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Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin Like 2A 2 3 5
  • Olfactomedin-Like 2A 2 3
  • Photomedin-1 3 4
  • PRO34319 3

External Ids for OLFML2A Gene

Previous GeneCards Identifiers for OLFML2A Gene

  • GC09P122916
  • GC09P124618
  • GC09P126579
  • GC09P127539
  • GC09P097152

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin Like 2A) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is OLFM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

Regulatory Elements for OLFML2A Gene

Enhancers for OLFML2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OLFML2A on UCSC Golden Path with GeneCards custom track

Promoters for OLFML2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OLFML2A on UCSC Golden Path with GeneCards custom track

Genomic Location for OLFML2A Gene

124,777,158 bp from pter
124,814,891 bp from pter
37,734 bases
Plus strand

Genomic View for OLFML2A Gene

Genes around OLFML2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene


neXtProt entry for OLFML2A Gene

Proteomics data for OLFML2A Gene at MOPED

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains & Families for OLFML2A Gene

Protein Domains for OLFML2A Gene


Suggested Antigen Peptide Sequences for OLFML2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 olfactomedin-like domain.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFML2A: view

No data available for Gene Families for OLFML2A Gene

Function for OLFML2A Gene

genes like me logo Genes that share phenotypes with OLFML2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML2A

CRISPR Products

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

Jensen Localization Image for OLFML2A Gene COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for OLFML2A Gene

Pathways & Interactions for OLFML2A Gene

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362682 Q68BL7-OLM2A_HUMAN for OLFML2A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for OLFML2A Gene


No data available for Pathways by source and SIGNOR curated interactions for OLFML2A Gene

Drugs & Compounds for OLFML2A Gene

No Compound Related Data Available

Transcripts for OLFML2A Gene

Unigene Clusters for OLFML2A Gene

Olfactomedin-like 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLFML2A Gene

mRNA expression in normal human tissues for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML2A Gene

This gene is overexpressed in Platelet (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML2A Gene

SOURCE GeneReport for Unigene cluster for OLFML2A Gene Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene

Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.
genes like me logo Genes that share expression patterns with OLFML2A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for OLFML2A Gene

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OLFML2A 35
  • 88.51 (n)
  • 88.83 (a)
  • 88 (a)
(Canis familiaris)
Mammalia OLFML2A 35
  • 86.75 (n)
  • 87.5 (a)
  • 85 (a)
(Mus musculus)
Mammalia Olfml2a 35
  • 83.31 (n)
  • 84.69 (a)
Olfml2a 16
Olfml2a 36
  • 80 (a)
(Pan troglodytes)
Mammalia OLFML2A 35
  • 98.88 (n)
  • 98.93 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Olfml2a 35
  • 82.27 (n)
  • 83.31 (a)
(Monodelphis domestica)
Mammalia OLFML2A 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia OLFML2A 36
  • 72 (a)
(Gallus gallus)
Aves OLFML2A 35
  • 74.14 (n)
  • 69.57 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia OLFML2A 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2a 35
  • 64.92 (n)
  • 66.56 (a)
(Danio rerio)
Actinopterygii LOC100330530 35
  • 66.78 (n)
  • 65.23 (a)
olfml2a 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6867 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea cof-2 36
  • 18 (a)
unc-122 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for OLFML2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2A Gene

Gene Tree for OLFML2A (if available)
Gene Tree for OLFML2A (if available)

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

(4) SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations from dbSNP and Humsavar for OLFML2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7874348 - 124,804,099(+) ACAAC(A/G)CCCTC intron-variant, reference, missense
rs16927649 - 124,807,886(+) AGCTC(A/G)AGACG reference, missense
rs750169 -- 124,799,678(+) GCACA(C/G)TCAGC intron-variant, upstream-variant-2KB
rs750691 -- 124,800,509(-) AGTCA(C/T)GCAGA intron-variant, upstream-variant-2KB
rs750692 -- 124,800,340(-) TGTCA(C/G)CTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV Gain 17160897
nsv524034 CNV Loss 19592680

Variation tolerance for OLFML2A Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OLFML2A Gene

Disorders for OLFML2A Gene

Relevant External Links for OLFML2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OLFML2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2A Gene

Publications for OLFML2A Gene

  1. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L. … Patrakka J. (Kidney Int. 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 3
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for OLFML2A Gene

Sources for OLFML2A Gene