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Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin Like 2A 2 3 5
  • Photomedin-1 3 4
  • Olfactomedin-Like Protein 2A 3
  • Olfactomedin-Like 2A 2
  • PRO34319 3

External Ids for OLFML2A Gene

Previous GeneCards Identifiers for OLFML2A Gene

  • GC09P122916
  • GC09P124618
  • GC09P126579
  • GC09P127539
  • GC09P097152

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin Like 2A) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is OLFML2B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

Regulatory Elements for OLFML2A Gene

Enhancers for OLFML2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G124799 1.5 Ensembl ENCODE dbSUPER 11.5 +24.2 24156 3.3 PKNOX1 SIN3A ZBTB7B GLIS2 ZNF766 GATA2 FOS KDM4B DEK ZNF263 WDR38 RPL35 ARPC5L OLFML2A GAPVD1 RNU6-1020P MIR181A2HG PIR55692
GH09G124804 1.2 ENCODE dbSUPER 7.8 +28.3 28251 1.4 HDGF HDAC1 CREB3L1 NFRKB ARID4B SIN3A GLIS2 ZNF263 SP3 SP5 OLFML2A PIR55692
GH09G124834 1.4 Ensembl ENCODE dbSUPER 6.5 +58.0 58049 2.3 NFIB KLF17 ZNF121 GLIS2 ZNF366 SCRT2 RCOR1 FOS CEBPB NFIC ARPC5L OLFML2A WDR38 PIR55692
GH09G124808 1.6 Ensembl ENCODE dbSUPER 5.5 +34.4 34371 6.1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 FOS DEK SP5 MXD4 GOLGA1 OLFML2A PIR55692 WDR38
GH09G124831 1.4 Ensembl ENCODE dbSUPER 5.3 +55.3 55256 1.9 SIN3A FEZF1 GTF3C2 GLIS2 ZNF263 ZNF592 MEF2D SMARCA4 GLIS1 KDM1A GOLGA1 PRPS1P2 ARPC5L OLFML2A WDR38 PIR55692
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFML2A on UCSC Golden Path with GeneCards custom track

Promoters for OLFML2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241338 242 801 ATF1 ARNT SIN3A TCF12 GATA2 ELK1 FOS JUNB NCOA1 ZNF592

Genomic Location for OLFML2A Gene

Chromosome:
9
Start:
124,777,158 bp from pter
End:
124,814,891 bp from pter
Size:
37,734 bases
Orientation:
Plus strand

Genomic View for OLFML2A Gene

Genes around OLFML2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL7-OLM2A_HUMAN
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Q68BL7
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    Size:
    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2A Gene

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains & Families for OLFML2A Gene

Protein Domains for OLFML2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFML2A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OLFML2A Gene

Function for OLFML2A Gene

Gene Ontology (GO) - Molecular Function for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2A: view
genes like me logo Genes that share phenotypes with OLFML2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML2A

CRISPR Products

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Pathways & Interactions for OLFML2A Gene

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362682%0d%0a9606.ENSP00000345849%0d%0a9606.ENSP00000223026%0d%0a9606.ENSP00000266031%0d%0a9606.ENSP00000350387%0d%0a9606.ENSP00000345395%0d%0a
Selected Interacting proteins: ENSP00000362682 Q68BL7-OLM2A_HUMAN for OLFML2A Gene via STRING IID

Gene Ontology (GO) - Biological Process for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2A Gene

Drugs & Compounds for OLFML2A Gene

No Compound Related Data Available

Transcripts for OLFML2A Gene

Unigene Clusters for OLFML2A Gene

Olfactomedin-like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
OLFML2A
ECgene alternative splicing isoforms for
OLFML2A

Expression for OLFML2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML2A Gene

This gene is overexpressed in Platelet (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFML2A Gene



NURSA nuclear receptor signaling pathways regulating expression of OLFML2A Gene:

OLFML2A

SOURCE GeneReport for Unigene cluster for OLFML2A Gene:

Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene:

Q68BL7-OLM2A_HUMAN
Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.

Evidence on tissue expression from TISSUES for OLFML2A Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with OLFML2A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2A Gene

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML2A 34 35
  • 98.88 (n)
cow
(Bos Taurus)
Mammalia OLFML2A 34 35
  • 88.51 (n)
dog
(Canis familiaris)
Mammalia OLFML2A 34 35
  • 86.75 (n)
mouse
(Mus musculus)
Mammalia Olfml2a 34 16 35
  • 83.31 (n)
rat
(Rattus norvegicus)
Mammalia Olfml2a 34
  • 82.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2A 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML2A 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFML2A 34 35
  • 74.14 (n)
lizard
(Anolis carolinensis)
Reptilia OLFML2A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2a 34
  • 64.92 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330530 34
  • 66.78 (n)
olfml2a 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6867 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 35
  • 18 (a)
ManyToMany
unc-122 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for OLFML2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2A Gene

ENSEMBL:
Gene Tree for OLFML2A (if available)
TreeFam:
Gene Tree for OLFML2A (if available)

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

(4) SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations from dbSNP and Humsavar for OLFML2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000175242 -- 124,810,583(+) ATACT(G/T)GCTTC utr-variant-3-prime
rs1000291329 -- 124,810,767(+) GACAG(A/C)CCCAT utr-variant-3-prime
rs1000339169 -- 124,797,975(+) AGGGA(-/AGG)AGAAC intron-variant
rs1000375878 -- 124,780,501(+) TCCAG(A/G)CCAGG intron-variant
rs1000391465 -- 124,798,364(+) AGGCA(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
esv2761558 CNV gain 21179565
esv3621725 CNV loss 21293372
nsv524034 CNV loss 19592680
nsv831721 CNV gain 17160897

Variation tolerance for OLFML2A Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2A Gene

Disorders for OLFML2A Gene

Relevant External Links for OLFML2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFML2A

No disorders were found for OLFML2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2A Gene

Publications for OLFML2A Gene

  1. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L. … Patrakka J. (Kidney Int. 2013) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 3 64
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64

Products for OLFML2A Gene

Sources for OLFML2A Gene

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