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Aliases for OLFML1 Gene

Aliases for OLFML1 Gene

  • Olfactomedin-Like 1 2 3
  • Olfactomedin-Like Protein 1 3
  • MVAL564 3
  • UNQ564 3

External Ids for OLFML1 Gene

Previous GeneCards Identifiers for OLFML1 Gene

  • GC11P007472
  • GC11P007165

Summaries for OLFML1 Gene

GeneCards Summary for OLFML1 Gene

OLFML1 (Olfactomedin-Like 1) is a Protein Coding gene. An important paralog of this gene is GLDN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML1 Gene

Genomics for OLFML1 Gene

Regulatory Elements for OLFML1 Gene

Genomic Location for OLFML1 Gene

Start:
7,485,369 bp from pter
End:
7,511,897 bp from pter
Size:
26,529 bases
Orientation:
Plus strand

Genomic View for OLFML1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OLFML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML1 Gene

Proteins for OLFML1 Gene

  • Protein details for OLFML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWY5-OLFL1_HUMAN
    Recommended name:
    Olfactomedin-like protein 1
    Protein Accession:
    Q6UWY5
    Secondary Accessions:
    • B4DP03
    • Q569G4

    Protein attributes for OLFML1 Gene

    Size:
    402 amino acids
    Molecular mass:
    45951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OLFML1 Gene

Proteomics data for OLFML1 Gene at MOPED

Post-translational modifications for OLFML1 Gene

Other Protein References for OLFML1 Gene

No data available for DME Specific Peptides for OLFML1 Gene

Domains for OLFML1 Gene

Protein Domains for OLFML1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWY5

UniProtKB/Swiss-Prot:

OLFL1_HUMAN :
  • Q6UWY5
Domain:
  • Contains 1 olfactomedin-like domain.
genes like me logo Genes that share domains with OLFML1: view

No data available for Gene Families for OLFML1 Gene

Function for OLFML1 Gene

Gene Ontology (GO) - Molecular Function for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OLFML1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OLFML1 Gene

Localization for OLFML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OLFML1 Gene COMPARTMENTS Subcellular localization image for OLFML1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OLFML1: view

Pathways for OLFML1 Gene

SuperPathways for OLFML1 Gene

No Data Available

Interacting Proteins for OLFML1 Gene

Gene Ontology (GO) - Biological Process for OLFML1 Gene

None

No data available for Pathways by source for OLFML1 Gene

Transcripts for OLFML1 Gene

Unigene Clusters for OLFML1 Gene

Olfactomedin-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OLFML1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2:

Relevant External Links for OLFML1 Gene

GeneLoc Exon Structure for
OLFML1
ECgene alternative splicing isoforms for
OLFML1

Expression for OLFML1 Gene

mRNA expression in normal human tissues for OLFML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OLFML1 Gene

SOURCE GeneReport for Unigene cluster for OLFML1 Gene Hs.503500

mRNA Expression by UniProt/SwissProt for OLFML1 Gene

Q6UWY5-OLFL1_HUMAN
Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart.
genes like me logo Genes that share expressions with OLFML1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OLFML1 Gene

Orthologs for OLFML1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML1 35
  • 99.25 (n)
  • 99.25 (a)
OLFML1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OLFML1 35
  • 84.33 (n)
  • 84.33 (a)
OLFML1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML1 35
  • 88.53 (n)
  • 88.28 (a)
OLFML1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml1 35
  • 84.43 (n)
  • 82.38 (a)
Olfml1 16
Olfml1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olfml1 35
  • 84.16 (n)
  • 83.58 (a)
chicken
(Gallus gallus)
Aves OLFML1 35
  • 60.47 (n)
  • 52.56 (a)
OLFML1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml1 35
  • 53.77 (n)
  • 41.14 (a)
zebrafish
(Danio rerio)
Actinopterygii BX294190.1 36
  • 41 (a)
OneToOne
LOC100003048 35
  • 52.03 (n)
  • 43.9 (a)
Species with no ortholog for OLFML1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML1 Gene

ENSEMBL:
Gene Tree for OLFML1 (if available)
TreeFam:
Gene Tree for OLFML1 (if available)

Paralogs for OLFML1 Gene

Paralogs for OLFML1 Gene

Selected SIMAP similar genes for OLFML1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OLFML1: view

Variants for OLFML1 Gene

Sequence variations from dbSNP and Humsavar for OLFML1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3884596 -- 7,510,944(-) GAATT(A/C)AATGA utr-variant-3-prime
rs3923014 -- 7,499,332(-) TGGGT(C/T)CAGCC intron-variant
rs3923015 -- 7,499,302(-) CAGAG(A/G)CAATG intron-variant
rs3923092 -- 7,483,560(+) GGTGC(A/G)GCAGG upstream-variant-2KB
rs4237754 -- 7,502,714(+) aattc(G/T)cctgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv259496 OTHER Complex 20981092
esv259966 OTHER Complex 20981092

Relevant External Links for OLFML1 Gene

HapMap Linkage Disequilibrium report
OLFML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML1 Gene

Disorders for OLFML1 Gene

No disorders were found for OLFML1 Gene.

No data available for UniProtKB/Swiss-Prot for OLFML1 Gene

Publications for OLFML1 Gene

  1. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PMID: 18708057) Wan B. … Han Z.G. (FEBS Lett. 2008) 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for OLFML1 Gene

Sources for OLFML1 Gene

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