olfactomedin-like

UniProtKB/Swiss-Prot: OLM2A_HUMAN, Q68BL7

Similarity: Contains 1 olfactomedin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLFML2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLFML2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182487

Applied Biosystems Silencer® siRNAs for OLFML2A

Sigma-Aldrich siRNA and siRNA Panels for OLFML2A

Sigma-Aldrich shRNA for OLFML2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OLFML2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_182487
Myc/DDK tagged cDNA clone in CMV expression vector: NM_182487
untagged cDNA clones in CMV expression vector (see all 3): AK097045

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182487

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042803	protein homodimerization activity	IEA	--
GO:0050840	extracellular matrix binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OLFML2A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OLFML2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OLFML2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182487

Sigma-Aldrich siRNA and siRNA Panels for OLFML2A

Sigma-Aldrich shRNA for OLFML2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_182487

REFSEQ mRNAs for OLFML2A gene:

NM_182487.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_182487

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182487
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182487
                                 untagged cDNA clones in CMV expression vector (see all 3): AK097045

Additional cDNA sequence:

AB119055.1 AK054867.1 AK074164.1 AK074709.1 AK092255.1 AL050002.1 AY191222.1 AY358185.1

BC011693.2 BC013281.2 BC054001.1

9 DOTS entries:

DT.213902 DT.100025524 DT.91933538 DT.100009885 DT.100879918 DT.121207924 DT.40207052 DT.91678358

DT.97857766

24/130 AceView cDNA sequences (see all 130 ):

AA558432 BG674628 AA722453 BC011693 BU102139 BI771423 AA834000 AW608184

AY358185 AI708197 BU615755 AW838578 BE741025 BF476366 BQ574861 AW016772

AI300631 W79450 AL709935 AI150837 AA373700 AI142368 CA388701 AW025490

highest scoring ESTs for OLFML2A:

AL050002 AA126142 AA126348 AA318161 AA358995 AA373700 AA374476 AA534884 AA558432 AA582175

Unigene Cluster for OLFML2A:

Olfactomedin-like 2A

Hs.357004 [show with all ESTs]

Unigene Representative Sequence: NM_182487

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:							-		-						-
SP2:							-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for OLFML2A

4 Ensembl transcripts including schematic representations:

ENST00000342100 ENST00000288815 ENST00000331715 ENST00000373580

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OLFML2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OLFML2A

¹ / ² / ³

4 probe-sets matching OLFML2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38312_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.42	AL050002	1.00	1.00	1.00	1
54582_at²^{, 3}	U95-C	1	1.00	1.00	0.94	0.60	AI123582	0.80	1.00	0.91	1
213075_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL050002	1.00	1.00	1.00	1
213075_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OLFML2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: ATCAAAGGTT

SOURCE GeneReport for Unigene cluster: Hs.357004
Expression variation in blood from EXPOLDB for OLFML2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OLFML2A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OLFML2A¹	--	olfactomedin-like 2A	87.55(n) 88.31(a)	491336 XM_548457.2 XP_548457.2
chimpanzee (Pan troglodytes)	OLFML2A¹	--	olfactomedin-like 2A	98.88(n) 98.93(a)	464726 XM_520250.2 XP_520250.2
cow (Bos taurus)	OLFML2A¹	--	olfactomedin-like 2A	89.23(n) 90.05(a)	516730 XM_594888.3 XP_594888.3
rat (Rattus norvegicus)	Olfml2a¹	--	olfactomedin-like 2A	81.87(n) 82.9(a)	296708 XM_231192.4 XP_231192.4
mouse (Mus musculus)	Olfml2a^{1, 5}	2⁵	olfactomedin-like 2A^{1, 5}	82.69(n)¹ 83.98(a)¹	241327¹ NM_172854.2¹ NP_766442.1¹ AK028569⁵ AK030069⁵ (see all 12)

About this table Species with no ortholog for OLFML2A

ENSEMBL Gene Tree for OLFML2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OLFML2A gene

