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Aliases for OLFML1 Gene

Aliases for OLFML1 Gene

  • Olfactomedin Like 1 2 3 5
  • Olfactomedin-Like Protein 1 3
  • Olfactomedin-Like 1 2
  • MVAL564 3
  • UNQ564 3

External Ids for OLFML1 Gene

Previous GeneCards Identifiers for OLFML1 Gene

  • GC11P007472
  • GC11P007165

Summaries for OLFML1 Gene

GeneCards Summary for OLFML1 Gene

OLFML1 (Olfactomedin Like 1) is a Protein Coding gene. Diseases associated with OLFML1 include Endometrial Disease. An important paralog of this gene is OLFML3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML1 Gene

Genomics for OLFML1 Gene

Regulatory Elements for OLFML1 Gene

Enhancers for OLFML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OLFML1 on UCSC Golden Path with GeneCards custom track

Promoters for OLFML1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for OLFML1 Gene

7,485,369 bp from pter
7,511,897 bp from pter
26,529 bases
Plus strand

Genomic View for OLFML1 Gene

Genes around OLFML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML1 Gene

Proteins for OLFML1 Gene

  • Protein details for OLFML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactomedin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DP03
    • Q569G4

    Protein attributes for OLFML1 Gene

    402 amino acids
    Molecular mass:
    45951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OLFML1 Gene

Post-translational modifications for OLFML1 Gene

Other Protein References for OLFML1 Gene

No data available for DME Specific Peptides for OLFML1 Gene

Domains & Families for OLFML1 Gene

Protein Domains for OLFML1 Gene


Suggested Antigen Peptide Sequences for OLFML1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 olfactomedin-like domain.
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFML1: view

No data available for Gene Families for OLFML1 Gene

Function for OLFML1 Gene

genes like me logo Genes that share phenotypes with OLFML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OLFML1 Gene

Localization for OLFML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML1 Gene


Subcellular locations from

Jensen Localization Image for OLFML1 Gene COMPARTMENTS Subcellular localization image for OLFML1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OLFML1: view

Pathways & Interactions for OLFML1 Gene

SuperPathways for OLFML1 Gene

No Data Available

Interacting Proteins for OLFML1 Gene

Gene Ontology (GO) - Biological Process for OLFML1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OLFML1 Gene

Drugs & Compounds for OLFML1 Gene

No Compound Related Data Available

Transcripts for OLFML1 Gene

Unigene Clusters for OLFML1 Gene

Olfactomedin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3

Relevant External Links for OLFML1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLFML1 Gene

mRNA expression in normal human tissues for OLFML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML1 Gene

This gene is overexpressed in Ovary (18.8), Gallbladder (9.8), and Prostate (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML1 Gene

Protein tissue co-expression partners for OLFML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLFML1 Gene:


SOURCE GeneReport for Unigene cluster for OLFML1 Gene:


mRNA Expression by UniProt/SwissProt for OLFML1 Gene:

Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart.
genes like me logo Genes that share expression patterns with OLFML1: view

Primer Products

No data available for mRNA differential expression in normal tissues for OLFML1 Gene

Orthologs for OLFML1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OLFML1 34
  • 84.33 (n)
  • 84.33 (a)
  • 84 (a)
(Canis familiaris)
Mammalia OLFML1 34
  • 88.53 (n)
  • 88.28 (a)
  • 88 (a)
(Mus musculus)
Mammalia Olfml1 34
  • 84.43 (n)
  • 82.38 (a)
Olfml1 16
Olfml1 35
  • 81 (a)
(Pan troglodytes)
Mammalia OLFML1 34
  • 99.25 (n)
  • 99.25 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Olfml1 34
  • 84.16 (n)
  • 83.58 (a)
(Monodelphis domestica)
Mammalia OLFML1 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
-- 35
  • 50 (a)
(Gallus gallus)
Aves OLFML1 34
  • 60.47 (n)
  • 52.56 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia OLFML1 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml1 34
  • 53.77 (n)
  • 41.14 (a)
(Danio rerio)
Actinopterygii LOC100003048 34
  • 52.03 (n)
  • 43.9 (a)
BX294190.1 35
  • 41 (a)
Species where no ortholog for OLFML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML1 Gene

Gene Tree for OLFML1 (if available)
Gene Tree for OLFML1 (if available)

Paralogs for OLFML1 Gene

Paralogs for OLFML1 Gene

(4) SIMAP similar genes for OLFML1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OLFML1: view

Variants for OLFML1 Gene

Sequence variations from dbSNP and Humsavar for OLFML1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12805648 - 7,488,335(+) CATCG(A/T)ATCAG reference, missense
rs12803046 - 7,509,754(+) GCCGA(A/G)CATTG reference, missense
rs7943470 -- 7,505,878(+) ACTTA(C/T)CTTGA intron-variant
rs7943650 -- 7,491,585(+) TTCCC(A/G)TTAGG intron-variant
rs7944843 -- 7,486,555(+) TAGAA(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML1 Gene

Variant ID Type Subtype PubMed ID
dgv576e59 CNV tandem duplication 20981092
esv3360494 CNV duplication 20981092
nsv1129510 CNV tandem duplication 24896259
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OLFML1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OLFML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML1 Gene

Disorders for OLFML1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OLFML1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrial disease
  • endometrial disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OLFML1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OLFML1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLFML1 Gene

Publications for OLFML1 Gene

  1. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PMID: 18708057) Wan B. … Han Z.G. (FEBS Lett. 2008) 3 4 22 65
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for OLFML1 Gene

Sources for OLFML1 Gene

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