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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OLFML1 Gene

protein-coding GIFtS: 45
GCID: GC11P007463

olfactomedin-like 1

Search for OLFML1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Olfactomedin-Like 1¹ ²
UNQ564¹ ²
MVAL564²
Olfactomedin-Like Protein 1²

External Ids:	HGNC: 24473¹	Entrez Gene: 283298²	Ensembl: ENSG00000183801⁷	UniProtKB: Q6UWY5³

Export aliases for OLFML1 gene to outside databases

Previous GC identifers: GC11P007472 GC11P007165

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OLFML1 gene promoter:
NF-AT Gfi-1 SRY NF-AT4 NF-AT2 HSF2 FOXO1a NF-AT3 FOXO1 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OLFML1 promoter sequence

Search SABiosciences Chromatin IP Primers for OLFML1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OLFML1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15

OLFML1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OLFML1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P007463: view genomic region (about GC identifiers)

Start:	7,506,600 bp from pter	End:	7,532,608 bp from pter
Size:	26,009 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OLFL1_HUMAN, Q6UWY5 (See protein sequence)

Recommended Name: Olfactomedin-like protein 1 precursor

Size: 402 amino acids; 45951 Da

Subcellular location: Secreted

Secondary accessions: B4DP03 Q569G4

Explore the universe of human proteins at neXtProt for OLFML1: NX_Q6UWY5

Post-translational modifications:

Highly N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWY5

OLFML1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_940876.2

ENSEMBL proteins:

ENSP00000433455 ENSP00000332511 ENSP00000431558 ENSP00000434813

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	Uscn Proteins for OLFML1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

OLFML1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OLFML1 for domains About GeneDecksing

1 InterPro domain/family:

IPR003112 Olfac-like

Graphical View of Domain Structure for InterPro Entry Q6UWY5

ProtoNet protein and cluster: Q6UWY5

1 Blocks protein family: IPB003112 Olfactomedin-like

UniProtKB/Swiss-Prot: OLFL1_HUMAN, Q6UWY5

Similarity: Contains 1 olfactomedin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Animal Models:
Mouse knock-out Olfml1^tm1Lex for OLFML1
1 MGI phenotypic allele

for Olfml1 (no phenotypes)

OLFML1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OLFML1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about OLFML1 / OLFL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OLFML1 gene:

NM_198474.3

Unigene Cluster for OLFML1:

Olfactomedin-like 1

Hs.503500 [show with all ESTs]

Unigene Representative Sequence: NM_198474

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000530135 ENST00000329293(uc001mfi.3 uc010raz.2 uc010rba.2)

ENST00000534244 ENST00000528308 ENST00000528758

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Additional cDNA sequence:

AK297778.1 AK298137.1 AY358591.1 BC035895.1 BC092488.1 BX647908.1

3 DOTS entries:

DT.101981601 DT.100743511 DT.100811414

24/64 AceView cDNA sequences (see all 64):

AL543108 AY358591 BF002933 N76979 BC035895 CR591365 AL701890 AA346531

NM_198474 C02489 AI131455 BF846695 AW305097 CR624488 AI685753 BM678629

AW852232 BX110040 AL701891 BX402850 BI837102 BE677684 AA614561 BX647908

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3
SP1:
SP2:

ECgene alternative splicing isoforms for OLFML1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OLFML1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGCACAAG

About this image

OLFML1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Bone

Zeugopod Epiphyseal End

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See OLFML1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OLFML1

SOURCE GeneReport for Unigene cluster: Hs.503500

UniProtKB/Swiss-Prot: OLFL1_HUMAN, Q6UWY5

Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for OLFML1 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	OLFML1¹	olfactomedin-like 1	59.56(n) 52.03(a)		428842 XM_426398.2 XP_426398.3
lizard (Anolis carolinensis)	Reptilia	OLFML1⁶	--	47(a)	1 ↔ 1	GL343237.1(1915384-1930154)
zebrafish (Danio rerio)	Actinopterygii	LOC100003048¹	olfactomedin-like protein 1-like	53.09(n) 46.5(a)		100003048 XM_001342657.3 XP_001342693.2
fruit fly (Drosophila melanogaster)	Insecta	CG6867⁶	--	7(a)	1 → many	X(17917903-17922294)
worm (Caenorhabditis elegans)	Secernentea	cof-2⁶ unc-122⁶	UNCoordinated family member (unc-122)	13(a) 12(a)	many ↔ many many ↔ many	I(6250573-6252823) I(14872151-14875367)

