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Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin-Like 2A 2 3
  • Photomedin-1 3 4
  • PRO34319 3

External Ids for OLFML2A Gene

Previous GeneCards Identifiers for OLFML2A Gene

  • GC09P122916
  • GC09P124618
  • GC09P126579
  • GC09P127539
  • GC09P097152

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin-Like 2A) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is GLDN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

Regulatory Elements for OLFML2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OLFML2A Gene

Chromosome:
9
Start:
124,777,158 bp from pter
End:
124,814,891 bp from pter
Size:
37,734 bases
Orientation:
Plus strand

Genomic View for OLFML2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL7-OLM2A_HUMAN
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Q68BL7
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    Size:
    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2A Gene

Proteomics data for OLFML2A Gene at MOPED

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains & Families for OLFML2A Gene

Protein Domains for OLFML2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68BL7

UniProtKB/Swiss-Prot:

OLM2A_HUMAN :
  • Contains 1 olfactomedin-like domain.
Domain:
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFML2A: view

No data available for Gene Families for OLFML2A Gene

Function for OLFML2A Gene

Gene Ontology (GO) - Molecular Function for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Phenotypes for OLFML2A Gene

genes like me logo Genes that share phenotypes with OLFML2A: view

Animal Model Products

CRISPR Products

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFML2A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML2A Gene COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Pathways & Interactions for OLFML2A Gene

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362682%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q68BL7-OLM2A_HUMAN ENSP00000362682 for OLFML2A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2A Gene

Drugs & Compounds for OLFML2A Gene

No Compound Related Data Available

Transcripts for OLFML2A Gene

Unigene Clusters for OLFML2A Gene

Olfactomedin-like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFML2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
OLFML2A
ECgene alternative splicing isoforms for
OLFML2A

Expression for OLFML2A Gene

mRNA expression in normal human tissues for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML2A Gene

This gene is overexpressed in Platelet (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFML2A Gene



SOURCE GeneReport for Unigene cluster for OLFML2A Gene Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene

Q68BL7-OLM2A_HUMAN
Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.
genes like me logo Genes that share expression patterns with OLFML2A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for OLFML2A Gene

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OLFML2A 35
  • 88.51 (n)
  • 88.83 (a)
OLFML2A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML2A 35
  • 86.75 (n)
  • 87.5 (a)
OLFML2A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml2a 35
  • 83.31 (n)
  • 84.69 (a)
Olfml2a 16
Olfml2a 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OLFML2A 35
  • 98.88 (n)
  • 98.93 (a)
OLFML2A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml2a 35
  • 82.27 (n)
  • 83.31 (a)
oppossum
(Monodelphis domestica)
Mammalia OLFML2A 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2A 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFML2A 35
  • 74.14 (n)
  • 69.57 (a)
OLFML2A 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML2A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2a 35
  • 64.92 (n)
  • 66.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330530 35
  • 66.78 (n)
  • 65.23 (a)
olfml2a 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6867 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 36
  • 18 (a)
ManyToMany
unc-122 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for OLFML2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2A Gene

ENSEMBL:
Gene Tree for OLFML2A (if available)
TreeFam:
Gene Tree for OLFML2A (if available)

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

(4) SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations from dbSNP and Humsavar for OLFML2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8975 -- 124,814,808(+) TTGTA(A/T)GTTGC utr-variant-3-prime
rs14622 -- 124,814,778(-) AAAAA(A/T)AAAAA utr-variant-3-prime
rs750169 -- 124,799,678(+) GCACA(C/G)TCAGC upstream-variant-2KB, intron-variant
rs750691 -- 124,800,509(-) AGTCA(C/T)GCAGA upstream-variant-2KB, intron-variant
rs750692 -- 124,800,340(-) TGTCA(C/G)CTCCC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV Gain 17160897
nsv524034 CNV Loss 19592680

Variation tolerance for OLFML2A Gene

Residual Variation Intolerance Score: 91.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML2A Gene

HapMap Linkage Disequilibrium report
OLFML2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2A Gene

Disorders for OLFML2A Gene

Relevant External Links for OLFML2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFML2A
genes like me logo Genes that share disorders with OLFML2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2A Gene

Publications for OLFML2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L. … Patrakka J. (Kidney Int. 2013) 67
  3. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for OLFML2A Gene

Sources for OLFML2A Gene

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