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Aliases for OLFML1 Gene

Aliases for OLFML1 Gene

  • Olfactomedin Like 1 2 3 5
  • Olfactomedin-Like Protein 1 3
  • Olfactomedin-Like 1 2
  • MVAL564 3
  • UNQ564 3

External Ids for OLFML1 Gene

Previous GeneCards Identifiers for OLFML1 Gene

  • GC11P007472
  • GC11P007165

Summaries for OLFML1 Gene

GeneCards Summary for OLFML1 Gene

OLFML1 (Olfactomedin Like 1) is a Protein Coding gene. An important paralog of this gene is OLFML3.

Additional gene information for OLFML1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML1 Gene

Genomics for OLFML1 Gene

Regulatory Elements for OLFML1 Gene

Enhancers for OLFML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H007985 1.1 ENCODE 24.2 +501.8 501820 2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3F TMEM9B-AS1 ZNF214 OLFML1 ST5 SNORA3B CASC23 TUB PIR63023 COX6CP5
GH11H006693 1.4 Ensembl ENCODE dbSUPER 13.3 -790.4 -790370 3 HDAC1 PKNOX1 TCF12 ZNF121 ATF7 CAVIN1 ZBTB11 HDAC8 NR2F2 ZNF592 RRP8 OLFML1 GVINP2 OR2AG2 ILK LOC644169 ENSG00000254400 TIMM10B ENSG00000254641 TAF10
GH11H006616 1.3 ENCODE dbSUPER 13.3 -867.0 -866952 3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS RRP8 OLFML1 MRPL17 RPL21P94 LOC644169 TIMM10B DCHS1 ILK ENSG00000255680 TAF10
GH11H007518 1.5 Ensembl ENCODE dbSUPER 10.6 +37.1 37131 7 HDGF MLX ARID4B DMAP1 YY1 ATF7 RUNX3 JUNB REST MIER2 LOC100506258 LOC105376535 OLFML1 GC11M007514 GC11M007541
GH11H007571 1.5 Ensembl ENCODE dbSUPER 10.6 +90.6 90566 9 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 BRCA1 YY1 SLC30A9 OLFML1 OVCH2 PPFIBP2 NLRP10 LOC105376535 GC11M007541
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OLFML1 on UCSC Golden Path with GeneCards custom track

Promoters for OLFML1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036356 431 800 HNF4G HNF4A KDM1A

Genomic Location for OLFML1 Gene

Chromosome:
11
Start:
7,485,369 bp from pter
End:
7,511,897 bp from pter
Size:
26,529 bases
Orientation:
Plus strand

Genomic View for OLFML1 Gene

Genes around OLFML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML1 Gene

Proteins for OLFML1 Gene

  • Protein details for OLFML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWY5-OLFL1_HUMAN
    Recommended name:
    Olfactomedin-like protein 1
    Protein Accession:
    Q6UWY5
    Secondary Accessions:
    • B4DP03
    • Q569G4

    Protein attributes for OLFML1 Gene

    Size:
    402 amino acids
    Molecular mass:
    45951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OLFML1 Gene

Post-translational modifications for OLFML1 Gene

Other Protein References for OLFML1 Gene

No data available for DME Specific Peptides for OLFML1 Gene

Domains & Families for OLFML1 Gene

Gene Families for OLFML1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OLFML1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFML1: view

No data available for UniProtKB/Swiss-Prot for OLFML1 Gene

Function for OLFML1 Gene

genes like me logo Genes that share phenotypes with OLFML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLFML1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OLFML1 Gene

Localization for OLFML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OLFML1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLFML1 Gene

Pathways & Interactions for OLFML1 Gene

SuperPathways for OLFML1 Gene

No Data Available

Interacting Proteins for OLFML1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332511%0d%0a9606.ENSP00000350387%0d%0a9606.ENSP00000345849%0d%0a9606.ENSP00000266031%0d%0a9606.ENSP00000223026%0d%0a9606.ENSP00000352138%0d%0a
Selected Interacting proteins: ENSP00000332511 Q6UWY5-OLFL1_HUMAN for OLFML1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OLFML1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OLFML1 Gene

Drugs & Compounds for OLFML1 Gene

No Compound Related Data Available

Transcripts for OLFML1 Gene

Unigene Clusters for OLFML1 Gene

Olfactomedin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OLFML1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2:

Relevant External Links for OLFML1 Gene

GeneLoc Exon Structure for
OLFML1
ECgene alternative splicing isoforms for
OLFML1

Expression for OLFML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML1 Gene

This gene is overexpressed in Ovary (18.8), Gallbladder (9.8), and Prostate (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OLFML1 Gene



Protein tissue co-expression partners for OLFML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLFML1 Gene:

OLFML1

SOURCE GeneReport for Unigene cluster for OLFML1 Gene:

Hs.503500

mRNA Expression by UniProt/SwissProt for OLFML1 Gene:

Q6UWY5-OLFL1_HUMAN
Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart.

Evidence on tissue expression from TISSUES for OLFML1 Gene

  • Pancreas(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with OLFML1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML1 Gene

Orthologs for OLFML1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML1 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia OLFML1 33 34
  • 88.53 (n)
mouse
(Mus musculus)
Mammalia Olfml1 33 16 34
  • 84.43 (n)
cow
(Bos Taurus)
Mammalia OLFML1 33 34
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Olfml1 33
  • 84.16 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFML1 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves OLFML1 33 34
  • 60.47 (n)
lizard
(Anolis carolinensis)
Reptilia OLFML1 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml1 33
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003048 33
  • 52.03 (n)
BX294190.1 34
  • 41 (a)
OneToOne
Species where no ortholog for OLFML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML1 Gene

ENSEMBL:
Gene Tree for OLFML1 (if available)
TreeFam:
Gene Tree for OLFML1 (if available)

Paralogs for OLFML1 Gene

Paralogs for OLFML1 Gene

(4) SIMAP similar genes for OLFML1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OLFML1: view

Variants for OLFML1 Gene

Sequence variations from dbSNP and Humsavar for OLFML1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000244523 -- 7,500,911(+) AAAAG(A/C)ATTAT intron-variant
rs1000412057 -- 7,491,936(+) AGCCC(A/C)CCCAT intron-variant
rs1000526057 -- 7,511,015(+) AGTAA(C/T)ACAAT utr-variant-3-prime
rs1000535892 -- 7,511,257(+) CCCAA(C/T)TCTAG utr-variant-3-prime
rs1000598683 -- 7,500,595(+) AAAAT(A/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML1 Gene

Variant ID Type Subtype PubMed ID
dgv576e59 CNV tandem duplication 20981092
esv3360494 CNV duplication 20981092
nsv1129510 CNV tandem duplication 24896259
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OLFML1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML1 Gene

Disorders for OLFML1 Gene

Relevant External Links for OLFML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OLFML1

No disorders were found for OLFML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML1 Gene

Publications for OLFML1 Gene

  1. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PMID: 18708057) Wan B … Han ZG (FEBS letters 2008) 3 4 22 60
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for OLFML1 Gene

Sources for OLFML1 Gene

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