ENSEMBL Gene Tree for OLFML1 (if available)
TreeFam Gene Tree for OLFML1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OLFML1 gene

GLDN² OLFML2B² OLFM3² MYOC² OLFML3² OLFML2A² OLFM2² OLFM1²

OLFM4²

4 SIMAP similar genes for OLFML1 using alignment to 3 protein entries: OLFL1_HUMAN (see all proteins):

DKFZp686H1812 OLFML3 MYOC OLFM1

OLFML1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79276754^1,2	C,F,	--	7504629(+)	`GATACC/TGGGGT`	1	--	us2k¹		2		WA NA	238
rs76266949^1,2		--	7504643(+)	`AAAGCG/AGAAGG`	1	--	us2k¹		2		CSA WA	120
rs150182834^1,2		--	7504717(+)	`AGCAAC/TGGTCA`	1	--	us2k¹		0	--	--	--	--
rs147882339^1,2		--	7504736(+)	`GGTTAC/TGTGTA`	1	--	us2k¹		0	--	--	--	--
rs141413972^1,2		--	7504769(+)	`ATTTCA/GTCCAG`	1	--	us2k¹		0	--	--	--	--
rs60709972^1,2	C,	--	7504774(+)	`GTCCAG/ACTGCA`	1	--	us2k¹		3		CSA WA EA	240
rs114212096^1,2	F,	--	7504783(+)	`CAGGTC/GTAGGT`	1	--	us2k¹		1		WA	118
rs3923092^1,2	C,F,A,H,	--	7504791(+)	`GGTGCG/AGCAGG`	1	--	us2k¹		9		NS EA NA WA	636
rs4363570^1,2	C,F,A,H,	--	7504815(+)	`CCTTAC/TCCACC`	1	--	us2k¹		13		NA WA CSA EA	485
rs4384369^1,2	C,F,A,H,	--	7504831(+)	`CCCACG/TGAGGA`	1	--	us2k¹		12		NA WA CSA EA	377

HapMap Linkage Disequilibrium report for OLFML1 (7506600 - 7532608 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OLFML1: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for OLFML1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OLFML1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OLFML1)

Utopia: connect your pdf to the dynamic
world of online information

hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PubMed id 18708057)^{1, 2, 9} Wan B....Han Z.G. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283298	HGNC: 24473	AceView: OLFML1	Ensembl:ENSG00000183801	euGenes: HUgn283298
ECgene: OLFML1	H-InvDB: OLFML1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OLFML1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OLFML1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OLFML1 gene:
Search GeneIP for patents involving OLFML1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OLFML1

	SwitchGear 3'UTR luciferase reporter plasmids for OLFML1
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ThermoFisher Antibodies for OLFML1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OLFML1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OLFML1 gene at Home site.

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OLFML1 Gene

olfactomedin-like 1

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Export list of displayed genes

OLFML1 Gene

olfactomedin-like 1

Aliasesfor OLFML1 gene

Summariesfor OLFML1 gene

Genomic Viewsfor OLFML1 gene

Proteinsfor OLFML1 gene

Protein Domains /Familiesfor OLFML1 gene

Functionfor OLFML1 gene

Pathways & Interactionsfor OLFML1 gene

Drugs & Compoundsfor OLFML1 gene

Transcriptsfor OLFML1 gene

Expression for OLFML1 gene

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Genomic Variantsfor OLFML1 gene

Disorders / Diseasesfor OLFML1 gene

Publicationsfor OLFML1 gene

External Searches for OLFML1 gene

Genome Databases showing OLFML1 gene

Other Databases showing OLFML1 gene

Specialized Databases showing OLFML1 gene

Intellectual Propertyfor OLFML1 gene

Productsfor OLFML1 gene

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Aliases
for OLFML1 gene

Summaries
for OLFML1 gene

Genomic Views
for OLFML1 gene

Proteins
for OLFML1 gene

Protein Domains /
Families
for OLFML1 gene

Function
for OLFML1 gene

Pathways & Interactions
for OLFML1 gene

Drugs & Compounds
for OLFML1 gene

Transcripts
for OLFML1 gene

Expression
for OLFML1 gene

Orthologs
for OLFML1 gene

Paralogs
for OLFML1 gene

Genomic Variants
for OLFML1 gene

Disorders / Diseases
for OLFML1 gene

Publications
for OLFML1 gene

Intellectual Property
for OLFML1 gene

Products
for OLFML1 gene