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Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin-Like 2A 2 3
  • Photomedin-1 3 4
  • Olfactomedin-Like Protein 2A 3
  • PRO34319 3

External Ids for OLFML2A Gene

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin-Like 2A) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is GLDN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

Genomic Location for OLFML2A Gene

Start:
124,777,158 bp from pter
End:
124,814,891 bp from pter
Size:
37,734 bases
Orientation:
Plus strand

Genomic View for OLFML2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Regulatory Elements for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL7-OLM2A_HUMAN
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Q68BL7
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    Size:
    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2A Gene

Proteomics data for OLFML2A Gene at MOPED

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains for OLFML2A Gene

Protein Domains for OLFML2A Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

OLM2A_HUMAN
Domain:
  • Contains 1 olfactomedin-like domain.:
    • Q68BL7
genes like me logo Genes that share domains with OLFML2A: view

No data available for Gene Families for OLFML2A Gene

Function for OLFML2A Gene

Gene Ontology (GO) - Molecular Function for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML2A Gene COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Pathways for OLFML2A Gene

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362682%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000362682 Q68BL7-OLM2A_HUMAN for OLFML2A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

No data available for Pathways by source for OLFML2A Gene

Transcripts for OLFML2A Gene

Unigene Clusters for OLFML2A Gene

Olfactomedin-like 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
OLFML2A
ECgene alternative splicing isoforms for
OLFML2A

Expression for OLFML2A Gene

mRNA expression in normal human tissues for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OLFML2A Gene

SOURCE GeneReport for Unigene cluster for OLFML2A Gene Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene

Q68BL7-OLM2A_HUMAN
Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.
genes like me logo Genes that share expressions with OLFML2A: view

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML2A 36
  • 98.88 (n)
  • 98.93 (a)
OLFML2A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLFML2A 36
  • 88.51 (n)
  • 88.83 (a)
OLFML2A 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML2A 36
  • 86.75 (n)
  • 87.5 (a)
OLFML2A 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml2a 36
  • 83.31 (n)
  • 84.69 (a)
Olfml2a 16
Olfml2a 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML2A 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2A 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml2a 36
  • 82.27 (n)
  • 83.31 (a)
chicken
(Gallus gallus)
Aves OLFML2A 36
  • 74.14 (n)
  • 69.57 (a)
OLFML2A 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML2A 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2a 36
  • 64.92 (n)
  • 66.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330530 36
  • 66.78 (n)
  • 65.23 (a)
olfml2a 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6867 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 37
  • 18 (a)
ManyToMany
unc-122 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for OLFML2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2A Gene

ENSEMBL:
Gene Tree for OLFML2A (if available)
TreeFam:
Gene Tree for OLFML2A (if available)

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

Selected SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations from dbSNP and Humsavar for OLFML2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8975 -- 124,814,808(+) TTGTA(A/T)GTTGC utr-variant-3-prime
rs14622 -- 124,814,778(-) AAAAA(A/T)AAAAA utr-variant-3-prime
rs750169 -- 124,799,678(+) GCACA(C/G)TCAGC upstream-variant-2KB, intron-variant
rs750691 -- 124,800,509(-) AGTCA(C/T)GCAGA upstream-variant-2KB, intron-variant
rs750692 -- 124,800,340(-) TGTCA(C/G)CTCCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV Gain 17160897
nsv524034 CNV Loss 19592680

Relevant External Links for OLFML2A Gene

HapMap Linkage Disequilibrium report
OLFML2A

Disorders for OLFML2A Gene

No disorders were found for OLFML2A Gene.

No data available for UniProtKB/Swiss-Prot for OLFML2A Gene

Publications for OLFML2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L. … Patrakka J. (Kidney Int. 2013) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OLFML2A Gene

Sources for OLFML2A Gene

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