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OLFML1 Gene

protein-coding   GIFtS: 49

GC11P007463
olfactomedin-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MVAL564 2
UNQ564 1, 2
Descriptions
olfactomedin-like 1 2
External Ids
HGNC: 244731
Entrez Gene: 2832982
UniProtKB: Q6UWY53
Ensembl: ENSG000001838017
Search outside databases for aliases for OLFML1 gene

Previous GC identifer: GC11P007472

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OLFML1 gene  

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

OLFML1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007463:     (about GC identifiers)

Start:
7,463,289 bp from pter
End:
7,489,178 bp from pter
Size:
25,890 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OLFL1_HUMAN, Q6UWY5 (See protein sequence)
Recommended Name: Olfactomedin-like protein 1 precursor  
Size: 402 amino acids; 45921 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B4DP03 Q569G4

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_940876.1  

    ENSEMBL proteins: 
    ENSP00000332511 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (OLFML1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    About this table

    Antibodies for OLFML1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (OLFML1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for OLFML1

    Assays for OLFML1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR003112 Olfac-like


       GeneDecks  OLFML1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6UWY5

    ProtoNet protein and cluster: Q6UWY5

    1 Blocks protein family: IPB003112 Olfactomedin-like

    UniProtKB/Swiss-Prot: OLFL1_HUMAN, Q6UWY5
    Similarity: Contains 1 olfactomedin-like domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OLFML1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_208606

                  Applied Biosystems Silencer® siRNAs for OLFML1

                  Sigma-Aldrich siRNA for OLFML1  
                         Sigma-Aldrich shRNA for OLFML1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198474
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198474
                                     untagged cDNA clone in CMV expression vector: NM_198474 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_198474

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for OLFML1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (OLFML1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_208606

                  Sigma-Aldrich siRNA for OLFML1  
                         Sigma-Aldrich shRNA for OLFML1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_198474  

    REFSEQ mRNAs for OLFML1 gene: 

    NM_198474.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_198474  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198474
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198474
                                     untagged cDNA clone in CMV expression vector: NM_198474 

    Additional cDNA sequence: 

    AK297778.1 AK298137.1 AY358591.1 BC035895.1 BC092488.1 BX647908.1 CR591365.1 CR624488.1 

    3 DOTS entries:

    DT.101981601  DT.100811414  DT.100743511 

    24/64 AceView cDNA sequences (see all 64 ):

    CR624488 CR591365 AY358591 BC035895 NM_198474 N76979 AL543108 AI131455 
    BF846695 BF002933 AW305097 C02489 AA346531 AL701890 N55492 BX390365 
    BX402849 AA706390 BE140233 AL701891 AI183360 BI837102 BE677684 AA361785 

    highest scoring ESTs for OLFML1:

    AY358591 BC035895 BX647908 AA361785 AA378396 AA614561 AA706390 AI290480 AL543108 AL701891 

    Unigene Cluster for OLFML1:

    Olfactomedin-like 1
    Hs.503500  [show with all ESTs]
    Unigene Representative Sequence: BX647908


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1

    ExUns: 1a · 1b ^ 2a · 2b ^ 3
    SP1:                              
    SP2:                              

    About this scheme

    ECgene alternative splicing isoforms for OLFML1

    1 Ensembl transcript including schematic representation:
    ENST00000329293  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    OLFML1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for OLFML1

    1 / 2 / 3

    3 probe-sets matching OLFML1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36695_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AI290480 0.60 1.00 0.82 1

    217525_at2, 3 U133-A 1 1.00 1.00 -- -- AW305097 0.60 1.00 0.82 1

    217525_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCTGCACAAG

    SOURCE GeneReport for Unigene cluster: Hs.503500

    Expression variation in blood from EXPOLDB for OLFML1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for OLFML1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OLFML11   -- olfactomedin-like 1 88.45(n)
    88.03(a)
    476839  XM_534043.2  XP_534043.2 
    chimpanzee
    (Pan troglodytes)
    OLFML11   -- olfactomedin-like 1 99.17(n)
    99(a)
    466426  XM_521825.2  XP_521825.1 
    cow
    (Bos taurus)
    OLFML11   -- olfactomedin-like 1 82.67(n)
    81.5(a)
    531068  NM_001035385.1  NP_001030462.1 
    rat
    (Rattus norvegicus)
    Olfml11   -- olfactomedin-like 1 84.08(n)
    83.33(a)
    361621  NM_001013192.1  NP_001013210.1 
    mouse
    (Mus musculus)
    Olfml11, 5 75
    olfactomedin-like 11, 5 84.29(n)1
    81.94(a)1
    2441981  NM_172907.21  NP_766495.11 
     AI8472675  AK0329485  (see all 11)
    About this table        Species with no ortholog for OLFML1

    ENSEMBL Gene Tree for OLFML1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for OLFML1 gene
    GLDN2  OLFML32  OLFM42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/123 NCBI SNPs in OLFML1 are shown (see all 123 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 75)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs108397931,2
    A,C,F,H7462537(+) GGAAAC/TACAGG 1 -- ng51 tfbs32Minor allele frequency- T:0.14EA 170
    rs38845961,2
    A,C,F,H7488751(-) GAATTA/CAATGA 1 -- ut3120Minor allele frequency- C:0.39NS EU EA WA NA 1506
    rs108397941,2
    A,C,F,H7462553(+) TGACTC/GCTGGA 1 -- ng517Minor allele frequency- G:0.23EU EA WA 692
    rs47581891,2
    A,C,F,H7462102(+) GCACCC/TTTAAG 1 -- ng516Minor allele frequency- N:0.01EA NA 386
    rs108397911,2
    A,C,F,H7461909(+) AGTATG/AGCATG 1 -- ng512Minor allele frequency- A:0.15EA 164
    rs39230921,2
    A,F,H7461367(+) GGTGCG/AGCAGG 1 -- ng513Minor allele frequency- A:0.07EU EA 272
    rs128030461,2
    C,F,H7487561(+) GCCGAG/ACATTG 1 T/A mis18Minor allele frequency- A:0.02EU EA WA 836
    rs43635701,2
    A,C,F7461391(+) CCTTAC/TCCACC 1 -- ng513Minor allele frequency- T:0.47NA 114
    rs128056481,2
    C,F,H7466142(+) CATCGA/TATCAG 1 V/E mis16Minor allele frequency- T:0.14EU WA EA 652
    --
    rs108397891,2
    A,C7461664(+) CAGAGA/CTGAGA 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for OLFML1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for OLFML1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 283298 HGNC: 24473 AceView: OLFML1 Ensembl:ENSG00000183801 euGenes: HUgn283298
    ECgene: OLFML1 H-InvDB: OLFML1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for OLFML1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OLFML1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for OLFML1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for OLFML1 Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for OLFML1

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