OLFML2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/174 NCBI SNPs in OLFML2A are shown (see all 174 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4838215^1,2	A,C,F,H	126613571(+)	`GATGGC/TACAGT`	1	--	ut3¹ ese³		8		EU EA WA	838
	rs2416952^1,2	A,C,F,H	126612988(+)	`GAGGTC/TTTTAG`	1	--	ut3¹ ese³		6		EU EA WA NA	600
	rs8975^1,2	A,C,F,H	126616908(+)	`TTGTAA/TGTTGC`	1	--	ut3¹ ese³		8		MN EU EA WA NA	742
	rs7874348^1,2	C,F,H	126606199(+)	`ACAACG/ACCCTC`	1	A/T	mis¹		4		EU EA WA	400
	rs3739761^1,2	C,F,H	126615789(+)	`CTCCAA/GTCATA`	1	--	ut3¹ ese³		15		EA NA EU WA	2708
	rs2094374^1,2	A,C,F	126613850(-)	`GGGCTG/ATGTGG`	1	--	ut3¹ ese³		3		NA	122
--	rs16927649^1,2	C,F,H	126609986(+)	`AGCTCG/AAGACG`	1	Q/R	mis¹ ese³		7		NA EU EA WA	536
--	rs4838217^1,2	A,C	126617226(+)	`GCTTGA/GGGTCT`	1	--	ng3¹		0	--	--	--	--
	rs11788516^1,2	C	126615621(+)	`CAGGCA/GCTGGT`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs4836994^1,2	C	126617191(+)	`AATCTG/TTCAAA`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OLFML2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for OLFML2A gene:

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 169611	HGNC: 27270	AceView: OLFML2A	Ensembl:ENSG00000185585	euGenes: HUgn169611
ECgene: OLFML2A	H-InvDB: OLFML2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OLFML2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OLFML2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OLFML2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OLFML2A		Antibodies for OLFML2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OLFML2A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OLFML2A)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (OLFML2A)

Search OriGene for OLFML2A

Search Tocris compounds for OLFML2A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OLFML2A

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OLFML2A Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for OLFML2A

Summaries
for OLFML2A

Genomic Location
for OLFML2A

Proteins
for OLFML2A

Protein Domains/
Families
for OLFML2A

Gene Function
for OLFML2A

Pathways & Interactions
for OLFML2A

Drugs & Compounds
for OLFML2A

Transcripts
for OLFML2A

Expression
for OLFML2A

Orthologs
for OLFML2A

Paralogs
for OLFML2A

SNPs/Variants
for OLFML2A

Disorders & Mutations
for OLFML2A

Medical News
for OLFML2A

Publications
for OLFML2A

Search for OLFML2A

Genome Databases showing OLFML2A

Other Databases showing OLFML2A

Specialized Databases showing OLFML2A

Licensable Technologies
for OLFML2A

Services
for OLFML2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OLFML2A Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor OLFML2A

Summariesfor OLFML2A

Genomic Locationfor OLFML2A

Proteinsfor OLFML2A

Protein Domains/Familiesfor OLFML2A

Gene Functionfor OLFML2A

Pathways & Interactionsfor OLFML2A

Drugs & Compoundsfor OLFML2A

Transcriptsfor OLFML2A

Expression for OLFML2A

Orthologsfor OLFML2A

Paralogsfor OLFML2A

SNPs/Variantsfor OLFML2A

Disorders & Mutationsfor OLFML2A

Medical Newsfor OLFML2A

Publicationsfor OLFML2A

Search for OLFML2A

Genome Databases showing OLFML2A

Other Databases showing OLFML2A

Specialized Databases showing OLFML2A

Licensable Technologiesfor OLFML2A

Servicesfor OLFML2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OLFML2A

Summaries
for OLFML2A

Genomic Location
for OLFML2A

Proteins
for OLFML2A

Protein Domains/
Families
for OLFML2A

Gene Function
for OLFML2A

Pathways & Interactions
for OLFML2A

Drugs & Compounds
for OLFML2A

Transcripts
for OLFML2A

Expression
for OLFML2A

Orthologs
for OLFML2A

Paralogs
for OLFML2A

SNPs/Variants
for OLFML2A

Disorders & Mutations
for OLFML2A

Medical News
for OLFML2A

Publications
for OLFML2A

Licensable Technologies
for OLFML2A

Services
for OLFML2A